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Immunometabolism

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https://www.readbyqxmd.com/read/28985035/tumor-associated-myeloid-cells-new-understandings-on-their-metabolic-regulation-and-their-influence-in-cancer-immunotherapy
#1
REVIEW
Chiara Porta, Antonio Sica, Elena Riboldi
Tumor-associated myeloid cells (TAMCs), mainly represented by tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs), can promote tumor growth directly, by favouring tumor cell proliferation and survival, and indirectly, by creating an immunosuppressive microenvironment. Myeloid cells are characterized by an extreme phenotypical and functional plasticity. Immunometabolism is now emerging as a crucial aspect of TAMCs skewing towards pro-tumoral activities. The metabolic re-education of myeloid cells is a new strategy to boost their anti-tumor effector functions...
October 6, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28978222/the-eicosanoids-redox-regulated-lipid-mediators-in-immunometabolic-disorders
#2
Ana Carolina Araujo, Craig E Wheelock, Jesper Z Haeggström
SIGNIFICANCE: The oxidation of arachidonic acid via cyclooxygenase and lipoxygenase activity to produce eicosanoids during inflammation is a well-known biosynthetic pathway. These lipid mediators are involved in fever, pain and thrombosis and are generated from a variety of cell types as well as through interactions between immune cells and epithelial/endothelial cells. Metabolic disorders including hyperlipidemia, hypertension, and diabetes are associated with chronic low-grade inflammation, impacting the immune system and promoting a variety of chronic diseases...
October 5, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28977210/the-role-of-moderate-to-vigorous-physical-activity-in-mediating-the-relationship-between-central-adiposity-and-immunometabolic-profile-in-postmenopausal-women
#3
Tiego A Diniz, Fabricio E Rossi, Loreana S Silveira, Lucas Melo Neves, Ana Claudia de Souza Fortaleza, Diego G D Christofaro, Fabio S Lira, Ismael F Freitas-Junior
OBJECTIVES: To analyze the role of moderate-to-vigorous physical activity (MVPA) in mediating the relationship between central adiposity and immune and metabolic profile in postmenopausal women. MATERIALS AND METHODS: Cross-sectional study comprising 49 postmenopausal women (aged 59.26 ± 8.32 years) without regular physical exercise practice. Body composition was measured by dual-energy X-ray absorptiometry. Fasting blood samples were collected for assessment of nonesterified fatty acids, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), adiponectin, insulin and estimation of insulin resistance (HOMA-IR)...
July 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28971272/monocyte-and-macrophage-immunometabolism-in-atherosclerosis
#4
REVIEW
Laszlo Groh, Samuel T Keating, Leo A B Joosten, Mihai G Netea, Niels P Riksen
Atherosclerosis is characterized by chronic low grade inflammation of arteries that results in the development of lipid dense plaques. Chronic inflammation induced by Western-type diet is associated with the risk of developing atherosclerosis, and new insights shed light on the importance of metabolic and functional reprogramming in monocytes and macrophages for progression of atherosclerosis. This review aims to provide an overview of our current understanding into how the metabolic reprogramming of glucose, cholesterol, fatty acid, and amino acid metabolism in macrophages contributes to inflammation during atherosclerosis...
October 2, 2017: Seminars in Immunopathology
https://www.readbyqxmd.com/read/28954222/lipoprotein-lipase-maintains-microglial-innate-immunity-in-obesity
#5
Yuanqing Gao, Andrés Vidal-Itriago, Martin J Kalsbeek, Clarita Layritz, Cristina García-Cáceres, Robby Zachariah Tom, Thomas O Eichmann, Frédéric M Vaz, Riekelt H Houtkooper, Nicole van der Wel, Arthur J Verhoeven, Jie Yan, Andries Kalsbeek, Robert H Eckel, Susanna M Hofmann, Chun-Xia Yi
Consumption of a hypercaloric diet upregulates microglial innate immune reactivity along with a higher expression of lipoprotein lipase (Lpl) within the reactive microglia in the mouse brain. Here, we show that knockdown of the Lpl gene specifically in microglia resulted in deficient microglial uptake of lipid, mitochondrial fuel utilization shifting to glutamine, and significantly decreased immune reactivity. Mice with knockdown of the Lpl gene in microglia gained more body weight than control mice on a high-carbohydrate high-fat (HCHF) diet...
