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Vesicoureteric reflux

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https://www.readbyqxmd.com/read/28224096/off-label-use-of-sulfur-hexafluoride-in-voiding-urosonography-for-diagnosis-of-vesicoureteral-reflux-in-children-a-survey-on-adverse-events
#1
Alexander Sauer, Clemens Wirth, Isabel Platzer, Henning Neubauer, Simon Veldhoen, Alexander Dierks, Reinhard Kaiser, Andreas Kunz, Meinrad Beer, Thorsten Bley
AIM: To evaluate the risk profile of sulfur hexafluoride in voiding urosonography (VUS) based on a large cohort of children. METHODS: Since 2011 sulfur hexafluoride (SH, SonoVue(®), Bracco, Italy) is the only ultrasound contrast available in the European Union and its use in children has not been approved. Within a 4-year-period, 531 children with suspected or proven vesicoureteral reflux (f/m = 478/53; mean age 4.9 years; 1 mo-25.2 years) following parental informed consent underwent VUS with administration of 2...
February 8, 2017: World Journal of Clinical Pediatrics
https://www.readbyqxmd.com/read/28215835/the-swedish-infant-high-grade-reflux-trial-uti-and-renal-damage
#2
Josefin Nordenström, Sofia Sjöström, Ulla Sillén, Rune Sixt, Per Brandström
INTRODUCTION: High-grade vesicoureteral reflux (VUR) in children is associated with recurrent urinary tract infection (UTI) and renal damage. Breakthrough UTI despite continuous antibiotic prophylaxis (CAP) during the first years of life is a matter of concern and evokes early intervention. We investigated whether early endoscopic treatment (ET) of VUR grade 4-5 can reduce the risk of UTI recurrence and renal scarring. MATERIALS AND METHODS: This prospective, randomized, controlled, multicentre, 1-year follow-up trial comprised 77 infants, <8 months of age with VUR grade 4-5 (Table) randomized to CAP (n = 39) or ET (with prophylaxis until resolution) (n = 38)...
February 2, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28215830/initial-urological-evaluation-and-management-of-children-with-neurogenic-bladder-due-to-myelomeningocele
#3
Cristian Sager, Carol Burek, Juan Pablo Corbetta, Santiago Weller, Javier Ruiz, Ramiro Perea, Enrique Lago, Yesica Gomez, Victor Durán, Juan Carlos López
INTRODUCTION: The proactive management of children with myelomeningocele (MMC) has contributed to decreasing their progression to end-stage renal disease, thanks to early urological evaluation and timing implementation of treatments. OBJECTIVE: To demonstrate that early urological evaluation of the urinary tract in MMC shows functional alterations in most cases, and that it requires medical intervention, even when in some cases the complementary imaging studies do not show any abnormalities...
January 30, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28195356/efficacy-of-onabotulinum-toxin-a-injection-in-pediatric-patients-with-non-neurogenic-detrusor-overactivity
#4
Omer Bayrak, Erkan Sadioglu, Haluk Sen, Kazim Dogan, Sakip Erturhan, Ilker Seckiner
AIMS: To evaluate the effectiveness and reliability of onabotulinum toxin A (onaBoNT-A) injections in pediatric patients with non-neurogenic detrusor overactivity (NNDO). METHODS: Between January 2010 and February 2016, 39 patients underwent onaBoNT-A injections for NNDO, and were evaluated retrospectively. Three-day voiding diary was filled at baseline, and at the postoperative 9th month. The voiding frequency, incontinence episodes, and the cystometric capacity were noted...
February 14, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28191787/urinary-excretion-of-egf-and-mcp-1-in-children-with-vesicoureteral-reflux
#5
Valentina Pastore, Fabio Bartoli
PURPOSE: The aim of this study was to investigate the urinary concentration of epidermal growth factor (EGF) and monocyte chemotactic protein-1 (MCP-1) as reflux nephropathy (RN) biomarkers before and after endoscopic treatment of moderate to severe vesico-ureteral reflux (VUR). MATERIALS AND METHODS: A prospective study was carried out on 72 children with moderate to severe VUR. All patients underwent endoscopic treatment using Macroplastique ® or Deflux®. Vesico-ureteral reflux resolution was tested by post-operative voiding cystourethrography after 3 months and 2 years...
