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https://www.readbyqxmd.com/read/29129317/the-genetic-legacy-of-the-indian-ocean-slave-trade-recent-admixture-and-post-admixture-selection-in-the-makranis-of-pakistan
#1
Romuald Laso-Jadart, Christine Harmant, Hélène Quach, Nora Zidane, Chris Tyler-Smith, Qasim Mehdi, Qasim Ayub, Lluis Quintana-Murci, Etienne Patin
From the eighth century onward, the Indian Ocean was the scene of extensive trade of sub-Saharan African slaves via sea routes controlled by Muslim Arab and Swahili traders. Several populations in present-day Pakistan and India are thought to be the descendants of such slaves, yet their history of admixture and natural selection remains largely undefined. Here, we studied the genome-wide diversity of the African-descent Makranis, who reside on the Arabian Sea coast of Pakistan, as well that of four neighboring Pakistani populations, to investigate the genetic legacy, population dynamics, and tempo of the Indian Ocean slave trade...
November 1, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29128780/apnea-testing-using-the-oxygen-insufflation-method-for-diagnosis-of-brain-death-may-compromise-pulmonary-function
#2
Joanna Sołek-Pastuszka, Marcin Sawicki, Waldemar Iwańczuk, Klaudyna Kojder, Wojciech Saucha, Zenon Czajkowski, Kornel Chełstowski, Romuald Bohatyrewicz
INTRODUCTION: The aim of our study was to compare the reliability and safety of the classical I-AT with the continuous positive airway pressure apnea test (CPAP-AT). MATERIAL AND METHODS: In the group of 48 patients (group O), an I-AT was performed at the end of BD diagnostic procedures, and approximately 1-1.5h later CPAP-AT with 100% FiO2 and CPAP of 10cm H2O, provided by ventilator in CPAP mode. After pre‑oxygenation with 100% FiO2 for 10min, the PaO2/FiO2 ratio was recorded prior to I-AT at time-point one (T1) and prior to CPAP-AT at time-point two (T2)...
October 28, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/29125616/acute-type-a-aortic-dissection-involving-the-iliac-and-left-renal-arteries-misdiagnosed-as-myocardial-infarction
#3
Paul Nkemtendong Tolefac, Anastase Dzudie, Sidick Mouliom, Leopold Aminde, Romuald Hentchoya, Martin H Abanda, Charles Mve Mvondo, Vanina D Wanko, Henry N Luma
Acute aortic dissection is the most frequent and deadly presentation of acute aortic syndromes. Its incidence is estimated at three to four cases per 100 000 persons per year. Its clinical presentation may be misleading, with misdiagnosis ranging between 14.1 and 38% in many series. A late diagnosis or absence of early and appropriate management is associated with mortality rates as high as 50 and 80% by the third day and second week, respectively, especially in proximal lesions. We report on the case of a 53-year-old man who presented with type A aortic dissection, misdiagnosed as acute myocardial infarction, who later died on day 12 of hospitalisation...
November 3, 2017: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/29104587/notch-and-its-oncogenic-activity-in-human-malignancies
#4
REVIEW
Marlena Brzozowa-Zasada, Adam Piecuch, Marek Michalski, Oliwia Segiet, Józef Kurek, Marzena Harabin-Słowińska, Romuald Wojnicz
Background: Increasing evidence has demonstrated that Notch signaling is deregulated in human hematological malignancies and solid tumors. This signaling has a protumorigenic effect but may also act as a tumor suppressor. How induction of a single pathway gives rise to the opposite effects in different cell types is still unknown. Methods: This review article includes available data from peer-reviewed publications associated with the role of Notch signaling during cancer pathogenesis...
2017: European Surgery: ACA: Acta Chirurgica Austriaca
https://www.readbyqxmd.com/read/29082787/psychopathology-and-borderline-personality-pathology-associated-with-lifetime-self-injurious-behavior-in-adolescent-psychiatric-inpatients-and-detainees
#5
Julian Koenig, Romuald Brunner, Johannes Michael Schmidt, Peter Parzer, Franz Resch, Michael Kaess
OBJECTIVE: Self-injurious behavior (SIB) is a widespread phenomenon among adolescent psychiatric inpatients. It is also reported among delinquent adolescents detained in correctional facilities. While previous studies have addressed different functions of SIB within offender populations, here we investigate particular patterns of borderline personality pathology and psychopathology underlying SIB in both adolescent psychiatric inpatients and detainees. METHOD: Adolescent psychiatric inpatients and detainees were recruited consecutively...
