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https://www.readbyqxmd.com/read/29756563/cyclooxygenase-2-inhibitors-as-a-therapeutic-target-in-inflammatory-diseases
#1
Miguel D Ferrer, Carla Busquests-Cortes, Xavier Capo, Silvia Tejada, Josep A Tur, Antoni Pons, Antoni Sureda
Inflammation plays a crucial role in the development of many complex diseases and disorders including autoimmune diseases, metabolic syndrome, neurodegenerative diseases, and cardiovascular pathologies. Prostaglandins play a regulatory role in inflammation. Cyclooxygenases are the main mediators of inflammation by catalyzing the initial step of arachidonic acid metabolism and prostaglandin synthesis. The differential expression of the constitutive isoform COX-1 and the inducible isoform COX-2, and the finding that COX-1 is the major form expressed in the gastro-intestinal tract, lead to the search for COX-2-selective inhibitors as anti-inflammatory agents that might diminish the gastrointestinal side effects of traditional non-steroidal anti-inflamatory drugs (NSAIDs)...
May 13, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29736096/potential-anti-inflammatory-treatment-of-ischemic-heart-disease
#2
Enisa Hodzic
Introduction: Ischemic heart disease (IHD) is clinical manifestation of chronic inflammatory progressive pathological process of atherosclerosis in coronary arteries. IHD is the leading cause of morbidity and mortality in the world. The question is whether it is possible to improve and direct the therapeutic treatment of IHD patients in the treatment of the inflammatory process in the atherosclerotic leasions. Material and Methods: A prospective, comparative, analytica,clinically applicable, open-type study was performed...
April 2018: Medical Archives
https://www.readbyqxmd.com/read/29664511/bullous-henoch-sch%C3%A3-nlein-purpura-case-report
#3
Trinidad Hasbún, Ximena Chaparro, Viera Kaplan, Felipe Cavagnaro, Alex Castro
Henoch-Schönlein purpura (HSP) or IgA Vasculitis is the most common childhood vasculitis. The classic tetrad of signs and symptoms include palpable purpura, arthralgia, abdominal pain and renal disease. The occurrence of hemorrhagic bullae in children with HSP is rarely encountered. Objec tive: To report an unusual cutaneous manifestation of HSP in children. CASE REPORT: A 14-year-old girl complained about a 2-week painful bullous rash in both lower extremities and multiple arthral gias...
February 2018: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/29660809/prosopis-nigra-mesocarp-fine-flour-a-source-of-phytochemicals-with-potential-effect-on-enzymes-linked-to-metabolic-syndrome-oxidative-stress-and-inflammatory-process
#4
María J Pérez, Iris C Zampini, Maria R Alberto, María I Isla
This work is part of the search in native food matrices from arid regions of Argentina of interest to improve human health. Prosopis species are ethnic food resources in South America capable of growing in arid and semi-arid environments. This work was focused to determine the nutritional and phytochemical composition of Prosopis nigra fine flour and to evaluate its biological properties. Flour showed a high level of sucrose (30.35 g/100 g flour), fiber (6.34 g/100 g flour), polyphenols (0.45 g GAE/100 g flour), and minerals (potassium, calcium, and magnesium)...
April 16, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29307123/the-role-of-diet-in-managing-inflamatory-bowel-disease-affected-dogs-a-retrospective-cohort-study-on-76-cases
#5
Maria Chiara Marchesi
The term in ammatory bowel diseases (IBD) refers to a group of idiopathic, chronic intestinal diseases characterized by a di use in ltration of in ammatory cells into the lamina propria of the intestine. The pathogenesis of IBD is unknown. The most common signs described are diarrhoea, vomit, and progressive weight loss. In order to make a de nitive diagnosis, though, the presence of in ammatory cells in ltration must be evident on histopathologic analysis. The therapeutic approach has 2 main goals: decrease the in ammatory response and remove possible antigenic sources, such as food components or intestinal micro ora...
December 29, 2017: Veterinaria Italiana
https://www.readbyqxmd.com/read/29262407/the-role-of-%C3%AE-adrenergic-overstimulation-in-the-early-stages-of-renal-injury
#6
Mariana Charleaux de Ponte, Fernando Augusto Malavazzi Casare, Juliana Martins Costa-Pessoa, Vanessa Gerolde Cardoso, Gerhard Malnic, Margarida Mello-Aires, Rildo Aparecido Volpini, Karina Thieme, Maria Oliveira-Souza
BACKGROUND/AIMS: To assess the possible contribution of the β-adrenergic overstimulation in early stages of renal injury, the present study evaluated, in rats, the effects of the β-adrenoceptor agonist isoproterenol (ISO) on renal function and morphology, as well as the renal mRNA and protein expression of the NADPH oxidase isoform 4 (Nox 4) and subunit p22phox, endoplasmic reticulum (ER) stress, pro-inflammatory, pro-apoptotic and renin-angiotensin system (RAS) components. METHODS: Wistar rats received ISO (0...
