keyword
https://read.qxmd.com/read/38622068/optimal-risk-management-considering-environmental-and-climatic-changes
#21
JOURNAL ARTICLE
Ramzi Benkraiem, Youssef El-Khatib, Jun Fan, Stéphane Goutte, Tony Klein
Climate change presents challenges to policy and economic stability, necessitating effective trading strategies to reduce environmental risks. This article addresses gaps in existing studies by using a Markov-switching model to consider climate risk. Backward stochastic differential equations are used to optimize utility with three hedging strategies based on the concept of risk aversion. Numerical scenarios confirm the model's superiority in incorporating exogenous events, with our risk-averse strategy outperforming classical approaches...
April 15, 2024: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://read.qxmd.com/read/38621430/changes-in-bone-mineral-density-in-patients-with-non-dialysis-dependent-chronic-kidney-disease-are-associated-with-body-composition
#22
JOURNAL ARTICLE
Julia Montenegro, Márcia Regina Simas Torres Klein, Carla M Prado, Maria Inês Barreto Silva
OBJECTIVE: Chronic kidney disease (CKD) and low bone mineral density (BMD) are highly prevalent and can co-exist. Parameters of mineral metabolism are associated with BMD in CKD, but other contributing factors may contribute. The aim of this study was to assess changes in BMD and its determinants in patients with non-dialysis-dependent CKD (NDD-CKD). METHODS: Body composition and biochemical profiles were assessed in a retrospective hospital-based cohort study of patients with NDD-CKD...
April 13, 2024: Journal of Renal Nutrition
https://read.qxmd.com/read/38621225/kleine-levin-syndrome-in-a-closed-psychiatric-ward-a-case-of-misdiagnosis
#23
JOURNAL ARTICLE
Mohannad Owiwi, Daniel Argo
No abstract text is available yet for this article.
April 9, 2024: Primary Care Companion to CNS Disorders
https://read.qxmd.com/read/38621200/optimized-cytogenetic-risk-group-stratification-of-kmt2a-rearranged-pediatric-acute-myeloid-leukemia
#24
JOURNAL ARTICLE
Romy Elise van Weelderen, Christine J Harrison, Kim Klein, Yilin Jiang, Jonas Abrahamsson, Todd Alonzo, Richard Aplenc, Nira Arad-Cohen, Emmanuelle Bart-Delabesse, Barbara Buldini, Barbara De Moerloose, Michael N Dworzak, Sarah Elitzur, José M Fernández Navarro, Alan S Gamis, Robert B Gerbing, Bianca F Goemans, Hester A de Groot-Kruseman, Erin M Guest, Shau Yin Ha, Henrik Hasle, Charikleia Kelaidi, Helene Lapillonne, Guy Leverger, Franco Locatelli, Takako Miyamura, Ulrika Noren-Nystrom, Sophia Polychronopoulou, Mareike Rasche, Jeffrey E Rubnitz, Jan Stary, Anne Tierens, Daisuke Tomizawa, Michel C Zwaan, Gertjan J L Kaspers
Comprehensive international consensus on cytogenetic risk-group stratification of KMT2A-rearranged (KMT2A-r) pediatric acute myeloid leukemia (AML) is lacking. This retrospective (2005-2016) International Berlin-Frankfurt-Münster Study Group study on 1,256 children with KMT2A-r AML aimed to validate the prognostic value of established recurring KMT2A fusions and additional cytogenetic aberrations (ACAs), and secondly, to define additional, recurring KMT2A fusions and ACAs, evaluating their prognostic relevance...
