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https://www.readbyqxmd.com/read/28238722/hormetic-modulation-of-hepatic-insulin-sensitivity-by-advanced-glycation-end-products
#1
Nelly T Fabre, Karina Thieme, Karolline S Silva, Sérgio Catanozi, Ana Mercedes Cavaleiro, Danilo A C Pinto, Maristela M Okamoto, Mychel Raony P T Morais, Bárbara Falquetto, Telma M Zorn, Ubiratan F Machado, Marisa Passarelli, Maria Lúcia Correa-Giannella
Because of the paucity of information regarding metabolic effects of advanced glycation end products (AGEs) on liver, we evaluated effects of AGEs chronic administration in (1) insulin sensitivity; (2) hepatic expression of genes involved in AGEs, glucose and fat metabolism, oxidative stress and inflammation and; (3) hepatic morphology and glycogen content. Rats received intraperitoneally albumin modified (AlbAGE) or not by advanced glycation for 12 weeks. AlbAGE induced whole-body insulin resistance concomitantly with increased hepatic insulin sensitivity, evidenced by activation of AKT, inactivation of GSK3, increased hepatic glycogen content, and decreased expression of gluconeogenesis genes...
February 23, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28163113/the-estimation-of-the-traditionally-used-yarrow-achillea-millefolium-l-asteraceae-oil-extracts-with-anti-inflamatory-potential-in-topical-application
#2
Vanja Tadić, Ivana Arsić, Jelena Zvezdanović, Ana Zugić, Dragan Cvetković, Sava Pavkov
ETHNOPHARMACOLOGICAL RELEVANCE: Olive or sunflower oil yarrow extracts have been extensively used against inflammatory disorders and skin wound healing in traditional medicine. AIM OF THE STUDY: To evaluate oil yarrow extracts traditional use in treatment of topical/dermatological skin impairments, sodium lauryl sulfate test was applied, and in vivo measuring of the biophysical parameters (erythema index, skin capacitance and the pH of the skin) in the artificially irritated skin was performed...
February 2, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28107918/bismuth-nanoparticles-carbon-nanotubes-modified-sensor-for-sulfasalazine-analysis
#3
Biljana Nigović, Sandra Jurić, Iva Mitrović
Nanocomposite of bismuth nanoparticles and carbon nanotubes in Nafion matrix was used as modifier for glassy carbon electrode in analysis of anti-inflamatory drug sulfasalazine. The nanocomposite surface exhibited exceptional synergy and remarkable enhancement effect to the voltammetric response of drug. The surface morphology and structure characterization of the modified electrodes was characterized by scanning electron microscopy, energy dispersive X-ray spectroscopy and cyclic voltammetry. The sensor exhibited excellent electroanalytical performance for drug determination in comparison with bismuth film electrode...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/27977311/flurbiprofen-loaded-niosomes-in-gel-system-improves-the-ocular-bioavailability-of-flurbiprofen-in-the-aqueous-humor
#4
Marwa M El-Sayed, Amal K Hussein, Hatem A Sarhan, Heba F Mansour
The present work aimed to prolong the contact time of flurbiprofen (FBP) in the ocular tissue to improve the drug anti-inflammatory activity. Different niosome systems were fabricated adopting thin-film hydration technique and using the nonionic surfactant Span 60. The morphology of the prepared niosomes was characterized by scanning electron microscopy (SEM). Physical characterization by differential scanning calorimetry, X-ray powder diffraction and Fourier transform infrared spectroscopy were conducted for the optimized formula (F5) that was selected on the basis of percent entrapment efficiency, vesicular size and total lipid content...
January 31, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/27914256/the-effect-of-sambucus-nigra-l-extract-and-phytosinthesized-gold-nanoparticles-on-diabetic-rats
#5
Razvan Opris, Corina Tatomir, Diana Olteanu, Remus Moldovan, Bianca Moldovan, Luminita David, Andras Nagy, Nicoleta Decea, Mihai Ludovic Kiss, Gabriela Adriana Filip
Nanomaterials such as gold nanoparticles (NPs) conjugated with natural products have shown good results in lowering the glycated hemoglobin and have an anti-inflamatory effect. The aim of our study is to evaluate the antidiabetic effect of NPs functionalized with Sambucus nigra L. (SN) extract on experimental model of diabetes in rats. Diabetes was induced to 18 Wistar male rats (n=6) by a single intramuscular injection of streptozotocin (30mg/kg body weight - b.w.). SN extract (15mg/kg b.w.), NPs (0.3mg/kg b...
