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Jeon-Hor Chen, Siwa Chan, Nan-Han Lu, Yifan Li, Yu Chieh Tsai, Po Yun Huang, Chia-Ju Chang, Min-Ying Su
RATIONALE AND OBJECTIVES: Low-dose chest computed tomography (LDCT), increasingly being used for screening of lung cancer, may also be used to measure breast density, which is proven as a risk factor for breast cancer. In this study, we developed a segmentation method to measure quantitative breast density on CT images and correlated with magnetic resonance density. MATERIALS AND METHODS: Forty healthy women receiving both LDCT and breast magnetic resonance imaging (MRI) were studied...
September 2016: Academic Radiology
Janet M T Van Uem, Stefan Walgaard, Erik Ainsworth, Sandra E Hasmann, Tanja Heger, Susanne Nussbaum, Markus A Hobert, Encarnación M Micó-Amigo, Rob C Van Lummel, Daniela Berg, Walter Maetzler
INTRODUCTION: The instrumented-Timed-Up-and-Go test (iTUG) provides detailed information about the following movement patterns: sit-to-walk (siwa), straight walking, turning and walk-to-sit (wasi). We were interested in the relative contributions of respective iTUG sub-phases to specific clinical deficits most relevant for daily life in Parkinson's disease (PD). More specifically, we investigated which condition-fast speed (FS) or convenient speed (CS)-differentiates best between mild- to moderate-stage PD patients and controls, which parameters of the iTUG sub-phases are significantly different between PD patients and controls, and how the iTUG parameters associate with cognitive parameters (with particular focus on cognitive flexibility and working memory) and Health-Related-Quality of Life (HRQoL)...
2016: PloS One
Siwas Phungsripheng, Kazuyuki Kozawa, Munetaka Akita, Akiko Inagaki
Trinuclear Ru cluster photocatalysts that contain two Ru(II) photosensitizers and a Ru(II) reaction center are prepared, and their activity in the photocatalytic oxygenation of a sufide and alkenes is investigated. Photoirradiation (visible light) and the use of a Co salt ([Co(NH3)5Cl]Cl2, as an electron acceptor) are found to be essential for these catalytic reactions. The O atom of the water solvent (pH 6.8) is transferred to the substrate by a stepwise electron transfer and deprotonation of an aqua ligand at the reaction center...
April 18, 2016: Inorganic Chemistry
Weifeng Wang, Nigel T Roulet, Ian B Strachan, Alain Tremblay
The thermal dynamics of human created northern reservoirs (e.g., water temperatures and ice cover dynamics) influence carbon processing and air-water gas exchange. Here, we developed a process-based one-dimensional model (Snow, Ice, WAater, and Sediment: SIWAS) to simulate a full year's surface energy fluxes and thermal dynamics for a moderately large (>500km(2)) boreal hydroelectric reservoir in northern Quebec, Canada. There is a lack of climate and weather data for most of the Canadian boreal so we designed SIWAS with a minimum of inputs and with a daily time step...
April 15, 2016: Science of the Total Environment
Pacinte Moez, Doreen Nazeih Assaad Younan
BACKGROUND: Sickle cell haemoglobinopathy, the most frequent of the hereditary anomalies of haemoglobin, occurs most commonly in individuals of African descent. With a population of about 23 000, Siwa Oasis is situated in the Western Desert of Egypt, close to the Libyan border. It is Egypt's most remote oasis town and the Siwans have developed their own distinct Berber culture. Siwans represent a closed isolated community suffering from various health problems, among which is haemolytic anaemia...
July 2016: Journal of Clinical Pathology
Peter T Fwu, Jeon-Hor Chen, Yifan Li, Siwa Chan, Min-Ying Su
PURPOSE: This study presented a three-dimensional magnetic resonance (MR)-based method to separate a breast into four quadrants for quantitative measurements of the quadrant breast volume (BV) and density. METHODS: Breast MR images from 58 healthy women were studied. The breast and the fibroglandular tissue were segmented by using a computer-based algorithm. A breast was divided into four quadrants using two perpendicular planes intersecting at the nipple or the nipple-centroid line...
August 2015: Translational Oncology
Jeon-Hor Chen, Siwa Chan, Yi-Ting Tang, Jia Shen Hon, Po-Chuan Tseng, Angela T Cheriyan, Nikita Rakesh Shah, Dah-Cherng Yeh, San-Kan Lee, Wen-Pin Chen, Christine E McLaren, Min-Ying Su
PURPOSE: This study investigated the impact of arms/hands and body position on the measurement of breast density using MRI. METHODS: Noncontrast-enhanced T1-weighted images were acquired from 32 healthy women. Each subject received four MR scans using different experimental settings, including a high resolution hands-up, a low resolution hands-up, a high resolution hands-down, and finally, another high resolution hands-up after repositioning. The breast segmentation was performed using a fully automatic chest template-based method...
