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https://www.readbyqxmd.com/read/28917444/developing-a-hospital-wide-fertility-preservation-service-for-pediatric-and-young-adult-patients
#1
Claire A Carlson, Thomas F Kolon, Peter Mattei, Wendy Hobbie, Clarisa R Gracia, Sue Ogle, Jill P Ginsberg
PURPOSE: Gonadal damage is a common consequence of treatment for pediatric malignancies. Nononcologic conditions may also utilize treatments with potential impact on fertility. Models for oncology fertility preservation programs have emerged and demonstrate that a multidisciplinary team approach can have a positive impact on referral patterns, appropriate risk counseling, and access to fertility preservation options. Expansion of programmatic breadth is needed, providing improved care to nonmalignant conditions where the disease itself may impact reproductive health or treatment modalities...
September 13, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28916801/taming-active-turbulence-with-patterned-soft-interfaces
#2
P Guillamat, J Ignés-Mullol, F Sagués
Active matter embraces systems that self-organize at different length and time scales, often exhibiting turbulent flows apparently deprived of spatiotemporal coherence. Here, we use a layer of a tubulin-based active gel to demonstrate that the geometry of active flows is determined by a single length scale, which we reveal in the exponential distribution of vortex sizes of active turbulence. Our experiments demonstrate that the same length scale reemerges as a cutoff for a scale-free power law distribution of swirling laminar flows when the material evolves in contact with a lattice of circular domains...
September 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/28916711/comparative-analysis-of-three-dimensional-chromosomal-architecture-identifies-a-novel-fetal-hemoglobin-regulatory-element
#3
Peng Huang, Cheryl A Keller, Belinda Giardine, Jeremy D Grevet, James O J Davies, Jim R Hughes, Ryo Kurita, Yukio Nakamura, Ross C Hardison, Gerd A Blobel
Chromatin structure is tightly intertwined with transcription regulation. Here we compared the chromosomal architectures of fetal and adult human erythroblasts and found that, globally, chromatin structures and compartments A/B are highly similar at both developmental stages. At a finer scale, we detected distinct folding patterns at the developmentally controlled β-globin locus. Specifically, new fetal stage-specific contacts were uncovered between a region separating the fetal (γ) and adult (δ and β) globin genes (encompassing the HBBP1 and BGLT3 noncoding genes) and two distal chromosomal sites (HS5 and 3'HS1) that flank the locus...
September 15, 2017: Genes & Development
https://www.readbyqxmd.com/read/28915764/sequence-dependent-aggregation-of-peptides-and-fibril-formation
#4
Nguyen Ba Hung, Duy-Manh Le, Trinh X Hoang
Deciphering the links between amino acid sequence and amyloid fibril formation is key for understanding protein misfolding diseases. Here we use Monte Carlo simulations to study the aggregation of short peptides in a coarse-grained model with hydrophobic-polar (HP) amino acid sequences and correlated side chain orientations for hydrophobic contacts. A significant heterogeneity is observed in the aggregate structures and in the thermodynamics of aggregation for systems of different HP sequences and different numbers of peptides...
September 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28915129/atypical-exit-wound-in-high-voltage-electrocution
#5
Jamshid Parakkattil, Shanmugam Kandasamy, Siddhartha Das, Gerard Pradeep Devnath, Vinod Ashok Chaudhari, Kusa Kumar Shaha
Electrocution fatality cases are difficult to investigate. High-voltage electrocution burns resemble burns caused by other sources, especially if the person survives for few days. In that case, circumstantial evidence if correlated with the autopsy findings helps in determining the cause and manner of death. In addition, the crime scene findings also help to explain the pattern of injuries observed at autopsy. A farmer came in contact with a high-voltage transmission wire and sustained superficial to deep burns over his body...
