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https://www.readbyqxmd.com/read/28332351/metabolism-centric-overview-of-the-pathogenesis-of-alzheimer-s-disease
#1
REVIEW
Somang Kang, Yong Ho Lee, Jong Eun Lee
Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia. AD is characterized by the extracellular amyloid beta (Aβ) plaques and intraneuronal deposits of neurofibrillary tangles (NFTs). Recently, as aging has become a familiar phenomenon around the world, patients with AD are increasing in number. Thus, many researchers are working toward finding effective therapeutics for AD focused on Aβ hypothesis, although there has been no success yet. In this review paper, we suggest that AD is a metabolic disease and that we should focus on metabolites that are affected by metabolic alterations to find effective therapeutics for AD...
May 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28323825/association-between-fatty-acid-metabolism-in-the-brain-and-alzheimer-disease-neuropathology-and-cognitive-performance-a-nontargeted-metabolomic-study
#2
Stuart G Snowden, Amera A Ebshiana, Abdul Hye, Yang An, Olga Pletnikova, Richard O'Brien, John Troncoso, Cristina Legido-Quigley, Madhav Thambisetty
BACKGROUND: The metabolic basis of Alzheimer disease (AD) pathology and expression of AD symptoms is poorly understood. Omega-3 and -6 fatty acids have previously been linked to both protective and pathogenic effects in AD. However, to date little is known about how the abundance of these species is affected by differing levels of disease pathology in the brain. METHODS AND FINDINGS: We performed metabolic profiling on brain tissue samples from 43 individuals ranging in age from 57 to 95 y old who were stratified into three groups: AD (N = 14), controls (N = 14) and "asymptomatic Alzheimer's disease" (ASYMAD), i...
March 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28317643/biomarkers-for-the-diagnosis-of-alzheimer-s-disease-in-clinical-practice-an-italian-intersocietal-roadmap
#3
Giovanni B Frisoni, Daniela Perani, Stefano Bastianello, Gaetano Bernardi, Corinna Porteri, Marina Boccardi, Stefano F Cappa, Marco Trabucchi, Alessandro Padovani
Biomarkers of brain amyloidosis and neurodegeneration/synaptic dysfunction are featured in recent diagnostic criteria for Alzheimer's disease. Several gaps in our knowledge, however, need to be filled before they can be adopted clinically. The aim of this article is to describe a roadmap, developed by a multidisciplinary task force, to rationally implement biomarkers for Italian Memory Clinics. This roadmap is based on a framework comprising 5 sequential phases: identification of leads for potentially useful biomarkers; development of clinical assays for clinical disease; evaluation of detection of early stages; definition of operating characteristics in relevant populations; and estimation of reducing disease-associated mortality, morbidity, and disability...
April 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28316569/longitudinal-analysis-for-disease-progression-via-simultaneous-multi-relational-temporal-fused-learning
#4
Baiying Lei, Feng Jiang, Siping Chen, Dong Ni, Tianfu Wang
It is highly desirable to predict the progression of Alzheimer's disease (AD) of patients [e.g., to predict conversion of mild cognitive impairment (MCI) to AD], especially longitudinal prediction of AD is important for its early diagnosis. Currently, most existing methods predict different clinical scores using different models, or separately predict multiple scores at different future time points. Such approaches prevent coordinated learning of multiple predictions that can be used to jointly predict clinical scores at multiple future time points...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28304294/long-term-cognitive-decline-in-dementia-with-lewy-bodies-in-a-large-multicenter-international-cohort
#5
Milica G Kramberger, Bjørn Auestad, Sara Garcia-Ptacek, Carla Abdelnour, Josep Garre Olmo, Zuzana Walker, Afina W Lemstra, Elisabet Londos, Frederic Blanc, Laura Bonanni, Ian McKeith, Bengt Winblad, Frank Jan de Jong, Flavio Nobili, Elka Stefanova, Maria Petrova, Cristian Falup-Pecurariu, Irena Rektorova, Sevasti Bostantjopoulou, Roberta Biundo, Daniel Weintraub, Dag Aarsland
BACKGROUND/OBJECTIVE: The aim of this study was to describe the rate and clinical predictors of cognitive decline in dementia with Lewy bodies (DLB), and compare the findings with Alzheimer's disease (AD) and Parkinson's disease dementia (PDD) patients. METHODS: Longitudinal scores for the Mini-Mental State Examination (MMSE) in 1,290 patients (835 DLB, 198 PDD, and 257 AD) were available from 18 centers with up to three years longitudinal data. Linear mixed effects analyses with appropriate covariates were used to model MMSE decline over time...
