keyword
MENU ▼
Read by QxMD icon Read
search

Martin Leon

keyword
https://www.readbyqxmd.com/read/28079192/differential-cytotoxic-effects-of-graphene-and-graphene-oxide-on-skin-keratinocytes
#1
Marco Pelin, Laura Fusco, Verónica León, Cristina Martín, Alejandro Criado, Silvio Sosa, Ester Vázquez, Aurelia Tubaro, Maurizio Prato
Impressive properties make graphene-based materials (GBMs) promising tools for nanoelectronics and biomedicine. However, safety concerns need to be cleared before mass production of GBMs starts. As skin, together with lungs, displays the highest exposure to GBMs, it is of fundamental importance to understand what happens when GBMs get in contact with skin cells. The present study was carried out on HaCaT keratinocytes, an in vitro model of skin toxicity, on which the effects of four GBMs were evaluated: a few layer graphene, prepared by ball-milling treatment (FLG), and three samples of graphene oxide (GOs, a research-grade GO1, and two commercial GOs, GO2 and GO3)...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28062583/martin-leon-md
#2
Mark Nicholls
No abstract text is available yet for this article.
December 14, 2016: European Heart Journal
https://www.readbyqxmd.com/read/28049490/mobilization-of-hematopoietic-stem-cells-with-the-novel-cxcr4-antagonist-pol6326-balixafortide-in-healthy-volunteers-results-of-a-dose-escalation-trial
#3
Darja Karpova, Susanne Bräuninger, Eliza Wiercinska, Ariane Krämer, Belinda Stock, Jochen Graff, Hans Martin, Achim Wach, Christophe Escot, Garry Douglas, Barbara Romagnoli, Eric Chevalier, Klaus Dembowski, Leon Hooftman, Halvard Bonig
BACKGROUND: Certain disadvantages of the standard hematopoietic stem and progenitor cell (HSPC) mobilizing agent G-CSF fuel the quest for alternatives. We herein report results of a Phase I dose escalation trial comparing mobilization with a peptidic CXCR4 antagonist POL6326 (balixafortide) vs. G-CSF. METHODS: Healthy male volunteer donors with a documented average mobilization response to G-CSF received, following ≥6 weeks wash-out, a 1-2 h infusion of 500-2500 µg/kg of balixafortide...
January 3, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28040180/characterization-of-microbial-population-of-breba-and-main-crops-ficus-carica-during-cold-storage-influence-of-passive-modified-atmospheres-map-and-antimicrobial-extract-application
#4
María Del Carmen Villalobos, Manuel Joaquín Serradilla, Alberto Martín, Alejandro Hernández-León, Santiago Ruíz-Moyano, María de Guía Córdoba
The purpose of this work was to study the changes of bacterial and fungal population of breba fruits such as 'Banane' and 'San Antonio' as well as 'Cuello Dama Negro', 'Cuello Dama Blanco' and 'San Antonio' fig cultivars stored in passive modified atmospheres (MAP) by the use of three different microperforated films (M10 with 16 holes; M30 with five holes and M50 with three holes). Moreover the effects of the application of aqueous soy polyphenolic antimicrobial extract (APE), alone or combined with MAP, were also studied for 'Cuello Dama Negro' and 'Cuello Dama Blanco' fig cultivars...
May 2017: Food Microbiology
https://www.readbyqxmd.com/read/28039322/injuries-to-the-aorta-aortic-annulus-and-left-ventricle-during-transcatheter-aortic-valve-replacement-management-and-outcomes
#5
Nathaniel B Langer, Nadira B Hamid, Tamim M Nazif, Omar K Khalique, Torsten P Vahl, Jonathon White, Juan Terre, Ramin Hastings, Diana Leung, Rebecca T Hahn, Martin Leon, Susheel Kodali, Isaac George
The experience with transcatheter aortic valve replacement is increasing worldwide; however, the incidence of potentially catastrophic cardiac or aortic complications has not decreased. In most cases, significant injuries to the aorta, aortic valve annulus, and left ventricle require open surgical repair. However, the transcatheter aortic valve replacement patient presents a unique challenge as many patients are at high or prohibitive surgical risk and, therefore, an open surgical procedure may not be feasible or appropriate...
