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Suwasin Udomkarnjananun, Natavudh Townamchai, Pajaree Chariyavilaskul, Kroonpong Iampenkhae, Krit Pongpirul, Boonchoo Sirichindakul, Kamol Panumatrassamee, Jakapat Vanichanan, Yingyos Avihingsanon, Somchai Eiam-Ong, Kearkiat Praditpornsilpa
BACKGROUND: Tacrolimus is mainly metabolized by cytochrome P450 3A5 (CYP3A5), which is expressed in the liver. However, CYP3A5 is also expressed in the kidney tissue and may contribute to local tacrolimus clearance in the kidney allograft. We aimed to evaluate the association between the allograft CYP3A5 genotype and transplant outcomes. METHODS: We conducted a retrospective cohort study at the King Chulalongkorn Memorial Hospital, Thailand, comparing 2 groups of donor and recipient CYP3A5 genotypes, the expressor (*1/*1 and *1/*3) and the non-expressor (*3/*3)...
2018: American Journal of Nephrology
Wannarat Pongpirul, Krit Pongpirul, Jintanat Ananworanich, Virat Klinbuayaem, Anchalee Avihingsanon, Wisit Prasithsirikul
OBJECTIVES: As data on chronic kidney disease (CKD) incidence among Asian HIV patients has been limited, the present study aimed to estimate the CKD incidence in HIV-infected patients who received standard antiretroviral therapy in Thailand and to compare baseline demographics and clinical characteristics of the patients who developed CKD with those who do not. DESIGN: A multicenter, observational prospective cohort of HIV patients with normal kidney functions who received standard antiretroviral therapy...
January 28, 2018: AIDS
Prayuth Tunsuriyawong, Krit Pongpirul, Tagann Chaisam, Petpring Prajuabpansri
An 18-year-old Caucasian man presented with a lack of sense of surrounding smell. The problem was first noticed when a family member discussed the smell of the food, which he had no idea what it was. The patient had normal development and sexual function, no history of trauma, surgery, chemical exposure or infection. Physical examination revealed no significant abnormalities. Smell threshold test using phenyl-ethyl-alcohol revealed bilateral anosmia. MRI showed bilateral aplastic olfactory bulbs and tracts associated with absent cortical growth of the olfactory sulci and asymmetrical gyrus rectus...
October 11, 2017: BMJ Case Reports
Areeya Jirathananuwat, Krit Pongpirul
BACKGROUND: This study was aimed (1) to compare the level of physical activity (PA) between working and nonworking hours and (2) to compare the level of PA during working hours of nurse clinical practitioners (NCPs) with that of nurse managers (NMs). METHODS: This cross-sectional survey was conducted at a Thai university hospital from October 2015 to March 2016. All randomly selected participants wore an activity tracker on their hip for 5 days, except during bathing and sleeping periods, to record step counts and time points...
November 1, 2017: Journal of Physical Activity & Health
Pongsakorn Buraphat, Wannarat Pongpirul, Patama Suttha
No abstract text is available yet for this article.
June 24, 2017: BMJ Case Reports
Teerayuth Jiamjariyapon, Atiporn Ingsathit, Krit Pongpirul, Kotcharat Vipattawat, Suphattra Kanchanakorn, Akhathai Saetie, Duangjit Kanistanon, Patimaporn Wongprompitak, Vinai Leesmidt, Watcharapong Watcharasaksilp, Wei Wang, Anil K Chandraker, Kriang Tungsanga
BACKGROUND: In developing countries, renal specialists are scarce and physician-to-patient contact time is limited. While conventional hospital-based, physician-oriented approach has been the main focus of chronic kidney disease (CKD) care, a comprehensive multidisciplinary health care program (Integrated CKD Care) has been introduced as an alternate intervention to delay CKD progression in a community population. The main objective is to assess effectiveness of Integrated CKD Care in delaying CKD progression...
March 2, 2017: BMC Nephrology
Orapin Tanapanpanit, Samornmas Kanngurn, Krit Pongpirul
No abstract text is available yet for this article.
December 19, 2016: BMJ Case Reports
Wannarat Pongpirul, Wiwat Chancharoenthana, Krit Pongpirul, Asada Leelahavanichkul, Wipawee Kittikowit, Kamonwan Jutivorakool, Bunthoon Nonthasoot, Yingyos Avihingsanon, Somchai Eiam-Ong, Kearkiat Praditpornsilpa, Natavudh Townamchai
AIM: Donor-specific antibody (DSA) is a widely-used biomarker for antibody-mediated rejection (ABMR) but correctly indicates only 30-40% of patients with ABMR. Additional biomarkers of ABMR in kidney transplant recipients are needed. METHODS: All 68 kidney transplanted-recipients enrolled in this study were negative for graft rejection as determined by surveillance-biopsy ELISA at day 7 post-transplantation. Allograft biopsy was then performed at 6 months post-transplantation for subclinical-ABMR detection...
