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E Calleja Aguayo, A E Hernández Calvarro, C Marhuenda Irastorza
OBJECTIVES: Balanitis xerotica obliterans (BXO) is a chronic inflamatory disease, a genital form of Lichen Sclerosus in males. MATERIAL AND METHODS: This retrospective and descriptive analysis was carried out by rewiew of the medical records of boys who underwent circumcision from April 2013 to April 2014. The study group consisted of boys that were circumcised due it persistant phimosis at 4 years of age, urinary symptoms or painful erection. The histopathological examination was performed only in patients with clinical suspicion of BXO...
April 20, 2016: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
Marie Willems, Nadège Dubois, Lucia Musumeci, Vincent Bours, Pierre A Robe
IκBζ, an atypical member of the nuclear IκB family of proteins, is expressed at low levels in most resting cells, but is induced upon stimulation of Toll-like/IL-1 receptors through an IRAK1/IRAK4/NFκB-dependent pathway. Like its homolog Bcl3, IκBζ can regulate the transcription of a set of inflamatory genes through its association with the p50 or p52 subunits of NF-κB. Long studied as a key component of the immune response, IκBζ emerges as an important regulator of inflammation, cell proliferation and survival...
August 26, 2016: Oncotarget
Tugba Soydas, Ozcan Karaman, Hulya Arkan, Guven Yenmis, M Muzaffer Ilhan, Kubra Tombulturk, Ertugrul Tasan, Gonul Kanigur Sultuybek
Morbid obesity(MO) is associated with an increase in circulating levels of systemic acute phase proteins such as C-reactive protein (CRP).Toll-like reseptor is possible candidate for inflamatory responses which is mainly mediated by NFKB. The aim of this study was to investigate the relationship between NFKB1 and TLR-2 polymorphisms and the risk of MO in a Turkish population in the context of CRP serum levels which may contribute to susceptibility to the disease. We analyzed the distribution of NFKB1 -94ins/delATTG rs28362491 and TLR-2 Arg753Gly rs5743708 polymorphisms using PCR-RFLP method and CRP serum levels using ELISA method in 213 MO and 200 healthy controls...
August 10, 2016: Scandinavian Journal of Immunology
Lin Zhang, Jing Zhang, Bing Qi, Guoqiang Jiang, Jia Liu, Pei Zhang, Yuan Ma, Weiling Li
ETHNOPHARMACOLOGICAL RELEVANCE: hedyotis diffusa willd (HDW) is a widely used medicinal herb in China. It processed various medicinal properties including antioxidative, anti-inflamatory and anti-cancer effects. This study aimed to investigate the anti-tumor effects of HDW on ovarian cancer cells and the underlying mechanisms as well as identify the bioactive compounds. MATERIALS AND METHODS: Effects of HDW on the viability of ovarian cancer A2780 cells were detected by MTT assay...
July 14, 2016: Journal of Ethnopharmacology
Gemma Arrufat-Goterris, Fernando do Pazo-Oubiña, María Malpartida-Flores, Raquel María Rodríguez-Rincón
OBJECTIVE: To analyze the effect of an intervention to reduce the iatrogenic risk associated with concomitant treatment with angiotensin converting enzyme inhibitors (ACEi) and/or angiotensin-II receptor blockers (ARB) with diuretics and nonsteroidal anti-inflamatory drugs (NSAID), combination known as triple whammy (TW). DESIGN: Uncontrolled before-after intervention study. LOCATION: 15 health centers from a health area (reference population of 292...
July 12, 2016: Atencion Primaria
Neriman Colakoglu, Tuncay Kuloglu, Enver Ozan, Nevin Kocaman, Durrin Ozlem Dabak, Gozde Parlak
In this study, we examined liver damage induced by d-galactosamine (d-GaIN) and the protective effects of vitamin D3 in relation to d-GaIN toxicity. Twenty Wistar albino rats were used in this study. The rats were divided into four groups. Group I rats were used as the control group. Group II rats were given a single intraperitoneal injection of d-GaIN. Group III rats were given a single intraperitoneal injection of d-GaIN, intramuscular vitamin D3 for five days. Group IV rats were given intramuscular vitamin D3 for five days...
