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Procyanidin

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https://www.readbyqxmd.com/read/28317766/first-evidences-of-interaction-between-pyranoanthocyanins-and-salivary-proline-rich-proteins
#1
Ignacio García-Estévez, Luís Cruz, Joana Oliveira, Nuno Mateus, Victor de Freitas, Susana Soares
The contribution of other classes of polyphenol compounds besides tannins to the overall perception of astringency is still poorly understood. So, this work aimed to study the interaction between a family of salivary proline-rich proteins (aPRPs) and representative pyranoanthocyanins in red wines [pyranomalvidin-3-glucoside (vitisin B), pyranomalvidin-3-glucoside-catechol, and pyranomalvidin-3-glucoside-epicatechin] using saturation transfer difference-NMR and MALDI-TOF. For vitisin B KD was of 1.74mM; for pyranomalvidin-3-glucoside-catechol was 1...
August 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28317744/molecular-study-of-mucin-procyanidin-interaction-by-fluorescence-quenching-and-saturation-transfer-difference-std-nmr
#2
Elsa Brandão, Mafalda Santos Silva, Ignacio García-Estévez, Nuno Mateus, Victor de Freitas, Susana Soares
Astringency is closely related to the interaction between procyanidins and salivary proteins (SP). The aim of this work was to study the interaction between mucin, a SP responsible for saliva lubricating properties, with different procyanidins (B4 dimer, tetramer (TT) and fractions of oligomeric procyanidins), and the influence of several conditions [pH, ionic strength, procyanidins' mean degree of polymerization (mDP) and different solvents (ethanol or dimethylsulfoxide)] on this interaction by fluorescence quenching and Saturation Transfer Difference (STD)-NMR...
August 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28314100/attenuated-mtor-signaling-and-enhanced-glucose-homeostasis-by-dietary-supplementation-with-lotus-seedpod-oligomeric-procyanidins-in-streptozotocin-stz-induced-diabetic-mice
#3
Xiaopeng Li, Yong Sui, Qian Wu, Bijun Xie, Zhida Sun
This study investigated the protective role of lotus seedpod oligomeric procyanidins (LSOPC) and synbiotics (Bifidobacterium Bb-12 and xylo-oligosaccharide) against high fat and streptozotocin (STZ)-induced diabetes. Administration of LSOPC or synbiotics have no effect on blood glucose in normal mice. Treatments with LSOPC for 12 weeks markedly reduced blood glucose, FFA, endotoxin, GHbA1c and improved glucose homeostasis, lipid metabolism and insulin level. In addition, administration of LSOPC significantly reversed the increase of mTOR and p66Shc in liver, skeletal muscle and white adipose tissue (WAT)...
March 17, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28303711/phenolic-elderberry-extracts-anthocyanins-procyanidins-and-metabolites-influence-glucose-and-fatty-acid-uptake-in-human-skeletal-muscle-cells
#4
Giang Thanh Thi Ho, Eili Tranheim Kase, Helle Wangensteen, Hilde Barsett
The uptake of glucose and fatty acids in skeletal muscle is of interest for type 2 diabetes treatment. The aim was to study glucose and fatty acid uptake in skeletal muscle cells, antioxidant effects and inhibition of carbohydrate-hydrolyzing enzymes by elderberries. Enhanced glucose and oleic acid uptake in human skeletal muscle cells were observed after treatment with phenolic elderberry extracts, anthocyanins, procyanidins and their metabolites. The 96% EtOH and the acidified MeOH extracts were highly active...
March 17, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28282861/elderberry-and-elderflower-extracts-phenolic-compounds-and-metabolites-and-their-effect-on-complement-raw-264-7-macrophages-and-dendritic-cells
#5
Giang Thanh Thi Ho, Helle Wangensteen, Hilde Barsett
Modulation of complement activity and inhibition of nitric oxide (NO) production by macrophages and dendritic cells may have therapeutic value in inflammatory diseases. Elderberry and elderflower extracts, constituents, and metabolites were investigated for their effects on the complement system, and on NO production in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages and murine dendritic D2SC/I cells. The EtOH crude extracts from elderberry and elderflower and the isolated anthocyanins and procyanidins possessed strong complement fixating activity and strong inhibitory activity on NO production in RAW cells and dendritic cells...
