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https://www.readbyqxmd.com/read/29908579/herbal-sun-protection-agents-human-studies
#1
Lana Rabinovich, Viktoryia Kazlouskaya
Topical sunscreens are the mainstay for protection from ultraviolet (UV) radiation. With skin cancer rates on the rise and great interest in reversing or preventing the effects of photoaging, new molecules with potential to defend against UV damage have received a great deal of attention. Specifically, there is a growing interest in herbal substances that offer protection against the damaging effects of UV rays. Herbal substances may work as adsorbents of the UV rays and antioxidants and potentially have few side effects...
May 2018: Clinics in Dermatology
https://www.readbyqxmd.com/read/29879248/a-biologically-based-approach-to-acne-and-rosacea
#2
Penelope J Kallis, Alexandra Price, Jacquelyn R Dosal, Anna J Nichols, Jonette Keri
Complementary and alternative medicine (CAM) therapies are increasing in popularity in the field of dermatology. Natural products and holistic approaches are in high demand among patients and research has begun to support their roles in acne and rosacea pathophysiology. In this article, commonly utilized biologically based complementary and alternative therapies for acne and rosacea are reviewed from an evidence-based perspective. Therapies discussed include vitamin C, nicotinamide, zinc, tea tree oil, green tea, resveratrol, curcumin, feverfew, licorice, chamomile, polypodium leucotomos, and nutrition-based approaches...
June 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29843451/in-vitro-and-in-silico-studies-of-the-molecular-interactions-of-epigallocatechin-3-o-gallate-egcg-with-proteins-that-explain-the-health-benefits-of-green-tea
#3
REVIEW
Koichi Saeki, Sumio Hayakawa, Shogo Nakano, Sohei Ito, Yumiko Oishi, Yasuo Suzuki, Mamoru Isemura
Green tea has been shown to have beneficial effects on many diseases such as cancer, obesity, inflammatory diseases, and neurodegenerative disorders. The major green tea component, epigallocatechin-3- O -gallate (EGCG), has been demonstrated to contribute to these effects through its anti-oxidative and pro-oxidative properties. Furthermore, several lines of evidence have indicated that the binding affinity of EGCG to specific proteins may explain its mechanism of action. This review article aims to reveal how EGCG-protein interactions can explain the mechanism by which green tea/EGCG can exhibit health beneficial effects...
May 28, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29804103/role-of-p38-mapks-in-alzheimer-s-disease-implications-for-amyloid-beta-toxicity-targeted-therapy
#4
Ghazaleh Kheiri, Mahsa Dolatshahi, Farzaneh Rahmani, Nima Rezaei
A myriad of environmental and genetic factors, as well as the physiologic process of aging, contribute to Alzheimer's disease (AD) pathology. Neuroinflammation is and has been a focus of interest, as a common gateway for initiation of many of the underlying pathologies of AD. Amyloid beta (Aβ) toxicity, increasing RAGE expression, tau hyperphosphorylation, induction of apoptosis, and deregulated autophagy are among other mechanisms, partly entangled and being explained by activation of mitogen-activated protein kinase (MAPK) and MAPK signaling...
May 28, 2018: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/29796442/the-favourable-effect-of-catechin-in-electrochemotherapy-in-human-pancreatic-cancer-cells
#5
Olga Michel, Dawid Przystupski, Jolanta Saczko, Anna Szewczyk, Natalia Niedzielska, Joanna Rossowska, Julita Kulbacka
Until recently, green tea polyphenols were considered strong antioxidants. However, the latest reports have revealed that bioflavonoids can play a multiple role in anticancer therapy, including the inhibition of cell proliferation and generation of the oxidative stress in a dose-dependent manner. The presented research was designed to examine the potential of the green tea (±)-catechin as a reinforcement of the electrochemotherapy (ECT) with cisplatin in pancreatic cancer in vitro. The study was performed on two cell lines of the pancreatic ductal adenocarcinoma (PDA) - parental EPP85-181P and multidrug-resistant EPP85-181RNOV...
