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Proanthocyanidin

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https://www.readbyqxmd.com/read/28740952/preventing-oxygen-free-radical-damage-by-proanthocyanidin-in-obstructive-jaundice
#1
Mervan Savdan, Murat Çakır, Hüsamettin Vatansev, Tevfik Küçükkartallar, Ahmet Tekin, Şakir Tavlı
OBJECTIVE: Tissue damage and endotoxemia in obstructive jaundice are attributed to the increase in oxygen free-radicals. We aimed at evaluating the possible protective effect of grape seed proanthocyanidin extract (GSPE), which is a potent exogenous free-radical scavenger and antioxidant. MATERIAL AND METHODS: The study was performed at the Necmettin Erbakan University Meram School of Medicine Research and Application Center for Experimental Medicine Laboratory with ethical approval...
2017: Turk J Surg
https://www.readbyqxmd.com/read/28716425/characterization-and-quantification-of-flavonoids-and-organic-acids-over-fruit-development-in-american-cranberry-vaccinium-macrocarpon-cultivars-using-hplc-and-apci-ms-ms
#2
Yifei Wang, Jennifer Johnson-Cicalese, Ajay P Singh, Nicholi Vorsa
Cranberry flavonoids, including anthocyanins, flavonol glycosides and proanthocyanidins, and organic acids were characterized and quantified by HPLC and LC-MS/MS during fruit development and ripening in eight cranberry cultivars. Anthocyanin biosynthesis initiated at early fruit development and reached highest level in mature fruit, with significant differences between cultivars. Major flavonol glycosides, including the most abundant quercetin-3-galactoside and myricetin-3-galactoside, showed consistent concentrations during the season with moderate fluctuation, and were at similar levels in mature fruits of the eight cultivars...
September 2017: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/28694471/evaluate-the-effect-of-different-mmps-inhibitors-on-adhesive-physical-properties-of-dental-adhesives-bond-strength-and-mmp-substarte-activity
#3
Pei Zheng, Hui Chen
We have evaluated and compare the effect of different exogenous MMP inhibitors on adhesive physical properties of dental adhesives, bond strength, micro permeability and MMP substrate activity. 180-grit Sic paper was used to obtain the superficial dentin surface from each and every tooth after the wet grinding procedure. Dentin was exposed to four different MMP inhibitors to evaluate the effect on resin adhesive dentin interface. The four groups used in study were: 2% chlorhexidine digluconate, 2% doxycycline solution, 5% Proanthocyanidin (PR), Control Group...
July 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28693994/ferritin-glycosylated-by-chitosan-as-a-novel-egcg-nano-carrier-structure-stability-and-absorption-analysis
#4
Rui Yang, Yuqian Liu, Yunjing Gao, Yongjin Wang, Chris Blanchard, Zhongkai Zhou
Ferritin is a shell-like carrier protein with an 8nm diameter cavity which endows a natural space to encapsulate food and drug components. In this work, phytoferritin was unprecedentedly glycosylated by chitosan to fabricate ferritin-chitosan Maillard reaction products (FCMPs) (grafting degree of 26.17%, 24h, 55°C). Results indicated that the amide I and II bands of ferritin were altered due to the chitosan grafting, whereas the ferritin spherical structure were retained. Simulated digestion analysis showed that the FCMPs were more resistant to pepsin and trypsin digestion as compared with ferritin alone...
July 7, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28692939/oligomeric-proanthocyanidin-derived-from-grape-seeds-inhibited-nf-%C3%AE%C2%BAb-signaling-in-activated-hsc-involvement-of-jnk-erk-mapk-and-pi3k-akt-pathways
#5
Min Jiang, Yan-Ling Wu, Xia Li, Yu Zhang, Kai-Li Xia, Ben-Wen Cui, Li-Hua Lian, Ji-Xing Nan
In current study, we aimed to reveal the potential antifibrotic effects of oligomeric proanthocyanidin (OPC) from grape seeds on lipopolysaccharide (LPS)-activated, HSC-T6, a rat hepatic stellate cell line. HSC-T6 cells were treated with OPC 1h prior to LPS, and then incubated for indicated time. OPC inhibited cells viability of HSC-T6 cells and decrease protein expression of collagen I, α-smooth muscle actin (α-SMA), tissue inhibitors of metalloproteinases I (TIMP-1) on LPS-induced HSC-T6 cells. OPC also significantly inhibited phosphorylation of LPS-stimulated phosphatidylinositol 3-kinase (PI3K), protein kinase B (Akt), extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK)...
