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Proanthocyanidin

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https://www.readbyqxmd.com/read/29776697/cinnamtannin-b-1-a-novel-antioxidant-for-sperm-in-red-deer
#1
F Sánchez-Rubio, M R Fernández-Santos, L Castro-Vázquez, O García-Álvarez, A Maroto-Morales, A J Soler, F Martínez-Pastor, J J Garde
Cinnamtannin B-1 (CNB-1) is a naturally occurring trimeric A-type proanthocyanidin contained in several plants such as cinnamon (Cinnamomum zeylanicum). It is considered to be a potent antioxidant. The protective effect of CNB-1 against oxidative stress was assessed in red deer epididymal sperm incubated at 37 °C. Cryopreserved sperm from six stags were thawed, pooled and extended to 400 × 106 sperm/ml in BGM (bovine gamete medium). After being aliquoted, the samples were supplemented with different concentrations of CNB-1 (0, 0...
May 15, 2018: Animal Reproduction Science
https://www.readbyqxmd.com/read/29775211/proanthocyanidins-will-they-effectively-restrain-conspicuous-bacterial-strains-devolving-on-urinary-tract-infection
#2
REVIEW
Venkataseshan Jagannathan, Pragasam Viswanathan
Struvite or infection stones are one of the major clinical burdens among urinary tract infection, which occur due to the interaction between microbes and urine mineral components. Numerous urinary tract infection (UTI) causing microbes regulate through biofilm formation for survival from host defense, it is often found difficult in its eradication with simple anti-microbial agents and also the chance of recurrence and resistance development is significantly high. Cranberry consumption and maintenance of urinary tract health have been supported by clinical, epidemiological, and mechanistic studies...
May 18, 2018: Journal of Basic Microbiology
https://www.readbyqxmd.com/read/29772811/phenolic-compositions-and-antioxidant-activities-differ-significantly-among-sorghum-grains-with-different-applications
#3
Shuyu Shen, Rui Huang, Charlie Li, Wenyan Wu, Honglin Chen, John Shi, Shiguo Chen, Xingqian Ye
Sorghum grains with different applications had different phenolic profiles, which were corresponded to various antioxidant capacities. In this study, total phenolic, proanthocyanidins and flavonoids contents, as well as contents of individual phenolic compounds from sorghum grains with various applications were determined, and their antioxidant capacities were evaluated. Total phenolic contents (TPC) and total proanthocyanidins contents (TPAC) showed strong correlation with antioxidant activities ( r > 0...
May 17, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29770693/vine-shoot-tannins-effect-of-post-pruning-storage-and-toasting-treatment
#4
Cristina Cebrían-Tarancon, Rosario Sanchez-Gomez, Sergio Gómez-Alonso, Isidro Hermosin-Gutierrez, Adela Mena-Morales, Esteban García-Romero, M Rosario Salinas, Amaya Zalacain
For first time vine-shoot tannin composition was carried out by means of HPLC-DAD-ESI-MS/MS. Two vine-shoot cultivars (Airén and Cencibel) with different post-pruning storage time and submitted to a toasting process, were assayed. There was no trace of gallotannins nor ellagitannins, but a high proanthocyanidins content and a mean degree of polymerization (mDP) close to 3 was characterized. The higher concentration of proanthocyanidins corresponded to Airén after 6 months post-pruning storage and at 3 months for Cencibel...
May 17, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29765504/polyphenolic-compounds-antioxidant-and-cardioprotective-effects-of-pomace-extracts-from-feteasc%C3%A4-neagr%C3%A4-cultivar
#5
Ştefania Silvia Balea, Alina Elena Pârvu, Nastasia Pop, Fernando Zamora Marín, Marcel Pârvu
Grape pomace is a potential source of natural antioxidant agents. Phenolic compounds and antioxidant and cardioprotective properties of fresh and fermented pomace extracts obtained from Vitis vinifera L. red variety Fetească neagră grown in Romania in 2015 were investigated. Grape pomace extracts total phenolic index, total tannins, total anthocyanins, proanthocyanidins, flavan-3-ol monomers, stilbenes, and DPPH free radical scavenger were measured. The effect of a seven-day pretreatment with grape pomace extracts on the isoprenaline-induced infarct-like lesion in rats was assessed by ECG monitoring, serum levels of creatine kinase, aspartate transaminase, and alanine transaminase...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29759310/flavanols-are-potential-anti-obesity-agents-a-systematic-review-and-meta-analysis-of-controlled-clinical-trials
#6
M Akhlaghi, S Ghobadi, M Mohammad Hosseini, Z Gholami, F Mohammadian
BACKGROUND: The anti-obesity potential of flavonoids has been shown by animal and human studies. In this meta-analysis, we systematically reviewed controlled clinical trials and quantified the effects of flavonoids and flavonoid subclasses on obesity-related anthropometric measures. METHODS AND RESULTS: PubMed, EMBASE, Scopus, Web of Science, and ProQuest databases were searched to identify trials examining the effect of flavonoids on body mass index (BMI), waist circumference, and body fat percentage...
