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peritoneal mesothelioma

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https://www.readbyqxmd.com/read/29651664/the-impact-of-chemotherapy-and-its-timing-on-survival-in-malignant-peritoneal-mesothelioma-treated-with-complete-debulking
#1
Samer A Naffouje, Kiara A Tulla, George I Salti
The current standard of treatment for malignant peritoneal mesothelioma (MPM) is cytoreductive surgery when the disease distribution is favorable. The role of chemotherapy, as an adjunct to surgery, remains unclear. The national database of mesothelioma was used to identify MPM patients who were treated with curative intent. Patients were divided into treatment groups: (1) chemotherapy only, (2) surgery only, (3) neoadjuvant chemotherapy + surgery, and (4) surgery + adjuvant chemotherapy. A negative control group of patients who did not receive any treatment was added (group 0)...
April 12, 2018: Medical Oncology
https://www.readbyqxmd.com/read/29651643/splenosis-a-great-mimicker-of-neoplastic-disease
#2
REVIEW
Yasmeen K Tandon, Christopher P Coppa, Andrei S Purysko
Splenosis is a benign condition that can occur after splenic trauma or after surgery involving the spleen. These splenic implants are most often seen within the abdominal and pelvic cavities. On imaging, splenosis can be confused with multiple additional entities including metastatic disease, peritoneal carcinomatosis, peritoneal mesothelioma, abdominal lymphoma, renal cancer, hepatic adenomas, or endometriosis depending on its distribution. In all patients with history of splenic surgery or trauma, splenosis should be on the differential diagnosis of soft tissue nodules in the abdomen and pelvis, especially in the absence of systemic symptoms, to avoid unnecessary biopsy, chemotherapy, or surgery...
April 12, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29650903/-diffuse-malignant-peritoneal-mesothelioma-with-secondary-liver-invasion-diagnosed-using-laparoscopy-a-case-report
#3
Hiroshi Yasuda, Satoshi Okumura, Shou Toyoda, Kansuke Yamamoto, Naoto Mizumura, Aya Itou, Masao Ogawa, Masayasu Kawasaki, Masao Kameyama
A 69-year-old man with right upper quadrant abdominal pain and fever was referred to our hospital. He had a history of asbestosis exposure. Computed tomography(CT)revealed a mass at the right subhepatic space, and an antibiotic was administered after a diagnosis of an abdominal abscess. However, the patient did not respond to the treatment, and finally, exploratory laparoscopy was performed. A sheet of combined white nodules surrounding the right lobe of the liver was found, and the mass was continuous with the covering particles...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29643915/prognostic-significance-of-blood-serum-and-ascites-parameters-in-patients-with-malignant-peritoneal-mesothelioma-or-peritoneal-carcinomatosis
#4
Shan-Shan Su, Guo-Qi Zheng, Wen-Jie Yin, Yu-Fei Liang, Ying-Ying Liu, Hui Song, Ning-Ning Sun, Yu-Xin Yang
To determine effects of the biochemical and cytological properties of blood, serum, and ascites on survival of patients with malignant peritoneal effusion (MPeE), including malignant peritoneal mesothelioma (MPeM) and peritoneal carcinomatosis (PC), we conducted a retrospective study of patients with MPeE and healthy controls. Potential prognostic factors were identified as follows: age, sex, blood neutrophil-to-lymphocyte ratio (NLR), serum parameters, ascites parameters, serum-ascites albumin gradient, and the ascites-serum LDH ratio...
2018: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/29589675/cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-risk-factors-for-morbidity-and-postoperative-outcome
#5
Manuela Robella, Marco Vaira, Armando Cinquegrana, Alice Borsano, Michele DE Simone
BACKGROUND: Cytoreductive surgery (CRS) followed by hyperthermic intraperitoneal chemotherapy (HIPEC) represents a treatment option for peritoneal surface malignancies. Even if it has been reported that this new approach improved survival of selected patients, it's still associated with high morbidity and mortality rates. METHODS: From October 1995 to December 2017, over 450 patients patients affected by peritoneal carcinomatosis (PC) underwent in our Institute to CRS associated with HIPEC...
