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https://www.readbyqxmd.com/read/29783263/monitoring-of-efficiency-of-dental-caries-management-in-children-s-temporary-teeth-throughout-poltava-oblast
#1
Olha V Sheshukova, Valentina P Trufanova, Tetiana V Polishchuk, Kateryna S Kazakova, Sofiya S Bauman, Natalia A Lyakhova, Iryna M Tkachenko
OBJECTIVE: Introduction: Dental caries is still a major health care problem not only in Ukraine but throughout the world. Complicated dental caries currently ranks the leading position among the oral diseases in children. The aim of this study is to carry out a analysis of the epidemiology of dental caries and its complications, and to evaluate the efficiency of the caries treatment for temporary teeth among the children of Poltava oblast over the last decade based on the data of the annual reports...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783234/-myocardial-bridge-as-the-only-cause-of-acute-coronary-syndrome-among-the-young-patients
#2
Liudmila O Miakinkova, Yurii V Teslenko, Irina V Tsyhanenko
OBJECTIVE: Introduction: Myocardial bridge is an inborn anomaly of coronary artery development, when a part of it is submerged in a myocard, which is pressing the coronary artery to a systola and restrains coronary blood circulation. Generally this feature of coronary blood circulation does not cause any clinical symptoms because the 85% of coronary blood stream of the left ventricle is provided by diastolic filling. Hemodynamic changes in atherosclerosis, tahicardie, hypertrophie of myocard are leading to the manifestation of clinical symptoms of ischemia...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783229/-morphological-characteristics-of-kidneys-connective-tissue-of-mature-fetuses-and-newborns-from-mothers-whose-pregnancy-was-complicated-by-preeclampsia-of-varying-degrees-of-severity
#3
Iryna V Sorokina, Mykhailo S Myroshnychenko, Nataliia V Kapustnyk, Tetyana O Khramova, Oksana V Dehtiarova, Svitlana I Danylchenko
OBJECTIVE: Introduction: The kidneys connective tissue condition in the antenatal period affects the formation of tissues and it changes with the development of various general pathological processes in this organ. The aim of the study was to identify the morphological features of kidneys connective tissue of fetuses and newborns from mothers whose pregnancy was complicated by preeclampsia of varying degrees of severity. PATIENTS AND METHODS: Materials and methods: The material of the study was the tissue of kidneys of mature fetuses and newborns from mothers with physiological pregnancy (28 cases), as well as from mothers whose pregnancy was complicated by preeclampsia of varying degrees of severity (78 cases)...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783206/-experimental-evaluation-of-the-therapeutic-potential-of-liposome-mediated-apoe3-gene-transfection-for-cerebral-atherosclerosis
#4
Vadym V Biloshytskyi, Alisa V Pachevska, Alina V Biloshytska, Valerii M Istoshyn, Maryna V Biloshytska, Olha B Shevnia
OBJECTIVE: Introduction: In recent years, a stroke has been the cause of high lethality, long-term and sustained disability, the problem of which is still far from being resolved. The root cause of stroke is atherosclerosis. The aim: Study of neurotrophic and neuroprotective functions of apoE in rat brain tissue in experimental atherosclerosis. PATIENTS AND METHODS: Materials and methods: The study included 60 sexually mature rats. The model of experimental atherosclerosis was created by Anichkov method...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783192/interaction-of-dna-and-mononucleotides-with-theophylline-investigated-using-electrochemical-biosensors-and-biosensing
#5
Katarína Nemčeková, Ján Labuda, Viktor Milata, Jana Blaškovičová, Jozef Sochr
The understanding of DNA-drug interaction mechanism is among the important aspects of biological studies for drug design, discovery and pharmaceutical development processes. Published rather detailed FTIR and UV-visible spectroscopic studies on the interactions of theophylline, theobromine and caffeine with calf thymus DNA have shown effective binding of these methylxanthine derivatives to DNA and RNA involving H-bonds. However, to our knowledge, there is no such investigation using electrochemical approach...
