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https://www.readbyqxmd.com/read/29353391/detection-of-sleep-disordered-breathing-with-ambulatory-holter-monitoring
#1
Ian Grasso, Mark Haigney, David Mortara, Jacob F Collen, Jordanna Hostler, Aimee Moores, Karen Sheikh, William Kelly
PURPOSE: Obstructive sleep apnea (OSA) syndrome is a common condition that can impact clinical outcomes among patients with cardiovascular disease. Screening all subjects with heart disease via polysomnography (PSG) is costly and resource-limited. We sought to compare a Holter monitor-based algorithm to detect OSA to in-laboratory polysomnography (PSG). METHODS: Prospective cohort study of patients undergoing in-laboratory attended PSG for the evaluation of OSA...
January 20, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29353227/the-natural-history-of-phytosterolemia-observations-on-its-homeostasis
#2
David Mymin, Gerald Salen, Barbara Triggs-Raine, Darrel J Waggoner, Thomas Dembinski, Grant M Hatch
BACKGROUND AND AIMS: Phytosterolemia is a rare genetic disease caused by mutation of the ABCG5/8 gene. Our aim was to elucidate the natural history and homeostasis of phytosterolemia. METHODS: We analyzed a Hutterite kindred consisting of 21 homozygotes with phytosterolemia assembled over a period of two decades, all of whom carried the ABCG8 S107X mutation and were treated with ezetimibe. RESULTS: Most of these subjects were asymptomatic and devoid of clinical stigmata, and this, since they were ascertained primarily by a process of cascade testing, suggests that, relative to its true prevalence, phytosterolemia is a condition of low morbidity...
December 28, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29353166/toxicological-responses-on-cytochrome-p450-and-metabolic-transferases-in-liver-of-goldfish-carassius-auratus-exposed-to-lead-and-paraquat
#3
Xiaoming Xu, Zhaojie Cui, Xinlei Wang, Xixin Wang, Su Zhang
As the producer of reactive oxygen species (ROS), both lead (Pb) and paraquat (PQ) can generate serious oxidative stress in target organs which result in irreversible toxic effects on organisms. They can disturb the normal catalytic activities of many enzymes by means of different toxicity mechanism. The changed responses of enzymes are frequently used as the biomarkers for indicating the relationship between toxicological effects and exposure levels. In this work, goldfish was exposed to a series of test groups containing lead and paraquat in the range of 0...
January 17, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29353150/biodegradable-spacer-reduces-the-subacromial-pressure-a-biomechanical-cadaver-study
#4
Yan Chevalier, Matthias F Pietschmann, Christoph Thorwächter, Ofir Chechik, Eliyahu Adar, Assaf Dekel, Peter E Müller
BACKGROUND: Failure after rotator cuff repair remains a major clinical problem and could be related to excessive pressures from the acromion. Previous studies with irreparable tears showed good clinical results of tendon healing with arthroscopic insertion of a protective biodegradable spacer balloon between the repaired tendon and the acromion. One hypothesis is that compression pressures on the repaired tendon will be reduced by the spacer. This cadaver study aimed to investigate the effects of this subacromial spacer on compression pressures over a repaired supraspinatus tendon in passive motion...
December 18, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/29353145/extremely-low-frequency-electromagnetic-field-emf-generates-alterations-in-the-synthesis-and-secretion-of-oestradiol-17%C3%AE-e2-in-uterine-tissues-an-in%C3%A2-vitro-study
#5
Anna Koziorowska, Ewa Monika Waszkiewicz, Maria Romerowicz-Misielak, Kamila Zglejc-Waszak, Anita Franczak
An electromagnetic field (EMF) of extremely low frequency may affect physiological processes in mammals. The aim of the present study was to determine the effect of an EMF on the synthesis and secretion of oestradiol-17β (E2) in the porcine uterus. Endometrial and myometrial slices were harvested on days 12-13 of the oestrous cycle and exposed in vitro to an EMF (50 and 120 Hz, 8 mT) for 2 and 4 h in the presence or absence of progesterone (P4). Subsequently, the incubation media were used to determine the concentration of E2 with RIA...
