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https://www.readbyqxmd.com/read/28214234/reablement-reactivation-rehabilitation-and-restorative-interventions-with-older-adults-in-receipt-of-home-care-a-systematic-review
#1
REVIEW
Joanie Sims-Gould, Catherine E Tong, Lutetia Wallis-Mayer, Maureen C Ashe
OBJECTIVE: To systematically review the impact of reablement, reactivation, rehabilitation, and restorative (4R) programs for older adults in receipt of home care services. DESIGN: Systematic review. DATA SOURCES: We searched the following electronic bibliographic databases: MEDLINE, EMBASE, PsycINFO, CINAHL (Cumulative Index to Nursing and Allied Health), SPORTDiscus and The Cochrane Library and reference lists. STUDY SELECTION: Randomized controlled trials that describe original data on the impact of home-based rehabilitative care and were written in English...
February 14, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28212522/taking-up-the-cudgels-for-the-traditional-reactive-oxygen-and-nitrogen-species-detection-assays-and-their-use-in-the-cardiovascular-system
#2
REVIEW
Andreas Daiber, Matthias Oelze, Sebastian Steven, Swenja Kröller-Schön, Thomas Münzel
Reactive oxygen and nitrogen species (RONS such as H2O2, nitric oxide) confer redox regulation of essential cellular functions (e.g. differentiation, proliferation, migration, apoptosis), initiate and catalyze adaptive stress responses. In contrast, excessive formation of RONS caused by impaired break-down by cellular antioxidant systems and/or insufficient repair of the resulting oxidative damage of biomolecules may lead to appreciable impairment of cellular function and in the worst case to cell death, organ dysfunction and severe disease phenotypes of the entire organism...
February 7, 2017: Redox Biology
https://www.readbyqxmd.com/read/28212265/variations-in-oxidative-stress-levels-in-3-days-follow-up-in-ultramarathon-mountain-race-athletes
#3
Ypatios Spanidis, Dimitrios Stagos, Marina Orfanou, Nikolaos Goutzourelas, David Bar-Or, Demetrios Spandidos, Demetrios Kouretas
Spanidis, Y, Stagos, D, Orfanou, M, Goutzourelas, N, Bar-or, D, Spandidos, D, and Kouretas, D. Variations in oxidative stress levels in 3 days follow-up in ultramarathon mountain race athletes. J Strength Cond Res 31(3): 582-594, 2017-The aim of the present study was the monitoring of the redox status of runners participating in a mountain ultramarathon race of 103 km. Blood samples from 12 runners were collected prerace and 24, 48, and 72 hours postrace. The samples were analyzed by using conventional oxidative stress markers, such as protein carbonyls (CARB), thiobarbituric acid reactive substances (TBARS), total antioxidant capacity (TAC) in plasma, as well as glutathione (GSH) levels and catalase (CAT) activity in erythrocytes...
March 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28202646/mussel-adhesion-essential-footwork
#4
REVIEW
J Herbert Waite
Robust adhesion to wet, salt-encrusted, corroded and slimy surfaces has been an essential adaptation in the life histories of sessile marine organisms for hundreds of millions of years, but it remains a major impasse for technology. Mussel adhesion has served as one of many model systems providing a fundamental understanding of what is required for attachment to wet surfaces. Most polymer engineers have focused on the use of 3,4-dihydroxyphenyl-l-alanine (Dopa), a peculiar but abundant catecholic amino acid in mussel adhesive proteins...
February 15, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28196514/defining-the-contribution-of-neuroinflammation-to-parkinson-s-disease-in-humanized-immune-system-mice
#5
Gunjan Dhawan Manocha, Angela Marie Floden, Kendra Lynn Puig, Kumi Nagamoto-Combs, Clemens R Scherzer, Colin Kelly Combs
BACKGROUND: Reactive microglia have been associated with the histological changes that occur in Parkinson's disease brains and mouse models of the disease. Multiple studies from autopsy brains have verified the presence of microgliosis in several brain regions including substantia nigra, striatum, hippocampus and various cortical areas. MPTP injections in rodents have also shown striato-nigral microgliosis correlating with the loss of dopaminergic neurons. However, consistent data with respect to cytokine and immune cell changes during Parkinson's disease have not been fully defined...
