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https://www.readbyqxmd.com/read/29317920/indonesian-pharmacists-and-pharmacy-students-attitudes-towards-collaboration-with-physicians
#1
Adji P Setiadi, Yosi Wibowo, Sylvi Irawati, Eko Setiawan, Bobby Presley, Sajni Gudka, Ari S Wardhani
Background: Recent implementation of national health coverage and the increasing health burden in Indonesia require health professionals, including pharmacists, to work more collaboratively to improve access and quality of health care. Nevertheless, relatively little is known about Indonesian pharmacists' attitude towards collaboration. Objective: To assess and compare the attitude of Indonesian pharmacy students and pharmacists towards collaboration with physicians...
October 2017: Pharmacy Practice
https://www.readbyqxmd.com/read/29276738/characterization-kinetic-and-isotherm-data-for-adsorption-of-pb2-from-aqueous-solution-by-adsorbent-from-mixture-of-bagasse-bentonite
#2
Eko Prasetyo Kuncoro, Dwi Ratri Mitha Isnadina, Handoko Darmokoesoemo, Oktiani Rahmanita Fauziah, Heri Septya Kusuma
The usage of wastes of bagasse would be admirable from environmental and solid waste management point of view. Thus, herein, this data set present a facile method for providing an adsorbent from mixture of bagasse-bentonite. The prepared adsorbent was applied to remove Pb2+ from aqueous solution. It was conducted in laboratory scale using completely randomized design with variations in mixed mass ratio (1:0, 1:1, 1:2, 1:3, 2:1, 3:1), pH (2, 3, 4, 5, 6, 7) and contact time (5, 10, 30, 45, 90, 120, 180 min) and the adsorption technique was batch technique...
February 2018: Data in Brief
https://www.readbyqxmd.com/read/29234692/characterization-and-isotherm-data-for-adsorption-of-cd2-from-aqueous-solution-by-adsorbent-from-mixture-of-bagasse-bentonite
#3
Eko Prasetyo Kuncoro, Dwi Ratri Mitha Isnadina, Handoko Darmokoesoemo, Fembriany Dzembarahmatiny, Heri Septya Kusuma
The usage of wastes of baggase would be admirable from environmental and solid waste management point of view. Thus, herein, this data set present a facile method for providing an adsorbent from mixture of bagasse-bentonite. The prepared adsorbent was applied to remove Cd2+ from aqueous solution. The characterization data of the adsorbent were analyzed using XRF and FTIR methods. The XRF test results showed the changes of elemental content in adsorbent after the adsorption indicated that adsorbent can absorb Cd2+...
February 2018: Data in Brief
https://www.readbyqxmd.com/read/29216217/the-emerging-role-of-asc-in-dendritic-cell-metabolism-during-chlamydia-infection
#4
Danielle N McKeithen, Yusuf O Omosun, Khamia Ryans, Jing Mu, Zhonglin Xie, Tankya Simoneaux, Uriel Blas-Machado, Francis O Eko, Carolyn M Black, Joseph U Igietseme, Qing He
Chlamydia trachomatis is a bacterial agent that causes sexually transmitted infections worldwide. The regulatory functions of dendritic cells (DCs) play a major role in protective immunity against Chlamydia infections. Here, we investigated the role of ASC in DCs metabolism and the regulation of DCs activation and function during Chlamydia infection. Following Chlamydia stimulation, maturation and antigen presenting functions were impaired in ASC-/- DCs compared to wild type (WT) DCs, in addition, ASC deficiency induced a tolerant phenotype in Chlamydia stimulated DCs...
2017: PloS One
https://www.readbyqxmd.com/read/29206479/microencapsulation-of-esterified-krill-oil-using-complex-coacervation
#5
Selim Kermasha, Sarya Aziz, Jagpreet Gill, Ronald Neufeld
The microencapsulation of the esterified krill oil (EKO), obtained from the transesterification of krill oil (KO) with 3,4-dihydroxyphenylacetic acid (DHPA), via complex coacervation, was investigated. The experimental findings showed that the DHPA and phenolic lipids (PLs) in the EKO affected the stability of the gelatin (GE)-EKO emulsion. To improve its stability, the effects of varying the pH of GE and the use of two emulsification devices, including the homogenizer and ultrasonic liquid processor were investigated, where the ultrasonic liquid processor was found to be a relatively more appropriate emulsification device...
