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https://www.readbyqxmd.com/read/27589570/prognostic-value-of-pdl1-expression-in-pancreatic-cancer
#1
David J Birnbaum, Pascal Finetti, Alexia Lopresti, Marine Gilabert, Flora Poizat, Olivier Turrini, Jean-Luc Raoul, Jean-Robert Delpero, Vincent Moutardier, Daniel Birnbaum, Emilie Mamessier, Fran├žois Bertucci
Pancreatic cancer is one of the most aggressive human cancers. PD1/PDL1-inhibitors recently showed promising results in different cancers with correlation between PDL1 tumor expression and responses. Expression of programmed cell death receptor ligand 1 (PDL1) has been scarcely studied in pancreatic cancer. In this retrospective study, we analyzed PDL1 mRNA expression in 453 clinical pancreatic cancer samples profiled using DNA microarrays and RNASeq. Compared to normal pancreatic samples, PDL1 expression was upregulated in 19% of cancer samples...
August 29, 2016: Oncotarget
https://www.readbyqxmd.com/read/27228053/follicular-lymphoma-tregs-have-a-distinct-transcription-profile-impacting-their-migration-and-retention-in-the-malignant-lymph-node
#2
Hristina Nedelkovska, Alexander F Rosenberg, Shannon P Hilchey, Ollivier Hyrien, W Richard Burack, Sally A Quataert, Christina M Baker, Mitra Azadniv, Stephen L Welle, Stephen M Ansell, Minsoo Kim, Steven H Bernstein
We have previously shown that regulatory T cells (Tregs) infiltrating follicular lymphoma lymph nodes are quantitatively and qualitatively different than those infiltrating normal and reactive nodes. To gain insight into how such Treg populations differ, we performed RNA sequence (RNAseq) analyses on flow sorted Tregs from all three sources. We identify several molecules that could contribute to the observed increased suppressive capacity of follicular lymphoma nodal tregs, including upregulation of CTLA-4, IL-10, and GITR, all confirmed by protein expression...
2016: PloS One
https://www.readbyqxmd.com/read/25264896/foxp3-expression-in-macrophages-associated-with-renca-tumors-in-mice
#3
Christel Devaud, Carmen S M Yong, Liza B John, Jennifer A Westwood, Connie P M Duong, Colin M House, Delphine Denoyer, Jason Li, Phillip K Darcy, Michael H Kershaw
The transcription factor Foxp3 represents the most specific functional marker of CD4+ regulatory T cells (TRegs). However, previous reports have described Foxp3 expression in other cell types including some subsets of macrophages, although there are conflicting reports and Foxp3 expression in cells other than Treg is not well characterized. We performed detailed investigations into Foxp3 expression in macrophages in the normal tissue and tumor settings. We detected Foxp3 protein in macrophages infiltrating mouse renal cancer tumors injected subcutaneously or in the kidney...
2014: PloS One
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