February 14, 2017: Molecular Neurodegeneration
https://www.readbyqxmd.com/read/28194004/genetic-contributions-to-self-reported-tiredness
#6
V Deary, S P Hagenaars, S E Harris, W D Hill, G Davies, D C M Liewald, A M McIntosh, C R Gale, I J Deary
Self-reported tiredness and low energy, often called fatigue, are associated with poorer physical and mental health. Twin studies have indicated that this has a heritability between 6 and 50%. In the UK Biobank sample (N=108 976), we carried out a genome-wide association study (GWAS) of responses to the question, 'Over the last two weeks, how often have you felt tired or had little energy?' Univariate GCTA-GREML found that the proportion of variance explained by all common single-nucleotide polymorphisms for this tiredness question was 8...
February 14, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28187256/simulating-substrate-recognition-and-oxidation-in-laccases-from-description-to-design
#7
Maria Fatima Lucas, Emanuele Monza, Lise J Jørgensen, Heidi A Ernst, Klaus Piontek, Morten Jannik Bjerrum, Angel T Martínez, Susana Camarero, Victor Guallar
To meet the very specific requirements demanded by industry, proteins must be appropriately tailored. Engineering laccases, to improve the oxidation of small molecules, with applications in multiple fields, is however a difficult task. Most efforts have concentrated on increasing the redox potential of the enzyme but in recent work we have pursued an alternate strategy to engineering these biocatalysts. In particular, we have found that redesigning substrate binding at the T1 pocket, guided by in silico methodologies, to be a more consistent option...
February 10, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28186408/functional-microgels-and-microgel-systems
#8
Felix A Plamper, Walter Richtering
Microgels are macromolecular networks swollen by the solvent in which they are dissolved. They are unique systems that are distinctly different from common colloids, such as, e.g., rigid nanoparticles, flexible macromolecules, micelles, or vesicles. The size of the microgel networks is in the range of several micrometers down to nanometers (then sometimes called "nanogels"). In a collapsed state, they might resemble hard colloids but they can still contain significant amounts of solvent. When swollen, they are soft and have a fuzzy surface with dangling chains...
February 10, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28174526/reconsolidation-extinction-interactions-in-fear-memory-attenuation-the-role-of-inter-trial-interval-variability
#9
Allison Auchter, Lawrence K Cormack, Yael Niv, Francisco Gonzalez-Lima, Marie H Monfils
Fear extinction typically results in the formation of a new inhibitory memory that suppresses the original conditioned response. Evidence also suggests that extinction training during a retrieval-induced labile period results in integration of the extinction memory into the original fear memory, rendering the fear memory less susceptible to reinstatement. Here we investigated the parameters by which the retrieval-extinction paradigm was most effective in memory updating. Specifically, we manipulated the inter-trial intervals (ITIs) between conditional stimulus (CS) presentations during extinction, examining how having interval lengths with different degrees of variability affected the strength of memory updating...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28165280/maternal-executive-function-heart-rate-and-eeg-alpha-reactivity-interact-in-the-prediction-of-harsh-parenting
#10
Kirby Deater-Deckard, Martha Ann Bell
Do physiological and behavioral performance indicators of effortful cognitive self-regulation converge additively or interactively in their statistical prediction of individual differences in harsh parenting? To answer this question, we examined heart rate (HR) and electroencephalography alpha (α) reactivity during executive function (EF) tasks, along with observed and self-reported indicators of harsh parenting. A socioeconomically diverse sample of 115 mothers with 3- to 7-year-old children completed questionnaires and a laboratory visit...
February 2017: Journal of Family Psychology: JFP
https://www.readbyqxmd.com/read/28165248/molecular-modeling-and-adsorption-properties-of-ordered-silica-templated-cmk-mesoporous-carbons
#11
Surendra Kumar Jain, Roland J-M Pellenq, Keith E Gubbins, Xuan Peng
Realistic molecular models of silica-templated CMK-1, CMK-3, and CMK-5 carbon materials have been developed by using carbon rods and carbon pipes that were obtained by adsorbing carbon in a model MCM-41 pore. The interactions between the carbon atoms with the silica matrix were described using the PN-Traz potential, and the interaction between the carbon atoms was calculated by the reactive empirical bond order (REBO) potential. Carbon rods and pipes with different thicknesses were obtained by changing the silica-carbon interaction strength, the temperature, and the chemical potential of carbon vapor adsorption...
