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https://www.readbyqxmd.com/read/29791944/the-global-burden-of-headache
#1
Deanna Saylor, Timothy J Steiner
At the turn of the century, most of the world's population lived in regions where the prevalence of headache was unknown and its impact poorly understood. Lifting The Burden (LTB), a nonprofit organization in official relations with the World Health Organization, established the Global Campaign against Headache, with the ultimate purpose of reducing the burden of headache worldwide. First, the scope and scale of this burden had to be known. LTB embarked upon a program of population-based studies in countries in all world regions in order to achieve its aim...
April 2018: Seminars in Neurology
https://www.readbyqxmd.com/read/29789115/hints-on-diagnosing-and-treating-headache
#2
Arne May
BACKGROUND: Headache, like dizziness, is one of the more common presenting complaints in outpatient care and in the emergency room. More than 200 varieties of headache have been described, and the false impression may arise that the diagnosis and treatment of these syndromes is a highly challenging task. METHODS: This review is based on pertinent articles retrieved by a selective search in PubMed. RESULTS: In primary headache, the headache is not a symptom but a disease in its own right...
April 27, 2018: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/29788423/variability-in-adolescent-portal-privacy-features-how-the-unique-privacy-needs-of-the-adolescent-patient-create-a-complex-decision-making-process
#3
Marianne Sharko, Lauren Wilcox, Matthew K Hong, Jessica S Ancker
Objective: Medical privacy policies, which are clear-cut for adults and young children, become ambiguous during adolescence. Yet medical organizations must establish unambiguous rules about patient and parental access to electronic patient portals. We conducted a national interview study to characterize the diversity in adolescent portal policies across a range of institutions and determine the factors influencing decisions about these policies. Methods: Within a sampling framework that ensured diversity of geography and medical organization type, we used purposive and snowball sampling to identify key informants...
May 17, 2018: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29786656/temperature-effects-on-force-and-actin%C3%A2-myosin-interaction-in-muscle-a-look-back-on-some-experimental-findings
#4
REVIEW
K W Ranatunga
Observations made in temperature studies on mammalian muscle during force development, shortening, and lengthening, are re-examined. The isometric force in active muscle goes up substantially on warming from less than 10 °C to temperatures closer to physiological (>30 °C), and the sigmoidal temperature dependence of this force has a half-maximum at ~10 °C. During steady shortening, when force is decreased to a steady level, the sigmoidal curve is more pronounced and shifted to higher temperatures, whereas, in lengthening muscle, the curve is shifted to lower temperatures, and there is a less marked increase with temperature...
May 22, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29785630/calcium-channels-rho-kinase-protein-kinase-c-and-phospholipase-c-pathways-mediate-mercury-chloride-induced-myometrial-contractions-in-rats
#5
Swati Koli, Atul Prakash, Soumen Choudhury, Rajesh Mandil, Satish K Garg
Adverse effects of mercury on female reproduction are reported; however, its effect on myogenic activity of uterus and mechanism thereof is obscure. Present study was undertaken to unravel the mechanistic pathways of mercuric chloride (HgCl2 )-induced myometrial contraction in rats. Isometric tension in myometrial strips of rats following in vitro exposure to HgCl2 was recorded using data acquisition system-based physiograph. HgCl2 produced concentration-dependent (10 nM-100 μM) uterotonic effect which was significantly (p < 0...