May 22, 2018: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/29765171/risks-and-protective-factors-for-triple-negative-breast-cancer-with-a-focus-on-micronutrients-and-infections
#6
Dagmar Horakova, Katerina Bouchalova, Karel Cwiertka, Ladislav Stepanek, Jana Vlckova, Helena Kollarova
Triple negative breast cancer (TNBC) is an aggressive form of breast cancer (BC) with a poor prognosis. Second, patients cannot benefit from targeted therapy, except for those with BRCA1/2 mutations, for whom poly (ADP-ribose) polymerase (PARP) inhibition therapy using olaparib has recently been approved. As global priorities continue to be epidemiological analysis of BC risk factors and early diagnosis, this review focuses on the risks and protective factors associated with TNBC. A PubMed keyword search for new knowledge on the risks and protective factors for TNBC was carried out...
May 15, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29704403/green-tea-polyphenols-mitigate-gliadin-mediated-inflammation-and-permeability-in-vitro
#7
Charlene B Van Buiten, Joshua D Lambert, Ryan J Elias
SCOPE: Green tea, a polyphenol-rich beverage, has been reported to mitigate a number of inflammatory and hypersensitivity disorders in laboratory models, and has been shown to moderate pathways related to food allergies in vitro. We sought to determine the impact of decaffeinated green tea extract (GTE) on the digestion of gliadin protein in vitro and the effect of physical interactions with GTE on the ability of gliadin to stimulate celiac disease-related symptoms in vitro. METHODS AND RESULTS: Complexation of GTE and gliadin in vitro was confirmed by monitoring increases in turbidity upon titration of GTE into a gliadin solution...
April 28, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29621948/sinecatechins-10-ointment-for-genital-warts-case-report-of-a-beneficial-reaction-in-an-hiv-positive-woman
#8
Roberta Bilenchi, Marco Campoli, Emanuele Trovato, Elisa Cinotti, Pietro Rubegni, Michele Fimiani
Patients with HIV infection are more likely to develop anogenital warts compared to HIV-negative people and are susceptible to treatment failures and recurrences. We report a case of extensive vulvar warts in an HIV-positive woman successfully treated with sinecatechins ointment. After the failure of a combination of cryotherapy and imiquimod 5% cream, we started therapy with sinecatechins 10% ointment. The patient developed an intense local inflammatory reaction after three weeks that induced the discontinuation of the therapy...
January 1, 2018: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29604359/herpes-simplex-virus-virucidal-activity-of-mst-312-and-epigallocatechin-gallate
#9
Prajakta Pradhan, Marie L Nguyen
Herpes Simplex Virus (HSV) is the cause of cold sores, blindness and encephalitis and often leads to recurrent infections. Use of current anti-viral therapies can be limited when drug resistant HSV mutants arise. Thus, novel drugs for the treatment of HSV are needed. Previous research in our laboratory has determined that the telomerase inhibitor, MST-312, interferes with multiple steps of the HSV life cycle. The structure of MST-312 contains moieties related to a natural compound found in green tea, epigallocatechin gallate (EGCG)...
April 2, 2018: Virus Research
https://www.readbyqxmd.com/read/29575316/toxicological-effects-of-camellia-sinensis-green-tea-a-review
#10
REVIEW
Zeinab Bedrood, Maryam Rameshrad, Hossein Hosseinzadeh
Many scientific articles proved that green tea (GT), Camellia sinensis, has a great potential to manage central nervous system, cardiovascular, and metabolic diseases and treat cancer and inflammatory disorders. However, it is important to consider that "natural" is not always "safe." Some relevant articles reported side effects of GT, detrimental effects on health. The aim of this study is to provide a classified report about the toxicity of GT and its main constituents in acute, subacute, subchronic, and chronic states...
March 25, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29570984/effects-of-the-green-tea-polyphenol-epigallocatechin-3-gallate-on-glioma-a-critical-evaluation-of-the-literature
#11
Chung T Le, William P J Leenders, Remco J Molenaar, Cornelis J F van Noorden
The review discusses the effects of Epigallocatechin-3-gallate Gallate (EGCG) on glioma as a basis for future research on clinical application of EGCG. Epidemiological studies on the effects of green tea or EGCG on the risk of glioma is inconclusive due to the limited number of studies, the inclusion of all tea types in these studies, and the focus on caffeine rather than EGCG. In vivo experiments using EGCG monotherapy are inconclusive. Nevertheless, EGCG induces cell death, prevents cellular proliferation, and limits invasion in multiple glioma cell lines...
