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https://www.readbyqxmd.com/read/29142384/hypercapnic-respiratory-failure-in-case-of-chiari-1-5-malformation-case-report-and-review-of-the-literature
#1
Viralkumar M Vasani, Subhas Kanti Konar, S Satish
Type 2 respiratory failure is defined as hypercapnia associated with hypoxia. Chiari 1.5 is known as herniation of the cerebellar tonsils along with brain stem and fourth ventricle. We report a 35-year-old male who presented with acute hypercapnic respiratory failure (Type 2), without any preexisting neurological or respiratory abnormality. Analysis of blood gases in emergency revealed a pH of 7.12, pCO2 of 132 mmHg, and arterial oxygen tension of 118 mm Hg. He was intubated and ventilated. Magnetic resonance imaging brain revealed herniation of the cerebellar tonsils along with brain stem and fourth ventricle...
October 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29142072/salt-bridges-gate-alpha-catenin-activation-at-intercellular-junctions
#2
Samantha Barrick, Jing Li, Xinyu Kong, Alokananda Ray, Emad Tajkhorshid, Deborah Leckband
Cadherin complexes transduce force fluctuations at junctions to activate signals that reinforce stressed intercellular contacts. α-Catenin is an identified force transducer within cadherin complexes that is autoinhibited under low tension. Increased force triggers a conformational change that exposes a cryptic site for the actin-binding protein vinculin. This study tested predictions that salt bridges within the force-sensing core modulate α-catenin activation. Studies with a fluorescence resonance energy transfer (FRET)-based α-catenin conformation sensor demonstrated that the salt-bridge mutations R551A and D503N each enhance α-catenin activation in live cells, but R551A has a greater impact...
November 15, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/29141686/anisotropic-m%C3%A3-ller-glial-scaffolding-supports-a-multiplex-lattice-mosaic-of-photoreceptors-in-zebrafish-retina
#3
Mikiko Nagashima, Jeremy Hadidjojo, Linda K Barthel, David K Lubensky, Pamela A Raymond
BACKGROUND: The multiplex, lattice mosaic of cone photoreceptors in the adult fish retina is a compelling example of a highly ordered epithelial cell pattern, with single cell width rows and columns of cones and precisely defined neighbor relationships among different cone types. Cellular mechanisms patterning this multiplex mosaic are not understood. Physical models can provide new insights into fundamental mechanisms of biological patterning. In earlier work, we developed a mathematical model of photoreceptor cell packing in the zebrafish retina, which predicted that anisotropic mechanical tension in the retinal epithelium orients planar polarized adhesive interfaces to align the columns as cone photoreceptors are generated at the retinal margin during post-embryonic growth...
November 15, 2017: Neural Development
https://www.readbyqxmd.com/read/29140286/evidence-to-use-botulinum-toxin-injections-in-tension-type-headache-management-a-systematic-review
#4
REVIEW
Mieszko Wieckiewicz, Natalia Grychowska, Marek Zietek, Gniewko Wieckiewicz, Joanna Smardz
Tension-type headache (TTH) is the most common type of chronic recurring head pain. It can occur twice as often in women as in men. It is the most common type of headache. Its lifetime prevalence is 30% to 78% in the general population. TTH treatment should be multilevel. It often consists of taking pain medication, muscle relaxants, antidepressants, using biofeedback therapy, acupuncture, and attending behavioral therapy. Several clinical trials also suggest that botulinum toxin (BTX) may be an effective treatment option for such patients...
November 15, 2017: Toxins
https://www.readbyqxmd.com/read/29139113/prevalence-of-headache-in-patients-with-mitochondrial-disease-a-cross-sectional-study
#5
Torsten Kraya, Marcus Deschauer, Pushpa Raj Joshi, Stephan Zierz, Charly Gaul
BACKGROUND: Mitochondrial diseases are a heterogeneous group of diseases with different phenotypes and genotypes. Headache and, particularly migraine, seems to occur often in patients with MELAS and in patients with CPEO phenotypes. The International Classification of Headache Disorders (ICHD-3 beta) has classified headache as a secondary entity only in MELAS patients. Other headache phenotypes in mitochondrial diseases are not considered in ICHD-3beta. In this study, we analyzed headache phenomenology in a large group of patients with mitochondrial disorders...