May 3, 2018: Bioelectrochemistry
https://www.readbyqxmd.com/read/29783181/autistic-traits-in-epilepsy-models-why-when-and-how
#6
REVIEW
Jana Velíšková, Jill L Silverman, Melissa Benson, Pierre-Pascal Lenck-Santini
Autism spectrum disorder (ASD) is a common comorbidity of epilepsy and seizures and/or epileptiform activity are observed in a significant proportion of ASD patients. Current research also implies that autistic traits can be observed to a various degree in mice and rats with seizures. This suggests that there are shared mechanisms in both ASD and epilepsy syndromes. Here, we first review the standard, validated methods used to assess autistic traits in animal models as well as their limitations with regards to epilepsy models...
May 18, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29783099/leveraging-the-cruzain-s3-subsite-to-increase-affinity-for-reversible-covalent-inhibitors
#7
Lorenzo Cianni, Geraldo Sartori, Fabiana Rosini, Daniela De Vita, Gabriel Pires, Bianca Rebelo Lopes, Andrei Leitão, Antonio C B Burtoloso, Carlos A Montanari
Cruzain is the major cysteine protease of Trypanosoma cruzi, the etiological agent of Chagas disease. Reversible covalent cruzain inhibitors can block the steps of cell differentiation in the parasite and kill the organism. To this end, the description of how inhibitors modified at the P2/P3 positions lead to analogs with greater cruzain affinity to the S2/S3 subsites is of fundamental importance. Albeit many efforts are being employed in the characterization of the interaction processes with S2 subsite, little is known about the cruzain S3 subsite...
April 26, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29783043/developmental-changes-in-the-perception-of-visuotactile-simultaneity
#8
Yi-Chuan Chen, Terri L Lewis, David I Shore, Charles Spence, Daphne Maurer
A simultaneity judgment (SJ) task was used to measure the developmental trajectory of visuotactile simultaneity perception in children (aged 7, 9, 11, and 13 years) and adults. Participants were presented with a visual flash in the center of a computer monitor and a tap on their right index finger (located 20° below the flash) with 13 possible stimulus onset asynchronies (SOAs). Participants reported whether the flash and tap were presented at the same time. Compared with the adult group, children aged 7 and 9 years made more simultaneous responses when the tap led by more than 300 ms and when the flash led by more than 200 ms, whereas they made fewer simultaneous responses at the 0 ms SOA...
May 18, 2018: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/29782835/multi-pronged-interactions-underlie-inhibition-of-%C3%AE-synuclein-aggregation-by-%C3%AE-synuclein
#9
Jonathan K Williams, Xue Yang, Tamr B Atieh, Michael P Olson, Sagar D Khare, Jean Baum
The intrinsically disordered protein β-synuclein is known to inhibit the aggregation of its intrinsically disordered homolog, α-synuclein, which is implicated in Parkinson's disease. While β-synuclein itself does not form fibrils at the cytoplasmic pH7.4, alteration of pH and other environmental perturbations are known to induce its fibrilization. However, the sequence and structural determinants of β-synuclein inhibition and self-aggregation are not well understood. We have utilized a series of domain-swapped chimeras of α-synuclein and β-synuclein to probe the relative contributions of the N-terminal, C-terminal and the central Non-Amyloid-β Component (NAC) domains to the inhibition of α-synuclein aggregation...
May 18, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29782823/changing-the-site-energy-of-per-614-in-the-peridinin-chlorophyll-a-protein-does-not-alter-its-capability-of-chlorophyll-triplet-quenching
#10
Alessandro Agostini, Jens Niklas, Tim Schulte, Marilena Di Valentin, Marco Bortolus, Eckhard Hofmann, Wolfgang Lubitz, Donatella Carbonera
The peridinin-chlorophyll-a protein (PCP) is a water-soluble light harvesting protein of the dinoflagellate Amphidinium carterae, employing peridinin (Per) as the main carotenoid to fulfil light harvesting and photo-protective functions. Per molecules bound to the protein experience specific molecular surroundings which lead to different electronic and spectral properties. In the refolded N89 L variant PCP (N89 L-RFPCP) a significant part of the intensity on the long wavelength side of the absorption spectrum is shifted to shorter wavelengths due to a significant change in the Per-614 site energy...