February 1, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27790461/in-vivo-and-in-vitro-anti-inflammatory-activity-of-indazole-and-its-derivatives
#6
Chakrapani Cheekavolu, M Muniappan
INTRODUCTION: The inflammatory response is closely intertwined with the process of repair. However in some diseases the inflammatory response may be exaggerated and sustained without apparent benefit and even with severe adverse complications. For decades, we have been primarily relying upon Nonsteroidal (NSAID) and Steroidal Anti-Inflammatory agents for management of various inflammatory conditions. However, adverse effects of these drugs are severe which often leads to patient's non-compliance with inadequate relief...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27775307/-balanitis-xerotica-obliterans-underdiagnosed-pathology-of-clinical-relevance
#7
E Calleja Aguayo, A E Hernández Calvarro, C Marhuenda Irastorza
OBJECTIVES: Balanitis xerotica obliterans (BXO) is a chronic inflamatory disease, a genital form of Lichen Sclerosus in males. MATERIAL AND METHODS: This retrospective and descriptive analysis was carried out by rewiew of the medical records of boys who underwent circumcision from April 2013 to April 2014. The study group consisted of boys that were circumcised due it persistant phimosis at 4 years of age, urinary symptoms or painful erection. The histopathological examination was performed only in patients with clinical suspicion of BXO...
July 20, 2015: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
https://www.readbyqxmd.com/read/27579619/i%C3%AE%C2%BAb%C3%AE-an-emerging-player-in-cancer
#8
REVIEW
Marie Willems, Nadège Dubois, Lucia Musumeci, Vincent Bours, Pierre A Robe
IκBζ, an atypical member of the nuclear IκB family of proteins, is expressed at low levels in most resting cells, but is induced upon stimulation of Toll-like/IL-1 receptors through an IRAK1/IRAK4/NFκB-dependent pathway. Like its homolog Bcl3, IκBζ can regulate the transcription of a set of inflamatory genes through its association with the p50 or p52 subunits of NF-κB. Long studied as a key component of the immune response, IκBζ emerges as an important regulator of inflammation, cell proliferation and survival...
October 4, 2016: Oncotarget
https://www.readbyqxmd.com/read/27507606/the-correlation-of-increased-crp-levels-with-nfkb1-and-tlr2-polymorphisms-in-the-case-of-morbid-obesity
#9
T Soydas, O Karaman, H Arkan, G Yenmis, M M Ilhan, K Tombulturk, E Tasan, G Kanigur Sultuybek
Morbid obesity (MO) is associated with an increase in circulating levels of systemic acute phase proteins such as C-reactive protein (CRP). Toll-like receptor is possible candidate for inflammatory responses which is mainly mediated by NFKB1. The aim of this study was to investigate the relationship between NFKB1 and Toll-like receptor (TLR) 2 polymorphisms and the risk of MO in a Turkish population in the context of CRP serum levels which may contribute to susceptibility to the disease. We analysed the distribution of NFKB1-94 ins/del ATTG rs28362491 and TLR2 Arg753Gln rs5743708 polymorphisms using PCR-RFLP method and CRP serum levels using ELISA method in 213 MO and 200 healthy controls...
November 2016: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/27426510/the-anti-tumor-effect-and-bioactive-phytochemicals-of-hedyotis-diffusa-willd-on-ovarian-cancer-cells
#10
Lin Zhang, Jing Zhang, Bing Qi, Guoqiang Jiang, Jia Liu, Pei Zhang, Yuan Ma, Weiling Li
ETHNOPHARMACOLOGICAL RELEVANCE: Hedyotis diffusa willd (HDW) is a widely used medicinal herb in China. It processed various medicinal properties including antioxidative, anti-inflamatory and anti-cancer effects. This study aimed to investigate the anti-tumor effects of HDW on ovarian cancer cells and the underlying mechanisms as well as identify the bioactive compounds. MATERIALS AND METHODS: Effects of HDW on the viability of ovarian cancer A2780 cells were detected by MTT assay...