January 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28030655/percutaneous-coronary-intervention-with-bioresorbable-scaffolds-in-a-young-child
#6
Tamim M Nazif, Sanjog Kalra, Ziad A Ali, Dimitrios Karmpaliotis, Mariel E Turner, Thomas J Starc, Yang Cao, Charles C Marboe, Michael B Collins, Martin B Leon, Ajay J Kirtane
Importance: Although much less frequent than in adults, coronary artery disease requiring revascularization may develop in children because of homozygous familial hypercholesterolemia or other underlying conditions. Percutaneous coronary intervention (PCI) with a bioresorbable scaffold (BRS) may have advantages over metallic coronary stents in this population. Objective: To present a case of the successful treatment of unstable, multivessel coronary artery disease in a child with PCI with BRS implantation...
December 28, 2016: JAMA Cardiology
https://www.readbyqxmd.com/read/28017714/long-term-valve-performance-of-tavr-and-savr-a-report-from-the-partner-i-trial
#7
Melissa A Daubert, Neil J Weissman, Rebecca T Hahn, Philippe Pibarot, Rupa Parvataneni, Michael J Mack, Lars G Svensson, Deepika Gopal, Samir Kapadia, Robert J Siegel, Susheel K Kodali, Wilson Y Szeto, Raj Makkar, Martin B Leon, Pamela S Douglas
OBJECTIVES: The aim of this study was to evaluate the long-term performance of transcatheter aortic valve replacement (TAVR) and surgical aortic valve replacement (SAVR) through longitudinal echocardiographic analysis. BACKGROUND: The long-term performance of the SAPIEN TAVR is not well-described. Therefore, we examined the hemodynamic and valvular profile of the SAPIEN TAVR over 5 years. METHODS: All patients receiving TAVR or SAVR with first post-implant (FPI) and 5-year echoes were analyzed for aortic valve (AV) peak velocity, AV mean gradient, AV area, peak left ventricular (LV) outflow tract and in-stent velocities, Doppler velocity index, aortic regurgitation (AR), LV mass index, stroke volume index, and cardiac index...
December 8, 2016: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28013412/the-inhibition-of-voltage-gated-h-channel-hvcn1-induces-acidification-of-leukemic-jurkat-t-cells-promoting-cell-death-by-apoptosis
#8
Agustín Asuaje, Paola Smaldini, Pedro Martín, Nicolás Enrique, Alejandro Orlowski, Ernesto A Aiello, Carlos Gonzalez León, Guillermo Docena, Verónica Milesi
Cellular energetic deregulation is widely known to produce an overproduction of acidic species in cancer cells. This acid overload must be counterbalanced with a high rate of H(+) extrusion to maintain cell viability. In this sense, many H(+) transporters have been reported to be crucial for cell survival and proposed as antineoplastic target. By the way, voltage-gated proton channels (Hv1) mediate highly selective H(+) outward currents, capable to compensate acid burden in brief periods of time. This structure is canonically described acting as NADPH oxidase counterbalance in reactive oxygen species production...
December 24, 2016: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28012867/chronic-oral-administration-of-mpep-an-antagonist-of-mglu5-receptor-during-gestation-and-lactation-alters-mglu5-and-a2a-receptors-in-maternal-and-neonatal-brain
#9
Antonio López-Zapata, David Agustín León-Navarro, María Crespo, José Luis Albasanz, Mairena Martín
Antidepressant and anxiolytic drugs are widely consumed even by pregnant and lactating women. The metabotropic glutamate receptor 5 (mGlu5) antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) exerts antidepressant- and anxiolytic-like actions. Given that treatment for anxiety and depression use to be prolonged in time, it is conceivable a possible modulation of metabotropic glutamate receptors (mGlu receptors) after prolonged MPEP exposure, which could also modify adenosine A2A receptors (A2AR) since functional cross-talk between them has been reported...
