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Immunometabolism

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https://www.readbyqxmd.com/read/28287105/immunometabolism-and-the-land-of-milk-and-honey
#1
Luke O'Neill
No abstract text is available yet for this article.
March 13, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/28285098/role-of-leptin-as-a-link-between-metabolism-and-the-immune-system
#2
REVIEW
Antonio Pérez-Pérez, Teresa Vilariño-García, Patricia Fernández-Riejos, Jenifer Martín-González, Juan José Segura-Egea, Víctor Sánchez-Margalet
Leptin is an adipocyte-derived hormone not only with an important role in the central control of energy metabolism, but also with many pleiotropic effects in different physiological systems. One of these peripheral functions of leptin is a regulatory role in the interplay between energy metabolism and the immune system, being a cornerstone of the new field of immunometabolism. Leptin receptor is expressed throughout the immune system and the regulatory effects of leptin include cells from both the innate and adaptive immune system...
March 4, 2017: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/28280036/myeloid-derived-cullin-3-promotes-stat3-phosphorylation-by-inhibiting-ogt-expression-and-protects-against-intestinal-inflammation
#3
Xinghui Li, Zhibin Zhang, Lupeng Li, Wei Gong, Audrey J Lazenby, Benjamin J Swanson, Laura E Herring, John M Asara, Jeffrey D Singer, Haitao Wen
Signal transducer and activator of transcription 3 (STAT3) is a key mediator of intestinal inflammation and tumorigenesis. However, the molecular mechanism that modulates STAT3 phosphorylation and activation is not fully understood. Here, we demonstrate that modification of STAT3 with O-linked β-N-acetylglucosamine (O-GlcNAc) on threonine 717 (T717) negatively regulates its phosphorylation and targets gene expression in macrophages. We further found that cullin 3 (CUL3), a cullin family E3 ubiquitin ligase, down-regulates the expression of the O-GlcNAc transferase (OGT) and inhibits STAT3 O-GlcNAcylation...
March 9, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28250464/immunometabolism-il-37-fights-inflammation-induced-fatigue
#4
Sarah Onuora
No abstract text is available yet for this article.
March 2, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28239166/immunometabolism-powering-down-leukaemia
#5
Yvonne Bordon
No abstract text is available yet for this article.
February 27, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/28214225/a-relay-pathway-between-arginine-and-tryptophan-metabolism-confers-immunosuppressive-properties-on-dendritic-cells
#6
Giada Mondanelli, Roberta Bianchi, Maria Teresa Pallotta, Ciriana Orabona, Elisa Albini, Alberta Iacono, Maria Laura Belladonna, Carmine Vacca, Francesca Fallarino, Antonio Macchiarulo, Stefano Ugel, Vincenzo Bronte, Federica Gevi, Lello Zolla, Auke Verhaar, Maikel Peppelenbosch, Emilia Maria Cristina Mazza, Silvio Bicciato, Yasmina Laouar, Laura Santambrogio, Paolo Puccetti, Claudia Volpi, Ursula Grohmann
Arginase 1 (Arg1) and indoleamine 2,3-dioxygenase 1 (IDO1) are immunoregulatory enzymes catalyzing the degradation of l-arginine and l-tryptophan, respectively, resulting in local amino acid deprivation. In addition, unlike Arg1, IDO1 is also endowed with non-enzymatic signaling activity in dendritic cells (DCs). Despite considerable knowledge of their individual biology, no integrated functions of Arg1 and IDO1 have been reported yet. We found that IDO1 phosphorylation and consequent activation of IDO1 signaling in DCs was strictly dependent on prior expression of Arg1 and Arg1-dependent production of polyamines...
February 21, 2017: Immunity
https://www.readbyqxmd.com/read/28181143/the-complex-interplay-among-hepatocytes-and-immune-cells-at-the-crossroad-between-inflammation-and-cholesterol-metabolism-in-hyperglycemia
#7
Maurizio Bifulco, Simona Pisanti, Elena Ciaglia
An intriguing piece of evidence for the inflammatory story of type 2 diabetes has come to the light. A recent study by Okin and colleagues adds new clues to the interplay between cholesterol metabolism and immunity and how it impacts glucose homeostasis in inflammatory conditions. But some questions are a still unsolved conundrum. Here we suggest to better dissect the regulatory mechanism of Mevalonate pathway and to underpin a new causative link between immunometabolic dysregulation and diabetes.