September 14, 2017: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/28913175/regulation-of-endoplasmic-reticulum-mitochondria-ca-2-transfer-and-its-importance-for-anti-cancer-therapies
#6
REVIEW
Gaia Pedriali, Alessandro Rimessi, Luigi Sbano, Carlotta Giorgi, Mariusz R Wieckowski, Maurizio Previati, Paolo Pinton
Inter-organelle membrane contact sites are emerging as major sites for the regulation of intracellular Ca(2+) concentration and distribution. Here, extracellular stimuli operate on a wide array of channels, pumps, and ion exchangers to redistribute intracellular Ca(2+) among several compartments. The resulting highly defined spatial and temporal patterns of Ca(2+) movement can be used to elicit specific cellular responses, including cell proliferation, migration, or death. Plasma membrane (PM) also can directly contact mitochondria and endoplasmic reticulum (ER) through caveolae, small invaginations of the PM that ensure inter-organelle contacts, and can contribute to the regulation of numerous cellular functions through scaffolding proteins such as caveolins...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28904320/geometrical-effects-of-conventional-and-digital-prosthodontic-planning-wax-ups-on-lateral-occlusal-contact-number-contact-area-and-steepness
#7
Jaafar Abduo
This study evaluated and compared the effect of conventional and digital wax-ups on three lateral occlusion variables: contact number, contact area, and steepness. Dental casts of 10 patients with Angle Class I relationship were included in the study. All patients required fixed prosthodontic treatment that would affect lateral occlusion. The casts of all patients received conventional and digital wax-ups. For pretreatment, conventional wax-up, and digital wax-up casts, contact number, contact area, and occlusion steepness were measured at four lateral positions, that is, at excursions of 0...
2017: Journal of Oral Science
https://www.readbyqxmd.com/read/28903079/escalating-patterns-of-emergency-health-care-prior-to-first-admission-with-amphetamine-psychosis-a-window-of-opportunity
#8
Grant Sara, Julia Lappin, Timothy Dobbins, Adrian J Dunlop, Louisa Degenhardt
AIM: To describe health service contact in the two years prior to a first hospital admission with amphetamine-related psychosis, and to identify possible opportunities for early intervention. METHOD: Routine health data collections were used to identify 6130 persons aged 16-65 who had a first hospital admission with amphetamine-related psychosis in New South Wales (NSW), Australia, between 2005 and 2016. Health service contacts in the two years prior to first admission were identified, using public hospital, emergency department and community mental health data...
September 6, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28903010/effect-of-loading-on-in-vivo-tibiofemoral-and-patellofemoral-kinematics-of-healthy-and-acl-reconstructed-knees
#9
Jarred M Kaiser, Michael F Vignos, Richard Kijowski, Geoffrey Baer, Darryl G Thelen
BACKGROUND: Although knees that have undergone anterior cruciate ligament reconstruction (ACLR) often exhibit normal laxity on clinical examination, abnormal kinematic patterns have been observed when the joint is dynamically loaded during whole body activity. This study investigated whether abnormal knee kinematics arise with loading under isolated dynamic movements. HYPOTHESIS: Tibiofemoral and patellofemoral kinematics of ACLR knees will be similar to those of the contralateral uninjured control knee during passive flexion-extension, with bilateral differences emerging when an inertial load is applied...
September 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28902867/analysis-of-the-relationship-between-coexpression-domains-and-chromatin-3d-organization
#10
María E Soler-Oliva, Jose A Guerrero-Martínez, Valentina Bachetti, Jose C Reyes
Gene order is not random in eukaryotic chromosomes, and co-regulated genes tend to be clustered. The mechanisms that determine co-regulation of large regions of the genome and its connection with chromatin three-dimensional (3D) organization are still unclear however. Here we have adapted a recently described method for identifying chromatin topologically associating domains (TADs) to identify coexpression domains (which we term "CODs"). Using human normal breast and breast cancer RNA-seq data, we have identified approximately 500 CODs...