November 4, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27422212/-pharmaceutical-intervention-to-reduce-the-iatrogenic-risk-associated-with-the-triple-whammy-combination
#11
Gemma Arrufat-Goterris, Fernando do Pazo-Oubiña, María Malpartida-Flores, Raquel María Rodríguez-Rincón
OBJECTIVE: To analyze the effect of an intervention to reduce the iatrogenic risk associated with concomitant treatment with angiotensin converting enzyme inhibitors (ACEi) and/or angiotensin-II receptor blockers (ARB) with diuretics and nonsteroidal anti-inflamatory drugs (NSAID), combination known as triple whammy (TW). DESIGN: Uncontrolled before-after intervention study. LOCATION: 15 health centers from a health area (reference population of 292...
July 12, 2016: Atencion Primaria
https://www.readbyqxmd.com/read/27291692/protective-effects-of-vitamin-d3-against-d-galactosamine-induced-liver-injury-in-rats
#12
Neriman Colakoglu, Tuncay Kuloglu, Enver Ozan, Nevin Kocaman, Durrin Ozlem Dabak, Gozde Parlak
In this study, we examined liver damage induced by d-galactosamine (d-GaIN) and the protective effects of vitamin D3 in relation to d-GaIN toxicity. Twenty Wistar albino rats were used in this study. The rats were divided into four groups. Group I rats were used as the control group. Group II rats were given a single intraperitoneal injection of d-GaIN. Group III rats were given a single intraperitoneal injection of d-GaIN, intramuscular vitamin D3 for five days. Group IV rats were given intramuscular vitamin D3 for five days...
August 2016: Tissue & Cell
https://www.readbyqxmd.com/read/27002758/inflammatory-myofibroblastic-duodenal-tumor-a-rare-cause-of-massive-intestinal-bleeding
#13
Miriam García González, Diego Vela, Mónica Álvarez, Jesús Caramés
BACKGROUND: Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal tumor, which can develop in nearly all anatomical locations. It is extremely rare in the duodenum and only seven cases have been reported previously.These lesions are of unknown etiology characterized by proliferation of myofibroblastic with an inflammatory infiltrate. It is considered a tumor of borderline malignancy. OBJECTIVE: We report the first case described of IMT located isolated in the third duodenal portion, which develops as a massive intestinal bleeding in a 14 years old girl...
March 11, 2016: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/26978883/clinical-impact-in-the-management-of-neovascular-glaucoma
#14
MULTICENTER STUDY
Halil Ajvazi, Pajtim Lutaj
INTRODUCTION: Neovascular glaucoma (NVG), participates in the group of secondary glaucoma causing the-increase of intraocular pressure (IOP) as a result of iridocorneal angle enclosure with the development of neovase derived from the retinal ischemic and other inflamatory diseases. PURPOSE OF THE STUDY: Is to show the incidence, etiopathogenesis, clinical development and the management of NVG by comparing the contemporary and referring literature to other clinics...
July 2015: Romanian Journal of Ophthalmology
https://www.readbyqxmd.com/read/26663823/oxidative-stress-and-inflamatory-plasma-biomarkers-in-respiratory-syncytial-virus-bronchiolitis
#15
Gloria Moreno-Solís, María Jose de la Torre-Aguilar, Javier Torres-Borrego, Francisco Javier Llorente-Cantarero, Fernando Fernández-Gutiérrez, Mercedes Gil-Campos, Isaac Túnez-Fiñana, Juan Luis Pérez-Navero
INTRODUCTION: Oxidative stress (OS) plays a crucial role in the pathogenesis of inflammatory lung diseases. OBJECTIVES: (1) We determined whether acute bronchiolitis (AB) caused by respiratory syncytial virus (RSV) induced OS; (2) assessed whether OS biomarkers correlated with the severity of RSV-AB; and (3) studied whether the levels of interleukins are associated with OS biomarkers. METHODS: We performed an observational study by comparing healthy infants (Group 1) with RSV-AB infants, classified as Group 2 (pulse oximetry (SpO2 ) >93%), and Group 3 (SpO2  ≤ 92%), which needed oxygen therapy...
