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https://www.readbyqxmd.com/read/28089485/perceptual-error-analysis-of-human-and-synthesized-voices
#1
Marina Englert, Glaucya Madazio, Ingrid Gielow, Jorge Lucero, Mara Behlau
OBJECTIVE/HYPOTHESIS: To assess the quality of synthesized voices through listeners' skills in discriminating human and synthesized voices. STUDY DESIGN: Prospective study. METHODS: Eighteen human voices with different types and degrees of deviation (roughness, breathiness, and strain, with three degrees of deviation: mild, moderate, and severe) were selected by three voice specialists. Synthesized samples with the same deviations of human voices were produced by the VoiceSim system...
January 12, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28076814/gsmtx4-mechanism-of-inhibiting-mechanosensitive-ion-channels
#2
Radhakrishnan Gnanasambandam, Chiranjib Ghatak, Anthony Yasmann, Kazuhisa Nishizawa, Frederick Sachs, Alexey S Ladokhin, Sergei I Sukharev, Thomas M Suchyna
GsMTx4 is a spider venom peptide that inhibits cationic mechanosensitive channels (MSCs). It has six lysine residues that have been proposed to affect membrane binding. We synthesized six analogs with single lysine-to-glutamate substitutions and tested them against Piezo1 channels in outside-out patches and independently measured lipid binding. Four analogs had ∼20% lower efficacy than the wild-type (WT) peptide. The equilibrium constants calculated from the rates of inhibition and washout did not correlate with the changes in inhibition...
January 10, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28072804/multidisciplinary-care-of-unruptured-brain-arteriovenous-malformations-to-improve-symptomatic-headache-and-the-onset-progression-and-outcomes-of-unruptured-brain-arteriovenous-malformations
#3
Ling-Feng Lai, Min Chen, Jia-Xiang Chen, Kuang Zheng, Xu-Ying He, Xi-Feng Li, Xin Zhang, Jian Yin, Qiu-Jing Wang, Tuan-Ming Zou, Chuan-Zhi Duan
BACKGROUND: Symptomatic headaches attributed to unruptured brain arteriovenous malformations (ubAVMs) are very common and affect patients' quality life, but multidisciplinary care of ubAVMs to improve symptomatic headache remains unclear. OBJECTIVE: The objective is to identify the features of symptomatic headaches, and to obtain headache outcomes following multidisciplinary care of ubAVMs, as well as provide background on the natural history of ubAVMs. STUDY DESIGN: The features of symptomatic headaches and headache outcomes were analyzed in a large cohort of cases after multidisciplinary care of ubAVMs...
January 2017: Pain Physician
https://www.readbyqxmd.com/read/28072735/localized-type-volkmann-s-contracture-treated-with-tendon-transfer-and-tension-reduced-early-mobilization-a-case-report
#4
Yoshio Kaji, Osamu Nakamura, Konosuke Yamaguchi, Sachiko Tobiume, Tetsuji Yamamoto
RATIONALE: For localized type Volkmann's contracture, in which degeneration of the flexor digitorum profundus (FDP) muscle to one or two fingers and restriction of finger extension occur, dissection or excision of the affected muscle is usually recommended. However, these surgical procedures need relatively wide exposure of the muscle, because the FDP muscle is in the deep portion of the forearm. PATIENT CONCERNS: In this report, the case of a 35-year-old woman with localized type Volkmann's contracture is presented...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28071885/transparent-superhydrophobic-surface-with-varied-surface-tension-responsiveness-in-wettability-based-on-tunable-porous-silica-structure-for-gauging-liquid-surface-tension
#5
Yan Wang, Yingjie Zhu, Chunyang Zhang, Jun Li, Zisheng Guan
Any solid surface can spontaneously exhibit variational wettability toward liquids with varied surface tension (γ). However, this correspondence has seldom been proposed or used on an artificial superhydrophobic surface, which should be more remarkable and peculiar. Herein, we fabricated robust, transparent superhydrophobic surfaces, utilizing acid-catalyzed/base-catalyzed silica (AC-silica and BC-silica) particles combined with candle soot template for structural construction and CVD process for chemical modifi-cation...
