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Rhematoid arthritis

Guang Zhao, Haifei Zhang
PURPOSE: Rheumatoid arthritis (RA) is a chronic inflammatory disease and Notch pathway plays a pivotal role in synoviocytes involved in progression of RA. METHODS: Herein, we have designed a self-assembled polymeric micelles based on polycaprolactone-polyethylene glycol (PCL-PEG) and polyethylenimine-polyethylene glycol (PEI-PEG) was prepared and loaded with methotrexate and Notch-1 siRNA for the effective treatment of rheumatoid arthritis. RESULTS: The MTX/siRNA-loaded polymeric micelles (siM-PM) showed appreciable cellular uptake in Raw264...
April 20, 2018: Pharmaceutical Research
L Azzi, S Rania, R Vinci, F Spadari, F Croveri, C Scognamiglio, D Farronato, L Tettamanti, A Tagliabue, J Silvestre-Rangil, C Bellintani
Rheumatoid Arthritis is a disease, which can be described as an autoimmune response after molecular mimicry caused by infective agents. The current study aims at evaluating the correlation between Rhematoid Arthritis (RA) and Periodontal Disease (PD), with special attention to the microbioma detected in the gums. Thirty-four patients with RD were recruited into the current study. Among rheumatic parameters, Rheumatoid Factor (RF), anti-citrullinated protein antibody (CCP), HLA-BDR1 and DAS28 were collected...
April 2017: Journal of Biological Regulators and Homeostatic Agents
L Khondker, S I Khan
Psoriatic arthritis is a condition that causes inflammation of the joints of psoriatic patients. Psoriatic arthritis also affects tissues surrounding the joints including tendon and ligaments. Psoriatic arthritis (PsA), recognized for over 100 years, is the second most frequent diagnostic category after Rhematoid Arthritis (RA) and occurring up to 10% of patients with skin psoriasis. Although PsA is a sero-negative arthritis and the absence of rheumatoid factor is a characteristic laboratory finding, it may be present in 3% of psoriatic arthritis (PsA) patients...
July 2014: Mymensingh Medical Journal: MMJ
A A Hombach, D Kofler, G Rappl, H Abken
Recent insight into the balance of self-tolerance and auto-aggression has raised interest in using human regulatory T (Treg) cells for adoptive immunotherapy of unlimited autoimmune diseases including type-1 diabetes, rhematoid arthritis and multiple sclerosis. The therapeutic use of Treg cells, however, is so far hampered by the inefficiency of current protocols in making them accessible for genetic manipulations. We report here that TCR/CD3 stimulation that is accompanied by extensive CD28 costimulation makes human Treg cells susceptible to retroviral gene transfer ex vivo while preserving their properties in vitro and in vivo...
September 2009: Gene Therapy
No abstract text is available yet for this article.
August 7, 1965: British Medical Journal (1857-1980)
No abstract text is available yet for this article.
May 1963: [Sōgō Rinshō] Clinic All-round
No abstract text is available yet for this article.
November 1955: Military Medicine
D Gawryluk, R Langfort, W Suleiman, B Burakowska, E Decker
A case of 51 years old woman with 12-years history of rheumatoid arthritis and secondary Sjoegren's syndrome, who developed EBV-associated diffuse large B-cell lymphoma (Lymphomatoid granulomatosis type) involving lungs, lymph nodes and bone marrow was described.
2000: Pneumonologia i Alergologia Polska
L Arrar, L Selloum, A Maiza, A Touabti, M Allali, K Guenfoud
No abstract text is available yet for this article.
August 1995: Biochemical Society Transactions
J R Levick
A method is described for the determination of the permeability of the blood-joint barrier to specific plasma proteins, using the ratio of protein concentration in synovial fluid to that in plasma. The inadequacy of the ratio per se as a direct index of permeability is discussed. Permeabilities are evaluated for the normal and rheumatoid human knee. Permeability increases in the rhematoid knee by approximately 6 times for the rheumatoid knee by approximately 6 times for albumin and over 40 times for macroglobulins...
December 1981: Arthritis and Rheumatism
C Giles
The Coulter Model S-Plus Counter provides a measure of the platelet count and the mean platelet volume (MPV). An analysis of 5000 unselected blood specimens showed an inverse relationship between the number of circulating platelets and their MPV. In nearly 95% of normal adults the platelet count varied from 150 to 450 X 10(9)/l and the MPV from 7.0 to 10.5 fl. Thrombocytosis was found in iron deficiency anaemia, after trauma and acute blood loss and in rhematoid arthritis. Although there is a normal platelet distribution in pregnancy, patients with pre-eclampsia and uncomplicated hypertension in late pregnancy tended to have lower platelet counts and larger platelets than controls...
