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https://www.readbyqxmd.com/read/29166719/-clinical-characteristics-and-outcome-comparison-between-atrial-fibrillation-patients-underwent-catheter-ablation-under-general-aesthesia-or-local-anesthesia-and-sedation
#1
J J Xu, L J Gao, D Chang, X J Xiao, R F Zhang, J Lin, Z M Zhao, H Zhang, Y L Xia, X M Yin, Y Z Yang
Objective: To compare the outcome of radiofrequency catheter ablation under local anesthesia/sedation (S) or general anesthesia(GA) in atrial fibrillation patients. Methods: Data of 498 patients with atrial fibrillation undergoing radiofrequency catheter ablation in our departmentfrom January 2014 to December 2015 were retrospectively analyzed. Two hundred and twenty patients assigned to the GA group, the other 278 patients to the S group. Patients were followed clinically every 3 months within one year after procedure...
November 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29166690/-facial-emotion-recognition-theory-of-mind-and-empathy-in-multiple-sclerosis
#2
Samar S Ayache, Moussa A Chalah, Tania Kuempfel, Frank Padberg, Jean-Pascal Lefaucheur, Ulrich Palm
Multiple sclerosis (MS), a chronic progressive inflammatory disease of the central nervous system, causes frequent disability, mood disorders, fatigue, and cognitive dysfunction. As a part of the last, social cognition is frequently disturbed in MS patients. It comprises empathy and social perception of emotions from facial, bodily and vocal cues. Social cognitive deficits worsen affect decoding, interpersonal relationship, and quality of life. Despite the impact of these deficits on global functioning, only a small number of studies have investigated its correlations and overlaps with MS symptoms...
November 2017: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/29166668/interleukin-36%C3%AE-and-il-36-receptor-signaling-mediate-impaired-host-immunity-and-lung-injury-in-cytotoxic-pseudomonas-aeruginosa-pulmonary-infection-role-of-prostaglandin-e2
#3
Tetsuji Aoyagi, Michael W Newstead, Xianying Zeng, Yuta Nanjo, Marc Peters-Golden, Mitsuo Kaku, Theodore J Standiford
Pseudomonas aeruginosa is a Gram-negative pathogen that can lead to severe infection associated with lung injury and high mortality. The interleukin (IL)-36 cytokines (IL-36α, IL-36β and IL-36γ) are newly described IL-1 like family cytokines that promote inflammatory response via binding to the IL-36 receptor (IL-36R). Here we investigated the functional role of IL-36 cytokines in the modulating of innate immune response against P. aeruginosa pulmonary infection. The intratracheal administration of flagellated cytotoxic P...
November 22, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29166650/feeding-induced-changes-in-allatostatin-a-and-short-neuropeptide-f-in-the-antennal-lobes-affect-odor-mediated-host-seeking-in-the-yellow-fever-mosquito-aedes-aegypti
#4
Peter Christ, Anna Reifenrath, Jörg Kahnt, Frank Hauser, Sharon Rose Hill, Joachim Schachtner, Rickard Ignell
Aedes aegypti is a model species in which the endogenous regulation of odor-mediated host seeking behavior has received some attention. Sugar feeding and host seeking in female A. aegypti are transiently inhibited following a blood meal. This inhibition is partially mediated by short neuropeptide F (sNPF). The paired antennal lobes (ALs), as the first processing centers for olfactory information, has been shown to play a significant role in the neuropeptidergic regulation of odor-mediated behaviors in insects...
2017: PloS One
https://www.readbyqxmd.com/read/29166645/angiotensin-ii-infusion-does-not-cause-abdominal-aortic-aneurysms-in-apolipoprotein-e-deficient-rats
#5
Evan H Phillips, Mandy S Chang, Sydney Gorman, Hamna J Qureshi, Karin F K Ejendal, Tamara L Kinzer-Ursem, A Nicole Blaize, Craig J Goergen
The apolipoprotein E-deficient (apoE-/-) mouse model has advanced our understanding of cardiovascular disease mechanisms and experimental therapeutics. This spontaneous model recapitulates aspects of human atherosclerosis, and allows for the development of dissecting abdominal aortic aneurysms (AAAs) when combined with angiotensin II. We characterized apoE-/- rats and hypothesized that, similar to mice, they would develop dissecting AAAs. We created rats with a 16-bp deletion of the apoE gene using transcription activator-like effector nucleases...
