keyword
https://read.qxmd.com/read/38494386/suppressor-t-helper-type-17-cell-responses-in-intestinal-transplant-recipients-with-allograft-rejection
#1
JOURNAL ARTICLE
Leonid Belyayev, Jiman Kang, Mohammed Sadat, Katrina Loh, Digvijay Patil, Vinona Muralidaran, Khalid Khan, Stuart Kaufman, Sukanya Subramanian, Yuriy Gusev, Krithika Bhuvaneshwar, Habtom Ressom, Rency Varghese, Udeme Ekong, Cal S Matsumoto, Simon C Robson, Thomas M Fishbein, Alexander Kroemer
BACKGROUND: Intestinal transplant (ITx) rejection is associated with memory T helper type 17 cell (Th17) infiltration of grafted tissues. Modulation of Th17 effector cell response is facilitated by T regulatory (Treg) cells, but a phenotypic characterization of this process is lacking in the context of allograft rejection. METHODS: Flow cytometry was performed to examine the expression of surface receptors, cytokines, and transcription factors in Th17 and Treg cells in ITx control (n = 34) and rejection patients (n = 23)...
March 16, 2024: Human Immunology
https://read.qxmd.com/read/38419761/msc-derived-exosomes-attenuate-hepatic-fibrosis-in-primary-sclerosing-cholangitis-through-inhibition-of-th17-differentiation
#2
JOURNAL ARTICLE
Wenyi Chen, Feiyan Lin, Xudong Feng, Qigu Yao, Yingduo Yu, Feiqiong Gao, Jiahang Zhou, Qiaoling Pan, Jian Wu, Jinfeng Yang, Jiong Yu, Hongcui Cao, Lanjuan Li
Primary sclerosing cholangitis (PSC) is an autoimmune cholangiopathy characterized by chronic inflammation of the biliary epithelium and periductal fibrosis, with no curative treatment available, and liver transplantation is inevitable for end-stage patients. Human placental mesenchymal stem cell (hpMSC)-derived exosomes have demonstrated the ability to prevent fibrosis, inhibit collagen production and possess immunomodulatory properties in autoimmune liver disease. Here, we prepared hpMSC-derived exosomes (ExoMSC ) and further investigated the anti-fibrotic effects and detailed mechanism on PSC based on Mdr2-/- mice and multicellular organoids established from PSC patients...
February 2024: Asian journal of pharmaceutical sciences
https://read.qxmd.com/read/38294569/adipose-derived-stem-cell-exosomes-promote-tumor-characterization-and-immunosuppressive-microenvironment-in-breast-cancer
#3
JOURNAL ARTICLE
Qin Zhu, Yukun Cao, Jiaqi Yuan, Yu Hu
Adipose-derived stem cells (ASC) or autologous fat transplantation could be used to ameliorate breast cancer postoperative deformities. This study aims to explore the action of ASC and ASC-exosomes (ASC-exos) in breast cancer characterization and tumor microenvironment immunity, which provided a new method into the application of ASC-exos. ASC were extracted from human adipose tissue for the isolation and verification of ASC-exos. ASC-exos were co-cultured with CD4+ T cells, CD14+ monocytes and MCF-7 cells, respectively...
January 31, 2024: Cancer Immunology, Immunotherapy: CII
https://read.qxmd.com/read/38234838/immuno-responsive-gene-1-a-mitochondrial-gene-regulates-pathogenic-th17-in-cns-autoimmunity-mouse-model
#4
Mohammad Nematullah, Mena Fatma, Faraz Rashid, Kameshwar Ayasolla, Mohammad Ejaz Ahmed, Sajad Mir, Insha Zahoor, Ramandeep Rattan, Shailendra Giri
Pathogenic Th17 cells are crucial to CNS autoimmune diseases like multiple sclerosis (MS), though their control by endogenous mechanisms is unknown. RNAseq analysis of brain glial cells identified immuno-responsive gene 1 ( Irg1 ), a mitochondrial-related enzyme-coding gene, as one of the highly upregulated gene under inflammatory conditions which were further validated in the spinal cord of animals with experimental autoimmune encephalomyelitis (EAE), an animal model of MS. Moreover, Irg1 mRNA and protein levels in myeloid, CD4, and B cells were higher in the EAE group, raising questions about its function in CNS autoimmunity...
