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https://www.readbyqxmd.com/read/28206731/thrombus-resolution-and-right-ventricular-functional-recovery-using-ultrasound-accelerated-thrombolysis-in-acute-massive-and-submassive-pulmonary-embolism
#1
Evren Ozcinar, Mehmet Cakici, Nur Dikmen Yaman, Cagdas Baran, Anar Aliyev, Bahadir Inan, Serkan Durdu, Ahmet R Akar, Mustafa Sirlak
BACKGROUND: This study aims to evaluate the efficacy and safety of ultrasound-accelerated catheter- directed thrombolysis (UACDT) in the treatment of massive and submassive pulmonary embolism (PE). METHODS: We conducted a prospective, observational cohort study of consequtive patients with massive or submassive PE treated with low-dose UACDT using EKOS EkoSonic® system at single center from May 2014 until April 2015. Overall, thirty-eight patients (median age, 64...
February 15, 2017: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/28191777/enhanced-expansion-and-sustained-inductive-function-of-skin-derived-precursor-cells-in-computer-controlled-stirred-suspension-bioreactors
#2
Natacha A Agabalyan, Breanna S Borys, Holly D Sparks, Kathryn Boon, Eko W Raharjo, Sepideh Abbasi, Michael S Kallos, Jeff Biernaskie
Endogenous dermal stem cells (DSCs) reside in the adult hair follicle mesenchyme and can be isolated and grown in vitro as self-renewing colonies called skin-derived precursors (SKPs). Following transplantation into skin, SKPs can generate new dermis and reconstitute the dermal papilla and connective tissue sheath, suggesting they could have important therapeutic value for the treatment of skin disease (alopecia) or injury. Controlled cell culture processes must be developed to efficiently and safely generate sufficient stem cell numbers for clinical use...
February 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28100912/cryptic-splice-activation-but-not-exon-skipping-is-observed-in-minigene-assays-of-dystrophin-c-9361-1g-a-mutation-identified-by-ngs
#3
Emma Tabe Eko Niba, Atsushi Nishida, Van Khanh Tran, Dung Chi Vu, Masaaki Matsumoto, Hiroyuki Awano, Tomoko Lee, Yasuhiro Takeshima, Hisahide Nishio, Masafumi Matsuo
Next-generation sequencing (NGS) discloses nucleotide changes in the genome. Mutations at splicing regulatory elements are expected to cause splicing errors, such as exon skipping, cryptic splice site activation, partial exon loss or intron retention. In dystrophinopathy patients, prediction of splicing outcomes is essential to determine the phenotype: either severe Duchenne or mild Becker muscular dystrophy, based on the reading frame rule. In a Vietnamese patient, NGS identified a c.9361+1G>A mutation in the dystrophin gene and an additional DNA variation of A>G at +117 bases in intron 64...
January 19, 2017: Journal of Human Genetics
https://www.readbyqxmd.com/read/28087672/elimination-of-sucrose-transport-and-hydrolysis-in-saccharomyces-cerevisiae-a-platform-strain-for-engineering-sucrose-metabolism
#4
Wesley Leoricy Marques, Robert Mans, Eko Roy Marella, Rosa Lorizolla Cordeiro, Marcel van den Broek, Jean-Marc G Daran, Jack T Pronk, Andreas K Gombert, Antonius J A van Maris
Many relevant options to improve efficacy and kinetics of sucrose metabolism in Saccharomyces cerevisiae and, thereby, the economics of sucrose-based processes, remain to be investigated. An essential first step is to identify all native sucrose-hydrolysing enzymes and sucrose transporters in this yeast, including those that can be activated by suppressor mutations in sucrose-negative strains. A strain in which all known sucrose-transporter genes (MAL11, MAL21, MAL31, MPH2, MPH3) were deleted did not grow on sucrose after 2 months of incubation...
January 12, 2017: FEMS Yeast Research
https://www.readbyqxmd.com/read/28044155/proton-driven-coordination-induced-spin-state-switch-pd-cisss-of-iron-ii-complexes
#5
René Nowak, Eko Adi Prasetyanto, Luisa De Cola, Beate Bojer, Renée Siegel, Jürgen Senker, Ernst Rössler, Birgit Weber
Here we report the completely reversible spin state switch of the naturally diamagnetic tris(bipyridine)iron(ii) complex and the spin crossover complex bis(2,6-bis(1H-pyrazol-3-yl)pyridine)iron(ii) by the variation of the pH followed by (1)H-NMR, UV-Vis spectroscopy, and magnetic and relaxivity measurements in solution and as composite materials encapsulated in a zeolite matrix.
