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https://www.readbyqxmd.com/read/29779025/differential-determinants-of-tubular-phosphate-reabsorption-insights-on-renal-excretion-of-phosphates-in-kidney-disease
#1
Nahid Tabibzadeh, Romuald Mentaverri, Maïté Daroux, Rafik Mesbah, Alexia Delpierre, Jean-Gabriel Paul, Valérie Deken, Ziad A Massy, Pierre Bataille
We assessed the tubular reabsorption of phosphate (TRP) and maximal renal threshold for phosphate reabsorption to glomerular filtration rate (TmPi/GFR) and their determinants in 64 stages 2-4 chronic kidney disease (CKD) patients in order to define the early changes in phosphate metabolism in CKD. In multivariable analysis, TmPi/GFR correlates were estimated GFR (eGFR), intact parathyroid hormone (iPTH), and hemoglobin (R2 = 0.417), while TRP correlates were eGFR, iPTH, 24-h phosphaturia, and calcitriol (R2 = 0...
May 18, 2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29767624/the-maternal-brain-in-women-with-a-history-of-early-life-maltreatment-an-imagination-based-fmri-study-of-conflictual-versus-pleasant-interactions-with-children
#2
Corinne Neukel, Katja Bertsch, Anna Fuchs PhD, Anna-Lena Zietlow, Corinna Reck, Eva Moehler, Romuald Brunner, Felix Bermpohl, Sabine C Herpertz
BACKGROUND: Early-life maltreatment has severe consequences for the affected individual, and it has an impact on the next generation. To improve understanding of the intergenerational effects of abuse, we investigated the consequences of early-life maltreatment on maternal sensitivity and associated brain mechanisms during mother-child interactions. METHODS: In total, 47 mothers (22 with a history of physical and/or sexual childhood abuse and 25 without, all without current mental disorders) took part in a standardized real-life interaction with their 7- to 11-year-old child (not abused) and a subsequent functional imaging script-driven imagery task...
May 16, 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29764119/founder-mutations-for-early-onset-melanoma-as-revealed-by-whole-exome-sequencing-suggests-that-this-is-not-associated-with-the-increasing-incidence-of-melanoma-in-poland
#3
Tadeusz Dębniak, Rodney J Scott, Rodney A Lea, Bohdan Górski, Bartłomiej Masojć, Cezary Cybulski, Andrzej Kram, Romuald Maleszka, Tomasz Gromowski, Katarzyna Paszkowska-Szczur, Aniruddh Kashyap, Marcin R Lener, Karolina Malińska, Emilia Rogoża, Dawid Murawa, Helena Rudnicka, Jakub Deptuła, Jan Lubiński
Purpose: Germline mutations within melanoma susceptibility genes are present only in minority of melanoma patients and it is expected that additional genes will be discovered with next generation sequence technology and whole-exome sequencing. Material and Methods: Herein we performed whole-exome sequencing (WES) on a cohort of 96 unrelated Polish patients with melanoma diagnosed under the age of 40 years who all screened negative for the presence of CDKN2A-variants...
May 14, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29762521/structure-of-the-exopolysaccharide-secreted-by-a-marine-strain-vibrio-alginolyticus
#4
Sophie Drouillard, Isabelle Jeacomine, Laurine Buon, Claire Boisset, Anthony Courtois, Bertrand Thollas, Pierre-Yves Morvan, Romuald Vallée, William Helbert
Vibrio alginolyticus (CNCM I-4151) secretes an exopolysaccharide whose carbohydrate backbone is decorated with amino acids, likely conferring its properties that are appreciated in cosmetics. Here, the secreted polysaccharide of another strain of V. alginolyticus (CNCM I-5034) was characterized by chromatography and one- and two-dimensional NMR spectroscopy experiments. The structure was resolved and shows that the carbohydrate backbone is made of four residues: D-galactose (Gal), D-galacturonic acid (GalA) D-N-acetylglucosamine (GlcNAc) and D-glucuronic acid (GlcA), forming a tetrasaccharide repetition unit [→4)-β-d-GlcA-(1→3)-α-d-Gal-(1→3)-α-d-GalA-(1→3)-β-GlcNAc(1→]...