December 25, 2023: bioRxiv
https://read.qxmd.com/read/37940345/mdr1-expressing-cd4-t-cells-with-th1-17-features-resist-to-neoadjuvant-chemotherapy-and-are-associated-with-breast-cancer-clinical-response
#5
JOURNAL ARTICLE
Anthony Di Roio, Margaux Hubert, Laurie Besson, Marion Bossennec, Céline Rodriguez, Yenkel Grinberg-Bleyer, Guilhem Lalle, Lyvia Moudombi, Raphael Schneider, Cyril Degletagne, Isabelle Treilleux, Daniel J Campbell, Séverine Metzger, Thomas Duhen, Olivier Trédan, Christophe Caux, Christine Ménétrier-Caux
BACKGROUND: Multidrug resistance-1 (MDR1) transporter limits the intracellular accumulation of chemotherapies (paclitaxel, anthracyclines) used in breast cancer (BC) treatment. In addition to tumor cells, MDR1 is expressed on immune cell subsets in which it confers chemoresistance. Among human T cells, MDR1 is expressed by most CD8+ T cells, and a subset of CD4+ T helper (Th) cells. Here we explored the expression, function and regulation of MDR1 on CD4+ T cells and investigated the role of this population in response to neoadjuvant chemotherapy (NAC) in BC...
November 2023: Journal for Immunotherapy of Cancer
https://read.qxmd.com/read/37119871/the-neglected-twin-nummular-eczema-is-a-variant-of-atopic-dermatitis-with-codominant-t-h-2-t-h-17-immune-response
#6
JOURNAL ARTICLE
Alexander Böhner, Manja Jargosch, Nikola S Müller, Natalie Garzorz-Stark, Caroline Pilz, Felix Lauffer, Rosi Wang, Sophie Roenneberg, Alexander Zink, Jenny Thomas, Fabian J Theis, Tilo Biedermann, Stefanie Eyerich, Kilian Eyerich
BACKGROUND: Nummular eczema (NE) is a common chronic inflammatory skin disease characterized by multiple, pruritic, discoid-shaped lesions. Since the underlying immune mechanisms are not fully understood, it is unclear whether NE should be regarded as variant of atopic dermatitis (AD) or a distinct disease. OBJECTIVE: We compared the clinical, histopathologic, and molecular signatures of NE with that of type 2 and type 3 skin diseases. METHODS: We performed bulk RNA sequencing as well as histologic and clinical studies in lesional and nonlesional skin biopsy specimens from NE (n = 50), AD (n = 47), and psoriasis (n = 90) patients...
August 2023: Journal of Allergy and Clinical Immunology
https://read.qxmd.com/read/36027951/proinflammatory-changes-in-the-maternal-circulation-maternal-fetal-interface-and-placental-transcriptome-in-preterm-birth
#7
JOURNAL ARTICLE
Camille Couture, Marie-Eve Brien, Ines Boufaied, Cyntia Duval, Dorothee Dal Soglio, Elizabeth Ann L Enninga, Brian Cox, Sylvie Girard
BACKGROUND: Preterm birth remains a leading obstetrical complication because of the incomplete understanding of its multifaceted etiology. It is known that immune alterations toward a proinflammatory profile are observed in women with preterm birth, but therapeutic interventions are still lacking because of scarcity of evidence in the integration of maternal and placental interrelated compartments. OBJECTIVE: This study aimed to obtain an integrated view of the maternal and placental contribution to preterm birth compared with normal term pregnancies for an in-depth understanding of the immune/inflammatory involvement, intending to identify novel strategies to mitigate the negative impact of inflammation...
March 2023: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/35418673/adp-ribosylating-adjuvant-reveals-plasticity-in-cdc1-cells-that-drive-mucosal-th17-cell-development-and-protection-against-influenza-virus-infection
#8
JOURNAL ARTICLE
Mohammad Arabpour, Cristina Lebrero-Fernandez, Karin Schön, Anneli Strömberg, Vanja Börjesson, Katharina Lahl, Marlies Ballegeer, Xavier Saelens, Davide Angeletti, William Agace, Nils Lycke
Migratory dendritic cells expressing CD103 are the targets for mucosal vaccines. These belong to either of two lineage-restricted subsets, cDC1 or cDC2 cells, which have been linked to priming of functionally distinct CD4 T cells. However, recent studies have identified plasticity in cDC2 cells with overlapping functions with cDC1 cells, while the converse has not been reported. We genetically engineered a vaccine adjuvant platform that targeted the cholera toxin A1 (CTA1) ADP-ribosylating enzyme to CD103+ cDC1 and cDC2 cells using a single-chain antibody (scFv) to CD103...