May 18, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29782792/antimicrobial-properties-of-2d-mno-2-and-mos-2-nanomaterials-vertically-aligned-on-graphene-materials-and-ti-3-c-2-mxene
#11
Farbod Alimohammadi, Mohammad Sharifian Gh, Nuwan H Attanayake, Akila C Thenuwara, Yury Gogotsi, Babak Anasori, Daniel R Strongin
Two dimensional (2D) nanomaterials have attracted considerable attention in biomedical and environmental applications due to their antimicrobial activity. In the interest of investigating the primary antimicrobial mode-of-action of 2D nanomaterials, we studied the antimicrobial properties of MnO2 and MoS2 , toward Gram-positive and Gram-negative bacteria. Bacillus subtilis and Escherichia coli bacteria were treated individually with 100 μg/mL of randomly oriented and vertically aligned nanomaterials for 3 h in the dark...
May 21, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29782667/synergies-of-electrochemical-metallization-and-valance-change-in-all-inorganic-perovskite-quantum-dots-for-resistive-switching
#12
Yan Wang, Ziyu Lv, Qiufan Liao, Haiquan Shan, Jinrui Chen, Ye Zhou, Li Zhou, Xiaoli Chen, Vellaisamy A L Roy, Zhanpeng Wang, Zongxiang Xu, Yu-Jia Zeng, Su-Ting Han
The in-depth understanding of ions' generation and movement inside all-inorganic perovskite quantum dots (CsPbBr3 QDs), which may lead to a paradigm to break through the conventional von Neumann bottleneck, is strictly limited. Here, it is shown that formation and annihilation of metal conductive filaments and Br- ion vacancy filaments driven by an external electric field and light irradiation can lead to pronounced resistive-switching effects. Verified by field-emission scanning electron microscopy as well as energy-dispersive X-ray spectroscopy analysis, the resistive switching behavior of CsPbBr3 QD-based photonic resistive random-access memory (RRAM) is initiated by the electrochemical metallization and valance change...
May 21, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29782639/sudden-cardiac-death-in-athletes-and-the-value-of-cardiovascular-magnetic-resonance
#13
REVIEW
Sophie I Mavrogeni, Flora Bacopoulou, Despoina Apostolaki, George P Chrousos
Sudden cardiac death (SCD) is the non-traumatic death, due to loss of heart function that occurs suddenly and unexpectedly within 6 hours of a previously normal state of health. It is related to intense competitive sports promoting ventricular tachycardia (VT)/ventricular fibrillation (VF) in the presence of underlying abnormal substrate. A serial evaluation of cardiac physiologic changes taking place during training will allow the better understanding of athlete's heart and will facilitate its discrimination from other gray-zone cardiomyopathies...
May 21, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29782516/how-a-smiley-protects-health-a-pilot-intervention-to-improve-hand-hygiene-in-hospitals-by-activating-injunctive-norms-through-emoticons
#14
Susanne Gaube, Dimitrios Tsivrikos, Daniel Dollinger, Eva Lermer
Hand hygiene practice in hospitals is unfortunately still widely insufficient, even though it is known that transmitting pathogens via hands is the leading cause of healthcare-associated infections. Previous research has shown that improving knowledge, providing feedback on past behaviour and targeting social norms are promising approaches to improve hand hygiene practices. The present field experiment was designed to direct people on when to perform hand hygiene and prevent forgetfulness. This intervention is the first to examine the effect of inducing injunctive social norms via an emoticon-based feedback system on hand hygiene behaviour...