April 13, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29758419/seasonal-ionomic-and-metabolic-changes-in-aleppo-pines-growing-on-mine-tailings-under-mediterranean-semi-arid-climate
#7
Antonio López-Orenes, María C Bueso, Héctor Conesa, Antonio A Calderón, María A Ferrer
Aleppo pine is the most abundant conifer species in Mediterranean basin. Knowledge of adaptive mechanisms to cope with different environmental stresses simultaneously is necessary to improve its resilience to the predicted climatic changes and anthropogenic stressors, such as heavy metal/metal(loid)s (HMMs) pollution. Here, one year-old needles and rhizosphere soil samples from five mining and non-mining (NM) populations of Aleppo pines grown spontaneously in SE Spain were sampled in two consecutive years during spring and summer...
May 11, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29751684/polyphenolic-composition-and-antioxidant-activity-of-aqueous-and-ethanolic-extracts-from-uncaria-tomentosa-bark-and-leaves
#8
Mirtha Navarro-Hoyos, Diego Alvarado-Corella, Ileana Moreira-Gonzalez, Elizabeth Arnaez-Serrano, Maria Monagas-Juan
Uncaria tomentosa constitutes an important source of secondary metabolites with diverse biological activities mainly attributed until recently to alkaloids and triterpenes. We have previously reported for the first-time the polyphenolic profile of extracts from U. tomentosa , using a multi-step process involving organic solvents, as well as their antioxidant capacity, antimicrobial activity on aerial bacteria, and cytotoxicity on cancer cell lines. These promising results prompted the present study using food grade solvents suitable for the elaboration of commercial extracts...
May 11, 2018: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29750172/proanthocyanidins-against-oxidative-stress-from-molecular-mechanisms-to-clinical-applications
#9
REVIEW
Lingyu Yang, Dehai Xian, Xia Xiong, Rui Lai, Jing Song, Jianqiao Zhong
Proanthocyanidins (PCs) are naturally occurring polyphenolic compounds abundant in many vegetables, plant skins (rind/bark), seeds, flowers, fruits, and nuts. Numerous in vitro and in vivo studies have demonstrated myriad effects potentially beneficial to human health, such as antioxidation, anti-inflammation, immunomodulation, DNA repair, and antitumor activity. Accumulation of prooxidants such as reactive oxygen species (ROS) exceeding cellular antioxidant capacity results in oxidative stress (OS), which can damage macromolecules (DNA, lipids, and proteins), organelles (membranes and mitochondria), and whole tissues...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29748512/protective-effect-of-highly-polymeric-a-type-proanthocyanidins-from-seed-shells-of-japanese-horse-chestnut-aesculus-turbinata-blume-against-light-induced-oxidative-damage-in-rat-retina
#10
Tomoe Ishihara, Sachiko Kaidzu, Hideto Kimura, Yasurou Koyama, Yotaro Matsuoka, Akihiro Ohira
Retinal tissue is exposed to oxidative stress caused by visible light. Light-damaged rat used in age-related macular degeneration (AMD) studies clarified that antioxidants decrease retinal light damage. Albino rats were exposed to 5000 Lux light for 12 h with oral administration of the polyphenolic compounds fraction (PF) from the seed shells of Japanese horse chestnut (30 mg/kg, 100 mg/kg, and 300 mg/kg body weight: BW). To evaluate the protective effects against light damage, electroretinograms (ERGs), the outer nuclear layer (ONL) thickness, the antioxidant activity of plasma, oxidized retinal lipids, and the detection of apoptosis were examined...
