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https://www.readbyqxmd.com/read/28915604/overexpression-of-a-functional-calcium-sensing-receptor-dramatically-increases-osteolytic-potential-of-mda-mb-231-cells-in-a-mouse-model-of-bone-metastasis-through-epiregulin-mediated-osteoprotegerin-downregulation
#1
Cédric Boudot, Lucie Hénaut, Ursula Thiem, Sandra Geraci, Mariangela Galante, Paulo Saldanha, Zuzana Saidak, Isabelle Six, Philippe Clézardin, Said Kamel, Romuald Mentaverri
INTRODUCTION AND AIMS: Osteolytic bone metastases are observed in advanced cases of breast cancer. In vitro data suggest that the activity of the calcium-sensing receptor (CaSR) expressed by metastatic cells could potentiate their osteolytic potential. This study aimed to demonstrate in vivo the involvement of the CaSR in breast cancer cells osteolytic potential and to identify potential targets linked to CaSR activity. METHODS AND RESULTS: MDA-MB-231 stably transfected with plasmids containing either a full-length wild-type CaSR (CaSR-WT), or a functionally inactive dominant negative mutant (CaSR-DN) or an empty vector (EV) were intratibially injected into Balb/c-Nude mice...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28871391/hemofiltration-induces-generation-of-leukocyte-derived-cd31-cd41-microvesicles-in-sepsis
#2
Georg Franz Lehner, Ulrich Harler, Clemens Feistritzer, Viktoria Maria Haller, Julia Hasslacher, Romuald Bellmann, Michael Joannidis
BACKGROUND: Microvesicles (MV) are extracellular vesicles known to be associated with cellular activation and inflammation. Hemofiltration is an effective blood purification technique for patients with renal failure and possibly also eliminates inflammatory mediators in the setting of sepsis. On the other hand, proinflammatory stimuli are induced by blood contacting the artificial membrane during extracorporeal blood purification. In chronic dialysis patients a systemic increase in MV has been described...
September 4, 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28843077/effects-of-maternal-history-of-depression-and-early-life-maltreatment-on-children-s-health-related-quality-of-life
#3
Katja Dittrich, Anna Fuchs, Felix Bermpohl, Justus Meyer, Daniel Führer, Corinna Reichl, Corinna Reck, Dorothea Kluczniok, Michael Kaess, Catherine Hindi Attar, Eva Möhler, Anna-Lena Bierbaum, Anna-Lena Zietlow, Charlotte Jaite, Sibylle Maria Winter, Sabine C Herpertz, Romuald Brunner, Katja Bödeker, Franz Resch
BACKGROUND: There is a well-established link between maternal depression and child mental health. Similar effects have been found for maternal history of early life maltreatment (ELM). However, studies investigating the relationship of children's quality of life and maternal depression are scarce and none have been conducted for the association with maternal ELM. The aim of the present study was to investigate the effects of maternal history of ELM and depression on children's health-related quality of life and to identify mediating factors accounting for these effects...
August 18, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28835335/the-positive-outcome-of-mri-guided-vacuum-assisted-core-needle-breast-biopsies-is-not-influenced-by-a-prior-negative-targeted-second-look-ultrasound
#4
Romuald Ferré, Shaza AlSharif, Ann Aldis, Benoît G Mesurolle
PURPOSE: The study sought to investigate the outcome of breast magnetic resonance-guided biopsies as a function of the indication for magnetic resonance imaging (MRI), the MRI features of the lesions, and the performance or not of a targeted second-look ultrasound (SLUS) prior breast MRI-guided biopsy. METHODS: We identified 158 women with MRI-detected breast lesions scheduled for MRI-guided biopsy (2007-2013). Patient demographics, performance of targeted SLUS, imaging characteristics, and subsequent pathology results were reviewed...
August 21, 2017: Canadian Association of Radiologists Journal, Journal L'Association Canadienne des Radiologistes
https://www.readbyqxmd.com/read/28831062/visualization-of-the-internal-structure-of-didymosphenia-geminata-frustules-using-nano-x-ray-tomography
#5
Izabela Zgłobicka, Qiong Li, Jürgen Gluch, Magdalena Płocińska, Teresa Noga, Romuald Dobosz, Robert Szoszkiewicz, Andrzej Witkowski, Ehrenfried Zschech, Krzysztof J Kurzydłowski
For the first time, the three-dimensional (3D) internal structure of naturally produced Didymosphenia geminata frustules were nondestructively visualized at sub-100 nm resolution. The well-optimized hierarchical structures of these natural organisms provide insight that is needed to design novel, environmentally friendly functional materials. Diatoms, which are widely distributed in freshwater, seawater and wet soils, are well known for their intricate, siliceous cell walls called 'frustules'. Each type of diatom has a specific morphology with various pores, ribs, minute spines, marginal ridges and elevations...
