Mohamed A M El Gendy, Hamdy Hassanein, Fatma M Saleh, Feridoun Karimi-Busheri, Mesfin Fanta, Xiaoyan Yang, Doaa Tawfik, Shorouk Morsy, Merna Fahmy, Mahmoud Hemid, Mohamed Abdel Azeiz, Ahmed Fared, Michael Weinfeld
AIMS: the main purpose of this study was to identify new selective antitumor agents. MAIN METHODS: several hydrazonoyl chlorides (HCs) were synthesized and human tumor cell line viability was determined using the MTT assay. Tumor development was assessed using Ehrlich ascites carcinoma (EAC)-bearing mice. KEY FINDINGS: our results showed that 2-oxo-N-phenyl-2-(phenylamino)acetohydrazonoyl chloride (compound 4; CPD 4) and 2-oxo-2-(phenylamino)-N-(p-tolyl)acetohydrazonoyl chloride (CPD 5) were the most cytotoxic HCs to human cervical tumor HeLa (IC50 : 20 and 25 μM for CPD 4 and 5 respectively), breast MCF7 (IC50 : 29 and 34 μM for CPD 4 and 5 respectively) and colon HCT116 cancer cells (IC50 : 26 and 25 μM for CPD 4 and 5 respectively) with the least cytotoxicity to human non-tumor CCD-18Co colon fibroblasts as well as murine splenocytes...
April 15, 2022: Life Sciences