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https://www.readbyqxmd.com/read/29730843/effect-of-decanoic-acid-and-10-hydroxydecanoic-acid-on-the-biotransformation-of-methyl-decanoate-to-sebacic-acid
#1
Yohanes Eko Chandra Sugiharto, Heeseok Lee, Annur Dyah Fitriana, Hyeokwon Lee, Wooyoung Jeon, Kyungmoon Park, Jungoh Ahn, Hongweon Lee
Biotransformation of fatty acid methyl esters to dicarboxylic acids has attracted much attention in recent years; however, reports of sebacic acid production using such biotransformation remain few. The toxicity of decanoic acid is the main challenge for this process. Decane induction has been reported to be essential to activate the enzymes involved in the α,ω-oxidation pathway before initiating the biotransformation of methyl decanoate to sebacic acid. However, we observed the accumulation of intermediates (decanoic acid and 10-hydroxydecanoic acid) during the induction period...
May 5, 2018: AMB Express
https://www.readbyqxmd.com/read/29705291/macrophages-promote-wound-induced-hair-follicle-regeneration-in-a-cx-3-cr1-and-tgf%C3%AE-1-dependent-manner
#2
Waleed Rahmani, Yunan Liu, Nicole L Rosin, Adrienne Kline, Eko Raharjo, Jessica Yoon, Jo Anne Stratton, Sarthak Sinha, Jeff Biernaskie
Hair follicle (HF) stem cells are regulated by intrafollicular and extrafollicular niche signals. Appropriate HF regeneration relies on the coordinated release and integration of these signals. How immune cells, particularly cutaneous macrophages, influence the HF stem cell niche and regeneration is not well understood. We took advantage of wound-induced hair growth (WIHG) to explore the relationship between wound macrophages and HF regeneration. First, we show that WIHG is dependent upon CD11b+ F4/80+ macrophages between 7-11 days post-injury...
April 26, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29659045/surgical-pulmonary-embolectomy-and-catheter-directed-thrombolysis-for-treatment-of-submassive-pulmonary-embolism
#3
Ahmed A Kolkailah, Sameer Hirji, Gregory Piazza, Julius I Ejiofor, Fernando Ramirez Del Val, Jiyae Lee, Siobhan McGurk, Sary F Aranki, Prem S Shekar, Tsuyoshi Kaneko
BACKGROUND: Acute pulmonary embolism (PE) with preserved hemodynamics but right ventricular dysfunction, classified as submassive PE, carries a high risk of mortality. We report the results for patients who did not qualify for medical therapy and required treatment of submassive PE with surgical pulmonary embolectomy and catheter-directed thrombolysis (CDT). METHODS: Between October 1999 and May 2015, 133 submassive PE patients underwent treatment with pulmonary embolectomy (71) and CDT (62)...
April 16, 2018: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/29657507/initial-response-of-human-bone-marrow-derived-stem-cells-after-contact-with-ultrahigh-molecular-weight-polyethylene-uhmwpe-material-an-in-vitro-study-on-cell-viability-and-interleukin-6-expression
#4
Iwan B Anwar, Asep Santoso, Eko Saputra, Rifky Ismail, J Jamari, Emile van der Heide
Introduction: Ultrahigh-molecular-weight polyethylene (UHMWPE) is a thermoplastic polymer useful in biomaterial applications, especially in orthopedic field. Yet, little is known concerning its initial effect on human bone marrow stem cells (hBMSCs) after implantation. Materials and Methods: A cytotoxicity analysis was performed with a 3-(4,5-dimethylthiazol 2-yl)-2,5-diphenyltetrazolium assay after 24, 48, and 72h of incubation of hBMSC culture. Expression of interleukin-6 (IL-6) was measured using enzyme-linked immunosorbent assay...
January 2018: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29652917/prevalent-hepatitis-b-surface-antigen-among-first-time-blood-donors-in-gabon
#5
Jean Marie Eko Mba, Cyrille Bisseye, Jophrette Mireille Ntsame Ndong, Landry Erik Mombo, Calixte Bengone, Guy Mouelet Migolet, Bertrand M'batchi, Heidi E Kosiorek, Richard J Butterfield, Lewis R Roberts, Mitesh J Borad, Bolni Marius Nagalo
Despite chronic Hepatitis B virus (HBV) infection being the main cause of younger-onset complex liver disease including cirrhosis and hepatocellular carcinoma (HCC) in Africa, very little is known regarding the seroprevalence of HBV in the Gabonese general population. This investigation aimed to provide strong epidemiological data and risk factors associated with HBV infection in first-time blood donors representative of the urban adult population. The screening of HBsAg was carried out using 4th generation ELISA kits...