March 10, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28293162/ensemble-classification-of-alzheimer-s-disease-and-mild-cognitive-impairment-based-on-complex-graph-measures-from-diffusion-tensor-images
#6
Ashkan Ebadi, Josué L Dalboni da Rocha, Dushyanth B Nagaraju, Fernanda Tovar-Moll, Ivanei Bramati, Gabriel Coutinho, Ranganatha Sitaram, Parisa Rashidi
The human brain is a complex network of interacting regions. The gray matter regions of brain are interconnected by white matter tracts, together forming one integrative complex network. In this article, we report our investigation about the potential of applying brain connectivity patterns as an aid in diagnosing Alzheimer's disease and Mild Cognitive Impairment (MCI). We performed pattern analysis of graph theoretical measures derived from Diffusion Tensor Imaging (DTI) data representing structural brain networks of 45 subjects, consisting of 15 patients of Alzheimer's disease (AD), 15 patients of MCI, and 15 healthy subjects (CT)...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28291839/microstructural-white-matter-alterations-in-preclinical-alzheimer-s-disease-detected-using-free-water-elimination-diffusion-tensor-imaging
#7
Andrew R Hoy, Martina Ly, Cynthia M Carlsson, Ozioma C Okonkwo, Henrik Zetterberg, Kaj Blennow, Mark A Sager, Sanjay Asthana, Sterling C Johnson, Andrew L Alexander, Barbara B Bendlin
Brain changes associated with Alzheimer's disease (AD) begin decades before disease diagnosis. While β-amyloid plaques and neurofibrillary tangles are defining features of AD, neuronal loss and synaptic pathology are closely related to the cognitive dysfunction. Brain imaging methods that are tuned to assess degeneration of myelinated nerve fibers in the brain (collectively called white matter) include diffusion tensor imaging (DTI) and related techniques, and are expected to shed light on disease-related loss of structural connectivity...
2017: PloS One
https://www.readbyqxmd.com/read/28290244/kinematic-and-pressure-features-of-handwriting-and-drawing-preliminary-results-between-patients-with-mild-cognitive-impairment-alzheimer-disease-and-healthy-controls
#8
Josep Garre-Olmo, Marcos Faúndez-Zanuy, Karmele López-de-Ipiña, Laia Calvó-Perxas, Oriol Turró-Garriga
BACKGROUND: Alzheimer's disease (AD) is the most common neurodegenerative dementia of old age, and the leading chronic disease contributor to disability and dependence among older people worldwide. Clinically, AD is characterized by a progressive cognitive decline that interferes with the ability to perform the activities of daily living. Handwriting and drawing are complex human activities that entail an intricate blend of cognitive, kinesthetic, and perceptual-motor features. OBJECTIVE: To compare the kinematic characteristics of handwriting and drawing between patients with AD, patients with mild cognitive impairment (MCI) and healthy controls...
March 9, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28289920/the-early-presentation-of-dementia-in-people-with-down-syndrome-a-systematic-review-of-longitudinal-studies
#9
REVIEW
Bianca Alexandra Lautarescu, Anthony John Holland, Shahid H Zaman
Adults with Down syndrome (DS) are at a very high risk of developing early onset Alzheimer's disease (AD) due to trisomy of chromosome 21. AD is preceded by a prolonged prodromal "pre-clinical" phase presenting with clinical features that do not fulfil the diagnostic criteria for AD. It is important to clinically characterise this prodromal stage to help early detection of the disease as neuropathology of AD is almost universal by the fifth decade in DS. There is a lack of knowledge of the trajectory of decline associated with the onset of dementia in this population and early signs may be overlooked or misdiagnosed, negatively affecting the quality of life of those affected and the use of early pharmacological or psychosocial interventions...
March 13, 2017: Neuropsychology Review
https://www.readbyqxmd.com/read/28285126/expression-of-neprilysin-in-periodontitis-affected-gingival-tissues
#10
A Nezu, T Kubota, S Maruyama, M Nagata, K Nohno, T Morozumi, H Yoshie
OBJECTIVE: Although the pathogeneses of Alzheimer's disease (AD) and periodontal diseases have overlapping features, including ageing and chronic inflammation, the association between AD and periodontitis remains unclear. To explore the pathogenesis of periodontitis, a comprehensive gene expression/transcriptome analysis in periodontitis-affected gingival tissues found that the AD pathway was significantly up-regulated in periodontitis-affected gingival tissues. AD-related genes, amyloid beta precursor protein (APP), interleukin-1 beta and compliment 1QA, were significantly elevated in periodontitis...