May 10, 2018: Nutrients
https://www.readbyqxmd.com/read/29744882/evaluation-of-cytotoxic-immunomodulatory-and-antibacterial-activities-of-aqueous-extract-from-leaves-of-conocarpus-erectus-linnaeus-combretaceae
#11
Dayane Kelly Dias do Nascimento Santos, Vanessa Silva de Almeida, Daniel Rodrigo Cavalcante de Araujo, Wolfgang Harand, Ana Karine de Araújo Soares, Leyllane Rafael Moreira, Virgínia Maria Barros de Lorena, Lucimeri Paulino Machado Magalhães, Rafael Matos Ximenes, Kêsia Xisto da Fonseca Ribeiro de Sena, Cristiane Moutinho Lagos de Melo, Thiago Henrique Napoleão, Cláudia Sampaio de Andrade Lima, Ricardo Yara, Jeymesson Raphael Cardoso Vieira
OBJECTIVES: This work evaluated the antibacterial activity, cytotoxicity and immunomodulatory effect on human peripheral blood mononuclear cells (PBMCs) promoted by aqueous extract from Conocarpus erectus leaves (AELCe). METHODS: The extract was characterized by thin layer chromatography and ultraperformance liquid chromatography coupled to mass spectrometry (UPLC-MS). Cytotoxicity of AELCe (6.25-50 μg/ml) was investigated using annexin V and propidium iodide. Cytokine and nitric oxide levels in PBMCs culture supernatants exposed or not to AELCe (12...
May 10, 2018: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/29743442/fluoride-induced-iron-overload-contributes-to-hepatic-oxidative-damage-in-mouse-and-the-protective-role-of-grape-seed-proanthocyanidin-extract
#12
Qiang Niu, Ping He, Shangzhi Xu, Ruling Ma, Yusong Ding, Lati Mu, Shugang Li
Emerging evidence has demonstrated that iron overload plays an important role in oxidative stress in the liver. This study aimed to explore whether fluoride-induced hepatic oxidative stress is associated with iron overload and whether grape seed proanthocyanidin extract (GSPE) alleviates oxidative stress by reducing iron overload. Forty Kunming male mice were randomly divided into 4 groups and treated for 5 weeks with distilled water (control), sodium fluoride (NaF) (100 mg/L), GSPE (400 mg/kg bw), or NaF (100 mg/L) + GSPE (400 mg/kg bw)...
2018: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/29737417/occurrence-and-tolerance-mechanisms-of-seed-cracking-under-low-temperatures-in-soybean-glycine-max
#13
Mineo Senda, Michio Kawasaki, Miho Hiraoka, Kazuki Yamashita, Hayato Maeda, Naoya Yamaguchi
In soybean, occurrence of, or tolerance to, seed cracking under low temperatures may be related to the presence or absence, respectively, of proanthocyanidin accumulation in the seed coat dorsal region. Soybean seeds sometimes undergo cracking during low temperatures in summer. In this study, we focused on the occurrence and tolerance mechanisms of low-temperature-induced seed cracking in the sensitive yellow soybean cultivar Yukihomare and the tolerant yellow soybean breeding line Toiku 248. Yukihomare exhibited seed cracking when subjected to a 21-day low-temperature treatment from 10 days after flowering...
May 8, 2018: Planta
https://www.readbyqxmd.com/read/29727860/comparative-transcriptome-analysis-of-genes-involved-in-anthocyanin-synthesis-in-blueberry
#14
Yang Lin, Yuehua Wang, Bin Li, Hui Tan, Dongnan Li, Li Li, Xuan Liu, Jichen Han, Xianjun Meng
Blueberry (Vaccinium, family Ericaceae) is well known for its strong antioxidant properties and abundant active ingredients including anthocyanins, flavonols, and proanthocyanidins. In this study, variations in anthocyanin and phenolic compounds content in Bluecrop and Northblue blueberry cultivar fruits were studied, and comparative transcriptome analysis was performed to analyze differences in the molecular mechanisms of anthocyanin biosynthesis. A total of 13 799 unique genes were identified by differential expression analysis, and further subjected to GO classification and pathway enrichment...
April 26, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29727782/determination-of-flavanols-by-liquid-chromatography-with-fluorescence-detection-application-to-the-characterization-of-cranberry-based-pharmaceuticals-through-profiling-and-fingerprinting-approaches
#15
Inal Bakhytkyzy, Oscar Nuñez, Javier Saurina
In this work, a new method based on reversed-phase high-performance liquid chromatography (HPLC) with fluorescence detection (FLD) was established for the determination of catechins and related oligomeric proanthocyanidins (PACs) in cranberry-based pharmaceuticals. Compounds were recovered by liquid extraction using methanol/water/hydrochloric acid (60:39:1, v:v:v) as the extraction solvent. The chromatographic separation was carried out using a core-shell C18 column under an elution program based on 0.1% formic acid in water and methanol as the components of the mobile phase...
