keyword
MENU ▼
Read by QxMD icon Read
search

Proanthocyanidin

keyword
https://www.readbyqxmd.com/read/27905107/co-operative-suppression-of-inflammatory-responses-in-human-dendritic-cells-by-plant-proanthocyanidins-and-products-from-the-parasitic-nematode-trichuris-suis
#1
Andrew R Williams, Elsenoor J Klaver, Lisa C Laan, Aina Ramsay, Christos Fryganas, Rolf Difborg, Helene Kringel, Jess D Reed, Irene Mueller-Harvey, Søren Skov, Irma van Die, Stig M Thamsborg
Interactions between dendritic cells (DCs) and environmental, dietary and pathogen antigens play a key role in immune homeostasis and regulation of inflammation. Dietary polyphenols such as proanthocyanidins (PAC) may reduce inflammation, and we therefore hypothesized that PAC may suppress lipopolysaccharide (LPS) -induced responses in human DCs and subsequent T helper type 1 (Th1) -type responses in naive T cells. Moreover, we proposed that, because DCs are likely to be exposed to multiple stimuli, the activity of PAC may synergise with other bioactive molecules that have anti-inflammatory activity, e...
November 7, 2016: Immunology
https://www.readbyqxmd.com/read/27904388/content-of-total-phenolics-flavan-3-ols-and-proanthocyanidins-oxidative-stability-and-antioxidant-capacity-of-chocolate-during-storage
#2
Jovanka Laličić-Petronijević, Draženka Komes, Stanislava Gorjanović, Ana Belščak-Cvitanović, Lato Pezo, Ferenc Pastor, Sanja Ostojić, Jovanka Popov-Raljić, Desanka Sužnjević
Antioxidant (AO) capacity of chocolates with 27, 44 and 75% cocoa was assessed after production and during twelve months of storage by direct current (DC) polarographic assay, based on the decrease of anodic current caused by the formation of hydroxo-perhydroxyl mercury(II) complex (HPMC) in alkaline solutions of hydrogen peroxide at potentials of mercury oxidation, and two spectrophotometric assays. Relative antioxidant capacity index (RACI) was calculated by taking the average value of the AO assay (the sample mass in all assays was identical)...
March 2016: Food Technology and Biotechnology
https://www.readbyqxmd.com/read/27897996/in-vitro-chemopreventive-properties-of-green-tea-rooibos-and-honeybush-extracts-in-skin-cells
#3
Tandeka U Magcwebeba, Pieter Swart, Sonja Swanevelder, Elizabeth Joubert, Wentzel C A Gelderblom
The chemopreventive properties of the herbal teas rooibos (Aspalathus linearis) and honeybush (Cyclopia spp.) have been demonstrated on mouse skin in vivo but the underlying mechanisms are not clear. The aim of the current study was to determine the anti-proliferative and pro-apoptotic activity of methanol and aqueous extracts of rooibos and two Cyclopia species in different skin cells, using green tea (Camellia sinensis) as a benchmark. Extracts were also characterised for their major individual polyphenols by high performance liquid chromatography and spectroscopically for the total polyphenol (TP) groups...
November 25, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27889390/safety-assessment-of-4-week-oral-intake-of-proanthocyanidin-rich-grape-seed-extract-in-healthy-subjects
#4
Atsushi Sano
A clinical study was conducted to assess the safety and tolerability of oral doses of proanthocyanidin-rich grape seed extract (GSE) in healthy Japanese adult volunteers. In an open-label, 4-week toxicity test, 29 subjects daily received 1,000, 1,500, or 2,500 mg GSE orally. Serum Fe levels of two subjects in the 2,500 mg GSE group decreased to 61 and 60 μg/100 mL from 205 and 182 μg/100 mL at baseline respectively, at second week of GSE consumption; these values are low but within the normal range for the Japanese population...
November 23, 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27887737/polyphenolic-diversity-and-characterization-in-the-red-purple-berries-of-east-asian-wild-vitis-species
#5
Kazuya Koyama, Hiroshi Kamigakiuchi, Kazuhiro Iwashita, Ryosuke Mochioka, Nami Goto-Yamamoto
Grapes (Vitis spp.) produce diverse polyphenolic compounds, which are phytochemicals that contribute to human health. In this study, the polyphenolic profiles of the red-purple berries of two wild grape species native to Japan, Vitis ficifolia and V. coignetiae, and their interspecific hybrid cultivars were investigated and compared with the profiles of V. vinifera and V. × labruscana cultivars. Proanthocyanidins (PAs) were present at lower concentrations in both skins and seeds of wild grape species and their hybrid cultivars than those in V...
