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https://www.readbyqxmd.com/read/29351356/epha2-ephrin-a1-mediate-corneal-epithelial-cell-compartmentalization-via-adam10-regulation-of-egfr-signaling
#1
Nihal Kaplan, Rosa Ventrella, Han Peng, Sonali Pal-Ghosh, Constadina Arvanitis, Joshua Z Rappoport, Brian J Mitchell, Mary Ann Stepp, Robert M Lavker, Spiro Getsios
Purpose: Progenitor cells of the limbal epithelium reside in a discrete area peripheral to the more differentiated corneal epithelium and maintain tissue homeostasis. What regulates the limbal-corneal epithelial boundary is a major unanswered question. Ephrin-A1 ligand is enriched in the limbal epithelium, whereas EphA2 receptor is concentrated in the corneal epithelium. This reciprocal pattern led us to assess the role of ephrin-A1 and EphA2 in limbal-corneal epithelial boundary organization...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29349208/in-sickness-and-in-health-the-role-of-marital-partners-in-cancer-survival
#2
Astri Syse, Torkild Hovde Lyngstad
Married cancer patients enjoy a survival advantage, potentially attributable to better health at diagnosis, earlier contact with health personnel, and/or access to resources to ensure more optimal treatment. These mechanisms only invoke the mere presence of a partner, but partners bring varying amounts of resources into the household. It is likely that also spousal resources contribute to differentials in survival net of own resources, as gradients in survival by the latter are well documented. Our aim is to examine the combined roles of own and spouses' socioeconomic characteristics (SES) and age for cancer survival...
December 2017: SSM—Population Health
https://www.readbyqxmd.com/read/29347287/solution-of-the-riemann-problem-for-polarization-waves-in-a-two-component-bose-einstein-condensate
#3
S K Ivanov, A M Kamchatnov, T Congy, N Pavloff
We provide a classification of the possible flows of two-component Bose-Einstein condensates evolving from initially discontinuous profiles. We consider the situation where the dynamics can be reduced to the consideration of a single polarization mode (also denoted as "magnetic excitation") obeying a system of equations equivalent to the Landau-Lifshitz equation for an easy-plane ferromagnet. We present the full set of one-phase periodic solutions. The corresponding Whitham modulation equations are obtained together with formulas connecting their solutions with the Riemann invariants of the modulation equations...
December 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347014/imperfections-impacts-and-the-singularity-of-euler-s-disk
#4
Tamás Baranyai, Péter L Várkonyi
The motion of a rigid, spinning disk on a flat surface ends with a dissipation-induced finite-time singularity. The problem of finding the dominant energy absorption mechanism during the last phase of the motion generated a lively debate during the past two decades. Various candidates including air drag and different types of friction have been considered, nevertheless impacts have not been examined until now. We investigate the effect of impacts caused by geometric imperfections of the disk and of the underlying flat surface, through analyzing the dynamics of polygonal disks with unilateral point contacts...
September 2017: Physical Review. E
https://www.readbyqxmd.com/read/29345953/micro-to-nanoscale-engineering-of-surface-precipitates-using-reconfigurable-contact-lines
#5
Prasenjit Kabi, Swetaprovo Chaudhuri, Saptarshi Basu
Nanoscale engineering has traditionally adopted the chemical route of synthesis or opto-chemical techniques like lithography requiring large process times, expensive equipment and an inert environment. Directed self-assembly using evaporation of nanocolloidal droplet can be a potential low-cost alternative across various industries ranging from semiconductors to biomedical systems. It is relatively simple to scale and re-orient the evaporation driven internal flow field in an evaporating droplet which can direct dispersed matter into functional agglomerates...