May 2015: Medical Physics
Ana Guinote, Ioanna Cotzia, Sanpreet Sandhu, Pramila Siwa
Humans are a cooperative species, capable of altruism and the creation of shared norms that ensure fairness in society. However, individuals with different educational, cultural, economic, or ethnic backgrounds differ in their levels of social investment and endorsement of egalitarian values. We present four experiments showing that subtle cues to social status (i.e., prestige and reputation in the eyes of others) modulate prosocial orientation. The experiments found that individuals who experienced low status showed more communal and prosocial behavior, and endorsed more egalitarian life goals and values compared with those who experienced high status...
January 20, 2015: Proceedings of the National Academy of Sciences of the United States of America
Han Gao, Keryn Lian
The effects of nano-SiO2 and nano-TiO2 fillers on a thin film silicotungstic acid (SiWA)-H3PO4-poly(vinyl alcohol) (PVA) proton conducting polymer electrolyte were studied and compared with respect to their proton conductivity, environmental stability, and dielectric properties, across a temperature range from 243 to 323 K. Three major effects of these fillers have been identified: (a) barrier effect; (b) intrinsic dielectric constant effect; and (c) water retention effect. Dielectric analyses were used to differentiate these effects on polymer electrolyte-enabled capacitors...
January 8, 2014: ACS Applied Materials & Interfaces
Muqing Lin, Jeon-Hor Chen, Xiaoyong Wang, Siwa Chan, Siping Chen, Min-Ying Su
PURPOSE: Methods for quantification of breast density on MRI using semiautomatic approaches are commonly used. In this study, the authors report on a fully automatic chest template-based method. METHODS: Nonfat-suppressed breast MR images from 31 healthy women were analyzed. Among them, one case was randomly selected and used as the template, and the remaining 30 cases were used for testing. Unlike most model-based breast segmentation methods that use the breast region as the template, the chest body region on a middle slice was used as the template...
December 2013: Medical Physics
Abir Ben Halima, Raoudha Bahri, Esther Esteban, Mohamed Habib Ben Aribia, Pedro Moral, Hassen Chaabani
BACKGROUND: It is thought that the ancient population of Libya was mainly composed of Saharan Berbers. Socio-geographic conditions and historical events have exerted some changes on the composition of the present-day Libyan population. AIM: To screen a set of autosomal Alu markers in a representative sample of the general Libyan population in order to study its ethnic and genetic structure and to re-examine its genetic relationships with Mediterranean and Middle Eastern groups...
May 2014: Annals of Human Biology
Jeon-Hor Chen, Siwa Chan, Dah-Cherng Yeh, Peter T Fwu, Muqing Lin, Min-Ying Su
The normal breast tissue responds to the fluctuation of endogenous hormones during a menstrual cycle (MC) and shows changes in breast density. The changes between left and right breasts of the same women were compared to evaluate the symmetrical response. Twenty-four healthy women were recruited in this study. Four weekly magnetic resonance imaging (MRI) studies were performed during one MC. A computer algorithm was used to segment the breast and the fibroglandular tissue to measure the fibroglandular tissue volume (FV) and three morphological parameters: circularity, convexity and irregularity...
May 2013: Magnetic Resonance Imaging
Jeon-Hor Chen, Siwa Chan, Yi-Jui Liu, Dah-Cherng Yeh, Chih-Kai Chang, Li-Kuang Chen, Wei-Fan Pan, Chih-Chen Kuo, Muqing Lin, Daniel H E Chang, Peter T Fwu, Min-Ying Su
PURPOSE: To compare the breast volume (BV), fibroglandular tissue volume (FV), and percent density (PD) measured from breast MRI of the same women using four different MR scanners. METHODS: The study was performed in 34 healthy Asian volunteers using two 1.5T (GE and Siemens) and two 3T (GE and Philips) MR scanners. The BV, FV, and PD were measured on nonfat-suppressed T1-weighted images using a comprehensive computer algorithm-based segmentation method. The scanner-to-scanner measurement difference, and the coefficient of variation (CV) among the four scanners were calculated...
