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peritoneal mesothelioma

Adeline Tan, Paul Cohen, Mooska Raoofi, Jason Tan, Nima Mesbah Ardakani, Greg Sterrett
No abstract text is available yet for this article.
February 2016: Pathology
Fabio Bozzi, Silvia Brich, Gian Paolo Dagrada, Tiziana Negri, Elena Conca, Barbara Cortelazzi, Antonino Belfiore, Federica Perrone, Ambra Vittoria Gualeni, Annunziata Gloghini, Antonello Cabras, Monica Brenca, Roberta Maestro, Nadia Zaffaroni, Paolo Casali, Rossella Bertulli, Marcello Deraco, Silvana Pilotti
The aim of this study was to reconsider the biological characteristics of epithelioid malignant peritoneal mesothelioma (E-MpM) in the light of new concepts about epithelial mesenchymal transition and mesenchymal epithelial reverse transition (EMT/MErT) and the role of epigenetic reprogramming in this context. To this end we profiled surgical specimens and derived cells cultures by a number of complementary approaches i.e. immunohistochemistry, immunofluorescence, in situ hybridization, biochemistry, pluripotent stem cell arrays, treatments with cytokines, growth factors and specific inhibitors...
September 26, 2016: Oncotarget
Jeffrey L Levin, Alina Rouk, Sara Shepherd, George A Hurst, Jerry W McLarty
The Tyler asbestos plant produced pipe insulation from 1954 to 1972 and exclusively used amosite asbestos. There were 1130 former workers of this plant during the period of operation. A death certificate mortality analysis was published regarding this plant in 1998 for the period through 1993. This study represents an update of the mortality analysis with additional certificates collected for deaths occurring through 2011.Searches of the National Death Index database were conducted in 2004 and again in 2013...
2016: Journal of Toxicology and Environmental Health. Part B, Critical Reviews
David Larson, Amy Powers, Jean-Paul Ambrosi, Mika Tanji, Andrea Napolitano, Erin G Flores, Francine Baumann, Laura Pellegrini, Cormac J Jennings, Brenda J Buck, Brett T McLaurin, Doug Merkler, Cleo Robinson, Paul Morris, Meral Dogan, A Umran Dogan, Harvey I Pass, Sandra Pastorino, Michele Carbone, Haining Yang
Similar to asbestos fibers, nonregulated mineral fibers can cause malignant mesothelioma (MM). Recently, increased proportions of women and young individuals with MM were identified in southern Nevada, suggesting that environmental exposure to carcinogenic fibers was causing the development of MM. Palygorskite, a fibrous silicate mineral with a history of possible carcinogenicity, is abundant in southern Nevada. In this study, our aim was to determine whether palygorskite was contributing to the development of MM in southern Nevada...
2016: Journal of Toxicology and Environmental Health. Part B, Critical Reviews
Joseph Kattan, Roland Eid, Hampig Raphael Kourie, Fadi Farhat, Marwan Ghosn, Claude Ghorra, Roland Tomb
BACKGROUND: Mesotheliomas are relatively rare tumors in Lebanon. The only previous study goes back to 14 years ago, when we published epidemiological characteristics of mesotheliomas in Lebanon, showing that the pleural location accounted for the vast majority of cases, with clear evidence of asbestos exposure from the Eternit factory of Chekka region. The objective of this current study was to estimate the incidence of mesothelioma in the past decade and to identify its epidemiological, clinical and therapeutic characteristics, making comparisons with our first study published in 2001...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
Virginia Spanò, Marzia Pennati, Barbara Parrino, Anna Carbone, Alessandra Montalbano, Alessia Lopergolo, Valentina Zuco, Denis Cominetti, Patrizia Diana, Girolamo Cirrincione, Nadia Zaffaroni, Paola Barraja
A series of [1,2]Oxazolo [5,4-e]isoindoles has been synthesized through a versatile and high yielding sequence. All the new structures showed in the (1)HNMR spectra, the typical signal in the 8.34-8.47 ppm attributable to the H-3 of the [1,2]oxazole moiety. Among all derivatives, methoxy benzyl substituents at positions 3 and 4 or/and 5 were very effective in reducing the growth of different tumor cell lines, including diffuse malignant peritoneal mesothelioma (DMPM), an uncommon and rapidly malignancy poorly responsive to available therapeutic options...
September 5, 2016: European Journal of Medicinal Chemistry
Genta Kanai, Takatoshi Kakuta, Takashi Hirukawa, Chizuko Okamatsu, Masafumi Fukagawa
We report a case of peritoneal mesothelioma discovered in a patient during peritoneal dialysis. The patient was a 55-year-old woman who had no history of asbestos exposure. Owing to end-stage kidney failure, she had been undergoing peritoneal dialysis for over 8 years, and she had been diagnosed with encapsulating peritoneal sclerosis. She was admitted to the hospital for intestinal obstruction. Three months later, she noticed an enlarging mass in the epigastric region. Computed tomography showed a 10-cm mass originating in the abdominal wall that had invaded the liver...