January 9, 2018: Theriogenology
https://www.readbyqxmd.com/read/29353077/classification-of-heterogeneous-genetic-variations-of-microrna-regulome-in-cancer
#6
Karin Hrovatin, Tanja Kunej
Genetic variations and differential expression of miRNA regulome components are associated with cancer. Thus miRNA based diagnosis and treatments have been proposed. However, to better explore these options, the molecular changes in miRNA regulome must be understood. MicroRNAs can be involved in regulation of oncogenes and tumour suppressors. As each miRNA targets broad range of genes, minor changes in miRNAs can have great effects, contributing to cell transformation. Many genetic variants of miRNA regulome have been reported to be associated with cancer, but this information needs to be systematized...
January 15, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29353052/evidence-for-altered-insulin-receptor-signaling-in-alzheimer-s-disease
#7
REVIEW
Chelsea M Griffith, Tore Eid, Gregory M Rose, Peter R Patrylo
Epidemiological data have shown that metabolic disease can increase the propensity for developing cognitive decline and dementia, particularly Alzheimer's disease (AD). While this interaction is not completely understood, clinical studies suggest that both hyper- and hypoinsulinemia are associated with an increased risk for developing AD. Indeed, insulin signaling is altered in post-mortem brain tissue from AD patients and treatments known to enhance insulin signaling, can improve cognitive function. Further, clinical evidence has shown that AD patients and mouse models of AD often display alterations in peripheral metabolism...
January 15, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29353014/neuroprotective-effect-of-morin-on-lead-acetate-induced-apoptosis-by-preventing-cytochrome-c-translocation-via-regulation-of-bax-bcl-2-ratio
#8
Sumathi Thangarajan, Aishwarya Vedagiri, Shanmathy Somasundaram, Rathika Sakthimanogaran, Mahalakshmi Murugesan
Lead (Pb) intoxication is a prevalent type of environmental toxicity as well as minimal amount of lead exposure is liable for neurobehavioral or perhaps intelligence defects. The present study was undertaken to investigate the beneficial effects of morin in protecting the lead acetate (PbAc)-induced oxidative stress in rat brain. PbAc intoxication resulted in motor deficit, memory impairment and oxidative stress Further, PbAc administration alters Bax/Bcl-2 expression thereby increases cytochrome c release from the mitochondria...
January 15, 2018: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/29352966/polyphyllin-g-exhibits-antimicrobial-activity-and-exerts-anticancer-effects-on-human-oral-cancer-oecm-1-cells-by-triggering-g2-m-cell-cycle-arrest-by-inactivating-cdc25c-cdc2
#9
Xiaoqing Cai, Lele Guo, Fei Pei, Xiaoyun Chang, Rui Zhang
Plant natural products have long been considered to be important sources of bioactive molecules. A large number of antimicrobial and anticancer agents have been isolated form plants. In the present study we evaluated the antimicrobial and anticancer activity of a plant derived secondery metabolite, Polyphyllin G. The results of antibacterial assays showed that Polyphyllin G prevented the growth of both Gram-positive and Gram-negative bacteria with minimum inhibitory concentrations (MICs) ranging from 13.1 to 78 μg/ml...
January 15, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29352962/improved-systemic-metabolism-and-adipocyte-biology-in-mir-150-knockout-mice
#10
Minsung Kang, Xiaobing Liu, Yuchang Fu, W Timothy Garvey
INTRODUCTION: Short non-coding micro-RNAs (miRNAs) are post-transcriptional factors that directly regulate protein expression by degrading or inhibiting target mRNAs; however, the role of miRNAs in obesity and cardiometabolic disease remains unclarified. Based on our earlier study demonstrating that miR-150 influences lipid metabolism, we have studied effects of miR-150 on systemic metabolism and adipocyte biology. MATERIALS AND METHODS: Metabolic phenotypes including body weight, food intake, body composition, glucose tolerance and insulin sensitivity were assessed in WT and global miR-150 KO male mice fed a high-fat diet...
