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Procyanidin

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https://www.readbyqxmd.com/read/27896020/identification-of-phenolic-secondary-metabolites-from-schotia-brachypetala-sond-fabaceae-and-demonstration-of-their-antioxidant-activities-in-caenorhabditis-elegans
#1
Mansour Sobeh, Esraa ElHawary, Herbenya Peixoto, Rola M Labib, Heba Handoussa, Noha Swilam, Ahmed H El-Khatib, Farukh Sharapov, Tamer Mohamed, Sonja Krstin, Michael W Linscheid, Abdel Nasser Singab, Michael Wink, Nahla Ayoub
BACKGROUND: Schotia brachypetala Sond. (Fabaceae) is an endemic tree of Southern Africa whose phytochemistry and pharmacology were slightly studied. The present work aimed at profiling the major phenolics compounds present in the hydro-alcohol extract from S. brachypetala leaves (SBE) using LC/HRESI/MS/MS and NMR and prove their antioxidant capabilities using novel methods. METHODS: In vitro assays; DPPH, TEAC persulfate decolorizing kinetic and FRAP assays, and in vivo assays: Caenorhabditis elegans strains maintenance, Intracellular ROS in C...
2016: PeerJ
https://www.readbyqxmd.com/read/27855899/phenolic-compounds-extracted-by-acidic-aqueous-ethanol-from-berries-and-leaves-of-different-berry-plants
#2
Ye Tian, Jaana Liimatainen, Aino-Liisa Alanne, Anni Lindstedt, Pengzhan Liu, Jari Sinkkonen, Heikki Kallio, Baoru Yang
Phenolic compounds of berries and leaves of thirteen various plant species were extracted with aqueous ethanol and analyzed with UPLC-DAD-ESI-MS, HPLC-DAD, and NMR. The total content of phenolics was consistently higher in leaves than in berries (25-7856 vs. 28-711mg/100g fresh weight). Sea buckthorn leaves were richest in phenolic compounds (7856mg/100g f.w.) with ellagitannins as the dominant compound class. Sea buckthorn berries contained mostly isorhamnetin glycosides, whereas quercetin glycosides were typically abundant in most samples investigated...
April 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27845756/the-use-of-grape-seed-byproducts-rich-in-flavonoids-to-improve-the-antioxidant-potential-of-red-wines
#3
María José Jara-Palacios, Dolores Hernanz, María Luisa Escudero-Gilete, Francisco J Heredia
The influence of adding seeds from grape pomace during Syrah wine fermentation in a warm climate has been studied. Seeds of Pedro Ximenez variety were rich in phenolic compounds, mainly flavonoids such as catechin and procyanidins. Changes in total phenolic content (TPC), total flavonoid content (TFC), and antioxidant activity of red wines were observed. These changes depended on the vinification stage and the amount of seeds (SW: 450 g or DW: 900 g seeds/150 kg grapes) applied. In general, antioxidant activity was greater when a simple dose (SW) was considered...
November 12, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27845745/procyanidin-a2-modulates-il-4-induced-ccl26-production-in-human-alveolar-epithelial-cells
#4
Sara L Coleman, Marlena C Kruger, Gregory M Sawyer, Roger D Hurst
Allergic asthma is an inflammatory lung disease that is partly sustained by the chemokine eotaxin-3 (CCL26), which extends eosinophil migration into tissues long after allergen exposure. Modulation of CCL26 could represent a means to mitigate airway inflammation. Here we evaluated procyanidin A2 as a means of modulating CCL26 production and investigated interactions with the known inflammation modulator, Interferon γ (IFNγ). We used the human lung epithelial cell line A549 and optimized the conditions for inducing CCL26...
November 12, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27834056/ultradeformable-liposomes-a-novel-vesicular-carrier-for-enhanced-transdermal-delivery-of-procyanidins-effect-of-surfactants-on-the-formation-stability-and-transdermal-delivery
#5
Rencai Chen, Rongli Li, Qian Liu, Chao Bai, Benlin Qin, Yue Ma, Jing Han
The aims of this work were to develop a novel vesicular carrier, procyanidins, ultradeformable liposomes (PUDLs), to expand the applications for procyanidins, and increase their stability and transdermal delivery. In this study, we prepared procyanidins ultradeformable liposomes using thin film hydration method and evaluated their encapsulation efficiency, vesicle deformability, storage stability, and skin permeation in vitro. The influence of different surfactants on the properties of PUDLs was also investigated...