February 2018: Nephrology
Talerngsak Kanjanabuch, Nuttha Lumlertgul, Lachlan J Pearson, Tanittha Chatsuwan, Krit Pongpirul, Asada Leelahavanichkul, Nisa Thongbor, Gunticha Nuntawong, Laksamon Praderm, Pantiwa Wechagama, Surapong Narenpitak, Apinya Wechpradit, Worauma Punya, Guttiga Halue, Phetpailin Naka, Somboon Jeenapongsa, Somchai Eiam-Ong
♦ BACKGROUND: Melioidosis, an infectious disease caused by Burkholderia pseudomallei , is endemic in Southeast Asia and Northern Australia. Although a wide range of clinical manifestations from this organism are known, peritonitis associated with peritoneal dialysis (PD) has rarely been reported. ♦ PATIENTS AND METHODS: Peritoneal dialysis patients from all regions in Thailand were eligible for the study if they had peritonitis and either peritoneal fluid or effluent culture positive for B. pseudomallei ...
March 2017: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
Vibhakorn Permpoon, Krit Pongpirul, Sinn Anuras
AIM: To investigate the clinical characteristics, treatment, medication use, and treatment response in patients with ulcerative colitis (UC) across ethnic groups. METHODS: This study retrospectively analyzed medical records of all 268465 patients who visited the Bumrungrad International Digestive Disease Center during 2005-2010. The demographics, clinical characteristics, medication use, results of investigations, and medical and surgical management for patients with UC were evaluated...
August 6, 2016: World Journal of Gastrointestinal Pharmacology and Therapeutics
Bharkbhum Khambhiphant, Suganlaya Sasiwilasagorn, Nattida Chatbunchachai, Krit Pongpirul
PURPOSE: The purpose of this study was to evaluate the effect of pupillary dilation on the Haigis formula-calculated intraocular lens (IOL) power and ocular biometry measurements by using IOLMaster(®). METHODS: A prospective study was performed for biometry measurements of 373 eyes of 192 healthy subjects using the IOLMaster at the outpatient department of King Chulalongkorn Memorial Hospital from February 2013 to July 2013. The axial length (AL), anterior chamber depth (ACD), keratometry (K), and IOL power were measured before and after 1% tropicamide eye drop instillation...
2016: Clinical Ophthalmology
Asada Leelahavanichkul, Krit Pongpirul, Nisa Thongbor, Navaporn Worasilchai, Kwanta Petphuak, Bussakorn Thongsawang, Piyaporn Towannang, Pichet Lorvinitnun, Kanya Sukhontasing, Pisut Katavetin, Kearkiat Praditpornsilpa, Somchai Eiam-Ong, Ariya Chindamporn, Talerngsak Kanjanabuch
UNLABELLED:BACKGROUND: Aseptic, sheet-like foreign bodies observed inside Tenckhoff (TK) catheter lumens (referred to as "black particles") are, on gross morphology, hardly distinguishable from fungal colonization because these contaminants adhere tightly to the catheter. Detection of fungal cell wall components using (1→3)-β-d-glucan (BG) and galactomannan index (GMI) might be an alternative method for differentiating the particles. ♦ METHODS: Foreign particles retrieved from TK catheters in 19 peritoneal dialysis patients were examined microscopically and cultured for fungi and bacteria...
July 2016: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
Orapin Tanapanpanit, Krit Pongpirul
No abstract text is available yet for this article.
September 17, 2015: BMJ Case Reports
Sasitorn Siritho, Wadchara Pumpradit, Wiboon Suriyajakryuththana, Krit Pongpirul
A 43-year-old female presented with severe sharp stabbing right-sided periorbital and retroorbital area headache, dull-aching unilateral jaw pain, eyelid swelling, ptosis, and tearing of the right eye but no rash. The pain episodes lasted five minutes to one hour and occurred 10-15 times per day with unremitting milder pain between the attacks. She later developed an erythematous maculopapular rash over the right forehead and therefore was treated with antivirals. MRI performed one month after the onset revealed small hypersignal-T2 in the right dorsolateral mid-pons and from the right dorsolateral aspect of the pontomedullary region to the right dorsolateral aspect of the upper cervical cord, along the course of the principal sensory nucleus and spinal nucleus of the right trigeminal nerve...
