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Procyanidin

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https://www.readbyqxmd.com/read/28528103/addition-of-exogenous-enzymes-to-diets-containing-grape-pomace-effects-on-intestinal-utilization-of-catechins-and-antioxidant-status-of-chickens
#1
S Chamorro, A Viveros, A Rebolé, I Arija, C Romero, I Alvarez, A Rey, A Brenes
Grape pomace (GP) is a rich source of polyphenols with antioxidant capacity. An experiment was conducted to study the effect of GP phenolic compounds included at 5 and 10%, and the addition (individually or combined) of hydrolyzing enzymes (carbohydrase enzyme complex and tannase at 500ppm) on intestinal utilization of catechins and antioxidant status in broiler chickens. A diet supplemented with 200ppm of α-tocopheryl acetate was also used. Our findings demonstrate the capacity of chickens to digest the monomeric (catechin, epicatechin, gallic acid, and epicatechin-O-gallate) and dimeric (procyanidin B1 and procyanidin B2) catechins present in grape pomace...
June 2017: Food Research International
https://www.readbyqxmd.com/read/28522973/profiling-and-distribution-of-metabolites-of-procyanidin-b2-in-mice-by-uplc-dad-esi-it-tof-ms-n-technique
#2
Ying Xiao, Zhongzhi Hu, Zhiting Yin, Yiming Zhou, Taiyi Liu, Xiaoli Zhou, Dawei Chang
The metabolite profiles and distributions of procyanidin B2 were qualitatively described using UPLC-DAD-ESI-IT-TOF-MS(n) without help of reference standards, and a possible metabolic pathway was proposed in the present study. Summarily, 53 metabolites (24 new metabolites) were detected as metabolites of procyanidin B2, and 45 of them were tentatively identified. Twenty seven metabolites were assigned as similar metabolites of (-)-epicatechin by scission of the flavanol interflavanic bond C4-C8, including 16 aromatic metabolites, 5 conjugated metabolites, 3 ring-cleavage metabolites, and 2 phenylvalerolactone metabolites...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28514152/hepatoprotective-properties-of-a-polyphenols-enriched-fraction-from-annona-crassiflora-mart-fruit-peel-against-diabetes-induced-oxidative-and-nitrosative-stress
#3
Allisson B Justino, Mariana N Pereira, Leonardo G Peixoto, Danielle D Vilela, Douglas C Caixeta, Adriele V de Souza, Renata R Teixeira, Heitor C G Silva, Francyelle B R de Moura, Izabela B Moraes, Foued Salmen Espindola
A polyphenols-enriched fraction from Annona crassiflora fruit peel (Ac-Pef) containing chlorogenic acid, (epi)catechin, procyanidin B2 and caffeoyl-glucoside was investigated against hepatic oxidative and nitrosative stress in streptozotocin-induced diabetic rats. Serum biochemical parameters, hepatic oxidative and nitrosative status, glutathione defense system analysis, and in silico assessment of absorption, distribution, metabolism, excretion and toxicity (ADMET) of the main compounds of Ac-Pef were carried out...
May 17, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28505543/chronic-administration-of-apple-polyphenols-ameliorates-hyperglycaemia-in-high-normal-and-borderline-subjects-a-randomised-placebo-controlled-trial
#4
Toshihiko Shoji, Mitsuhiro Yamada, Tomisato Miura, Kazuaki Nagashima, Kasane Ogura, Nobuya Inagaki, Mari Maeda-Yamamoto
AIMS: We previously reported that apple polyphenols (AP) and their major active components, procyanidins, had beneficial effects on glucose homeostasis and diabetes in diabetic ob/ob mice. The present study was performed to evaluate the effects of chronic AP administration on glucose tolerance in high-normal and borderline human subjects. METHODS: Subjects (n=65) with a fasting plasma glucose (FPG) level of 100-125mg/dL determined during a recent health check-up were randomised to receive tablets containing AP (600mg/day) or placebo tablets for 12weeks in a double-blinded, placebo-controlled clinical trial...
May 2, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28497962/the-potential-of-polygonum-cuspidatum-root-as-an-antidiabetic-food-dual-high-resolution-%C3%AE-glucosidase-and-ptp1b-inhibition-profiling-combined-with-hplc-hrms-and-nmr-for-identification-of-antidiabetic-constituents
#5
Yong Zhao, Martin Xiaoyong Chen, Kenneth Thermann Kongstad, Anna K Jager, Dan Staerk
The Worldwide increasing incidence of type 2 diabetes has fuelled an intensified search for food and herbal remedies with preventive and/or therapeutic properties. Polygonum cuspidatum Siebold & Zucc. (Polygonaceae) is used as a functional food in Japan and South Korea, and it's also a well-known traditional antidiabetic herb used in China. In this study, dual high-resolution α-glucosidase and protein-tyrosine phosphatase 1B (PTP1B) inhibition profiling was used for identification of individual antidiabetic constituents directly from the crude ethyl acetate extract and fractions of P...