April 2022: Mucosal Immunology
https://read.qxmd.com/read/35008096/rna-sequencing-of-chronic-gvhd-skin-lesions-defines-shared-and-unique-inflammatory-pathways-characterizing-lichen-planus-and-morphea
#9
JOURNAL ARTICLE
Habib Zouali, Juliette Lemasson, Andreea Calugareanu, Christophe Battail, David Michonneau, Hélène le Buanec, Chloé Grolleau, Charles Cassius, Marie Robin, Marine Merandet, Gabor Dobos, Thibault Mahevas, Michel Rybojad, Adèle de Masson, Reyhan Amode, Anne Boland, Laurence Michel, Flore Sicre de Fontbrune, Régis Peffault de Latour, Patrick Bruneval, Hafid Ait-Oufella, Maxime Battistella, Marie Jachiet, Martine Bagot, Jean-François Deleuze, Gérard Socié, Jean-David Bouaziz
Cutaneous involvement of chronic graft-versus-host disease (cGVHD) has a wide range of manifestations including a lichenoid form with a currently assumed mixed Th1/Th17 signature and a sclerotic form with Th1 signature. Despite substantial heterogeneity of innate and adaptive immune cells recruited to the skin and of the different clinical manifestations, treatment depends mainly on the severity of the skin involvement and relies on systemic, high-dose glucocorticoids alone or in combination with a calcineurin inhibitor...
May 10, 2022: Blood Advances
https://read.qxmd.com/read/34851736/short-palate-lung-and-nasal-epithelial-clone-1-splunc1-level-determines-steroid-resistant-airway-inflammation-in-aging
#10
JOURNAL ARTICLE
Anil Kumar Jaiswal, Jyoti Yadav, Sangeet Makhija, Maninder Sandey, Amol Suryawanshi, Amit Kumar Mitra, Amarjit Mishra
Asthma and its heterogeneity change with age. Increased airspace neutrophil numbers contribute to severe steroid-resistant asthma exacerbation in the elderly, which correlates with the changes seen in adults with asthma. However, whether that resembles the same disease mechanism and pathophysiology in aged and adults is poorly understood. Here, we sought to address the underlying molecular mechanism of steroid-resistant airway inflammation development and response to corticosteroid (Dex) therapy in aged mice...
January 1, 2022: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://read.qxmd.com/read/34724272/primary-alterations-during-the-development-of-hidradenitis-suppurativa
#11
JOURNAL ARTICLE
Z Dajnoki, O Somogyi, B Medgyesi, A Jenei, L Szabó, K Gáspár, Z Hendrik, P Gergely, D Imre, S Póliska, D Törőcsik, C C Zouboulis, E P Prens, A Kapitány, A Szegedi
BACKGROUND: Hidradenitis suppurativa (HS) is a chronic, inflammatory disease of the apocrine gland-rich (AGR) skin region. The initial steps of disease development are not fully understood, despite intense investigations into immune alterations in lesional HS skin. OBJECTIVES: We aimed to systematically investigate the inflammatory molecules involved in three stages of HS pathogenesis, including healthy AGR, non-lesional HS and lesional HS skin, with the parallel application of multiple mRNA and protein-based methods...
March 2022: Journal of the European Academy of Dermatology and Venereology: JEADV
https://read.qxmd.com/read/34660300/expression-levels-of-three-key-genes-ccnb1-cdc20-and-cenpf-in-hcc-are-associated-with-antitumor-immunity
#12
JOURNAL ARTICLE
Tengfei Si, Zhenlin Huang, Yuanhang Jiang, Abigail Walker-Jacobs, Shaqira Gill, Robert Hegarty, Mohammad Hamza, Shirin Elizabeth Khorsandi, Wayel Jassem, Nigel Heaton, Yun Ma
Introduction: Hepatocellular carcinoma (HCC) is the most common primary liver cancer with a low 5-year survival rate. The heterogeneity of HCC makes monotherapy unlikely. The development of diagnostic programs and new treatments targeting common genetic events in the carcinogenic process are providing further insights into the management of HCC. The aim of this study was firstly to validate key genes that are involved in promoting HCC development and as biomarkers for early diagnosis and, secondly, to define their links with antitumor immunity including inhibitory checkpoints...
