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Immunometabolism

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https://www.readbyqxmd.com/read/29670917/pancreatic-beta-cell-death-novel-potential-mechanisms-in-diabetes-therapy
#1
REVIEW
Joselyn Rojas, Valmore Bermudez, Jim Palmar, María Sofía Martínez, Luis Carlos Olivar, Manuel Nava, Daniel Tomey, Milagros Rojas, Juan Salazar, Carlos Garicano, Manuel Velasco
Purpose of Review: Describing the diverse molecular mechanisms (particularly immunological) involved in the death of the pancreatic beta cell in type 1 and type 2 diabetes mellitus. Recent Findings: Beta cell death is the final event in a series of mechanisms that, up to date, have not been entirely clarified; it represents the pathophysiological mechanism in the natural history of diabetes mellitus. These mechanisms are not limited to an apoptotic process only, which is characteristic of the immune-mediated insulitis in type 1 diabetes mellitus...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29658511/immunometabolism-old-drug-new-trick
#2
Yvonne Bordon
No abstract text is available yet for this article.
April 16, 2018: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29629713/immunometabolism-itaconate-helps-keap1-s-cool
#3
Grant Otto
No abstract text is available yet for this article.
April 9, 2018: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29625385/targeting-macrophage-immunometabolism-dawn-in-the-darkness-of-sepsis
#4
REVIEW
V Kumar
Sepsis is known since the time (470 BC) of great Greek physician, Hippocrates. Advancement in modern medicine and establishment of separate branches of medical science dealing with sepsis research have improved its outcome. However, mortality associated with sepsis still remains higher (25-30%) that further increases to 40-50% in the presence of septic shock. For example, sepsis-associated deaths account more in comparison to deaths-associated with myocardial-infarction and certain cancers (i.e. breast and colorectal cancer)...
May 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29619756/tissue-specific-phenotype-and-activation-of-inkt-cells-in-morbidly-obese-subjects-interaction-with-adipocytes-and-effect-of-bariatric-surgery
#5
Soledad López, Sara García-Serrano, Carolina Gutierrez-Repiso, Francisca Rodríguez-Pacheco, Ailec Ho-Plagaro, Concepción Santiago-Fernandez, Gonzalo Alba, Marta Cejudo-Guillen, Alberto Rodríguez-Cañete, Sergio Valdes, Lourdes Garrido-Sanchez, David Pozo, Eduardo García-Fuentes
BACKGROUND: The immune response of visceral adipose tissue (VAT) in obesity, in particular the role of invariant natural killer T (iNKT) cells, has not yet been fully elucidated. OBJECTIVE: To characterize iNKT cells and its activation status in VAT and peripheral blood mononuclear cells (PBMC) in morbidly obese subjects (MO), and to analyze their association with metabolic parameters. SUBJECTS AND METHODS: Twenty non-obese and 20 MO subjects underwent Roux-en-Y gastric bypass (RYGB) and were studied before and 6 months after RYGB...
April 4, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29618839/metformin-adapts-its-cellular-effects-to-bioenergetic-status-in-a-model-of-metabolic-dysfunction
#6
Christopher Auger, Thibacg Sivayoganathan, Abdikarim Abdullahi, Alexandra Parousis, Bo Wen Pang, Marc G Jeschke
Thermal injury induces a complex immunometabolic response, characterized by hyperglycemia, extensive inflammation and persistent hypermetabolism. It has been suggested that attenuation of the hypermetabolic response is beneficial for patient wellbeing. To that effect, metformin represents an attractive therapeutic agent, as its effects on glycemia, inflammation and bioenergetics can improve outcomes in burn patients. Therefore, we studied metformin and its effects on mitochondrial bioenergetics in a murine model of thermal injury...
April 4, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29603622/metabolic-reprogramming-of-host-cells-upon-bacterial-infection-why-shift-to-a-warburg-like-metabolism
#7
REVIEW
Pedro Escoll, Carmen Buchrieser
The finding that the Warburg effect observed in proliferating cancer cells is also observed during immune responses renewed the interest in the study of metabolic reprogramming of immune cells, a field of investigation called immunometabolism. However, the specific mechanisms and processes underlying metabolic changes of host cells upon bacterial infection remain poorly understood. Several recent reports have reported that mammalian cells infected with intracellular bacteria have an altered metabolism that resembles the Warburg effect seen in cancer cells...
