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https://www.readbyqxmd.com/read/29043851/antioxidants-in-the-treatment-of-cancer
#1
Kanthi Athreya, Marin F Xavier
Several clinical trials have produced conflicting results regarding the benefit of antioxidants in cancer therapy thus questioning the incorporation of these substances in standard treatment regimens. Vitamins E and C, selenium, carotenoids, lycopene, soy products, and green tea extract are a few substances with antioxidant properties that have been studied in detail. This article reviews the results generated over the last 20 years through in vitro and in vivo studies in various types of cancers and stages of cancer treatment...
October 18, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/29031548/green-tea-protects-against-memory-deficits-related-to-maternal-deprivation
#2
Jefferson Menezes, Ben-Hur Neves, Mauren Souza, Pâmela Billig Mello-Carpes
Maternal deprivation (MD) in early life affects the development of the brain, causing cognitive losses in adulthood. Oxidative imbalance may be one of the factors that trigger these deficits. Therapies with antioxidant components, like green tea from Camellia sinensis (GT) has been used to treat or prevent memory deficits in a variety of conditions related to oxidative stress. Here we demonstrate that memory deficits caused by MD can be prevented by GT antioxidant activity in hippocampus. Pregnant female rats were used...
October 13, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28974447/synergistic-toxicity-of-epigallocatechin-3-gallate-and-diethyldithiocarbamate-a-lethal-encounter-involving-redox-active-copper
#3
Ke Zhang, Ruixia Dong, Kang Sun, Xiaoxiao Wang, Jiajia Wang, Chung S Yang, Jinsong Zhang
Dithiocarbamates (DTC) are widely used in agricultural, industrial and therapeutic domains. There are ample opportunities for human exposure to DTC. Green tea extracts, with epigallocatechin-3-gallate (EGCG) being the most abundant constituent, have been used as dietary supplements for body weight reduction. Our hypothesis is that DTC can act as a copper ionophore to increase hepatic levels of redox-active copper which promotes EGCG auto-oxidation to produce oxidative stress and toxicity. The results of the present study in a mouse model is consistent with this hypothesis, showing that co-administration of EGCG and diethyldithiocarbamate - a metabolite of disulfiram (a drug for alcohol aversion therapy), both at tolerable levels, caused lethality...
September 30, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28961534/hyaluronic-acid-green-tea-catechin-micellar-nanocomplexes-fail-safe-cisplatin-nanomedicine-for-the-treatment-of-ovarian-cancer-without-off-target-toxicity
#4
Ki Hyun Bae, Susi Tan, Atsushi Yamashita, Wei Xia Ang, Shu Jun Gao, Shu Wang, Joo Eun Chung, Motoichi Kurisawa
The green tea catechin, (-)-epigallocatechin-3-O-gallate (EGCG), has gained significant attention as a potent adjuvant to enhance the antitumor efficacy of cisplatin while mitigating its harmful side effects. Herein we report the development of a fail-safe cisplatin nanomedicine constructed with hyaluronic acid-EGCG conjugate for ovarian cancer therapy. A simple mixing of this conjugate and cisplatin induces spontaneous self-assembly of micellar nanocomplexes having a spherical core-shell structure. The surface-exposed hyaluronic acid enables efficient delivery of cisplatin into CD44-overexpressing cancer cells via receptor-mediated endocytosis whereas the internally packed EGCG moieties offer an environment favorable for the encapsulation of cisplatin...
December 2017: Biomaterials
https://www.readbyqxmd.com/read/28843267/screening-for-circulating-tumour-cells-allows-early-detection-of-cancer-and-monitoring-of-treatment-effectiveness-an-observational-study
#5
Karin Ried, Peter Eng, Avni Sali
Background: Circulating-Tumour-Cells (CTC) provide a blood biomarker for early carcinogenesis, cancer progression and treatment effectiveness. An increase in CTCs is associated with cancer progression, a CTC decrease with cancer containment or remission. Several technologies have been developed to identify CTC, including the validated Isolation-by-Size-of-Epithelial-Tumour (ISET, Rarecells) technology, combining blood filtration and microscopy using standard histo-pathological criteria. Methods: This observational study compared CTC count to cancer status and cancer risk, by monitoring treatment effectiveness in cancer patients and by screening for CTC in asymptomatic patients with risk factors, including family history of cancer...
