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https://www.readbyqxmd.com/read/29734116/polyphenol-rich-green-tea-extract-improves-adipose-tissue-metabolism-by-down-regulating-mir-335-expression-and-mitigating-insulin-resistance-and-inflammation
#1
Rosemari Otton, Anaysa Paola Bolin, Leticia Torres Ferreira, Marcelo Paradiso Marinovic, Andrea Livia Silva Rocha, Marcelo Alves Mori
Obesity leads to changes in miRNA expression in adipose tissue, and this modulation is linked to the pathophysiology of the disease. Green tea (GT) is a natural source of polyphenols that have been shown to confer health benefits, particularly preventing metabolic diseases. Here, we investigated if the beneficial effects of GT in obesity results from changes in the miRNA profile in white adipose tissue. GT treatment [500 mg/body weight (BW)/12 weeks] increased energy expenditure of high-fat diet-fed mice (16 weeks), leading to reduced weight gain, decreased adiposity, reduced inflammation and improved insulin sensitivity...
April 7, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29665620/personalized-cardio-metabolic-responses-to-an-anti-inflammatory-nutrition-intervention-in-obese-adolescents-a-randomized-controlled-crossover-trial
#2
Aoibheann M McMorrow, Ruth M Connaughton, Tiago R Magalhães, Fiona C McGillicuddy, Maria F Hughes, David Cheishvili, Melissa J Morine, Sean Ennis, Marie-Louise Healy, Edna F Roche, Richard E Tremblay, Moshe Szyf, Fiona E Lithander, Helen M Roche
SCOPE: Chronic inflammation and hypoadiponectinemia are characteristic of obesity-induced insulin resistance (IR). The effect of an anti-inflammatory nutrition supplement (AINS) on IR and adiponectin biology in overweight adolescents was investigated. The secondary objective was to examine the extent to which individuals' biomarker profiles, derived from baseline phenotypes, predicted response or not to the AINS. Additionally, the impact of DNA methylation on intervention efficacy was assessed...
April 17, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29659496/synthesis-of-theaflavins-and-their-functions
#3
REVIEW
Masumi Takemoto, Hiroaki Takemoto
Numerous epidemiological and interventional clinical studies have consistently reported that black tea is good for human health. The polyphenolic compound, theaflavin, and its galloyl esters (theaflavins) are the primary red pigments in black tea that possess several health benefits, including fat-reducing and glucose-lowering capabilities and lifestyle-related disease prevention related to anti-obesity, anticancer, anti-atherosclerotic, anti-inflammatory, antiviral, antibacterial, anti-osteoporotic, and anti-dental caries properties...
April 16, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29607924/inhibitory-effect-of-epigallocatechin-3-o-gallate-on-octanoylated-ghrelin-levels-in-vitro-and-in-vivo
#4
Kensuke Nakajima, Shigeru Oiso, Hiroko Kariyazono
Ghrelin is an orexigenic peptide hormone produced in the stomach. The major active form is octanoylated ghrelin, which is modified with an n-octanoic acid at the serine-3 residue. Inhibition of octanoylated ghrelin production is useful for the prevention and improvement of obesity. We previously developed a cell-based assay system employing a ghrelin-expressing cell line, AGS-GHRL8, and found various compounds that decreased octanoylated ghrelin levels using this system. (-)-Epigallocatechin-3-O-gallate (EGCG) is a bioactive catechin in green tea and reportedly has an anti-obesity effect; however, it remains unclear whether EGCG inhibits octanoylated ghrelin production...
2018: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29605251/protein-engineering-regulatory-perspectives-of-stearoyl-coa-desaturase
#5
REVIEW
Shagufta Kamal, Ayesha Saleem, Saima Rehman, Ismat Bibi, Hafiz M N Iqbal
Stearoyl Co A desaturase (SCD) is a rate-limiting lipogenic enzyme that plays an integral role in catalyzing the synthesis of monounsaturated fatty acids, chiefly oleate and palmitoleate. Both contribute a major part of the biological membrane. Numerous SCD isoforms exist in mouse and humans, i.e., SCD-1 to SCD-4 and SCD-1 and SCD-5, respectively. From the biological viewpoint, hyperexpression of SCD1 cause many metabolic disorders including obesity, insulin resistance, hypertension, and hypertriglyceridemia, etc...