September 26, 2017: Cell Reports
https://www.readbyqxmd.com/read/28953873/inflammasome-driven-catecholamine-catabolism-in-macrophages-blunts-lipolysis-during-ageing
#6
Christina D Camell, Jil Sander, Olga Spadaro, Aileen Lee, Kim Y Nguyen, Allison Wing, Emily L Goldberg, Yun-Hee Youm, Chester W Brown, John Elsworth, Matthew S Rodeheffer, Joachim L Schultze, Vishwa D Dixit
Catecholamine-induced lipolysis, the first step in the generation of energy substrates by the hydrolysis of triglycerides, declines with age. The defect in the mobilization of free fatty acids in the elderly is accompanied by increased visceral adiposity, lower exercise capacity, failure to maintain core body temperature during cold stress, and reduced ability to survive starvation. Although catecholamine signalling in adipocytes is normal in the elderly, how lipolysis is impaired in ageing remains unknown...
October 5, 2017: Nature
https://www.readbyqxmd.com/read/28943448/molecular-integration-of-incretin-and-glucocorticoid-action-reverses-immunometabolic-dysfunction-and-obesity
#7
Carmelo Quarta, Christoffer Clemmensen, Zhimeng Zhu, Bin Yang, Sini S Joseph, Dominik Lutter, Chun-Xia Yi, Elisabeth Graf, Cristina García-Cáceres, Beata Legutko, Katrin Fischer, Robert Brommage, Philippe Zizzari, Bernardo S Franklin, Martin Krueger, Marco Koch, Sabine Vettorazzi, Pengyun Li, Susanna M Hofmann, Mostafa Bakhti, Aimée Bastidas-Ponce, Heiko Lickert, Tim M Strom, Valerie Gailus-Durner, Ingo Bechmann, Diego Perez-Tilve, Jan Tuckermann, Martin Hrabě de Angelis, Darleen Sandoval, Daniela Cota, Eicke Latz, Randy J Seeley, Timo D Müller, Richard D DiMarchi, Brian Finan, Matthias H Tschöp
Chronic inflammation has been proposed to contribute to the pathogenesis of diet-induced obesity. However, scarce therapeutic options are available to treat obesity and the associated immunometabolic complications. Glucocorticoids are routinely employed for the management of inflammatory diseases, but their pleiotropic nature leads to detrimental metabolic side effects. We developed a glucagon-like peptide-1 (GLP-1)-dexamethasone co-agonist in which GLP-1 selectively delivers dexamethasone to GLP-1 receptor-expressing cells...
October 3, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28930796/navigating-t-cell-immunometabolism-in-transplantation
#8
Naoki Tanimine, Laurence A Turka, Bhavana Priyadharshini
Recently, a new discipline termed "immunometabolism" has transformed the field of immunology. It encompasses the study of the intrinsic metabolic pathways of different immune subsets and their impact on cellular fate and function. For instance, broadly speaking, pro-inflammatory cells depend upon glycolysis and glutamine oxidation while cells involved in anti-inflammatory response such as Foxp3+ regulatory T cells (Tregs) utilize predominantly fatty acid oxidation. However, while a useful paradigm, this actually is a reductionist view and the engagement of these metabolic pathways is not mutually exclusive between these subsets...
September 19, 2017: Transplantation
https://www.readbyqxmd.com/read/28930657/foundations-of-immunometabolism-and-implications-for-metabolic-health-and-disease
#9
REVIEW
Gökhan S Hotamisligil
Highly ordered interactions between immune and metabolic responses are evolutionarily conserved and paramount for tissue and organismal health. Disruption of these interactions underlies the emergence of many pathologies, particularly chronic non-communicable diseases such as obesity and diabetes. Here, we examine decades of research identifying the complex immunometabolic signaling networks and the cellular and molecular events that occur in the setting of altered nutrient and energy exposures and offer a historical perspective...