March 30, 2018: FEBS Journal
https://www.readbyqxmd.com/read/29593712/mitochondrial-sirtuin-4-resolves-immune-tolerance-in-monocytes-by-rebalancing-glycolysis-and-glucose-oxidation-homeostasis
#8
Jie Tao, Jingpu Zhang, Yun Ling, Charles E McCall, Tie Fu Liu
The goal of this investigation was to define the molecular mechanism underlying physiologic conversion of immune tolerance to resolution of the acute inflammatory response, which is unknown. An example of this knowledge gap and its clinical importance is the broad-based energy deficit and immunometabolic paralysis in blood monocytes from non-survivors of human and mouse sepsis that precludes sepsis resolution. This immunometabolic dysregulation is biomarked by ex vivo endotoxin tolerance to increased glycolysis and TNF-α expression...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29590721/chemerin-blood-levels-are-associated-with-mri-measured-volumes-of-abdominal-adipose-tissue-compartments-and-lifestyle-choices
#9
Tamer Salha, David Andrijević, Zvonimir Vrselja, Vatroslav Šerić, Radivoje Radić, Goran Curic
Obesity is a low-grade chronic inflammatory state, in which a cytokine chemerin with its immunometabolic modulation has an important role. We aimed to study in a healthy population relationships between serum chemerin levels, lifestyle choices and magnetic resonance imaging (MRI) assessed volumes of abdominal visceral (VAT) and subcutaneous (SAT) adipose tissues, which have different cytokine expression profiles. Overall, 73 healthy participants undertook lifestyle questionnaire and underwent anthropometric measurements along with MRI scanning of abdominal SAT and VAT...
December 2017: Acta Clinica Croatica
https://www.readbyqxmd.com/read/29584621/blocking-fatty-acid-fueled-mros-production-within-macrophages-alleviates-acute-gouty-inflammation
#10
Christopher J Hall, Leslie E Sanderson, Lisa M Lawrence, Bregina Pool, Maarten van der Kroef, Elina Ashimbayeva, Denver Britto, Jacquie L Harper, Graham J Lieschke, Jonathan W Astin, Kathryn E Crosier, Nicola Dalbeth, Philip S Crosier
Gout is the most common inflammatory arthritis affecting men. Acute gouty inflammation is triggered by monosodium urate (MSU) crystal deposition in and around joints that activates macrophages into a proinflammatory state, resulting in neutrophil recruitment. A complete understanding of how MSU crystals activate macrophages in vivo has been difficult because of limitations of live imaging this process in traditional animal models. By live imaging the macrophage and neutrophil response to MSU crystals within an intact host (larval zebrafish), we reveal that macrophage activation requires mitochondrial ROS (mROS) generated through fatty acid oxidation...
March 26, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29576845/immunomodulatory-effects-of-diterpene-quinone-derivatives-from-the-roots-of-horminum-pyrenaicum-in-human-pbmc
#11
K Becker, S Schwaiger, B Waltenberger, D Fuchs, C K Pezzei, H Schennach, H Stuppner, J M Gostner
Several phytochemicals were shown to interfere with redox biology in the human system. Moreover, redox biochemistry is crucially involved in the orchestration of immunological cascades. When screening for immunomodulatory compounds, the two interferon gamma- (IFN- γ -) dependent immunometabolic pathways of tryptophan breakdown via indoleamine 2,3-dioxygenase-1 (IDO-1) and neopterin formation by GTP-cyclohydrolase 1 (GTP-CH-I) represent prominent targets, as IFN- γ -related signaling is strongly sensitive to oxidative triggers...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29568345/il-21-modulates-memory-and-exhaustion-phenotype-of-t-cells-in-a-fatty-acid-oxidation-dependent-manner
#12
Romy Loschinski, Martin Böttcher, Andrej Stoll, Heiko Bruns, Andreas Mackensen, Dimitrios Mougiakakos
T-cell-based therapies represent a promising strategy for cancer treatment. In this context, cytokines are discussed as a bona fide instrument for fine-tuning T- cell biology. One promising candidate is the pleiotropic interleukin-21 (IL-21) with only little being known regarding its direct effects on human T-cells. Thus, we sought out to characterize the impact of IL-21 on T-cell metabolism, fitness, and differentiation. Culturing T-cells in presence of IL-21 elicited a metabolic skewing away from aerobic glycolysis towards fatty acid oxidation (FAO)...
March 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29567326/lysine-deacetylases-and-regulated-glycolysis-in-macrophages
#13
REVIEW
Melanie R Shakespear, Abishek Iyer, Catherine Youting Cheng, Kaustav Das Gupta, Amit Singhal, David P Fairlie, Matthew J Sweet
Regulated cellular metabolism has emerged as a fundamental process controlling macrophage functions, but there is still much to uncover about the precise signaling mechanisms involved. Lysine acetylation regulates the activity, stability, and/or localization of metabolic enzymes, as well as inflammatory responses, in macrophages. Two protein families, the classical zinc-dependent histone deacetylases (HDACs) and the NAD-dependent HDACs (sirtuins, SIRTs), mediate lysine deacetylation. We describe here mechanisms by which classical HDACs and SIRTs directly regulate specific glycolytic enzymes, as well as evidence that links these protein deacetylases to the regulation of glycolysis-related genes...
