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Th17 RNAseq

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https://www.readbyqxmd.com/read/27385777/lineage-specific-effector-signatures-of-invariant-nkt-cells-are-shared-amongst-%C3%AE-%C3%AE-t-innate-lymphoid-and-th-cells
#1
You Jeong Lee, Gabriel J Starrett, Seungeun Thera Lee, Rendong Yang, Christine M Henzler, Stephen C Jameson, Kristin A Hogquist
Invariant NKT cells differentiate into three predominant effector lineages in the steady state. To understand these lineages, we sorted undifferentiated invariant NK T progenitor cells and each effector population and analyzed their transcriptional profiles by RNAseq. Bioinformatic comparisons were made to effector subsets among other lymphocytes, specifically Th cells, innate lymphoid cells (ILC), and γδ T cells. Myc-associated signature genes were enriched in NKT progenitors, like in other hematopoietic progenitors...
August 15, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/25255226/human-cd117-ckit-innate-lymphoid-cells-have-a-discrete-transcriptional-profile-at-homeostasis-and-are-expanded-during-filarial-infection
#2
Alexis Boyd, José M C Ribeiro, Thomas B Nutman
Since innate lymphoid cells (ILCs) have been found to play a role in the immune response to helminth parasites in rodents, we sought to determine their role in human helminth infection. By developing multicolor flow cytometry-based methods to identify and enumerate circulating ILCs and their subsets, we were able to identify a subset of cKit+ ILCs defined as Lineage (Lin)-/CD45+/cKit+/CD127+ that were significantly expanded in the filarial-infected individuals (p=0.0473) as were those cKit+ ILCs that produced IL-13...
2014: PloS One
https://www.readbyqxmd.com/read/22715389/effector-cd4-t-cell-expression-signatures-and-immune-mediated-disease-associated-genes
#3
Wei Zhang, John Ferguson, Sok Meng Ng, Ken Hui, Gerald Goh, Aiping Lin, Enric Esplugues, Richard A Flavell, Clara Abraham, Hongyu Zhao, Judy H Cho
Genome-wide association studies (GWAS) in immune-mediated diseases have identified over 150 associated genomic loci. Many of these loci play a role in T cell responses, and regulation of T cell differentiation plays a critical role in immune-mediated diseases; however, the relationship between implicated disease loci and T cell differentiation is incompletely understood. To further address this relationship, we examined differential gene expression in naïve human CD4+ T cells, as well as in in vitro differentiated Th1, memory Th17-negative and Th17-enriched CD4+ T cells subsets using microarray and RNASeq...
2012: PloS One
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