keyword
MENU ▼
Read by QxMD icon Read
search

Immunometabolism

keyword
https://www.readbyqxmd.com/read/27903298/meal-rich-in-carbohydrate-but-not-protein-or-fat-reveals-adverse-immunometabolic-responses-associated-with-obesity
#1
Ehsan Parvaresh Rizi, Sonia Baig, Muhammad Shabeer, Yvonne Teo, Shao Feng Mok, Tze Ping Loh, Faidon Magkos, Sam Virtue, Antonio Vidal-Puig, E Shyong Tai, Chin Meng Khoo, Sue-Anne Toh
BACKGROUND: Obesity-related insulin resistance is linked to inflammation. Immunometabolic function differs between lean and obese subjects, but whether macronutrient composition of ingested meals affects these responses is not well known. We examined the effects of a single meal rich in fat, protein, or carbohydrate on immunometabolic responses. METHODS: Nine lean insulin sensitive (LIS) men and 9 obese insulin resistant (OIR) men ingested high-carbohydrate (HC), high-fat (HF) or high-protein (HP) mixed meals in random order...
December 1, 2016: Nutrition Journal
https://www.readbyqxmd.com/read/27884543/immunometabolism-is-it-under-the-eye-of-the-clock
#2
REVIEW
James O Early, Anne M Curtis
Molecular clocks allow an organism to track time of day, providing the means to anticipate and respond to the daily changes within the environment. In mammals the molecular clock consists of a network of proteins that form auto-regulatory feedback loops that drive rhythms in physiology and behavior. In recent times the extent to which the molecular clock controls key metabolic and immune pathways has begun to emerge. For example, the main clock protein BMAL1 has been linked to mitochondrial metabolism, mitochondrial dynamics and various host defense pathways...
November 21, 2016: Seminars in Immunology
https://www.readbyqxmd.com/read/27866838/glutaminolysis-and-fumarate-accumulation-integrate-immunometabolic-and-epigenetic-programs-in-trained-immunity
#3
Rob J W Arts, Boris Novakovic, Rob Ter Horst, Agostinho Carvalho, Siroon Bekkering, Ekta Lachmandas, Fernando Rodrigues, Ricardo Silvestre, Shih-Chin Cheng, Shuang-Yin Wang, Ehsan Habibi, Luís G Gonçalves, Inês Mesquita, Cristina Cunha, Arjan van Laarhoven, Frank L van de Veerdonk, David L Williams, Jos W M van der Meer, Colin Logie, Luke A O'Neill, Charles A Dinarello, Niels P Riksen, Reinout van Crevel, Clary Clish, Richard A Notebaart, Leo A B Joosten, Hendrik G Stunnenberg, Ramnik J Xavier, Mihai G Netea
Induction of trained immunity (innate immune memory) is mediated by activation of immune and metabolic pathways that result in epigenetic rewiring of cellular functional programs. Through network-level integration of transcriptomics and metabolomics data, we identify glycolysis, glutaminolysis, and the cholesterol synthesis pathway as indispensable for the induction of trained immunity by β-glucan in monocytes. Accumulation of fumarate, due to glutamine replenishment of the TCA cycle, integrates immune and metabolic circuits to induce monocyte epigenetic reprogramming by inhibiting KDM5 histone demethylases...
November 16, 2016: Cell Metabolism
https://www.readbyqxmd.com/read/27858139/lactobacillus-plantarum-hac01-regulates-gut-microbiota-and-adipose-tissue-accumulation-in-a-diet-induced-obesity-murine-model
#4
Soyoung Park, Yosep Ji, Hoe-Yune Jung, Hyunjoon Park, Jihee Kang, Sang-Haeng Choi, Heuynkil Shin, Chang-Kee Hyun, Kyong-Tai Kim, Wilhelm H Holzapfel
The functional features of Lactobacillus plantarum HAC01 (HAC01), isolated from fermented Korean kimchi, were studied with regard to the fat mass, immunometabolic biomarkers and dysbiosis in a diet-induced obesity (DIO) murine model. L. rhamnosus GG (LGG) served as reference strain and a PBS-treated group as control. The administration of L. plantarum HAC01 resulted in reduction of the mesenteric adipose depot, the conjunctive tissue closely associated with the gastrointestinal tract, where lipid oxidative gene expression was upregulated compared to the control group...