2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29194637/antioxidant-and-anti-inflammatory-activities-of-freeze-dried-grapefruit-phenolics-as-affected-by-gum-arabic-and-bamboo-fibre-addition-and-microwave-pretreatment
#7
Eva García-Martínez, Isabel Andújar, Alberto Yuste Del Carmen, Jaime Prohens, Nuria Martínez-Navarrete
BACKGROUND: Recent epidemiological studies have suggested that phenolic compounds present in grapefruit play an important role in the bioactive properties of this fruit. However, the consumption of fresh grapefruit is low. Freeze-dried powdered grapefruit can be an alternative to promote this fruit consumption. To improve the quality and stability of the powdered fruit, encapsulating and anticaking agents can be added. In the present study, different grapefruit powders obtained by freeze-drying with the addition of gum arabic (1...
December 1, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29190648/anterior-chamber-associated-immune-deviation-used-as-a-neuroprotective-strategy-in-rats-with-spinal-cord-injury
#8
Beatriz Pineda-Rodriguez, Diana Toscano-Tejeida, Elisa García-Vences, Roxana Rodriguez-Barrera, Adrian Flores-Romero, Daniela Castellanos-Canales, Gabriel Gutierrez-Ospina, Laura Castillo-Carvajal, Esperanza Meléndez-Herrera, Antonio Ibarra
The inflammatory response is probably one of the main destructive events occurring after spinal cord injury (SCI). Its progression depends mostly on the autoimmune response developed against neural constituents. Therefore, modulation or inhibition of this self-reactive reaction could help to reduce tissue destruction. Anterior chamber associated immune deviation (ACAID) is a phenomenon that induces immune-tolerance to antigens injected into the eye´s anterior chamber, provoking the reduction of such immune response...
2017: PloS One
https://www.readbyqxmd.com/read/29097487/long-term-protective-effect-of-n-acetylcysteine-against-amikacin-induced-ototoxicity-in-end-stage-renal-disease-a-randomized-trial
#9
Alperen Vural, İsmail Koçyiğit, Furkan Şan, Eray Eroğlu, İbrahim Ketenci, Aydin Ünal, Bülent Tokgöz, Yaşar Ünlü
BACKGROUND: The aim of the study is to evaluate the long-term protective effect of N-acetylcysteine (NAC), an antioxidant agent, against aminoglycoside (AG)-induced ototoxicity. METHODS: A total of 40 patients receiving continuous ambulatory peritoneal dialysis (CAPD) and having their first peritonitis attacks and planned to be treated with AGs were enrolled in the study. They were randomized into 2 groups: 1 group received additional NAC and the other did not. All patients underwent hearing tests with pure tone audiometry (PTA) after the diagnosis, at 1 month and 12 months and at the same time the tumor necrosis factor (TNF)-α and interleukin (IL)-6 levels were measured...
January 2018: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/28816983/characteristics-of-turkish-patients-with-elderly-onset-psoriatic-arthritis-a-retrospective-cohort-study
#10
Senol Kobak, Fidan Yildiz, Ahmet Karaarslan, Huseyin Semiz, Mehmet Orman
Psoriatic arthritis (PsA) is a chronic inflamatory disease characterized with axial and peripheral joints involvement. It rarely affects patients older than 65 years old.The purpose of this study is to compare and evaluate the demographic, clinical and laboratory features of elderly-onset psoriatic arthritis (EOPsA) and young-onset (YOPsA) patients.A total of 180 patients diagnosed with PsA according to CASPAR criteria and followed-up in single center were included in this study. The patients with initial symptoms started after age 65 were accepted as EOPsA...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28681913/targeting-p-glycoprotein-and-sorcin-dihydromyricetin-strengthens-anti-proliferative-efficiency-of-adriamycin-via-mapk-erk-and-ca-2-mediated-apoptosis-pathways-in-mcf-7-adr-and-k562-adr
#11
Yaoting Sun, Changyuan Wang, Qiang Meng, Zhihao Liu, Xiaokui Huo, Pengyuan Sun, Huijun Sun, Xiaodong Ma, Jinyong Peng, Kexin Liu
Recently, a new target Ca2+ -binding protein SORCIN was reported to participate in multidrug resistance (MDR) in cancer. Here we aim to investigate whether dihydromyricetin (DMY), a dihydroflavonol compound with anti-inflamatory, anti-oxidant, anti-bacterial and anti-tumor actions, reverses MDR in MCF-7/ADR and K562/ADR and to elucidate its potential molecular mechanism. DMY enhanced cytotoxicity of adriamycin (ADR) by downregulating MDR1 mRNA and P-gp expression through MAPK/ERK pathway and also inhibiting the function of P-gp significantly...