November 15, 2017: Headache
https://www.readbyqxmd.com/read/29137568/first-dorsal-metatarsal-artery-perforator-flap-to-cover-great-toe-defect
#6
Roongsak Limthongthang, Perajit Eamsobhana
BACKGROUND: There were very few options available for distal foot and toe defects that required a vascularized flap for coverage. As such, the use of a free flap was often justified in this region of the foot. The use of perforator flaps has created a new subset of local tissue transfer alternatives that increases the potential that the difficulties associated with microvascular tissue transfers could be avoided. The first dorsal metatarsal artery (FDMA) perforator flap was one variant of this new type of tissue transfer...
September 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/29135136/-structural-morphological-changes-of-the-connective-tissue-of-the-vaginal-mucosa-and-perineal-skin-in-women-with-stress-urinary-incontinence
#7
V N Pavlov, A G Yashchuk, A A Kazikhinurov, I I Musin, R M Zauinullina, V A Kulavskii, A A Kazikhinurova
AIM: To investigate the morphological and structural changes in the connective tissue of the vaginal mucosa and perineal skin in women with stress urinary incontinence. MATERIALS AND METHODS: From 2010 to 2013, 71 patients of reproductive age with stress incontinence were observed. The control group comprised 80 women, who also underwent biopsy of the vaginal mucosa and perineal skin. The sections of specimens were stained by Van Gieson, Mallory and Weigert. In immunohistochemical studies, rabbit antibodies specific for collagen types I, III, and IV were placed on each section...
October 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/29124521/successful-peritoneal-dialysis-using-a-percutaneous-tube-for-peritoneal-drainage-in-an-extremely-low-birth-weight-infant-a-case-report
#8
Satoshi Yokoyama, Takayuki Nukada, Yuka Ikeda, Shigeto Hara, Akira Yoshida
BACKGROUND: Peritoneal dialysis (PD) for acute kidney injury (AKI) of newborns has been performed safely. AKI occurs in 8 to 24% of extremely low birth weight (ELBW) infants. Although PD has only been used occasionally in ELBW infants, prognosis is poor for ELBW infants with AKI. Several reports have described successful PD in these infants, but no guideline-based evidence concerning indications for renal replacement therapy in ELBW infants are currently available. Here, we report on our experience with PD in an ELBW infant with AKI resulting from septic shock...
November 9, 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/29120129/the-role-of-electromyographic-blink-reflex-in-the-evaluation-of-headache-incidence
#9
Marijan Cesarik, Iris Zavoreo, Lucija Zadro-Matovina, Tomislav Madžar, Vanja Bašić Kes
Migraine and tension type headache are the most common disabling primary headache disorders. Epidemiological studies have documented their high prevalence and high socioeconomic and personal impacts. According to recent data, migraine ranks as the third most prevalent disorder and seventh-highest specific cause of disability worldwide. Tension-type headache has lifetime prevalence in the general population ranging between 30% and 78% in different studies. According to the International Classification of Headache Disorders, 3rd edition, there also are many other headaches but their incidence in general population is lower than the previously mentioned headaches...
March 2017: Acta Clinica Croatica
https://www.readbyqxmd.com/read/29119949/balancing-strength-hardness-and-ductility-of-cu-sub-64-sub-zr-sub-36-sub-nanoglasses-via-embedded-nanocrystals
#10
Wu-Rong Jian, Liang Wang, Xiaohu Yao, Sheng-Nian Luo
Superplasticity can be achieved in nanoglasses but at the expense of strength, and such a loss can be mitigated via embedding stronger nanocrystals, i.e., forming nanoglass/nanocrystal composites. As an illustrative case, we investigate plastic deformation of Cu<sub>64</sub>Zr<sub>36</sub> nanoglass/nanocrystalline Cu composites during uniaxial tension and nanoindentation tests with molecular dynamics simulations. With increasing fraction of nanocrystalline grains, the tensile strength of the composite is enhanced, while its ductility decreases...