January 3, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28008280/thicker-carotid-intima-media-thickness-and-increased-plasma-vegf-levels-suffered-by-post-acute-thrombotic-stroke-patients
#6
Yuyun Yueniwati, Ni Komang Darmiastini, Eko Arisetijono
BACKGROUND AND OBJECTIVES: Atherosclerosis causes reduction of the oxygen supply to structures in the far arterial wall, provoking the release of factors that drive angiogenesis of vasa vasorum, including VEGF. Other studies have revealed the inflammatory response in atherosclerosis and the role of platelet factor 4 (PF4) as an anti-angiogenic chemokine through the inhibition of VEGF. This cross-sectional study aims at measuring the effect of atherosclerosis assessed through carotid intima-media thickness (CIMT) against plasma VEGF levels in patients with post-acute thrombotic stroke...
2016: International Journal of General Medicine
https://www.readbyqxmd.com/read/27932618/the-roles-of-unfolded-protein-response-pathways-in-chlamydia-pathogenesis
#7
Zenas George, Yusuf Omosun, Anthony A Azenabor, James Partin, Kahaliah Joseph, Debra Ellerson, Qing He, Francis Eko, Claudiu Bandea, Pavel Svoboda, Jan Pohl, Carolyn M Black, Joseph U Igietseme
Chlamydia is an obligate intracellular bacterium that relies on host cell for essential nutrients and ATP for a productive infection. Although the unfolded protein response (UPR) plays a major role in certain microbial infectivity, its role in chlamydial pathogenesis is unknown. We hypothesized that Chlamydia induces UPR and exploits it to upregulate host cell uptake and metabolism of glucose, production of ATP, phospholipids and other molecules required for its replicative development and host survival. Using a combination of biochemical and pathway inhibition assays, we showed that the three UPR pathway transducers: Protein kinase RNA-activated (PKR)-like ER kinase (PERK), Inositol-requiring enzyme-1α (IRE1α), and Activating transcription factor-6α (ATF6α) were activated during Chlamydia infection...
December 8, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27913777/risk-factors-for-major-bleeding-in-the-seattle-ii-trial
#8
Immad Sadiq, Samuel Z Goldhaber, Ping-Yu Liu, Gregory Piazza
Ultrasound-facilitated, catheter-directed, low-dose fibrinolysis minimizes the risk of intracranial bleeding compared with systemic full-dose fibrinolytic therapy for pulmonary embolism (PE). However, major bleeding is nevertheless a potential complication. We analyzed the 150-patient SEATTLE II trial of submassive and massive PE patients to describe those who suffered major bleeding events following ultrasound-facilitated, catheter-directed, low-dose fibrinolysis and to identify risk factors for bleeding. Major bleeding was defined as GUSTO severe/life-threatening or moderate bleeds within 72 hours of initiation of the procedure...
February 2017: Vascular Medicine
https://www.readbyqxmd.com/read/27867284/ekosonic-thrombolysis-as-a-therapeutic-adjunct-in-venous-occlusive-disease
#9
D S Zaghlool, R W Franz, J Jenkins
The use of ultrasound waves in conjunction with local thrombolysis may accelerate clot resolution and serve as an important therapeutic adjunct in the treatment of venous occlusive disease. Our goal was to provide a larger sample population over a 5-year period to evaluate our experience with the EkoSonic endovascular system (EKOS, EKOS Corporation, Bothell, WA). We suspected that ultrasound-accelerated thrombolysis (UAT) using EKOS would provide excellent thrombolysis and midterm patency rates with minimal thrombolytic complications...
December 2016: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/27855736/glutamate-is-a-wake-active-neurotransmitter-in-drosophila-melanogaster
#10
John E Zimmerman, May T Chan, Olivia T Lenz, Brendan T Keenan, Greg Maislin, Allan I Pack
STUDY OBJECTIVES: In mammals, there is evidence that glutamate has a role as a wake active neurotransmitter. So using video-based analysis of Drosophila behavior we undertook a study to examine if glutamate, which has been previously shown to have an excitatory role in neuromuscular junctions in Drosophila, may have a conserved wake-active role in the adult brain. METHODS: Using 6-9 day old female flies we examined the effect of perturbations of the glutamatergic signaling on total wakefulness and wake bout architecture...
October 28, 2016: Sleep
https://www.readbyqxmd.com/read/27814388/new-vertical-handover-method-to-optimize-utilization-of-wireless-local-area-network-in-high-speed-environment
#11
Hoe Tung Yew, Eko Supriyanto, Muhammad Haikal Satria, Yuan Wen Hau
In heterogeneous wireless networks, wireless local area network (WLAN) is highly preferred by mobile terminals (MTs) owing to its high transmission bandwidth and low access cost. However, in high-speed environment, handover from a cellular network to a WLAN cell will lead to a high number of handover failures and unnecessary handovers due to the WLAN coverage limitation and will become worse at high speed. A new vertical handover method is proposed to minimize the probability of handover failure and unnecessary handover while maximizing the usage of WLAN in high-speed environment...