September 19, 2017: Immunity
https://www.readbyqxmd.com/read/28891325/epigenetics-and-immunometabolism-in-diabetes-and-aging
#10
Tomasz J Guzik, Francesco Cosentino
SIGNIFICANCE: A strong relationship between hyperglycemia, impaired insulin pathway and cardiovascular disease in type 2 diabetes (T2D) is linked to oxidative stress and inflammation. Immunometabolic pathways link these pathogenic processes and pose important potential therapeutic targets. Recent Advances: The link between immunity and metabolism is bi-directional and includes the role of inflammation in the pathogenesis of metabolic disorders such as T2D, obesity, metabolic syndrome and hypertension as well as the role of metabolic factors in regulation of immune cell functions...
September 11, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28887543/the-oxidative-state-of-cysteine-thiol-144-regulates-the-sirt6-glucose-homeostat
#11
David Long, Hanzhi Wu, Allen W Tsang, Leslie B Poole, Barbara K Yoza, Xianfeng Wang, Vidula Vachharajani, Cristina M Furdui, Charles E McCall
Control of glucose homeostasis plays a critical role in health and lifespan and its dysregulation contributes to inflammation, cancer and aging. NAD + dependent Sirtuin 6 (SIRT6) is a glucose homeostasis regulator in animals and humans and its regulation at the molecular level is unknown. Here, we report that a cysteine thiol redox sensor contributes to the role of SIRT6 in controlling glucose homeostasis. Sulfenylation of SIRT6 occurs in THP1 cells and primary human promonocytes during inflammation and in splenocytes from mice with sepsis...
September 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28877980/nad-metabolism-fuels-human-and-mouse-intestinal-inflammation
#12
Romana R Gerner, Victoria Klepsch, Sophie Macheiner, Kathrin Arnhard, Timon E Adolph, Christoph Grander, Verena Wieser, Alexandra Pfister, Patrizia Moser, Natascha Hermann-Kleiter, Gottfried Baier, Herbert Oberacher, Herbert Tilg, Alexander R Moschen
OBJECTIVE: Nicotinamide phosphoribosyltransferase (NAMPT, also referred to as pre-B cell colony-enhancing factor or visfatin) is critically required for the maintenance of cellular nicotinamide adenine dinucleotide (NAD) supply catalysing the rate-limiting step of the NAD salvage pathway. NAMPT is strongly upregulated in inflammation including IBD and counteracts an increased cellular NAD turnover mediated by NAD-depleting enzymes. These constitute an important mechanistic link between inflammatory, metabolic and transcriptional pathways and NAD metabolism...
September 6, 2017: Gut
https://www.readbyqxmd.com/read/28875492/innate-and-adaptive-immune-cell-metabolism-in-tumor-microenvironment
#13
Duojiao Wu
During an immune response, leukocytes undergo major changes in growth and function that are tightly coupled to dynamic shifts in metabolic processes. Immunometabolism is an emerging field that investigates the interplay between immunological and metabolic processes. The immune system has a key role to play in controlling cancer initiation and progression. Increasing evidence indicates the immunosuppressive nature of the local environment in tumor. In tumor microenvironment, immune cells collectively adapt in a dynamic manner to the metabolic needs of cancer cells, thus prompting tumorigenesis and resistance to treatments...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28867535/innate-lymphoid-cell-immunometabolism
#14
REVIEW
Timothy E O'Sullivan, Joseph C Sun
Innate lymphoid cells (ILCs) are tissue-resident "first responders" of the immune system that function to protect epithelial barriers against pathogens and maintain tissue homeostasis. However, because ILCs are finely tuned to perturbations within tissue microenvironments, they can also contribute to host pathology when upstream activating signals are dysregulated. Recent work has demonstrated that the crosstalk between ILCs and their environment has a significant impact on host metabolism in health and disease...