May 21, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29783221/hygienic-assessment-of-different-forms-of-physical-education-lessons-organization-in-primary-school
#6
Oleksandra S Kondratiuk, Maria M Korshun, Sergii I Garkavyi, Sergii S Garkavyi, Liudmyla A Stasiuk, Olena V Dema, Olga O Sokolovska
OBJECTIVE: Introduction: Different forms of physical education lessons organization, including swimming classes were introduced in education process without studying of its healthsaving effectiveness. The aim of this study was hygienic assessment of different forms of physical education lessons organization in primary school. PATIENTS AND METHODS: Materials and methods: Cross-sectional study was conducted in two schools with different organization of physical education lessons...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29781073/the-impact-of-concurrent-pelvic-organ-prolapse-reconstructive-surgery-on-midurethral-sling-procedure-outcome
#7
Buğra Çoşkun, Orhan S Aksakal, Bora Çoşkun, Engin Yurtçu, Mehmet Özgür Akkurt, Özgül Kafadar, Melike Doğanay
OBJECTIVES: To evaluate the effect of concurrent pelvic organ prolapse (POP) reconstructive surgery on midurethral sling (MUS) procedure outcome. MATERIAL AND METHODS: The present retrospective study included 300 women with urodynamically diagnosed stress urinary incontinence that underwent MUS procedures with or without concurrent POP reconstructive surgery. Patients were divided into four groups according to the performed surgery; 1) transobturator tape (TOT), 2) TOT with POP surgery (anterior colporrhaphy, posterior colporrhaphy and vaginal hysterectomy), 3) tension free vaginal tape (TVT), 4) TVT with POP surgery...
2018: Ginekologia Polska
https://www.readbyqxmd.com/read/29778791/evolutionary-transitions-in-controls-reconcile-adaptation-with-continuity-of-evolution
#8
REVIEW
Alexander V Badyaev
Evolution proceeds by accumulating functional solutions, necessarily forming an uninterrupted lineage from past solutions of ancestors to the current design of extant forms. At the population level, this process requires an organismal architecture in which the maintenance of local adaptation does not preclude the ability to innovate in the same traits and their continuous evolution. Representing complex traits as networks enables us to visualize a fundamental principle that resolves tension between adaptation and continuous evolution: phenotypic states encompassing adaptations traverse the continuous multi-layered landscape of past physical, developmental and functional associations among traits...
May 17, 2018: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29772991/reconstruction-plate-based-antibiotic-cement-spacers-clinical-outcomes-and-description-of-technique
#9
Aditya V Maheshwari, Robert Pivec, Roby Abraham, Qais Naziri
The standard of care for chronic deep peri-prosthetic hip infection is a two-stage exchange with placement of a temporary antibiotic cement spacer and treatment with intravenous antibiotics. Several commercially available cement spacer options exist. We report on a novel antibiotic spacer that may be an efficient, cost-effective alternative. Medical records of all patients treated for deep peri-prosthetic hip infection after total hip arthroplasty between 2004 and 2012 were reviewed. Each antibiotic spacer was constructed from a 12- to 16-hole recon plate bent to provide adequate soft tissue tension and a cement ball that matched the acetabulum...
2018: Journal of Long-term Effects of Medical Implants
https://www.readbyqxmd.com/read/29771988/variables-associated-with-sleep-quality-in-chronic-tension-type-headache-a-cross-sectional-and-longitudinal-design
#10
Elena Benito-González, Maria Palacios-Ceña, Juan J Fernández-Muñoz, Matteo Castaldo, Kelun Wang, Antonella Catena, Lars Arendt-Nielsen, César Fernández-de-Las-Peñas
OBJECTIVE: To investigate variables associated at baseline (cross-sectional design) and at one year (longitudinal design) with the quality of sleep in chronic tension-type headache (CTTH). METHODS: One hundred and eighty (n = 180) and 135 individuals with CTTH participated in the cross-sectional and longitudinal design respectively. Clinical features were collected with a 4-weeks headache diary at baseline and one-year follow-up. Sleep quality was assessed at baseline and 1-year follow-up with the Pittsburgh Sleep Quality Index...
2018: PloS One
https://www.readbyqxmd.com/read/29771915/inactivation-of-bpsl1039-1040-atp-binding-cassette-transporter-reduces-intracellular-survival-in-macrophages-biofilm-formation-and-virulence-in-the-murine-model-of-burkholderia-pseudomallei-infection
#11
Peechanika Pinweha, Pornpan Pumirat, Jon Cuccui, Niramol Jitprasutwit, Veerachat Muangsombut, Varintip Srinon, Usa Boonyuen, Parameth Thiennimitr, Paiboon Vattanaviboon, Felipe Cia, Sam Willcocks, Gregory J Bancroft, Brendan W Wren, Sunee Korbsrisate
Burkholderia pseudomallei, a gram-negative intracellular bacillus, is the causative agent of a tropical infectious disease called melioidosis. Bacterial ATP-binding cassette (ABC) transporters import and export a variety of molecules across bacterial cell membranes. At present, their significance in B. pseudomallei pathogenesis is poorly understood. We report here characterization of the BPSL1039-1040 ABC transporter. B. pseudomallei cultured in M9 medium supplemented with nitrate, demonstrated that BPSL1039-1040 is involved in nitrate transport for B...