April 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29532213/treatment-of-inflammatory-bowel-disease-via-green-tea-polyphenols-possible-application-and-protective-approaches
#12
REVIEW
Sajid Ur Rahman, Yu Li, Yingying Huang, Lei Zhu, Shibin Feng, Jinjie Wu, Xichun Wang
Inflammatory bowel disease (IBD) is a collection of inflammatory conditions of colon and small intestine which affect millions of individuals worldwide and the prevalence amount is on the rise. The organ failure as well as loss of tissue function is because of the inflammatory reaction which is the major contributor of tissue healing leading to lifelong debilitation. To stop the tough consequences of inflammation every patient pursues alternative therapy to relieve symptoms. Green tea polyphenols (GTPs) play significant roles in down regulating signaling pathways because GTPs exert effective antioxidant properties and regulate Toll-like receptor 4 (TLR4) expression via certain receptor, inhibited endotoxin-mediated tumor necrosis factor alpha (TNF-α) production by blocking transcription nuclear factor-kappa B (NF-kB) activation and upstream of mediated I kappa B kinase complex pathway activities, as well as intrusion with the flow of cytokines and synthesis of cyclooxygenase-2 (COX-2)...
April 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29503145/statin-dose-reduction-with-complementary-diet-therapy-a-pilot-study-of-personalized-medicine
#13
Bianca Scolaro, Marina S Nogueira, Aline Paiva, Adriana Bertolami, Lucia P Barroso, Tomas Vaisar, Sean P Heffron, Edward A Fisher, Inar A Castro
OBJECTIVE: Statin intolerance, whether real or perceived, is a growing issue in clinical practice. Our aim was to evaluate the effects of reduced-dose statin therapy complemented with nutraceuticals. METHODS: First phase: Initially, 53 type 2 diabetic statin-treated patients received a supplementation with fish oil (1.7 g EPA + DHA/day), chocolate containing plant sterols (2.2 g/day), and green tea (two sachets/day) for 6 weeks. Second phase: "Good responders" to supplementation were identified after multivariate analysis (n = 10), and recruited for a pilot protocol of statin dose reduction...
May 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29482780/diet-and-supplements-in-cancer-prevention-and-treatment-clinical-evidences-and-future-perspectives
#14
REVIEW
Claudio Vernieri, Federico Nichetti, Alessandra Raimondi, Sara Pusceddu, Marco Platania, Franco Berrino, Filippo de Braud
In recent years, calorie-restricted dietary regimens and compounds such as vitamins, curcumin, green tea extracts and omega-3 fatty acids have attracted attention for their potential anticancer effects. While definitive conclusions cannot be drawn in this field, many patients adopt complementary antitumor therapies aiming to improve efficacy or reduce toxicity of chemotherapy, with uncertain benefits and the risk of additional toxicities or antagonistic interactions with standard therapies. In this manuscript, we review the different levels of available evidence to suggest or discourage specific dietary changes or supplement use in the context of cancer prevention, reduction of tumor recurrences and survival prolongation in advanced cancers...
March 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29473233/highly-augmented-drug-loading-and-stability-of-micellar-nanocomplexes-composed-of-doxorubicin-and-poly-ethylene-glycol-green-tea-catechin-conjugate-for-cancer-therapy
#15
Kun Liang, Joo Eun Chung, Shu Jun Gao, Nunnarpas Yongvongsoontorn, Motoichi Kurisawa
Low drug loading and instability in blood circulation are two key challenges that impede the successful clinical translation of nanomedicine, as they result in only marginal therapeutic efficacy and toxic side effects associated with premature drug leakage, respectively. Herein, highly stable and ultrahigh drug loading micellar nanocomplexes (MNCs) based on the self-assembly of the anticancer drug doxorubicin (DOX) and a poly(ethylene glycol)-epigallocatechin-3-O-gallate (EGCG) conjugate are developed. The formation of these MNCs is facilitated by strong favorable intermolecular interactions between the structurally similar aromatic EGCG and DOX molecules, which impart exceptionally high drug-loading capability of up to 88% and excellent thermodynamic and kinetic stability...