March 6, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28284228/interactive-wearable-systems-for-upper-body-rehabilitation-a-systematic-review
#11
REVIEW
Qi Wang, Panos Markopoulos, Bin Yu, Wei Chen, Annick Timmermans
BACKGROUND: The development of interactive rehabilitation technologies which rely on wearable-sensing for upper body rehabilitation is attracting increasing research interest. This paper reviews related research with the aim: 1) To inventory and classify interactive wearable systems for movement and posture monitoring during upper body rehabilitation, regarding the sensing technology, system measurements and feedback conditions; 2) To gauge the wearability of the wearable systems; 3) To inventory the availability of clinical evidence supporting the effectiveness of related technologies...
March 11, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/28269773/impact-of-recruitment-methods-in-subjective-cognitive-decline
#12
Carla Abdelnour Ruiz, Octavio Rodríguez-Gómez, Montserrat Alegre, Sergi Valero, Sonia Moreno-Grau, Sanabria Ángela, Isabel Hernández, Maitée Rosende-Roca, Liliana Vargas, Anna Mauleón, Domingo Sánchez, Ana Espinosa, Gemma Ortega, Alba Pérez-Cordón, Susana Diego, Anna Gailhajanet, Marina Guitart, Óscar Sotolongo-Grau, Agustí Ruiza, Lluís Tárraga, Mercè Boada
BACKGROUND: Recruitment methods can determine sample characteristics in mild cognitive impairment and Alzheimer's disease dementia, but little is known about its influence in subjective cognitive decline (SCD). OBJECTIVE: To determine the influence of two types of recruitment methods in the characteristics of individuals with SCD. METHODS: We select and compare clinical and neuropsychological features, and frequency of APOE ɛ4 allele of 326 subjects with SCD from two cohorts: Open House Initiative (OHI) versus Memory Unit (MU)...
March 1, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28269766/methylene-blue-tetramethylthionine-chloride-influences-the-mobility-of-adult-neural-stem-cells-a-potentially-novel-therapeutic-mechanism-of-a-therapeutic-approach-in-the-treatment-of-alzheimer-s-disease
#13
Amelie van der Ven, Julius Pape, Dirk Hermann, Robert Schloesser, Just Genius, Nadine Fischer, Rainald Mößner Mössnerf, Norbert Scherbaum, Jens Wiltfang, Dan Rujescu, Jens Benninghoff
An interest in neurogenesis in the adult human brain as a relevant and targetable process has emerged as a potential treatment option for Alzheimer's disease and other neurodegenerative conditions. The aim of this study was to investigate the effects of tetramethylthionine chloride (methylene blue, MB) on properties of adult murine neural stem cells. Based on recent clinical studies, MB has increasingly been discussed as a potential treatment for Alzheimer's disease. While no differences in the proliferative capacity were identified, a general potential of MB in modulating the migratory capacity of adult neural stem cells was indicated in a cell mobility assay...
March 2, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28269248/assessing-app-quality-through-expert-peer-review-a-case-study-from-the-gray-matters-study
#14
Phillip J Hartin, Ian Cleland, Chris D Nugent, Sally I McClean, JoAnn Tschanz, Christine Clark, Maria C Norton
Health apps focused on inciting behavior change are becoming increasingly popular. Nevertheless, many lack underlying evidence base, scientific credibility and have limited clinical effectiveness. It is therefore important that apps are well-informed, scientifically credible, peer reviewed and evidence based. This paper presents the use of the Mobile App Rating Scale (MARS) to assess the quality of the Grey Matters app, a cross platform app to deliver health education material and track behavior change across multi-domains with the aim of reducing the risk of developing Alzheimer's disease...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268491/changes-in-the-eeg-amplitude-as-a-biomarker-for-early-detection-of-alzheimer-s-disease
#15
Ali H Al-Nuaimi, Emmanuel Jammeh, Lingfen Sun, Emmanuel Ifeachor
The rapid increase in the number of older people with Alzheimer's disease (AD) and other forms of dementia represents one of the major challenges to the health and social care systems. Early detection of AD makes it possible for patients to access appropriate services and to benefit from new treatments and therapies, as and when they become available. The onset of AD starts many years before the clinical symptoms become clear. A biomarker that can measure the brain changes in this period would be useful for early diagnosis of AD...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28260614/classification-of-alzheimer-s-disease-and-prediction-of-mild-cognitive-impairment-to-alzheimer-s-conversion-from-structural-magnetic-resource-imaging-using-feature-ranking-and-a-genetic-algorithm
#16
Iman Beheshti, Hasan Demirel, Hiroshi Matsuda
We developed a novel computer-aided diagnosis (CAD) system that uses feature-ranking and a genetic algorithm to analyze structural magnetic resonance imaging data; using this system, we can predict conversion of mild cognitive impairment (MCI)-to-Alzheimer's disease (AD) at between one and three years before clinical diagnosis. The CAD system was developed in four stages. First, we used a voxel-based morphometry technique to investigate global and local gray matter (GM) atrophy in an AD group compared with healthy controls (HCs)...