September 1, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/28855511/blood-monocyte-transcriptome-and-epigenome-analyses-reveal-loci-associated-with-human-atherosclerosis
#15
Yongmei Liu, Lindsay M Reynolds, Jingzhong Ding, Li Hou, Kurt Lohman, Tracey Young, Wei Cui, Zhiqing Huang, Carole Grenier, Ma Wan, Hendrik G Stunnenberg, David Siscovick, Lifang Hou, Bruce M Psaty, Stephen S Rich, Jerome I Rotter, Joel D Kaufman, Gregory L Burke, Susan Murphy, David R Jacobs, Wendy Post, Ina Hoeschele, Douglas A Bell, David Herrington, John S Parks, Russell P Tracy, Charles E McCall, James H Stein
Little is known regarding the epigenetic basis of atherosclerosis. Here we present the CD14+ blood monocyte transcriptome and epigenome signatures associated with human atherosclerosis. The transcriptome signature includes transcription coactivator, ARID5B, which is known to form a chromatin derepressor complex with a histone H3K9Me2-specific demethylase and promote adipogenesis and smooth muscle development. ARID5B CpG (cg25953130) methylation is inversely associated with both ARID5B expression and atherosclerosis, consistent with this CpG residing in an ARID5B enhancer region, based on chromatin capture and histone marks data...
August 30, 2017: Nature Communications
https://www.readbyqxmd.com/read/28854263/assessment-of-metabolic-and-mitochondrial-dynamics-in-cd4-and-cd8-t-cells-in-virologically-suppressed-hiv-positive-individuals-on-combination-antiretroviral-therapy
#16
Jesse J R Masson, Andrew J Murphy, Man K S Lee, Matias Ostrowski, Suzanne M Crowe, Clovis S Palmer
Metabolism plays a fundamental role in supporting the growth, proliferation and effector functions of T cells. We investigated the impact of HIV infection on key processes that regulate glucose uptake and mitochondrial biogenesis in subpopulations of CD4+ and CD8+ T cells from 18 virologically-suppressed HIV-positive individuals on combination antiretroviral therapy (cART; median CD4+ cell count: 728 cells/μl) and 13 HIV seronegative controls. Mitochondrial membrane potential (MMP) and reactive oxygen species (ROS) production were also analysed in total CD4+ and CD8+ T cells...
2017: PloS One
https://www.readbyqxmd.com/read/28847030/macrophages-in-nonalcoholic-fatty-liver-disease-a-role-model-of-pathogenic-immunometabolism
#17
Oliver Krenkel, Frank Tacke
No abstract text is available yet for this article.
August 2017: Seminars in Liver Disease
https://www.readbyqxmd.com/read/28836007/-immunometabolism-and-inflammation-the-cell-is-what-it-eats
#18
N Raulien
No abstract text is available yet for this article.
August 23, 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/28830411/impact-of-moringa-oleifera-lam-leaf-powder-supplementation-versus-nutritional-counseling-on-the-body-mass-index-and-immune-response-of-hiv-patients-on-antiretroviral-therapy-a-single-blind-randomized-control-trial
#19
RANDOMIZED CONTROLLED TRIAL
Koy Tshingani, Philippe Donnen, Henri Mukumbi, Pierre Duez, Michèle Dramaix-Wilmet
BACKGROUND: To achieve effective antiretroviral therapy (ART) outcomes, adherence to an antiretroviral regimen and a good immunometabolic response are essential. Food insecurity can act as a real barrier to adherence to both of these factors. Many people living with human immunodeficiency virus (PLHIV) treated with ART in the Democratic Republic of the Congo (DRC) are faced with nutritional challenges. A significant proportion are affected by under nutrition, which frequently leads to therapeutic failure...
August 22, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28812211/the-immune-system-in-obesity-developing-paradigms-amidst-inconvenient-truths
#20
REVIEW
Madhur Agrawal, Philip A Kern, Barbara S Nikolajczyk
PURPOSE OF REVIEW: Adipose tissue (AT) houses both innate and adaptive immune systems that are crucial for preserving AT function and metabolic homeostasis. In this review, we summarize recent information regarding progression of obesity-associated AT inflammation and insulin resistance. We additionally consider alterations in AT distribution and the immune system in males vs. females and among different racial populations. RECENT FINDINGS: Innate and adaptive immune cell-derived inflammation drives insulin resistance both locally and systemically...
August 15, 2017: Current Diabetes Reports
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