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https://www.readbyqxmd.com/read/29131612/functional-characterization-of-epitheaflagallin-3-o-gallate-generated-in-laccase-treated-green-tea-extracts-in-the-presence-of-gallic-acid
#1
Nobuya Itoh, Junji Kurokawa, Yasuhiro Isogai, Masaru Ogasawara, Takayuki Matsunaga, Tutomu Okubo, Yuji Katsube
Epitheaflagallin (ETFG) and epitheaflagallin 3-O-gallate (ETFGg) are minor polyphenols in black tea extract that are enzymatically synthesized from epigallocatechin (EGC) and epigallocatechin gallate (EGCg), respectively, in green tea extract via laccase oxidation in the presence of gallic acid. The constituents of laccase-treated green tea extract in the presence of gallic acid are thus quite different from those of non-laccase-treated green tea extract: EGC and EGCg are present in lower concentrations, and ETFG and ETFGg are present in higher concentrations...
November 13, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29129232/effect-of-green-tea-on-plasma-leptin-and-ghrelin-levels-a%C3%A2-systematic-review-and-meta-analysis-of-randomized-controlled-clinical-trials
#2
Fahimeh Haghighatdoost, B Fatemeh Nobakht M Gh, Mitra Hariri
OBJECTIVE: The purpose of this study was to conduct a meta-analysis of randomized controlled trials (RCTs) to assess the effect of green tea on serum leptin and ghrelin concentrations. METHODS: We searched PubMed, ISI Web of Science, Scopus, and Google scholar databases up to December 2016. The searches included RCTs conducted in human adults, and studies on the effect of green tea and green tea extract on serum leptin and ghrelin concentrations as outcome variables...
January 2018: Nutrition
https://www.readbyqxmd.com/read/29080460/chlorogenic-acid-cga-a-pharmacological-review-and-call-for-further-research
#3
REVIEW
Muhammad Naveed, Veghar Hejazi, Muhammad Abbas, Asghar Ali Kamboh, Ghulam Jilany Khan, Muhammad Shumzaid, Fawwad Ahmad, Daryoush Babazadeh, Xia FangFang, Faezeh Modarresi-Ghazani, Li WenHua, Zhou XiaoHui
Phenolic acids have recently gained substantial attention due to their various practical, biological and pharmacological effects. Chlorogenic Acid (CGA, 3-CQA) is a most abundant isomer among caffeoylquinic acid isomers (3-, 4-, and 5-CQA), that currently known as 5-CQA as per guidelines of IUPAC. It is one of the most available acids among phenolic acid compounds which can be naturally found in green coffee extracts and tea. CGA is an important and biologically active dietary polyphenol, playing several important and therapeutic roles such as antioxidant activity, antibacterial, hepatoprotective, cardioprotective, anti-inflammatory, antipyretic, neuroprotective, anti-obesity, antiviral, anti-microbial, anti-hypertension, free radicals scavenger and a central nervous system (CNS) stimulator...
October 25, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29078075/effect-of-green-tea-on-hepatic-lipid-metabolism-in-mice-fed-a-high-fat-diet
#4
Miso Nam, Myung-Sook Choi, Ji-Young Choi, Nami Kim, Min-Sun Kim, Sunhee Jung, Juyeon Kim, Do Hyun Ryu, Geum-Sook Hwang
Green tea (GT) is a widely consumed beverage with health benefits, including antiobesity effects; however, the efficacy of GT on lipid levels associated with obesity is not clearly understood. Here, we examined the impact of GT consumption on lipid metabolism in the livers of high-fat diet (HFD)-induced obese mice. We performed lipid profiling using ultraperformance liquid chromatography quadrupole time-of-flight mass spectrometry in C57BL/6J mice fed a normal diet (ND), HFD and HFD with GT for 12 weeks. The partial least squares discriminant analysis score plot showed a difference among the groups and revealed that the levels of several lipid metabolites were altered in mice fed HFD with GT...
September 19, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29065471/association-between-diet-quality-and-adiposity-in-the-atlantic-path-cohort
#5
Vanessa DeClercq, Yunsong Cui, Cynthia Forbes, Scott A Grandy, Melanie Keats, Louise Parker, Ellen Sweeney, Zhijie Michael Yu, Trevor J B Dummer
The aim of this study was to examine diet quality among participants in the Atlantic Partnership for Tomorrow's Health (PATH) cohort and to assess the association with adiposity. Data were collected from participants (n = 23,768) aged 35-69 years that were residents of the Atlantic Canadian provinces. Both measured and self-reported data were used to examine adiposity (including body mass index (BMI), abdominal obesity, waist-to-hip ratio and fat mass) and food frequency questionnaires were used to assess diet quality...
