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Emission tomography

Hye-Geum Kim, Eun-Jung Kong, Eun-Jin Cheon, Hae-Won Kim, Bon-Hoon Koo
The purpose of this study was to explore the relationship between cerebral amyloid deposition and overall clinical factors including cognitive functions in geriatric depression by using ¹⁸F-florbetaben positron emission tomography. Thirteen subjects aged over 60 years who had a history of major depressive disorder and also had subjective memory complaint were included. Of all subjects, 3 subjects judged as amyloid positive, and the others judged as amyloid negative. Their memory, visuospatial functions and attention abilities were negatively correlated with amyloid deposition in specific brain regions, but their language and recognition abilities were not correlated with any region...
November 30, 2016: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
William D Erwin, Aaron C Jessop, Martha V Mar, Homer A Macapinlac, Osama R Mawlawi
OBJECTIVE: The aim of this study was to assess the feasibility of IQ-SPECT gated blood pool (MUGA) under conditions of decreased scan time (ST). PATIENTS AND METHODS: Ten patients underwent routine 26-min, two-view planar, followed by LEHR and IQ-SPECT MUGA, on a Siemens dual-head Symbia scanner. Six 'back and forth' 4-min SPECT scans were summed into 4-, 8-, 12-, 16-, 20-, and 24-min equivalent scans, and reconstructed iteratively (IQ-SPECT and LEHR) and with FBP (LEHR)...
October 21, 2016: Nuclear Medicine Communications
Sung-Jin Jung, Seong-Kwan Hong, Oh-Kyong Kwon
A readout integrated circuit (ROIC) using two-step fastest signal identification (FSI) is proposed to reduce the number of input channels of a data acquisition (DAQ) block with a high-channel reduction ratio. The two-step FSI enables the proposed ROIC to filter out useless input signals that arise from scattering and electrical noise without using complex and bulky circuits. In addition, an asynchronous fastest signal identifier and a self-trimmed comparator are proposed to identify the fastest signal without using a high-frequency clock and to reduce misidentification, respectively...
October 20, 2016: Sensors
Laura Evangelista, Maria Vittoria Dieci, Valentina Guarneri, Pier Franco Conte
PURPOSE: The aim of the study was to determine the correlation between 16α-18F-fluoro-17β-estradiol (18F-FES) uptake and the expression and functionality of estrogen receptors (ERs), as well as to evaluate the ability of 18F-FES PET to predict the response to hormonal therapy (HT) in patients with locally advanced or metastatic breast cancer (BC). METHODS: Literature searches in the major literature databases were carried out in order to select English-language articles dealing with 18F-FES PET and BC...
October 19, 2016: Current Radiopharmaceuticals
Susanna Nuvoli, Angela Spanu, Giuseppe Madeddu
As well known, the increase in life expectancy and the better physical condition of people in western countries will lead in the next 20 years to a dramatic development of neurodegenerative diseases, especially of dementia that could be considered one of the most important problems in clinical, social and economic fields for the future. Therefore, the differential diagnosis of the various types of dementia is a critical step for patients, clinicians and researchers since an accurate "in vivo" diagnosis can lead to a better patients management...
October 19, 2016: Current Alzheimer Research
Hyeonseok S Jeong, Eun Kyoung Choi, In-Uk Song, Yong-An Chung, Jong-Sik Park, Jin Kyoung Oh
BACKGROUND: In preparation for I-131 ablation, temporary withdrawal of thyroid hormone is commonly used in patients with thyroid cancer after total thyroidectomy. The current study aimed to investigate brain glucose metabolism and its relationships with mood or cognitive function in these patients using 18F-fluoro-2-deoxyglucose positron emission tomography (18F-FDG-PET). METHOD: A total of 40 consecutive adult patients with thyroid carcinoma who had undergone total thyroidectomy were recruited for this cross-sectional study...
October 22, 2016: Thyroid: Official Journal of the American Thyroid Association
Balaraman Kalyanaraman, Micael Hardy, Jacek Zielonka
In this review, potential fluorescent probe applications for detecting reactive oxygen and nitrogen species (ROS/RNS) generated from NADPH oxidases (e.g., Nox2) and nitric oxide synthase enzymes are discussed in the context of pesticide toxicology. Identification of the specific marker products derived from the interaction between ROS/RNS and the fluorescent probes (e.g., hydroethidine and coumarin boronate) is critical. Due to the complex nature of reactions between the probes and ROS/RNS, we suggest avoiding the use of fluorescence microscopy for detecting oxidizing/nitrating species...