April 24, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29725928/chemical-characterization-and-release-of-polyphenols-from-pecan-nut-shell-carya-illinoinensis-wangenh-c-koch-in-zein-microparticles-for-bioactive-applications
#16
Itamara Kureck, Priscila de Brito Policarpi, Isabela Maia Toaldo, Matheus Vinícius de Oliveira Brisola Maciel, Marilde T Bordignon-Luiz, Pedro Luiz Manique Barreto, Jane Mara Block
The pecan nut [Carya illinoinensis (Wangenh) C. Koch] is a natural source of polyphenols with antioxidant properties. In this study, the encapsulation of aqueous and hydroalcoholic extracts of pecan nut shell were evaluated for the release of bioactive compounds and antioxidant potential in order to explore food applications using zein as encapsulating agent. The extracts showed high contents of total phenolics, condensed tannins and high antioxidant activity. Concentrations of proanthocyanidins were 9-fold higher in hydroalcoholic extracts...
May 3, 2018: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/29725583/evaluation-of-the-systemic-toxicity-and-mutagenicity-of-oligopin%C3%A2-procyanidolic-oligomers-opc-extracted-from-french-maritime-pine-bark-extract
#17
L Segal, M G Penman, Y Piriou
The potential systemic toxicity of Oligopin®, a French Maritime Pine Bark extract (FMPBE) rich in procyanidolic oligomers, was evaluated in an acute oral limit test and a 90-day repeated dose oral toxicity study with Sprague Dawley rats. The potential mutagenicity was assessed in a bacterial reverse mutation assay and in vitro mammalian chromosome aberration assay with human lymphocytes. The results indicate that Oligopin® was nongenotoxic in both bacterial and human cell assays, was not acutely toxic via oral administration at up to 2000 mg/kg and was well tolerated following 90 days of oral administration to SD rats, with a no observed adverse effect level of 1000 mg/kg/day...
2018: Toxicology Reports
https://www.readbyqxmd.com/read/29720842/-in-vitro-antioxidant-potentials-of-cyperus-rotundus-l-rhizome-extracts-and-their-phytochemical-analysis
#18
Arunagiri Kamala, Sushil Kumar Middha, Chitra Gopinath, H S Sindhura, Chandrakant S Karigar
Background: Cyperus rotundus L. (family Cyperaceae), native to India, is a multivalent medicinal plant widely used in conventional medicine. The research reports on bioactive components from C. rotundus L. are scanty. Objective: The objective of the study was to optimize the best solvent system and bioprospect the possible phytochemicals in C. rotundus L. rhizome (CRR). Materials and Methods: The phytochemicals were extracted from the rhizomes of C...
April 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29720831/phytochemical-composition-and-antioxidant-activities-of-dianthus-thunbergii-hooper-and-hypoxis-argentea-harv-ex-baker-plants-used-for-the-management-of-diabetes-mellitus-in-eastern-cape-south-africa
#19
Akinleye Stephen Akinrinde, Anthony Jide Afolayan, Graeme Bradley
Background: Inhabitants of the Eastern Cape Province of South Africa use the roots of Dianthus thunbergii and corms of Hypoxis argentea to treat diabetes mellitus and other ailments. Objective: The objective of this study was to analyze the phytochemical composition and antioxidant activities of the aqueous and ethanol extracts of the roots and corms of two plants. Materials and Methods: Total phenolics, flavonoids, flavonols, proanthocyanidins, tannins, and alkaloids were determined by standard methods...
April 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29716590/in-vitro-effects-of-aqueous-extract-from-maytenus-senegalensis-lam-exell-stem-bark-on-egg-hatching-larval-migration-and-adult-worms-of-haemonchus-contortus
#20
Calvin Bogning Zangueu, Abiodoun Pascal Olounlade, Marlyse Ossokomack, Yolande Noelle Nangue Djouatsa, Goue Géorcelin Alowanou, Anatole Guy Blaise Azebaze, Eulogio José Llorent-Martínez, Maria Luisa Fernández de Córdova, Alain Bertrand Dongmo, Mawulé Sylvie Hounzangbe-Adote
BACKGROUND: Maytenus senegalensis is a common shrub which is scattered in tropical Africa. Different parts of this plant have been reported to be useful in traditional medicine against gastrointestinal disorders and intestinal worms. This study evaluated the anthelmintic activity of the aqueous stem bark extract of M. senegalensis using egg hatch assay (EHA), larval migration inhibition assay (LMIA) and adult worms' motility inhibition assay (AMIA). RESULTS: On EHA, the extract concentrations tested resulted in a significant (p < 0...
May 2, 2018: BMC Veterinary Research
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