August 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28839265/combinatorial-bioactive-botanicals-re-sensitize-tamoxifen-treatment-in-er-negative-breast-cancer-via-epigenetic-reactivation-of-er%C3%AE-expression
#6
Yuanyuan Li, Syed M Meeran, Trygve O Tollefsbol
Conventional cancer prevention has primarily focused on single chemopreventive compounds that may not be sufficiently efficacious. We sought to investigate potential combinatorial effects of epigenetic bioactive botanicals including epigallocatechin-3-gallate (EGCG) in green tea polyphenols (GTPs) and sulforaphane (SFN) in broccoli sprouts (BSp) on neutralizing epigenetic aberrations in estrogen receptor-α (ERα) leading to enhanced anti-hormone therapeutic efficacy in ERα-negative breast cancer. Our results showed that this combinatorial treatment re-sensitized ERα-dependent cellular inhibitory responses to an estrogen antagonist, tamoxifen (TAM), via at least in part, epigenetic reactivation of ERα expression in ERα-negative breast cancer cells...
August 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28815601/antimicrobial-synergism-and-cytotoxic-properties-of-citrus-limon-l-piper-nigrum-l-and-melaleuca-alternifolia-maiden-and-betche-cheel-essential-oils
#7
Miloš M Nikolić, Katarina K Jovanović, Tatjana Lj Marković, Dejan Lj Marković, Nevenka N Gligorijević, Siniša S Radulović, Marina Kostić, Jasmina M Glamočlija, Marina D Soković
OBJECTIVES: The chemical composition, antimicrobial and synergistic effect, and cytotoxic activity of Citrus limon (lemon), Piper nigrum (green pepper) and Melaleuca alternifoila (tea tree) essential oils (EOs) were investigated. METHODS: Chemical analyses of essential oils were tested by GC-FID and GC-MS spectroscopy. The antimicrobial activity assay was conducted using microdilution method against several oral bacteria and Candida spp. originating from the humans with oral disorders...
August 17, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28762712/common-herbal-dietary-supplement-drug-interactions
#8
REVIEW
Gary N Asher, Amanda H Corbett, Roy L Hawke
Nearly 25% of U.S. adults report concurrently taking a prescription medication with a dietary supplement. Some supplements, such as St. John's wort and goldenseal, are known to cause clinically important drug interactions and should be avoided by most patients receiving any pharmacologic therapy. However, many other supplements are predicted to cause interactions based only on in vitro studies that have not been confirmed or have been refuted in human clinical trials. Some supplements may cause interactions with a few medications but are likely to be safe with other medications (e...
July 15, 2017: American Family Physician
https://www.readbyqxmd.com/read/28755734/epigallocatechin-3-gallate-the-prospective-targeting-of-cancer-stem-cells-and-preventing-metastasis-of-chemically-induced-mammary-cancer-in-rats
#9
Sahar S Abd El-Rahman, Gehan Shehab, Heba Nashaat
BACKGROUND: Cancer stem cells are a subpopulation of tumor cells that are capable of self-renewal, capable of tumor recurrence and metastasis, and in addition are resistant to current cancer therapies. Epigallocatechin-3-gallate is a type of catechin found in green tea that is known for its powerful chemoprotective ability. Hence, this study aimed to investigate the effect of epigallocatechin-3-gallate on 7, 12 dimethylbenzanthracene-induced tumor metastasis, angiogenesis and cancer stem cells...
