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Procyanidin

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https://www.readbyqxmd.com/read/29331860/c18-core-shell-column-with-in-series-absorbance-and-fluorescence-detection-for-simultaneous-monitoring-of-changes-in-stilbenoid-and-proanthocyanidin-concentrations-during-grape-cane-storage
#1
Vania Sáez, Camila Gayoso, Sebastián Riquelme, Julie Pérez, Carola Vergara, Claudia Mardones, Dietrich von Baer
Grape canes, the residues from the annual pruning of vines, contain high levels of inducible (E)-resveratrol and also oligomeric stilbenoids and proanthocyanidins. These two families of phenolic compounds are bioactive, but to quantify them in a single chromatographic run using only ultraviolet detection is a difficult task. To overcome this limitation, a chromatographic method was developed using a core shell column for separation, an ultraviolet-visible diode array detector (DAD) and a fluorescence (FL) detector connected in series for quantification, with an electrospray ionization interface (ESI) and a triple quadrupole mass spectrometric detector (MS/MS) added for identification of the analytes...
December 29, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29328429/anthocyanins-inhibit-high-glucose-induced-renal-tubular-cell-apoptosis-caused-by-oxidative-stress-in-db-db-mice
#2
Jinying Wei, Haijiang Wu, Haiqiang Zhang, Fang Li, Shurui Chen, Baohua Hou, Yonghong Shi, Lijuan Zhao, Huijun Duan
Oxidative stress is an important contributory factor resulting the development of kidney injury in patients with diabetes. Numerous in vitro and in vivo studies have suggested that anthocyanins, natural phenols commonly existing in numerous fruits and vegetables, exhibit important antioxidative, anti‑inflammatory and antihyperlipidemic effects; however, their effects and underlying mechanisms on diabetic nephropathy (DN) have not yet been fully determined. In the present study, the regulation of apoptosis metabolism and antioxidative effects exhibited by anthocyanins [grape seed procyanidin (GSPE) and cyanidin‑3‑O‑β‑glucoside chloride (C3G)] were investigated, and the molecular mechanism underlying this process was investigated in vivo and in vitro...
January 10, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29315597/american-cranberries-and-health-benefits-an-evolving-story-of-25-years
#3
REVIEW
Shaomin Zhao, Haiyan Liu, Liwei Gu
Cranberries contain various type of bioactive components. Scientists have been studying cranberries' beneficial effects on urinary tract health since the 20th century. Entering the 21st century, the protection of cranberry phytochemicals against cancer and vascular diseases has drawn more attention from researchers. Anthocyanins, procyanidins, and flavonols in cranberries were all documented to have potential effects on cancer prevention. The cardiometabolic effects of cranberries have been investigated in several clinical trials...
January 9, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29315228/contribution-of-secondary-metabolites-to-the-gastroprotective-effect-of-aqueous-extract-of-ximenia-americana-l-olacaceae-stem-bark-in-rats
#4
Ticiana Parente Aragão, Lady Dayane Kalline Travassos Dos Prazeres, Samara Alves Brito, Pedro José Rolim Neto, Larissa Araújo Rolim, Jackson Roberto Guedes da Silva Almeida, Germana Freire Rocha Caldas, Almir Gonçalves Wanderley
Ximenia americana L. (Olacaceae) is used in ethnomedicine as cicatrizant and for the treatment of gastric disorders. This study identified the chemical constituents of the aqueous extract of X. americana (XaAE) and evaluated its antiulcerogenic activity. After lyophilization, XaAE was analyzed by liquid chromatography-mass spectrometry (LC-MS) and its antiulcerogenic effect was evaluated in acute gastric lesions induced by ethanol, acidified ethanol, and indomethacin. Antisecretory action, mucus production and the participation of sulfhydryl groups (-SH) and nitric oxide (NO) were also investigated...
January 9, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29313327/condensed-tannins-from-longan-bark-as-inhibitor-of-tyrosinase-structure-activity-and-mechanism
#5
Qian Huang, Mei-Zhen Lin, Wei Ming Chai, Chong Ou-Yang, Wen-Yang Huang, Ying-Xia Wang, Kai-Li Xu, Hui-Ling Feng
In this study, the content, structure, anti-tyrosinase activity and mechanism of longan bark condensed tannins were evaluated. The findings obtained from mass spectrometry demonstrated that longan bark condensed tannins were mixtures of procyanidins, propelargonidins, prodelphinidins, and their acyl derivatives (galloyl and p-hydroxybenzoate). The enzyme analysis indicated that these mixtures were efficient, reversible, and mixed (competitive is dominant) inhibitor of tyrosinase. What's more, the mixtures showed good inhibitions on proliferation, intracellular enzyme activity and melanogenesis of mouse melanoma cells (B16 )...