March 8, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28274120/differences-in-vvufgt-and-vvmyba1-gene-expression-levels-and-phenolic-composition-in-table-grape-vitis-vinifera-l-red-globe-and-its-somaclonal-variant-pink-globe
#6
Luis Bustamante, Vania Saez, Patricio Hinrichsen, Maria H Castro, Carola Vergara, Dietrich Von Baer, Claudia Mardones
A novel 'Red Globe' (RG)-derived grape variety, 'Pink Globe' (PG), was described and registered as a new genotype, with earlier ripening and sweeter taste than that of RG. Microsatellite analysis revealed that PG and RG are undifferentiable; however, the PG VvmybA1c contains six SNPs within the coding and non-coding region, possible related to the reduced VvmybA1 expression levels. Conversely, HPLC-DAD-ESI-MS/MS analysis showed significantly lower anthocyanin content in PG skin than in RG skin and PG had no detectable trihydroxylated anthocyanins...
March 8, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28264525/occurrence-and-antioxidant-activity-of-c1-degradation-products-in-cocoa
#7
Cédric De Taeye, Marie-Lucie Kankolongo Cibaka, Sonia Collin
Procyanidin C1 is by far the main flavan-3-ol trimer in cocoa. Like other flavan-3-ols, however, it suffers a lot during heat treatments such as roasting. RP-HPLCHRMS/MS(ESI(-))analysis applied to an aqueous model medium containing commercial procyanidin C1 proved that epimerization is the main reaction involved in its degradation (accounting for 62% of degradation products). In addition to depolymerization, cocoa procyanidin C1 also proved sensitive to oxidation, yielding once- and twice-oxidized dimers. No chemical oligomer involving the native trimer was found in either model medium or cocoa, while two C1 isomers were retrieved...
February 28, 2017: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28260647/a-lipidomic-study-on-the-regulation-of-inflammation-and-oxidative-stress-targeted-by-marine-%C3%AF-3-pufa-and-polyphenols-in-high-fat-high-sucrose-diets
#8
Gabriel Dasilva, Manuel Pazos, Eduardo García-Egido, José M Gallardo, Sara Ramos-Romero, Josep Lluís Torres, Marta Romeu, María-Rosa Nogués, Isabel Medina
The ability of polyphenols to ameliorate potential oxidative damage of ω-3 PUFAs when they are consumed together and then, to enhance their potentially individual effects on metabolic health is discussed through the modulation of fatty acids profiling and the production of lipid mediators. For that, the effects of the combined consumption of fish oils and grape seed procyanidins on the inflammatory response and redox unbalance triggered by high-fat high-sucrose (HFHS) diets were studied in an animal model of Wistar rats...
February 21, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28242910/effect-of-mixing-different-kinds-of-fruit-juice-with-sour-cherry-puree-on-nutritional-properties
#9
Paulina Nowicka, Aneta Wojdyło, Mirosława Teleszko
The main objective of this study was to investigate the effect of mixing sour cherry puree with apple, pear, quince and flowering quince juices on characteristics of 17 different products (12 smoothies and 5 semi-products). Compounds (phenolic compounds, vitamin C, sugar, pectin), antioxidant activity (ORAC, ABTS, FRAP), and physicochemical parameters (titratable acidity, soluble solids, viscosity, colour) of different products were evaluated. Depending on the type of product, 8 to 20 phenolic compounds, belonging to the anthocyanins, flavan-3-ols, flavonols, hydroxycinnamic acids, and dihydrochalcone, were identified by liquid chromatography/quadrupole time-of-flight mass spectrometry (LC/QTOF-MS)...
January 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28239840/melasma-systematic-review-of-the-systemic-treatments
#10
REVIEW
Linghong Linda Zhou, Akerke Baibergenova
Currently available treatment options for melasma include prevention of UV radiation, topical lightening agents, chemical peels, and light-based and laser therapies. However, none have shown effective and sustained results, with incomplete clearance and frequent recurrences. There has been increasing interest recently in oral medications and dietary supplements in improving melasma. We sought to evaluate the efficacy and safety/tolerability of oral medications and dietary supplements for the treatment of melasma...
February 27, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28211563/cytotoxic-analysis-and-chemical-characterization-of-fractions-of-the-hydroalcoholic-extract-of-the-euterpe-oleracea-mart-seed-in-the-mcf-7-cell-line
#11
Dayanne da S Freitas, José A Morgado-Díaz, Adriana S Gehren, Flávia C B Vidal, Raquel Maria T Fernandes, Wanderson Romão, Lilian V Tose, Fabiola N S Frazão, Maria Célia P Costa, Dulcelena F Silva, Maria do Desterro S B Nascimento
OBJECTIVES: To analyse the antineoplastic activity of fractions derived from the hydroalcoholic extract of Euterpe oleracea Mart. seed in the MCF-7 cell line and to identify the compounds responsible for the antineoplastic action. METHODS: Cells were treated with 10, 20, 40 and 60 μg/ml with the hexane, chloroform and ethyl acetate fraction (EAF) of the hydroalcoholic extract of açaí seed, for 24 and 48 h. After treatment, cell viability was measured using MTT assay and cell death was assessed using the Annexin-Pi assay...