February 10, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28169298/the-value-of-delta-neutrophil-index-in-young-infants-with-febrile-urinary-tract-infection
#6
Jung Won Lee, Seong Heon Kim, Se Jin Park, Keum Hwa Lee, Jae Hyon Park, Andreas Kronbichler, Michael Eisenhut, Ji Hong Kim, Jong Wook Lee, Jae Il Shin
Delta neutrophil index (DNI) is the fraction of circulating immature granulocytes, which reflects severe bacterial infections and septic condition but has not been studied in urinary tract infection (UTI). Here, we evaluated the value of DNI in predicting acute pyelonephritis (APN) or vesicoureteral reflux (VUR) using the data of 288 patients. Conventional inflammatory markers (white blood cell [WBC] count, erythrocyte sedimentation rate [ESR], C-reactive protein [CRP]), and DNI were measured. WBC, CRP, ESR and DNI were higher in APN than in lower UTI (p < 0...
February 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28164035/proximal-ureteral-atresia-a-rare-congenital-anomaly-incidental-finding-a-case-report
#7
Cosimo Bleve, Maria Luisa Conighi, Lorella Fasoli, Valeria Bucci, Francesco Battaglino, Salvatore Fabio Chiarenza
Ureteral atresia is a rare disease usually associated with a non-functioning dysplastic kidney. The condition may be unilateral or bilateral; focal, short or long and may involve any part of the ureter. Association with other urinary anomalies is rare. We report the case of a 10-month-old boy with prenatal diagnosis of multicystic right kidney. This suspicion was confirmed after birth by ultrasound and static scintigraphy; a right vesicoureteral reflux (VUR) was recorded at cystography. The boy presented a regular renal function but was hospitalized twice for suspected pyelonephritis between the 8th and the 10th month of life and were recorded occasional mild changes in blood pressure...
January 2017: Translational pediatrics
https://www.readbyqxmd.com/read/28161229/-secondary-megaureter-a-rare-complication-of-deflux-%C3%A2-endoscopic-management-of-vesicoureteral-reflux-in-children
#8
N Boudaoud, A Line, M Pons, F Lefebvre, M A Bouche Pillon, C Francois, M L Poli Merol
Endoscopic management is the gold standard for symptomatic low-grade vesicoureteral reflux (VUR) in children. Deflux(®) (hyaluronic acid/dextranomer) injection is highly effective and has very few complications. We report on two cases of secondary megaureter after Deflux(®) injections. In the first case, a boy presented with Grade 4 VUR. He received a bilateral Deflux(®) injection with a total of three syringes. The postoperative ultrasound was normal. However, a check-up ultrasound 3 years later showed a significant ureteropyelocalyceal dilatation, with stasis and decreased renal function on scintigraphy, the reason why antireflux surgery (Cohen procedure) was performed...
February 1, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28154883/-urinary-tract-infections-in-children
#9
E Lellig, M Apfelbeck, J Straub, A Karl, S Tritschler, C G Stief, M Riccabona
Urinary tract infections (UTI) are the most common bacterial infections in children. The symptoms are not very specific and range from abdominal pain, poor feeding to nocturnal urinary incontinence. The technique of collecting urine plays an important role for securing the diagnosis. The best way to obtain urine in non-toilet-trained children is catheterization or suprapubic bladder aspiration. In toilet-trained children midstream urine is an acceptable alternative after cleaning the foreskin or labia. In the case of an infection a prompt empirical antibiotic therapy is necessary to reduce the risk of parenchymal scarring of the kidneys...
February 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28149748/extravasation-of-urine-associated-with-bilateral-complete-ureteral-duplication-vesicoureteral-reflux-and-benign-prostatic-hyperplasia
#10
Issei Suzuki, Kanya Kaga, Kohei Takei, Yuumi Tokura, Kazumasa Sakamoto, Daisaku Nishihara, Tomoya Mizuno, Hideo Yuki, Hironori Betsunoh, Hideyuki Abe, Masahiro Yashi, Yoshitatsu Fukabori, Tomonori Yamanishi, Takao Kamai
We report a rare case of extravasation of urine, which may be associated with bilateral complete ureteral duplication, vesicoureteral reflux (VUR), and benign prostatic hyperplasia (BPH). A 71-year-old male presented with a complaint of right abdominal pain. An extravasation of urine was noted, and was improved by indwelling urethral catheterization. Transurethral resection of the prostate and the endoscopic subureteral injection of dextanomer/hyaluronic acid were performed for the treatment of BPH and VUR, respectively...