May 12, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28490110/multivariate-statistical-analysis-of-the-polyphenolic-constituents-in-kiwifruit-juices-to-trace-fruit-varieties-and-geographical-origins
#6
Jing Guo, Yahong Yuan, Pei Dou, Tianli Yue
Fifty-one kiwifruit juice samples of seven kiwifruit varieties from five regions in China were analyzed to determine their polyphenols contents and to trace fruit varieties and geographical origins by multivariate statistical analysis. Twenty-one polyphenols belonging to four compound classes were determined by ultra-high-performance liquid chromatography coupled with ultra-high-resolution TOF mass spectrometry. (-)-Epicatechin, (+)-catechin, procyanidin B1 and caffeic acid derivatives were the predominant phenolic compounds in the juices...
October 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28487962/embryotoxicity-estimation-of-commonly-used-compounds-with-embryonic-stem-cell-test
#7
Hui Liu, Caiping Ren, Weidong Liu, Xingjun Jiang, Lei Wang, Bin Zhu, Wei Jia, Jianxing Lin, Jun Tan, Xiuying Liu
The embryonic stem cell test (EST), an alternative model to animal studies, is a reliable and scientifically validated in vitro system for testing embryotoxicity. In contrast to most in vivo animal tests, two permanent cell lines, murine fibroblasts (BALB/c‑3T3 cells) and murine embryonic stem cells (mES‑D3 cells), are used in EST instead of animals in standard tests of toxicity. The embryotoxic potential of compounds (non, weak or strong embryotoxicity) may be obtained with a biostatistics‑based prediction model and calculated from three different experimental endpoint values: The potency to inhibit growth of i) BALB/c‑3T3 cells and ii) mES‑D3 cells (IC503T3 and IC50ES) as presented using a cell cytotoxicity assay, and iii) the potency to inhibit differentiation of mES‑D3 cells into contracting cardiomyocytes (ID50 D3) as demonstrated in a mES‑D3 cell differentiation assay...
May 9, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28472615/interaction-of-procyanidin-b3-with-membrane-lipids-fluorescence-dsc-and-ftir-studies
#8
Sylwia Cyboran-Mikołajczyk, Romuald Żyłka, Piotr Jurkiewicz, Hanna Pruchnik, Jan Oszmiański, Martin Hof, Halina Kleszczyńska
Procyanidins, contained in many products abundant in human diet, exhibit high biological activity. However, this activity has not been fully explained at cellular and molecular levels. In this study, we determine the mechanism of interaction of procyanidin B3 with model lipid membrane. This mechanism was established on the basis of changes induced by B3 in the physical properties of lipid bilayer. The changes were investigated using steady state and time-resolved fluorescence, DSC, and FTIR. We show that procyanidin B3 causes changes in the arrangement of the polar heads of lipids, order of their acyl chains and the main lipid phase transition temperature...
May 1, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28471298/optimized-ultra-high-pressure-assisted-extraction-of-procyanidins-from-lychee-pericarp-improves-the-antioxidant-activity-of-extracts
#9
Ruifen Zhang, Dongxiao Su, Fangli Hou, Lei Liu, Fei Huang, Lihong Dong, Yuanyuan Deng, Yan Zhang, Zhencheng Wei, Mingwei Zhang
To establish optimal ultra-high-pressure (UHP)-assisted extraction conditions for procyanidins from lychee pericarp, a response surface analysis method with four factors and three levels was adopted. The optimum conditions were as follows: 295 MPa pressure, 13 min pressure holding time, 16.0 mL/g liquid-to-solid ratio, and 70% ethanol concentration. Compared with conventional ethanol extraction and ultrasonic-assisted extraction methods, the yields of the total procyanidins, flavonoids, and phenolics extracted using the UHP process were significantly increased; consequently, the oxygen radical absorbance capacity and cellular antioxidant activity of UHP-assisted lychee pericarp extracts were substantially enhanced...
May 4, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28460948/enzymatic-biotransformation-of-polyphenolics-increases-antioxidant-activity-of-red-and-white-grape-pomace
#10
Isabela M Martins, Bruna S Roberto, Jeffrey B Blumberg, C-Y Oliver Chen, Gabriela A Macedo
Grape pomace (GP) is a polyphenolic-rich byproduct of wine production. As most polyphenolics are either bound to cellular matrices or present as free polymeric forms, treatment with hydrolytic enzymes may act to increase GP functionalities. The aim of this study was to examine the impact of tannase alone (T), pectinase plus cellulase (PC) or a mixture of them (TPC) on the hydrolysis of polyphenolics in red GP (RGP), white GP (WGP), and mixed GP (MGP) from Brazilian wine production, as well as antioxidant activity of the products...