January 18, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29344865/isolation-of-distinct-types-of-neurons-from-fresh-brain-tissue-using-laser-microdissection-in-combination-with-high-performance-liquid-chromatography-mass-spectrometry
#6
Luisa Aring, Simone Steinbach, Katrin Marcus, Caroline May
Humans age and the ageing process affects cells in all areas of the human body, including nerve cells within the brain. With advancing age there is also a rise in the probability of developing a neurodegenerative disorder such as, e.g., amyotrophic lateral sclerosis, Huntington's disease, Parkinson's disease, or Alzheimer's disease. In all these age-related neurodegenerative disorders, distinct neuron populations within specific brain regions are primarily affected. For example, Parkinson's disease is characterized by a slowly progressive degeneration of dopaminergic neurons in the substantia nigra whereas the entorhinal cortex is first affected in Alzheimer's disease...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29343645/crystal-structure-of-the-mammalian-lipopolysaccharide-detoxifier
#7
Alexei Gorelik, Katalin Illes, Bhushan Nagar
LPS is a potent bacterial endotoxin that triggers the innate immune system. Proper recognition of LPS by pattern-recognition receptors requires a full complement of typically six acyl chains in the lipid portion. Acyloxyacyl hydrolase (AOAH) is a host enzyme that removes secondary (acyloxyacyl-linked) fatty acids from LPS, rendering it immunologically inert. This activity is critical for recovery from immune tolerance that follows Gram-negative infection. To understand the molecular mechanism of AOAH function, we determined its crystal structure and its complex with LPS...
January 17, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29343184/foot-strike-pattern-in-preschool-children-during-running-sex-and-shod-unshod-differences
#8
Pedro Á Latorre-Román, Juan A Párraga-Montilla, Ignacio Guardia-Monteagudo, Felipe García-Pinillos
PURPOSE: This study aims to determine the foot strike patterns (FSPs) and neutral support (no inversion [INV]/eversion [EVE] and no foot rotation) in preschool children, as well as to determine the influence of shod/unshod conditions and sex. METHODS: A total of 1356 children aged 3-6 years (673 boys and 683 girls) participated in this study. A sagittal and frontal-plane video (240 Hz) was recorded using a high-speed camcorder to record the following variables: rearfoot strike (RFS), midfoot strike (MFS), forefoot strike (FFS), inversion/ eversion (INV/EVE) and foot rotation on initial contact...
January 17, 2018: European Journal of Sport Science
https://www.readbyqxmd.com/read/29340752/the-effect-of-indehiscent-point-mutations-on-silique-shatter-resistance-in-oilseed-rape-brassica-napus
#9
Janina Braatz, Hans-Joachim Harloff, Nazgol Emrani, Chirlon Elisha, Lars Heepe, Stanislav N Gorb, Christian Jung
This study elucidates the influence of indehiscent mutations on rapeseed silique shatter resistance. A phenotype with enlarged replum-valve joint area and altered cell dimensions in the dehiscence zone is described. Silique shattering is a major factor reducing the yield stability of oilseed rape (Brassica napus). Attempts to improve shatter resistance often include the use of mutations in target genes identified from Arabidopsis (Arabidopsis thaliana). A variety of phenotyping methods assessing the level of shatter resistance were previously described...
January 16, 2018: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/29337433/numerical-simulation-of-two-consecutive-nasal-respiratory-cycles-toward-a-better-understanding-of-nasal-physiology
#10
Ludovic de Gabory, Nicolas Reville, Yannick Baux, Nicolas Boisson, Laurence Bordenave
BACKGROUND: Computational fluid dynamic (CFD) simulations have greatly improved the understanding of nasal physiology. We postulate that simulating the entire and repeated respiratory nasal cycles, within the whole sinonasal cavities, is mandatory to gather more accurate observations and better understand airflow patterns. METHODS: A 3-dimensional (3D) sinonasal model was constructed from a healthy adult computed tomography (CT) scan which discretized in 6.6 million cells (mean volume, 0...
January 16, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29334150/a-general-method-for-the-chemical-synthesis-of-large-scale-seamless-transition-metal-dichalcogenide-electronics
#11
Li Li, Yichuan Guo, Yuping Sun, Long Yang, Liang Qin, Shouliang Guan, Jinfen Wang, Xiaohui Qiu, Hongbian Li, Yuanyuan Shang, Ying Fang
The capability to directly build atomically thin transition metal dichalcogenide (TMD) devices by chemical synthesis offers important opportunities to achieve large-scale electronics and optoelectronics with seamless interfaces. Here, a general approach for the chemical synthesis of a variety of TMD (e.g., MoS2 , WS2 , and MoSe2 ) device arrays over large areas is reported. During chemical vapor deposition, semiconducting TMD channels and metallic TMD/carbon nanotube (CNT) hybrid electrodes are simultaneously formed on CNT-patterned substrate, and then coalesce into seamless devices...