February 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28138405/comparison-of-voiding-cystourethrography-and-urosonography-with-second-generation-contrast-agents-in-simultaneous-prospective-study
#11
Maciej Piskunowicz, Dominik Świętoń, Dorota Rybczyńska, Piotr Czarniak, Arkadiusz Szarmach, Mariusz Kaszubowski, Edyta Szurowska
BACKGROUND: The invasiveness and exposure to radiation in voiding cystourethrography led to the introduction of alternative methods of diagnosis of vesicoureteral reflux, including contrast enhanced voiding urosonography. While there is a limited number of studies comparing these methods using new generation ultrasound contrast agents, none of them compared both methods simultaneously. This study is aimed at assessing agreement between contrast enhanced voiding urosonography with second-generation ultrasound contrast agents and voiding cystourethrography...
December 2016: Journal of Ultrasonography
https://www.readbyqxmd.com/read/28130103/multi-institutional-review-of-outcomes-and-complications-of-robot-assisted-laparoscopic-extravesical-ureteral-reimplantation-for-treatment-of-primary-vesicoureteral-reflux-in-children
#12
William R Boysen, Jonathan S Ellison, Christina Kim, Chester J Koh, Paul Noh, Benjamin Whittam, Blake Palmer, Aseem Shukla, Andrew Kirsch, Mohan S Gundeti
PURPOSE: Robot-assisted laparoscopic extravesical ureteral reimplantation (RALUR-EV) has been proposed as a minimally invasive alternative to open ureteral reimplantation for correcting primary vesicoureteral reflux (VUR) in children. However, in the current literature there are conflicting data regarding the safety and efficacy of this approach. Amidst ongoing debate, we analyzed outcomes and complications from this procedure in a large, multi-institutional cohort. MATERIALS AND METHODS: We reviewed the records of children who underwent RALUR-EV at 9 academic centers from 2005 to 2014...
January 24, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28128899/unilateral-extravesical-ureteral-reimplantation-via-inguinal-incision-for-the-correction-of-vesicoureteral-reflux-a-10-year-experience
#13
Michael Yap, Unwanabong Nseyo, Hena Din, Madhu Alagiri
INTRODUCTION AND OBJECTIVE: Multiple options exist for the surgical management of vesicoureteral reflux (VUR). We report on our 10-year experience using the inguinal approach to extravesical ureteral reimplantation (EVR). MATERIALS AND METHODS: Patient characteristics of age, gender, and reflux grade were obtained and outcomes of operative time, hospital stay, and radiographic resolution were assessed. RESULTS: 71 girls and 20 boys with a mean age of 74 months (range 14-164) underwent inguinal EVR via a 3...
January 27, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28126219/imaging-of-the-pediatric-urinary-system
#14
REVIEW
Ellen M Chung, Karl A Soderlund, Kimberly E Fagen
Recent advances in pediatric urinary tract imaging include development of alternative imaging methods without use of ionizing radiation; evolving understanding of the relationship of urinary tract infection, vesicoureteral reflux, and renal scarring, including the important role of dysfunctional voiding; development of a consensus nomenclature and risk-based classification for fetal and antenatal urinary tract dilation; advances in the understanding of sporadic and inherited renal cystic disease; and a proposed modification of the Bosniak criteria for distinguishing complex renal cysts from cystic renal tumors in children...
March 2017: Radiologic Clinics of North America
https://www.readbyqxmd.com/read/28124539/one-staged-reconstruction-of-bladder-exstrophy-in-male-patients-long-term-follow-up-outcomes
#15
Amilcar Martins Giron, Marcos Figueiredo Mello, Paulo Afonso Carvalho, Paulo Renato Marcelo Moscardi, Roberto Iglesias Lopes, Miguel Srougi
INTRODUCTION: The surgical correction of bladder exstrophy remains challenging. In our institution, the repair has evolved from a staged repair to one-stage reconstruction. The one-stage reconstruction includes; bladder closure, Cantwell-Ransley neourethroplasty and abdominoplasty using groin flaps, without the need of pelvic ostheotomies. Repair of urinary continence (UC) and vesicoureteral reflux (VUR) is done after development of the infant. OBJECTIVE: To present our experience of our modified one-stage reconstruction of bladder exstrophy in male patients...