April 15, 2024: Blood Advances
https://read.qxmd.com/read/38619717/effect-of-vertical-stopcock-position-on-start-up-fluid-delivery-in-syringe-pumps-used-for-microinfusions
#25
JOURNAL ARTICLE
Markus Weiss, Pedro David Wendel-Garcia, Beate Grass, Maren Kleine-Brueggeney
The purpose of this in vitro study was to evaluate the impact of the vertical level of the stopcock connecting the infusion line to the central venous catheter on start-up fluid delivery in microinfusions. Start-up fluid delivery was measured under standardized conditions with the syringe outlet and liquid flow sensors positioned at heart level (0 cm) and exposed to a simulated CVP of 10 mmHg at a set flow rate of 1 ml/h. Flow and intraluminal pressures were measured with the infusion line connected to the stopcock primarily placed at vertical levels of 0 cm, + 30 cm and - 30 cm or primarily placed at 0 cm and secondarily, after connecting the infusion line, displaced to + 30 cm and - 30 cm...
April 15, 2024: Journal of Clinical Monitoring and Computing
https://read.qxmd.com/read/38618884/genetic-variants-of-unknown-significance-in-alpha-galactosidase-a-cellular-delineation-from-fabry-disease
#26
JOURNAL ARTICLE
Alexandra Klein, Katharina Klug, Maximilian Breyer, Julia Grüner, Vijay Krishna Medala, Peter Nordbeck, Christoph Wanner, Eva Klopocki, Nurcan Üçeyler
Fabry disease (FD) is an X-linked multiorgan disorder caused by variants in the alpha-galactosidase A gene (GLA). Depending on the variant, disease phenotypes range from benign to life-threatening. More than 1000 GLA variants are known, but a link between genotype and phenotype in FD has not yet been established for all. p.A143T, p.D313Y, and p.S126G are frequent examples of variants of unknown significance (VUS). We have investigated the potential pathogenicity of these VUS combining clinical data with data obtained in human cellular in vitro systems...
April 15, 2024: Journal of Inherited Metabolic Disease
https://read.qxmd.com/read/38618862/timing-of-onset-of-menses-after-gnrh-agonist-treatment-for-central-precocious-puberty
#27
JOURNAL ARTICLE
Karen O Klein, Marcela Vargas Trujillo, Sanja Dragnic, Stephen Van Komen, Moming Li, Peter A Lee
OBJECTIVES: To understand possible predictors of the onset of menses after gonadotropin-releasing hormone agonist treatment cessation in girls with central precocious puberty (CPP). METHODS: This exploratory post hoc analysis of a phase 3 and 4 trial of girls with CPP treated with once-monthly intramuscular leuprolide acetate examined onset of menses after treatment completion using a time-to-event analysis. Pretreatment and end-of-treatment chronologic age (CA), bone age (BA)/CA ratio, and Tanner breast stage; pretreatment menses status; and end-of-treatment BA and body mass index (BMI) were studied as potential factors influencing the onset of menses...
April 15, 2024: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://read.qxmd.com/read/38617959/novelties-in-slipped-capital-femoral-epiphysis-imaging-a-narrative-review
#28
REVIEW
R De Angelis, M P Aparisi Gomez, G Negro, S Ikhlef, G Fichera, A Bazzocchi, P Simoni
RATIONALE AND OBJECTIVES: Imaging plays a key role in Slipped Capital Femoral Epiphysis diagnosis and severity assessment. In the last two decades, signs and measurements emerged in literature showed potential to help in SCFE diagnosis and tailoring treatment. The purpose of this review is to collect and discuss new imaging signs, measurements, and techniques according to investigations published after 2000 to improve SCFE diagnosis. MATERIAL AND METHODS: The PubMed, Scopus, and Science Direct databases were used to search for relevant articles related to imaging in SCFE diagnosis from January 2000 to March 2023...