March 28, 2018: Minerva Chirurgica
https://www.readbyqxmd.com/read/29588242/primary-spinal-malignant-mesothelioma-a-case-report-and-literature-review
#6
Fan Chen, Beifang Liu, Ying Yu, Jianyang Du, Dawei Chen
BACKGROUND: Malignant mesotheliomas are aggressive and rapidly-fatal neoplasms arising from the mesothelial cells. The most common sites of origin are the pleural and peritoneal cavities, and additionally, malignant mesotheliomas can also infrequently involve the pericardium and the tunica vaginalis. However, malignant mesothelioma occurring in the spinal canal is extremely rare. Herein, we reported a case with primary spinal malignant mesothelioma. METHODS: A literature search was using PubMed with specific key terms, inclusion criteria, and exclusion criteria...
March 24, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29582708/peritoneal-and-scrotal-carcinomas-of-unknown-origin-in-two-bovine-calves
#7
Kelsey A Brakel, Grace VanHoy, Austin Hinds, Justin Breitbach, Christopher Premanandan, Rebecca Kohnken
Two unrelated bovine beef calves, aged 2 mo and 3 mo, were presented to The Ohio State University Veterinary Medical Center because of scrotal swelling and abdominal distension. On postmortem examination, there was abundant peritoneal fluid and numerous small friable masses covering all peritoneal surfaces and extending into the scrotum via the tunica vaginalis, with no identifiable primary neoplasm. Based on light microscopy, differential diagnoses included malignant mesothelioma and anaplastic carcinoma. Immunohistochemically, the neoplasms labeled positive for cytokeratin, and negative for vimentin and calretinin...
March 1, 2018: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/29577057/malignant-peritoneal-mesothelioma-presenting-as-mucinous-ascites
#8
Zachary Field, Andreas Zori, Vikas Khullar, Manoela Mota, Michael Feely, Roberto J Firpi
We present a rare case of a 46-year-old man presenting with mucinous ascites secondary to malignant peritoneal mesothelioma (MPM) that was diagnosed via colonoscopy with biopsies. Both our findings and the clinical presentation were unique. While it is widely known that asbestos exposure is commonly associated with pleural mesothelioma, 6-10% of malignant mesotheliomas arise from the peritoneum. To date, only 4 cases of MPM with the primary tumor site in the colon have been described in the literature.
2018: ACG Case Reports Journal
https://www.readbyqxmd.com/read/29565815/targeting-the-hippo-pathway-is-a-new-potential-therapeutic-modality-for-malignant-mesothelioma
#9
REVIEW
Yoshitaka Sekido
Malignant mesothelioma (MM) constitutes a very aggressive tumor that arises from the pleural or peritoneal cavities and is highly refractory to conventional therapies. Several key genetic alterations are associated with the development and progression of MM including mutations of the CDKN2A/ARF , NF2 , and BAP1 tumor-suppressor genes. Notably, activating oncogene mutations are very rare; thus, it is difficult to develop effective inhibitors to treat MM. The NF2 gene encodes merlin, a protein that regulates multiple cell-signaling cascades including the Hippo pathway...
March 22, 2018: Cancers
https://www.readbyqxmd.com/read/29534357/-value-of-immunocytochemistry-in-differential-diagnosis-of-gastric-adenocarcinoma-reactive-mesothelial-cells-and-malignant-epithelial-mesothelioma-in-metastatic-effusion-fluid
#10
M Lyu, N Cha, Y F Zou, J H Leng, L Xu, Y Sun, Y Y Hao
Objective: To investigate the diagnostic value of some antibodies in peritoneal fluid of patients with gastric cancer and malignant epithelioid mesothelioma in serous effusion. Methods: One hundred and eighty-two cases of serous effusion were collected at Jilin Cancer Hospital, from July 2012 to July 2016. The expression of GLUT1, CDX2, Villin, calretinin and WT1 was evaluated using SP immunocytochemical technique in peritoneal fluid samples collected from 98 patients with gastric cancer and 74 patients with reactive mesothelial cells...