November 17, 2016: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27849433/differential-regulation-of-macrophage-glucose-metabolism-by-macrophage-colony-stimulating-factor-and-granulocyte-macrophage-colony-stimulating-factor-implications-for-18-f-fdg-pet-imaging-of-vessel-wall-inflammation
#5
Sina Tavakoli, John D Short, Kevin Downs, Huynh Nga Nguyen, Yanlai Lai, Wei Zhang, Paul Jerabek, Beth Goins, Mehran M Sadeghi, Reto Asmis
Purpose To determine the divergence of immunometabolic phenotypes of macrophages stimulated with macrophage colony-stimulating factor (M-CSF) and granulocyte-M-CSF (GM-CSF) and its implications for fluorine 18 ((18)F) fluorodeoxyglucose (FDG) imaging of atherosclerosis. Materials and Methods This study was approved by the animal care committee. Uptake of 2-deoxyglucose and various indexes of oxidative and glycolytic metabolism were evaluated in nonactivated murine peritoneal macrophages (MΦ0) and macrophages stimulated with M-CSF (MΦM-CSF) or GM-CSF (MΦGM-CSF)...
November 16, 2016: Radiology
https://www.readbyqxmd.com/read/27826245/immunometabolic-responses-after-short-and-moderate-rest-intervals-to-strength-exercise-with-and-without-similar-total-volume
#6
Ricardo R Agostinete, Fabrício E Rossi, Alan José B Magalhaes, Ana Paula R Rocha, Sérgio S Parmezzani, Jose Gerosa-Neto, Jason M Cholewa, Fabio S Lira
This study investigated the influence of short and moderate intervals of recovery with and without equated volume during an acute bout exhaustive strength exercise on metabolic, hormonal and inflammatory responses in healthy adults. Eight physically active men (23.5 ± 3.1) performed three randomized sequences: Short (70% of 1 RM with 30 s of rest); Moderate (70% of 1 RM with 90 s of rest); and Volume-Equated Short (70% of 1 RM with 30 s of rest between sets with a repetition volume equal to that performed in Moderate)...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27825556/metabolic-pathways-in-t-cell-activation-and-lineage-differentiation
#7
REVIEW
Luís Almeida, Matthias Lochner, Luciana Berod, Tim Sparwasser
Recent advances in the field of immunometabolism support the concept that fundamental processes in T cell biology, such as TCR-mediated activation and T helper lineage differentiation, are closely linked to changes in the cellular metabolic programs. Although the major task of the intermediate metabolism is to provide the cell with a constant supply of energy and molecular precursors for the production of biomolecules, the dynamic regulation of metabolic pathways also plays an active role in shaping T cell responses...
November 4, 2016: Seminars in Immunology
https://www.readbyqxmd.com/read/27824629/reply-to-immunometabolism-may-provide-insights-into-novel-mechanisms-of-hiv-reservoir-persistence
#8
Brigitte Autran, Manuela Pogliaghi, Christine Katlama
No abstract text is available yet for this article.
November 28, 2016: AIDS
https://www.readbyqxmd.com/read/27824628/immunometabolism-may-provide-new-insights-into-novel-mechanisms-of-hiv-reservoir-persistence
#9
Clovis S Palmer, Suzanne M Crowe
No abstract text is available yet for this article.
November 28, 2016: AIDS
https://www.readbyqxmd.com/read/27789087/adipose-tissue-at-the-nexus-of-systemic-and-cellular-immunometabolism
#10
REVIEW
Ayano C Kohlgruber, Nelson M LaMarche, Lydia Lynch
At the simplest interpretation of the word, Immunometabolism describes the intersection of the fields of immunology and metabolism. With rapidly growing interest in this field, the term has expanded, and now encompasses a variety of concepts and definitions shaped by an individual's scientific area of expertise, cell-type and tissue of interest, and biological approach. One scientist may be interested in investigating the intrinsic metabolic checkpoints that drive a M1 versus M2 macrophage response, while another may be interested in how macrophages affect systemic metabolism during obesity...