April 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28637418/anti-inflammatory-effect-of-crocus-sativus-on-serum-cytokine-levels-in-subjects-with-metabolic-syndrome-a-randomized-double-blind-placebo-controlled-trial
#12
Tayebe Kermani, Maedeh Zebarjadi, Hassan Mehrad-Majd, Seyed-Reza Mirhafez, Maryam Shemshian, Faezeh Ghasemi, Elham Mohammadzadeh, Seyed Hadi Mousavi, Abdolreza Norouzy, Toktam Moghiman, Akram Sadeghi, Gordon Ferns, Amir Avan, Elaheh Mahdipour, Majid Ghayour-Mobarhan
BACKGROUND/AIMS: A growing body of evidence supports an important role of inflammatory cytokines in the development and progression of the Metabolic Syndrome (MetS), which explains, at least in part, its relationship with an increased cardiovascular-risk. Several studies have reported the therapeutic-impact of crocus-sativus in a preclinical/clinical setting. Here we have explored the effects of crocus-sativus, on the serum concentrations of twelve serum cytokines in subjects with MetS in a randomized control trial...
2017: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/28628674/hepatic-microvascular-dysfunction-and-increased-advanced-glycation-end-products-are-components-of-non-alcoholic-fatty-liver-disease
#13
Evelyn Nunes Goulart da Silva Pereira, Raquel Rangel Silvares, Edgar Eduardo Ilaquita Flores, Karine Lino Rodrigues, Isalira Peroba Ramos, Igor José da Silva, Marcelo Pelajo Machado, Rosiane Aparecida Miranda, Carmen Cabanelas Pazos-Moura, Cassiano F Gonçalves-de-Albuquerque, Hugo Caire de Castro Faria-Neto, Eduardo Tibiriça, Anissa Daliry
BACKGROUND: This study aimed to investigate the pathophysiology of hepatic microcirculatory dysfunction in non-alcoholic fatty liver disease (NAFLD). METHODS: In Wistar rats, NAFLD model was induced by 20 weeks of high-fat diet (HFD) feeding. Rolling and adhesion of leukocytes and tissue perfusion in hepatic microcirculation were examined using in vivo microscopic and laser speckle contrast imaging (LSCI), respectively. Oxidative stress and inflamatory parameters were analysed by TBARs, catalase enzyme activity, RT-PCR and ELISA...
2017: PloS One
https://www.readbyqxmd.com/read/28571726/anti-tumor-effect-of-scutellaria-barbata-d-don-extracts-on-ovarian-cancer-and-its-phytochemicals-characterisation
#14
Lin Zhang, Baoyin Ren, Jing Zhang, Likun Liu, Jia Liu, Guoqiang Jiang, Man Li, Yuejia Ding, Weiling Li
ETHNOPHARMACOLOGICAL RELEVANCE: Scutellaria barbata D. Don is a widely used medicinal herb in China. It possess various medicinal properties including antioxidative, anti-inflammatory and anti-cancer effects. The aim of this study was to explore whether Scutellaria barbata D. Don could inhibit the growth of ovarian cancer cells in vitro and further investigate the underlying mechanisms. MATERIALS AND METHODS: Effects of Scutellaria barbata D. Don on the viability of ovarian cancer A2780 cells were measured by MTT assay...
July 12, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28556849/effects-of-age-on-systemic-inflamatory-response-syndrome-and-results-of-coronary-bypass-surgery
#15
Orhan Gokalp, Nihan Karakas Yesilkaya, Sahin Bozok, Yuksel Besir, Hasan Iner, Huseyin Durmaz, Yasar Gokkurt, Banu Lafci, Gamze Gokalp, Levent Yilik, Ali Gurbuz
BACKGROUND: Coronary artery bypass (CAB) surgery triggers systemic inflammatory response syndrome (SIRS) via several mechanisms. Moreover, age is directly correlated with SIRS. We evaluated the effect of age on SIRS and postoperative outcome after CAB surgery. METHODS: We retrospectively reviewed the records of 229 patients who had undergone CAB surgery. The patients were divided into three groups according to age: group 1, < 40 years (n = 61); group 2, 40-75 years (n = 83); and group 3, > 75 years old (n = 85)...