December 22, 2016: Neuroscience
https://www.readbyqxmd.com/read/27994377/risk-factors-for-early-invasive-fungal-disease-in-critically-ill-patients
#10
Gurmeet Singh, Ceva Wicaksono Pitoyo, Dita Aditianingsih, Cleopas Martin Rumende
BACKGROUND: The incidence of invasive fungal disease (IFD) is increasing worldwide in the past two to three decades. Critically ill patients in Intensive Care Units are more vulnerable to fungal infection. Early detection and treatment are important to decrease morbidity and mortality in critically ill patients. OBJECTIVE: Our study aimed to assess factors associated with early IFD in critically ill patients. MATERIALS AND METHODS: This prospective cohort study was conducted in critically ill patients, from March to September 2015...
November 2016: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/27993081/contribution-of-persistent-organic-pollutant-exposure-to-the-adipose-tissue-oxidative-microenvironment-in-an-adult-cohort-a-multipollutant-approach
#11
Francisco Artacho-Cordón, Josefa León, José M Sáenz, Mariana F Fernández, Piedad Martin-Olmedo, Nicolás Olea, Juan P Arrebola
Despite growing in vitro and in vivo evidence of the putative role of persistent organic pollutants (POPs) in the induction of oxidative damage in cell structures, this issue has been poorly addressed from an epidemiologic perspective. The aim of this study was to explore associations between adipose tissue POP concentrations and the in situ oxidative microenvironment. A cross-sectional study was conducted in a subsample (n = 271) of a previously established cohort, quantifying levels of eight POPs and four groups of oxidative stress biomarkers in adipose tissue...
December 20, 2016: Environmental Science & Technology
https://www.readbyqxmd.com/read/27989846/cortical-areas-involved-in-behavioral-expression-of-external-pallidum-dysfunctions-a-pet-imaging-study-in-non-human-primates
#12
Laurent Galineau, Aurélie Kas, Yulia Worbe, Marion Chaigneau, Anne-Sophie Herard, Martine Guillermier, Thierry Delzescaux, Jean Féger, Philippe Hantraye, Léon Tremblay
The external pallidum (GPe) is a component of the indirect pathway centrally placed in the basal ganglia. Studies already demonstrated that the pharmacological disinhibition of the sensorimotor, associative, and limbic GPe produced dyskinesia, hyperactivity, and compulsive behaviors, respectively. The aim of this study was to investigate the cortical regions altered by the disinhibition of each GPe functional territory. Thus, 5 macaques were injected with bicuculline in sensorimotor, associative, and limbic sites of the GPe producing dyskinesia, hyperactivity, and compulsive behaviors, and underwent in vivo positron tomography with (18)F-2-fluoro-2-deoxy-D-glucose to identify cortical dysfunctions related to GPe disinhibition...