2021: Frontiers in Oncology
https://read.qxmd.com/read/33962693/dual-rnaseq-highlights-the-kinetics-of-skin-microbiome-and-fish-host-responsiveness-to-bacterial-infection
#13
JOURNAL ARTICLE
J Le Luyer, Q Schull, P Auffret, P Lopez, M Crusot, C Belliard, C Basset, Q Carradec, J Poulain, S Planes, D Saulnier
BACKGROUND: Tenacibaculum maritimum is a fish pathogen known for causing serious damage to a broad range of wild and farmed marine fish populations worldwide. The recently sequenced genome of T. maritimum strain NCIMB 2154T provided unprecedented information on the possible molecular mechanisms involved in the virulence of this species. However, little is known about the dynamic of infection in vivo, and information is lacking on both the intrinsic host response (gene expression) and its associated microbiota...
May 7, 2021: Animal microbiome
https://read.qxmd.com/read/33454392/the-imbalance-of-the-th17-treg-axis-following-equine-ascending-placental-infection
#14
JOURNAL ARTICLE
C E Fedorka, H El-Sheikh Ali, O F Walker, K E Scoggin, P Dini, S C Loux, M H T Troedsson, B A Ball
Ascending placentitis is a leading cause of abortion in the horse, but adaptive immune response to this disease is unknown. To evaluate this, sub-acute placentitis was experimentally-induced via trans-cervical inoculation of S. zooepidemicus, and endometrium and chorioallantois was collected 8 days later (n = 6 inoculated/n = 6 control). The expression of transcripts relating to Th1, Th2, Th17, and Treg maturation was assessed via RNASeq. IHC of transcription factors relating to each subtype in the same tissues (Th1: TBX21, Th2: GATA3, Th17: IRF4, Treg: FOXp3)...
April 2021: Journal of Reproductive Immunology
https://read.qxmd.com/read/33329590/rna-sequencing-keloid-transcriptome-associates-keloids-with-th2-th1-th17-th22-and-jak3-skewing
#15
JOURNAL ARTICLE
Jianni Wu, Ester Del Duca, Michael Espino, Alyssa Gontzes, Inna Cueto, Ning Zhang, Yeriel D Estrada, Ana B Pavel, James G Krueger, Emma Guttman-Yassky
Keloids are disfiguring, fibroproliferative growths and their pathogenesis remains unclear, inhibiting therapeutic development. Available treatment options have limited efficacy and harbor safety concerns. Thus, there is a great need to clarify keloid pathomechanisms that may lead to novel treatments. In this study, we aimed to elucidate the profile of lesional and non-lesional keloid skin compared to normal skin. We performed gene (RNAseq, qRT-PCR) and protein (immunohistochemistry) expression analyses on biopsy specimens obtained from lesional and non-lesional skin of African American (AA) keloid patients compared to healthy skin from AA controls...
2020: Frontiers in Immunology
https://read.qxmd.com/read/32679208/microbiome-induced-antigen-presenting-cell-recruitment-coordinates-skin-and-lung-allergic-inflammation
#16
JOURNAL ARTICLE
Niki D Ubags, Aurélien Trompette, Julie Pernot, Britt Nibbering, Nicholas C Wong, Céline Pattaroni, Alexis Rapin, Laurent P Nicod, Nicola L Harris, Benjamin J Marsland
BACKGROUND: Allergic skin inflammation often presents in early childhood; however, little is known about the events leading to its initiation and whether it is transient or long-term in nature. OBJECTIVE: We sought to determine the immunologic rules that govern skin inflammation in early life. METHODS: Neonatal and adult mice were epicutaneously sensitized with allergen followed by airway allergen challenge. Epicutaneous application of labeled allergen allowed for determination of antigen uptake and processing by antigen-presenting cells...