February 8, 2017: Endocrine
https://www.readbyqxmd.com/read/28179656/inflammation-metaflammation-and-immunometabolic-disorders
#8
Gökhan S Hotamisligil
Proper regulation and management of energy, substrate diversity and quantity, as well as macromolecular synthesis and breakdown processes, are fundamental to cellular and organismal survival and are paramount to health. Cellular and multicellular organization are defended by the immune response, a robust and critical system through which self is distinguished from non-self, pathogenic signals are recognized and eliminated, and tissue homeostasis is safeguarded. Many layers of evolutionarily conserved interactions occur between immune response and metabolism...
February 8, 2017: Nature
https://www.readbyqxmd.com/read/28155900/immunometabolism-physiologic-role-of-il-1%C3%AE-in-glucose-homeostasis
#9
David Holmes
No abstract text is available yet for this article.
February 3, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28138038/early-suppression-of-adipocyte-lipid-turnover-induces-immunometabolic-modulation-in-cancer-cachexia-syndrome
#10
Felipe Santos Henriques, Rogério Antônio Laurato Sertié, Felipe Oliveira Franco, Pamela Knobl, Rodrigo Xavier Neves, Sandra Andreotti, Fabio Bessa Lima, Adilson Guilherme, Marilia Seelaender, Miguel Luiz Batista
Cancer cachexia is a multifactorial syndrome characterized by body weight loss, atrophy of adipose tissue (AT) and systemic inflammation. However, there is restrict information regarding the mechanisms of immunometabolic response in AT from cancer cachexia. Male Wistar rats were inoculated with 2 × 10(7) of Walker 256 tumor cells [tumor bearing (TB)]. The mesenteric AT (MeAT) was collected on d 0, 4, 7 (early stage), and 14 (cachexia stage) after tumor cell injection. Surgical biopsies for MeAT were obtained from patients who had gastrointestinal cancer with cachexia...
January 30, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28088407/far-off-and-close-up-dry-matter-intake-modulate-indicators-of-immunometabolic-adaptations-to-lactation-in-subcutaneous-adipose-tissue-of-pasture-based-transition-dairy-cows
#11
M Vailati-Riboni, G Farina, F Batistel, A Heiser, M D Mitchell, M A Crookenden, C G Walker, J K Kay, S Meier, J R Roche, J J Loor
The common practice of increasing dietary energy density during the close-up dry period (last ∼3 wk prepartum) has been recently associated with a higher incidence of metabolic disorders after calving. Despite these reports, over-feeding of metabolizable energy (ME) during the far-off, nonlactating period is a common management policy aimed at achieving optimum calving body condition score (BCS) in pasture-based systems, as cows are generally thinner than total mixed ration cows at the end of lactation. Our hypothesis was that both far-off and close-up overfeeding influence the peripartum adipose tissue changes associated with energy balance and inflammatory state...
March 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28054344/nutritional-effects-on-t-cell-immunometabolism
#12
REVIEW
Sivan Cohen, Keiko Danzaki, Nancie J MacIver
T cells are highly influenced by nutrient uptake from their environment, and changes in overall nutritional status, such as malnutrition or obesity, can result in altered T-cell metabolism and behavior. In states of severe malnutrition or starvation, T-cell survival, proliferation, and inflammatory cytokine production are all decreased, as is T-cell glucose uptake and metabolism. The altered T-cell function and metabolism seen in malnutrition is associated with altered adipokine levels, most particularly decreased leptin...
February 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28044055/immunometabolism-complex-metabolic-responses-to-microbial-stimuli
#13
Elisabeth Kugelberg
No abstract text is available yet for this article.
January 3, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/28018344/adjunct-strategies-for-tuberculosis-vaccines-modulating-key-immune-cell-regulatory-mechanisms-to-potentiate-vaccination
#14
REVIEW
Lakshmi Jayashankar, Richard Hafner
Tuberculosis (TB) remains a global health threat of alarming proportions, resulting in 1.5 million deaths worldwide. The only available licensed vaccine, Bacillus Calmette-Guérin, does not confer lifelong protection against active TB. To date, development of an effective vaccine against TB has proven to be elusive, and devising newer approaches for improved vaccination outcomes is an essential goal. Insights gained over the last several years have revealed multiple mechanisms of immune manipulation by Mycobacterium tuberculosis (Mtb) in infected macrophages and dendritic cells that support disease progression and block development of protective immunity...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/28018292/obesity-an-immunometabolic-perspective
#15
REVIEW
Indrani Ray, Sushil K Mahata, Rajat K De
Obesity, characterized by chronic activation of inflammatory pathways, is a critical factor contributing to insulin resistance (IR) and type 2 diabetes (T2D). Free fatty acids (FFAs) are increased in obesity and are implicated as proximate causes of IR and induction of inflammatory signaling in adipose, liver, muscle, and pancreas. Cells of the innate immune system produce cytokines, and other factors that affect insulin signaling and result in the development of IR. In the lean state, adipose tissue is populated by adipose tissue macrophage of the anti-inflammatory M2 type (ATM2) and natural killer (NK) cells; this maintains the insulin-sensitive phenotype because ATM2 cells secrete IL10...