November 22, 2016: Phytochemistry
https://www.readbyqxmd.com/read/27886147/emerging-phytochemicals-for-the-prevention-and-treatment-of-head-and-neck-cancer
#6
REVIEW
Santosh K Katiyar
Despite the development of more advanced medical therapies, cancer management remains a problem. Head and neck squamous cell carcinoma (HNSCC) is a particularly challenging malignancy and requires more effective treatment strategies and a reduction in the debilitating morbidities associated with the therapies. Phytochemicals have long been used in ancient systems of medicine, and non-toxic phytochemicals are being considered as new options for the effective management of cancer. Here, we discuss the growth inhibitory and anti-cell migratory actions of proanthocyanidins from grape seeds (GSPs), polyphenols in green tea and honokiol, derived from the Magnolia species...
November 24, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27880936/dietary-grape-seed-proanthocyanidins-gsps-improve-weaned-intestinal-microbiota-and-mucosal-barrier-using-a-piglet-model
#7
Meng Han, Peixia Song, Chang Huang, Arash Rezaei, Shabnam Farrar, Michael A Brown, Xi Ma
Proanthocyanidins have been suggested as an effective antibiotic alternative, however their mechanisms are still unknown. The present study investigated the effects of grape seed proanthocyanidins on gut microbiota and mucosal barrier using a weaned piglet model in comparison with colistin. Piglets weaned at 28 day were randomly assigned to four groups treated with a control ration, or supplemented with 250 mg/kg proanthocyanidins, kitasamycin/colistin, or 250 mg/kg proanthocyanidins and half-dose antibiotics, respectively...
November 18, 2016: Oncotarget
https://www.readbyqxmd.com/read/27874097/molecular-insight-into-affinities-of-gallated-and-nongallated-proanthocyanidins-dimers-to-lipid-bilayers
#8
Wei Zhu, Le Xiong, Jinming Peng, Xiangyi Deng, Jun Gao, Chun-Mei Li
Experimental studies have proved the beneficial effects of proanthocyanidins (Pas) relating to interaction with the cell membrane. But the detailed mechanisms and structure-function relationship was unclear. In present study, molecular dynamics (MD) simulations were used to study the interactions of four PA dimers with a lipid bilayer composed of 1:1 mixed 1-palmitoyl-2-oleoyl phosphatidylcholine (POPC) and 1-palmitoyl-2-oleoyl phosphatidylethanolamine (POPE). The results showed that the gallated PA dimers had much higher affinities to the bilayer with lower binding free energies compared with nongallated PA dimers...
November 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27873332/monitoring-of-compositional-changes-during-berry-ripening-in-grape-seed-extracts-of-cv-sangiovese-vitis-vinifera-l
#9
Giuseppe Bombai, Federica Pasini, Vito Verardo, Onur Sevindik, Michele Di Foggia, Paola Tessarin, Anna Maria Bregoli, Paola Taddei, Maria Fiorenza Caboni, Adamo Domenico Rombolà
BACKGROUND: Seed oil and flours have been attracting the interest of researchers and industry, since they contain various bioactive components. We monitored the effects of ripening on lipids, flavan-3-ols, proanthocyanidins and tocols concentration in seed extracts from organically-cultivated cv. Sangiovese vines. RESULTS: Linoleic acid was the most abundant fatty acid, followed by oleic, palmitic and stearic acids. The tocols detected were α-tocopherol, α-tocotrienol and γ-tocotrienol...
November 21, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27869786/a-role-for-leucoanthocyanidin-reductase-in-the-extension-of-proanthocyanidins
#10
Chenggang Liu, Xiaoqiang Wang, Vladimir Shulaev, Richard A Dixon
Proanthocyanidins (PAs) are the second most abundant plant polyphenolic compounds after lignin. PAs affect taste, mouth feel and astringency of many fruits, wines and beverages(1,2), have been associated with reduced risks of cardiovascular disease, cancer and Alzheimer's disease(3-5), can improve nutrition and prevent bloat in ruminant animals(6) and enhance soil nitrogen retention(7). PAs are oligomers and polymers of flavan-3-ols, primarily (-)-epicatechin and (+)-catechin, but the mechanism by which the monomers polymerize and become insoluble is currently unknown...