November 23, 2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/29166608/s-nitrosylation-of-pink1-attenuates-pink1-parkin-dependent-mitophagy-in-hipsc-based-parkinson-s-disease-models
#6
Chang-Ki Oh, Abdullah Sultan, Joseph Platzer, Nima Dolatabadi, Frank Soldner, Daniel B McClatchy, Jolene K Diedrich, John R Yates, Rajesh Ambasudhan, Tomohiro Nakamura, Rudolf Jaenisch, Stuart A Lipton
Mutations in PARK6 (PINK1) and PARK2 (Parkin) are linked to rare familial cases of Parkinson's disease (PD). Mutations in these genes result in pathological dysregulation of mitophagy, contributing to neurodegeneration. Here, we report that environmental factors causing a specific posttranslational modification on PINK1 can mimic these genetic mutations. We describe a molecular mechanism for impairment of mitophagy via formation of S-nitrosylated PINK1 (SNO-PINK1). Mitochondrial insults simulating age- or environmental-related stress lead to increased SNO-PINK1, inhibiting its kinase activity...
November 21, 2017: Cell Reports
https://www.readbyqxmd.com/read/29166577/cell-cycle-related-kinase-regulates-mammalian-eye-development-through-positive-and-negative-regulation-of-the-hedgehog-pathway
#7
Floria I Lupu, Jacob B Burnett, Jonathan T Eggenschwiler
Cell cycle-related kinase (CCRK) is a conserved regulator of ciliogenesis whose loss in mice leads to a wide range of developmental defects, including exencephaly, preaxial polydactyly, skeletal abnormalities, and microphthalmia. Here, we investigate the role of CCRK in mouse eye development. Ccrk mutants show dramatic patterning defects, with an expansion of the optic stalk domain into the optic cup, as well as an expansion of the retinal pigment epithelium (RPE) into neural retina (NR) territory. In addition, Ccrk mutants display a shortened optic stalk...
November 19, 2017: Developmental Biology
https://www.readbyqxmd.com/read/29166117/adsorption-and-conformations-of-lysozyme-and-%C3%AE-lactalbumin-at-a-water-octane-interface
#8
David L Cheung
As proteins contain both hydrophobic and hydrophilic amino acids, they will readily adsorb onto interfaces between water and hydrophobic fluids such as oil. This adsorption normally causes changes in the protein structure, which can result in loss of protein function and irreversible adsorption, leading to the formation of protein interfacial films. While this can be advantageous in some applications (e.g., food technology), in most cases it limits our ability to exploit protein functionality at interfaces...
November 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29166032/combined-cononsolvency-and-temperature-effects-on-adsorbed-pnipam-microgels
#9
Sebastian Backes, Patrick Krause, Weronika Tabaka, Marcus U Witt, Regine von Klitzing
The present study adresses the multi-responsive behavior of Poly(N-isopropylacrylamide) (PNIPAM) microgels adsorbed to interfaces. The microgels react to changes in temperature by shrinking in aqueous solution above their volume phase transition temperature (VPTT). Additionally, they shrink in mixtures of water and ethanol, although both individual liquids are good solvents for PNIPAM. The combination of this so-called cononsolvency effect and the temperature response of adsorbed microgels is studied by atomic force microscopy (AFM)...
November 22, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29165769/current-views-of-chromosomal-abnormalities-in-pediatric-acute-myeloid-leukemia-aml
#10
L-H Shi, P Ma, J-S Liu, Y Li, Y-F Wang, M-F Guo, W Liu
Chromosomal abnormalities are an attractive avenue for the screening of various disorders especially related to carcinogens like acute myeloid leukemia (AML). The cytogenetic findings like Karyotypic patterns are common in pediatric patients. On the other hand, monosomal karyotype (MK) and complex karyotype (CK) are more common in older patients. Further, recent studies have revealed direct proportion between the number of chromosome abnormalities and mortality rates in both pediatric as well as old patients affected by AML...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29165654/infusions-of-nerve-growth-factor-into-the-developing-frontal-cortex-leads-to-deficits-in-behavioral-flexibility-and-increased-perseverance
#11
Sagar J Desai, Brian L Allman, Nagalingam Rajakumar
In the pursuit of further establishing a neurodevelopmental animal model to investigate the mechanisms underlying impaired executive function, a core and severely debilitating symptom of schizophrenia, we sought to characterize the deficits in behavioral flexibility in adult rats following neonatal infusions of nerve growth factor (NGF) into the medial part of the developing frontal cortex. Our previous studies using this neonatal frontal cortical lesion model have shown that it leads to adult-onset positive and negative symptom-like features, and several neuropathological abnormalities of schizophrenia...