February 17, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28207258/procyanidin-a2-and-its-degradation-products-in-raw-fermented-and-roasted-cocoa
#12
Cédric De Taeye, Gilles Caullet, Victor Jos Eyamo Evina, Sonia Collin
Cocoa is known as an important source of flavan-3-ols, but their fate "from the bean to the bar" is not yet clear. Here, procyanidin A2 found in native cocoa beans (9-13 mg/kg) appeared partially epimerized into A2(E1) through fermentation, whereas a second epimer (A2(E2)) emerged after roasting. At m/z 575, dehydrodiepicatechin A was revealed to be the major HPLC peak before fermentation, whereas F1, a marker of well-conducted fermentations, becomes the most intense after roasting. RP-HPLC-ESI(-)-HRMS/MS analysis performed on a procyanidin A2 model medium after 12 h at 90 °C revealed many more degradation products than those identified in fermented cocoa, including the last epimer of A2, A2 open structure intermediates (m/z 577), and oxidized A-type dimers (m/z 573)...
February 16, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28196336/regression-of-atherosclerosis-with-apple-procyanidins-by-activating-the-atp-binding-cassette-subfamily-a-member-1-in-a-rabbit-model
#13
Liang Wang, Toshio Fumoto, Saeko Masumoto, Toshihiko Shoji, Tomisato Miura, Masato Naraoka, Naoya Matsuda, Tadaatsu Imaizumi, Hiroki Ohkuma
BACKGROUND AND AIMS: Apple polyphenol contains abundant procyanidins, which have been associated with an anti-atherosclerosis and cholesterol-lowering effect. The aim of this study was to investigate whether apple procyanidins (APCs) feature therapeutic efficacy in terms of regressing atherosclerosis and whether this efficacy is due to mechanisms other than a cholesterol-lowering effect. METHODS: After eight weeks on an atherogenic diet, rabbits were given a normal diet for another eight weeks to normalize the increased serum lipids level...
March 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28195469/effect-of-the-a-type-linkage-on-the-pharmacokinetics-and-intestinal-metabolism-of-litchi-pericarp-oligomeric-procyanidins
#14
Shuyi Li, Yang Liu, Gang Liu, Jingren He, Xinguang Qin, Haochen Yang, Zhongze Hu, Olusola Lamikanra
The bioavailability of A-type procyanidins in vivo has been rarely investigated; as such, this study discusses the effect of A-type linkage and degree of polymerization on the metabolism of procyanidins extracted from litchi pericarp (LPOPC). Sprague-Dawley rats were gavaged with (-)-epicatechin (EC) and LPOPC and sacrificed at different time points after ingestion. A-type linkage procyanidin oligomers inhibited the absorption of EC. Analysis of urinary contents from rats administered with EC, A-type procyanidin dimer (A-2), and A-type procyanidin trimer (A-3) showed distinct native and metabolite profiles for each rat...
February 23, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28189068/passiflora-tarminiana-fruits-reduce-uvb-induced-photoaging-in-human-skin-fibroblasts
#15
Karent Bravo, Luisa Duque, Federico Ferreres, Diego A Moreno, Edison Osorio
Skin aging is a complex process that is strongly affected by UV radiation, which stimulates the production of reactive oxygen species (ROS) in the epidermis and dermis and subsequently causes skin damage. Among the major consequences are increased collagen degradation and reduced collagen synthesis. Previous reports have demonstrated the beneficial effects of polyphenols for healthy skin. Passiflora tarminiana Coppens & V.E. Barney, a species of the Passifloraceae family, is widely distributed in South America and is rich in flavonoids...
February 3, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28188424/fine-tuning-of-the-flavonoid-and-monolignol-pathways-during-apple-early-fruit-development
#16
Paolo Baldi, Mirko Moser, Matteo Brilli, Urska Vrhovsek, Massimo Pindo, Azeddine Si-Ammour
A coordinated regulation of different branches of the flavonoid pathway was highlighted that may contribute to elucidate the role of this important class of compounds during the early stages of apple fruit development. Apple (Malus × domestica Borkh.) is an economically important fruit appreciated for its organoleptic characteristics and its benefits for human health. The first stages after fruit set represent a very important and still poorly characterized developmental process. To enable the profiling of genes involved in apple early fruit development, we combined the suppression subtractive hybridization (SSH) protocol to next-generation sequencing...