March 29, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29595075/epigallocatechin-3-gallate-rich-green-tea-extract-ameliorates-fatty-liver-and-weight-gain-in-mice-fed-a-high-fat-diet-by-activating-the-sirtuin-1-and-amp-activating-protein-kinase-pathway
#6
Ui-Jin Bae, John Park, Il Woon Park, Byung Min Chae, Mi-Ra Oh, Su-Jin Jung, Geon-Seek Ryu, Soo-Wan Chae, Byung-Hyun Park
The prevalence of metabolic diseases has risen globally in parallel with the obesity epidemic over the past few decades. Green tea has been reported to have metabolically beneficial effects on obesity; however, the mechanism by which green tea regulates lipid metabolism is not clearly understood. Male c57BL/6 mice were fed a normal chow diet, a high-fat diet (HFD), or an HFD supplemented with various doses of epigallocatechin gallate-rich green tea extract (GTE) for 12 weeks. GTE supplementation reduced body weight gain, prevented hepatic fat accumulation, decreased hypertriglyceridemia, and improved hyperglycemia and insulin resistance in HFD-fed mice...
March 29, 2018: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29525533/maternal-green-tea-polyphenol-intake-during-lactation-attenuates-kidney-injury-in-high-fat-diet-fed-male-offspring-programmed-by-maternal-protein-restriction-in-rats
#7
Saori Kataoka, Toshio Norikura, Shin Sato
Maternal malnutrition is known to increase the risk of obesity in offspring. We investigated whether green tea extract (GTE) intake during lactation affects obesity-related fibrosis and inflammation in the kidney of high-fat-diet-fed adult offspring of protein-restricted-diet-fed dams during pregnancy and lactation. Pregnant Wistar rats received diets containing 20% (normal-protein, NP) or 8% (low-protein, LP) casein, and they received 0%-, 0.12%- or 0.24%-GTE-containing LP diets (LP/LP, LP/LGT and LP/HGT, respectively) during lactation...
February 9, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29484120/epigallocatechin-3-gallate-suppresses-differentiation-of-adipocytes-via-regulating-the-phosphorylation-of-foxo1-mediated-by-pi3k-akt-signaling-in-3t3-l1-cells
#8
Yi Lu, Junye Chen, Tao Xian, Yumeng Zhou, Wanwan Yuan, Mengxi Wang, Yuyang Gan, Kun Wang, Shaofeng Xiong, Cong Ma, Xueying Yu, Qiren Huang
Epigallocatechin-3-gallate (EGCG) is a pivotal effective component of green tea. It is known that EGCG has antioxidant activity, anti-angiogenesis, anti-tumor, cardiovascular protection and blood lipid regulation functions. Forkhead box-O1 (FOXO1) is one of the downstream signals of protein kinase B (AKT) and takes part in adipogenesis. The purpose of this study is to investigate the effects of EGCG on adipose differentiation and the likely mechanisms. 3T3-L1 cells were induced by DMI for 2, 4, 6 and 8 days, respectively...
January 26, 2018: Oncotarget
https://www.readbyqxmd.com/read/29482780/diet-and-supplements-in-cancer-prevention-and-treatment-clinical-evidences-and-future-perspectives
#9
REVIEW
Claudio Vernieri, Federico Nichetti, Alessandra Raimondi, Sara Pusceddu, Marco Platania, Franco Berrino, Filippo de Braud
In recent years, calorie-restricted dietary regimens and compounds such as vitamins, curcumin, green tea extracts and omega-3 fatty acids have attracted attention for their potential anticancer effects. While definitive conclusions cannot be drawn in this field, many patients adopt complementary antitumor therapies aiming to improve efficacy or reduce toxicity of chemotherapy, with uncertain benefits and the risk of additional toxicities or antagonistic interactions with standard therapies. In this manuscript, we review the different levels of available evidence to suggest or discourage specific dietary changes or supplement use in the context of cancer prevention, reduction of tumor recurrences and survival prolongation in advanced cancers...
March 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29482377/green-tea-supplementation-upregulates-uncoupling-protein-3-expression-in-severe-obese-women-adipose-tissue-but-does-not-promote-weight-loss
#10
Driele Cristina Gomes Quinhoneiro, Carolina Ferreira Nicoletti, Marcela Augusta Souza Pinhel, Natália Yumi Noronha, Camila Bitu Moreno Braga, Bruno Affonso Parenti Oliveira, Cristiana Cortes-Oliveira, Wanderley Pereira Oliveira, Wilson Salgado Junior, Júlio Sergio Marchini, Carla Barbosa Nonino
This study aims (i) to verify expression of the UCPs, PLIN1, PPARG2, and ADRB3 genes in the abdominal subcutaneous adipose tissue of obese women at baseline and after 8 weeks of supplementation with decaffeinated green tea extract, and (ii) to associate findings with clinical parameters. This is a longitudinal study during which 11 women with obesity grade III were submitted to supplementation with 450 mg of (-)-epigallocatechin gallate (EGCG) (intervention group); the control group consisted of 10 eutrophic women...