August 2016: Tissue & Cell
Miriam García González, Diego Vela, Mónica Álvarez, Jesús Caramés
BACKGROUND: Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal tumor, which can develop in nearly all anatomical locations. It is extremely rare in the duodenum and only seven cases have been reported previously.These lesions are of unknown etiology characterized by proliferation of myofibroblastic with an inflammatory infiltrate. It is considered a tumor of borderline malignancy. OBJECTIVE: We report the first case described of IMT located isolated in the third duodenal portion, which develops as a massive intestinal bleeding in a 14 years old girl...
March 11, 2016: Cancer Biomarkers: Section A of Disease Markers
Halil Ajvazi, Pajtim Lutaj
INTRODUCTION: Neovascular glaucoma (NVG), participates in the group of secondary glaucoma causing the-increase of intraocular pressure (IOP) as a result of iridocorneal angle enclosure with the development of neovase derived from the retinal ischemic and other inflamatory diseases. PURPOSE OF THE STUDY: Is to show the incidence, etiopathogenesis, clinical development and the management of NVG by comparing the contemporary and referring literature to other clinics...
July 2015: Romanian Journal of Ophthalmology
Gloria Moreno-Solís, María Jose de la Torre-Aguilar, Javier Torres-Borrego, Francisco Javier Llorente-Cantarero, Fernando Fernández-Gutiérrez, Mercedes Gil-Campos, Isaac Túnez-Fiñana, Juan Luis Pérez-Navero
INTRODUCTION: Oxidative stress (OS) plays a crucial role in the pathogenesis of inflammatory lung diseases. OBJECTIVES: (1) We determined whether acute bronchiolitis (AB) caused by respiratory syncytial virus (RSV) induced OS; (2) assessed whether OS biomarkers correlated with the severity of RSV-AB; and (3) studied whether the levels of interleukins are associated with OS biomarkers. METHODS: We performed an observational study by comparing healthy infants (Group 1) with RSV-AB infants, classified as Group 2 (pulse oximetry (SpO2 ) >93%), and Group 3 (SpO2  ≤ 92%), which needed oxygen therapy...
December 9, 2015: Clinical Respiratory Journal
Claudia Bosio, Giacomo Tomasoni, Rolando Martínez, Andrés F Olea, Héctor Carrasco, Joan Villena
Sesquiterpene lactones have attracted much attention in drug research because they present a series of biological activities such as anticancer, antifungal, anti-inflammatory, antimicrobial and antioxidant. Leptocarpin (LTC) is a sesquiterpene lactone isolated from a native Chilean plant, Leptocarpha rivularis, which has been widely used in traditional medicine by Mapuche people. Previous work has demonstrated that LTC decreases cell viability of cancer cell lines. In this contribution, we analyze the mechanism of LTC cytotoxicity on different cancer cell lines...
December 5, 2015: Chemico-biological Interactions
M Kostic, L Djakovic, R Sujic, S Jankovic
No abstract text is available yet for this article.
November 2015: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Nicole Steiner, Rachelle Balez, Niloo Karunaweera, Joanne M Lind, Gerald Münch, Lezanne Ooi
Chronic inflammation is a hallmark of neurodegenerative disease and cytotoxic levels of nitric oxide (NO) and pro-inflammatory cytokines can initiate neuronal death pathways. A range of cellular assays were used to assess the anti-inflammatory and neuroprotective action of resveratrol using murine microglial (C8-B4), macrophage (RAW264.7) and neuronal-like (Neuro2a) cell lines. We examined the release of NO by Griess assay and used a Bioplex array to measure a panel of pro- and anti-inflammatory cytokines and chemokines, in response to the inflammatory stimuli lipopolysaccharide (LPS) and interferon-γ (IFN-γ)...
May 2016: Neurochemistry International
A Martínez-Esteve, R M Álvarez-Pérez, R Núñez-Vázquez, J L Tirado-Hospital, R García-Jiménez, J Povedano-Gómez, I Borrego-Dorado
OBJECTIVE: To assess the outcome and adverse-effects of the radioisotope synoviorthesis in paediatric and adolescent patients with haemophilia. MATERIAL AND METHODS: Prospective study of historical cohort was conducted. A total of 20 consecutive haemophiliacs with a mean age of 13.1 years (range 4-17) were included with a mean follow-up of 64.9 months (range 18-109). The diagnosis of synovitis was established on the basis of clinical follow-up including radiological images (radiography and/or MRI)...