May 15, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29751956/relation-of-postexercise-reduction-of-arterial-blood-pressure-and-erectile-dysfunction-in-patients-with-coronary-heart-disease
#5
Dariusz Kałka, Jana Gebala, Lesław Rusiecki, Ryszard Smoliński, Jakub Dulanowski, Małgorzata Rusiecka, Anna Biełous-Wilk, Witold Pilecki, Krzysztof Womperski, Romuald Zdrojowy
Penile erection is a hemodynamic process consisting of 2 synchronized components in which the first (active) requires proper vascular endothelium functioning, whereas the second one (passive) is based on a veno-occlusive mechanism. Antihypertensive treatment reduces the passive component, often leading to the development of erectile dysfunction (ED), but lifestyle modifications can improve the sexual functioning. The study aimed to evaluate the association between blood pressure (BP) reduction caused by cardiovascular training and the intensity of ED in men with coronary heart disease...
April 18, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29727439/accuracy-of-computed-tomographic-perfusion-in-diagnosis-of-brain-death-a-prospective-cohort-study
#6
Marcin Sawicki, Joanna Sołek-Pastuszka, Katarzyna Chamier-Ciemińska, Anna Walecka, Romuald Bohatyrewicz
BACKGROUND This study was designed to determine diagnostic accuracy of computed tomographic perfusion (CTP) compared to computed tomographic angiography (CTA) for the diagnosis of brain death (BD). MATERIAL AND METHODS Whole-brain CTP was performed in patients diagnosed with BD and in patients with devastating brain injury with preserved brainstem reflexes. CTA was derived from CTP datasets. Cerebral blood flow (CBF) and volume (CBV) were calculated in all brain regions. CTP findings were interpreted as confirming diagnosis of BD (positive) when CBF and CBV in all ROIs were below 10 mL/100 g/min and 1...
May 4, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29720384/plasma-biomarkers-of-inflammation-and-angiogenesis-predict-cerebral-cavernous-malformation-symptomatic-hemorrhage-or-lesional-growth
#7
Romuald Girard, Hussein A Zeineddine, Janne Koskimaki, Maged D Fam, Ying Cao, Changbin Shi, Thomas J Moore, Rhonda Lightle, Agnieszka Stadnik, Kiranj K Chaudager, Sean P Polster, Robert Shenkar, Ryan C Duggan, David Leclerc, Kevin J Whitehead, Dean Li, Issam A Awad
<u>Rationale:</u> The clinical course of cerebral cavernous malformations (CCMs) is highly unpredictable, with few cross-sectional studies correlating pro-inflammatory genotypes and plasma biomarkers with prior disease severity. <u>Objective:</u> We hypothesize that a panel of 24 candidate plasma biomarkers, with a reported role in the physiopathology of CCMs, may predict subsequent clinically relevant disease activity. <u>Methods and Results:</u> Plasma biomarkers were assessed in non-fasting peripheral venous blood collected from consecutive CCM subjects followed for one year after initial sample collection...
May 2, 2018: Circulation Research
https://www.readbyqxmd.com/read/29719007/gear-and-survey-efficiency-of-patent-tongs-for-oyster-populations-on-restoration-reefs
#8
David M Schulte, Romuald N Lipcius, Russell P Burke
Surveys of restored oyster reefs need to produce accurate population estimates to assess the efficacy of restoration. Due to the complex structure of subtidal oyster reefs, one effective and efficient means to sample is by patent tongs, rather than SCUBA, dredges, or bottom cores. Restored reefs vary in relief and oyster density, either of which could affect survey efficiency. This study is the first to evaluate gear (the first full grab) and survey (which includes selecting a specific half portion of the first grab for further processing) efficiencies of hand-operated patent tongs as a function of reef height and oyster density on subtidal restoration reefs...
2018: PloS One
https://www.readbyqxmd.com/read/29716290/boundary-layer-noise-subtraction-in-hydrodynamic-tunnel-using-robust-principal-component-analysis
#9
Sylvain Amailland, Jean-Hugh Thomas, Charles Pézerat, Romuald Boucheron
The acoustic study of propellers in a hydrodynamic tunnel is of paramount importance during the design process, but can involve significant difficulties due to the boundary layer noise (BLN). Indeed, advanced denoising methods are needed to recover the acoustic signal in case of poor signal-to-noise ratio. The technique proposed in this paper is based on the decomposition of the wall-pressure cross-spectral matrix (CSM) by taking advantage of both the low-rank property of the acoustic CSM and the sparse property of the BLN CSM...