December 9, 2015: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/26562779/cytotoxic-and-apoptotic-effects-of-leptocarpin-a-plant-derived-sesquiterpene-lactone-on-human-cancer-cell-lines
#16
Claudia Bosio, Giacomo Tomasoni, Rolando Martínez, Andrés F Olea, Héctor Carrasco, Joan Villena
Sesquiterpene lactones have attracted much attention in drug research because they present a series of biological activities such as anticancer, antifungal, anti-inflammatory, antimicrobial and antioxidant. Leptocarpin (LTC) is a sesquiterpene lactone isolated from a native Chilean plant, Leptocarpha rivularis, which has been widely used in traditional medicine by Mapuche people. Previous work has demonstrated that LTC decreases cell viability of cancer cell lines. In this contribution, we analyze the mechanism of LTC cytotoxicity on different cancer cell lines...
December 5, 2015: Chemico-biological Interactions
https://www.readbyqxmd.com/read/26533501/costs-of-inflamatory-bowel-disease-crohns-disease-and-ulcerative-colitis-in-serbia
#17
M Kostic, L Djakovic, R Sujic, S Jankovic
No abstract text is available yet for this article.
November 2015: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/26522689/neuroprotection-of-neuro2a-cells-and-the-cytokine-suppressive-and-anti-inflammatory-mode-of-action-of-resveratrol-in-activated-raw264-7-macrophages-and-c8-b4-microglia
#18
Nicole Steiner, Rachelle Balez, Niloo Karunaweera, Joanne M Lind, Gerald Münch, Lezanne Ooi
Chronic inflammation is a hallmark of neurodegenerative disease and cytotoxic levels of nitric oxide (NO) and pro-inflammatory cytokines can initiate neuronal death pathways. A range of cellular assays were used to assess the anti-inflammatory and neuroprotective action of resveratrol using murine microglial (C8-B4), macrophage (RAW264.7) and neuronal-like (Neuro2a) cell lines. We examined the release of NO by Griess assay and used a Bioplex array to measure a panel of pro- and anti-inflammatory cytokines and chemokines, in response to the inflammatory stimuli lipopolysaccharide (LPS) and interferon-γ (IFN-γ)...
May 2016: Neurochemistry International
https://www.readbyqxmd.com/read/26521998/radioisotope-synoviorthesis-in-paediatric-and-adolescent-patients-with-haemophilia
#19
A Martínez-Esteve, R M Álvarez-Pérez, R Núñez-Vázquez, J L Tirado-Hospital, R García-Jiménez, J Povedano-Gómez, I Borrego-Dorado
OBJECTIVE: To assess the outcome and adverse-effects of the radioisotope synoviorthesis in paediatric and adolescent patients with haemophilia. MATERIAL AND METHODS: Prospective study of historical cohort was conducted. A total of 20 consecutive haemophiliacs with a mean age of 13.1 years (range 4-17) were included with a mean follow-up of 64.9 months (range 18-109). The diagnosis of synovitis was established on the basis of clinical follow-up including radiological images (radiography and/or MRI)...
January 2016: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/26488744/soluble-cd40-ligand-in-sera-of-subjects-exposed-to-leishmania-infantum-infection-reduces-the-parasite-load-in-macrophages
#20
Fabrícia Alvisi de Oliveira, Aline Silva Barreto, Lays G S Bomfim, Talita Rebeca S Leite, Priscila Lima Dos Santos, Roque Pacheco de Almeida, Ângela Maria da Silva, Malcolm S Duthie, Steven G Reed, Tatiana Rodrigues de Moura, Amélia Ribeiro de Jesus
BACKGROUND: While CD40L is typically a membrane glycoprotein expressed on activated T cells and platelets that binds and activates CD40 on the surface on antigen presenting cells, a soluble derivative (sCD40L) that appears to retain its biological activity after cleavage from cell membrane also exists. We recently reported that sCD40L is associated with clinical resolution of visceral leishmaniasis and protection against the disease. In the present study we investigated if this sCD40L is functional and exerts anti-parasitic effect in L...
2015: PloS One
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