September 13, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28901951/real-time-non-rigid-target-tracking-for-ultrasound-guided-clinical-interventions
#11
Cornel Zachiu, Mario G Ries, Pascal Ramaekers, Jean-Luc Guey, Chrit T W Moonen, Baudouin Denis de Senneville
Biological motion is a problem for non- or mini-invasive interventions when conducted in mobile/deformable organs due to the targeted pathology moving/deforming with the organ. This may lead to high miss rates and/or incomplete treatment of the pathology. Therefore, real-time tracking of the target anatomy during the intervention would be beneficial for such applications. Since the aforementioned interventions are often conducted under B-mode ultrasound (US) guidance, target tracking can be achieved via image registration, by comparing the acquired US images to a separate image established as positional reference...
September 13, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28900539/probing-the-internal-micromechanical-properties-of-pseudomonas-aeruginosa-biofilms-by-brillouin-imaging
#12
A Karampatzakis, C Z Song, L P Allsopp, A Filloux, S A Rice, Y Cohen, T Wohland, P Török
Biofilms are organised aggregates of bacteria that adhere to each other or surfaces. The matrix of extracellular polymeric substances that holds the cells together provides the mechanical stability of the biofilm. In this study, we have applied Brillouin microscopy, a technique that is capable of measuring mechanical properties of specimens on a micrometre scale based on the shift in frequency of light incident upon a sample due to thermal fluctuations, to investigate the micromechanical properties of an active, live Pseudomonas aeruginosa biofilm...
2017: NPJ Biofilms and Microbiomes
https://www.readbyqxmd.com/read/28900393/postural-hand-synergies-during-environmental-constraint-exploitation
#13
Cosimo Della Santina, Matteo Bianchi, Giuseppe Averta, Simone Ciotti, Visar Arapi, Simone Fani, Edoardo Battaglia, Manuel Giuseppe Catalano, Marco Santello, Antonio Bicchi
Humans are able to intuitively exploit the shape of an object and environmental constraints to achieve stable grasps and perform dexterous manipulations. In doing that, a vast range of kinematic strategies can be observed. However, in this work we formulate the hypothesis that such ability can be described in terms of a synergistic behavior in the generation of hand postures, i.e., using a reduced set of commonly used kinematic patterns. This is in analogy with previous studies showing the presence of such behavior in different tasks, such as grasping...
2017: Frontiers in Neurorobotics
https://www.readbyqxmd.com/read/28898816/impaired-heel-to-toe-progression-during-gait-is-related-to-reduced-ankle-range-of-motion-in-people-with-multiple-sclerosis
#14
Michael Psarakis, David Greene, Mark Moresi, Michael Baker, Peter Stubbs, Matthew Brodie, Stephen Lord, Phu Hoang
BACKGROUND: Gait impairment in people with Multiple Sclerosis results from neurological impairment, muscle weakness and reduced range of motion. Restrictions in passive ankle range of motion can result in abnormal heel-to-toe progression (weight transfer) and inefficient gait patterns in people with Multiple Sclerosis. The purpose of this study was to determine the associations between gait impairment, heel-to-toe progression and ankle range of motion in people with Multiple Sclerosis...
September 1, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28898249/projecting-social-contact-matrices-in-152-countries-using-contact-surveys-and-demographic-data
#15
Kiesha Prem, Alex R Cook, Mark Jit
Heterogeneities in contact networks have a major effect in determining whether a pathogen can become epidemic or persist at endemic levels. Epidemic models that determine which interventions can successfully prevent an outbreak need to account for social structure and mixing patterns. Contact patterns vary across age and locations (e.g. home, work, and school), and including them as predictors in transmission dynamic models of pathogens that spread socially will improve the models' realism. Data from population-based contact diaries in eight European countries from the POLYMOD study were projected to 144 other countries using a Bayesian hierarchical model that estimated the proclivity of age-and-location-specific contact patterns for the countries, using Markov chain Monte Carlo simulation...
September 12, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28895608/surfactant-effects-on-droplet-dynamics-and-deposition-patterns-a-lattice-gas-model
#16
Narina Jung, Hae Won Seo, Perry H Leo, Jaeup Kim, Pilwon Kim, Chun Sang Yoo
A coarse-grained lattice gas model is developed to study pattern forming processes in drying drops containing surfactant. By performing Monte Carlo simulations of the model, the coupled dynamics of surfactant and liquid evaporation and the resulting oscillatory dynamics at the contact line are elucidated. We show that the coupled drop dynamics and the resulting final deposition patterns can be altered by adsorption kinetics. For slow adsorption rates, surfactant molecules recirculate along with colloidal particles and the area covered by the surfactant on the surface grows from the contact line as the initial concentration of the surfactant increases...