August 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28819935/plasma-biomarkers-of-inflammation-reflect-seizures-and-hemorrhagic-activity-of-cerebral-cavernous-malformations
#6
Romuald Girard, Hussein A Zeineddine, Maged D Fam, Anoop Mayampurath, Ying Cao, Changbin Shi, Robert Shenkar, Sean P Polster, Michael Jesselson, Ryan Duggan, Abdul-Ghani Mikati, Gregory Christoforidis, Jorge Andrade, Kevin J Whitehead, Dean Y Li, Issam A Awad
The clinical course of cerebral cavernous malformations (CCMs) is highly variable. Based on recent discoveries implicating angiogenic and inflammatory mechanisms, we hypothesized that serum biomarkers might reflect chronic or acute disease activity. This single-site prospective observational cohort study included 85 CCM patients, in whom 24 a priori chosen plasma biomarkers were quantified and analyzed in relation to established clinical and imaging parameters of disease categorization and severity. We subsequently validated the positive correlations in longitudinal follow-up of 49 subjects...
August 17, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/28810818/-nonsuicidal-self-injury-in-adolescence-a-clinical-guideline-for-diagnostics-and-therapy
#7
Paul L Plener, Jörg M Fegert, Michael Kaess, Nestor D Kapusta, Romuald Brunner, Rebecca C Groschwitz, Tina In-Albon, Franz Resch, Katja Becker
Objective: Nonsuicidal self-injury (NSSI) is a frequent, clinically relevant phenomenon occurring in adolescence, which can be observed parallel to various mental disorders. Within Europe, Germany has one of the highest prevalence rates in youths, with the lifetime prevalence ranging between 25–35 %. To date a guideline on the treatment of self-injury and stereotypic motoric disorders has been available, the last having been updated in 2006 and expired in 2011. Methods: The guideline development group consisted of members of 11 medical, psychological, or psychotherapeutic professional associations and two members from patient and prevention groups...
September 26, 2016: Zeitschrift Für Kinder- und Jugendpsychiatrie und Psychotherapie
https://www.readbyqxmd.com/read/28806742/dissociating-maternal-responses-to-sad-and-happy-facial-expressions-of-their-own-child-an-fmri-study
#8
Dorothea Kluczniok, Catherine Hindi Attar, Jenny Stein, Sina Poppinga, Thomas Fydrich, Charlotte Jaite, Viola Kappel, Romuald Brunner, Sabine C Herpertz, Katja Boedeker, Felix Bermpohl
BACKGROUND: Maternal sensitive behavior depends on recognizing one's own child's affective states. The present study investigated distinct and overlapping neural responses of mothers to sad and happy facial expressions of their own child (in comparison to facial expressions of an unfamiliar child). METHODS: We used functional MRI to measure dissociable and overlapping activation patterns in 27 healthy mothers in response to happy, neutral and sad facial expressions of their own school-aged child and a gender- and age-matched unfamiliar child...
2017: PloS One
https://www.readbyqxmd.com/read/28791783/quantitative-susceptibility-mapping-as-a-monitoring-biomarker-in-cerebral-cavernous-malformations-with-recent-hemorrhage
#9
Hussein A Zeineddine, Romuald Girard, Ying Cao, Nicholas Hobson, Maged D Fam, Agnieszka Stadnik, Huan Tan, Jingjing Shen, Kiranj Chaudagar, Robert Shenkar, Richard E Thompson, Nichol McBee, Daniel Hanley, Timothy Carroll, Gregory A Christoforidis, Issam A Awad
BACKGROUND: Quantitative Susceptibility Mapping (QSM) MRI allows accurate assessment of iron content in cerebral cavernous malformations (CCM), and a threshold increase by 6% in QSM has been shown to reflect new symptomatic hemorrhage (SH) in previously stable lesions. PURPOSE/HYPOTHESIS: It is unclear how lesional QSM evolves in CCMs after recent SH, and whether this could serve as a monitoring biomarker in clinical trials aimed at preventing rebleeding in these lesions...