2018: PloS One
https://www.readbyqxmd.com/read/29770193/hyperbaric-oxygen-therapy-as-adjunctive-strategy-in-treatment-of-glioblastoma-multiforme
#12
REVIEW
Lei Huang, Warren Boling, John H Zhang
Glioblastoma multiforme (GBM) is the most common type of malignant intracranial tumor in adults. Tumor tissue hypoxia, high mitotic rate, and rapid tumor spread account for its poor prognosis. Hyperbaric oxygen therapy (HBOT) may improve the sensitivity of radio-chemotherapy by increasing oxygen tension within the hypoxic regions of the neoplastic tissue. This review summarizes the research of HBOT applications within the context of experimental and clinical GBM. Limited clinical trials and preclinical studies suggest that radiotherapy immediately after HBOT enhances the effects of radiotherapy in some aspects...
January 2018: Medical Gas Research
https://www.readbyqxmd.com/read/29768241/effects-of-fe-sds-and-au-nanoparticles-on-p-aeruginosa-bacterial-growth-and-biosurfactant-production
#13
Neda Alamdar, Behnam Rasekh, Fatemeh Yazdian
The aim of this study was to evaluate the effects of iron (Fe)/SDS and gold (Au) nanoparticles on growth and biosurfactant production of Pseudomonas aeruginosa PBCC5 . The concentrations of the nanoparticles used were 1, 500 and 1000 mg/l. In this research, the surface tension of biosurfactant, dry weight of biosurfactant and biomass, emulsification indexes (E24 ) were measured and transmission electron microscopy analysis was used to monitor the nanoparticles. The test results showed that the effect of nanoparticles on the bacterial growth and biosurfactant production varied corresponding to the type and concentration of nanoparticles...
June 2018: IET Nanobiotechnology
https://www.readbyqxmd.com/read/29765566/efficacy-of-combination-of-viola-odorata-rosa-damascena-and-coriandrum-sativum-in-prevention-of-migraine-attacks-a-randomized-double-blind-placebo-controlled-clinical-trial
#14
Mohadese Kamali, Rostam Seifadini, Hoda Kamali, Mitra Mehrabani, Yunes Jahani, Haleh Tajadini
Background: Migraine is the second most common type of headache after tension headaches. In Iranian traditional medicine several herbal drugs are used for the treatment of headache. Including, a product of Iranian traditional medicine, a combination of Viola odorata L. flowers, Rosa damascena L. flowers and Coriandrum sativum L. fruits. Objective: To determine the effectiveness of a combination of Viola odorata flowers, Rosa damascene flowers and Coriandrum sativum fruits on severity, duration and frequency of migraine headaches...
March 2018: Electronic Physician
https://www.readbyqxmd.com/read/29764643/exploring-an-integrated-curriculum-in-pharmacy-educators-perspectives
#15
Andrew Mawdsley, Sarah Willis
BACKGROUND AND PURPOSE: Lack of consensus regarding the benefits of an integrated curriculum, and ambiguity concerning what is being integrated within a pharmacy curriculum exists, but how an integrated curriculum is viewed, epistemologically, and subsequently incorporated into teaching practice has not been investigated. This study explores how educators conceptualize, experience and enact curricula integration both pedagogically and organizationally. EDUCATIONAL ACTIVITY AND SETTING: In-depth qualitative interviews with faculty members purposively sampled for maximum variation in disciplinary background and teaching experience were undertaken at a single site...