February 20, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28163237/biophysical-characterization-of-functionalized-titania-nanoparticles-and-their-application-in-dental-adhesives
#12
Jirun Sun, Elijah J Petersen, Stephanie S Watson, Christopher M Sims, Alexander Kassman, Stanislav Frukhtbeyn, Drago Skrtic, Meryem T Ok, Debbie L Jacobs, Vytas Reipa, Qiang Ye, Bryant C Nelson
: It is demonstrated that carboxylic acid-functionalized titanium dioxide (TiO2) NPs produce significantly higher levels of reactive oxygen species (ROS) after visible light irradiation (400 nm to 800 nm, 1600 mW/cm(2)) in comparison to nonfunctionalized TiO2 NPs. The level of ROS produced under these irradiation conditions was not capable of generating oxidatively induced DNA damage in a cell-free system for TiO2 concentrations of 0.5 mg/L or 5 mg/L. In addition, specific incorporation of the acrylic acid-functionalized TiO2 NPs into dental composites allowed us to utilize the generated ROS to enhance photopolymerization (curing and degree of vinyl conversion (DC)) of resin adhesives and create mechanically superior and biocompatible materials for dental applications...
February 2, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28161777/reactivity-of-phosphorene-with-a-3d-element-trioxide-cro3-considering-van-der-waals-molecular-interactions-a-dft-d2-study
#13
Pamela Rubio-Pereda, Gregorio H Cocoletzi
First-principle calculations are performed to investigate the interaction between clean black phosphorene and the CrO3 molecule which is known to be a powerful oxidizer and a suspected carcinogen. Van der Waals forces are included in all calculations through empirical corrections. Energetics studies are first done to determine the structural stability. Then charge density, Löwdin population analysis and electronic states are evaluated. Results show that the CrO3 molecule, with an acceptor electron character, is chemisorbed on the phosphorene surface inducing minimal geometrical distortions, however, after adsorption, a partial charge gradient is produced between the P atoms located at the phosphorene upper and lower planes...
February 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28157719/preclinical-safety-and-efficacy-evaluation-of-biocas-bioactive-calcium-sulfate-bone-cement
#14
Sony Sandhya, Parayanthala Valappil Mohanan, Arumugan Sabareeswaran, Hari Krishna Varma, Manoj Komath
A new bioactive calcium sulfate-based formulation (named 'BioCaS') has been developed for bone filler applications. This is a self-setting injectable cement where the preset form comprises bassanite obtained from the uniform submicron-sized precursor crystals of gypsum, modified with hydrogen orthophosphate ions. The results of the safety and efficacy evaluation of BioCaS cement, done as per the International Standards and guidelines, are presented in this paper. The study plan consisted of in vitro screening tests of cytotoxicity and haemolysis and in vivo biocompatibility evaluation, including an acute systemic toxicity test (in mice), an intracutaneous reactivity test (in rabbits), a pyrogen test (in rabbits) and a maximization sensitization test (in guinea pigs)...
February 3, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28152064/nrf2-regulates-mass-accrual-and-the-antioxidant-endogenous-response-in-bone-differently-depending-on-the-sex-and-age
#15
Gretel Gisela Pellegrini, Meloney Cregor, Kevin McAndrews, Cynthya Carolina Morales, Linda Doyle McCabe, George P McCabe, Munro Peacock, David Burr, Connie Weaver, Teresita Bellido
Accumulation of reactive oxygen species (ROS) is an important pathogenic mechanism underling the loss of bone mass and strength with aging and other conditions leading to osteoporosis. The transcription factor erythroid 2-related factor2 (Nrf2) plays a central role in activating the cellular response to ROS. Here, we examined the endogenous response of bone regulated by Nrf2, and its relationship with bone mass and architecture in the male and female murine skeleton. Young (3 month-old) and old (15 month-old) Nrf2 knockout (KO) mice of either sex exhibited the expected reduction in Nrf2 mRNA expression compared to wild type (WT) littermates...