January 15, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29352910/a-novel-photocleavable-heparin-derivative-with-light-controllable-anticoagulant-activity
#11
Feifei Sun, Yinyin Liu, Dongdong Wang, Zhaojie Wang, Haibo Mu, Feng Wang, Kan Ding, Jinyou Duan
Heparin (HP) has enormous potential for clinical medication applications owing to its anticoagulant activity. However, the strong anticoagulant capacity of HP also leads to some side effects. Herein, a photocaged derivative (HP-DMNB) of HP was synthesized for light control of its anticoagulant activity. The synthesized HP-DMNB was characterized by NMR and FTIR analysis, which confirmed the successful modification of HP with the photocleavable 4,5-dimethoxyl-2-nitrobenzyl (DMNB) groups. After the modification, the molecular weight of HP-DMNB (DS = 0...
March 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29352811/single-nucleotide-polymorphisms-in-genes-encoding-penicillin-binding-proteins-in-%C3%AE-lactamase-negative-ampicillin-resistant-haemophilus-influenzae-in-japan
#12
Kazuhisa Misawa, Norihito Tarumoto, Shinsuke Tamura, Morichika Osa, Takaaki Hamamoto, Atsushi Yuki, Yuji Kouzaki, Kazuo Imai, Runtuwene Lucky Ronald, Toshiyuki Yamaguchi, Takashi Murakami, Shigefumi Maesaki, Yutaka Suzuki, Akihiko Kawana, Takuya Maeda
OBJECTIVE: β-Lactamase-negative ampicillin-resistant Haemophilus influenzae is a common opportunistic pathogen of hospital- and community-acquired infections, harboring multiple single nucleotide polymorphisms in the ftsI gene, which codes for penicillin-binding protein-3. The objectives of this study were to perform comprehensive genetic analyses of whole regions of the penicillin-binding proteins in H. influenzae and to identify additional single nucleotide polymorphisms related to antibiotic resistance, especially to ampicillin and other cephalosporins...
January 20, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29352786/from-elemental-tellurium-to-ge2sb2te5-melts-high-temperature-dynamic-and-relaxation-properties-in-relationship-with-the-possible-fragile-to-strong-transition
#13
H Flores-Ruiz, M Micoulaut
We investigate the dynamic properties of Ge-Sb-Te phase change melts using first principles molecular dynamics with a special emphasis on the effect of tellurium composition on melt dynamics. From structural models and trajectories established previously [H. Flores-Ruiz et al., Phys. Rev. B 92, 134205 (2015)], we calculate the diffusion coefficients for the different species, the activation energies for diffusion, the Van Hove correlation, and the intermediate scattering functions able to substantiate the dynamics and relaxation behavior of the liquids as a function of temperature and composition that is also compared to experiment whenever possible...
January 21, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29352772/neurotransmitters-and-receptors-changes-in-medial-nucleus-of-the-trapezoid-body-mntb-of-early-developmental-rats-with-single-side-deafness
#14
Jinsheng Dai, Jinfeng Liu, Mo Zhou, Wenjiao Wang, Zhi-Qing David Xu, Ningyu Wang
BACKGROUND Congenital single-side deafness (SSD) affects sound localization even after cochlear implantation (CI) in some conditions. The medial nucleus of the trapezoid body (MNTB) plays an important role in binaural benefit and sound localization, but little is known about intrinsic molecular changes in MNTB with SSD. We aimed to observe changes in MNTB in early-developmental SSD rats, including the key neurotransmitters (GABA, Gly, Glu) and major receptors (GABAa-R/GABAb-R for GABA, Gly-R for Gly, and AMPA/NMDA for Glu)...
January 20, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29352497/redox-potential-an-intrinsic-parameter-of-the-rumen-environment
#15
REVIEW
Y Huang, J P Marden, C Julien, C Bayourthe
The ruminal ecosystem is a fermentative milieu which is interesting to discuss in terms of its redox status as a reflection of an intense bacterial activity. The objective of this systematic literature review is to quantitatively analyze data collected on redox potential (Eh) in the rumen and to explore relationship between ruminal Eh, nature of the diet fed to ruminants, and ruminal fermentation parameters. Data obtained from 15 studies comprising 24 different diets was used in the analysis. Studies included in the data file were selected based on the criteria of: (i) the nature of the reference electrode was specified, (ii) the ruminal Eh was recorded simultaneously to pH, (iii) animal body weight (BW) and dry matter intake (DMI) were reported and (iv) the composition of the diet was precisely described...