October 28, 2016: NeuroImage
https://www.readbyqxmd.com/read/27970411/tct-236-effects-of-orbital-versus-rotational-atherectomy-facilitated-pci-on-the-coronary-microcirculation
#13
Keyvan Karimi Galougahi, Navdeep Bhatti, Richard Shlofmitz, Philippe Généreux, Jeffrey Moses, Ajay Kirtane, Gregg Stone, Gary Mintz, Dimitri Karmpaliotis, Akiko Maehara, Martin Leon, Ziad Ali
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970384/tct-213-efficacy-and-safety-of-long-versus-short-term-dual-antiplatelet-therapy-following-complex-percutaneous-coronary-intervention-with-drug-eluting-stents-a-collaborative-patient-level-pooled-analysis-of-randomized-controlled-trials
#14
Gennaro Giustino, Alaide Chieffo, Tullio Palmerini, Marco Valgimigli, Fausto Feres, Alexandre Abizaid, Ricardo Costa, Myeong-Ki Hong, Byeong-Keuk Kim, Yangsoo Jang, Hyo-Soo Kim, Kyung Woo Kw Park, Martine Gilard, Marie-Claude Morice, Fadi Sawaya, Gennaro Sardella, George Danias, Philippe Généreux, Bjorn Redfors, Martin Leon, Deepak Bhatt, Gregg Stone, Antonio Colombo
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970209/tct-819-clinical-outcome-in-patients-with-heart-failure-and-moderate-aortic-stenosis
#15
Lennart van Gils, Marie-Annick Clavel, Mara Vollema, Victoria Delgado, Tamim Nazif, Ernest Spitzer, Rebecca Hahn, Jeroen Bax, Martin Leon, Philippe Pibarot, Nicolas Van Mieghem
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970204/tct-82-evaluation-of-current-practices-in-transcatheter-aortic-valve-replacement-the-written-worldwide-tavr-experience-survey
#16
Luis Nombela-Franco, Enrico Cerrato, Tamim Nazif, Helene Eltchaninoff, Lars Sondergaard, Henrique Ribeiro, Marco Barbanti, Fabian Nietlispach, Pierfrancesco Agostoni, Ramiro Trillo, Pilar Jimenez, Fabrizio D'Ascenzo, Olaf Wendler, Gabriel Maluenda, Mao Chen, Corrado Tamburino, Carlos Macaya, Martin Leon, Josep Rodés-Cabau
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970151/tct-77-association-of-residual-mitral-regurgitation-after-transcatheter-aortic-valve-replacement-with-readmission-for-acute-heart-failure-an-analysis-from-partner-1
#17
John Petersen, Eugene Blackstone, Jeevanantham Rajeswaran, David Cohen, Pamela Douglas, Rebecca Hahn, Susheel Kodali, Lars Svensson, Martin Leon
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970068/tct-691-sex-specific-differences-after-transcatheter-or-surgical-aortic-valve-replacement-in-intermediate-risk-patients-an-analysis-from-the-partner-2-randomized-trial
#18
Jonathan White, Darshan Doshi, Mathew Williams, Molly Szerlip, John Squiers, John Webb, Rebecca Hahn, Ajay Kirtane, Claire Litherland, David Cohen, E Murat Tuzcu, Wilson Szeto, Alan Zajarias, S Chris Malaisrie, Maria Alu, Craig Smith, Martin Leon, Michael Mack, Susheel Kodali
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970058/tct-679-diabetes-and-clinical-outcomes-in-intermediate-risk-patients-randomized-to-transcatheter-versus-surgical-aortic-valve-replacement-an-analysis-of-the-partner-2a-trial
#19
Brian Lindman, Yigal Abramowitz, Philippe Pibarot, Nishath Quader, Hersh Maniar, Alan Zajarias, Suzanne Arnold, Rebecca Hahn, Sammy Elmariah, Rakesh Suri, Torsten Vahl, Lars Svensson, Vinod Thourani, Claire Litherland, Maria Alu, Martin Leon, Raj Makkar
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970050/tct-674-sex-specific-outcomes-of-tavr-with-the-sapien-3-valve-insights-from-the-partner-2-s3-high-risk-and-intermediate-risk-cohorts
#20
Molly Szerlip, Sarah Gualano, John Squiers, Jonathon White, Darshan Doshi, Isaac George, Nicolas Vazquez, John Michael Dimaio, Raj Makkar, Mathew Williams, Howard Herrmann, Lars Svensson, John Webb, Rebecca Hahn, Ajay Kirtane, Vasilis Babaliaros, Vinod Thourani, Maria Alu, Susheel Kodali, Martin Leon, Michael Mack
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
keyword
keyword
63190
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"