April 2018: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/29709541/the-physiological-orienting-response-in-female-adolescents-with-borderline-personality-disorder
#10
Julian Koenig, Romuald Brunner, Peter Parzer, Franz Resch, Michael Kaess
BACKGROUND: The reflexive startle- and orienting-response have been widely studied in psychiatric disorders. Existing evidence in patients with borderline personality disorder (BPD) is mixed, and limited to adults. The present study addressed clinical correlates of the psychophysiological orienting response in adolescents with BPD. METHODS: Female adolescents (13-19 years) with BPD (n = 30), healthy controls (HC; n = 34), and psychiatric clinical controls (CC; n = 53) participated in the trial...
April 27, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29705497/presynaptic-inhibition-mechanisms-may-subserve-the-spinal-excitability-modulation-induced-by-neuromuscular-electrical-stimulation
#11
Sidney Grosprêtre, Nicolas Gueugneau, Alain Martin, Romuald Lepers
This study aimed at deciphering the origins of spinal excitability modulation that follows neuromuscular electrical stimulation (NMES). Ten participants (age: 24.6 ± 4.2 years) performed 2 randomized NMES sessions on plantar flexors with frequencies of stimulations of 20 or 100 Hz (pulse width: 1 ms) at 20% of maximal voluntary contraction (MVC). Before and after each session, the posterior tibial nerve was stimulated to record H-reflex of soleus (SOL), gastrocnemius medialis (GM) and gastrocnemius lateralis (GL)...
April 24, 2018: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/29694446/clinical-biochemical-and-genetic-risk-factors-for-30-day-and-5-year-mortality-in-518-adult-patients-subjected-to-cardiopulmonary-bypass-during-cardiac-surgery-the-inflacor-study
#12
Maciej Michał Kowalik, Romuald Lango, Piotr Siondalski, Magdalena Chmara, Maciej Brzeziński, Krzysztof Lewandowski, Dariusz Jagielak, Andrzej Klapkowski, Jan Rogowski
There is increasing evidence that genetic variability influences patients' early morbidity after cardiac surgery performed using cardiopulmonary bypass (CPB). The use of mortality as an outcome measure in cardiac surgical genetic association studies is rare. We publish the 30-day and 5-year survival analyses with focus on pre-, intra-, postoperative variables, biochemical parameters, and genetic variants in the INFLACOR (INFLAmmation in Cardiac OpeRations) cohort. In a prospectively recruited cohort of 518 adult Polish Caucasians, who underwent cardiac surgery in which CPB was used, the clinical data, biochemical parameters, IL-6, soluble ICAM-1, TNFα, soluble E-selectin, and 10 single nucleotide polymorphisms were evaluated for their association with 30-day and 5-year mortality...
April 25, 2018: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/29660039/trial-readiness-in-cavernous-angiomas-with-symptomatic-hemorrhage-cash
#13
Sean P Polster, Ying Cao, Timothy Carroll, Kelly Flemming, Romuald Girard, Daniel Hanley, Nicholas Hobson, Helen Kim, James Koenig, Janne Koskimäki, Karen Lane, Jennifer J Majersik, Nichol McBee, Leslie Morrison, Robert Shenkar, Agnieszka Stadnik, Richard E Thompson, Joseph Zabramski, Hussein A Zeineddine, Issam A Awad
BACKGROUND: Brain cavernous angiomas with symptomatic hemorrhage (CASH) are uncommon but exact a heavy burden of neurological disability from recurrent bleeding, for which there is no proven therapy. Candidate drugs to stabilize the CASH lesion and prevent rebleeding will ultimately require testing of safety and efficacy in multisite clinical trials. Much progress has been made in understanding the epidemiology of CASH, and novel biomarkers have been linked to the biological mechanisms and clinical activity in lesions...
April 11, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29659846/is-administration-of-dual-antiplatelet-therapy-beneficial-for-patients-following-off-pump-coronary-artery-bypass-grafting
#14
Maciej Peksa, Sleiman Sebastian Aboul-Hassan, Jakub Marczak, Romuald Cichon
A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was whether administration of dual-antiplatelet therapy (DAPT) following off-pump coronary artery bypass grafting (OPCAB) would improve postoperative clinical outcomes or minimize the incidence of postoperative graft failure. In total, 101 papers were found using the reported search, 14 of which represented the best evidence to answer the clinical question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated...
April 5, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29658534/the-influence-of-osteoporotic-bone-structures-of-the-pelvic-hip-complex-on-stress-distribution-under-impact-load
#15
Katarzyna Arkusz, Tomasz Klekiel, Niezgoda Niezgoda, Romuald Będziński
PURPOSE: The aim of this study was to determine the effect of bone mineral density (BMD) on the stress distribution in pelvic-hip complex (PHC) model which included bone structures and soft tissues. Bone mass changes in osteoporosis and osteopenia were considered in this analysis. In addition, the relations between force direction and stress distribution causing PHC fractures were determined. METHODS: This paper presents the development and validation of a detailed 3D finite element model with high anatomical fidelity of the PHC and BMD changes in trabecular and cortical bones, modelled based on CT scans...