March 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29518763/medullary-thyroid-cancer-leukemia-mesothelioma-and-meningioma-associated-with-germline-apc-and-rasal1-variants-a-new-syndrome
#11
Anna Angelousi, Nikolaos Settas, Fabio R Faucz, Charalampos Lyssikatos, Martha Quezado, Narjes Nasiri-Ansari, Constantine A Stratakis, Eva Kassi
Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor hereditary in 35% of cases. The most common syndromic form is in the context of the multiple endocrine neoplasia type 2 (MEN 2) syndromes in association with other tumors and due to germline RET mutations. We describe a 57-year-old female patient diagnosed with sporadic MTC. The patient had a history of other neoplasias, such as acute myeloid leukemia, for which she had received chemotherapy, and two other solid tumors, peritoneal mesothelioma and meningioma...
October 2017: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29511797/benign-multicystic-mesothelioma-and-peritoneal-inclusion-cysts-are-they-the-same-clinical-and-histopathological-entities-a-systematic-review-to-find-an-evidence-based-management
#12
REVIEW
Agnese Maria Chiara Rapisarda, Antonio Cianci, Salvatore Caruso, Salvatore Giovanni Vitale, Gaetano Valenti, Eliana Piombino, Stefano Cianci
PURPOSE: Peritoneal mesothelial cysts (PMC) are a clinical dilemma because of their true pathogenic nature. Many definitions have been associated with PMC, including "benign multicystic mesothelioma", "cystic mesothelioma", "multilocular peritoneal inclusion cysts", ''inflammatory cysts of the peritoneum" or "postoperative peritoneal cyst". METHODS: We herein performed a systematic review of the literature focusing on clinical and histopathological aspects of PMC, diagnosis, and therapies...
March 6, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29507787/physicochemical-and-pharmacokinetic-properties-of-polymeric-films-loaded-with-cisplatin-for-the-treatment-of-malignant-pleural-mesothelioma
#13
Fabio Sonvico, Stefano Barbieri, Paolo Colombo, Claudio Mucchino, Elisabetta Barocelli, Anna Maria Cantoni, Andrea Cavazzoni, Pier Giorgio Petronini, Michele Rusca, Paolo Carbognani, Luca Ampollini
Background: Malignant mesothelioma is an invasive neoplasm arising from mesothelial surfaces of the pleural and peritoneal cavities. Mesothelioma treatment is unsatisfactory and recurrence is common. Here an innovative locoregional treatment for malignant pleural mesothelioma is presented. Methods: Chitosan- and hyaluronate-based films were loaded with 0.5% and 4% w/w cisplatin and were studied for their physicochemical, mechanical and drug release characteristics...
January 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29507420/how-asbestos-drives-the-tissue-towards-tumors-yap-activation-macrophage-and-mesothelial-precursor-recruitment-rna-editing-and-somatic-mutations
#14
Hubert Rehrauer, Licun Wu, Walter Blum, Lazslo Pecze, Thomas Henzi, Véronique Serre-Beinier, Catherine Aquino, Bart Vrugt, Marc de Perrot, Beat Schwaller, Emanuela Felley-Bosco
Chronic exposure to intraperitoneal asbestos triggered a marked response in the mesothelium well before tumor development. Macrophages, mesothelial precursor cells, cytokines, and growth factors accumulated in the peritoneal lavage. Transcriptome profiling revealed YAP/TAZ activation in inflamed mesothelium with further activation in tumors, paralleled by increased levels of cells with nuclear YAP/TAZ. Arg1 was one of the highest upregulated genes in inflamed tissue and tumor. Inflamed tissue showed increased levels of single-nucleotide variations, with an RNA-editing signature, which were even higher in the tumor samples...
March 6, 2018: Oncogene
https://www.readbyqxmd.com/read/29506546/analysis-of-prognostic-factors-of-patients-with-malignant-peritoneal-mesothelioma
#15
Wenjie Yin, Guoqi Zheng, Kunna Yang, Hui Song, Yufei Liang
BACKGROUND: The study aims to find out independent prognostic factors for patients with malignant peritoneal mesothelioma (MPeM). METHODS: Patients with pathologically proven MPeM were retrospectively reviewed. Potential prognostic factors were analyzed, including age, gender, asbestos exposure, body mass index (BMI), treatment, and laboratory results, such as blood routine examination and liver functions. The influences of various risk factors on the prognoses were analyzed by univariate analysis...