January 9, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29287430/comprehensive-identification-of-bioactive-compounds-of-avocado-peel-by-liquid-chromatography-coupled-to-ultra-high-definition-accurate-mass-q-tof
#6
Jorge G Figueroa, Isabel Borrás-Linares, Jesús Lozano-Sánchez, Antonio Segura-Carretero
Industrially the avocado pulp is exploited principally as oil and paste, generating a huge quantity of peel and seed as by-products. Avocado peel is a promising inexpensive candidate for recovery phenolic compounds. The aim of this work was to identify the bioactive compounds present in an extract of avocado peel obtained by a green extraction technique. Accelerated solvent extraction was performed using water and ethanol as extraction solvents. Liquid chromatography coupled to ultra-high-definition accurate-mass spectrometry was used in order to identify the bioactive compounds...
April 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29279088/procyanidin-a2-in-the-australian-plant-alectryon-oleifolius-has-anthelmintic-activity-against-equine-cyathostomins-in-vitro
#7
S E Payne, G R Flematti, A Reeder, A C Kotze, Z Durmic, P E Vercoe
There is a need to investigate new methods of controlling cyathostomins in horses due to increasing anthelmintic resistance amongst these parasites. In a previous study we identified the Australian plant Alectryon oleifolius as having anthelmintic activity towards cyathostomins. This study aimed to isolate and identify the bioactive compound(s) responsible for all or part of this anthelmintic activity and quantify its activity in vitro. The condensed tannin procyanidin A2 was isolated from the plant through a process of bioassay guided fractionation and identified using 1D and 2D nuclear magnetic resonance spectroscopy and high performance liquid chromatography with mass spectrometry...
January 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29243419/-advances-of-mechanism-research-on-procyanidin-in-prevention-and-treatment-of-type-2-diabetes-mellitus
#8
REVIEW
Xue-Ping Wang, Yi-Ming Li, Zhao Wang, Qi Jia, Kai-Xian Chen
Diabetes mellitus, a chronic disease, is characterized by high blood glucose that could induce various complications. Procyanidin, a kind of polyphenol compounds existing in many plants, have shown to be effective in preventing and treating type 2 diabetes mellitus as they may lower blood glucose, moderate insulin resistance and protect islet β cells. This review focused on the research advances on the preventive and therapeutic application of procyanidin in promoting glucose absorption, protecting islet β cells, modulating intestinal microbiota and regulating diabetic complications of type 2 diabetes mellitus, which should provide useful reference for subsequent studies...
October 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29209349/regulation-of-fig-ficus-carica-l-fruit-color-metabolomic-and-transcriptomic-analyses-of-the-flavonoid-biosynthetic-pathway
#9
Ziran Wang, Yuanyuan Cui, Alexander Vainstein, Shangwu Chen, Huiqin Ma
Combined metabolomic and transcriptomic analyses were carried out with fig cultivar Green Peel and its color mutant "Purple Peel." Five and twenty-two metabolites were identified as having significantly different contents between fruit peels of the two cultivars at young and mature stages, respectively. Cyanidin O-malonylhexoside demonstrated a 3,992-fold increase in the mature purple peel, the first identification of a major cyanidin in fig fruit; cyanidin 3-O-glucoside, cyanidin O-malonylhexoside O-hexoside and cyanidin-3,5-O-diglucoside were upregulated 100-fold, revealing the anthocyanins underlying the purple mutation...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29196003/chemical-profiling-of-guarana-seeds-paullinia-cupana-from-different-geographical-origins-using-uplc-qtof-ms-combined-with-chemometrics
#10
Givaldo Souza da Silva, Kirley Marques Canuto, Paulo Riceli Vasconcelos Ribeiro, Edy Sousa de Brito, Madson Moreira Nascimento, Guilherme Julião Zocolo, Janclei Pereira Coutinho, Raildo Mota de Jesus
Paullinia cupana, commonly known as guarana, is an Amazonian fruit whose seeds are used to produce the powdered guarana, which is rich in caffeine and consumed for its stimulating activity. The metabolic profile of guarana from the two largest producing regions was investigated using UPLC-MS combined with multivariate statistical analysis. The principal component analysis (PCA) showed significant differences between samples produced in the states of Bahia and Amazonas. The metabolites responsible for the differentiation were identified by orthogonal partial least squares discriminant analysis (OPLS-DA)...