October 21, 2017: Nutrients
https://www.readbyqxmd.com/read/29018779/differential-tissue-specific-and-pathway-specific-anti-obesity-effects-of-green-tea-and-taeumjowitang-a-traditional-korean-medicine-in-mice
#6
Junil Kim, Sujin Park, Haein An, Ji-Young Choi, Myung-Sook Choi, Sang-Woon Choi, Seong-Jin Kim
BACKGROUND: Traditional medicines have been leveraged for the treatment and prevention of obesity, one of the fastest growing diseases in the world. However, the exact mechanisms underlying the effects of traditional medicine on obesity are not yet fully understood. METHODS: We produced the transcriptomes of epididymal white adipose tissue (eWAT), liver, muscle, and hypothalamus harvested from mice fed a normal diet, high-fat-diet alone, high-fat-diet together with green tea, or a high-fat-diet together with Taeumjowitang, a traditional Korean medicine...
September 2017: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28965248/decaffeinated-green-and-black-tea-polyphenols-decrease-weight-gain-and-alter-microbiome-populations-and-function-in-diet-induced-obese-mice
#7
Susanne M Henning, Jieping Yang, Mark Hsu, Ru-Po Lee, Emma M Grojean, Austin Ly, Chi-Hong Tseng, David Heber, Zhaoping Li
PURPOSE: Decaffeinated green tea (GT) and black tea (BT) polyphenols inhibit weight gain in mice fed an obesogenic diet. Since the intestinal microflora is an important contributor to obesity, it was the objective of this study to determine whether the intestinal microflora plays a role in the anti-obesogenic effect of GT and BT. METHODS: C57BL/6J mice were fed a high-fat/high-sucrose diet (HF/HS, 32% energy from fat; 25% energy from sucrose) or the same diet supplemented with 0...
September 30, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28895793/food-stabilizing-antioxidants-increase-nutrient-bioavailability-in-the-in-vitro-model
#8
Magdalena Mika, Agnieszka Wikiera, Anna Antończyk, Maja Grabacka
OBJECTIVE: We investigated whether antioxidants may enhance bioavailability of lipids and carbohydrates and therefore increase the risk of obesity development. METHODS: We tested how supplementation with antioxidants (0.01% butylated hydroxytoluene [BHT], α-tocopherol, and green tea catechins) of a diet containing butter and wheat bread affects bioavailability of fats and carbohydrates. The absorption of the in vitro digested diet was estimated in the intestinal epithelia model of the Caco-2 cells cultured in Transwell chambers...
September 12, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28891395/effects-of-catechins-and-caffeine-on-the-development-of-atherosclerosis-in-mice
#9
Litong Liu, Izumi Nagai, Ying Gao, Yoshibumi Matsushima, Yoshichika Kawai, Kazutoshi Sayama
Atherosclerosis is one of the diseases related to metabolic syndrome which is caused by obesity. Previous reports have shown that green tea and its components have anti-obesity effect. We examined whether catechins and caffeine can prevent the development of atherosclerosis by oral administration, singly or in combination to the atherosclerosis model mice. Results demonstrated that the number of atherosclerotic regions in the aorta was significantly reduced by the combined treatment, and the atherosclerotic area was also improved...
October 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28863365/a-polyphenolic-extract-from-green-tea-leaves-activates-fat-browning-in-high-fat-diet-induced-obese-mice
#10
Audrey M Neyrinck, Laure B Bindels, Lucie Geurts, Matthias Van Hul, Patrice D Cani, Nathalie M Delzenne
Fat browning has emerged as an attractive target for the treatment of obesity and related metabolic disorders. Its activation leads to increased energy expenditure and reduced adiposity, thus contributing to a better energy homeostasis. Green tea extracts (GTEs) were shown to attenuate obesity and low-grade inflammation and to induce the lipolytic pathway in the white adipose tissue (WAT) of mice fed a high-fat diet. The aim of the present study was to determine whether the antiobesity effect of an extract from green tea leaves was associated with the activation of browning in the WAT and/or the inhibition of whitening in the brown adipose tissue (BAT) in HF-diet induced obese mice...