August 9, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28773897/extensive-characterization-of-oxide-coated-colloidal-gold-nanoparticles-synthesized-by-laser-ablation-in-liquid
#10
Romuald Intartaglia, Marina Rodio, Mohamed Abdellatif, Mirko Prato, Marco Salerno
Colloidal gold nanoparticles are a widespread nanomaterial with many potential applications, but their aggregation in suspension is a critical issue which is usually prevented by organic surfactants. This solution has some drawbacks, such as material contamination and modifications of its functional properties. The gold nanoparticles presented in this work have been synthesized by ultra-fast laser ablation in liquid, which addresses the above issues by overcoating the metal nanoparticles with an oxide layer...
September 14, 2016: Materials
https://www.readbyqxmd.com/read/28757676/structure-and-function-of-enterocyte-in-intrauterine-growth-retarded-pig-neonates
#11
Karolina Ferenc, Tomasz Pilżys, Tomasz Skrzypek, Damian Garbicz, Michał Marcinkowski, Małgorzata Dylewska, Paweł Gładysz, Oleksandr Skorobogatov, Zdzisław Gajewski, Elżbieta Grzesiuk, Romuald Zabielski
The intestine of intrauterine growth retarded (IUGR) neonates showed different morphology compared to neonates born with normal body weight (NBW). The aim of the present study was to investigate the ultrastructure and proteomic profile of the gut epithelium in IUGR pig neonates with special attention to the digestive and absorptive function. Intestine tissue samples were investigated in 7-day-old IUGR and NBW littermate piglets using histometry, immunofluorescence, scanning electron microscopy (SEM), and mass spectrometry analysis...
2017: Disease Markers
https://www.readbyqxmd.com/read/28756988/tissue-hemostasis-is-shifted-toward-thrombogenesis-in-the-psoriatic-plaques
#12
Edyta Gębska, Agnieszka Sikora-Żydek, Marek Michalski, Edyta Reichman-Warmusz, Józef Kurek, Damian Dudek, Wiktor Skowron, Jerzy Jarząb, Romuald Wojnicz
BACKGROUND: Psoriasis is a common autoimmune disease of unknown etiology. Recently, much attention has been paid to evidence that a local hypercoagulable state is an important contributing factor to the development of inflammatory skin diseases. Thus, the aim of this study was to characterize the local hemostasis in the affected skin of patients with psoriasis. METHODS: Skin biopsies of psoriatic plaques were obtained from 73 consecutive patients (48M, 25F, average age 45 years) with at least a one year history of the disease...
July 15, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28749943/integrated-time-lapse-and-single-cell-transcription-studies-highlight-the-variable-and-dynamic-nature-of-human-hematopoietic-cell-fate-commitment
#13
COMPARATIVE STUDY
Alice Moussy, Jérémie Cosette, Romuald Parmentier, Cindy da Silva, Guillaume Corre, Angélique Richard, Olivier Gandrillon, Daniel Stockholm, András Páldi
Individual cells take lineage commitment decisions in a way that is not necessarily uniform. We address this issue by characterising transcriptional changes in cord blood-derived CD34+ cells at the single-cell level and integrating data with cell division history and morphological changes determined by time-lapse microscopy. We show that major transcriptional changes leading to a multilineage-primed gene expression state occur very rapidly during the first cell cycle. One of the 2 stable lineage-primed patterns emerges gradually in each cell with variable timing...
July 2017: PLoS Biology
https://www.readbyqxmd.com/read/28740277/the-influence-of-ultrasonic-treatment-on-the-growth-of-the-strains-of-salmonella-enterica-subs-typhimurium
#14
Jolanta Joanna Sienkiewicz, Andrzej Wesołowski, Wanda Stankiewicz, Romuald Kotowski
This study proposes the destruction of pathogenic bacteria with the use of ultrasound waves because the more commonly used thermal processing methods often result in lowering the nutritional value of food. The study presents the impact of ultrasound of 20, 40 and 100 kHz frequencies and the power of 10.5 W/cm(2) on the growth of the strain of Salmonella enterica subs. typhimurium. The tests were carried out both in chilled and non-chilled treatment mediums, with an average bacterial population >10(5) and >10(8) CFU/cm(3)...