May 1981: British Journal of Haematology
J W Leatherman, R K Sibley, S F Davies
Nine patients with diffuse intrapulmonary hemorrhage and glomerulonephritis not due to anti-glomerular basement membrane (anti-GBM) antibody are described and similar previously reported cases are reviewed. Eight patients were seen during a four-year interval and represented 47 percent of the cases of pulmonary hemorrhage and glomerulonephritis seen during this period. Diagnoses included systemic vasculitis of unspecified type in two patients with seropositive rhematoid arthritis, idiopathic crescentic glomerulonephritis with negative immunofluorescence in two, Wegener's granulomatosis in two, and polyarteritis nodosa, Henoch-Schönlein purpura, and mixed connective tissue disease in one each...
March 1982: American Journal of Medicine
G H Fallet, P Wettstein, H Ott, U Mosimann, I Radi
No abstract text is available yet for this article.
September 19, 1970: Schweizerische Medizinische Wochenschrift
U Börngen
No abstract text is available yet for this article.
June 20, 1973: Zeitschrift Für Allgemeinmedizin
G B Bluhm
No abstract text is available yet for this article.
July 22, 1974: JAMA: the Journal of the American Medical Association
J Y Alnot, J H Aubriot, J L Condamine, F Feron, F Langlais, M Miladi, L Pidhorz, G Schneider
No abstract text is available yet for this article.
1988: Revue de Chirurgie Orthopédique et Réparatrice de L'appareil Moteur
R Marcolongo, L Contu
The HL-A phenotypes of 52 patients with rhematoid arthritis and 26 patients with ankylosing spondylitis from an ethnic homogeneous population have been determined. No definite association has been established with rheumatoid arthritis, while a very significant association has been found between ankylosing spondylitis and HL-A 27 antigen. This finding suggests that certain patients with ankylosing spondylitis have a genetically determined susceptibility to their disease which could be due to a cross-tolerance mechanism enabling infectious agent antigens to mimic certain histo-compatibility antigens, or to a linkage between HL-A genes and those controlling immune responsiveness...
April 10, 1975: Biomedicine / [publiée Pour L'A.A.I.C.I.G.]
V A Varshavskiĭ, K L Shakhanina, L A Malkina, I A Borisov, T S Butko
A method for obtaining luminescent sera, consisting in isolation of pure antigens G, A, M from human gamma-globulin and blood serum from patients with myeloma disease is suggested. A native antiserum was obtained by immunization of rabbits with water-insoluble polycondensate of antigens "sewn" with glutaric aldehyde. Adsorption of antisera as well as specific antigens was carried out with antigen- and antibodyimmunosorbent, the latter being obtained with the help of both glutaric aldehyde and sefarose 4B treated with cyanogen bromide...
1975: Arkhiv Patologii
V Konstantinova
The aim of the present study was to determine the significance of the lymphocyte transformation test with phyto-hemagglutinin in connection with the degree of inflammatory activity and serological changes. Lymphocyte transformation test with phytohemagglutinin was performed on 46 of the patients with rheumatoid arthritis active stage, diagnosed according to the New York criteria. In patients with low and moderate inflammatory activity the lymphocyte transformation test has values close to those of the controls...
December 1976: Vŭtreshni Bolesti
E M Veys, E Coigne, H Mielants, A Verbruggen
The authors determined the HLA groups in 1000 blood donors, in 62 subjects suffering from ankylosing spondylarthritis, and in 32 subjects suffering from chronic juvenile polyarthritis. The results confirm those of other authors as regards the occurrence of W27 antigen in ankylosing spondylarthritis. The examination of the subjects suffering from chronic juvenile polyarthritis made it possible to subdivide this population into 4 groups: (1) Chronic juvenile polyarthritis evolving towards ankylosing spondylarthritis; (2) Chronic juvenile polyarthritis with sacroilitis; (3) Chronic juvenile polyarthritis without sacroiliac involvement; and (4) Rhematoid juvenile polyarthritis...
July 1976: Revue du Rhumatisme et des Maladies Ostéo-articulaires
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