March 2018: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29760016/diabetes-induced-cardiomyocyte-passive-stiffening-is-caused-by-impaired-insulin-dependent-titin-modification-and-can-be-modulated-by-neuregulin-1
#16
Anna-Eliane Hopf, Christian Andresen, Sebastian Kötter, Malgorzata Isic, Kamila Ulrich, Senem Sahin, Sabine Bongardt, Wilhelm Roell, Felicitas Drove, Nina Scheerer, Leni Vandekerckhove, Gilles W De Keulenaer, Nazha Hamdani, Wolfgang A Linke, Martina Krüger
<u>Rationale:</u> Increased titin-dependent cardiomyocyte tension is a hallmark of heart failure with preserved ejection fraction (HFpEF) associated with type-2 diabetes mellitus (T2DM). However, the insulin-related signaling pathways that modify titin-based cardiomyocyte tension, thereby contributing to modulation of diastolic function, are largely unknown. <u>Objective:</u> We aimed to determine how impaired insulin signaling affects titin expression and phosphorylation and thus increases passive cardiomyocyte tension, and whether metformin or neuregulin-1 can correct disturbed titin modifications and increased titin-based stiffness...
May 14, 2018: Circulation Research
https://www.readbyqxmd.com/read/29758983/intertwining-roles-of-the-disperse-phase-properties-during-emulsification
#17
Nelmary Roas-Escalona, Yhan Williams, Eliandreina Cruz-Barrios, Jhoan Toro-Mendoza
The combined effect of viscosity ratio, interfacial tension, and disperse phase density on the process of droplet formation during emulsification was evaluated. For that aim, emulsification by ultrasonication of oil/water systems with viscosity ratios between 1 and 600, with and without surfactant were performed. The time evolution of the average droplet size was estimated by dynamic light scattering measurements. For viscosity ratios between 1 and 200 in presence of surfactant, our results partly reproduce those of the intriguing U-type reported in the literature...
May 14, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29757101/identifying-and-predicting-profiles-of-medical-noncompliance-pediatric-caregivers-antibiotic-stewardship
#18
Rachel A Smith, Youllee Kim, Nkuchia M M'Ikanatha
Sometimes compliance with medical recommendations is problematic. We investigated pediatric caregivers' (N = 606) patterns of noncompliance with antibiotic stewardship based on the obstacle hypothesis. We tested predictors of noncompliance framed by the obstacle hypothesis, dissonance theory, and psychological reactance. The results revealed four profiles of caregivers' stewardship: one marked by compliance (Stewards) and three marked by types of noncompliance (Stockers, Persuaders, and Dissenters). The covariate analysis showed that, although psychological reactance predicted being noncompliant, it was types of obstacles and discrepant experiences that predicted caregivers' patterns of noncompliance with antibiotic stewardship...
May 14, 2018: Journal of Health Communication
https://www.readbyqxmd.com/read/29756528/stuttering-frequency-speech-rate-speech-naturalness-and-speech-effort-during-the-production-of-voluntary-stuttering
#19
Jason H Davidow, Heather L Grossman, Robin L Edge
PURPOSE: Voluntary stuttering techniques involve persons who stutter purposefully interjecting disfluencies into their speech. Little research has been conducted on the impact of these techniques on the speech pattern of persons who stutter. The present study examined whether changes in the frequency of voluntary stuttering accompanied changes in stuttering frequency, articulation rate, speech naturalness, and speech effort. METHOD: In total, 12 persons who stutter aged 16-34 years participated...
May 1, 2018: Language and Speech
https://www.readbyqxmd.com/read/29754946/comparison-of-interfacial-behavior-and-silver-extraction-kinetics-with-various-types-calix-4-arene-derivatives-at-heterogeneous-liquid-liquid-interfaces
#20
Jee Young Kim, Shintaro Morisada, Hidetaka Kawakita, Keisuke Ohto
Various p-tert-octylcalix[4]arene derivatives as hydrophobic extractants have been prepared to investigate Ag(I) extraction efficiency in a batch-wise process in nitric acid media. The influence of the functional groups of the hydrophobic extractants on the interfacial behavior and Ag(I) extraction efficiency in nitric acid media has been investigated using the drop-volume method. Fitting of the interfacial tension isotherms to the Gibbs and Szyszkowski equations has provided parameters characterizing the interfacial activity of the extractants, in particular the Gibbs free energy of adsorption at the interface, the interface excess on saturation (Г∞ ) and the average area per the adsorbed extractant molecule (Amin )...
May 2, 2018: Journal of Chromatography. A
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