July 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28714746/age-related-changes-in-endurance-performance-vary-between-modes-of-locomotion-in-men-an-analysis-of-master-world-records
#15
Romuald Lepers, Paul J Stapley, Thomas Cattagni
BACKGROUND: Age-related declines in sport performance are characteristic of all endurance and sprinting disciplines. However, it is not known if the mode of locomotion (i.e. swimming, cycling or running) influences the age-related decline in sport performance in sprinting and endurance events. METHODS: To examine the age-related decline in three different modes of locomotion (i.e. swimming, cycling and running) for endurance and sprint events, the world best performances achieved for males in the age-groups 18-39 years, 40-44 years, 45-49 years, 50-54 years, 55-59 years, 60-64 years, 65-69 years, 70-74 years, 75-79 years and 80-84 years, were compared in swimming (1500-m and 50-m), cycling (1-h and 200-m) and running (10-km and 100-m)...
July 17, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28702763/pharmacokinetics-of-antifungal-drugs-practical-implications-for-optimized-treatment-of-patients
#16
REVIEW
Romuald Bellmann, Piotr Smuszkiewicz
INTRODUCTION: Because of the high mortality of invasive fungal infections (IFIs), appropriate exposure to antifungals appears to be crucial for therapeutic efficacy and safety. MATERIALS AND METHODS: This review summarises published pharmacokinetic data on systemically administered antifungals focusing on co-morbidities, target-site penetration, and combination antifungal therapy. CONCLUSIONS AND DISCUSSION: Amphotericin B is eliminated unchanged via urine and faeces...
July 12, 2017: Infection
https://www.readbyqxmd.com/read/28691430/the-mechanical-properties-of-human-dentin-for-3-d-finite-element-modeling-numerical-and-analytical-evaluation
#17
Wojciech Grzebieluch, Będziński Romuald, Czapliński Tomasz, Urszula Kaczmarek
BACKGROUND: The FEM is often used in investigations of dentin loading conditions; however, its anisotropy is mostly neglected. OBJECTIVES: The purpose of the study was to evaluate the anisotropy and the elastic properties of an equivalent homogenous material model of human dentin as well as to compare isotropic and anisotropic dentin FE-models. MATERIAL AND METHODS: Analytical and numerical dentin homogenization according Luciano and Barbero was performed and E-modulus (E), Poisson's ratios (v) G-modulus (G) were calculated...
June 27, 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28690735/-malaria-serology-test-what-contribution-does-it-make-in-an-endemic-country-such-as-ivory-coast
#18
Amah Patricia Victorine Goran-Kouacou, Gonat Serge Dou, Kalou Dibert Zika, Adjoumanvoulé Honoré Adou, Oppong Richard Yéboah, Rita Ahou Aka, Sansan Hien, Kouabla Liliane Siransy, Koffi N'Guessan, Tariam Agnès Djibangar, Séry Romuald Dassé, Koffi Daho Adoubryn
INTRODUCTION: Malaria serology test seems to have attracted very little interest in endemic countries such as Ivory Coast. However, this examination has been regularly performed in the parasitology laboratory at the Training and Research Unit of Medical Sciences in Abidjan. Our study aimed to highlight the contribution of malaria serology test in our endemic country context. METHODS: We conducted a retrospective study of malaria serology test using Falciparum-Spot IF (bioMerieux) kit for the detection of IgG antiplasmodial antibodies...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28680031/suspicion-of-myocarditis-in-a-patient-with-mitral-valve-prolapse
#19
Mateusz Polak, Romuald Wojnicz, Jarosław Myszor, Jan Szczogiel, Katarzyna Mizia-Stec
No abstract text is available yet for this article.
June 30, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/28675931/new-insights-on-gas-hydroquinone-clathrates-using-in-situ-raman-spectroscopy-formation-dissociation-mechanisms-kinetics-and-capture-selectivity
#20
Romuald Coupan, Eve Péré, Christophe Dicharry, Jean-Philippe Torré
Hydroquinone (HQ) is known to form organic clathrates with different gaseous species over a wide range of pressures and temperatures. However, the enclathration reaction involving HQ is not fully understood. This work offers new elements of understanding HQ clathrate formation and dissociation mechanisms. The kinetics and selectivity of the enclathration reaction were also investigated. The focus was placed on HQ clathrates formed with CO2 and CH4 as guest molecules for potential use in practical applications for the separation of a CO2/CH4 gas mixture...
July 27, 2017: Journal of Physical Chemistry. A
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