April 15, 2024: Heliyon
https://read.qxmd.com/read/38617360/apobec-shapes-tumor-evolution-and-age-at-onset-of-lung-cancer-in-smokers
#29
Tongwu Zhang, Jian Sang, Phuc H Hoang, Wei Zhao, Jennifer Rosenbaum, Kofi Ennu Johnson, Leszek J Klimczak, John McElderry, Alyssa Klein, Christopher Wirth, Erik N Bergstrom, Marcos Díaz-Gay, Raviteja Vangara, Frank Colon-Matos, Amy Hutchinson, Scott M Lawrence, Nathan Cole, Bin Zhu, Teresa M Przytycka, Jianxin Shi, Neil E Caporaso, Robert Homer, Angela C Pesatori, Dario Consonni, Marcin Imielinski, Stephen J Chanock, David C Wedge, Dmitry A Gordenin, Ludmil B Alexandrov, Reuben S Harris, Maria Teresa Landi
APOBEC enzymes are part of the innate immunity and are responsible for restricting viruses and retroelements by deaminating cytosine residues 1,2 . Most solid tumors harbor different levels of somatic mutations attributed to the off-target activities of APOBEC3A (A3A) and/or APOBEC3B (A3B) 3-6 . However, how APOBEC3A/B enzymes shape the tumor evolution in the presence of exogenous mutagenic processes is largely unknown. Here, by combining deep whole-genome sequencing with multi-omics profiling of 309 lung cancers from smokers with detailed tobacco smoking information, we identify two subtypes defined by low ( LAS ) and high ( HAS ) APOBEC mutagenesis...
April 3, 2024: bioRxiv
https://read.qxmd.com/read/38616406/stability-of-mosaic-divergent-repeat-interruptions-in-x-linked-dystonia-parkinsonism
#30
JOURNAL ARTICLE
Joshua Laß, Theresa Lüth, Kathleen Schlüter, Susen Schaake, Björn-Hergen Laabs, Christoph Much, Roland Dominic Jamora, Raymond L Rosales, Gerard Saranza, Cid Czarina E Diesta, Christopher E Pearson, Inke R König, Norbert Brüggemann, Christine Klein, Ana Westenberger, Joanne Trinh
BACKGROUND: X-Linked dystonia-parkinsonism (XDP) is an adult-onset neurodegenerative disorder characterized by rapidly progressive dystonia and parkinsonism. Mosaic Divergent Repeat Interruptions affecting motif Length and Sequence (mDRILS) were recently found within the TAF1 SVA repeat tract and were shown to associate with repeat stability and age at onset in XDP, specifically the AGGG [5'-SINE-VNTR-Alu(AGAGGG)2 AGGG(AGAGGG)n ] mDRILS. OBJECTIVE: This study aimed to investigate the stability of mDRILS frequencies and stability of (AGAGGG)n repeat length during transmission in parent-offspring pairs...
April 14, 2024: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/38616213/the-importance-of-practicing-at-home-during-and-following-cognitive-behavioral-therapy-for-childhood-anxiety-disorders-a-conceptual-review-and-new-directions-to-enhance-homework-using-mhealth-technology
#31
JOURNAL ARTICLE
Anke M Klein, Annelieke Hagen, Lynn Mobach, Robin Zimmermann, Jeanine M D Baartmans, Jasmin Rahemenia, Erwin de Gier, Silvia Schneider, Thomas H Ollendick
Practicing newly acquired skills in different contexts is considered a crucial aspect of Cognitive Behavioral Therapy (CBT) for anxiety disorders (Peris et al. J Am Acad Child Adolesc Psychiatry 56:1043-1052, 2017; Stewart et al. Prof Psychol Res Pract 47:303-311, 2016). Learning to cope with feared stimuli in different situations allows for generalization of learned skills, and experiencing non-occurrence of the feared outcome helps in developing non-catastrophic associations that may enhance treatment outcomes (Bandarian-Balooch et al...
April 14, 2024: Clinical Child and Family Psychology Review
https://read.qxmd.com/read/38615449/dose-dependent-effects-of-enteral-nutrition-on-the-faecal-microbiota-and-short-chain-fatty-acids
#32
JOURNAL ARTICLE
Aleksandra Jatkowska, Konstantinos Gkikas, Ben Nichols, Bryn Short, Vasiliki-Konstantina Rizou, Panagiotis Kapranos, Jennifer Klein Gunnewiek, Edelyn Christina, Vaios Svolos, Christopher Quince, Konstantinos Gerasimidis
INTRODUCTION: Enteral nutrition (EN) involves replacing all or part of a person's habitual diet with a nutritional formula. The impact of varying doses of EN on the gut microbiome remains understudied. METHODS: Healthy adults replaced all (100% EN) or part (85% EN, 50% EN and 20% EN) of their energy requirements with EN for 7 days. Faecal samples were collected before and on day 7 of interventions. Faecal pH, short chain fatty acids (SCFAs), branched-chain fatty acids (BCFAs) and 16S rRNA sequencing were performed...