August 2016: Current Pharmacology Reports
Mathias Holm Sørgaard, Klaus Fuglsang Kofoed, Jesper James Linde, Richard Thomas George, Carlos Eduardo Rochitte, Gudrun Feuchtner, Joao A C Lima, Jawdat Abdulla
OBJECTIVES: The aim of this study is to provide a meta-analysis of all published studies assessing the diagnostic accuracy of stress CT myocardial perfusion imaging (CTP) in patients suspected of or with known coronary artery disease. This analysis is limited to static stress CTP. METHODS: Systematic literature review and meta-analysis of studies examining the diagnostic accuracy of static CTP imaging alone or combined with coronary CT angiography (CTA) in comparison to single photon emission computed tomography (SPECT), magnetic resonance perfusion (MRP), and/or invasive coronary angiography with and without fractional flow reserve (FFR)...
October 15, 2016: Journal of Cardiovascular Computed Tomography
Sanjay Gambhir, Mritunjai Kumar, Mudalsha Ravina, Sanjeev Kumar Bhoi, Jayantee Kalita, U K Misra
OBJECTIVE: To study the role of (18)fluoro-deoxy glucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) scan in documenting the disease burden in patients with tuberculous meningitis (TBM), and compare these findings with conventional imaging and magnetic resonance imaging (MRI). SUBJECTS AND METHODS: Ten patients with definite TBM were prospectively recruited. The severity of TBM was graded into stage I to III. The patients were subjected to whole body (18)F-FDG PET/CT imaging and MRI brain...
November 15, 2016: Journal of the Neurological Sciences
Yuichi Hayashi, Nobuaki Yoshikura, Akira Takekoshi, Megumi Yamada, Takahiko Asano, Akio Kimura, Katsuya Satoh, Tetsuyuki Kitamoto, Takashi Inuzuka
Creutzfeldt-Jakob disease (CJD) with a causative point mutation of valine to isoleucine at codon 180 (V180I) is one of the major types of genetic CJD (gCJD) in Japan. V180I gCJD is rarely accompanied by a family history, and its clinical characteristics include late-onset, long disease duration, and edematous cortical hyperintensity in diffusion, fluid attenuate inversion and T2-weighted MRI. We performed serial imaging with single-photon emission computed tomography (SPECT) and MRI in three V180I gCJD cases over long-term observation...
November 15, 2016: Journal of the Neurological Sciences
Handoo Rhee, John Blazak, Chui Ming Tham, Keng Lim Ng, Benjamin Shepherd, Malcolm Lawson, John Preston, Ian Vela, Paul Thomas, Simon Wood
BACKGROUND: In this study, we prospectively evaluate the diagnostic potential of a gallium-68 (68Ga) prostate-specific membrane antigen (PSMA)-binding ligand and positron emission tomography (PET) in detecting metastatic lesions in patients with renal tumour. The secondary aim was to determine whether the findings would result in the alteration of patient management. RESULTS: Ten patients with renal lesion and potential metastatic disease on conventional imaging were recruited...
December 2016: EJNMMI Research
Bahar Konuralp Atakul, Salih Taşkın, Çiğdem Soydal, Yavuz Emre Sükür, Alper Kahraman, Kazibe Koyuncu, Erkan İbiş, Firat Ortac
INTRODUCTION: This study evaluated the role of 18F-fluorodeoxyglucose (FDG) positron emission tomography/CT (PET/CT) in the detection of lymph node metastases and the association between uterine maximum standardized uptake values (SUVmax) and the histopathological features in endometrial cancer patients. MATERIALS AND METHODS: Patients with endometrioid endometrial cancer underwent preoperative 18F-FDG PET/CT imaging and were staged surgically. 18F-FDG PET/CT findings were compared with final pathology reports...
October 22, 2016: Gynecologic and Obstetric Investigation
Paul A Ellison, Hector F Valdovinos, Stephen A Graves, Todd E Barnhart, Robert J Nickles
Zirconium-89 finds broad application for use in positron emission tomography. Its cyclotron production has been limited by the heat transfer from yttrium targets at high beam currents. A spot welding technique allows a three-fold increase in beam current, without affecting (89)Zr quality. An yttrium foil, welded to a jet-cooled tantalum support base accommodates a 50µA proton beam degraded to 14MeV. The resulting activity yield of 48±4 MBq/(μA∙hr) now extends the outreach of (89)Zr for a broader distribution...
October 13, 2016: Applied Radiation and Isotopes
Jun Young Lee, Chirag K Vyas, Bo-Ram Kim, Hee Jung Kim, Min Goo Hur, Seung Dae Yang, Jeong Hoon Park, Sang Wook Kim
The (68)Ge/(68)Ga generator system is an excellent source for producing ready-to-use Ga-68 in clinical Positron Emission Tomography (PET) applications. The column adsorbent is the key component for the (68)Ge/(68)Ga generator system. Therefore, several studies have been conducted to identify column materials with a stable and superior elution yield in an acidic eluent (0.1 N HCl solution). In this study, four different zirconium phosphates were synthesized with a particle size of 200-800nm, pore-size of 55∼190Å and surface area of 0...