November 2016: Food Research International
https://www.readbyqxmd.com/read/28449181/metabolite-profile-and-antiproliferative-effects-in-hacat-cells-of-a-salix-reticulata-extract
#11
Elisabetta Corradi, Nadine Schmidt, Nathalie Räber, Maria De Mieri, Matthias Hamburger, Veronika Butterweck, Olivier Potterat
Phenolic constituents of Salix reticulata (Salicaceae) and antiproliferative activity of an extract and individual compounds were investigated in immortalized human non-tumorigenic keratinocytes (HaCaT). A MeOH extract from aerial parts afforded several flavonoids, including luteolin and apigenin glycosides (2-5 and 9) and catechin (1), two procyanidin fractions, and the phenolic glucosides picein (6), triandrin (7), and salicortin (8). In an adenosine triphosphate assay, the MeOH extract reduced cell viability by approximately 60 % at a concentration of 100 µg/mL...
April 27, 2017: Planta Medica
https://www.readbyqxmd.com/read/28445856/procyanidin-a-kind-of-biological-flavonoid-induces-protective-anti-tumor-immunity-and-protects-mice-from-lethal-b16f10-challenge
#12
Lina Zhang, Shuang Wang, Zeyuan Liu, Li Zhang, Shanzheng Wang, Bin Wang
Recently, increasing evidences show that procyanidin (PC) modulate immune responses in human. To evaluate adjuvant effects of PC on vaccine immune modulation and anti-tumor activity, we formulated PC with B16F10 tumor antigen as tumor vaccine to immune C57BL/6 mice and used intramuscular injection before challenge with tumor B16F10 cells. Our results revealed that PC enhanced T cell-mediated immune responses both in vitro and in vivo. Moreover, the B16F10 tumor vaccine induced some degree of anti-tumor effects as evaluated by the inhibition of tumor growth and the prolongation of survival...
April 23, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28416338/separation-and-purification-of-polyphenols-from-red-wine-extracts-using-high-speed-counter-current-chromatography
#13
Yuanyuan Li, Lingxi Li, Yan Cui, Shuting Zhang, Baoshan Sun
Polyphenols are important compounds of red wine owing to their contribution to sensory properties and antioxidant activities. In this study, high-speed counter-current chromatography (HSCCC) coupled with semi-preparative HPLC was used for large-scale separation and purification of polyphenols from red wine extracts. With the solvent system of hexane-ethyl acetate-water (1-50-50), various oligomeric procyanidins including monomer catechin, epicatechin, dimers B1, B2; phenolic acids including coutaric acid, caftaric acid and other type of polyphenols were largely separated within 370min and most of these compounds presented high yields (0...
March 12, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28414437/phenolic-content-and-antioxidant-activity-during-the-development-of-brookfield-and-mishima-apples
#14
Mayara C Stanger, Cristiano A Steffens, Cristina Soethe, Marcelo A Moreira, Cassandro V T do Amarante
The aim of this study was to characterize the changes in the contents of total (TPC) and individual (IPC) phenolic compounds, the total antioxidant activity (TAA) in the peel and pulp, and total anthocyanins (TAN) in the peel during the development of the fruits of 'Brookfield' and 'Mishima' apple trees. 'Brookfield' apples were harvested from the 49th to the 138th days after full bloom (DAFB) and 'Mishima' apples from the 45th to the 172th DAFB. In the pulp, the IPC, TPC, and TAA rapidly reduced at 75 and 79 DAFB for the 'Brookfield' and 'Mishima' apples, respectively, and then remained constant until commercial maturity...
April 24, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28414054/endothelium-dependent-vasorelaxant-effect-of-procyanidin-b2-on-human-internal-mammary-artery
#15
Aleksandra Novakovic, Marija Marinko, Goran Jankovic, Ivan Stojanovic, Predrag Milojevic, Dragoslav Nenezic, Vladimir Kanjuh, Qin Yang, Guo-Wei He
The aim of the present study was to investigate and characterize vasorelaxant effect of procyanidin B2 on human internal mammary artery (HIMA) as one of the mechanisms of its protective effect against vascular risk. Procyanidin B2 induced strong concentration-dependent relaxation of HIMA rings pre-contracted by phenylephrine. Pretreatment with L-NAME, a NO synthase inhibitor, hydroxocobalamin, a NO scavenger, and ODQ, an inhibitor of soluble guanylate cyclase, significantly inhibited procyanidin B2-induced relaxation of HIMA, while indomethacin, a cyclooxygenase inhibitor, considerably reduced effects of low concentrations...