January 15, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29331799/the-deepwater-horizon-oil-spill-coast-guard-cohort-study-a-cross-sectional-study-of-acute-respiratory-health-symptoms
#12
Melannie Alexander, Lawrence S Engel, Nathan Olaiya, Li Wang, John Barrett, Laura Weems, Erica G Schwartz, Jennifer A Rusiecki
INTRODUCTION: Over 8500 United States Coast Guard (USCG) personnel were deployed in response to the Deepwater Horizon (DWH) oil spill; however, human respiratory effects as a result of spill-related exposures are relatively unknown. METHODS: USCG personnel who responded to the DWH oil spill were queried via survey on exposures to crude oil and oil dispersant, and acute respiratory symptoms experienced during deployment. Adjusted log binomial regressions were used to calculate prevalence ratios (PRs) and 95% confidence intervals (CI), investigating the associations between oil spill exposures and respiratory symptoms...
January 10, 2018: Environmental Research
https://www.readbyqxmd.com/read/29329534/a-large-scale-study-of-a-poultry-trading-network-in-bangladesh-implications-for-control-and-surveillance-of-avian-influenza-viruses
#13
N Moyen, G Ahmed, S Gupta, T Tenzin, R Khan, T Khan, N Debnath, M Yamage, D U Pfeiffer, G Fournie
BACKGROUND: Since its first report in 2007, avian influenza (AI) has been endemic in Bangladesh. While live poultry marketing is widespread throughout the country and known to influence AI dissemination and persistence, trading patterns have not been described. The aim of this study is to assess poultry trading practices and features of the poultry trading networks which could promote AI spread, and their potential implications for disease control and surveillance. Data on poultry trading practices was collected from 849 poultry traders during a cross-sectional survey in 138 live bird markets (LBMs) across 17 different districts of Bangladesh...
January 12, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29324959/surveillance-of-intradomiciliary-contacts-of-leprosy-cases-perspective-of-the-client-in-a-hyperendemic-municipality
#14
Helizandra Simoneti Bianchini Romanholo, Eliana Amorim de Souza, Alberto Novaes Ramos Júnior, Adélia Cileode Gomes Castelo Branco Kaiser, Ismália Oliveira da Silva, Aline Lima Brito, Cídia Vasconcellos
OBJECTIVE: To characterize approach methods for intradomiciliary contacts (IdC) of leprosy cases resident in Northern Brazil, during 2001-2012. METHOD: A cross-sectional and descriptive study in the state of Rondônia. Included IdC of leprosy cases diagnosed/reported in SINAN-Ministry of Health (MS), 2001-2012. A semi-structured instrument was applied to the IdCs, with six interventions: complete dermatological examination; complete neurological examination; BCG vaccination; instructions for return to the health unit; BCG guidance; and guidance to mobilize other contacts...
January 2018: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29324862/taking-two-to-tango-fmri-analysis-of-improvised-joint-action-with-physical-contact
#15
Léa A S Chauvigné, Michel Belyk, Steven Brown
Many forms of joint action involve physical coupling between the participants, such as when moving a sofa together or dancing a tango. We report the results of a novel two-person functional MRI study in which trained couple dancers engaged in bimanual contact with an experimenter standing next to the bore of the magnet, and in which the two alternated between being the leader and the follower of joint improvised movements. Leading showed a general pattern of self-orientation, being associated with brain areas involved in motor planning, navigation, sequencing, action monitoring, and error correction...