April 2018: Advanced Materials
https://www.readbyqxmd.com/read/29402411/epigallocatechin-3-gallate-attenuates-acute-and-chronic-psoriatic-itch-in-mice-involvement-of-antioxidant-anti-inflammatory-effects-and-suppression-of-erk-and-akt-signaling-pathways
#16
Ran Guo, Feng-Ming Zhou, Cun-Jin Su, Teng-Teng Liu, Yan Zhou, Li Fan, Zhi-Hong Wang, Xu Liu, Ya Huang, Tong Liu, Jianping Yang, Li-Hua Chen
Chronic itch is a distressing symptom of many skin diseases and negatively impacts quality of life. However, there is no medication for most forms of chronic itch, although antihistamines are often used for anti-itch treatment. Epigallocatechin-3-gallate (EGCG), a major green tea polyphenol, exhibits anti-oxidative and anti-inflammatory properties. Our previous studies highlighted a key role of oxidative stress and proinflammatory cytokines in acute and chronic itch. Here, we evaluated the effects of green tea polyphenon 60 and EGCG on acute and chronic itch in mouse models and explored its potential mechanisms...
February 19, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29388183/aspalathin-from-rooibos-aspalathus-linearis-a-bioactive-c-glucosyl-dihydrochalcone-with-potential-to-target-the-metabolic-syndrome
#17
Rabia Johnson, Dalene de Beer, Phiwayinkosi V Dludla, Daneel Ferreira, Christo J F Muller, Elizabeth Joubert
Aspalathin is a C -glucosyl dihydrochalcone that is abundantly present in Aspalathus linearis . This endemic South African plant, belonging to the Cape Floristic region, is normally used for production of rooibos, a herbal tea. Aspalathin was valued initially only as precursor in the formation of the characteristic red-brown colour of "fermented" rooibos, but the hype about the potential role of natural antioxidants to alleviate oxidative stress, shifted interest in aspalathin to its antioxidant properties and subsequently, its potential role to improve metabolic syndrome, a disease condition interrelated with oxidative stress...
January 31, 2018: Planta Medica
https://www.readbyqxmd.com/read/29383023/of-mice-and-men-a-novel-dietary-supplement-for-the-treatment-of-ulcerative-colitis
#18
Shiran Shapira, Ari Leshno, Daniel Katz, Nitsan Maharshak, Gil Hevroni, Maayan Jean-David, Sarah Kraus, Lior Galazan, Ilan Aroch, Dina Kazanov, Aharon Hallack, Stewart Becker, Mark Umanski, Menachem Moshkowitz, Iris Dotan, Nadir Arber
Background: Curcumin, green tea polyphenols and selenium possess anti-inflammatory and anti-oxidant properties. Individually they have demonstrated some efficacy in animal models and human subjects with inflammatory bowel disease (IBD). To evaluate the efficacy and safety of Coltect [Curcumin (500 mg), green tea (250 mg) and selenium (100 µg)] in vivo and in patients with ulcerative colitis (UC). Methods: Each component was compared to placebo in a DSS mice colitis model...
2018: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/29207033/epigallocatechin-3-gallate-inhibits-inflammation-and-epithelial%C3%A2-mesenchymal-transition-through-the-pi3k-akt-pathway-via-upregulation-of-pten-in-asthma
#19
Nan Yang, Han Zhang, Xuxu Cai, Yunxiao Shang
Asthma is a chronic disease associated with hyperresponsiveness, obstruction and remodeling of the airways. Epithelial-mesenchymal transition (EMT) has an important role in these alterations and may account for the accumulation of subepithelial mesenchymal cells, thus contributing to airway hyperresponsiveness and remodeling. Epigallo-catechin‑3‑gallate (EGCG), which is a type of polyphenol, is the most potent ingredient in green tea, and exhibits antibacterial, antiviral, antioxidative, anticancer and chemopreventive activities...
February 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29200719/anti-cancer-effects-of-polyphenolic-compounds-in-epidermal-growth-factor-receptor-tyrosine-kinase-inhibitor-resistant-non-small-cell-lung-cancer
#20
Hyungmin Jeong, Ai N H Phan, Jong-Whan Choi
Background: Polyphenolic phytochemicals are natural compounds, easily found in fruits and vegetables. Importantly, polyphenols have been intensively studied as excellent antioxidant activity which contributes to anticancer function of the natural compounds. Lung cancer has been reported to mainly account for cancer-related deaths in the world. Moreover, epidermal growth factor receptor tyrosine kinase inhibitor (TKI) resistance is one of the biggest issues in cancer treatment, especially in nonsmall cell lung cancer (NSCLC)...
October 2017: Pharmacognosy Magazine
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