February 26, 2018: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/29476111/protective-effects-of-chinese-fenggang-zinc-selenium-tea-on-metabolic-syndrome-in-high-sucrose-high-fat-diet-induced-obese-rats
#11
Jie Yu, Jing Yang, Mizhuan Li, Xuesong Yang, Pan Wang, Jie Xu
The protective effect of zinc selenium tea against metabolic syndrome (MetS) was tested by using a high-sucrose-high-fat diet (HSHFD)-induced MetS model. Fifty Sprague-Dawley rats were randomly divided into five groups: normal diet (C-group), HSHFD (CH-group), HSHFD + green tea (0.24 g/kg/day) (TH-group), HSHFD + low-dose zinc selenium organic tea (0.24 g/kg/day) (ZTHL-group), and HSHFD + high-dose zinc selenium organic tea (1.20 g/kg/day) (ZTHH-group). After 8 weeks, compared to both the C-group and CH-group, the hepatosomatic index (HI) was significantly reduced in the ZTHL-group (p < 0...
February 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29427445/green-tea-polyphenols-modulate-colonic-microbiota-diversity-and-lipid-metabolism-in-high-fat-diet-treated-hfa-mice
#12
Li Wang, Benhua Zeng, Zhiwei Liu, Zhenlin Liao, Qingping Zhong, Lihui Gu, Hong Wei, Xiang Fang
There is an increasing interest in the effect of dietary polyphenols on the intestinal microbiota and the possible associations between this effect and the development of obesity. However, limited information is available on how these polyphenols affect the gut microbiota and lipid metabolism. The co-action of a high-fat diet (HFD) and tea polyphenol (TP) on gut microbiota and lipid metabolism using a human flora-associated (HFA) C57BL/6J mice model is studied. TP reduced serum total cholesterol, triglyceride, low density lipoprotein, glucose (GLU) and insulin (INS) levels of HFD mice in a dose-dependent manner (P < 0...
March 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29426328/feasibility-and-acceptability-of-a-beverage-intervention-for-hispanic-adults-a-protocol-for-a-pilot-randomized-controlled-trial
#13
Kristin E Morrill, Benjamin Aceves, Luis A Valdez, Cynthia A Thomson, Iman A Hakim, Melanie L Bell, Jessica A Martinez, David O Garcia
BACKGROUND: In the U.S., Hispanics have among the highest rates of overweight and obesity when compared to other racial/ethnic groups placing them at a greater risk for obesity-related disease. Identifying intervention strategies to reduce caloric intake and/or improve cardiometabolic health in Hispanics is critical to reducing morbidity and mortality among this large and growing population. Evidence exists to support diet-specific behavioral interventions, including beverage modifications, in reducing obesity-related health risks...
February 9, 2018: Nutrition Journal
https://www.readbyqxmd.com/read/29423494/egcg-evokes-nrf2-nuclear-translocation-and-dampens-ptp1b-expression-to-ameliorate-metabolic-misalignment-under-insulin-resistance-condition
#14
Yashi Mi, Wentong Zhang, Haoyu Tian, Runnan Li, Shuxian Huang, Xingyu Li, Guoyuan Qi, Xuebo Liu
As a major nutraceutical component of green tea (-)-epigallocatechin-3-gallate (EGCG) has attracted interest from scientists due to its well-documented antioxidant and antiobesity bioactivities. In the current study, we aimed to investigate the protective effect of EGCG on metabolic misalignment and in balancing the redox status in mice liver and HepG2 cells under insulin resistance condition. Our results indicated that EGCG accelerates the glucose uptake and evokes IRS-1/Akt/GLUT2 signaling pathway via dampening the expression of protein tyrosine phosphatase 1B (PTP1B)...
March 1, 2018: Food & Function
https://www.readbyqxmd.com/read/29415825/green-tea-extract-outperforms-metformin-in-lipid-profile-and-glycaemic-control-in-overweight-women-a-double-blind-placebo-controlled-randomized-trial
#15
Monallisa Alves Ferreira, Anna Paula Oliveira Gomes, Ana Paula Guimarães de Moraes, Maria Luiza Ferreira Stringhini, João Felipe Mota, Alexandre Siqueira Guedes Coelho, Patrícia Borges Botelho
BACKGROUND & AIMS: Both green tea and metformin are used as adjuvants to treat and prevent complications associated with obesity; however, studies comparing their action and interaction in non-diabetic overweight women have not been reported. Thus, the current study evaluated the effects of green tea extract and metformin, both individually and in combination, on type 2 diabetes risk factors in non-diabetic overweight women. METHODS: A total of 120 overweight women were randomly assigned in a double-blind manner to 1 of 4 groups, as follows: control (n = 29; 1 g of cellulose), green tea (n = 32; 1 g of dry green tea extract), metformin (n = 28; 1 g of metformin), and green tea + metformin (n = 31; 1 g of dry green tea extract + 1 g of metformin)...