2018: PloS One
https://www.readbyqxmd.com/read/29650090/screening-for-diabetes-in-adults
#6
Jean-Marie Ekoe, Ronald Goldenberg, Pamela Katz
No abstract text is available yet for this article.
April 2018: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/29644012/abundance-fishing-season-and-management-strategy-for-blue-swimming-crab-portunus-pelagicus-in-pangkajene-kepulauan-south-sulawesi-indonesia
#7
Eko Sri Wiyono, Ihsan
In order to manage blue swimming crabs in Pangkajene Kepulauan, management measures are required. Since the environment which affects the abundance of the blue swimming crab varies seasonally, it is necessary to take into account the seasonal nature with the aim of developing a management strategy. The objectives of this study are to define the abundance of and fishing season of blue swimming crabs in the Pangkajene Kepulauan waters, South Sulawesi, Indonesia. The fishing season was analysed using seasonal index analysis, while fish abundance was analysed by means of Equilibrium-Schaefer...
March 2018: Tropical Life Sciences Research
https://www.readbyqxmd.com/read/29642565/polyacrylonitrile-nanofiber-based-quartz-crystal-microbalance-for-sensitive-detection-of-safrole
#8
Aditya Rianjanu, Roto Roto, Trisna Julian, Shidiq Nur Hidayat, Ahmad Kusumaatmaja, Eko Agus Suyono, Kuwat Triyana
Safrole is the main precursor for producing the amphetamine-type stimulant (ATS) drug, N -methyl-3,4-methylenedioxyamphetamine (MDMA), also known as ecstasy. We devise a polyacrylonitrile (PAN) nanofiber-based quartz crystal microbalance (QCM) for detecting safrole. The PAN nanofibers were fabricated by direct electrospinning to modify the QCM chips. The PAN nanofiber on the QCM chips has a diameter of 240 ± 10 nm. The sensing of safrole by QCM modified with PAN nanofiber shows good reversibility and an apparent sensitivity of 4...
April 10, 2018: Sensors
https://www.readbyqxmd.com/read/29580671/intron-retained-transcripts-of-the-spinal-muscular-atrophy-genes-smn1-and-smn2
#9
Nur Imma Fatimah Harahap, Emma Tabe Eko Niba, Mawaddah Ar Rochmah, Yogik Onky Silvana Wijaya, Toshio Saito, Kayoko Saito, Hiroyuki Awano, Ichiro Morioka, Kazumoto Iijima, Poh San Lai, Masafumi Matsuo, Hisahide Nishio, Masakazu Shinohara
BACKGROUND: The SMN genes, SMN1 and SMN2, are highly homologous genes which are related to the development or clinical severity of spinal muscular atrophy. Some alternative splicing patterns of the SMN genes have been well documented. In 2007, an SMN1 transcript with a full sequence of intron 3 was reported as the first intron-retained SMN transcript. METHODS: Intron-retained SMN transcripts in various cells and tissues were studied using reverse transcription (RT)-PCR...
March 23, 2018: Brain & Development
https://www.readbyqxmd.com/read/29541679/characterization-of-a-mixture-of-algae-waste-bentonite-used-as-adsorbent-for-the-removal-of-pb2-from-aqueous-solution
#10
Eko Prasetyo Kuncoro, Thin Soedarti, Trisnadi Widyaleksono Catur Putranto, Handoko Darmokoesoemo, Nanda Rizki Abadi, Heri Septya Kusuma
The usage of wastes of algae would be admirable from environmental and solid waste management point of view. Thus, herein, this data set present a facile method for providing an adsorbent from mixture of algae waste-bentonite. The prepared adsorbent was applied to remove Pb2+ from aqueous solution. The characterization data of the adsorbent were analyzed using FTIR and SEM-EDX methods. The FTIR test results showed that there is a shift in the wave numbers on the adsorbent that has been loaded with Pb indicating that there is an interaction between the adsorbent and Pb...