2017: PloS One
https://www.readbyqxmd.com/read/28151682/molecular-simulation-of-the-ions-ultraconfined-in-the-nanometer-channel-of-calcium-silicate-hydrate-hydration-mechanism-dynamic-properties-and-influence-on-the-cohesive-strength
#16
Dongshuai Hou, Chuanlin Hu, Zongjin Li
Reactive force field molecular dynamics was utilized to investigate the structure, dynamics, and mechanical nature of different cations solvated in the nanometer-channel of highly disordered calcium silicate hydrate. The local structures of different cations bonded with hydroxyl groups are characterized by the long spatial correlation, bond angel distribution preference, and featured coordinated number, resembling those of the tetra-/penta-/octahedron for cation-oxygen structure in the defective region of the silicate glass...
February 20, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28149403/effect-of-drop-jump-technique-on-the-reactive-strength-index
#17
Artur Struzik, Grzegorz Juras, Bogdan Pietraszewski, Andrzej Rokita
The basic drill of plyometric training aimed at improving lower limb power and jump height is a drop jump. This exercise can be performed using different techniques, which substantially affects jump variables. Therefore, the aim of this study was to compare the values of the reactive strength index (RSI) for countermovement drop jumps (CDJs) and bounce drop jumps (BDJs). The study was carried out in a group of 8 male youth basketball players. The tests were conducted using the AMTI BP600900 force plate to measure ground reaction forces and the Noraxon MyoMotion system to record kinematic data...
September 1, 2016: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28140600/n-h-bond-dissociation-enthalpies-and-facile-h-atom-transfers-for-early-intermediates-of-fe-n2-and-fe-cn-reductions
#18
Jonathan Rittle, Jonas C Peters
Fe-mediated biological nitrogen fixation is thought to proceed via either a sequence of proton and electron transfer steps, concerted H atom transfer steps, or some combination thereof. Regardless of the specifics and whether the intimate mechanism for N2-to-NH3 conversion involves a distal pathway, an alternating pathway, or some hybrid of these limiting scenarios, Fe-NxHy intermediates are implicated that feature reactive N-H bonds. Thermodynamic knowledge of the N-H bond strengths of such species is scant, and is especially difficult to obtain for the most reactive early stage candidate intermediates (e...
February 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28134036/photocrosslinked-tyramine-substituted-hyaluronate-hydrogels-with-tunable-mechanical-properties-improve-immediate-tissue-hydrogel-interfacial-strength-in-articular-cartilage
#19
Patrick E Donnelly, Tony Chen, Anthony Finch, Caroline Brial, Suzanne A Maher, Peter A Torzilli
Articular cartilage lacks the ability to self-repair and a permanent solution for cartilage repair remains elusive. Hydrogel implantation is a promising technique for cartilage repair; however for the technique to be successful hydrogels must interface with the surrounding tissue. The objective of this study was to investigate the tunability of mechanical properties in a hydrogel system using a phenol-substituted polymer, tyramine-substituted hyaluronate (TA-HA), and to determine if the hydrogels could form an interface with cartilage...
April 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28131972/degradation-pathway-and-mechanism-of-reactive-brilliant-red-x-3b-in-electro-assisted-microbial-system-under-anaerobic-condition
#20
Zhanping Cao, Jinghui Zhang, Jingli Zhang, Hongwei Zhang
The degradations of Reactive Brilliant Red X-3B (RBRX-3B) in an electric-assisted microbial system (EAMS), a microbial system (MS) and an electrochemical system (ECS) were compared. The degradation efficiency of RBRX-3B in EAMS (99.8%) was 10.8% higher than the sum in MS (61.9%) and ECS (27.1%) at 24h at the optimal voltage of 0.4V, indicating that there was a synergistic effect between the electrode reaction and the biodegradation. The RBRX-3B degradation in EAMS followed first-order kinetic model. The activation energy of RBRX-3B degradation in EAMS was calculated to be 60...
January 24, 2017: Journal of Hazardous Materials
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