August 2012: Medical Physics
Siwa Chan, Min-Ying L Su, Fu-Ju Lei, Jia-Pei Wu, Muqing Lin, Orhan Nalcioglu, Stephen A Feig, Jeon-Hor Chen
PURPOSE: To investigate the fluctuation of fibroglandular tissue volume (FV) and percentage of breast density (PD) during the menstrual cycle and compare with postmenopausal women by using three-dimensional magnetic resonance (MR)-based segmentation methods. MATERIALS AND METHODS: This study was approved by the Institutional Review Board and was HIPAA compliant. Written informed consent was obtained. Thirty healthy female subjects, 24 premenopausal and six postmenopausal, were recruited...
December 2011: Radiology
Muqing Lin, Jeon-Hor Chen, Rita S Mehta, Shadfar Bahri, Siwa Chan, Orhan Nalcioglu, Min-Ying Su
Breast MRI acquires many images from the breast, and computer-aided algorithms and display tools are often used to assist the radiologist's interpretation. Women with lifetime risk greater than 20% of developing breast cancer are recommended to receive annual screening MRI, but the current breast MRI computer-aided-diagnosis systems do not provide the necessary function for comparison of images acquired at different times. The purpose of this work was to develop registration methods for evaluating the spatial change pattern of fibroglandular tissue between two breast MRI scans of the same woman taken at different times...
September 21, 2011: Physics in Medicine and Biology
Muqing Lin, Siwa Chan, Jeon-Hor Chen, Daniel Chang, Ke Nie, Shih-Ting Chen, Cheng-Ju Lin, Tzu-Ching Shih, Orhan Nalcioglu, Min-Ying Su
PURPOSE: Quantitative breast density is known as a strong risk factor associated with the development of breast cancer. Measurement of breast density based on three-dimensional breast MRI may provide very useful information. One important step for quantitative analysis of breast density on MRI is the correction of field inhomogeneity to allow an accurate segmentation of the fibroglandular tissue (dense tissue). A new bias field correction method by combining the nonparametric nonuniformity normalization (N3) algorithm and fuzzy-C-means (FCM)-based inhomogeneity correction algorithm is developed in this work...
January 2011: Medical Physics
Hesham M El-Naggar
BACKGROUND: The main activity in Siwa Oasis society is the agriculture, it depends on the groundwater. The agricultural drainage water and the unused saline water of naturally flowing springs are poured into four main salty lakes. This leads to an increase in the surface area of the saltwater lakes, marshes and rise in water table levels. AIM: to investigate some environmental engineering interventions to control the expansion of saltwater surface area in Siwa Oasis...
2010: Journal of the Egyptian Public Health Association
Hesham M El-Naggar
BACKGROUND: Ground water is the only water resource for Siwa Oasis. It is obtained from natural freshwater wells and springs fed by the Nubian aquifer. Water samples collected from Siwa Oasis had relatively higher iron (Fe) and manganese (Mn) than the permissible limits specified in WHO Guidelines and Egyptian Standards for drinking water quality. Aeration followed by sand filtration is the most commonly used method for the removal of iron from ground water. AIM: The study aimed at development of low-cost technology for the removal of iron and manganese from ground water in Siwa Oasis...
2010: Journal of the Egyptian Public Health Association
Siwa Chan, Jeon-Hor Chen, Garima Agrawal, Muqing Lin, Rita S Mehta, Philip M Carpenter, Orhan Nalcioglu, Min-Ying Su
To characterize imaging features of pure DCIS on dynamic contrast-enhanced MR imaging (DCE-MRI), 31 consecutive patients (37-81 years old, mean 56), including 2 Grade I, 16 Grade II, and 13 Grade III, were studied. MR images were reviewed retrospectively and the morphological appearances and kinetic features of breast lesions were categorized according to the ACR BI-RADS breast MRI lexicon. DCE-MRI was a sensitive imaging modality in detecting pure DCIS. MR imaging showed enhancing lesions in 29/31 (94%) cases...
2010: Journal of Oncology
Ke Nie, Min-Ying Su, Man-Kwun Chau, Siwa Chan, Hoanglong Nguyen, Tiffany Tseng, Yuhong Huang, Christine E McLaren, Orhan Nalcioglu, Jeon-Hor Chen
PURPOSE: The purpose of this study was to evaluate the age- and race-dependence of the breast fibroglandular tissue density based on three-dimensional breast MRI. METHODS: The normal breasts of 321 consecutive patients including Caucasians, Asians, and Hispanics were studied. The subjects were separated into three age groups: Younger than 45, between 45 and 55, and older than 55. Computer algorithms based on body landmarks were used to segment the breast, and fuzzy c-means algorithm was used to segment the fibroglandular tissue...
June 2010: Medical Physics
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