January 2016: Revista Española de Medicina Nuclear e Imagen Molecular
Fabrícia Alvisi de Oliveira, Aline Silva Barreto, Lays G S Bomfim, Talita Rebeca S Leite, Priscila Lima Dos Santos, Roque Pacheco de Almeida, Ângela Maria da Silva, Malcolm S Duthie, Steven G Reed, Tatiana Rodrigues de Moura, Amélia Ribeiro de Jesus
BACKGROUND: While CD40L is typically a membrane glycoprotein expressed on activated T cells and platelets that binds and activates CD40 on the surface on antigen presenting cells, a soluble derivative (sCD40L) that appears to retain its biological activity after cleavage from cell membrane also exists. We recently reported that sCD40L is associated with clinical resolution of visceral leishmaniasis and protection against the disease. In the present study we investigated if this sCD40L is functional and exerts anti-parasitic effect in L...
2015: PloS One
Jorge Carlos Ruiz-Ruiz, Yolanda Beatriz Moguel-Ordoñez, Maira Rubi Segura-Campos
The leaves of Stevia rebaudiana Bertoni has nutrients and phytochemicals, which make it an adequate source for the extraction and production of functional food ingredients. Preclinical and clinical studies suggest therapeutic and pharmacological applications for stevia and their extracts because they are not toxic and exhibit several biological activities. This review presents the biological activity of Stevia rebaudiana Bertoni and their relationship to antidiabetic, anticariogenic, antioxidant, hypotensive, antihypertensive, antimicrobial, anti-inflamatory and anti-tumor activities...
October 19, 2015: Critical Reviews in Food Science and Nutrition
Paulina Koczurkiewicz, Jarosław Czyż, Irma Podolak, Katarzyna Wójcik, Agnieszka Galanty, Zbigniew Janeczko, Marta Michalik
Triterpene saponins (saponosides) are found in a variety of higher plants and display a wide range of pharmacological activities, including expectorant, anti-inflamatory, vasoprotective, gastroprotective and antimicrobial properties. Recently, a potential anticancer activity of saponins has been suggested by their cytotoxic, cytostatic, pro-apoptotic and anti-invasive effects. At high concentrations (more than 100 µM) saponins exert cytotoxic and haemolytic effects via permeabilization of the cell membranes...
2015: Acta Biochimica Polonica
Hua-Fang Sheng, Hong-Wei Zhou
Microbiome is a novel research field related with a variety of chronic inflamatory diseases. Technically, there are two major approaches to analysis of microbiome: metataxonome by sequencing the 16S rRNA variable tags, and metagenome by shot-gun sequencing of the total microbial (mainly bacterial) genome mixture. The 16S rRNA sequencing analyses pipeline includes sequence quality control, diversity analyses, taxonomy and statistics; metagenome analyses further includes gene annotation and functional analyses...
July 2015: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
Łukasz M Tekieli, Damian R Maciejewski, Karolina Dzierwa, Anna Kabłak-Ziembicka, Michał Michalski, Magdalena Wójcik-Pędziwiatr, Andrzej Brzychczy, Zbigniew Moczulski, Krzysztof Żmudka, Piotr Pieniążek
INTRODUCTION: Fibromuscular dysplasia (FMD) is an infrequent non-inflamatory disease of unknown etiology that affects mainly medium-size arteries. The prevalence of FMD among patients scheduled for endovascular treatment of carotid artery stenosis is unknown. AIM: To evaluate the prevalence and treatment options of carotid FMD in patients scheduled for carotid artery stenting (CAS). MATERIAL AND METHODS: Between Jan 2001 and Dec 2013, 2012 CAS procedures were performed in 1809 patients (66...
2015: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
M Pavkovic, R Angelovic, M Popova-Simjanovska, O Karanfilski, S Trpkovska-Terzieva, T Sotirova, L Cevreska, A Stojanovic
Immune thrombocytopenia (ITP) is an autoimmune disease characterized by thrombocytopenia due to platelet autoantibodies, causing an accelerated clearance of opsonized platelets by phagocytes. The etiology of ITP remains unclear, both genetic and environmental factors may have a role in the disease development. The aim of our study was to investigate a possible association of three single nucleotide polymorphisms (SNP) in the genes for interleukin beta (IL1B-511C/T), tumor necrosis factor beta (TNF+252G/A) and tumor necrosis factor alpha (TNFA-308G/A) with ITP...
2015: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
Iván Guerra, Fernando Bermejo
No abstract text is available yet for this article.
June 2015: Revista Española de Enfermedades Digestivas
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