2018: PloS One
https://www.readbyqxmd.com/read/29324349/organic-staining-on-bone-from-exposure-to-wood-and-other-plant-materials
#16
Corey R Pollock, James T Pokines, Jonathan D Bethard
Determining the depositional environment and the postmortem alterations to a set of remains are necessary aspects of a forensic investigation to explain the circumstances surrounding the death of an individual. The present study examines organic staining as a method for reconstructing the depositional environment of skeletal remains and the taphonomic agents with which they came into contact. Organic staining results largely from tannins leaching from plant materials and therefore can be seen on bone deposited in wooden coffin environments or on terrestrial surfaces...
December 21, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29323524/work-disability-in-soldiers-with-posttraumatic-stress-disorder-posttraumatic-embitterment-disorder-and-not-event-related-common-mental-disorders
#17
Beate Muschalla, Heinrich Rau, Gerd Dieter Willmund, Christine Knaevelsrud
OBJECTIVE: Posttraumatic mental disorders may occur with different affect qualities. Best known is posttraumatic stress disorder (PTSD), a conditioned anxiety reaction with intrusions. Another event-related mental disorder is posttraumatic embitterment (PTED), characterized by affect of embitterment and thoughts of revenge, occurring after an event deeply hurting basic beliefs. Knowing about associated disability is important for treatment and sociomedical decisions. This is the first study to explore work-disability in patients with PTSD, PTED, and not-event-related common mental disorder (CMD)...
January 2018: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/29321870/contrasting-genetic-metrics-and-patterns-among-naturalized-rainbow-trout-oncorhynchus-mykiss-in-two-patagonian-lakes-differentially-impacted-by-trout-aquaculture
#18
Cristian B Canales-Aguirre, Lisa W Seeb, James E Seeb, María I Cádiz, Selim S Musleh, Ivan Arismendi, Gonzalo Gajardo, Ricardo Galleguillos, Daniel Gomez-Uchida
Different pathways of propagation and dispersal of non-native species into new environments may have contrasting demographic and genetic impacts on established populations. Repeated introductions of rainbow trout (Oncorhynchus mykiss) to Chile in South America, initially through stocking and later through aquaculture escapes, provide a unique setting to contrast these two pathways. Using a panel of single nucleotide polymorphisms, we found contrasting genetic metrics and patterns among naturalized trout in Lake Llanquihue, Chile's largest producer of salmonid smolts for nearly 50 years, and Lake Todos Los Santos (TLS), a reference lake where aquaculture has been prohibited by law...
January 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29321005/the-impact-of-regular-school-closure-on-seasonal-influenza-epidemics-a-data-driven-spatial-transmission-model-for-belgium
#19
Giancarlo De Luca, Kim Van Kerckhove, Pietro Coletti, Chiara Poletto, Nathalie Bossuyt, Niel Hens, Vittoria Colizza
BACKGROUND: School closure is often considered as an option to mitigate influenza epidemics because of its potential to reduce transmission in children and then in the community. The policy is still however highly debated because of controversial evidence. Moreover, the specific mechanisms leading to mitigation are not clearly identified. METHODS: We introduced a stochastic spatial age-specific metapopulation model to assess the role of holiday-associated behavioral changes and how they affect seasonal influenza dynamics...
January 10, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29320556/care-seeking-patterns-among-families-that-experienced-under-five-child-mortality-in-rural-rwanda
#20
Daniel M Kagabo, Catherine M Kirk, Benjamin Bakundukize, Bethany L Hedt-Gauthier, Neil Gupta, Lisa R Hirschhorn, Willy C Ingabire, Dominique Rouleau, Fulgence Nkikabahizi, Catherine Mugeni, Felix Sayinzoga, Cheryl L Amoroso
BACKGROUND: Over half of under-five deaths occur in sub-Saharan Africa and appropriate, timely, quality care is critical for saving children's lives. This study describes the context surrounding children's deaths from the time the illness was first noticed, through the care-seeking patterns leading up to the child's death, and identifies factors associated with care-seeking for these children in rural Rwanda. METHODS: Secondary analysis of a verbal and social autopsy study of caregivers who reported the death of a child between March 2013 to February 2014 that occurred after discharge from the child's birth facility in southern Kayonza and Kirehe districts in Rwanda...
2018: PloS One
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