2016: PloS One
https://www.readbyqxmd.com/read/27807348/mtorc1-and-mtorc2-regulate-skin-morphogenesis-and-epidermal-barrier-formation
#12
Xiaolei Ding, Wilhelm Bloch, Sandra Iden, Markus A Rüegg, Michael N Hall, Maria Leptin, Linda Partridge, Sabine A Eming
Mammalian target of rapamycin (mTOR), a regulator of growth in many tissues, mediates its activity through two multiprotein complexes, mTORC1 or mTORC2. The role of mTOR signalling in skin morphogenesis and epidermal development is unknown. Here we identify mTOR as an essential regulator in skin morphogenesis by epidermis-specific deletion of Mtor in mice (mTOR(EKO)). mTOR(EKO) mutants are viable, but die shortly after birth due to deficits primarily during the early epidermal differentiation programme and lack of a protective barrier development...
October 27, 2016: Nature Communications
https://www.readbyqxmd.com/read/27800104/epidemiological-and-clinical-aspects-of-ear-nose-and-throat-sensorineural-emergencies-in-the-yaound%C3%A3-reference-hospital
#13
François Djomou, Yves Christian Andjock Nkouo, Eko David Mindja, Choffor Nchinda, Luc Meka, Emilia Mbamyah-Lyonga, Alexis Ndjolo
INTRODUCTION: Sensorineural emergencies (SNE) are rare clinical situations. Few patients consult early explaining subsequent difficulty in having accurate data and management. Three clinical conditions are considered SNE in otolaryngology; they include sudden sensorineural hearing loss (SSHL), Bell's palsy and acute vertigo. There is very little data available on sensorineural emergencies in our setting. The aim of this study was to provide preliminary data on the management of Ear Nose and Throat (ENT) sensorineural emergency cases in Yaoundé Reference Hospital...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27727246/data-from-a-pre-publication-independent-replication-initiative-examining-ten-moral-judgement-effects
#14
MULTICENTER STUDY
Warren Tierney, Martin Schweinsberg, Jennifer Jordan, Deanna M Kennedy, Israr Qureshi, S Amy Sommer, Nico Thornley, Nikhil Madan, Michelangelo Vianello, Eli Awtrey, Luke Lei Zhu, Daniel Diermeier, Justin E Heinze, Malavika Srinivasan, David Tannenbaum, Eliza Bivolaru, Jason Dana, Clintin P Davis-Stober, Christilene du Plessis, Quentin F Gronau, Andrew C Hafenbrack, Eko Yi Liao, Alexander Ly, Maarten Marsman, Toshio Murase, Michael Schaerer, Christina M Tworek, Eric-Jan Wagenmakers, Lynn Wong, Tabitha Anderson, Christopher W Bauman, Wendy L Bedwell, Victoria Brescoll, Andrew Canavan, Jesse J Chandler, Erik Cheries, Sapna Cheryan, Felix Cheung, Andrei Cimpian, Mark A Clark, Diana Cordon, Fiery Cushman, Peter H Ditto, Alice Amell, Sarah E Frick, Monica Gamez-Djokic, Rebecca Hofstein Grady, Jesse Graham, Jun Gu, Adam Hahn, Brittany E Hanson, Nicole J Hartwich, Kristie Hein, Yoel Inbar, Lily Jiang, Tehlyr Kellogg, Nicole Legate, Timo P Luoma, Heidi Maibeucher, Peter Meindl, Jennifer Miles, Alexandra Mislin, Daniel C Molden, Matt Motyl, George Newman, Hoai Huong Ngo, Harvey Packham, P Scott Ramsay, Jennifer L Ray, Aaron M Sackett, Anne-Laure Sellier, Tatiana Sokolova, Walter Sowden, Daniel Storage, Xiaomin Sun, Jay J Van Bavel, Anthony N Washburn, Cong Wei, Erik Wetter, Carlos T Wilson, Sophie-Charlotte Darroux, Eric Luis Uhlmann
We present the data from a crowdsourced project seeking to replicate findings in independent laboratories before (rather than after) they are published. In this Pre-Publication Independent Replication (PPIR) initiative, 25 research groups attempted to replicate 10 moral judgment effects from a single laboratory's research pipeline of unpublished findings. The 10 effects were investigated using online/lab surveys containing psychological manipulations (vignettes) followed by questionnaires. Results revealed a mix of reliable, unreliable, and culturally moderated findings...
October 11, 2016: Scientific Data
https://www.readbyqxmd.com/read/27666802/initial-experiences-with-endovascular-management-of-submassive-pulmonary-embolism-is-it-safe
#15
Timothy J Fuller, Christopher M Paprzycki, Muhammad H Zubair, Lala R Hussain, Brian A Kuhn, Matthew H Recht, Patrick E Muck
BACKGROUND: Interventional strategies for massive and submassive pulmonary embolism (smPE) have historically included either systematic intravenous thrombolytic alteplase or surgical embolectomy, both of which are associated with significant morbidity and mortality. However, with the advent of endovascular techniques, recent studies have suggested that an endovascular approach to the treatment of acute smPE may be both safe and effective with excellent outcomes. The purpose of this study was to evaluate the outcomes of patients who have undergone catheter-directed thrombolysis (CDT) for smPE at our institution in an effort to determine the safety of the procedure...