February 2018: Data in Brief
https://www.readbyqxmd.com/read/29487650/ekosonic-endovascular-system-ekos-in-a-trauma-patient-with-intracranial-bleed-recent-major-surgery-and-massive-pulmonary-embolus-a-case-report
#11
Steve M Nelson, Steven H Craig
Pulmonary embolism is a life-threatening condition treated with anticoagulation and systemic thrombolysis when appropriate. In patients with contraindications to thrombolysis, catheter-directed thrombolysis may be considered. Here, we present a patient with massive pulmonary embolus and 3 contraindications to systemic thrombolysis who was successfully treated with pharmacomechanical thrombolysis using the Ekosonic Endovascular System.
February 2018: Radiology case reports
https://www.readbyqxmd.com/read/29453649/reinereins-a-and-b-new-onocerane-triterpenoids-from-reinwardtiodendron-cinereum
#12
Alfarius Eko Nugroho, Daisuke Inoue, Chin Piow Wong, Yusuke Hirasawa, Toshio Kaneda, Osamu Shirota, A Hamid A Hadi, Hiroshi Morita
Bioactivity guided separation of Reinwardtiodendron cinereum barks methanol extract led to the isolation of two new onocerane triterpenoids, reinereins A and B (1 and 2), together with three known onocerane triterpenoids. Their structures were elucidated on the basis of NMR spectroscopic data. In vitro cytotoxic activities of the isolated compounds against several type of cancer cells were evaluated.
March 2018: Journal of Natural Medicines
https://www.readbyqxmd.com/read/29434179/sma-diagnosis-detection-of-smn1-deletion-with-real-time-mcop-pcr-system-using-fresh-blood-dna
#13
Emma Tabe Eko Niba, Mawaddah Ar Rochmah, Nur Imma Fatimah Harahap, Hiroyuki Awano, Ichiro Morioka, Kazumoto Iijima, Toshio Saito, Kayoko Saito, Atsuko Takeuchi, Poh San Lai, Yoshihiro Bouike, Hisahide Nishio, Masakazu Shinohara
BACKGROUND: Spinal muscular atrophy (SMA) is one of the most common autosomal recessive disorders. The symptoms are caused by defects of lower motor neurons in the spinal cord. More than 95% of SMA patients are homozygous for survival motor neuron 1 (SMN1) deletion. We previously developed a screening system for SMN1 deletion based on a modified competitive oligonucleotide priming-PCR (mCOP-PCR) technique using dried blood spot (DBS) on filter paper. This system is convenient for mass screening in the large population and/or first-tier diagnostic method of the patients in the remote areas...
December 18, 2017: Kobe Journal of Medical Sciences
https://www.readbyqxmd.com/read/29434173/gender-effects-on-the-clinical-phenotype-in-japanese-patients-with-spinal-muscular-atrophy
#14
Mawaddah Ar Rochmah, Ai Shima, Nur Imma Fatimah Harahap, Emma Tabe Eko Niba, Naoya Morisada, Shinichiro Yanagisawa, Toshio Saito, Kaori Kaneko, Kayoko Saito, Ichiro Morioka, Kazumoto Iijima, Poh San Lai, Yoshihiro Bouike, Hisahide Nishio, Masakazu Shinohara
BACKGROUND: Spinal muscular atrophy (SMA) is a neuromuscular disease caused by a mutation in SMN1. SMA is classified into three subtypes (types 1, 2, 3) based on achieved motor milestones. Although NAIP and SMN2 are widely accepted as SMA-modifying factors, gender-related modifying factors or gender effects on the clinical phenotype are still controversial. METHODS: A total of 122 Japanese patients with SMA, of which SMN1 was homozygously deleted, were analyzed from the perspective of the achieved motor milestone, NAIP status and SMN2 copy number...
October 16, 2017: Kobe Journal of Medical Sciences
https://www.readbyqxmd.com/read/29434172/new-improved-version-of-the-mcop-pcr-screening-system-for-detection-of-spinal-muscular-atrophy-gene-smn1-deletion
#15
Masakazu Shinohara, Mawaddah Ar Rochmah, Kenta Nakanishi, Nur Imma Fatimah Harahap, Emma Tabe Eko Niba, Toshio Saito, Kayoko Saito, Atsuko Takeuchi, Yoshihiro Bouike, Hisahide Nishio
BACKGROUND: Spinal muscular atrophy (SMA) is a frequent autosomal recessive disorder, characterized by lower motor neuron loss in the spinal cord. More than 95% of SMA patients show homozygous survival motor neuron 1 (SMN1) deletion. We previously developed a screening system for SMN1 deletion based on a modified competitive oligonucleotide priming-PCR (mCOP-PCR) technique. However, non-specific amplification products were observed with mCOP-PCR, which might lead to erroneous interpretation of the screening results...