November 21, 2016: Nature Plants
https://www.readbyqxmd.com/read/27866177/cranberries-for-preventing-recurrent-urinary-tract-infections-in-uncircumcised-boys
#11
Kong-Sang Wan, Chih-Kuang Liu, Wen-Kai Lee, Ming-Chung Ko, Che-Sheng Huang
Background • Highly concentrated cranberry juice has long been considered to have protective properties against urinary tract infections (UTIs), on the basis of its content of cranberry proanthocyanidins, with A-type interflavan bonds. Objective • This study intended to evaluate the benefits of a highly concentrated cranberry juice for the prevention of repeated episodes of UTI in uncircumcised boys. Design • The study was a randomized, controlled trial. Setting • The study took place at Taipei City Hospital, Renai and Zhongxing Branches (Taipei City, Taiwan)...
November 2016: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/27863453/a-new-class-of-hepatitis-b-and-d-virus-entry-inhibitors-proanthocyanidin-and-its-analogs-that-directly-act-on-the-viral-large-surface-proteins
#12
Senko Tsukuda, Koichi Watashi, Taichi Hojima, Masanori Isogawa, Masashi Iwamoto, Katsumi Omagari, Ryosuke Suzuki, Hideki Aizaki, Soichi Kojima, Masaya Sugiyama, Akiko Saito, Yasuhito Tanaka, Masashi Mizokami, Camille Sureau, Takaji Wakita
: Introduction of direct acting antivirals against hepatitis C virus (HCV) has provided a revolutionary improvement in the treatment outcome. In contrast to HCV, however, the strategy for developing new antiviral agents against hepatitis B virus (HBV), especially viral-targeting compounds, is limited since HBV requires only four viral genes for its efficient replication/infection. Here, we identify an oligomeric flavonoid, proanthocyanidin (PAC) and its analogs, which inhibit HBV entry into host cells by targeting the HBV large surface protein (LHBs)...
November 18, 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/27856170/antifungal-activity-of-acetone-extracts-from-punica-granatum-l-quercus-suber-l-%C3%A2-and-vicia-faba-l
#13
S Akroum
Human and animal mycoses become more frequent and more resistant to traditional treatments. In this work, we tested the in vitro antifungal activity of acetonic extracts of Punica granatum L., Quercus suber L. and Vicia faba L. against seven pathogen fungi and the in vivo antifungal activity against Candida albicans and Trichophyton mentagrophytes. The phytochemical screening was also carried out and showed that the extracts contained mainly proanthocyanidins. Other polyphenols were also present but in low quantity...
November 14, 2016: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/27852122/pinus-massoniana-bark-extract-structure-activity-relationship-and-biomedical-potentials
#14
Jiao Feng, Xiao-Lu Zhang, Ying-Ya Li, Ying-Yu Cui, Yi-Han Chen
Proanthocyanidins (PAs) belong to the condensed tannin subfamily of natural flavonoids. Recent studies have shown that the main bioactive compounds of Pinus massoniana bark extract (PMBE) are PAs, especially the proanthocyanidins B series, which play important roles in cell cycle arrest, apoptosis induction and migration inhibition of cancer cells in vivo and in vitro. PA-Bs are mixtures of oligomers and polymers composed of flavan-3-ol, and the relationship between their structure and corresponding biomedical potentials is summarized in this paper...
November 16, 2016: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/27847974/liquid-chromatographic-electrospray-ionization-quadrupole-time-of-flight-tandem-mass-spectrometric-study-of-polyphenolic-composition-of-different-vaccinium-berry-species-and-their-comparative-evaluation
#15
Claudia Ancillotti, Lorenzo Ciofi, Daniele Rossini, Ugo Chiuminatto, Jianru Stahl-Zeng, Serena Orlandini, Sandra Furlanetto, Massimo Del Bubba
Ultra-high-performance liquid chromatography coupled with high-resolution quadrupole-time of flight mass spectrometry with both negative and positive ionization was used for comprehensively investigating the phenolic and polyphenolic compounds in berries from three spontaneous or cultivated Vaccinium species (i.e., Vaccinium myrtillus, Vaccinium uliginosum subsp. gaultherioides, and Vaccinium corymbosum). More than 200 analytes, among phenolic and polyphenolic compounds belonging to the classes of anthocyanins, monomeric and oligomeric flavonols, flavanols, dihydrochalcones, phenolic acids, together with other polyphenolic compounds of mixed structural characteristics, were identified...