January 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28069156/effectiveness-of-a-relaxation-intervention-progressive-muscle-relaxation-and-guided-imagery-techniques-to-reduce-anxiety-and-improve-mood-of-parents-of-hospitalized-children-with-malignancies-a-randomized-controlled-trial-in-republic-of-cyprus-and-greece
#6
Theologia Tsitsi, Andreas Charalambous, Evridiki Papastavrou, Vasilios Raftopoulos
PURPOSE: To explore the effect of Progressive Muscle Relaxation (PMR) and Guided Imagery (GI),in reducing anxiety levels among parents of children diagnosed with any type of malignancy receiving active treatment at a Paediatric Oncology Unit in Republic of Cyprus and in Greece. METHOD: A randomized non-blinded control trial was conducted between April 2012 to October 2013, at two public paediatric hospitals. Fifty four eligible parents of children hospitalized with a malignancy were randomly assigned to the intervention (PMR and GI) (n = 29) and a control group (n = 25)...
February 2017: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://www.readbyqxmd.com/read/28063867/-it-s-like-heart-failure-it-s-chronic%C3%A2-and-it-will-kill-you-a-qualitative-analysis-of-burnout-among-hospice-and-palliative-care-clinicians
#7
Dio Kavalieratos, Daniel E Siconolfi, Karen E Steinhauser, Janet Bull, Robert M Arnold, Keith M Swetz, Arif H Kamal
CONTEXT: Although prior surveys have identified rates of self-reported burnout among palliative care clinicians as high as 62%, limited data exist to elucidate the causes, ameliorators, and effects of this phenomenon. OBJECTIVES: We explored burnout among palliative care clinicians, specifically their experiences with burnout, their perceived sources of burnout, and potential individual, interpersonal, organizational, and policy-level solutions to address burnout...
January 4, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28063521/dynamic-interfacial-tension-of-surfactant-solutions
#8
REVIEW
R Miller, E V Aksenenko, V B Fainerman
The dynamics of surfactant interfacial layers was first discussed more than a century ago. In 1946 the most important work by Ward and Tordai was published which is still the theoretical basis of all new models to describe the time dependence of interfacial properties. In addition to the diffusion controlled adsorption mechanism, many other models have been postulated in literature, however, well performed experiments with well defined surfactant systems have shown that the diffusional transport is the main process governing the entire formation of surfactant adsorption layers...
December 24, 2016: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28060270/building-finite-element-models-to-investigate-zebrafish-jaw-biomechanics
#9
Lucy H Brunt, Karen A Roddy, Emily J Rayfield, Chrissy L Hammond
Skeletal morphogenesis occurs through tightly regulated cell behaviors during development; many cell types alter their behavior in response to mechanical strain. Skeletal joints are subjected to dynamic mechanical loading. Finite element analysis (FEA) is a computational method, frequently used in engineering that can predict how a material or structure will respond to mechanical input. By dividing a whole system (in this case the zebrafish jaw skeleton) into a mesh of smaller 'finite elements', FEA can be used to calculate the mechanical response of the structure to external loads...
December 3, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28060172/applications-of-burow-s-grafts-in-the-reconstruction-of-mohs-micrographic-surgery-defects
#10
Anastasia Benoit, Brian C Leach, Joel Cook
BACKGROUND: Surgical defects in anatomically challenging locations, such as near free margins or crossing cosmetic subunits, may present reconstructive challenges to the dermatologic surgeon. For selected defects, Burow's grafts may produce functional and aesthetic results in a single operative session. OBJECTIVE: To describe the applications of the Burow's graft technique for the repair of defects after Mohs micrographic surgery. METHODS: An institutional review board-approved retrospective database review of surgical defects repaired with Burow's grafting after Mohs micrographic surgery at the Medical University of South Carolina was performed...