November 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28804438/green-tea-extract-induces-genes-related-to-browning-of-white-adipose-tissue-and-limits-weight-gain-in-high-energy-diet-fed-rat
#11
Li-Han Chen, Yi-Wen Chien, Chung-Tiang Liang, Ching-Hung Chan, Meng-Han Fan, Hui-Yu Huang
Background: A wealth of research has reported on the anti-obesity effects of green tea extract (GTE). Although browning of white adipose tissue (WAT) has been reported to attenuate obesity, no study has disclosed the effects of GTE on browning in Sprague Dawley rats. Objectives: The aims of the study were to investigate the effects of GTE on anti-obesity and browning, and their underlying mechanisms. Methods: Four groups of rats (n=10/group) were used including a normal diet with vehicle treatment, and a high-energy diet (HED) with vehicle or GTE by oral gavage at 77...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/28760074/redox-status-on-different-regions-of-the-central-nervous-system-of-obese-and-lean-rats-treated-with-green-tea-extract
#12
Rita Cassia Macedo, Eduardo Fernandes Bondan, Rosemari Otton
OBJECTIVES: The purpose of this study was to evaluate some indicators of redox status, and inflammation on different regions of the central nervous system (CNS) of obese rats treated with green tea (GT). We hypothesized that obesity could affect the redox balance in different brain regions due to the diverse nature of the cells as well as the selective neuronal vulnerability to oxidative stress, and GT could triggers benefits effects restoring the redox status. METHODS: Male Wistar rats were treated with GT by gavage (12 weeks/5 days/week; 500 mg/kg of body weight) and obesity was induced by cafeteria diet (8 weeks)...
July 31, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28739640/egcg-ameliorates-high-fat-and-high-fructose-induced-cognitive-defects-by-regulating-the-irs-akt-and-erk-creb-bdnf
#13
Yashi Mi, Guoyuan Qi, Rong Fan, Qinglian Qiao, Yali Sun, Yuqi Gao, Xuebo Liu
Obesity, which is caused by an energy imbalance between calorie intake and consumption, has become a major international health burden. Obesity increases the risk of insulin resistance and age-related cognitive decline, accompanied by peripheral inflammation. (-)-Epigallocatechin-3-gallate (EGCG), the major polyphenol in green tea, possesses antioxidant, anti-inflammatory, and cardioprotective activities; however, few reports have focused on its potential effect on cognitive disorders. In this study, our goal was to investigate the protective effects of EGCG treatment on insulin resistance and memory impairment induced by a high-fat and high-fructose diet (HFFD)...
July 24, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28678746/long-term-supplementation-of-decaffeinated-green-tea-extract-does-not-modify-body-weight-or-abdominal-obesity-in-a-randomized-trial-of-men-at-high-risk-for-prostate-cancer
#14
Nagi B Kumar, Roshni Patel, Julio Pow-Sang, Philippe E Spiess, Raoul Salup, Christopher R Williams, Michael J Schell
BACKGROUND: Evidence continues to demonstrate the role of obesity in prostate carcinogenesis and prognosis, underscoring the need to identify and continue to evaluate the effective interventions to reduce obesity in populations at high risk. The aim of the study was to determine the effect of daily consumption of decaffeinated green tea catechins (GTC) formulation (Polyphenon E® (PolyE)) for 1 year on biomarkers of obesity in men who are at high risk for prostate cancer. MATERIALS AND METHODS: A randomized, double-blinded trial was conducted targeting 97 men diagnosed with HGPIN or ASAP...
June 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28665330/effects-of-epigallocatechin-3-gallate-on-autophagic-lipolysis-in-adipocytes
#15
Sang-Nam Kim, Hyun-Jung Kwon, Seun Akindehin, Hyun Woo Jeong, Yun-Hee Lee
Previous studies demonstrated effects of green tea on weight loss; however, green tea-induced modulation of adipocyte function is not fully understood. Here, we investigated effects of the major green tea phytochemical, epigallocatechin-3-gallate (EGCG) on triglyceride contents, lipolysis, mitochondrial function, and autophagy, in adipocytes differentiated from C₃H10T1/2 cells and immortalized pre-adipocytes in vitro. EGCG reduced the triglycerol content significantly in adipocytes by 25%, comparable to the nutrient starvation state...