November 2017: Zeitschrift Für Kinder- und Jugendpsychiatrie und Psychotherapie
https://www.readbyqxmd.com/read/29074818/randomized-clinical-trial-of-sevelamer-carbonate-on-serum-klotho-and-fibroblast-growth-factor-23-in-ckd
#6
Sophie Liabeuf, Jean-Philippe Ryckelynck, Najeh El Esper, Pablo Ureña, Christian Combe, Bertrand Dussol, Denis Fouque, Philippe Vanhille, Luc Frimat, Eric Thervet, Romuald Mentaverri, Dominique Prié, Gabriel Choukroun
BACKGROUND AND OBJECTIVES: Epidemiologic studies suggest that higher serum phosphaturic hormone fibroblast growth factor 23 levels are associated with increase morbidity and mortality. The aim of the FGF23 Reduction Efficacy of a New Phosphate Binder in CKD Trial was to evaluate the effect of sevelamer carbonate on serum C-terminal fibroblast growth factor 23 levels in normophosphatemic patients with CKD stage 3b/4. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Patients with CKD, eGFR between 45 and 15 ml/min per 1...
October 26, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29068584/hydronephrosis-in-the-course-of-ureteropelvic-junction-obstruction-an-underestimated-problem-current-opinions-on-the-pathogenesis-diagnosis-and-treatment
#7
REVIEW
Wojciech Krajewski, Joanna Wojciechowska, Janusz Dembowski, Romuald Zdrojowy, Tomasz Szydełko
Ureteropelvic junction obstruction (UPJO) causes a reduction in the urine flow from the renal pelvis into the ureter. Untreated UPJO may cause hydronephrosis, chronic infection or urolithiasis and will often result in progressive deterioration of renal function. Most cases of UPJO are congenital; however, the disease can be clinically silent until adulthood. Other causes, both intrinsic and extrinsic, are acquired and include urolithiasis, post-operative/inflammatory/ischemic stricture, fibroepithelial polyps, adhesions and malignancy...
August 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29059402/efficacy-and-safety-of-nicotinamide-in-haemodialysis-patients-the-nicoren-study
#8
Aurélie Lenglet, Sophie Liabeuf, Najeh El Esper, Sandrine Brisset, Janette Mansour, Anne-Sophie Lemaire-Hurtel, Aurelien Mary, Michel Brazier, Said Kamel, Romuald Mentaverri, Gabriel Choukroun, Albert Fournier, Ziad A Massy
No abstract text is available yet for this article.
September 1, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29057434/early-vesico-amniotic-shunting-does-it-change-the-prognosis-in-fetal-lower-urinary-tract-obstruction-diagnosed-in-the-first-trimester
#9
Marzena Dębska, Piotr Kretowicz, Anna Olędzka, Piotr Gastoł, Joanna Dangel, Małgorzata Świątkowska-Freund, Romuald Dębski
OBJECTIVES: The aim of the study was to assess the outcome of vesico-amniotic shunting performed before 16 weeks of pregnancy in fetuses with severe megacystis diagnosed in the first trimester of pregnancy. MATERIAL AND METHODS: Between January 2008 and October 2012 severe megacystis with the bladder length > 15 mm was diagnosed in 17 fetuses. The procedure of early vesico-amniotic shunting (VAS) was offered to 8 patients with presumably isolated LUTO. The procedure of VAS was performed in 6 fetuses...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/29019483/large-irradiation-doses-can-improve-the-fast-neutron-gamma-discriminating-capability-of-plastic-scintillators
#10
Eva Montbarbon, Marie-Noëlle Amiot, Dominique Tromson, Sylvain Gaillard, Camille Frangville, Romuald Woo, Guillaume H V Bertrand, Robert B Pansu, Jean-Luc Renaud, Matthieu Hamel
When new materials appear as potential alternatives for radiation detection, several criteria have to be fulfilled. The one presented herein is the response variation to large irradiation doses of neutron/gamma discriminating plastic scintillators. Thus, several samples were exposed to high gamma doses reaching 10 kGy. They were characterized in terms of gamma spectrometry and fast neutron/gamma discrimination, prior to and after irradiation. Results show an unexpected increase of the figure of merit (FoM), which is the numerical value for n/γ discrimination performances...