2016: Tokai Journal of Experimental and Clinical Medicine
M D Llanos, P H Sugarbaker
BACKGROUND: A reasonable estimate is that 50% of patients treated with cytoreductive surgery (CRS) and perioperative chemotherapy for malignant peritoneal mesothelioma will recur. Recognition of this recurrence and knowledgeable selection for additional surgical intervention is important in improving survival of patients who progress. MATERIAL AND METHODS: Patients treated for malignant peritoneal mesothelioma with CRS and perioperative chemotherapy were placed in follow-up for assessment of symptoms and signs and radiologic abnormalities by CT...
August 26, 2016: European Journal of Surgical Oncology
François Huaux, Virginie d'Ursel de Bousies, Marie-Astrid Parent, Micaela Orsi, Francine Uwambayinema, Raynal Devosse, Saloua Ibouraadaten, Yousof Yakoub, Nadtha Panin, Mihaly Palmai-Pallag, Pierre van der Bruggen, Christian Bailly, Riccardo Marega, Etienne Marbaix, Dominique Lison
BACKGROUND: The asbestos-like toxicity of some engineered carbon nanotubes (CNT), notably their capacity to induce mesothelioma, is a serious cause of concern for public health. Here we show that carcinogenic CNT induce an early and sustained immunosuppressive response characterized by the accumulation of monocytic Myeloid Derived Suppressor Cells (M-MDSC) that counteract effective immune surveillance of tumor cells. METHODS: Wistar rats and C57BL/6 mice were intraperitoneally injected with carcinogenic multi-walled Mitsui-7 CNT (CNT-7) or crocidolite asbestos...
2016: Particle and Fibre Toxicology
Swati Khanna, Anish Thomas, Daniel Abate-Daga, Jingli Zhang, Betsy Morrow, Seth M Steinberg, Augusto Orlandi, Patrizia Ferroni, Jeffrey Schlom, Fiorella Guadagni, Raffit Hassan
INTRODUCTION: The functional aspects of programmed death 1 (PD-1) and PD ligand 1 (PD-L1) immune checkpoints in malignant mesothelioma have not been studied. METHODS: Tumor samples from 65 patients with mesothelioma were evaluated for PD-L1 expression by immunohistochemistry and its prognostic significance. Malignant effusions from patients with pleural and peritoneal mesothelioma were evaluated for PD-1(+) and PD-L1(+) infiltrating lymphocytes and their role in inducing tumor cell PD-L1 expression...
August 17, 2016: Journal of Thoracic Oncology
Pratyush Kumar, Kunal Chawla, Pooja Khosla, Sunil Jain
BACKGROUND: Tuberculosis is endemic in India and almost 40 % of the Indian population is infected with tubercle bacilli. Tuberculosis being a great mimicker of infectious as well as non infectious diseases and recent rise of multi drug resistant and extended drug resistant cases have made diagnosis and management more difficult. To the best of our knowledge there have been no reported cases of tuberculosis coexisting with malignant peritoneal mesothelioma leading to multiple site venous thrombosis...
2016: BMC Research Notes
Ashkan Salamatipour, Sanjay K Mohanty, Ralph A Pietrofesa, David R Vann, Melpo Christofidou-Solomidou, Jane K Willenbring
To measure the toxic potential of asbestos fibers-a known cause of asbestosis, lung cancer, and malignant mesothelioma-asbestos minerals are generally first ground down to small fibers, but it is unknown whether the grinding condition itself changes the fiber toxicity. To evaluate this, we ground chrysotile ore with or without water for 5-30 min and quantified asbestos-induced reactive oxygen species generation in elicited murine peritoneal macrophages as an indicator of fiber toxicity. The toxicity of dry-ground fibers was higher than the toxicity of wet-ground fibers...
July 12, 2016: Environmental Science & Technology Letters
Emel Canbay, Bahar Canbay Torun, Ege Sinan Torun, Yutaka Yonemura
Management of peritoneal surface malignancies has gradually evolved by the introduction of cytoreductive surgery in combination with intraperitoneal chemotherapy applications. Recently, peritoneal metastases of intraabdominal solid organ tumors and primary peritoneal malignancies such as peritoneal mesothelioma are being treated with this new approach. Selection criteria are important to reduce morbidity and mortality rates of patients who will experience minimal or no benefit from these combined treatment modalities...