July 7, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28690624/transcriptome-wide-identification-of-novel-uv-b-and-light-modulated-flavonol-pathway-genes-controlled-by-vvimybf1
#6
Stefan Czemmel, Janine Höll, Rodrigo Loyola, Patricio Arce-Johnson, José Antonio Alcalde, José Tomás Matus, Jochen Bogs
Flavonols constitute a group of flavonoids with important photoprotective roles in plants. In addition, flavonol content and composition greatly influences fruit quality. We previously demonstrated that the grapevine R2R3-MYB transcription factor (TF) VviMYBF1 promotes flavonol accumulation by inducing the expression of flavonol synthase (VviFLS1/VviFLS4), a key step of the initial flavonol pathway. Despite this, gene networks underlying flavonol modification in grapevine including both structural and regulatory genes remain poorly understood...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28689063/proanthocyanidins-from-uncaria-rhynchophylla-induced-apoptosis-in-mda-mb-231-breast-cancer-cells-while-enhancing-cytotoxic-effects-of-5-fluorouracil
#7
Xiao-Xin Chen, George Pak-Heng Leung, Zhang-Jin Zhang, Jian-Bo Xiao, Li-Xing Lao, Feng Feng, Judith Choi-Wo Mak, Ying Wang, Stephen Cho-Wing Sze, Kalin Yan-Bo Zhang
Breast cancer is the most frequently diagnosed cancer and cause of cancer death in women worldwide. Current treatments often result in systematic toxicity and drug resistance. Combinational use of non-toxic phytochemicals with chemotherapeutic agents to enhance the efficacy and reduce toxicity would be one promising approach. In this study, bioactive proanthocyanidins from Uncaria rhynchophylla (UPAs) were isolated and their anti-breast cancer effects alone and in combination with 5- fluorouracil (5-FU) were investigated in MDA-MB-231 breast cancer cells...
July 5, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28688843/chemical-stability-of-the-botanical-drug-substance-crofelemer-a-model-system-for-comparative-characterization-of-complex-mixture-drugs
#8
Asha Hewarathna, Olivier Mozziconacci, Maulik K Nariya, Peter A Kleindl, Jian Xiong, Adam C Fisher, Sangeeta B Joshi, C Russell Middaugh, M Laird Forrest, David B Volkin, Eric J Deeds, Christian Schöneich
As the second of a three part series of articles in this issue concerning the development of a mathematical model for comparative characterization of complex mixture drugs using Crofelemer (CF) as a model compound, this work focuses on the evaluation of the chemical stability profile of CF. CF is a biopolymer containing a mixture of proanthocyanidin oligomers which are primarily composed of gallocatechin with a small contribution from catechin. CF extracted from drug product was subjected to molecular weight-based fractionation and thiolysis...
July 5, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28677983/aronia-berry-extract-ameliorates-the-severity-of-dextran-sodium-sulfate-induced-ulcerative-colitis-in-mice
#9
Sa-Haeng Kang, Yong-Deok Jeon, Kwang-Hyun Moon, Jeong-Ho Lee, Dae-Geun Kim, Wook Kim, Hyun Myung, Jong-Sung Kim, Hyun-Ju Kim, Keuk-Soo Bang, Jong-Sik Jin
Inflammatory bowel disease, including Crohn's disease and ulcerative colitis (UC), is a group of inflammatory conditions of the colon and small intestine. UC is a chronic inflammatory disorder of the colon and rectum that includes intervals of acute exacerbation. Although recent studies have suggested that proinflammatory cytokines might have initiated the inflammatory responses in UC, its etiology remains unclear. Aronia berries are rich in dietary polyphenols such as phenolic acids, anthocyanins, flavonoids, and proanthocyanidins with various health benefits, including antioxidant, anti-inflammatory, and antiaging activities...
July 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28672844/5-3-4-dihydroxyphenyl-%C3%AE-valerolactone-a-major-microbial-metabolite-of-proanthocyanidin-attenuates-thp-1-monocyte-endothelial-adhesion
#10
Charles C Lee, Jong Hun Kim, Ji Seung Kim, Yun Sil Oh, Seung Min Han, Jung Han Yoon Park, Ki Won Lee, Chang Yong Lee
Several metabolomics of polymeric flavan-3-ols have reported that proanthocyanidins are extensively metabolized by gut microbiota. 5-(3',4'-dihydroxyphenyl)-γ-valerolactone (DHPV) has been reported to be the major microbial metabolite of proanthocyanidins. We demonstrated that DHPV has stronger prevention effect on tumor necrosis factor (TNF)-α-stimulated adhesion of THP-1 human monocytic cells to human umbilical vein endothelial cells compared to its potential precursors such as procyanidin A1, A2, B1 and B2, (+)catechin, (-)epicatechin and its microbial metabolites such as 3-(3,4-dihydroxyphenyl)propionic acid and 2-(3,4-dihydroxyphenyl)acetic acid...