March 19, 2018: Trends in Immunology
https://www.readbyqxmd.com/read/29535731/nlrx1-modulates-immunometabolic-mechanisms-controlling-the-host-gut-microbiota-interactions-during-inflammatory-bowel-disease
#14
Andrew Leber, Raquel Hontecillas, Nuria Tubau-Juni, Victoria Zoccoli-Rodriguez, Vida Abedi, Josep Bassaganya-Riera
Interactions among the gut microbiome, dysregulated immune responses, and genetic factors contribute to the pathogenesis of inflammatory bowel disease (IBD). Nlrx1 -/- mice have exacerbated disease severity, colonic lesions, and increased inflammatory markers. Global transcriptomic analyses demonstrate enhanced mucosal antimicrobial defense response, chemokine and cytokine expression, and epithelial cell metabolism in colitic Nlrx1 -/- mice compared to wild-type (WT) mice. Cell-specificity studies using cre-lox mice demonstrate that the loss of NLRX1 in intestinal epithelial cells (IEC) recapitulate the increased sensitivity to DSS colitis observed in whole body Nlrx1 -/- mice...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29523440/mitochondria-endoplasmic-reticulum-contact-sites-function-as-immunometabolic-hubs-that-orchestrate-the-rapid-recall-response-of-memory-cd8-t-cells
#15
Glenn R Bantug, Marco Fischer, Jasmin Grählert, Maria L Balmer, Gunhild Unterstab, Leyla Develioglu, Rebekah Steiner, Lianjun Zhang, Ana S H Costa, Patrick M Gubser, Anne-Valérie Burgener, Ursula Sauder, Jordan Löliger, Réka Belle, Sarah Dimeloe, Jonas Lötscher, Annaïse Jauch, Mike Recher, Gideon Hönger, Michael N Hall, Pedro Romero, Christian Frezza, Christoph Hess
Glycolysis is linked to the rapid response of memory CD8+ T cells, but the molecular and subcellular structural elements enabling enhanced glucose metabolism in nascent activated memory CD8+ T cells are unknown. We found that rapid activation of protein kinase B (PKB or AKT) by mammalian target of rapamycin complex 2 (mTORC2) led to inhibition of glycogen synthase kinase 3β (GSK3β) at mitochondria-endoplasmic reticulum (ER) junctions. This enabled recruitment of hexokinase I (HK-I) to the voltage-dependent anion channel (VDAC) on mitochondria...
March 1, 2018: Immunity
https://www.readbyqxmd.com/read/29520272/metabolic-modulation-in-macrophage-effector-function
#16
REVIEW
Ciana Diskin, Eva M Pålsson-McDermott
Traditionally cellular respiration or metabolism has been viewed as catabolic and anabolic pathways generating energy and biosynthetic precursors required for growth and general cellular maintenance. However, growing literature provides evidence of a much broader role for metabolic reactions and processes in controlling immunological effector functions. Much of this research into immunometabolism has focused on macrophages, cells that are central in pro- as well as anti-inflammatory responses-responses that in turn are a direct result of metabolic reprogramming...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29515185/immunometabolism-hyperactive-macrophages-link-heart-and-joint-disease
#17
Sarah Onuora
No abstract text is available yet for this article.
April 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29491030/bone-resorption-supporting-immunometabolism
#18
REVIEW
Gustav van Niekerk, Megan Mitchell, Anna-Mart Engelbrecht
Activation of the immune system is associated with an increase in the breakdown of various peripheral tissues, including bone. Despite the widely appreciated role of inflammatory mediators in promoting bone resorption, the functional value behind this process is not completely understood. Recent advances in the field of immunometabolism have highlighted the metabolic reprogramming that takes place in activated immune cells. It is now believed that the breakdown of peripheral tissue provides metabolic substrates to fuel metabolic anabolism in activated immune cells...
February 2018: Biology Letters
https://www.readbyqxmd.com/read/29479350/parallels-in-immunometabolic-adipose-tissue-dysfunction-with-ageing-and-obesity
#19
REVIEW
William Trim, James E Turner, Dylan Thompson
Ageing, like obesity, is often associated with alterations in metabolic and inflammatory processes resulting in morbidity from diseases characterised by poor metabolic control, insulin insensitivity, and inflammation. Ageing populations also exhibit a decline in immune competence referred to as immunosenescence, which contributes to, or might be driven by chronic, low-grade inflammation termed "inflammageing". In recent years, animal and human studies have started to uncover a role for immune cells within the stromal fraction of adipose tissue in driving the health complications that come with obesity, but relatively little work has been conducted in the context of immunometabolic adipose function in ageing...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29477515/the-effects-of-feeding-mixed-tocopherol-oil-on-whole-blood-respiratory-burst-and-neutrophil-immunometabolic-related-gene-expression-in-lactating-dairy-cows
#20
Y Qu, T H Elsasser, S Kahl, M Garcia, C M Scholte, E E Connor, G F Schroeder, K M Moyes
The 4 major tocopherol isoforms differ in their biochemical reactivity and cellular effects due to basic chemical structural differences. Alpha-tocopherol has been well studied regarding effects on bovine polymorphonuclear leukocyte (PMN) function and its involvement in respiratory burst. However, no studies to date have identified the effects of supplementing a mixed tocopherol oil (Tmix) particularly enriched in non-α tocopherol isoforms (i.e., γ- and δ-isoforms) on fundamental immunometabolic changes in dairy cows...
February 21, 2018: Journal of Dairy Science
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