November 9, 2017: Nanotechnology
https://www.readbyqxmd.com/read/29118453/prediction-of-visual-field-progression-in-patients-with-primary-open-angle-glaucoma-mainly-including-normal-tension-glaucoma
#11
Koji Nitta, Ryotaro Wajima, Gaku Tachibana, Sachie Inoue, Tatsuya Ohigashi, Naomi Otsuka, Hiroaki Kurashima, Kazunori Santo, Masayo Hashimoto, Hidetoshi Shibahara, Mai Hirukawa, Kazuhisa Sugiyama
An objective method to predict individual visual field progression will contribute to realise personalised medication. The purpose of this study was to establish a predictive formula for glaucomatous visual field progression in patients with Primary open-angle glaucoma, mainly including normal tension glaucoma. This study was a large-scale, longitudinal and retrospective study including 498 eyes of 312 patients visiting from June 2009 to May 2015. In this analysis, 191 eyes of 191 patients meeting all eligible criteria were used...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29116804/coupled-interfacial-tension-and-phase-behavior-model-based-on-micellar-curvatures
#12
Victor Torrealba, Russell T Johns
This paper introduces a consistent and robust model that predicts interfacial tensions for all microemulsion Winsor types and overall compositions. The model incorporates film bending arguments and Huh's equation, and is coupled to phase behavior so that simultaneous tuning of both interfacial tension (IFT) and phase behavior is possible. The oil-water interfacial tension and characteristic length are shown to be related to each other through the hydrophilic-lipophilic deviation (). The phase behavior is tied to the micelle curvatures, without the need for using net average curvature (NAC)...
November 8, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29116056/excess-area-dependent-scaling-behavior-of-nano-sized-membrane-tethers
#13
Ramakrishnan Natesan, K K Sreeja, Arpita Roychoudhuri, David M Eckmann, Portonovo S Ayyaswamy, Tobias Baumgart, Thomas Pucadyil, Shivprasad Vitthal Patil, Valerie M Weaver, Ravi Radhakrishnan
Thermal fluctuations in cell membranes manifest as an excess area (Aex) which governs a multitude of physical process at the sub-micron scale. We present a theoretical framework, based on an in silico tether pulling method, which may be used to reliably estimate Aex in live cells. We perform our simulations in two different thermodynamic ensembles: (i) the constant projected area and (ii) the constant frame tension ensembles and show the equivalence of our results in the two. The tether forces estimated from our simulations compare well with our experimental measurements for tethers extracted from ruptured GUVs and HeLa cells...
November 8, 2017: Physical Biology
https://www.readbyqxmd.com/read/29110775/primary-headaches
#14
Gerrit L J Onderwater, Robin M Van Dongen, Ronald Zielman, Gisela M Terwindt, Michel D Ferrari
Headache disorders, characterized by recurrent headache, are among the most common disorders of the nervous system. Primary headache disorders are by definition not the result of any other underlying disease or process. In this chapter the current status of cerebrospinal fluid (CSF) research and applications for clinical practice for the three main primary headaches - migraine, cluster headache, and tension-type headache - will be described. Primary headaches are clinically diagnosed disorders, with typically normal routine CSF measurements...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29110509/stress-management-for-headaches-in-children-and-adolescents-a-review-and-practical-recommendations-for-health-promotion-programs-and-well-being
#15
Anastasia Bougea, Nikolaos Spantideas, George P Chrousos
Stress is considered to be the most common factor reported to trigger headaches in children and adolescents. Although tension-type headache and migraine are the two most common types of headache in children and adolescents, they are often untreated, ignoring their stressful background. We provide a narrative review of the available evidence for health-care professionals involved in stress-related headache management and health promotion programs. An integrative plan is delivered through lifestyle improvement and biopsychosocial modifying stress response techniques...