June 26, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28659730/acute-selective-bioactivity-of-grape-seed-proanthocyanidins-on-enteroendocrine-secretions-in-the-gastrointestinal-tract
#11
Àngela Casanova-Martí, Joan Serrano, M Teresa Blay, Ximena Terra, Anna Ardévol, Montserrat Pinent
Background: Enteroendocrine cells respond to food components by secreting an array of hormones that regulate several functions. We have previously shown that grape seed proanthocyanidins (GSPE) modulate GLP-1 levels. Objective: To deepen on the knowledge of the mechanisms used by GSPE to increase GLP-1, and extend it to its role at modulation of other enterohormones. Design: We used an ex vivo system to test direct modulation of enterohormones; STC-1 cells to test pure phenolic compounds; and rats to test the effects at different gastrointestinal segments...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/28650150/genome-wide-association-mapping-of-seed-coat-color-in-brassica-napus
#12
Jia Wang, Xiaohua Xian, Xinfu Xu, Cunmin Qu, Kun Lu, Jiana Li, Liezhao Liu
Seed coat color is an extremely important breeding characteristic of Brassica napus. To elucidate the factors affecting the genetic architecture of seed coat color, a genome-wide association study (GWAS) of seed coat color was conducted with a diversity panel comprising 520 B. napus cultivars and inbred lines. In total, 22 single-nucleotide polymorphisms (SNPs) distributed on 7 chromosomes were found to be associated with seed coat color. The most significant SNPs were found in 2014 near Bn-scaff_15763_1-p233999, only 43...
July 5, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28648053/separation-of-ellagitannin-rich-phenolics-from-u-s-pecans-and-chinese-hickory-nuts-using-fused-core-hplc-columns-and-their-characterization
#13
Yi Gong, Ronald B Pegg
U.S. pecans and Chinese hickory nuts possess a wide array of phenolic constituents with potential health benefits including phenolic acids and proanthocyanidins. Only limited information is available, however, on their compositions. The present study optimized the separation performance and characterized the low-molecular-weight phenolic fractions of these nuts with C18 and pentafluorophenyl (PFP) fused-core LC columns by employing a kinetic approach. Although both types of reversed-phase columns demonstrated similar performance in general, the PFP column furnished greater plate numbers and superior peak shapes for the low-molecular-weight fractions as well as overall separations of ellagic acid derivatives...
July 3, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28610734/impact-of-post-harvest-ozone-treatments-on-the-skin-phenolic-extractability-of-red-winegrapes-cv-barbera-and-nebbiolo-vitis-vinifera-l
#14
Maria Alessandra Paissoni, Susana Río Segade, Simone Giacosa, Fabrizio Torchio, Francesco Cravero, Vasileios Englezos, Kalliopi Rantsiou, Cristian Carboni, Vincenzo Gerbi, Pierre-Louis Teissedre, Luca Rolle
Recently the use of ozone as sanitizing agent has been proposed on winegrapes in order to control mycobiota after harvest. The aim of this work was to investigate possible indirect physico-chemical effects of ozone treatment on berry skin phenolic composition and extractability. Vitis vinifera L. cv Nebbiolo and Barbera, chosen for their different anthocyanin profiles, were post-harvest treated for 24 and 72h with gaseous ozone (30μL/L). Skin anthocyanin and flavanol extractability was assessed during maceration (6, 24, 48, 96, 168 and 240h) using a wine-like solution...
August 2017: Food Research International
https://www.readbyqxmd.com/read/28610726/the-metabolomic-profile-of-red-non-v-vinifera-genotypes
#15
Silvia Ruocco, Marco Stefanini, Jan Stanstrup, Daniele Perenzoni, Fulvio Mattivi, Urska Vrhovsek
Wild American genotypes represent an important part of the Vitis germplasm in relation to grape improvement. Today, these genotypes are currently involved in breeding programmes in order to introgress traits resistant to pests and diseases in V. vinifera cultivars. Nevertheless, the metabolic composition of their grapes has not been widely investigated. This study aimed to explore in detail the metabolomic profile in terms of simple phenolic, proanthocyanidin, anthocyanin and lipid compounds in two hybrids and five American genotypes...