April 9, 2024: Clinical Nutrition
https://read.qxmd.com/read/38614635/cooperation-for-malaria-control-and-elimination-in-the-guiana-shield
#33
REVIEW
Alice Sanna, Martha Suárez-Mutis, Yann Lambert, Luisiane Carvalho, Hedley Cairo, Horace Cox, Clara de Bort, Margarete Gomes do Socorro Mendonça, David A Forero-Peña, Juan Carlos Gabaldón-Figueira, Maria Eugenia Grillet, François Klein, Clément Lazarus, Yassamine Lazrek, Jaime Louzada, Dorinaldo Malafaia, Paola Marchesini, Lise Musset, Joseli Oliveira-Ferreira, Cassio Peterka, Cyril Rousseau, Emmanuel Roux, Leopoldo Villegas, Stephen Vreden, Solène Wiedner-Papin, Gabriel Zorello Laporta, Helene Hiwat, Maylis Douine
The Guiana Shield, a small region of South America, is currently one of the main hotspots of malaria transmission on the continent. This Amazonian area is characterised by remarkable socioeconomic, cultural, health, and political heterogeneity and a high degree of regional and cross-border population mobility, which has contributed to the increase of malaria in the region in the past few years. In this context, regional cooperation to control malaria represents both a challenge and an indispensable initiative...
May 2024: Lancet Global Health
https://read.qxmd.com/read/38614162/external-validation-of-the-si-2-ncal-2-c-score-for-outcomes-following-cerebral-venous-thrombosis
#34
JOURNAL ARTICLE
Piers Klein, Liqi Shu, Erik Lindgren, Maria A de Winter, James E Siegler, Alexis N Simpkins, Satareh Salehi Omran, Mirjam R Heldner, Adam de Havenon, Mohamad Abdalkader, Sami Al Kasab, Christoph Stretz, Teddy Y Wu, Duncan Wilson, Syed Daniyal Asad, Eyad Almallouhi, Jennifer Frontera, Lindsey Kuohn, Aaron Rothstein, Ekaterina Bakradze, Nils Henninger, Adeel S Zubair, Richa Sharma, Deborah Kerrigan, Yasmin Aziz, Eva A Mistry, Mayte Sanchez van Kammen, Turgut Tatlisumak, Katarzyna Krzywicka, Diana Aguiar de Sousa, Katarina Jood, Thalia S Field, Shadi Yaghi, Jonathan M Coutinho, Thanh N Nguyen
OBJECTIVES: Prognostication for cerebral venous thrombosis (CVT) remains difficult. We sought to validate the SI2 NCAL2 C score in an international cohort. MATERIALS AND METHODS: The SI2 NCAL2 C score was originally developed to predict poor outcome (modified Rankin Scale (mRS) 3-6) at 6 months, and mortality at 30 days and 1 year using data from the International CVT Consortium. The SI2 NCAL2 C score uses 9 variables: the absence of any female-sex-specific risk factors, intracerebral hemorrhage, central nervous system infection, focal neurological deficits, coma, age, lower level of hemoglobin, higher level of glucose, and cancer...