June 30, 2017: Nutrients
https://www.readbyqxmd.com/read/28659734/effects-of-epigallocatechin-3-gallate-on-thermogenesis-and-mitochondrial-biogenesis-in-brown-adipose-tissues-of-diet-induced-obese-mice
#16
Mak-Soon Lee, Yoonjin Shin, Sunyoon Jung, Yangha Kim
Background: Epigallocatechin-3-gallate (EGCG) is the major polyphenol in green tea and has been considered a natural agent that can help to reduce the risk of obesity. Objective: The aim of this study was to investigate the effects of EGCG on thermogenesis and mitochondrial biogenesis in brown adipose tissue (BAT) of diet-induced obese mice. Methods: Male C57BL/6J mice were provided a high-fat diet for 8 weeks to induce obesity, following which they were divided into two groups: one on a high-fat control diet and the other on a 0...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/28643888/combination-of-citrus-polymethoxyflavones-green-tea-polyphenols-and-lychee-extracts-suppresses-obesity-and-hepatic-steatosis-in-high-fat-diet-induced-obese-mice
#17
Min-Hsiung Pan, Guliang Yang, Shiming Li, Ming-Yi Li, Mei-Ling Tsai, Jia-Ching Wu, Vladimir Badmaev, Chi-Tang Ho, Ching-Shu Lai
SCOPE: SlimTrym(®) is a formulated product composed of citrus polymethoxyflavones (PMFs), green tea extract, and lychee extract. We investigated the effect of dietary SlimTrym(®) on diet-induced obesity and associated non-alcoholic fatty liver disease (NAFLD) in mice. METHODS AND RESULTS: Male C57BL/6 mice were fed a normal diet (ND), high fat diet (HFD) or HFD containing 0.1% or 0.5% SlimTrym(®) for 16 weeks. Dietary SlimTrym(®) significantly reduced weight gain and relative perigonadal, retroperitoneal, mesenteric fat weight as well as the size of adipocyte in HFD-fed mice...
June 23, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28638220/green-tea-polyphenols-ameliorate-non-alcoholic-fatty-liver-disease-through-upregulating-ampk-activation-in-high-fat-fed-zucker-fatty-rats
#18
Yi Tan, Jane Kim, Jing Cheng, Madeleine Ong, Wei-Guo Lao, Xing-Liang Jin, Yi-Guang Lin, Linda Xiao, Xue-Qiong Zhu, Xian-Qin Qu
AIM: To investigate protective effects and molecular mechanisms of green tea polyphenols (GTP) on non-alcoholic fatty liver disease (NAFLD) in Zucker fatty (ZF) rats. METHODS: Male ZF rats were fed a high-fat diet (HFD) for 2 wk then treated with GTP (200 mg/kg) or saline (5 mL/kg) for 8 wk, with Zucker lean rat as their control. At the end of experiment, serum and liver tissue were collected for measurement of metabolic parameters, alanine aminotransferase (ALT) and aspartate aminotransferase (AST), inflammatory cytokines and hepatic triglyceride and liver histology...
June 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28636182/effects-of-green-tea-on-lipid-metabolism-in-overweight-or-obese-people-a-meta-analysis-of-randomized-controlled-trials
#19
Yuan Fen, Dong Hui, Fang Ke, Gong Jing, Lu Fu Er
SCOPE: The effects of green tea on lipid metabolism were inconsistent. The objective of this meta-analysis was to evaluate the effects of green tea on lipid metabolism in overweight or obese people. METHODS AND RESULTS: We searched randomized controlled trials(RCTs) comparing green tea with a control on lipid metabolism on PUBMED and WEB OF SCIENCE (January 1990 to September 2016), COCHRANE and EMBASE (updated to October 2016), and the Chinese databases CNKI, WanFang and CBMD...
June 21, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28631923/influence-of-ingesting-a-flavonoid-rich-supplement-on-the-metabolome-and-concentration-of-urine-phenolics-in-overweight-obese-women
#20
David C Nieman, Sivapriya Ramamoorthy, Colin D Kay, Courtney L Goodman, Christopher R Capps, Zack L Shue, Nicole Heyl, Mary H Grace, Mary A Lila
This study evaluated the effect of ingesting a flavonoid-rich supplement (329 mg/d) on total urine phenolics and shifts in plasma metabolites in overweight/obese female adults using untargeted metabolomics procedures. Participants (N = 103, 18-65 y, BMI ≥ 25 kg/m(2)) were randomized to flavonoid (F) or placebo (P) groups for 12 weeks with blood and 24 h urine samples collected prestudy and after 4 and 12 weeks in a parallel design. Supplements were prepared as chewable tablets and included vitamin C, wild bilberry fruit extract, green tea leaf extract, quercetin, caffeine, and omega 3 fatty acids...
June 30, 2017: Journal of Proteome Research
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