November 10, 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/27827474/the-prothrombotic-state-associated-with-obesity-induced-hypertension-is-reduced-by-cocoa-and-its-main-flavanols
#6
G M Rabadán-Chávez, E Reyes-Maldonado, L Quevedo-Corona, N Paniagua-Castro, G Escalona-Cardoso, M E Jaramillo-Flores
BACKGROUND: Little is known about the effects of cocoa and its main flavanols on the prothrombotic state associated with the development of hypertension in diet-induced obesity models. PURPOSE: To evaluate the effects of cocoa powder, cocoa extract and their main flavanols on plasma biomarkers related to impaired coagulation and fibrinolysis and its association with hypertension and obesity-related metabolic disorders in rats fed a hypercaloric diet. METHODS: Male Wistar rats were randomly assigned to 7 treatment groups (n = 7): normal diet (ND); hypercaloric diet control group (HCD); HCD + cocoa powder (CO); HCD + cocoa extract (CO-EX); HCD + (-)-epicatechin (EPI); HCD + (+)-catechin (CAT); and HCD + procyanidin B2 (PB2)...
November 9, 2016: Food & Function
https://www.readbyqxmd.com/read/27826430/structure-reactivity-relationships-between-the-fluorescent-chromophores-and-antioxidant-activity-of-grain-and-sweet-sorghum-seeds
#7
Minori Uchimiya, Xinzhi Ni, Ming Li Wang
Polyphenolic structures are the putative cause of a variety of seed functions including bird/insect resistance and antioxidant activity. Structure-reactivity relationships are necessary to understand the influence of polyphenolic chromophore structures on the tannin content and free radical quenching ability determined by the traditional calorimetric methods. This study investigated the relationships between the structural attributes of fluorescent chromophore and the following seed characterization methods: procyanidin (by acid-butanol assay) and flavonoid (by vanillin assay) contents, radical quenching (by DPPH assay), electron-donating capacity (by Fe(III) reduction), and λmax (by UV/visible spectrophotometry)...
November 2016: Food Science & Nutrition
https://www.readbyqxmd.com/read/27822524/from-sample-to-multi-omics-conclusions-in-under-48-hours
#8
Robert A Quinn, Jose A Navas-Molina, Embriette R Hyde, Se Jin Song, Yoshiki Vázquez-Baeza, Greg Humphrey, James Gaffney, Jeremiah J Minich, Alexey V Melnik, Jakob Herschend, Jeff DeReus, Austin Durant, Rachel J Dutton, Mahdieh Khosroheidari, Clifford Green, Ricardo da Silva, Pieter C Dorrestein, Rob Knight
Multi-omics methods have greatly advanced our understanding of the biological organism and its microbial associates. However, they are not routinely used in clinical or industrial applications, due to the length of time required to generate and analyze omics data. Here, we applied a novel integrated omics pipeline for the analysis of human and environmental samples in under 48 h. Human subjects that ferment their own foods provided swab samples from skin, feces, oral cavity, fermented foods, and household surfaces to assess the impact of home food fermentation on their microbial and chemical ecology...
March 2016: MSystems
https://www.readbyqxmd.com/read/27816760/high-molecular-weight-cocoa-procyanidins-possess-enhanced-insulin-enhancing-and-insulin-mimetic-activities-in-human-primary-skeletal-muscle-cells-compared-to-smaller-procyanidins
#9
Suzanne M Bowser, William T Moore, Ryan P McMillan, Melanie R Dorenkott, Katheryn M Goodrich, Liyun Ye, Sean F O'Keefe, Matthew W Hulver, Andrew P Neilson
Dysregulation of glucose metabolism is a primary hallmark of metabolic disease (i.e., diabetes, obesity, etc.). Complementary nonpharmaceutical strategies are needed to prevent and/or ameliorate dysregulation of glucose metabolism and prevent progression from normoglycemia to prediabetes and type 2 diabetes across the lifespan. Cocoa compounds, particularly the procyanidins, have shown promise for improving insulin sensitivity and blood glucose homeostasis. However, the molecular mechanisms by which cocoa procyanidins exert these functions remain poorly understood...
January 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/27801843/comparative-transcriptomic-analysis-of-grape-berry-in-response-to-root-restriction-during-developmental-stages
#10
Feng Leng, Qiong Lin, Di Wu, Shiping Wang, Dengliang Wang, Chongde Sun
Root restriction improved berry quality by being involved in diverse aspects of grapevine life. However, the molecular mechanism driving this process is not understood very well. In this study, the 'Summer Black' grape berry (Vitis vinifera × V. labrusca) under root restriction was investigated, which showed an increase of total soluble solids (TSS), color index of red grapes (CIRG) value, anthocyanins accumulation, total phenolics and total procyanidins contents during berry development compared with those in control berries...