November 17, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29165653/transgenerational-effects-of-bisphenol-a-on-gene-expression-and-dna-methylation-of-imprinted-genes-in-brain
#12
Zuzana Drobná, Anne D Henriksen, Jennifer T Wolstenholme, Catalina Montiel, Philip S Lambeth, Stephen Shang, Erin P Harris, Changqing Zhou, Jodi A Flaws, Mazhar Adli, Emilie F Rissman
Bisphenol A (BPA) is a ubiquitous man-made endocrine disrupting compound (EDC). Developmental exposure to BPA changes behavioral and reproductive phenotypes and these effects can last for generations. We exposed embryos to BPA producing two lineages: controls and BPA-exposed. In the third generation (F3), brain tissues containing the preoptic area, the bed nucleus of the stria terminalis, and the anterior hypothalamus were collected. RNA sequencing (RNA-Seq) and subsequent data analyses revealed 50 differentially regulated genes in the brains of F3 juveniles from BPA- versus control-lineages...
November 17, 2017: Endocrinology
https://www.readbyqxmd.com/read/29165603/all-roads-lead-to-the-vacuole-autophagic-transport-as-part-of-the-endomembrane-trafficking-network-in-plants
#13
Kamila Kalinowska, Erika Isono
Plants regulate their development and response to the changing environment by sensing and interpreting environmental signals. Intracellular trafficking pathways including endocytic-, vacuolar-, and autophagic trafficking are important for the various aspects of responses in plants. Studies in the last decade have shown that the autophagic transport pathway uses common key components of endomembrane trafficking as well as specific regulators. A number of factors previously described for their function in endosomal trafficking have been discovered to be involved in the regulation of autophagy in plants...
November 19, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29165466/the-lone-pair-electron-driven-phase-transition-and-order-disorder-processes-in-thermochromic-2-mim-sbi4-organic-inorganic-hybrid
#14
A Gągor, G Banach, M Węcławik, A Piecha-Bisiorek, R Jakubas
The easy to prepare and stable in air (2-methylimidazolium) tetraiodoantimoniate(iii) single-crystals with optical band gap of 2.17(1) eV at room temperature have been synthesized. The crystal structure features one-dimensional [SbI4](-)n anionic chains, which are intercepted with stacks of 2MIm(+) ions. At 294/295 K, it undergoes a structural phase transition to an incommensurately modulated phase as a result of subtle, lone-pair-electron-driven distortions of the anions. Separately from the anion displacements, the ordering of 2MIm(+) countercations takes place over a wide temperature range of the modulated phase...
November 22, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29165412/-stabilizing-effectiveness-of-orthokeratology-and-long-term-minute-concentration-atropine-therapy-in-myopia-draft-report
#15
T Yu Verzhanskaya, E P Tarutta
The rational for the study was the high prevalence of myopia in the world. According to the World Health Organization (WHO), myopia is one of the five leading causes of blindness and low vision. Of recent reports on conservative measures for the stabilization of myopia, two areas of investigation deserve attention: methods of optical correction that affect peripheral refraction, orthokeratology lenses (OKL) in particular, and pharmacotherapy. The aim of the study was to evaluate the effectiveness and safety of myopia control in pediatric patients by combining two methods - OKL wearing and instillation of extra low doses of atropine (0...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/29165390/comparison-of-anionic-cationic-and-nonionic-surfactants-as-dispersing-agents-for-graphene-based-on-the-fluorescence-of-riboflavin
#16
Rocío Mateos, Soledad Vera, Mercedes Valiente, Ana María Díez-Pascual, María Paz San Andrés
Fluorescence quenching is a valuable tool to gain insight about dynamic changes of fluorophores in complex systems. Graphene (G), a single-layered 2D nanomaterial with unique properties, was dispersed in surfactant aqueous solutions of different nature: non-ionic polyoxyethylene-23-lauryl ether (Brij L23), anionic sodium dodecylsulphate (SDS), and cationic hexadecyltrimethylammonium bromide (CTAB) and dodecyltrimethylammonium bromide (DTAB). The influence of the surfactant type, chain length and concentration, G total concentration and G/surfactant weight ratio on the fluorescence intensity of vitamin B₂ (riboflavin) was investigated...