August 2017: Food Research International
https://www.readbyqxmd.com/read/28606222/association-of-flavonoid-rich-foods-and-flavonoids-with-risk-of-all-cause-mortality
#16
Kerry L Ivey, Majken K Jensen, Jonathan M Hodgson, A Heather Eliassen, Aedín Cassidy, Eric B Rimm
Flavonoids are bioactive compounds found in foods such as tea, red wine, fruits and vegetables. Higher intakes of specific flavonoids, and flavonoid-rich foods, have been linked to reduced mortality from specific vascular diseases and cancers. However, the importance of flavonoid-rich foods, and flavonoids, in preventing all-cause mortality remains uncertain. As such, we examined the association of intake of flavonoid-rich foods and flavonoids with subsequent mortality among 93 145 young and middle-aged women in the Nurses' Health Study II...
May 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28602091/assessing-spatial-variability-of-grape-skin-flavonoids-at-the-vineyard-scale-based-on-plant-water-status-mapping
#17
Luca Brillante, Johann Martínez-Luscher, Runze Yu, Cassandra M Plank, Luis Sanchez, Terrence L Bates, Charles Brenneman, Anita Oberholster, S Kaan Kurtural
Plant water stress affects grape (Vitis vinifera L. cv. Cabernet Sauvignon) berry composition and is variable in space due to variations in the physical environment at the growing site. We monitored the natural variability of grapevine water stress by stem water potential (Ψstem) and leaf gas exchange in an equi-distant grid in a commercial vineyard. Spatial differences were measured and related to topographical variation by modeling. Geospatial analysis and clustering allowed researchers to differentiate the vineyard block into two distinct zones having severe and moderate water stress where it varied by 0...
July 5, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28597005/acid-etching-with-modified-phosphoric-acid-to-increase-the-longevity-of-the-bonded-interface
#18
Alessandro D Loguercio, Pamela Malaquias, Fabiane Pereira Dos Santos, Viviane Hass, Rodrigo Stanislawczuk, Suellen Nogueira Linares Lima, Matheus Coelho Bandeca, Alessandra Reis
PURPOSE: To evaluate the effect of three phosphoric acids modified with chlorhexidine (CHX), benzalkonium chloride (BAC), or proanthocyanidins (PRO) and one conventional phosphoric acid (CON) on the immediate (24 h; IM) and 1-year composite-dentin microtensile bond strength (μTBS) and nanoleakage (NL), using an etch-and-rinse adhesive. MATERIALS AND METHODS: A flat dentin surface was exposed on 28 caries-free extracted molars, which were then randomly assigned to four groups (n = 7)...
June 8, 2017: Journal of Adhesive Dentistry
https://www.readbyqxmd.com/read/28590446/fruits-of-black-chokeberry-aronia-melanocarpa-in-the-prevention-of-chronic-diseases
#19
REVIEW
Tunde Jurikova, Jiri Mlcek, Sona Skrovankova, Daniela Sumczynski, Jiri Sochor, Irena Hlavacova, Lukas Snopek, Jana Orsavova
In recent years, growing attention has been focused on the utilization of natural sources of antioxidants in the prevention of chronic diseases. Black chokeberry (Aronia melanocarpa) represents a lesser known fruit species utilized mainly as juices, purees, jams, jellies and wine, as important food colorants or nutritional supplements. The fruit is valued as a great source of antioxidants, especially polyphenols, such as phenolic acids (neochlorogenic and chlorogenic acids) and flavonoids (anthocyanins, proanthocyanidins, flavanols and flavonols), particularly cyanidin-3-galactoside and cyanidin-3-arabinoside, as well as (-)-epicatechin units...
June 7, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28590026/efficient-approach-for-the-extraction-of-proanthocyanidins-from-cinnamomum-longepaniculatum-leaves-using-ultrasonic-irradiation-and-an-evaluation-of-their-inhibition-activity-on-digestive-enzymes-and-antioxidant-activity-in-vitro
#20
Zaizhi Liu, Kailin Mo, Shimin Fei, Yuangang Zu, Lei Yang
Proanthocyanidins were separated for the first time from Cinnamomum longepaniculatum leaves. An experiment-based extraction strategy was used to research the efficiency of an ultrasound-assisted method for proanthocyanidins extraction. The Plackett-Burman design results revealed that the ultrasonication time, ultrasonic power and liquid/solid ratio were the most significant parameters among the six variables in the extraction process. Upon further optimization of the Box-Behnken design, the optimal conditions were obtained as follows: extraction temperature, 100°C; ethanol concentration, 70%; pH 5; ultrasonication power, 660 W; ultrasonication time, 44 min; liquid/solid ratio, 20 mL/g...
June 7, 2017: Journal of Separation Science
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