December 29, 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28055093/manual-therapy-lowers-psychological-aggravations-in-patients-with-tension-type-headache
#11
Melissa Yunting Tang, Hollis H King
No abstract text is available yet for this article.
January 1, 2017: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/28054178/hemosuccus-pancreaticus-caused-by-a-mucinous-cystic-neoplasm-of-the-pancreas
#12
Yuri Matsumoto, Hiroshi Miyamoto, Akira Fukuya, Fumika Nakamura, Takahiro Goji, Shinji Kitamura, Tetsuo Kimura, Koichi Okamoto, Masahiro Sogabe, Naoki Muguruma, Mitsuo Shimada, Yoshimi Bando, Tetsuji Takayama
Hemosuccus pancreaticus is a gastrointestinal hemorrhage through the main pancreatic duct. Here, we report a rare case of hemosuccus pancreaticus due to a mucinous cystic neoplasm of the pancreas. A 62-year-old woman who had been followed for a branch duct intraductal papillary mucinous neoplasm visited our emergency room due to severe abdominal pain and bloody discharge. Computed tomography revealed that the pancreatic cyst increased the tension of the wall and a high-density area indicative of bleeding into the cyst was observed...
January 4, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/28053908/reconstruction-of-partial-maxillectomy-defect-with-a-buccal-fat-pad-flap-and-application-of-4-hexylresorcinol-a-case-report
#13
Hyun Seok, Min-Keun Kim, Seong-Gon Kim
Mucoepidermoid carcinoma (MEC) is the most common type of malignant neoplasm in the minor salivary gland. The hard palate is a frequently involved site of MEC. The treatment of low-grade MEC on the hard palate is wide local resection with a tumor-free margin. In the present case, the maxillary defect was reconstructed using a buccal fat pad (BFP) flap, followed by application of 4-hexylresorcinol (4HR) ointment for 2 weeks. The grafted BFP successfully covered the tumor resection defect without tension and demonstrated complete re-epithelialization without any complications...
December 2016: Journal of the Korean Association of Oral and Maxillofacial Surgeons
https://www.readbyqxmd.com/read/28043109/a-possible-pathogenic-linkage-among-headache-migraine-and-nocturnal-enuresis-in-children
#14
Pietro Ferrara, Livia Dell'Aquila, Giacomo Perrone, Giulia Spina, Francesco Miconi, Valentina Rapaccini, Ester Del Vescovo, Vincenzo Di Lazzaro, Alberto Verrotti
PURPOSE: This study aims to evaluate the prevalence of headaches and migraine in children with nocturnal enuresis (NE) and to improve knowledge on these conditions. In particular, for this purpose, a possible pathogenic relationship linking both conditions and the impact of headaches and migraine on NE persistence was evaluated. METHODS: Researchers enrolled 123 children with NE, aged between 5 and 15 years, referred to the Service of Pediatrics, Campus Bio-Medico University Hospital of Rome between January 2014 and January 2015...
December 2016: International Neurourology Journal
https://www.readbyqxmd.com/read/28042309/the-link-between-vascular-dysfunction-bladder-ischemia-and-aging-bladder-dysfunction
#15
REVIEW
Karl-Erik Andersson, Donna B Boedtkjer, Axel Forman
The vascular supply to the human bladder is derived mainly from the superior and inferior vesical arteries, the latter being directly connected to the internal iliac artery. Aging is associated with an impairment of blood vessel function and changes may occur in the vasculature at the molecular, cellular and functional level. Pelvic arterial insufficiency may play an important role in the development of bladder dysfunctions such as detrusor overactivity (DO) and the overactive bladder syndrome. Chronic ischemia-related bladder dysfunction may progress to bladder underactivity and it would be desirable to treat not only lower urinary tract symptoms (LUTS) induced by chronic ischemia, but also the progression of the morphological bladder changes...