December 5, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29196124/combined-engineering-of-disaccharide-transport-and-phosphorolysis-for-enhanced-atp-yield-from-sucrose-fermentation-in-saccharomyces-cerevisiae
#6
Wesley Leoricy Marques, Robert Mans, Ryan K Henderson, Eko Roy Marella, Jolanda Ter Horst, Erik de Hulster, Bert Poolman, Jean-Marc Daran, Jack T Pronk, Andreas K Gombert, Antonius J A van Maris
Anaerobic industrial fermentation processes do not require aeration and intensive mixing and the accompanying cost savings are beneficial for production of chemicals and fuels. However, the free-energy conservation of fermentative pathways is often insufficient for the production and export of the desired compounds and/or for cellular growth and maintenance. To increase free-energy conservation during fermentation of the industrially relevant disaccharide sucrose by Saccharomyces cerevisiae, we first replaced the native yeast α-glucosidases by an intracellular sucrose phosphorylase from Leuconostoc mesenteroides (LmSPase)...
November 28, 2017: Metabolic Engineering
https://www.readbyqxmd.com/read/29171448/vitamin-d-cell-death-pathways-and-tuberculosis
#7
Manik Retno Wahyunitisari, Ni Made Mertaniasih, Muhammad Amin, Wayan T Artama, Eko B Koendhori
BACKGROUND: Mycobacterium tuberculosis induces cellular necrosis that could promote spread of infection. The aim of this study is to analyze the effects of Vitamin D3 supplementation to improve the effectiveness of 2nd-line anti-tuberculosis (TB) drug therapy, especially in relation with cell death pathways. METHODS: Mus musculus C3HeB/FeJ was randomly divided into four groups containing eight animals each. The 1st group (G1), consisting of mice that were intratracheally infected with multidrug-resistant strain of M...
October 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/29159598/etox-allies-an-automated-pipeline-for-linear-interaction-energy-based-simulations
#8
Luigi Capoferri, Marc van Dijk, Ariën S Rustenburg, Tsjerk A Wassenaar, Derk P Kooi, Eko A Rifai, Nico P E Vermeulen, Daan P Geerke
BACKGROUND: Computational methods to predict binding affinities of small ligands toward relevant biological (off-)targets are helpful in prioritizing the screening and synthesis of new drug candidates, thereby speeding up the drug discovery process. However, use of ligand-based approaches can lead to erroneous predictions when structural and dynamic features of the target substantially affect ligand binding. Free energy methods for affinity computation can include steric and electrostatic protein-ligand interactions, solvent effects, and thermal fluctuations, but often they are computationally demanding and require a high level of supervision...
November 21, 2017: Journal of Cheminformatics
https://www.readbyqxmd.com/read/29110723/molecular-and-serological-detection-of-bovine-babesiosis-in-indonesia
#9
Azirwan Guswanto, Puttik Allamanda, Euis Siti Mariamah, Sodirun Sodirun, Putut Eko Wibowo, Liliek Indrayani, Rudi Harso Nugroho, I Ketut Wirata, Nur Jannah, Lepsi Putri Dias, Hadi Purnama Wirawan, Rochmadi Yanto, Bumduuren Tuvshintulga, Thillaiampalam Sivakumar, Naoaki Yokoyama, Ikuo Igarashi
BACKGROUND: Bovine babesiosis, mainly caused by Babesia bovis and B. bigemina, is a huge threat to the livestock industry. In Indonesia, the current distribution of the disease is unknown due to a lack of scientific study. METHODS: In the present study, 487 blood samples were collected from cattle with different breeding and age groups in a broad geographical area across the archipelago. The presence of antibodies and current infections of B. bovis and B. bigemina were determined using enzyme-linked immunosorbent assay (ELISA), immunochromatographic test (ICT), and nested PCR (nPCR) targeting B...
November 6, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29101852/engineering-microbial-fatty-acid-metabolism-for-biofuels-and-biochemicals
#10
REVIEW
Eko Roy Marella, Carina Holkenbrink, Verena Siewers, Irina Borodina
Traditional oleochemical industry chemically processes animal fats and plant oils to produce detergents, lubricants, biodiesel, plastics, coatings, and other products. Biotechnology offers an alternative process, where the same oleochemicals can be produced from abundant biomass feedstocks using microbial catalysis. This review summarizes the recent advances in the engineering of microbial metabolism for production of fatty acid-derived products. We highlight the efforts in engineering the central carbon metabolism, redox metabolism, controlling the chain length of the products, and obtaining metabolites with different functionalities...