2018: PloS One
https://www.readbyqxmd.com/read/29782503/impact-and-recovery-process-of-mini-flash-crashes-an-empirical-study
#15
Tobias Braun, Jonas A Fiegen, Daniel C Wagner, Sebastian M Krause, Thomas Guhr
In an Ultrafast Extreme Event (or Mini Flash Crash), the price of a traded stock increases or decreases strongly within milliseconds. We present a detailed study of Ultrafast Extreme Events in stock market data. In contrast to popular belief, our analysis suggests that most of the Ultrafast Extreme Events are not necessarily due to feedbacks in High Frequency Trading: In at least 60 percent of the observed Ultrafast Extreme Events, the largest fraction of the price change is due to a single market order. In times of financial crisis, large market orders are more likely which leads to a significant increase of Ultrafast Extreme Events occurrences...
2018: PloS One
https://www.readbyqxmd.com/read/29782376/regulations-rules-and-laws-leading-through-the-changes
#16
Hector M de Jesus
No abstract text is available yet for this article.
2018: Frontiers of Health Services Management
https://www.readbyqxmd.com/read/29782373/compliance-and-high-reliability-in-a-complex-healthcare-organization
#17
Maxine dellaBadia Simon
When considering the impact of regulation on healthcare, visualize a spider's web. The spider weaves sections together to create the whole, with each fiber adding to the structure to support its success or lead to its failure. Each section is dependent on the others, and all must be aligned to maintain the structure. Outside forces can cause a shift in the web's fragile equilibrium.The interdependence of the sections of the spider's web is similar to the way hospital departments and services work together. An organization's structure must be shaped to support its mission and vision...
2018: Frontiers of Health Services Management
https://www.readbyqxmd.com/read/29782317/dementia-research-populations-progress-problems-and-predictions
#18
Sally Hunter, Nadja Smailagic, Carol Brayne
Alzheimer's disease (AD) is a clinicopathologically defined syndrome leading to cognitive impairment. Following the recent failures of amyloid-based randomized controlled trials to change the course of AD, there are growing calls for a re-evaluation of basic AD research. Epidemiology offers one approach to integrating the available evidence. Here we examine relationships between evidence from population-based, clinicopathological studies of brain aging and a range of hypotheses from all areas of AD research...
May 16, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29782308/activation-of-herpes-simplex-infection-after-tattoo
#19
Antigona Begolli Gerqari, Mybera Ferizi, Merita Kotori, Aferdita Daka, Syzana Hapciu, Ilir Begolli, Mirije Begolli, Idriz Gerqari
Tattooing is a procedure where ink is applied to an area of the skin, mostly intraepidermally (1). This procedure is carried out mainly for aesthetic purposes. Lately, it has been used as a corrective medical procedure following amputation of mammilla. The procedure is aggressive (2), and the fact that skin is punctured many times with the same needle which cannot be fully sterilized may cause infection of the treated area with bacterial, fungal, or viral agents that may lead to health consequences manifesting in the form of verrucae vulgaris, molluscum contagiosum, and herpes simplex...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29782307/cutaneous-manifestations-of-tuberous-sclerosis
#20
Mirjana Bakić, Marina Ratković, Branka Gledović, Balsa Vujović, Danilo Radunović, Vera Babić, Vladimir Prelević
Dear Editor, Tuberous sclerosis (TS) is an autosomal dominant multisystem disease, which occurs due to genetically determined hyperplasia of ectodermal and mesodermal cells. Clinical manifestations present on the skin and in the nervous system, kidneys, heart, and other organs. Recent studies estimate the incidence of TS at 1/6000 to 1/10,000 live births, and a prevalence in the general population of approximately 1 in 20,000 (1). There are two different genetic loci responsible for TS: 9q34 (TSC1-hamartin) and 16p13...
April 2018: Acta Dermatovenerologica Croatica: ADC
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