October 24, 2016: Seminars in Immunology
https://www.readbyqxmd.com/read/27779186/pkm2-dependent-glycolysis-promotes-nlrp3-and-aim2-inflammasome-activation
#11
Min Xie, Yan Yu, Rui Kang, Shan Zhu, Liangchun Yang, Ling Zeng, Xiaofang Sun, Minghua Yang, Timothy R Billiar, Haichao Wang, Lizhi Cao, Jianxin Jiang, Daolin Tang
Sepsis, severe sepsis and septic shock are the main cause of mortality in non-cardiac intensive care units. Immunometabolism has been linked to sepsis; however, the precise mechanism by which metabolic reprogramming regulates the inflammatory response is unclear. Here we show that aerobic glycolysis contributes to sepsis by modulating inflammasome activation in macrophages. PKM2-mediated glycolysis promotes inflammasome activation by modulating EIF2AK2 phosphorylation in macrophages. Pharmacological and genetic inhibition of PKM2 or EIF2AK2 attenuates NLRP3 and AIM2 inflammasomes activation, and consequently suppresses the release of IL-1β, IL-18 and HMGB1 by macrophages...
October 25, 2016: Nature Communications
https://www.readbyqxmd.com/read/27771140/integrating-immunometabolism-and-macrophage-diversity
#12
Maxim N Artyomov, Alexey Sergushichev, Joel D Schilling
Macrophages are heterogeneous cells that play a key role in inflammatory and tissue reparative responses. Over the past decade it has become clear that shifts in cellular metabolism are important determinants of macrophage function and phenotype. At the same time, our appreciation of macrophage diversity in vivo has also been increasing. Factors such as cell origin and tissue localization are now recognized as important variables that influence macrophage biology. Whether different macrophage populations also have unique metabolic phenotypes has not been extensively explored...
October 19, 2016: Seminars in Immunology
https://www.readbyqxmd.com/read/27713965/dietary-resistant-starch-type-4-derived-butyrate-attenuates-nuclear-factor-kappa-b1-through-modulation-of-histone-h3-trimethylation-at-lysine-27
#13
Yi Liu, Bijaya Upadhyaya, Ali Reza Fardin-Kia, Robert M Juenemann, Moul Dey
Indigestible resistant starches (RS) are substrates for gut-microbial metabolism and have been shown to attenuate intestinal inflammation but the supporting evidence is inconsistent and lacks mechanistic explanation. We have recently reported dietary RS type 4 (RS4) induced improvements in immunometabolic functions in humans and a concomitant increase in butyrogenic gut-bacteria. Since inflammation is a key component in metabolic diseases, here we investigated the effects of RS4-derived butyrate on the epigenetic repression of pro-inflammatory genes in vivo and in vitro...
September 14, 2016: Food & Function
https://www.readbyqxmd.com/read/27693378/tissue-immunometabolism-development-physiology-and-pathobiology
#14
Kevin Man, Vassily I Kutyavin, Ajay Chawla
Evolution of metazoans resulted in the specialization of cellular and tissue function. This was accomplished by division of labor, which allowed tissue parenchymal cells to prioritize their core functions while ancillary functions were delegated to tissue accessory cells, such as immune, stromal, and endothelial cells. In metabolic organs, the accessory cells communicate with their clients, the tissue parenchymal cells, to optimize cellular processes, allowing organisms to adapt to changes in their environment...