January 2017: Therapeutic Advances in Urology
https://www.readbyqxmd.com/read/28027588/integrating-multiple-data-sources-in-species-distribution-modeling-a-framework-for-data-fusion
#16
Krishna Pacifici, Brian J Reich, David A W Miller, Beth Gardner, Glenn Stauffer, Susheela Singh, Alexa McKerrow, Jaime A Collazo
The last decade has seen a dramatic increase in the use of species distribution models (SDMs) to characterize patterns of species' occurrence and abundance. Efforts to parameterize SDMs often create a tension between the quality and quantity of data available to fit models. Estimation methods that integrate both standardized and non-standardized data types offer a potential solution to the trade-off between data quality and quantity. Recently several authors have developed approaches for jointly modeling two sources of data (one of high quality and one of lesser quality)...
December 27, 2016: Ecology
https://www.readbyqxmd.com/read/28026126/recapitulating-the-micromechanical-behavior-of-tension-and-shear-in-a-biomimetic-hydrogel-for-controlling-tenocyte-response
#17
Dharmesh Patel, Sadhana Sharma, Stephanie J Bryant, Hazel R C Screen
A fiber composite system is presented which recapitulates the fiber-composite-like nature of tissues and generates similar modes of shear and tension. The shear/tension ratio can be customized during composite manufacture and incorporates viable cells. The system is a valuable tool for mechanotransduction research, providing a platform with physiologically relevant conditions for investigating cell behavior in different tissue types.
December 27, 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28025332/transgenic-tbk1-mice-have-features-of-normal-tension-glaucoma
#18
John H Fingert, Kathy Miller, Adam Hedberg-Buenz, Ben R Roos, Carly J Lewis, Robert F Mullins, Michael G Anderson
Duplication of the TBK1 gene is associated with 1-2% of normal tension glaucoma, a common cause of vision loss and blindness that occurs without grossly abnormal intraocular pressure. We generated a transgenic mouse that has one copy of the human TBK1 gene (native promoter and gene structure) incorporated into the mouse genome (Tg-TBK1). Expression of the TBK1 transgene in the retinae of these mice was demonstrated by real-time PCR. Using immunohistochemistry TBK1 protein was predominantly localized to the ganglion cell layer of the retina, the cell type most affected by glaucoma...
December 26, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/28018233/carbonic-anhydrase-iii-is-expressed-in-mouse-skeletal-muscles-independent-of-fiber-type-specific-myofilament-protein-isoforms-and-plays-a-role-in-fatigue-resistance
#19
Han-Zhong Feng, J-P Jin
Carbonic anhydrase III (CAIII) is a metabolic enzyme and a regulator for intracellular pH. CAIII has been reported with high level expression in slow twitch skeletal muscles. Here we demonstrate that CAIII is expressed in multiple slow and fast twitch muscles of adult mouse independent of the expression of myosin isoforms. Expressing similar fast type of myofilament proteins, CAIII-positive tibial anterior (TA) muscle exhibits higher tolerance to fatigue than that of CAIII-negative fast twitch extensor digitorum longus (EDL) muscle in in situ contractility studies...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/28017412/intracorporal-knot-tying-techniques-which-is-the-right-one
#20
Philipp Romero, Felix Nickel, Maisha Mantel, Giovanni Frongia, Alina Rossler, Karl-Friedrich Kowalewski, Beat Peter Müller-Stich, Patrick Günther
INTRODUCTION: Intracorporal knot tying (ICKT) and suturing in minimal invasive surgery (MIS) represent a key skill for advanced procedures such as Nissen fundoplication. Suture placement under tension is particularly challenging during MIS. The aim of this study was to compare ICKT of the common surgical square knot and the slipping knot on a simulated suture placement under tension. Furthermore, we objectively assessed the surgical skill of ICKT following 3hours of hands-on training...
December 20, 2016: Journal of Pediatric Surgery
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