2018: Acta of Bioengineering and Biomechanics
https://www.readbyqxmd.com/read/29658528/gait-changes-in-patients-after-reconstruction-of-facial-bones-with-fibula-and-iliac-crest-free-vascularized-flaps
#16
Małgorzata Syczewska, Romuald Krajewski, Monika Kirwil, Ewa Szczerbik, Małgorzata Kalinowska
PURPOSE: Patients with malignant tumours of the oral cavity require its surgical removal and reconstruction of the bone and soft tissues. The grafts are obtained either from leg (fibula) or pelvis (iliac crest). The removal of grafts from the locomotor apparatus can impair the gait. The aim of this study was to find out how the localization of donor site influences the gait pattern. METHODS: Results obtained for 30 patients were analyzed (16 fibula graft, 14 iliac crest graft)...
2018: Acta of Bioengineering and Biomechanics
https://www.readbyqxmd.com/read/29657310/cardiac-amyloidosis-myocardial-biopsy-as-a-tool-in-chemotherapy-implementation-and-scd-prevention
#17
Małgorzata Cichoń, Katarzyna Mizia-Stec, Romuald Wojnicz, Piotr Kukla, Magdalena Drożdż
No abstract text is available yet for this article.
April 15, 2018: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/29621618/stereoscopic-digital-mammogram-usefulness-in-daily-practice
#18
Romuald Ferre, Pierre-Alain Goumot, Benoît Mesurolle
OBJECTIVES: To assess the benefit of stereoscopic digital mammography in daily practice. METHODS: Stereoscopic digital (SD) mammography allows a fused 3D view of mammogram. A 4-degree cranio-caudal (CC) angle view matched with a regular CC view allows generating a stereoscopic view Three breast radiologists reviewed retrospectively 1,110 stereoscopic digital mammograms (1075 women) performed between November 2011 and February 2013 with the following sequence: each evaluated firstly conventional mammogram alone, and then integrated SD mammograms...
April 2, 2018: Journal of Gynecology Obstetrics and Human Reproduction
https://www.readbyqxmd.com/read/29596519/response-of-human-normal-and-leukemia-cells-to-factors-released-by-amnion-fragments-in-vitro
#19
Zofia Grzywocz, Grazyna Hoser, Stanislawa Sabalinska, Piotr Ladyzynski, Jaroslaw Czubak, Malgorzata Dworczynska, Romuald Debski, Ewa Pius-Sadowska, Boguslaw Machalinski, Jerzy Kawiak
Amnion is a membrane surrounding the embryo/fetus which determine growth factors and interleukins with angiogenic, immunogenic, and anti-inflammatory properties. The aim of the present study was to investigate the effects of conditioned culture medium from 24-h cultures of human amnion (hAM CCM) on migration and proliferation of human umbilical vein endothelial primary cells (HUVECs), freshly isolated bone marrow mononuclear cells (BM MNCs), and Jurkat leukemia cell line. Amnion membrane was freshly isolated from healthy placenta and its fragments cultured in vitro to produce hAM CCM...
2018: PloS One
https://www.readbyqxmd.com/read/29581565/are-mediated-decay-controls-gene-expression-and-cellular-metabolism-upon-oxygen-variations
#20
Bérengère de Toeuf, Romuald Soin, Abdelkarim Nazih, Marija Dragojevic, Dukas Jurėnas, Nadège Delacourt, Long Vo Ngoc, Abel Garcia-Pino, Véronique Kruys, Cyril Gueydan
Hypoxia triggers profound modifications of cellular transcriptional programs. Upon reoxygenation, cells return to a normoxic gene expression pattern and mRNA produced during the hypoxic phase are degraded. TIS11 proteins control deadenylation and decay of transcripts containing AU-rich elements (AREs). We observed that the level of dTIS11 is decreased in hypoxic S2 Drosophila cells and returns to normal level upon reoxygenation. Bioinformatic analyses using the ARE-assessing algorithm AREScore show that the hypoxic S2 transcriptome is enriched in ARE-containing transcripts and that this trend is conserved in human myeloid cells...
March 26, 2018: Scientific Reports
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