July 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28693189/epigallocatechin-gallate-inhibits-the-growth-of-mda-mb-231-breast-cancer-cells-via-inactivation-of-the-%C3%AE-catenin-signaling-pathway
#10
On-Yu Hong, Eun-Mi Noh, Hye-Yeon Jang, Young-Rae Lee, Byoung Kil Lee, Sung Hoo Jung, Jong-Suk Kim, Hyun Jo Youn
Epigallocatechin gallate (EGCG), a major constituent of green tea, has potential as a treatment for a variety of diseases, including cancer. EGCG induces apoptosis and inhibits tumorigenesis through multiple signaling pathways in breast cancer cells. β-catenin signaling modulators could be useful in the prevention and therapy of breast cancer. However, the precise anticancer effect of EGCG through the β-catenin signaling pathway in breast cancer is unclear. The present study investigated the association between β-catenin expression and clinicopathological factors of breast cancer patients, and the effect of EGCG on β-catenin expression in breast cancer cells...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28657651/diet-and-cancer-prevention-dietary-compounds-dietary-micrornas-and-dietary-exosomes
#11
Zarrin Banikazemi, Hemat Aghagolzadeh Haji, Mohsen Mohammadi, Gholamreza Taheripak, Elmira Iranifar, Mohsen Poursadeghiyan, Abdullah Moridikia, Bahman Rashidi, Mohsen Taghizadeh, Hamed Mirzaei
Cancer is one of main health public problems worldwide. Several factors are involved in beginning and development of cancer. Genetic and internal/external environmental factors can be as important agents that effect on emerging and development of several cancers. Diet and nutrition may be as one of important factors in prevention or treatment of various cancers. A large number studies indicated that suitable dietary patterns may help to cancer prevention or could inhibit development of tumor in cancer patients...
June 28, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28611670/identification-of-epigallocatechin-3-gallate-as-an-inhibitor-of-phosphoglycerate-mutase-1
#12
Xiaoguang Li, Shuai Tang, Qian-Qian Wang, Elaine L-H Leung, Hongyue Jin, Yongzhuo Huang, Jia Liu, Meiyu Geng, Min Huang, Shengtao Yuan, Xiao-Jun Yao, Jian Ding
Targeting metabolic enzymes is believed to provide new therapeutic opportunities for cancer therapy. Phosphoglycerate mutase 1 (PGAM1) is a glycolytic enzyme that importantly coordinates glycolysis, pentose phosphate pathway (PPP) flux and serine biosynthesis in cancer cells and hence gains increasing interest of inhibitor discovery. Only few PGAM1 inhibitors have been reported and the molecular potency remains very limited. In an effort to discover new PGAM1 inhibitors, we carried out a biochemical assay-based screen that was focused on natural products derived small molecule compounds...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28592119/tea-polyphenol-inhibits-autophagy-to-sensitize-epirubicin-induced-apoptosis-in-human-bladder-cancer-cells
#13
W Gu, Y Lin, X Gou, W He
Resistance to anticancer agents such as Epirubicin (EPI) becomes a great challenge for treating bladder cancer. However, the mechanism by which chemoresistance arised is still elusive. In the present study, we showed evidence that EPI induced cytoprotective autophagy in bladder cancer cell lines T24 and BIU87. In addition, EPI robustly activated JNK-mediated phosphorylation of Bcl-2 and disruption of Bcl-2/Beclin-1 complex. Furthermore, the green tea derivative tea polyphenol (TP) inhibited EPI-induced autophagy and promoted apoptosis induced by EPI in bladder cancer cells...
June 8, 2017: Neoplasma
https://www.readbyqxmd.com/read/28587181/chronic-inflammatory-diseases-and-green-tea-polyphenols
#14
REVIEW
Helieh S Oz
Chronic inflammatory diseases affect millions of people globally and the incidence rate is on the rise. While inflammation contributes to the tissue healing process, chronic inflammation can lead to life-long debilitation and loss of tissue function and organ failure. Chronic inflammatory diseases include hepatic, gastrointestinal and neurodegenerative complications which can lead to malignancy. Despite the millennial advancements in diagnostic and therapeutic modalities, there remains no effective cure for patients who suffer from inflammatory diseases...
June 1, 2017: Nutrients
https://www.readbyqxmd.com/read/28534346/the-use-of-inexpensive-broad-spectrum-lower-toxicity-therapeutics-in-chronic-lymphocytic-leukemia
#15
Goran Marjanovic
The use of new and highly efficient targeted therapies for chronic lymphocytic leukemia (CLL) is costly and out of reach for many health care systems. On the other hand, in recent years, few inexpensive, broad-spectrum low-toxicity therapeutics have proven to be effective both in the preclinical and clinical settings. In early-stage CLL, the use of 2000 mg of epigallocatechin-3-gallate (EGCG) from the green tea extract twice a day was able to reduce the absolute leukocyte count. Supplementation of >2000 IU/day of Vitamin D in early low-risk CLL patients is able to delay disease progression and postpone the moment of initiation of the first treatment...