November 1, 2017: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/29101528/a-novel-variant-of-narrow-spectrum-antifungal-bacterial-lipopeptides-that-strongly-inhibit-ganoderma-boninense
#11
Theodorus Eko Pramudito, Delia Agustina, Thi Kim Ngan Nguyen, Antonius Suwanto
Bacterial antifungal cyclic lipopeptides (ACLs) have become a promising alternative to synthetic fungicide to control pathogenic fungi. Bacillus sp. is known to produce three families of ACL, namely iturin, surfactin, and fengycin. In this paper, we characterized the ACLs produced by B. methylotrophicus HC51 (referred as HC51) mainly regarding its composition and effectivity against fungal plant pathogen. HC51 culture was tested against various pathogenic fungi and the ACLs were extracted and analyzed using liquid chromatography-electrospray ionization mass spectrometry...
November 3, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/29038160/a-high-resolution-genome-wide-crispr-cas9-viability-screen-reveals-structural-features-and-contextual-diversity-of-the-human-cell-essential-proteome
#12
Thierry Bertomeu, Jasmin Coulombe-Huntington, Andrew Chatr-Aryamontri, Karine Bourdages, Etienne Coyaud, Brian Raught, Yu Xia, Mike Tyers
To interrogate genes essential for cell growth, proliferation and survival in human cells, we carried out a genome-wide CRISPR/Cas9 screen in a B-cell lymphoma line using a custom extended knockout (EKO) library of 278,754 sgRNAs that targeted 19,084 RefSeq genes, 20,852 alternatively-spliced exons and 3,872 hypothetical genes. A new statistical analysis tool called RANKS identified 2,280 essential genes, 234 of which were unique. Individual essential genes were validated experimentally and linked to ribosome biogenesis and stress responses...
October 16, 2017: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28966304/the-profile-of-mmp-9-mmp-9-mrna-expression-1562-c-t-polymorphism-and-outcome-in-high-risk-traumatic-brain-injury-the-effect-of-therapeutic-mild-hypothermia
#13
Eko Prasetyo, Andi Asadul Islam, Mochammad Hatta, Djoko Widodo, Ilhamjaya Pattelongi
The aim of this study was to investigate the effect of mild hypothermia therapy (34-36°C) and the alterations of matrix metalloproteinase-9 (MMP-9) in 20 patients with high-risk traumatic brain injury (TBI). The neurologic status and outcome were assessed using Full Outline of UnResponsiveness (FOUR) score and Glasgow Coma Scale (GCS). A prospective randomized control study involved patients with high-risk TBI (FOUR score ≤ 7). Patients were randomized into two groups, with and without mild hypothermia therapy which were investigated within 24 and 72 h...
October 2, 2017: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/28959956/apoe4-markedly-exacerbates-tau-mediated-neurodegeneration-in-a-mouse-model-of-tauopathy
#14
Yang Shi, Kaoru Yamada, Shane Antony Liddelow, Scott T Smith, Lingzhi Zhao, Wenjie Luo, Richard M Tsai, Salvatore Spina, Lea T Grinberg, Julio C Rojas, Gilbert Gallardo, Kairuo Wang, Joseph Roh, Grace Robinson, Mary Beth Finn, Hong Jiang, Patrick M Sullivan, Caroline Baufeld, Michael W Wood, Courtney Sutphen, Lena McCue, Chengjie Xiong, Jorge L Del-Aguila, John C Morris, Carlos Cruchaga, Anne M Fagan, Bruce L Miller, Adam L Boxer, William W Seeley, Oleg Butovsky, Ben A Barres, Steven M Paul, David M Holtzman
APOE4 is the strongest genetic risk factor for late-onset Alzheimer disease. ApoE4 increases brain amyloid-β pathology relative to other ApoE isoforms. However, whether APOE independently influences tau pathology, the other major proteinopathy of Alzheimer disease and other tauopathies, or tau-mediated neurodegeneration, is not clear. By generating P301S tau transgenic mice on either a human ApoE knock-in (KI) or ApoE knockout (KO) background, here we show that P301S/E4 mice have significantly higher tau levels in the brain and a greater extent of somatodendritic tau redistribution by three months of age compared with P301S/E2, P301S/E3, and P301S/EKO mice...
