Robert Y S Cheng, Lisa A Ridnour, Adelaide L Wink, Ana L Gonzalez, Elise L Femino, Helene Rittscher, Veena Somasundaram, William F Heinz, Leandro Coutinho, M Cristina Rangel, Elijah F Edmondson, Donna Butcher, Robert J Kinders, Xiaoxian Li, Stephen T C Wong, Daniel W McVicar, Stephen K Anderson, Milind Pore, Stephen M Hewitt, Timothy R Billiar, Sharon A Glynn, Jenny C Chang, Stephen J Lockett, Stefan Ambs, David A Wink
A strong correlation between NOS2 and COX2 tumor expression and poor clinical outcomes in ER breast cancer has been established. However, the mechanisms of tumor induction of these enzymes are unclear. Analysis of The Cancer Genome Atlas (TCGA) revealed correlations between NOS2 and COX2 expression and Th1 cytokines. Herein, single-cell RNAseq analysis of TNBC cells shows potent NOS2 and COX2 induction by IFNγ combined with IL1β or TNFα. Given that IFNγ is secreted by cytolytic lymphocytes, which improve clinical outcomes, this role of IFNγ presents a dichotomy...
May 11, 2023: Cell Death & Disease