January 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28121664/radiotracer-injection-into-the-catheter-balloon-a-subtle-pitfall-which-can-be-overlooked-in-direct-radionuclide-cystography
#16
Toktam Massoudi, Hamed Shayegani, Ramin Sadeghi
We reported a 4-year-old girl with history of bilateral vesicoureteral reflux who underwent direct radionuclide cystography in our department. Radiotracer was mistakenly injected in the catheter balloon. The filling phase showed no change in the bladder volume, and the catheter balloon was apparent as an intense activity in the base of the bladder. The procedure was repeated with correct injection of the tracer into the catheter. Wrong injection of the radiotracer into the catheter balloon should always be borne in mind in similar cases...
January 24, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28119847/ureteral-rupture-caused-by-a-suprapubic-catheter-in-a-male-patient-with-spinal-cord-injury-a-case-report
#17
Hye Jung Choi, Chang Han Lee, Heesuk Shin
Spinal cord injury (SCI) may lead to urinary system disturbances. Patients with SCI usually have neurogenic bladder, and treatment optionss for this condition include clean intermittent catheterization and a permanent indwelling urethral or suprapubic catheter. Complications of catheterization include urinary tract infection, calculi, urinary tract injury, bladder contraction, bladder spasm, renal dysfunction, bladder cancer, and so forth. To the best of our knowledge, ureteral rupture is an unusual complication of catheterization, and ureteral rupture has been rarely reported in SCI patients...
December 2016: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28111223/parenchyma-to-hydronephrosis-area-ratio-phar-is-a-promising-outcome-measure-to-quantify-upper-tract-changes-in-infants-with-high-grade-prenatal-hydronephrosis
#18
Mandy Rickard, Armando J Lorenzo, Caroline Munoz, Luis H Braga
OBJECTIVE: To explore the value of renal parenchyma-to-hydronephrosis area ratio (PHAR) in detecting trends of hydronephrosis (HN) improvement or worsening and response to surgical intervention. MATERIALS AND METHODS: Initial and follow-up sagittal renal ultrasound images of patients entered into a prenatal HN database from 2008-2016, with baseline SFU grades III and IV HN and without vesicoureteral reflux, were evaluated using NIH-sponsored image-processing software...
January 19, 2017: Urology
https://www.readbyqxmd.com/read/28098106/the-role-of-dynamic-renal-scintigraphy-on-clinical-decision-making-in-hydronephrotic-children
#19
Seçil Arslansoyu Çamlar, Nazlı Deveci, Alper Soylu, Mehmet Atilla Türkmen, Derya Özmen, Gamze Çapakaya, Salih Kavukçu
Hydronephrosis may be related to an obstructive cause, ureteropelvic/uretero-vesical junction obstruction or nonobstructive [vesicoureteral reflux (VUR)]. When an obstructive pathology is considered, dynamic renal scintigraphy may help to predict whether it is a true obstruction or not. In this study, we aimed to determine the contribution of dynamic renal scintigraphy with [99] mTc-MAG-3 to the clinical decision-making for surgery in hydronephrotic children. Files of the patients evaluated by MAG-3 scintigraphy for antenatal (AH)/postnatal (PH) hydronephrosis between 1992 and 2014 were reviewed...
January 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28097262/lessons-learned-over-a-decade-of-pediatric-robotic-ureteral-reimplantation
#20
REVIEW
Minki Baek, Chester J Koh
The da Vinci robotic system has improved surgeon dexterity, ergonomics, and visualization to allow for a minimally invasive option for complex reconstructive procedures in children. Over the past decade, robot-assisted laparoscopic ureteral reimplantation (RALUR) has become a viable minimally invasive surgical option for pediatric vesicoureteral reflux (VUR). However, higher-than-expected complication rates and suboptimal reflux resolution rates at some centers have also been reported. The heterogeneity of surgical outcomes may arise from the inherent and underestimated complexity of the RALUR procedure that may justify its reclassification as a complex reconstructive procedure and especially for robotic surgeons early in their learning curve...
January 2017: Investigative and Clinical Urology
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