October 28, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27796095/structure-activity-relationship-of-condensed-tannins-and-synergism-with-trans-cinnamaldehyde-against-caenorhabditis-elegans
#11
Honorata Małgorzata Ropiak, Olivier Desrues, Andrew Richard Williams, Aina Ramsay, Irene Mueller-Harvey, Stig M Thamsborg
Parasitic gastrointestinal nematodes (GIN) of livestock are increasingly developing resistance to synthetic nematocidal drugs. Moreover, the use of nematocides can induce ecotoxicity by affecting free-living nematodes. Condensed tannins (CT) are a structurally diverse group of bioactive plant compounds possessing anthelmintic activity against GIN. We investigated the relationship between the chemical structure of contrasting, purified CT and nematocidal effects using Caenorhabditis elegans. We also explored whether the nematocidal activity of CT could synergize with trans-cinnamaldehyde (CIN)...
October 31, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27794196/short-term-biomarkers-of-apple-consumption
#12
Theresa Saenger, Florian Hübner, Hans-Ulrich Humpf
SCOPE: Urinary biomarkers are used to estimate the nutritional intake of humans. The aim of this study was to distinguish between low, medium and high apple consumption by quantifying possible intake biomarkers in urine samples after apple consumption by HPLC-MS/MS. Apples were chosen as they are the most consumed fruits in Germany. METHODS AND RESULTS: 30 subjects took part in a seven day study. They abstained from apples and apple products except for one weighed apple portion resembling one, two or four apples...
October 29, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27792335/oral-administration-of-apple-procyanidins-ameliorates-insulin-resistance-via-suppression-of-pro-inflammatory-cytokines-expression-in-liver-of-diabetic-ob-ob-mice
#13
Kasane Ogura, Masahito Ogura, Toshihiko Shoji, Yuichi Sato, Yumiko Tahara, Gen Yamano, Hiroki Sato, Kazu Sugizaki, Naotaka Fujita, Hisato Tatsuoka, Ryota Usui, Eri Mukai, Shimpei Fujimoto, Nobuya Inagaki, Kazuaki Nagashima
Procyanidins, the main ingredient of apple polyphenols, are known to possess anti-oxidative and anti-inflammatory effects associated closely with the pathophysiology of insulin resistance and type 2 diabetes. We investigated the effects of orally administered apple procyanidins (APCs) on glucose metabolism using diabetic ob/ob mice. We found no difference in body weight or body composition between APCs-treated and untreated mice. 4-week oral administration of APCs ameliorated glucose tolerance, insulin resistance, and hepatic gluconeogenesis in ob/ob mice...
October 28, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27788205/a-cinnamon-derived-procyanidin-compound-displays-anti-hiv-1-activity-by-blocking-heparan-sulfate-and-co-receptor-binding-sites-on-gp120-and-reverses-t-cell-exhaustion-via-impeding-tim-3-and-pd-1-upregulation
#14
Bridgette Janine Connell, Sui-Yuan Chang, Ekambaranellore Prakash, Rahima Yousfi, Viswaraman Mohan, Wilfried Posch, Doris Wilflingseder, Christiane Moog, Eiichi N Kodama, Pascal Clayette, Hugues Lortat-Jacob
Amongst the many strategies aiming at inhibiting HIV-1 infection, blocking viral entry has been recently recognized as a very promising approach. Using diverse in vitro models and a broad range of HIV-1 primary patient isolates, we report here that IND02, a type A procyanidin polyphenol extracted from cinnamon, that features trimeric and pentameric forms displays an anti-HIV-1 activity against CXCR4 and CCR5 viruses with 1-7 μM ED50 for the trimer. Competition experiments, using a surface plasmon resonance-based binding assay, revealed that IND02 inhibited envelope binding to CD4 and heparan sulphate (HS) as well as to an antibody (mAb 17b) directed against the gp120 co-receptor binding site with an IC50 in the low μM range...
2016: PloS One
https://www.readbyqxmd.com/read/27777462/effect-of-maceration-duration-on-physicochemical-characteristics-organic-acid-phenolic-compounds-and-antioxidant-activity-of-red-wine-from-vitis-vinifera-l-karaoglan
#15
N Kocabey, M Yilmaztekin, A A Hayaloglu
Effects of different maceration times (5, 10 and 15 days) on composition, phenolic compounds and antioxidant activities of red wines made from the Vitis vinifera L. Karaoglan grown in Malatya were investigated. Maceration duration changed some chemical constituents and color of Karaoglan red wines. A linear relationship was observed between antioxidant activity of wine and maceration duration. Major organic acid was tartaric acid which was at the highest concentration in wine macerated for 10 days. A total of 25 phenolic compounds was determined in wine samples...