March 2021: Journal of Allergy and Clinical Immunology
https://read.qxmd.com/read/32632096/mir-21-antagonism-abrogates-th17-tumor-promoting-functions-in-multiple-myeloma
#17
JOURNAL ARTICLE
Marco Rossi, Emanuela Altomare, Cirino Botta, Maria Eugenia Gallo Cantafio, Sarai Sarvide, Daniele Caracciolo, Caterina Riillo, Marco Gaspari, Domenico Taverna, Francesco Conforti, Paola Critelli, Bernardo Bertucci, Michelangelo Iannone, Nicoletta Polerà, Domenica Scumaci, Mariamena Arbitrio, Nicola Amodio, Maria Teresa Di Martino, Bruno Paiva, Pierosandro Tagliaferri, Pierfrancesco Tassone
Multiple myeloma (MM) is tightly dependent on inflammatory bone marrow microenvironment. IL-17 producing CD4+ T cells (Th17) sustain MM cells growth and osteoclasts-dependent bone damage. In turn, Th17 differentiation relies on inflammatory stimuli. Here, we investigated the role of miR-21 in Th17-mediated MM tumor growth and bone disease. We found that early inhibition of miR-21 in naive T cells (miR-21i-T cells) impaired Th17 differentiation in vitro and abrogated Th17-mediated MM cell proliferation and osteoclasts activity...
March 2021: Leukemia
https://read.qxmd.com/read/32571132/airborne-particulate-matter-from-goat-farm-increases-acute-allergic-airway-responses-in-mice
#18
JOURNAL ARTICLE
Dingyu Liu, James G Wagner, Rob Mariman, Jack R Harkema, Miriam E Gerlofs-Nijland, Elena Pinelli, Gert Folkerts, Flemming R Cassee, Rob J Vandebriel
Background: Inhalation exposure to biological particulate matter (BioPM) from livestock farms may provoke exacerbations in subjects suffering from allergy and asthma. The aim of this study was to use a murine model of allergic asthma to determine the effect of BioPM derived from goat farm on airway allergic responses. Methods: Fine (<2.5 μm) BioPM was collected from an indoor goat stable. Female BALB/c mice were ovalbumin (OVA) sensitized and challenged with OVA or saline as control. The OVA and saline groups were divided in sub-groups and exposed intranasally to different concentrations (0, 0...
May 2020: Inhalation Toxicology
https://read.qxmd.com/read/32534231/comparative-transcriptomics-reveal-conserved-impacts-of-rearing-density-on-immune-response-of-two-important-aquaculture-species
#19
JOURNAL ARTICLE
Amy R Ellison, Tamsyn M Uren Webster, Deiene Rodriguez-Barreto, Carlos Garcia de Leaniz, Sofia Consuegra, Pablo Orozco-terWengel, Jo Cable
Infectious diseases represent an important barrier to sustainable aquaculture development. Rearing density can substantially impact fish productivity, health and welfare in aquaculture, including growth rates, behaviour and, crucially, immune activity. Given the current emphasis on aquaculture diversification, stress-related indicators broadly applicable across species are needed. Utilising an interspecific comparative transcriptomic (RNAseq) approach, we compared gill gene expression responses of Atlantic salmon (Salmo salar) and Nile tilapia (Oreochromis niloticus) to rearing density and Saprolegnia parasitica infection...
September 2020: Fish & Shellfish Immunology
https://read.qxmd.com/read/31669080/the-proteomic-skin-profile-of-moderate-to-severe-atopic-dermatitis-patients-shows-an-inflammatory-signature
#20
JOURNAL ARTICLE
Ana B Pavel, Lisa Zhou, Aisleen Diaz, Benjamin Ungar, Joshua Dan, Helen He, Yeriel D Estrada, Hui Xu, Marie Fernandes, Yael Renert-Yuval, James G Krueger, Emma Guttman-Yassky
BACKGROUND: Moderate-to-severe atopic dermatitis (AD) is increasingly recognized as a systemic disease, largely due to proteomic blood studies. There are growing efforts to develop AD biomarkers using minimal tissues. OBJECTIVE: To characterize the AD skin proteomic signature and its relationship with the blood proteome and genomic skin profile in the same individuals. METHODS: We evaluated lesional and nonlesional biopsy samples and blood from 20 individuals with moderate-to-severe AD and 28 healthy individuals using Olink Proteomics (Uppsala, Sweden), using 10 μg/10 μL for skin and blood and RNA sequencing of the skin...
March 2020: Journal of the American Academy of Dermatology
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