November 15, 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27847751/effects-of-proanthocyanidin-a-crosslinking-agent-on-physical-and-biological-properties-of-collagen-hydrogel-scaffold
#16
Yoorina Choi, Hee-Jin Kim, Kyung-San Min
OBJECTIVES: The purpose of the present study was to evaluate the effects of proanthocyanidin (PAC), a crosslinking agent, on the physical properties of a collagen hydrogel and the behavior of human periodontal ligament cells (hPDLCs) cultured in the scaffold. MATERIALS AND METHODS: Viability of hPDLCs treated with PAC was measured using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The physical properties of PAC treated collagen hydrogel scaffold were evaluated by the measurement of setting time, surface roughness, and differential scanning calorimetry (DSC)...
November 2016: Restorative Dentistry & Endodontics
https://www.readbyqxmd.com/read/27805317/fruit-and-vegetables-consumption-is-directly-associated-to-survival-after-prostate-cancer
#17
Martina Taborelli, Jerry Polesel, Maria Parpinel, Carmen Stocco, Silvia Birri, Diego Serraino, Antonella Zucchetto
SCOPE: Since the evidence on the role of diet on prostate cancer (PCa) prognosis is still controversial, we evaluated the long-term effects of fruit and vegetables consumption on survival after PCa. METHODS AND RESULTS: A retrospective cohort study included 777 men with PCa diagnosed between 1995 and 2002 in north-eastern Italy and followed-up to 2013. A validated food-frequency questionnaire assessed the usual diet in the two years before PCa diagnosis, including detailed fruit and vegetables consumption...
November 2, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27803764/the-chemical-profile-of-senna-velutina-leaves-and-their-antioxidant-and-cytotoxic-effects
#18
Jaqueline Ferreira Campos, David Tsuyoshi Hiramatsu de Castro, Marcio José Damião, Heron F Vieira Torquato, Edgar J Paredes-Gamero, Carlos Alexandre Carollo, Leticia M Estevinho, Kely de Picoli Souza, Edson Lucas Dos Santos
Natural products can be a source of biomolecules with antioxidant activity which are able to prevent oxidative stress-induced diseases and show antitumor activity, making them important sources of new anticancer drug prototypes. In this context, this study aimed to analyze the chemical composition of an ethanol extract of Senna velutina leaves and to assess its antioxidant and cytotoxic activities in leukemic cells. The antioxidant properties were evaluated using a DPPH free radical scavenging assay and by examining the extract's inhibition of AAPH-induced lipid peroxidation in human erythrocytes...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27791455/in-vitro-and-in-silico-interaction-of-porcine-%C3%AE-amylase-with-vicia-faba-crude-seed-extract-and-evaluation-of-antidiabetic-activity
#19
Dhiraj Kumar Choudhary, Abha Mishra
Diabetes mellitus is a group of metabolic disorder of glucose metabolism. The proper management of blood glucose level is an indicator in the treatment of this complex pathology. The aim of the present study was to evaluate the inhibitory potential of Vicia faba crude seed extracts on the activities of α-amylase. Phytochemical screening, FTIR and HPLC analysis confirmed the presence of a phenolic compound with percentage yield of 9.87% in the acetone extract. Acetone extract of seed had highest inhibitory potential against porcine α-amylase (IC50 value of 2...
October 28, 2016: Bioengineered
https://www.readbyqxmd.com/read/27790222/transcriptome-analysis-of-a-new-peanut-seed-coat-mutant-for-the-physiological-regulatory-mechanism-involved-in-seed-coat-cracking-and-pigmentation
#20
Liyun Wan, Bei Li, Manish K Pandey, Yanshan Wu, Yong Lei, Liying Yan, Xiaofeng Dai, Huifang Jiang, Juncheng Zhang, Guo Wei, Rajeev K Varshney, Boshou Liao
Seed-coat cracking and undesirable color of seed coat highly affects external appearance and commercial value of peanuts (Arachis hypogaea L.). With an objective to find genetic solution to the above problems, a peanut mutant with cracking and brown colored seed coat (testa) was identified from an EMS treated mutant population and designated as "peanut seed coat crack and brown color mutant line (pscb)." The seed coat weight of the mutant was almost twice of the wild type, and the germination time was significantly shorter than wild type...
2016: Frontiers in Plant Science
keyword
keyword
63168
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"