2016: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/27989860/immunometabolic-dysregulation-is-associated-with-reduced-cortical-thickness-of-the-anterior-cingulate-cortex
#16
Laura S van Velzen, Lianne Schmaal, Yuri Milaneschi, Marie-José van Tol, Nic J A van der Wee, Dick J Veltman, Brenda W J H Penninx
BACKGROUND: Immunometabolic dysregulation (low-grade inflammation and metabolic dysregulation) has been associated with the onset and more severe course of multiple psychiatric disorders, partly due to neuroanatomical changes and impaired neuroplasticity. We examined the effect of multiple markers of immunometabolic dysregulation on hippocampal and amygdala volume and anterior cingulate cortex thickness in a large sample of patients with depression and/or anxiety and healthy subjects (N=283)...
February 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/27975706/immunometabolic-regulation-by-triterpene-enriched-fraction-of-eucalyptus-tereticornis-in-adipose-tissue-cell-line-models
#17
S Acin, S Ceballos, D L Muñoz, A Castaño, F Echeverri, N Balcazar
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27956794/galectin-3-and-il-33-st2-axis-roles-and-interplay-in-diet-induced-steatohepatitis
#18
REVIEW
Nada Pejnovic, Ilija Jeftic, Nemanja Jovicic, Nebojsa Arsenijevic, Miodrag L Lukic
Immune reactivity and chronic low-grade inflammation (metaflammation) play an important role in the pathogenesis of obesity-associated metabolic disorders, including type 2 diabetes and nonalcoholic fatty liver disease (NAFLD), a spectrum of diseases that include liver steatosis, nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis. Increased adiposity and insulin resistance contribute to the progression from hepatic steatosis to NASH and fibrosis through the development of proinflammatory and profibrotic processes in the liver, including increased hepatic infiltration of innate and adaptive immune cells, altered balance of cytokines and chemokines, increased reactive oxygen species generation and hepatocellular death...
November 28, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27951413/immunometabolic-parameters-in-overweight-dogs-during-weight-loss-with-or-without-an-exercise-program
#19
A D Vitger, B M Stallknecht, J E Miles, S L Hansen, A Vegge, C R Bjørnvad
The influence of physical activity on metabolic health in overweight dogs is unknown. This study was conducted to evaluate biomarkers of immunometabolic health in relation to changes in physical activity and adiposity. Client-owned overweight dogs participated in a 12-wk intervention based on caloric restriction combined with a training program (fitness and diet [FD] group, n = 8), or caloric restriction alone (diet-only [DO] group, n = 8). Physical activity was monitored by accelerometry. All dogs were fed the same diet and achieved similar weight loss...
November 11, 2016: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/27926861/immunometabolic-pathways-in-bcg-induced-trained-immunity
#20
Rob J W Arts, Agostinho Carvalho, Claudia La Rocca, Carla Palma, Fernando Rodrigues, Ricardo Silvestre, Johanneke Kleinnijenhuis, Ekta Lachmandas, Luís G Gonçalves, Ana Belinha, Cristina Cunha, Marije Oosting, Leo A B Joosten, Giuseppe Matarese, Reinout van Crevel, Mihai G Netea
The protective effects of the tuberculosis vaccine Bacillus Calmette-Guerin (BCG) on unrelated infections are thought to be mediated by long-term metabolic changes and chromatin remodeling through histone modifications in innate immune cells such as monocytes, a process termed trained immunity. Here, we show that BCG induction of trained immunity in monocytes is accompanied by a strong increase in glycolysis and, to a lesser extent, glutamine metabolism, both in an in-vitro model and after vaccination of mice and humans...
December 6, 2016: Cell Reports
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