February 27, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28259709/consensus-classification-of-posterior-cortical-atrophy
#17
Sebastian J Crutch, Jonathan M Schott, Gil D Rabinovici, Melissa Murray, Julie S Snowden, Wiesje M van der Flier, Bradford C Dickerson, Rik Vandenberghe, Samrah Ahmed, Thomas H Bak, Bradley F Boeve, Christopher Butler, Stefano F Cappa, Mathieu Ceccaldi, Leonardo Cruz de Souza, Bruno Dubois, Olivier Felician, Douglas Galasko, Jonathan Graff-Radford, Neill R Graff-Radford, Patrick R Hof, Pierre Krolak-Salmon, Manja Lehmann, Eloi Magnin, Mario F Mendez, Peter J Nestor, Chiadi U Onyike, Victoria S Pelak, Yolande Pijnenburg, Silvia Primativo, Martin N Rossor, Natalie S Ryan, Philip Scheltens, Timothy J Shakespeare, Aida Suárez González, David F Tang-Wai, Keir X X Yong, Maria Carrillo, Nick C Fox
INTRODUCTION: A classification framework for posterior cortical atrophy (PCA) is proposed to improve the uniformity of definition of the syndrome in a variety of research settings. METHODS: Consensus statements about PCA were developed through a detailed literature review, the formation of an international multidisciplinary working party which convened on four occasions, and a Web-based quantitative survey regarding symptom frequency and the conceptualization of PCA...
March 1, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28258666/the-role-of-gene-editing-in-neurodegenerative-diseases
#18
Hueng-Chuen Fan, Ching-Shiang Chi, Yih-Jing Lee, Jeng-Dau Tsai, Shinn-Zong Lin, Horng-Jyh Harn
Neurodegenerative diseases (NDs), at least including Alzheimer's, Huntington's, and Parkinson's diseases, have become the most dreaded maladies because of no precise diagnostic tools or definite treatments for these debilitating diseases. The increased prevalence and a substantial impact on the social-economic and medical care of NDs propel governments to develop policies to counteract the impact. Although the etiologies of NDs are still unknown, growing evidence suggests that genetic, cellular and circuit alternations may cause the generation of abnormal misfolded proteins, which uncontrolledly accumulate to damage eventually overwhelms the protein-disposal mechanisms of these neurons, leading to a common pathological feature of NDs...
March 3, 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28255200/optimizing-neuropsychological-assessments-for-cognitive-behavioral-and-functional-impairment-classification-a-machine-learning-study
#19
Petronilla Battista, Christian Salvatore, Isabella Castiglioni
Subjects with Alzheimer's disease (AD) show loss of cognitive functions and change in behavioral and functional state affecting the quality of their daily life and that of their families and caregivers. A neuropsychological assessment plays a crucial role in detecting such changes from normal conditions. However, despite the existence of clinical measures that are used to classify and diagnose AD, a large amount of subjectivity continues to exist. Our aim was to assess the potential of machine learning in quantifying this process and optimizing or even reducing the amount of neuropsychological tests used to classify AD patients, also at an early stage of impairment...
2017: Behavioural Neurology
https://www.readbyqxmd.com/read/28243102/from-mild-cognitive-impairment-to-subjective-cognitive-decline-conceptual-and-methodological-evolution
#20
REVIEW
Yu-Wen Cheng, Ta-Fu Chen, Ming-Jang Chiu
Identification of subjects at the early stages of Alzheimer's disease (AD) is fundamental for drug development and possible intervention or prevention of cognitive decline. The concept of mild cognitive impairment (MCI) evolved during the past two decades to define subjects at the transitional stage between normal aging and dementia. Evidence from cross-sectional and longitudinal studies has shown that MCI is associated with an increased risk of positive AD biomarkers and an increased annual conversion rate of 5%-17% to AD...
2017: Neuropsychiatric Disease and Treatment
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