January 19, 2018: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29352423/understanding-and-addressing-hair-disorders-in-transgender-individuals
#16
REVIEW
Yi Gao, Toby Maurer, Paradi Mirmirani
In the United States, an increasing number of individuals are identifying as transgender. Males at birth who identify as females are called male-to-female (MTF) transgender individuals or trans women, and females at birth who identify as males are called female-to-male (FTM) transgender individuals or trans men. The transgender patient population possess unique health concerns disparate from those of the general populace. Exogenous hormone therapy for transgender patients leads to changes in the distribution and pattern of hair growth...
January 19, 2018: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29352420/diagnosis-and-management-of-hepatitis-c-infection-in-primary-care-settings
#17
Debra Guss, Jagannath Sherigar, Paul Rosen, Smruti R Mohanty
Hepatitis C virus (HCV) infection is a significant health problem worldwide, and is the leading cause of cirrhosis, hepatocellular carcinoma, and liver transplantation in the United States. The management of HCV has changed significantly over the last 5 years, as treatments have become simpler and more efficacious. Medication efficacy is now greater than 90%, with a high barrier to resistance and few side effects. This review is a collaboration between primary care and hepatology providers to explore all aspects of HCV management: acute versus chronic HCV infection, transmission and testing, and diagnosis and treatment...
January 19, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29352419/a-systematic-review-of-interventions-to-follow-up-test-results-pending-at-discharge
#18
Patrick J Darragh, T Bodley, A Orchanian-Cheff, K G Shojania, J L Kwan, P Cram
BACKGROUND: Patients are frequently discharged from the hospital before all test results have been finalized. Thirty to 40% of tests pending at discharge (TPADs) return potentially actionable results that could necessitate change in the patients' management, often unbeknownst to their physicians. Delayed follow-up of TPADs can lead to patient harm. We sought to synthesize the existing literature on interventions intended to improve the management of TPADs, including interventions designed to enhance documentation of TPADs, increase physician awareness when TPAD results finalize post-discharge, decrease adverse events related to missed TPADs, and increase physician satisfaction with TPAD management...
January 19, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29352369/analysis-of-the-succession-of-structure-of-the-bacteria-community-in-soil-from-long-term-continuous-cotton-cropping-in-xinjiang-using-high-throughput-sequencing
#19
Zhang Wei, Du Yu
The present study aimed to identify the structural succession of the bacteria community in soil during long-term continuous cotton cropping and its relationship with continuous cropping obstacles in Xinjiang, China. High-throughput sequencing was used to analyze and compare the composition of the bacterial community in the soil at the cotton root zone after years of continuous cotton cropping and crop rotation over 30 years of cultivation. Cotton cultivation increased the structural diversity of the bacterial community, among which the populations of Actinobacteria, Acidobacteria, Firmicutes, Nitrospirae, and Chloroflexi changed considerably...
January 19, 2018: Archives of Microbiology
https://www.readbyqxmd.com/read/29352365/-anesthesia-problem-cards-indispensable-yet-problematic-nationwide-survey-on-experiences-from-clinical-practice
#20
M Schieren, A Böhmer, W Golbeck, J Defosse, F Wappler, H E Marcus
BACKGROUND: Anesthetic procedures may lead to severe and potentially life-threatening complications (e. g. difficult airway, allergic reactions, malignant hyperthermia). Most complications can be avoided in future anesthetic procedures with adequate preparation (e. g. awake intubation, trigger-free anesthesia). In Germany, anesthesia problem cards were introduced two decades ago to identify patients at risk and to increase patient safety by creating a standardized documentation system for anesthesia-related complications...
January 19, 2018: Der Anaesthesist
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