October 25, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28980886/features-from-computerized-texture-analysis-of-breast-cancers-at-pretreatment-mr-imaging-are-associated-with-response-to-neoadjuvant-chemotherapy
#11
Foucauld Chamming's, Yoshiko Ueno, Romuald Ferré, Ellen Kao, Anne-Sophie Jannot, Jaron Chong, Atilla Omeroglu, Benoît Mesurolle, Caroline Reinhold, Benoit Gallix
Purpose To evaluate whether features from texture analysis of breast cancers were associated with pathologic complete response (pCR) after neoadjuvant chemotherapy and to explore the association between texture features and tumor subtypes at pretreatment magnetic resonance (MR) imaging. Materials and Methods Institutional review board approval was obtained. This retrospective study included 85 patients with 85 breast cancers who underwent breast MR imaging before neoadjuvant chemotherapy between April 10, 2008, and March 12, 2015...
October 4, 2017: Radiology
https://www.readbyqxmd.com/read/28973401/three-dimensional-endoscopic-magnification-for-treatment-of-thoracic-spinal-dural-arteriovenous-fistulas-technical-note
#12
Alexander G Weil, Sami Obaid, Chiraz Chaalala, Daniel Shedid, Elsa Magro, Romuald Seizeur, Michel W Bojanowski
BACKGROUND: Treatment of thoracic spinal dural arteriovenous fistulas (DAVFs) by microsurgery has recently been approached using minimally invasive spine surgery (MISS). The advantages of such an approach are offset by difficult maneuverability within the tubular retractor and by the creation of "tunnel vision" with reduced luminosity to a remote surgical target. OBJECTIVE: To demonstrate how the pitfalls of MISS can be addressed by applying 3-D endoscopy to the minimally invasive approach of spinal DAVFs...
July 25, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28970240/thrombospondin1-tsp1-replacement-prevents-cerebral-cavernous-malformations
#13
Miguel Alejandro Lopez-Ramirez, Gregory Fonseca, Hussein A Zeineddine, Romuald Girard, Thomas Moore, Angela Pham, Ying Cao, Robert Shenkar, Bart-Jan de Kreuk, Frederic Lagarrigue, Jack Lawler, Christopher K Glass, Issam A Awad, Mark H Ginsberg
KRIT1 mutations are the most common cause of cerebral cavernous malformation (CCM). Acute Krit1 gene inactivation in mouse brain microvascular endothelial cells (BMECs) changes expression of multiple genes involved in vascular development. These changes include suppression of Thbs1, which encodes thrombospondin1 (TSP1) and has been ascribed to KLF2- and KLF4-mediated repression of Thbs1 In vitro reconstitution of TSP1 with either full-length TSP1 or 3TSR, an anti-angiogenic TSP1 fragment, suppresses heightened vascular endothelial growth factor signaling and preserves BMEC tight junctions...
November 6, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28956284/diagnosing-filamentous-fungal-infections-in-immunocompromised-patients-applying-computed-tomography-guided-percutaneous-lung-biopsies-a-12-year-experience
#14
Cornelia Lass-Flörl, Maria Aigner, David Nachbaur, Stephan Eschertzhuber, Brigitte Bucher, Christian Geltner, Romuald Bellmann, Michaela Lackner, Dorothea Orth-Höller, Reinhard Würzner, Günter Weiss, Bernhard Glodny
BACKGROUND: Invasive fungal diseases (IFD) are an important cause of morbidity and mortality in immunocompromised patients, and early diagnosis and management are a challenge. We evaluated the clinical utility of computed tomography (CT)-guided percutaneous lung biopsies in diagnosing IFD. METHODS: Between 2003 and 2014, we analyzed 2671 CT-guided lung biopsies, from which 157 were IFD associated; we aimed to determine microbiological-based diagnostic accuracy of calcofluor white staining (CFWS), culture, Aspergillus antigen detection (GM), broad-range fungal PCR, and Aspergillus PCR per sample...
September 27, 2017: Infection
https://www.readbyqxmd.com/read/28954498/epidemiology-of-dizziness-in-northern-poland-the-first-polish-neurootologic-survey-of-the-general-population
#15
Romuald Wojtczak, Waldemar Narożny, Jerzy Kuczkowski, Janusz Siebert
INTRODUCTION: Dizziness is a common complaint among patients seen by primary care physicians, neurologist and otolaryngologist. It presents difficult clinical and diagnostic problems. OBJECTIVES: The purpose of this study was to determine the prevalence and incidence of dizziness in the general population of the town and district Bytów, northern Poland, and to describe its clinical characteristics. MATERIAL AND METHODS: Epidemiological questionnaires were completed by 4,799 inhabitants of the town and district of Bytów...