October 7, 2016: Applied Radiation and Isotopes
Matthew J Budoff, Dong Li, Ella A Kazerooni, Gregory S Thomas, Jennifer H Mieres, Leslee J Shaw
RATIONALE AND OBJECTIVES: Although multiple studies have shown excellent accuracy statistics for noninvasive angiography by coronary computed tomographic angiography (CCTA), most studies comparing nuclear imaging to CCTA were performed on patients already referred for cardiac catheterization, introducing referral and selection bias. This prospective trial evaluated the diagnostic accuracy of 64-row CCTA to detect obstructive coronary stenosis compared to myocardial perfusion imaging (MPI), using quantitative coronary angiography (QCA) as a reference standard...
October 19, 2016: Academic Radiology
Chieh Chang, Susan Shur-Fen Gau, Wen-Sheng Huang, Chyng-Yann Shiue, Chin-Bin Yeh
BACKGROUND/PURPOSE: The aims of the current study were to determine whether patients with conduct disorder (CD) showed an abnormal availability of serotonin reuptake transporter (SERT), and if their hyperkinetic symptoms, impulsivity, and quality of life were correlated with the availability of SERT. METHODS: We recruited 14 drug-naïve patients with CD and eight age-matched healthy controls (HCs). The adult attention-deficit/hyperactivity disorder (ADHD) self-report scale (ASRS), Barrett impulsivity scale (BIS), and the World Health Organization quality of life-brief version (WHOQOL-BREF) scale were administered...
October 19, 2016: Journal of the Formosan Medical Association, Taiwan Yi Zhi
Hulya Yalçin, Ines Valenta, Fatih Yalçin, Celia Corona-Villalobos, Nestor Vasquez, Joshua Ra, Nagehan Kucukler, Abdel Tahari, Iraklis Pozios, Yun Zhou, Martin Pomper, Theodore P Abraham, Thomas H Schindler, M Roselle Abraham
Vasodilator-induced transient left ventricular (LV) cavity dilation by positron emission tomography (PET) is common in patients with hypertrophic cardiomyopathy (HC). Because most patients with PET-LV cavity dilation lack obstructive epicardial coronary artery disease, we hypothesized that vasodilator-induced subendocardial hypoperfusion resulting from microvascular dysfunction underlies this result. To test this hypothesis, we quantified myocardial blood flow (MBF) (subepicardial, subendocardial, and global MBF) and left ventricular ejection fraction (LVEF) in 104 patients with HC without significant coronary artery disease, using (13)NH3-PET...
September 15, 2016: American Journal of Cardiology
Aqiba Bokhari, Patricia G Tiscornia-Wasserman
Renal cell carcinoma metastases to pancreas, thyroid, and contralateral adrenal gland are decidedly uncommon. Clear cell renal cell carcinoma (CCRCC) is the most frequent subtype. Cytology diagnosis may be challenging. A 74-year-old male with remote history of vocal cord malignancy and hypertension presented with abdominal pain. Computed tomography (CT) revealed 8.4 cm left renal mass highly suspicious for renal cell carcinoma, a 1.8 cm mass within vessels near left adrenal and a 2.5 cm mass in pancreatic tail...
October 22, 2016: Diagnostic Cytopathology
Thomas Vanicek, Alexandra Kutzelnigg, Cecile Philippe, Helen L Sigurdardottir, Gregory M James, Andreas Hahn, Georg S Kranz, Anna Höflich, Alexander Kautzky, Tatjana Traub-Weidinger, Marcus Hacker, Wolfgang Wadsak, Markus Mitterhauser, Siegfried Kasper, Rupert Lanzenberger
Altered serotonergic neurotransmission has been found to cause impulsive and aggressive behavior, as well as increased motor activity, all exemplifying key symptoms of ADHD. The main objectives of this positron emission tomography (PET) study were to investigate the serotonin transporter binding potential (SERT BPND ) in patients with ADHD and to assess associations of SERT BPND between the brain regions. 25 medication-free patients with ADHD (age ± SD; 32.39 ± 10.15;10 females) without any psychiatric comorbidity and 25 age and sex matched healthy control subjects (33...
October 22, 2016: Human Brain Mapping
Mathias Kranz, Bernhard Sattler, Solveig Tiepolt, Stephan Wilke, Winnie Deuther-Conrad, Cornelius K Donat, Steffen Fischer, Marianne Patt, Andreas Schildan, Jörg Patt, René Smits, Alexander Hoepping, Jörg Steinbach, Osama Sabri, Peter Brust
BACKGROUND: Both enantiomers of [(18)F]flubatine are new radioligands for neuroimaging of α4β2 nicotinic acetylcholine receptors with positron emission tomography (PET) exhibiting promising pharmacokinetics which makes them attractive for different clinical questions. In a previous preclinical study, the main advantage of (+)-[(18)F]flubatine compared to (-)-[(18)F]flubatine was its higher binding affinity suggesting that (+)-[(18)F]flubatine might be able to detect also slight reductions of α4β2 nAChRs and could be more sensitive than (-)-[(18)F]flubatine in early stages of Alzheimer's disease...
December 2016: EJNMMI Physics
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