2016: Ulusal Cerrahi Dergisi
Asuman Demiroglu-Zergeroglu, Emel Ergene, Nurettin Ayvali, Victor Kuete, Hulya Sivas
BACKGROUND: Malignant mesothelioma is a locally aggressive and highly lethal neoplasm of pleural, peritoneal and pericardial mesothelial cells without successful therapy. Previously, we reported that Quercetin in combination with Cisplatin inhibits cell proliferation and activates caspase-9 and -3 enzymes in different malignant mesothelioma cell lines. Moreover, Quercetin + Cisplatin lead to accumulation of both SPC111 and SPC212 cell lines in S phase. METHODS: In present work, 84 genes involved in cell growth and proliferation have analysed by using RT(2)-PCR array system and protein profile of mitogen activated protein kinase (MAPK) family proteins investigated by western blots...
2016: BMC Complementary and Alternative Medicine
Shumei Kato, Brett N Tomson, Timon P H Buys, Sheryl K Elkin, Jennifer L Carter, Razelle Kurzrock
Understanding the genomic landscape of malignant mesothelioma may identify novel molecular drivers of this ultra-rare disease, which can lead to an expanded roster of targeted therapies and clinical trial options for patients with mesothelioma. We examined the molecular profiles of 42 patients with malignant mesothelioma (including pleural, peritoneal, and pericardial) that were referred by clinicians to be tested in a Clinical Laboratory Improvement Amendments (CLIA) laboratory using next-generation sequencing (NGS; 182 or 236 genes)...
October 2016: Molecular Cancer Therapeutics
Alexandre Balaphas, Valentina Belfontali, Frédéric Ris, Andreas Lanitis, Raphael P H Meier, Marie-Laure Amram, Arnaud Roth, Olivier Huber, Thierry Berney, Philippe Morel
In 2016, peritoneal carcinomatosis can be considered as a chronic disease that can be treated and sometimes cured. Hyperthermic Intra PEritoneal Chemotherapy (HIPEC) is a procedure developed in the eighties. Combined with CytoReductive (CR) surgery, this protocol underwent a considerable expansion in Washington Cancer Institute. CR combined with HIPEC was demonstrated to be the only curative treatment for PseudoMyxoma Peritonei syndrome (PMP). It is actually approved in the management of peritoneal carcinomatosis of ovarian, colorectal, or peritoneal primitive (mesothelioma) origin but is still studied for gastric cancer...
June 15, 2016: Revue Médicale Suisse
Joshua C Leinwand, John A Chabot, Michael D Kluger
INTRODUCTION: Diffuse malignant peritoneal mesothelioma (DMPM) is an aggressive malignancy with a poor prognosis when treated with systemic therapy. Cytoreductive surgery (CRS) with intraperitoneal chemotherapy (IPC) is considered the best therapy in DMPM, but a high risk of locoregional recurrence remains. AREAS COVERED: This review describes patient selection and operative goals with CRS and IPC, the reported outcomes with this approach, and the data supporting platinum-based IPC...
September 2016: Expert Review of Anticancer Therapy
Kelly J Butnor, Elizabeth N Pavlisko, Thomas A Sporn, Victor L Roggli
AIMS: Mesothelial reaction simulating peritoneal diffuse malignant mesothelioma (MM) has been reported in the setting of Crohn ileitis. To our knowledge, peritoneal MM arising in patients with inflammatory bowel disease (IBD) has not been reported. The purpose of this study is to report the clinicopathological characteristics of patients with peritoneal MM and IBD. METHODS: A database of approximately 3800 MM was reviewed for cases of MM in patients with IBD. RESULTS: Three patients (0...
August 2, 2016: Journal of Clinical Pathology
V Kepenekian, D Elias, G Passot, E Mery, D Goere, D Delroeux, F Quenet, G Ferron, D Pezet, J M Guilloit, P Meeus, M Pocard, J M Bereder, K Abboud, C Arvieux, C Brigand, F Marchal, J M Classe, G Lorimier, C De Chaisemartin, F Guyon, P Mariani, P Ortega-Deballon, S Isaac, C Maurice, F N Gilly, O Glehen
PURPOSE: Diffuse malignant peritoneal mesothelioma (DMPM) is a severe disease with mainly locoregional evolution. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) is the reported treatment with the longest survival. The aim of this study was to evaluate the impact of perioperative systemic chemotherapy strategies on survival and postoperative outcomes in patients with DMPM treated with curative intent with CRS-HIPEC, using a multi-institutional database: the French RENAPE network...
September 2016: European Journal of Cancer
Enrico Pira, Canzio Romano, Francesco S Violante, Andrea Farioli, Giovanna Spatari, Carlo La Vecchia, Paolo Boffetta
Limited information is available on risk of peritoneal mesothelioma after asbestos exposure, and in general on the risk of cancer after cessation of asbestos exposure. We updated to 2013 the follow-up of a cohort of 1083 female and 894 male textile workers with heavy asbestos exposure (up to 100 fb/mL), often for short periods. A total of 1019 deaths were observed, corresponding to a standardized mortality ratio (SMR) of 1.68 (95% confidence interval [CI]: 1.57-1.78). SMRs were 29.1 (95% CI: 21.5-38.6) for peritoneal cancer, 2...
September 2016: Cancer Medicine
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