January 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27612515/enhanced-expansion-and-sustained-inductive-function-of-skin-derived-precursor-cells-in-computer-controlled-stirred-suspension-bioreactors
#16
Natacha A Agabalyan, Breanna S Borys, Holly D Sparks, Kathryn Boon, Eko W Raharjo, Sepideh Abbasi, Michael S Kallos, Jeff Biernaskie
: : Endogenous dermal stem cells (DSCs) reside in the adult hair follicle mesenchyme and can be isolated and grown in vitro as self-renewing colonies called skin-derived precursors (SKPs). Following transplantation into skin, SKPs can generate new dermis and reconstitute the dermal papilla and connective tissue sheath, suggesting they could have important therapeutic value for the treatment of skin disease (alopecia) or injury. Controlled cell culture processes must be developed to efficiently and safely generate sufficient stem cell numbers for clinical use...
September 9, 2016: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/27603199/pharmacomechanical-thrombectomy-of-upper-extremity-deep-vein-thrombosis
#17
Evren Ozcinar, Nur Dikmen Yaman, Mehmet Cakici, Cagdas Baran, Mustafa B Inan, Serkan Durdu, Ahmet R Akar, Mustafa Sirlak
BACKGROUND: This study aims to evaluate the efficacy and safety of ultrasound-accelerated catheter-directed thrombolysis (UACDT) in the treatment of upper extremity deep vein thrombosis (UEDVT). METHODS: We conducted a prospective, observational cohort study of consecutive patients with acute UEDVT with low-dose UACDT using the Ekosonic® Endovascular System, EKOS Corporation, Bothell, WA, USA at a single center from September 2012 until October 2014. Overall, sixteen patients(11 males and 6 females, age range 18 to 70 years, mean age, 45...
September 7, 2016: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/27546200/improved-method-to-track-and-precisely-count-schwann-cells-post-transplantation-in-a-peripheral-nerve-injury-model
#18
Hardeep S Gambhir, Eko Raharjo, Joanne Forden, Ranjan Kumar, Chinmaya Mishra, Gui Fang Guo, Joey Grochmal, Yuval Shapira, Rajiv Midha
BACKGROUND: To optimize survival evaluation of Schwann cells (SCs) in vivo, we tested fluorescent labeling of the nucleus as an improved method of tracking and counting the transplanted SCs at sciatic nerve injury sites in rodents. We also investigated if co-administering cells with the glial growth factor Neuregulin-1 β (NRG1β) improves in vivo survival. New Method We transduced SCs using a Lentiviral vector with a nuclear localization signal (NLS) fused with mCherry and transplanted them in the sciatic nerve of rat post-crush injury (bilateral) either in the presence or absence of NRG1β in the injectate media...
August 18, 2016: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/27510846/fast-targeting-and-cancer-cell-uptake-of-luminescent-antibody-nanozeolite-bioconjugates
#19
Riccardo Marega, Eko Adi Prasetyanto, Carine Michiels, Luisa De Cola, Davide Bonifazi
Understanding the targeted cellular uptake of nanomaterials is an essential step to engineer and program functional and effective biomedical devices. In this respect, the targeting and ultrafast uptake of zeolite nanocrystals functionalized with Cetuximab antibodies (Ctxb) by cells overexpressing the epidermal growth factor receptor are described here. Biochemical assays show that the cellular uptake of the bioconjugate in the targeted cancer cells already begins 15 min after incubation, at a rate around tenfold faster than that observed in the negative control cells...
October 2016: Small
https://www.readbyqxmd.com/read/27464843/epidermal-mineralocorticoid-receptor-plays-beneficial-and-adverse-effects-in-skin-and-mediates-glucocorticoid-responses
#20
Julia Boix, Lisa M Sevilla, Zara Sáez, Elena Carceller, Paloma Pérez
Glucocorticoids (GCs) regulate skin homeostasis and combat cutaneous inflammatory diseases; however, adverse effects of chronic GC treatments limit their therapeutic use. GCs bind and activate the GC receptor and the mineralocorticoid receptor (MR), transcription factors that recognize identical hormone responsive elements. Whether epidermal MR mediates beneficial or deleterious GC effects is of great interest for improving GC-based skin therapies. MR epidermal knockout mice exhibited increased keratinocyte proliferation and differentiation and showed resistance to GC-induced epidermal thinning...
July 25, 2016: Journal of Investigative Dermatology
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