March 5, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29503128/mesothelin-and-osteopontin-as-circulating-markers-of-diffuse-malignant-peritoneal-mesothelioma-a-preliminary-study
#16
Federica Bruno, Dario Baratti, Antonia Martinetti, Daniele Morelli, Elisa Sottotetti, Chiara Bonini, Marcello Guaglio, Shigeki Kusamura, Marcello Deraco
BACKGROUND: The differential diagnosis between diffuse malignant peritoneal mesothelioma (DMPM) and other peritoneal surface malignancies (PSM) is still challenging. Serum mesothelin and osteopontin are increasingly used as markers of pleural mesothelioma, but their role in DMPM is unclear. We assessed the diagnostic and prognostic values of mesothelin, osteopontin, CEA, CA19.9, CA125, and CA15.3 in DMPM patients. METHODS: Markers were dosed before cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) by enzyme-linked immunosorbent assay (ELISA) in 30 DMPM patients and 14 controls with other PSMs...
February 17, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29480760/malignant-mesothelioma-and-its-non-asbestos-causes
#17
Richard L Attanoos, Andrew Churg, Francoise Galateau-Salle, Allen R Gibbs, Victor L Roggli
CONTEXT: - Although many mesotheliomas are related to asbestos exposure, not all are, and there is increasing information on other causes of mesothelioma. OBJECTIVE: - To provide a review of non-asbestos causes for malignant mesothelioma. DATA SOURCES: - Review of relevant literature published via PubMed and other search engines. CONCLUSIONS: - Currently, most pleural mesotheliomas (70% to 90%) in men in Europe and North America are attributable to asbestos exposure; for peritoneal mesothelioma the proportion is lower...
February 26, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29475412/urological-approach-for-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-in-a-clinical-care-center
#18
Carlos Gustavo Trujillo, Cristina Domínguez, Daniela Robledo, Juan Ignacio Caicedo, Alejandra Bravo-Balado, Juan Guillermo Cataño, Natalia Cortés, Lina Parra, Wilson Riaño, Eduardo Londoño-Schimmer, Jorge Otero, Gabriel Herrera, Fernando Arias, Mauricio Plata
BACKGROUND: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) is associated with significant manipulation of the urinary tract (UT). We aim to describe the urological events and their management in patients who underwent CRS-HIPEC. METHODS: Clinical records of patients who underwent treatment between 2007 and 2015 were reviewed. Urological events and their multidisciplinary management were analyzed. Descriptive statistics were calculated...
February 23, 2018: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/29462558/molecular-imaging-of-mesothelin-expressing-ovarian-cancer-with-a-human-and-mouse-cross-reactive-nanobody
#19
Andrew M Prantner, Catherine Yin, Kalika Kamat, Khushboo Sharma, Andrew C Lowenthal, Peter Bawden Madrid, Nathalie Scholler
Mesothelin is an epithelial marker highly expressed at the cell surface of cancer cells from diverse origins, including ovarian and pancreatic adenocarcinomas and mesotheliomas. Previously, we identified and characterized an anti-mesothelin nanobody (NbG3a) for in vitro diagnostic applications. The main goal of this research was to establish the potential of NbG3a as a molecular imaging agent. Site-specific biotinylated NbG3a (bNbG3a) was bound to streptavidin-conjugated reagents for in vitro and in vivo assays...
February 20, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29435293/a-case-of-peritoneal-malignant-mesothelioma-following-radiation-therapy-for-cervical-cancer
#20
Mitsutake Yano, Yuji Ikeda, Tomomi Kato, Mika Sakaki, Sho Sato, Akira Yabuno, Eito Kozawa, Masanori Yasuda
The present study presents a case of peritoneal malignant mesothelioma (PMM) following radiation therapy for cervical cancer. A 34-year-old Japanese woman, without asbestos exposure, was referred to the Department of Gynecologic Oncology, Saitama Medical University International Medical Center due to a cervical mass, and was diagnosed with cervical squamous cell carcinoma (SCC). The serum levels of tumor markers, including SCC antigen and cancer antigen 125 (CA125) were 229.0 ng/ml and 54.4 U/ml, respectively...
February 2018: Molecular and Clinical Oncology
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