September 21, 2017: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/28940594/characteristics-of-bioelectrical-activity-of-oviducts-and-uterus-during-early-pregnancy-in-sows-recorded-by-telemetry-method
#16
Bartosz Pawlinski, Malgorzata Domino, Romuald Zabielski, Katarzyna Siewruk, Malgorzata Polanska-Plachta, Zdzislaw Gajewski
The aim of the present study was to record the myoelectric activity of the reproduction tract in sows during the estrous phase and the early pregnancy period via telemetry recording system. In a total of eight non-pregnant pigs, the bioelectrical activity was recorded through three silicone electrodes sutured on the oviduct (isthmus and ampulla) and the uterine horn. Blood samples were collected to monitor the levels of progesterone (P4) and luteinizing hormone (LH). The estrous cycle was synchronized with eCG and hCG and the animals were subjected to artificial insemination (AI)...
September 21, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28930640/age-related-decline-in-endurance-running-performance-an-example-of-a-multiple-world-records-holder
#17
Romuald Lepers, Thomas Cattagni
This study examined the age-related decline in endurance running performance of one of the greatest master runners ever, Ed Whitlock. His running performances from 1500 m to marathon were analyzed for five periods of 5 years from 65-69 years to 85-89 years. Despite exceptional running performances for his advanced age, the rate of decline in his performances increased after 80 years and was drastically amplified after 85 years.
September 20, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28929116/the-diagnostic-value-of-nuclear-matrix-proteins-in-bladder-cancer-in-the-aspect-of-environmental-risk-from-carcinogens
#18
Beata Szymańska, Ewa Sawicka, Anna Guzik, Romuald Zdrojowy, Anna Długosz
BACKGROUND: The interaction of environmental factors with genetic susceptibility and detoxification level seems to be an important causative factor in bladder cancer (BC). The aim of this study was to look for a BC marker panel which reflects the environmental risk. The nuclear matrix protein 22 (NMP22), bladder cancer-4 (BLCA-4), and total level proteins NMP22 and BLCA-4 (NMBL) in BC patients with genetic predisposition NAT2 (classified as slow acetylators, SA), DNA damage (8-OHdG), and detoxification by isoenzyme GSTπ activity were measured...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28915604/overexpression-of-a-functional-calcium-sensing-receptor-dramatically-increases-osteolytic-potential-of-mda-mb-231-cells-in-a-mouse-model-of-bone-metastasis-through-epiregulin-mediated-osteoprotegerin-downregulation
#19
Cédric Boudot, Lucie Hénaut, Ursula Thiem, Sandra Geraci, Mariangela Galante, Paulo Saldanha, Zuzana Saidak, Isabelle Six, Philippe Clézardin, Said Kamel, Romuald Mentaverri
INTRODUCTION AND AIMS: Osteolytic bone metastases are observed in advanced cases of breast cancer. In vitro data suggest that the activity of the calcium-sensing receptor (CaSR) expressed by metastatic cells could potentiate their osteolytic potential. This study aimed to demonstrate in vivo the involvement of the CaSR in breast cancer cells osteolytic potential and to identify potential targets linked to CaSR activity. METHODS AND RESULTS: MDA-MB-231 stably transfected with plasmids containing either a full-length wild-type CaSR (CaSR-WT), or a functionally inactive dominant negative mutant (CaSR-DN) or an empty vector (EV) were intratibially injected into Balb/c-Nude mice...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28871391/hemofiltration-induces-generation-of-leukocyte-derived-cd31-cd41-microvesicles-in-sepsis
#20
Georg Franz Lehner, Ulrich Harler, Clemens Feistritzer, Viktoria Maria Haller, Julia Hasslacher, Romuald Bellmann, Michael Joannidis
BACKGROUND: Microvesicles (MV) are extracellular vesicles known to be associated with cellular activation and inflammation. Hemofiltration is an effective blood purification technique for patients with renal failure and possibly also eliminates inflammatory mediators in the setting of sepsis. On the other hand, proinflammatory stimuli are induced by blood contacting the artificial membrane during extracorporeal blood purification. In chronic dialysis patients a systemic increase in MV has been described...
September 4, 2017: Annals of Intensive Care
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