November 22, 2017: Nanomaterials
https://www.readbyqxmd.com/read/29165360/dynamic-docking-a-paradigm-shift-in-computational-drug-discovery
#17
REVIEW
Dario Gioia, Martina Bertazzo, Maurizio Recanatini, Matteo Masetti, Andrea Cavalli
Molecular docking is the methodology of choice for studying in silico protein-ligand binding and for prioritizing compounds to discover new lead candidates. Traditional docking simulations suffer from major limitations, mostly related to the static or semi-flexible treatment of ligands and targets. They also neglect solvation and entropic effects, which strongly limits their predictive power. During the last decade, methods based on full atomistic molecular dynamics (MD) have emerged as a valid alternative for simulating macromolecular complexes...
November 22, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29164891/unexpected-solubility-enhancement-of-drug-bases-in-presence-of-a-dimethylaminoethyl-methacrylate-copolymer
#18
Wiebke Saal, Alfred Ross, Nicole Wyttenbach, Jochem Alsenz, Martin Kuentz
The methacrylate-copolymer Eudragit® EPO (EPO) has previously shown to greatly enhance solubilization of acidic drugs via ionic interactions and by multiple hydrophobic contacts with polymeric side chains. The latter type of interaction could also play a role for solubilization of other compounds than acids. The aim of this study was therefore to investigate the solubility of six poorly soluble bases in presence and absence of EPO by quantitative ultra-pressure liquid chromatography with concomitant X-ray powder diffraction (XRPD) analysis of the solid state...
November 22, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29164869/role-of-secondary-particle-formation-in-the-persistence-of-silver-nanoparticles-in-humic-acid-containing-water-under-light-irradiation
#19
Tuoya Zhang, Dawei Lu, Lixi Zeng, Yongguang Yin, Yujian He, Qian Liu, Guibin Jiang
The wide use of silver nanoparticles (AgNPs) leads to the increasing release of AgNPs into the environment. Dissolved organic matter (DOM) is a key factor affecting the behaviors and fate of AgNPs in the aquatic environment. However, the mechanisms for the DOM-mediated transformations of AgNPs are still not fully understood. In this study, we investigated the persistence of AgNPs in aquatic environment in the presence of different concentrations of humic acid (HA) over periods of time up to 14 days. The Ag species were monitored and characterized by absorption spectrometry, transmission electron microscopy (TEM), inductively coupled plasma mass spectrometry (ICP-MS), and multicollector ICP-MS (MC-ICP-MS)...
November 22, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29164850/exploring-highly-reversible-1-5-electron-reactions-v3-v4-v5-in-na3vcr-po4-3-cathode-for-sodium-ion-batteries
#20
Rui Liu, Guiliang Xu, Qi Li, Shiyao Zheng, Guorui Zheng, Zhengliang Gong, Yixiao Li, Elizaveta Kruskop, Riqiang Fu, Zonghai Chen, Khalil Amine, Yong Yang
Development of highly reversible multi-electron reaction per redox center in NASICON-structured cathode materials is desired to improve the energy density of Sodium-ion batteries. Here, we investigated more than one electron storage of Na in Na3VCr(PO4)3. Combining a series of advanced characterization techniques such as ex situ 51V solid-state nuclear magnetic resonance, X-ray absorption near edge structure and in situ X-ray diffraction, we reveal that, V3+/V4+ and V4+/V5+ redox couples in the materials can be accessed, leading to 1...
November 22, 2017: ACS Applied Materials & Interfaces
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