December 2017: Food Research International
https://www.readbyqxmd.com/read/29195957/effect-of-a-commercial-tannin-on-the-sensorial-temporality-of-astringency
#11
M Medel-Marabolí, J L Romero, E Obreque-Slier, A Contreras, A Peña-Neira
Astringency is a tactile sensation that is generated by a reduction in lubrication in the oral cavity and is generally attributed to the interaction of procyanidins or condensed tannins with salivary proteins. Several factors influence tannin-protein interactions, such as pH, alcohol, sweetness, oxygen and polyphenol content. A scarcely studied factor is the effect of the tannin content on the perception of astringency. The objective of this study was to evaluate the effect of different concentrations of commercial oenological tannin (COT) on the timing of the perception of astringency...
December 2017: Food Research International
https://www.readbyqxmd.com/read/29189132/polyphenols-novel-signaling-pathways
#12
Marie-Louise Ricketts, Bradley S Ferguson
BACKGROUND: Cardiovascular disease (CVD) is currently the leading cause of death globally. The metabolic syndrome (MetS), a clustering of risk factors including hypertension, hyperglycemia, elevated low-density lipoprotein (LDL) cholesterol, reduced high-density lipoprotein (HDL) cholesterol and increased visceral adiposity, is a significant risk factor for the development of CVD. Non-alcoholic fatty liver disease (NAFLD), often referred to as the hepatic manifestation of MetS, is a constellation of progressive liver disorders closely linked to obesity, diabetes, and insulin resistance...
November 29, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29188040/evaluation-of-peanut-skin-and-grape-seed-extracts-to-inhibit-growth-of-foodborne-pathogens
#13
Jason Levy, Renee R Boyer, Andrew P Neilson, Sean F O'Keefe, Hyun Sik S Chu, Robert C Williams, Melanie R Dorenkott, Katheryn M Goodrich
Peanut skin extract (PSE) and grape seed extract (GSE) are derived from waste products in the wine and peanut industries, respectively. Both have high concentrations of polyphenols, known to possess antioxidant and antimicrobial properties. PSE primarily contains "A-type" procyanidins, while GSE primarily contains "B-type" procyanidins. These differ structurally, but are both isomers of epicatechin dimers. The objective of this study was to evaluate the antimicrobial effects of PSE containing A-type procyanidins and GSE containing B-type procyanidins against select foodborne pathogens (Listeria monocytogenes, Escherichia coli O157:H7, and Salmonella Typhimurium)...
November 2017: Food Science & Nutrition
https://www.readbyqxmd.com/read/29175668/grape-seed-procyanidin-extract-ameliorates-lead-induced-liver-injury-via-mirna153-and-akt-gsk-3%C3%AE-fyn-mediated-nrf2-activation
#14
Biying Liu, Huijie Jiang, Jingjing Lu, Ruiqi Baiyun, Siyu Li, Yueying Lv, Da Li, Hao Wu, Zhigang Zhang
Lead-induced hepatotoxicity is characterized by an extensive oxidative stress. Grape seed procyanidin extract (GSPE) possesses abundant biological activities. Herein, we investigated the protective role of GSPE against lead-induced liver injury and determined the potential molecular mechanisms. In vivo, rats were treated with/without lead acetate (PbAc) (0.05%, w/v) in the presence/absence of GSPE (200 mg/kg). In vitro, hepatocytes were pretreated with/without GSPE (100 μg/ml) in the presence/absence of PbAc (100 μM)...