December 2017: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29280418/comparative-effect-of-camellia-sinensis-teas-on-object-recognition-test-deficit-and-metabolic-changes-induced-by-cafeteria-diet
#16
Melina Bucco Soares, Juliana Bernera Ramalho, Aryele Pinto Izaguirry, Natasha Frasson Pavin, Cristiano Chiapinotto Spiazzi, Helen Lidiane Schimidt, Pâmela Billig Mello-Carpes, Francielli Weber Santos
OBJECTIVES: Consumption of high-fat and high-sugar diets in Western countries has increased significantly causing major global health problems including metabolic syndrome and obesity. In addition, studies have suggested that obesity can lead to learning and memory deficits. In this context, the use of natural compounds with low costs, minor side effects and increased antioxidant activity, such as teas, could reduce the damages induced by obesity. We investigated the effect of white, green, red, and black teas (Camellia sinensis) and their possible neuroprotective mechanisms in an experimental obesity model induced by a cafeteria diet (CD)...
December 27, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29232928/beverage-consumption-patterns-among-overweight-and-obese-african-american-women
#17
Terryl J Hartman, Regine Haardörfer, Brenda M Greene, Shruti Parulekar, Michelle C Kegler
The goal of this research was to assess patterns of beverage consumption and the contribution of total beverages and classes of beverages to overall energy intake and weight status. We conducted an analysis in a community-based study of 280 low-income overweight and obese African American women residing in the rural South. Participants provided baseline data including demographic characteristics, weight and two 24-h food and beverage dietary recalls. Mean energy intake from beverages was approximately 273 ± 192 kcal/day or 18...
December 11, 2017: Nutrients
https://www.readbyqxmd.com/read/29228755/long-term-supplementation-of-decaffeinated-green-tea-extract-does-not-modify-body-weight-or-abdominal-obesity-in-a-randomized-trial-of-men-at-high-risk-for-prostate-cancer
#18
Nagi B Kumar, Roshni Patel, Julio Pow-Sang, Philippe E Spiess, Raoul Salup, Christopher R Williams, Michael J Schell
Background: Evidence continues to demonstrate the role of obesity in prostate carcinogenesis and prognosis, underscoring the need to identify and continue to evaluate the effective interventions to reduce obesity in populations at high risk. The aim of the study was to determine the effect of daily consumption of decaffeinated green tea catechins (GTC) formulation (Polyphenon E® (PolyE)) for 1 year on biomarkers of obesity in men who are at high risk for prostate cancer. Materials and Methods: A randomized, double-blinded trial was conducted targeting 97 men diagnosed with HGPIN or ASAP...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29190550/green-tea-extract-protects-against-hepatic-nf%C3%AE%C2%BAb-activation-along-the-gut-liver-axis-in-diet-induced-obese-mice-with-nonalcoholic-steatohepatitis-by-reducing-endotoxin-and-tlr4-myd88-signaling
#19
Jinhui Li, Geoffrey Y Sasaki, Priyankar Dey, Chureeporn Chitchumroonchokchai, Allison N Labyk, Joshua D McDonald, Joshua B Kim, Richard S Bruno
Green tea extract (GTE) reduces NFκB-mediated inflammation during nonalcoholic steatohepatitis (NASH). We hypothesized that its anti-inflammatory activities would be mediated in a Toll-like receptor 4 (TLR4)-dependent manner. Wild-type (WT) and loss-of-function TLR4-mutant (TLR4m) mice were fed a high-fat diet containing GTE at 0 or 2% for 8 weeks before assessing NASH, NFκB-mediated inflammation, TLR4 and its adaptor proteins MyD88 and TRIF, circulating endotoxin, and intestinal tight junction protein mRNA expression...
March 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29175576/potential-role-of-the-mitochondria-as-a-target-for-the-hepatotoxic-effects-of-epigallocatechin-3-gallate-in-mice
#20
Karma D James, Mary J Kennett, Joshua D Lambert
Green tea and (-)-epigallocatechin-3-gallate (EGCG) have been studied for their obesity-related health effects. Many green tea extract (GTE)-based dietary supplements are commercially-available. Although green tea beverage has a long history of safe use, a growing number of case-reports have linked GTE-based supplements to incidents of hepatotoxicity. Animal studies support the hepatotoxic potential of GTE and EGCG, but the mechanisms remain unclear. Here, we examined the hepatotoxic effects of EGCG in C57BL/6J mice and evaluated changes in hepatic antioxidant response and mitochondria structure and function...
January 2018: Food and Chemical Toxicology
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