September 7, 2017: Kobe Journal of Medical Sciences
https://www.readbyqxmd.com/read/29417407/a-systematic-review-of-ultrasound-accelerated-catheter-directed-thrombolysis-in-the-treatment-of-deep-vein-thrombosis
#16
REVIEW
Yadong Shi, Wanyin Shi, Liang Chen, Jianping Gu
To review the clinical evidence for ultrasound-accelerated catheter-directed thrombolysis (UACDT) using the EKOS system in the treatment of deep vein thrombosis (DVT) in terms of case selection, procedural outcomes, clinical outcomes and safety outcomes. A systematic literature search strategy was used to identify the use of the EKOS system in the treatment of DVT using the following electronic databases: MEDLINE, EMBASE, the Cochrane databases and the Web of Science. The references in the relevant literature were also screened...
April 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29378408/small-molecule-inhibitors-of-the-pcsk9%C3%A2-ldlr-interaction
#17
Jaru Taechalertpaisarn, Bosheng Zhao, Xiaowen Liang, Kevin Burgess
The protein-protein interaction between proprotein convertase subtilisin/kexin type 9 (PCSK9) and low-density lipoprotein receptor (LDLR) is a relatively new, and extremely important, validated therapeutic target for treatment and prevention of heart disease. Experts in the area agree that the first small molecules to disrupt PCSK9·LDLR would represent a milestone in this field, yet few credible leads have been reported. This paper describes how side-chain orientations in preferred conformations of carefully designed chemotypes were compared with LDLR side chains at the PCSK9·LDLR interface to find molecules that would mimic interface regions of LDLR...
March 7, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29317920/indonesian-pharmacists-and-pharmacy-students-attitudes-towards-collaboration-with-physicians
#18
Adji P Setiadi, Yosi Wibowo, Sylvi Irawati, Eko Setiawan, Bobby Presley, Sajni Gudka, Ari S Wardhani
Background: Recent implementation of national health coverage and the increasing health burden in Indonesia require health professionals, including pharmacists, to work more collaboratively to improve access and quality of health care. Nevertheless, relatively little is known about Indonesian pharmacists' attitude towards collaboration. Objective: To assess and compare the attitude of Indonesian pharmacy students and pharmacists towards collaboration with physicians...
October 2017: Pharmacy Practice
https://www.readbyqxmd.com/read/29276738/characterization-kinetic-and-isotherm-data-for-adsorption-of-pb-2-from-aqueous-solution-by-adsorbent-from-mixture-of-bagasse-bentonite
#19
Eko Prasetyo Kuncoro, Dwi Ratri Mitha Isnadina, Handoko Darmokoesoemo, Oktiani Rahmanita Fauziah, Heri Septya Kusuma
The usage of wastes of bagasse would be admirable from environmental and solid waste management point of view. Thus, herein, this data set present a facile method for providing an adsorbent from mixture of bagasse-bentonite. The prepared adsorbent was applied to remove Pb2+ from aqueous solution. It was conducted in laboratory scale using completely randomized design with variations in mixed mass ratio (1:0, 1:1, 1:2, 1:3, 2:1, 3:1), pH (2, 3, 4, 5, 6, 7) and contact time (5, 10, 30, 45, 90, 120, 180 min) and the adsorption technique was batch technique...
February 2018: Data in Brief
https://www.readbyqxmd.com/read/29234692/characterization-and-isotherm-data-for-adsorption-of-cd-2-from-aqueous-solution-by-adsorbent-from-mixture-of-bagasse-bentonite
#20
Eko Prasetyo Kuncoro, Dwi Ratri Mitha Isnadina, Handoko Darmokoesoemo, Fembriany Dzembarahmatiny, Heri Septya Kusuma
The usage of wastes of baggase would be admirable from environmental and solid waste management point of view. Thus, herein, this data set present a facile method for providing an adsorbent from mixture of bagasse-bentonite. The prepared adsorbent was applied to remove Cd2+ from aqueous solution. The characterization data of the adsorbent were analyzed using XRF and FTIR methods. The XRF test results showed the changes of elemental content in adsorbent after the adsorption indicated that adsorbent can absorb Cd2+ ...
February 2018: Data in Brief
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