October 12, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29156717/oligomer-procyanidins-f2-repress-hif-1%C3%AE-expression-in-human-u87-glioma-cells-by-inhibiting-the-egfr-akt-mtor-and-mapk-erk1-2-signaling-pathways-in-vitro-and-in-vivo
#15
Hong-Li Zheng, Li-Hui Wang, Bao-Shan Sun, Yi Li, Jing-Yu Yang, Chun-Fu Wu
Hypoxia-inducible factor-1 (HIF-1) is over-expressed in gliomas and has become one of the most compelling tumor targets. In this study, we found that oligomer procyanidins (F2) can suppress the expressions of HIF-1α and its target genes in U87 cells, and also down-regulate the EGFR/PI3K/AKT/mTOR and MAPK/ERK1/2 pathways in vitro and in vivo. Furthermore, hypoxia-induced formation of tubular structures by human umbilical vascular endothelial cells and the migration and invasion of U87 cells could be inhibited by F2 in a HIF-1 dependent manner...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156573/neuraminidase-inhibitory-activity-and-constituent-characterization-of-fagopyrum-dibotrys
#16
Xiang Zhang, Yu Cao, Jinhua Li, Ailin Liu, Haibo Liu, Linfang Huang
This study aimed to identify a new biological activity of the widely distributed species Fagopyrum dibotrys. Four F. dibotrys extracts (ethyl acetate (EA), petroleum ether (P), ethanol (E), and water (W)) were explored for their anti-neuraminidase (NA) activity. A total of 32 compounds were identified using UHPLC-Q-Exactive Orbitrap HRMS in the EA extract, which had the best NA inhibitory effects. We used the docking data for supporting compounds' anti-neuraminidase activity. Among them, five compounds including one flavonoid, three organic acids, and one glucoside were discovered for the first time in F...
November 18, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29151068/crataegus-special-extract-ws-1442-up-to-date-review-of-experimental-and-clinical-experiences
#17
M Zorniak, B Szydlo, T F Krzeminski
Extracts and tinctures made from Crataegus spp. (Hawthorn) have been used as cardioprotective remedies since ancient times. WS 1442 special extract, manufactured by Dr. W. Schwabe Pharmaceuticals©, made from Crataegus spp. Leaves and flowers is one of the most studied and popular of preparations received from Hawthorn. It is integral, and most important active component of such herbal drugs as Crataegutt® novo 450, and CardioMax®. This standardized extract contains 18.75% oligomeric procyanidins (OPC), which have beneficial cardioprotective values and play a role as free-radicals scavengers, that protect the ischemic heart tissue from neutrophile elastase action successions...
August 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/29146371/comparison-of-the-protective-effect-of-black-and-white-mulberry-against-ethyl-carbamate-induced-cytotoxicity-and-oxidative-damage
#18
Yuting Li, Tao Bao, Wei Chen
Increasing evidence indicates that crude extracts derived from mulberry confer protection against oxidative stress. However, the antioxidant capacity of mulberry extract among different cultivars remains elusive. The main objective of the present study was therefore to investigate the effect of black mulberry extract (BMB) and white mulberry extract (WMB) on ethyl carbamate (EC)-induced cytotoxicity and oxidative stress. This study showed that the contents of total phenolics, total flavonoids, total procyanidins, cyanidin-3-O-glucoside, cyanidin-3-O-rutinoside and pelargonidin-3-O-glucoside of BMB were higher than that of WMB...
March 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29146325/study-of-human-salivary-proline-rich-proteins-interaction-with-food-tannins
#19
Susana Soares, Ignacio García-Estévez, Raúl Ferrer-Galego, Natércia F Brás, Elsa Brandão, Mafalda Silva, Natércia Teixeira, Fátima Fonseca, Sérgio F Sousa, Frederico Ferreira-da-Silva, Nuno Mateus, Victor de Freitas
In this work, saturation transfer difference-NMR, isothermal microcalorimetry and molecular dynamics simulations have been used to study the individual interactions between basic, glycosylated and acidic proline-rich proteins (bPRPS, gPRPs, aPRPs) and P-B peptide with some representative food tannins [procyanidin B2, procyanidin B2 3'-O-gallate (B2g) and procyanidin trimer (catechin-4-8-catechin-4-8-catechin)]. Results showed that P-B peptide was in general the salivary protein (SP) with higher affinity whereas aPRPs showed lower affinity to the studied procyanidins...
March 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29140273/larix-decidua-bark-as-a-source-of-phytoconstituents-an-lc-ms-study
#20
Valeria Baldan, Stefania Sut, Marta Faggian, Elena Dalla Gassa, Sara Ferrari, Gabriele De Nadai, Stefano Francescato, Gianni Baratto, Stefano Dall'Acqua
Larix decidua bark is a waste of the timber industry and is widely diffused in Northern Italy. This material can be considered a good source of antioxidants and phytoconstituents with possible use in cosmetic or nutraceutical products. In this study, simple extraction of larch bark was performed using mixtures of ethanol/water. Furthermore, the phytochemical composition of larch bark extract was studied using LC-MS(n) methods and the main constituents were identified as flavonoids, spiro-polyphenols, and procyanidins...
November 15, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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