April 13, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28409159/nutritional-composition-and-phytochemical-antioxidative-and-antifungal-activities-of-pergularia-tomentosa-l
#16
Imen Lahmar, Hafedh Belghith, Ferjani Ben Abdallah, Karima Belghith
Crude extracts from a medicinal Tunisian plant, Pergularia tomentosa L., were the investigated natural material. Butanolic extract of roots analyzed with IR spectra revealed the presence of hydroxyl, alcoholic, and carboxylic groups and sugars units. Analysis of some secondary metabolites, total phenolic, flavonoids, flavonols, and procyanidins, was performed using different solvents following the increased gradient of polarity. Fruits and leaves contained the highest amounts of all these compounds. Antioxidant properties were evaluated by the determination of free radical scavenging activity and the reducing power of methanolic extracts...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28395820/characterization-and-quantification-of-fruit-phenolic-compounds-of-european-and-tunisian-pear-cultivars
#17
Marwa Brahem, Catherine M G C Renard, Severin Eder, Michèle Loonis, Rim Ouni, Messaoud Mars, Carine Le Bourvellec
The flesh and peel of 19 pear cultivars (8 Tunisian dessert cultivars, 8 European dessert cultivars and 3 French perry pear cultivars) were studied for their phenolic composition. Phenolic compounds were identified by HPLC/ESI-MS(2) and individually quantified by HPLC-DAD. Five classes of polyphenols were present: flavan-3-ols, phenolic acids, flavonols, anthocyanins and simple phenolics (hydroquinones). The total phenolic content ranged between 0.1g/kg Fresh Weight (FW) ('Conference' cultivar) and 8.6g/kg FW ('Plant De Blanc' cultivar) in the flesh and between 1...
May 2017: Food Research International
https://www.readbyqxmd.com/read/28385033/a-new-procyanidin-b-from-campylospermum-zenkeri-ochnaceae-and-antiplasmodial-activity-of-two-derivatives-of-%C3%A2-serotobenine
#18
Norbert Mbabi Nyemeck, Dominique Serge Ngono Bikobo, Auguste Abouem A Zintchem, Eva-Maria Schäfer, Christian Bochet, Dieudonné Emmanuel Pegnyemb, Ulrich Koert
Phytochemical investigation of the stem bark of Campylospermum zenkeri led to the isolation of five known compounds: (Z,Z)-9,12-octadecadienoic acid (1), serotobenine (2), agathisflavone (3), lophirone A (4) and lophirone F (5), together with a new derivative of procyanidin B, a catechin dimer named zenkerinol (6). Serotobenine (2) is structurally related to decursivine which shows moderate activity against D6 and W2 strains of Plasmodium falciparum. For a better understanding of structure-activity relationships, three new semi-synthetic derivatives of serotobenine (2) have been prepared...
April 7, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28383067/the-proposed-biosynthesis-of-procyanidins-by-the-comparative-chemical-analysis-of-five-camellia-species-using-lc-ms
#19
Liang Zhang, Yuling Tai, Yijun Wang, Qilu Meng, Yunqiu Yang, Shihua Zhang, Hua Yang, Zhengzhu Zhang, Daxiang Li, Xiaochun Wan
The genus Camellia (C.) contains many species, including C. sinensis, C. assamica, and C. taliensis, C. gymnogyna and C. tachangensis. The polyphenols of C. sinensis and C. assamica are flavan-3-ols monomers and their dimers and trimmers. However, the biosynthesis of procyanidins in Camellia genus remains unclear. In the present study, a comparative chemical analysis of flavan-3-ols, flavan-3-ols glycoside and procyanidins was conducted by high performance liquid chromatography (HPLC) and liquid chromatography diode array detection coupled with triple-quadrupole mass-spectrometry (LC-DAD-QQQ-MS)...
April 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28376889/grape-seed-derived-procyanidins-alleviate-gout-pain-via-nlrp3-inflammasome-suppression
#20
Hai-Jiao Liu, Xiu-Xiu Pan, Bing-Qian Liu, Xuan Gui, Liang Hu, Chun-Yi Jiang, Yuan Han, Yi-Xin Fan, Yu-Lin Tang, Wen-Tao Liu
BACKGROUND: Gout is one of the common inflammatory arthritis which affects many people for inflicting unbearable pain. Macrophage-mediated inflammation plays an important role in gout. The uptake of monosodium urate (MSU) crystals by macrophages can lead to activation of NOD-like receptors containing a PYD 3 (NLRP3) inflammasome, thus accelerating interleukin (IL)-1β production. Reactive oxygen species (ROS) promoted development of the inflammatory process through NLRP3 inflammasome...
April 4, 2017: Journal of Neuroinflammation
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