September 12, 2017: Soft Matter
https://www.readbyqxmd.com/read/28894989/collective-invasion-in-ductal-and-lobular-breast-cancer-associates-with-distant-metastasis
#17
Antoine A Khalil, Olga Ilina, Pavlo G Gritsenko, Peter Bult, Paul N Span, Peter Friedl
Breast cancer undergoes collective tissue invasion and, in experimental models, can collectively metastasize. The prevalence of collective invasion and its contribution to distant metastasis in clinical disease, however, remains poorly defined. We here scored the adipose tissue invasion of primary invasive ductal carcinoma (IDC), expressing E-cadherin, and E-cadherin negative invasive lobular carcinoma (ILC) and identified predominantly collective invasion patterns (86/86 samples) in both carcinoma types. Whereas collective invasion in IDC lesions retained adherens junctions, multicellular clusters and "Indian files" in ILC, despite the absence of adherens junctions (AJ) proteins E-cadherin and β-catenin, retained CD44 at cell-cell contacts...
September 11, 2017: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/28892054/long-lived-force-patterns-and-deformation-waves-at-repulsive-epithelial-boundaries
#18
Pilar Rodríguez-Franco, Agustí Brugués, Ariadna Marín-Llauradó, Vito Conte, Guiomar Solanas, Eduard Batlle, Jeffrey J Fredberg, Pere Roca-Cusachs, Raimon Sunyer, Xavier Trepat
For an organism to develop and maintain homeostasis, cell types with distinct functions must often be separated by physical boundaries. The formation and maintenance of such boundaries are commonly attributed to mechanisms restricted to the cells lining the boundary. Here we show that, besides these local subcellular mechanisms, the formation and maintenance of tissue boundaries involves long-lived, long-ranged mechanical events. Following contact between two epithelial monolayers expressing, respectively, EphB2 and its ligand ephrinB1, both monolayers exhibit oscillatory patterns of traction forces and intercellular stresses that tend to pull cell-matrix adhesions away from the boundary...
September 11, 2017: Nature Materials
https://www.readbyqxmd.com/read/28891581/femtosecond-laser-ablation-of-transparent-microphotonic-devices-and-computer-generated-holograms
#19
Tawfiq Alqurashi, Yunuen Montelongo, Pavel Penchev, Ali K Yetisen, Stefan Dimov, Haider Butt
Femtosecond laser ablation allows direct patterning of engineering materials in industrial settings without requiring multistage processes such as photolithography or electron beam lithography. However, femtosecond lasers have not been widely used to construct volumetric microphotonic devices and holograms with high reliability and cost efficiency. Here, a direct femtosecond laser writing process is developed to rapidly produce transmission 1D/2D gratings, Fresnel Zone Plate lenses, and computer-generated holograms...
September 11, 2017: Nanoscale
https://www.readbyqxmd.com/read/28889250/surface-modified-cmos-ic-electrochemical-sensor-array-targeting-single-chromaffin-cells-for-highly-parallel-amperometry-measurements
#20
REVIEW
Meng Huang, Joannalyn B Delacruz, John C Ruelas, Shailendra S Rathore, Manfred Lindau
Amperometry is a powerful method to record quantal release events from chromaffin cells and is widely used to assess how specific drugs modify quantal size, kinetics of release, and early fusion pore properties. Surface-modified CMOS-based electrochemical sensor arrays allow simultaneous recordings from multiple cells. A reliable, low-cost technique is presented here for efficient targeting of single cells specifically to the electrode sites. An SU-8 microwell structure is patterned on the chip surface to provide insulation for the circuitry as well as cell trapping at the electrode sites...
September 9, 2017: Pflügers Archiv: European Journal of Physiology
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