January 2018: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/28238722/hormetic-modulation-of-hepatic-insulin-sensitivity-by-advanced-glycation-end-products
#16
Nelly T Fabre, Karina Thieme, Karolline S Silva, Sérgio Catanozi, Ana Mercedes Cavaleiro, Danilo A C Pinto, Maristela M Okamoto, Mychel Raony P T Morais, Bárbara Falquetto, Telma M Zorn, Ubiratan F Machado, Marisa Passarelli, Maria Lúcia Correa-Giannella
Because of the paucity of information regarding metabolic effects of advanced glycation end products (AGEs) on liver, we evaluated effects of AGEs chronic administration in (1) insulin sensitivity; (2) hepatic expression of genes involved in AGEs, glucose and fat metabolism, oxidative stress and inflammation and; (3) hepatic morphology and glycogen content. Rats received intraperitoneally albumin modified (AlbAGE) or not by advanced glycation for 12 weeks. AlbAGE induced whole-body insulin resistance concomitantly with increased hepatic insulin sensitivity, evidenced by activation of AKT, inactivation of GSK3, increased hepatic glycogen content, and decreased expression of gluconeogenesis genes...
May 15, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28163113/the-estimation-of-the-traditionally-used-yarrow-achillea-millefolium-l-asteraceae-oil-extracts-with-anti-inflamatory-potential-in-topical-application
#17
RANDOMIZED CONTROLLED TRIAL
Vanja Tadić, Ivana Arsić, Jelena Zvezdanović, Ana Zugić, Dragan Cvetković, Sava Pavkov
ETHNOPHARMACOLOGICAL RELEVANCE: Olive or sunflower oil yarrow extracts have been extensively used against inflammatory disorders and skin wound healing in traditional medicine. AIM OF THE STUDY: To evaluate oil yarrow extracts traditional use in treatment of topical/dermatological skin impairments, sodium lauryl sulfate test was applied, and in vivo measuring of the biophysical parameters (erythema index, skin capacitance and the pH of the skin) in the artificially irritated skin was performed...
March 6, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28107918/bismuth-nanoparticles-carbon-nanotubes-modified-sensor-for-sulfasalazine-analysis
#18
Biljana Nigović, Sandra Jurić, Iva Mitrović
Nanocomposite of bismuth nanoparticles and carbon nanotubes in Nafion matrix was used as modifier for glassy carbon electrode in analysis of anti-inflamatory drug sulfasalazine. The nanocomposite surface exhibited exceptional synergy and remarkable enhancement effect to the voltammetric response of drug. The surface morphology and structure characterization of the modified electrodes was characterized by scanning electron microscopy, energy dispersive X-ray spectroscopy and cyclic voltammetry. The sensor exhibited excellent electroanalytical performance for drug determination in comparison with bismuth film electrode...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/27977311/flurbiprofen-loaded-niosomes-in-gel-system-improves-the-ocular-bioavailability-of-flurbiprofen-in-the-aqueous-humor
#19
Marwa M El-Sayed, Amal K Hussein, Hatem A Sarhan, Heba F Mansour
The present work aimed to prolong the contact time of flurbiprofen (FBP) in the ocular tissue to improve the drug anti-inflammatory activity. Different niosome systems were fabricated adopting thin-film hydration technique and using the nonionic surfactant Span 60. The morphology of the prepared niosomes was characterized by scanning electron microscopy (SEM). Physical characterization by differential scanning calorimetry, X-ray powder diffraction and Fourier transform infrared spectroscopy were conducted for the optimized formula (F5) that was selected on the basis of percent entrapment efficiency, vesicular size and total lipid content...
June 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/27914256/the-effect-of-sambucus-nigra-l-extract-and-phytosinthesized-gold-nanoparticles-on-diabetic-rats
#20
Razvan Opris, Corina Tatomir, Diana Olteanu, Remus Moldovan, Bianca Moldovan, Luminita David, Andras Nagy, Nicoleta Decea, Mihai Ludovic Kiss, Gabriela Adriana Filip
Nanomaterials such as gold nanoparticles (NPs) conjugated with natural products have shown good results in lowering the glycated hemoglobin and have an anti-inflamatory effect. The aim of our study is to evaluate the antidiabetic effect of NPs functionalized with Sambucus nigra L. (SN) extract on experimental model of diabetes in rats. Diabetes was induced to 18 Wistar male rats (n=6) by a single intramuscular injection of streptozotocin (30mg/kg body weight - b.w.). SN extract (15mg/kg b.w.), NPs (0.3mg/kg b...
February 1, 2017: Colloids and Surfaces. B, Biointerfaces
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