February 11, 2017: Planta
https://www.readbyqxmd.com/read/28182841/bioactive-components-and-antioxidant-capacity-of-fruits-from-nine-sorbus-genotypes
#17
Maja Mikulic-Petkovsek, Boris Krska, Biljana Kiprovski, Robert Veberic
In this study, biochemical profile of fruits of 9 Sorbus genotypes was analyzed. The content of total sugars ranged from 69.7 g/kg ('Titan') to 217.5 g/kg (Sorbus torminalis) and total organic acids from 17.7 g/kg ('Businka') to 40.2 g/kg (S. torminalis). The highest content of total anthocyanins had 'Burka' (871 mg/kg FW) and 'Businka' (856 mg/kg FW). Quercetin derivatives represented more than 95% of total flavonols. 'Alaja krupnaja' had 3.5- to 29-fold higher rutin content than other analyzed genotypes. S...
February 9, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28178683/gspe-reduces-lead-induced-oxidative-stress-by-activating-the-nrf2-pathway-and-suppressing-mir153-and-gsk-3%C3%AE-in-rat-kidney
#18
Biying Liu, Haili Zhang, Xiao Tan, Daqian Yang, Zhanjun Lv, Huijie Jiang, Jingjing Lu, Ruiqi Baiyun, Zhigang Zhang
Lead (Pb) is a global environmental health hazard that leads to nephrotoxicity. However, the effective treatment of Pb-induced nephrotoxicity remains elusive. Grape seed procyanidin extract (GSPE) has beneficial properties for multiple biological functions. Therefore, the present study investigated whether GSPE reduced Pb-induced nephrotoxicity as well as the protective mechanism of GSPE in a well-established 35-day Pb induced nephrotoxicity rat model. The results showed that GSPE normalized Pb-induced oxidative stress, histological damage, inflammatory, apoptosis, and changes of miR153 and glycogen synthase kinase 3β (GSK-3β) levels in rat kidney...
February 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28178632/impact-of-bioaccessibility-and-bioavailability-of-phenolic-compounds-in-biological-systems-upon-the-antioxidant-activity-of-the-ethanolic-extract-of-triplaris-gardneriana-seeds
#19
José Joaquim Lopes Neto, Thiago Silva de Almeida, Jackeline Lima de Medeiros, Leonardo Rogério Vieira, Thaís Borges Moreira, Ana Isabel Vitorino Maia, Paulo Riceli Vasconcelos Ribeiro, Edy Sousa de Brito, Davi Felipe Farias, Ana Fontenele Urano Carvalho
The most studied bioactive potential of phenolic compounds corresponds to antioxidant activity, which in turn, is associated with a reduction in the incidence of various human diseases. However, the total quantity of these bioactive substances in foods and medicinal preparations does not reflect the amount absorbed and metabolized by the body. The present study aimed to investigate the bioaccessibility of Triplaris gardneriana seeds ethanolic extract (EETg) by determination of phenolic composition and antioxidant activities before and after in vitro digestion as well as to estimate its bioavailability by chemical analysis of plasma and urine in animal models after oral administration...
April 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28165396/proanthocyanidin-characterization-and-bioactivity-of-extracts-from-different-parts-of-uncaria-tomentosa-l-cat-s-claw
#20
Mirtha Navarro-Hoyos, Rosa Lebrón-Aguilar, Jesús E Quintanilla-López, Carolina Cueva, David Hevia, Silvia Quesada, Gabriela Azofeifa, M Victoria Moreno-Arribas, María Monagas, Begoña Bartolomé
Apart from alkaloids, bioactive properties of Uncaria tomentosa L. have been attributed to its phenolic constituents. Although there are some reports concerning low-molecular-weight polyphenols in U. tomentosa, its polymeric phenolic composition has been scarcely studied. In this study, phenolic-rich extracts from leaves, stems, bark and wood (n = 14) of Uncaria tomentosa plants from several regions of Costa Rica were obtained and analysed in respect to their proanthocyanidin profile determined by a quadrupole-time-of-flight analyser (ESI-QTOF MS)...
February 4, 2017: Antioxidants (Basel, Switzerland)
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