March 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28515762/biochemical-and-histopathological-effects-of-green-tea-nanoparticles-in-ironized-mouse-model
#16
Hidayat Sulistyo, Dhadhang Wahyu Kurniawan, Lantip Rujito
Transfusion in the treatment of thalassemia gives rise to iron deposits in many organs. Since there are many obstacles in the use of deferoxamin (DFO) as an iron chelating agent, it is important to find another alternative therapy that can act as iron chelation. The study aims to compare the histopathological pictures of the heart and spleen in iron-induced rats after administration of DFO and nanoparticles of green tea extract. The research used experimental research design with a post-test only control group...
April 2017: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28507011/influence-of-diet-in-multiple-sclerosis-a-systematic-review
#17
REVIEW
M José Bagur, M Antonia Murcia, Antonia M Jiménez-Monreal, Josep A Tur, M Mar Bibiloni, Gonzalo L Alonso, Magdalena Martínez-Tomé
Nutrition is considered to be a possible factor in the pathogenesis of the neurological disease multiple sclerosis (MS). Nutrition intervention studies suggest that diet may be considered as a complementary treatment to control the progression of the disease; a systematic review of the literature on the influence of diet on MS was therefore conducted. The literature search was conducted by using Medlars Online International Literature (MEDLINE) via PubMed and Scopus. Forty-seven articles met the inclusion criteria...
May 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/28492194/comparison-of-the-streptococcus-mutans-and-lactobacillus-colony-count-changes-in-saliva-following-chlorhexidine-0-12-mouth-rinse-combination-mouth-rinse-and-green-tea-extract-0-5-mouth-rinse-in-children
#18
Rahul J Hegde, Shamika Kamath
BACKGROUND: Compounds present in green tea have been shown to inhibit the growth and activity of bacteria associated with oral infections. The purpose of this study was to compare the efficacy of chlorhexidine (0.12%) mouth rinse and combination (chlorhexidine and sodium fluoride) mouth rinse to that of green tea extract (0.5%) mouth rinse in reducing the salivary count of Streptococcus mutans and Lactobacillus in children. MATERIALS AND METHODS: The sample for the study consisted of 75 school children aged 8-12 years with four or more (decay component) of decayed, missing, and filled teeth index...
April 2017: Journal of the Indian Society of Pedodontics and Preventive Dentistry
https://www.readbyqxmd.com/read/28468264/improvement-of-antioxidant-defences-and-mood-status-by-oral-gaba-tea-administration-in-a-mouse-model-of-post-stroke-depression
#19
Maria Daglia, Arianna Di Lorenzo, Seyed Fazel Nabavi, Antoni Sureda, Sedigheh Khanjani, Akbar Hajizadeh Moghaddam, Nady Braidy, Seyed Mohammad Nabavi
Green GABA (GGABA) and Oolong GABA (OGABA) teas are relatively new varieties of tea, whose chemical composition and functional properties are largely under-studied, despite their promising health capacities. Post stroke depression (PSD) is a complication of stroke with high clinical relevance, yielding increasing mortality and morbidity rates, and a lower response to common therapies and rehabilitation. METHODS: Two chemically characterized commercial samples of GGABA and OGABA were investigated for effects on mood following oral administration using a mouse model of PSD, through common validated tests including the Despair Swimming Test and Tail Suspension Test...
April 29, 2017: Nutrients
https://www.readbyqxmd.com/read/28352352/combination-therapy-with-catechins-and-caffeine-inhibits-fat-accumulation-in-3t3-l1-cells
#20
Xiaojuan Zhu, Licong Yang, Feng Xu, Lezhen Lin, Guodong Zheng
Catechins and caffeine, which are green tea components, have a slimming effect; however, the combinational effect of fat metabolism in 3T3-L1 cells remains unclear. In the present study, 3T3-L1 cells were treated with catechins and caffeine in combination, and it was found that combination therapy with catechins and caffeine markedly reduced intracellular fat accumulation, mRNA expression levels of peroxisome proliferator-activated receptor-γ and CCAAT/enhancer-binding protein α in the early stage of cell differentiation were significantly reduced, and mRNA expression of fatty acid synthetase(FAS) andglycerol-3-phosphate dehydrogenase protein expression levels of FAS were downregulated...
February 2017: Experimental and Therapeutic Medicine
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