2015: Case Reports in Radiology
Chayanut Suwanpen, Phonethipsavanh Nouanthong, Veeravich Jaruvongvanich, Krit Pongpirul, Wannarat Amornnimit Pongpirul, Asada Leelahavanichkul, Talerngsak Kanjanabuch
BACKGROUND: The prevalence of obesity is increasing during the past decade along with obesity-related glomerulopathy (ORG), glomeruli injury due to the obesity. The major pathogenesis of ORG is the shedding of podocytes from the glomerular cell barrier into urine. Podocalyxin (PCX), a main surface antigen of podocyte, correlates well with glomerulosclerosis progression and glomerular injury severity, and might be a potential biomarker for early renal alteration in obesity. In addition, vascular endothelial growth factor (VEGF) and alpha-smooth muscle actin (α-SMA) also play a role in promoting glomerulosclerosis...
February 2016: Journal of Nephrology
Mano Maneechay, Krit Pongpirul
BACKGROUND: Co-operation among staff of local government agencies is essential for good local health services system, especially in small communities. This study aims to explore possible informal relationship patterns among staff of local health and non-health organizations in the context of health decentralization in Thailand. METHODS: Tambon Health Promoting Hospital (THPH) and Sub-district Administrative Organization (SAO) represented local health and non-health organizations, respectively...
2015: BMC Health Services Research
Umamon Puangthong, Krit Pongpirul
A 25-year-old Thai woman with ovarian germ cell tumour presented with behavioural changes after receiving an intensive dose of neoadjuvant chemotherapy with bleomycin, etoposide and cisplatin, for a relapse. Her initial symptoms of mood fluctuation and insomnia were noticed while hospitalised for the third cycle, and became more severe. She was very irritable, highly distracted and forgetful. She exhibited flights of ideas and hyperactivity, including compulsive shopping. She also had paranoid ideations, auditory hallucinations, and thoughts of being wealthy and close to the prime minister...
April 9, 2015: BMJ Case Reports
Bharkbhum Khambhiphant, Nattida Chatbunchachai, Krit Pongpirul
The aim of this study is to assess the agreement of IOL power and ocular biometry measurements before and after pupillary dilatation by using the IOLMaster. This was the prospective nonrandomized cohort study. Measurements were taken with the IOLMaster (®) (Carl Zeiss Meditec AG, Jena, Germany) from healthy volunteers at the Department of Ophthalmology, King Chulalongkorn Memorial Hospital. Axial length (AL), keratometry both flattest and steepest (K1, K2), and anterior chamber depth (ACD) were measured before and after the dilatation of the pupil with 1 % tropicamide...
December 2015: International Ophthalmology
W Chancharoenthana, N Townamchai, K Pongpirul, P Kittiskulnam, A Leelahavanichkul, Y Avihingsanon, C Suankratay, S Wattanatorn, W Kittikowit, K Praditpornsilpa, K Tungsanga, S Eiam-Ong
The outcomes of kidney transplantation (KT) from hepatitis B surface antigen-positive [HBsAg(+)] donors to HBsAg(-) recipients remain inconclusive, possibly due to substantial differences in methodological and statistical models, number of patients, follow-up duration, hepatitis B virus (HBV) prophylactic regimens and hepatitis B surface antibody (anti-HBs) levels. The present retrospective, longitudinal study ( NCT02044588) using propensity score matching technique was conducted to compare outcomes of KT between HBsAg(-) recipients with anti-HBs titer above 100 mIU/mL undergoing KT from HBsAg(+) donors (n = 43) and HBsAg(-) donors (n = 86)...
December 2014: American Journal of Transplantation
Jathurong Kittrakulrat, Witthawin Jongjatuporn, Ravipol Jurjai, Nicha Jarupanich, Krit Pongpirul
BACKGROUND: In the regional movement toward ASEAN Economic Community (AEC), medical professions including physicians can be qualified to practice medicine in another country. Ensuring comparable, excellent medical qualification systems is crucial but the availability and analysis of relevant information has been lacking. OBJECTIVE: This study had the following aims: 1) to comparatively analyze information on Medical Licensing Examinations (MLE) across ASEAN countries and 2) to assess stakeholders' view on potential consequences of AEC on the medical profession from a Thai perspective...
2014: Global Health Action
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