January 1, 2017: Journal of Child Health Care: for Professionals Working with Children in the Hospital and Community
https://www.readbyqxmd.com/read/29108598/disentangling-the-reciprocal-relationship-between-change-in-crime-and-racial-ethnic-change
#16
Lyndsay N Boggess
Prior research has found that racial/ethnic change and residential instability are positively related to neighborhood crime. However, the process of racial/ethnic change differentially influences crime above and beyond residential instability. While both processes affect crime through the disruption of existing social ties, racial/ethnic change has additional consequences for crime by heightening racial/ethnic tensions and undercutting cross-group interactions. This means racial/ethnic change is a different process than residential instability, and suggests that neighborhoods experiencing high rates of instability and high rates of racial/ethnic change may be particularly susceptible to crime...
November 2017: Social Science Research
https://www.readbyqxmd.com/read/29107003/elevated-wall-tension-initiates-interleukin-6-expression-and-abdominal-aortic-dilation
#17
Adam W Akerman, Robert E Stroud, Ryan W Barrs, R Tyler Grespin, Lindsay T McDonald, R Amanda C LaRue, Rupak Mukherjee, John S Ikonomidis, Jeffery A Jones, Jean Marie Ruddy
INTRODUCTION: Hypertension (HTN) has long been associated with abdominal aortic aneurysm (AAA) development and these cardiovascular pathologies are biochemically characterized by elevated plasma levels of Angiotensin-II (AngII) as well as interleukin-6 (IL-6). A biologic relationship between HTN and AAA has not been established, however. Accordingly, the objective of this study was to evaluate whether elevated tension may initiate IL-6 production to accumulate monocyte/macrophages and promote dilation of the abdominal aorta (AA)...
October 26, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29104684/effect-of-flunarizine-on-serum-glutamate-levels-and-its-correlation-with-headache-intensity-in-chronic-tension-type-headache-patients
#18
Khairul Putra Surbakti, Hasan Sjahrir, Rosita Juwita-Sembiring, Erna Mutiara
BACKGROUND: Some of the excitatory neurotransmitters including glutamate have been suggested to be involved in headache pathophysiology. To our knowledge, there is a lack of publication about flunarizine efficacy in chronic tension-type headache (CTTH) treatments and the roles of glutamate in CTTH pathophysiology. AIM: This study aimed to investigate the flunarizine effect on serum levels of glutamate and its correlation with headache intensity based on the Numeric Rating Scale for pain (NRS) scores in CTTH patients...
October 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29104631/ocular-pulse-amplitude-in-different-types-of-glaucoma-using-dynamic-contour-tonometry-diagnosis-and-follow-up-of-glaucoma
#19
Lingyan Cheng, Yuzhi Ding, Xuanchu Duan, Zhifeng Wu
The aim of the present study was to compare the ocular pulse amplitude (OPA) in patients with different types of glaucoma using dynamic contour tonometry (DCT), to evaluate ocular and systemic factors associated with the OPA and to verify whether OPA measured by DCT is an independent predictor for glaucoma diagnosis. A total of 217 eyes of 217 participants in the following five groups were included in this cross-sectional study: Chronic angle closure glaucoma (CACG), primary open angle glaucoma, normal tension glaucoma (NTG), suspected open angle glaucoma (SOAG) and normal control (NC)...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29103349/determination-of-surface-energies-of-hot-melt-extruded-sugar-starch-pellets
#20
Chi-Wah Yeung, Hubert Rein
Hot-melt extruded sugar-starch pellets are an alternative for commercial sugar spheres, but their coating properties remain to be studied. Both the European Pharmcopoeia 8.6 and the United States Pharmacopoeia 40 specify the composition of sugar-starch pellets without giving requirements for the manufacturing process. Due to various fabrication techniques, the physicochemical properties of pellets may differ. Therefore, the adhesion energies of three coating dispersions (sustained, enteric and immediate release) on different types of pellets were investigated...
November 6, 2017: Pharmaceutical Development and Technology
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