September 28, 2017: Nature
https://www.readbyqxmd.com/read/28929288/complex-organic-pollutant-mixtures-originating-from-industrial-and-municipal-emissions-in-surface-waters-of-the-megacity-jakarta-an-example-of-a-water-pollution-problem-in-emerging-economies
#15
Larissa Dsikowitzky, Lukas Hagemann, Dwiyitno, Farida Ariyani, Hari Eko Irianto, Jan Schwarzbauer
During the last decades, the global industrial production partly shifted from industrialized nations to emerging and developing countries. In these upcoming economies, the newly developed industrial centers are generally located in densely populated areas, resulting in the discharge of often only partially treated industrial and municipal wastewaters into the surface waters. There is a huge gap of knowledge about the composition of the complex organic pollutant mixtures occurring in such heavily impacted areas...
September 19, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28913679/erratum-to-towards-robot-assisted-echocardiographic-monitoring-in-catheterization-laboratories-usability-centered-manipulator-for-transesophageal-echocardiography
#16
Christina Pahl, Henning Ebelt, Mostafa Sayahkarajy, Eko Supriyanto, Amiliana Soesanto
No abstract text is available yet for this article.
November 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28893911/molecular-and-functional-characterization-of-the-endothelial-atp-sensitive-potassium-channel
#17
Qadeer Aziz, Yiwen Li, Naomi Anderson, Leona Ojake, Elena Tsisanova, Andrew Tinker
ATP-sensitive potassium (KATP) channels are widely expressed in the cardiovascular system, where they regulate a range of biological activities by linking cellular metabolism with membrane excitability. KATP channels in vascular smooth muscle have a well-defined role in regulating vascular tone. KATP channels are also thought to be expressed in vascular endothelial cells, but their presence and function in this context are less clear. As a result, we aimed to investigate the molecular composition and physiological role of endothelial KATP channels...
October 27, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28893538/indispensable-role-of-lipoprotein-bound-apoe-in-adipogenesis-and-endocytosis-induced-by-postprandial-trl
#18
Mingyu Zhang, Yanhong Li, Xuehong Wei, Feng Tian, Fan Ouyang, Shuiping Zhao, Ling Liu
Diet-associated obesity is coexisted with postprandial hypertriglyceridemia that indicates increased number of triglyceride-rich lipoproteins (TRL). This study aimed to investigate the effect of postprandial TRL-bound apolipoprotein E (ApoE) on adipogenesis and potential mechanisms. 3T3-L1 cells were cultured with (i) human TRL (h-TRL) with or without insulin, or (ii) TRL from wild type mice (WT-TRL) or ApoE knock-out mice (EKO-TRL) and insulin. The differentiating adipocytes were incubated with different kinds of TRL labeled by red fluorescence and confocal microscopy was performed...
November 4, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28889350/binding-free-energy-predictions-of-farnesoid-x-receptor-fxr-agonists-using-a-linear-interaction-energy-lie-approach-with-reliability-estimation-application-to-the-d3r-grand-challenge-2
#19
Eko Aditya Rifai, Marc van Dijk, Nico P E Vermeulen, Daan P Geerke
Computational protein binding affinity prediction can play an important role in drug research but performing efficient and accurate binding free energy calculations is still challenging. In the context of phase 2 of the Drug Design Data Resource (D3R) Grand Challenge 2 we used our automated eTOX ALLIES approach to apply the (iterative) linear interaction energy (LIE) method and we evaluated its performance in predicting binding affinities for farnesoid X receptor (FXR) agonists. Efficiency was obtained by our pre-calibrated LIE models and molecular dynamics (MD) simulations at the nanosecond scale, while predictive accuracy was obtained for a small subset of compounds...
September 9, 2017: Journal of Computer-aided Molecular Design
https://www.readbyqxmd.com/read/28822030/ceramicines-m-p-from-chisocheton-ceramicus-isolation-and-structure-activity-relationship-study
#20
Alfarius Eko Nugroho, Akiyo Hashimoto, Chin-Piow Wong, Hiromasa Yokoe, Masayoshi Tsubuki, Toshio Kaneda, A Hamid A Hadi, Hiroshi Morita
Ceramicines are a series of limonoids which were isolated from the bark of Malaysian Chisocheton ceramicus (Meliaceae) and show various biological activities. Ceramicine B, in particular, has been reported to show a strong lipid droplet accumulation (LDA) inhibitory activity on a mouse pre-adipocyte cell line (MC3T3-G2/PA6). With the purpose of discovering compounds with stronger activity than ceramicine B, we further investigated the constituents of C. ceramicus. As a result, from the bark of C. ceramicus four new ceramicines (ceramicines M-P, 1-4) were isolated, and their structures were determined on the basis of NMR and mass spectroscopic analyses in combination with NMR chemical shift calculations...
August 18, 2017: Journal of Natural Medicines
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