September 21, 2016: Cell Metabolism
https://www.readbyqxmd.com/read/27686054/immunometabolic-circuits-in-trained-immunity
#15
Rob J W Arts, Leo A B Joosten, Mihai G Netea
The classical view that only adaptive immunity can build immunological memory has recently been challenged. Both in organisms lacking adaptive immunity as well as in mammals, the innate immune system can adapt to mount an increased resistance to reinfection, a de facto innate immune memory termed trained immunity. Recent studies have revealed that rewiring of cellular metabolism induced by different immunological signals is a crucial step for determining the epigenetic changes underlying trained immunity. Processes such as a shift of glucose metabolism from oxidative phosphorylation to aerobic glycolysis, increased glutamine metabolism and cholesterol synthesis, play a crucial role in these processes...
September 26, 2016: Seminars in Immunology
https://www.readbyqxmd.com/read/27683748/adipose-tissue-dendritic-cells-are-independent-contributors-to-obesity-induced-inflammation-and-insulin-resistance
#16
Kae Won Cho, Brian F Zamarron, Lindsey A Muir, Kanakadurga Singer, Cara E Porsche, Jennifer B DelProposto, Lynn Geletka, Kevin A Meyer, Robert W O'Rourke, Carey N Lumeng
Dynamic changes of adipose tissue leukocytes, including adipose tissue macrophage (ATM) and adipose tissue dendritic cells (ATDCs), contribute to obesity-induced inflammation and metabolic disease. However, clear discrimination between ATDC and ATM in adipose tissue has limited progress in the field of immunometabolism. In this study, we use CD64 to distinguish ATM and ATDC, and investigated the temporal and functional changes in these myeloid populations during obesity. Flow cytometry and immunostaining demonstrated that the definition of ATM as F4/80(+)CD11b(+) cells overlaps with other leukocytes and that CD45(+)CD64(+) is specific for ATM...
September 28, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27670368/immunometabolism-feast-or-famine-to-combat-infection
#17
Elisabeth Kugelberg
No abstract text is available yet for this article.
September 27, 2016: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/27664755/t-cell-immunometabolism-against-cancer
#18
Shuai Jiang, Wei Yan
T cells play critical roles in host defenses against cancer. External signals prompt activation of naïve T cells, triggering modulation of their immune functions. Emerging evidence reveals that distinct metabolic changes impact the immune functions of naïve and effector T cells, including CD4(+) and CD8(+) T cells. Since T cells appear to be key players in tumor progression, it is important to elucidate whether and how T-cell metabolic reprogramming might alter their impact on cancer progression. Here we briefly review the available knowledge regarding T cells in relation to cancer, focusing on the metabolic reprogramming of T cells and how this influences tumor progression...
September 21, 2016: Cancer Letters
https://www.readbyqxmd.com/read/27626199/food-fight-role-of-itaconate-and-other-metabolites-in-antimicrobial-defense
#19
REVIEW
Harding H Luan, Ruslan Medzhitov
Itaconate is a newly discovered mammalian metabolite bearing significant implications for our understanding of cellular immunometabolism and antimicrobial defense. Here, we explore recent findings regarding the role of itaconate in the innate immune response and highlight the emerging principle that metabolites can have distinct immunological functions independent of bioenergetics.
September 13, 2016: Cell Metabolism
https://www.readbyqxmd.com/read/27592438/rumen-protected-methionine-compared-with-rumen-protected-choline-improves-immunometabolic-status-in-dairy-cows-during-the-peripartal-period
#20
Z Zhou, O Bulgari, M Vailati-Riboni, E Trevisi, M A Ballou, F C Cardoso, D N Luchini, J J Loor
The immunometabolic status of peripartal cows is altered due to changes in liver function, inflammation, and oxidative stress. Nutritional management during this physiological state can affect the biological components of immunometabolism. The objectives of this study were to measure concentrations of biomarkers in plasma, liver tissue, and milk, and also polymorphonuclear leukocyte function to assess the immunometabolic status of cows supplemented with rumen-protected methionine (MET) or choline (CHOL). Forty-eight multiparous Holstein cows were used in a randomized complete block design with 2 × 2 factorial arrangement of MET (Smartamine M, Adisseo NA) and CHOL (ReaShure, Balchem Inc...
August 31, 2016: Journal of Dairy Science
keyword
keyword
6316
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"