September 2016: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/27769428/selectivity-mapping-of-the-binding-sites-of-e-resveratrol-imprinted-polymers-using-structurally-diverse-polyphenolic-compounds-present-in-pinot-noir-grape-skins
#16
Shima N N S Hashim, Lachlan J Schwarz, Basil Danylec, Mahesh K Potdar, Reinhard I Boysen, Milton T W Hearn
This investigation describes a general procedure for the selectivity mapping of molecularly imprinted polymers, using (E)-resveratrol-imprinted polymers as the exemplar, and polyphenolic compounds present in Pinot noir grape skin extracts as the test compounds. The procedure is based on the analysis of samples generated before and after solid-phase extraction of (E)-resveratrol and other polyphenols contained within the Pinot noir grape skins using (E)-resveratrol-imprinted polymers. Capillary reversed-phase high-performance liquid chromatography (RP-HPLC) and electrospray ionisation tandem mass spectrometry (ESI MS/MS) was then employed for compound analysis and identification...
December 1, 2016: Talanta
https://www.readbyqxmd.com/read/27765365/effects-of-low-molecular-weight-procyanidin-rich-extract-from-french-maritime-pine-bark-on-cardiovascular-disease-risk-factors-in-stage-1-hypertensive-subjects-randomized-double-blind-crossover-placebo-controlled-intervention-trial
#17
Rosa-M Valls, Elisabet Llauradó, Sara Fernández-Castillejo, Francesc Puiggrós, Rosa Solà, Lluis Arola, Anna Pedret
BACKGROUND: Oligopin(ۚ) (OP) is a quantified extract from French Maritime Pine bark (FMPB) with low molecular weight procyanidins. The cardioprotective effects of OP need to be tested in human clinical intervention trials with an appropriate design. PURPOSE: The aim of the present study was to assess the effect of subchronic consumption of OP on cardiovascular disease risk factors such as lipid profile, systolic blood pressure (BP) and oxidized-Low Density Lipoprotein (ox-LDL) in stage-1-hypertensive subjects...
November 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/27747228/black-currant-ribes-nigrum-l-and-bilberry-vaccinium-myrtillus-l-fruit-juices-inhibit-adhesion-of-asaia-spp
#18
Hubert Antolak, Agata Czyzowska, Dorota Kregiel
The aim of the study was to evaluate the activity of high-polyphenolic black currant (Ribes nigrum L.) and bilberry (Vaccinium myrtillus L.) juices against bacterial strains Asaia lannensis and Asaia bogorensis isolated as spoilage of commercial soft drinks. The composition of fruit juices was evaluated using chromatographic techniques HPLC and LC-MS. The adhesion to glass, polystyrene, and polyethylene terephthalate in two different culture media was evaluated by luminometry and the plate count method. The major anthocyanins in the V...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27722919/comparative-study-of-the-interactions-between-ovalbumin-and-five-antioxidants-by-spectroscopic-methods
#19
Xiangrong Li, Yunhui Yan
L-Ascorbic acid, α-tocopherol, procyanidin B3, β-carotene and astaxanthin are five classic dietary antioxidants. In this study, the interaction between the five antioxidants and ovalbumin was investigated by fluorescence spectroscopy, in combination with UV-vis absorption spectroscopy and circular dichroism (CD) spectroscopy. The quenching mechanism of ovalbumin by α-tocopherol is static quenching and the interaction between α-tocopherol and ovalbumin is synergistically driven by enthalpy and entropy. Electrostatic interactions and hydrophobic interactions play a major role in stabilizing the complex...
October 8, 2016: Journal of Fluorescence
https://www.readbyqxmd.com/read/27722063/the-protective-effect-of-procyanidin-against-lps-induced-acute-gut-injury-by-the-regulations-of-oxidative-state
#20
Qiu Jue Wu, Yu Qin Wang, Yan Xia Qi
BACKGROUND: A 2 × 4 factorial arrangement of treatments was used to investigate the protective effect of procyanidin (PCA) against lipopolysaccharide (LPS)-induced acute gut injury by the regulations of oxidative state for a 21-days feeding trial. METHODS: A total of 384 1-days-old broiler chicks were assigned to 8 treatments with 8 replicate of 6 broiler chickens per pen. Broiler chickens fed diets based on 4 levels of dietary PCA (0, 0.05, 0.075 and 0.1 % of the requirements)...
2016: SpringerPlus
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