April 11, 2024: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://read.qxmd.com/read/38613913/results-from-the-united-study-a-multicenter-study-validating-the-prognostic-effect-of-the-tumor-stroma-ratio-in-colon-cancer
#35
JOURNAL ARTICLE
M Polack, M A Smit, G W van Pelt, A G H Roodvoets, E Meershoek-Klein Kranenbarg, H Putter, H Gelderblom, A S L P Crobach, V Terpstra, G Petrushevska, G Gašljević, S Kjær-Frifeldt, E M V de Cuba, N W J Bulkmans, G R Vink, R Al Dieri, R A E M Tollenaar, J H J M van Krieken, W E Mesker
BACKGROUND: The TNM (tumor-node-metastasis) Evaluation Committee of Union for International Cancer Control (UICC) and College of American Pathologists (CAP) recommended to prospectively validate the cost-effective and robust tumor-stroma ratio (TSR) as an independent prognostic parameter, since high intratumor stromal percentages have previously predicted poor patient-related outcomes. PATIENTS AND METHODS: The 'Uniform Noting for International application of Tumor-stroma ratio as Easy Diagnostic tool' (UNITED) study enrolled patients in 27 participating centers in 12 countries worldwide...
April 12, 2024: ESMO Open
https://read.qxmd.com/read/38613283/study-of-high-transverse-momentum-higgs-boson-production-in-association-with-a-vector-boson-in-the-qqbb-final-state-with-the-atlas-detector
#36
JOURNAL ARTICLE
G Aad, B Abbott, K Abeling, N J Abicht, S H Abidi, A Aboulhorma, H Abramowicz, H Abreu, Y Abulaiti, B S Acharya, C Adam Bourdarios, L Adamczyk, S V Addepalli, M J Addison, J Adelman, A Adiguzel, T Adye, A A Affolder, Y Afik, M N Agaras, J Agarwala, A Aggarwal, C Agheorghiesei, A Ahmad, F Ahmadov, W S Ahmed, S Ahuja, X Ai, G Aielli, A Aikot, M Ait Tamlihat, B Aitbenchikh, I Aizenberg, M Akbiyik, T P A Åkesson, A V Akimov, D Akiyama, N N Akolkar, S Aktas, K Al Khoury, G L Alberghi, J Albert, P Albicocco, G L Albouy, S Alderweireldt, Z L Alegria, M Aleksa, I N Aleksandrov, C Alexa, T Alexopoulos, F Alfonsi, M Algren, M Alhroob, B Ali, H M J Ali, S Ali, S W Alibocus, M Aliev, G Alimonti, W Alkakhi, C Allaire, B M M Allbrooke, J F Allen, C A Allendes Flores, P P Allport, A Aloisio, F Alonso, C Alpigiani, M Alvarez Estevez, A Alvarez Fernandez, M Alves Cardoso, M G Alviggi, M Aly, Y Amaral Coutinho, A Ambler, C Amelung, M Amerl, C G Ames, D Amidei, S P Amor Dos Santos, K R Amos, V Ananiev, C Anastopoulos, T Andeen, J K Anders, S Y Andrean, A Andreazza, S Angelidakis, A Angerami, A V Anisenkov, A Annovi, C Antel, M T Anthony, E Antipov, M Antonelli, F Anulli, M Aoki, T Aoki, J A Aparisi Pozo, M A Aparo, L Aperio Bella, C Appelt, A Apyan, N Aranzabal, S J Arbiol Val, C Arcangeletti, A T H Arce, E Arena, J-F Arguin, S Argyropoulos, J-H Arling, O Arnaez, H Arnold, G Artoni, H Asada, K Asai, S Asai, N A Asbah, K Assamagan, R Astalos, S Atashi, R J Atkin, M Atkinson, H Atmani, P A Atmasiddha, K Augsten, S Auricchio, A D Auriol, V A Austrup, G Avolio, K Axiotis, G Azuelos, D Babal, H Bachacou, K Bachas, A Bachiu, F Backman, A Badea, T M Baer, P Bagnaia, M Bahmani, D Bahner, A J Bailey, V R Bailey, J T Baines, L Baines, O K Baker, E Bakos, D Bakshi Gupta, V Balakrishnan, R Balasubramanian, E M Baldin, P Balek, E Ballabene, F Balli, L M Baltes, W K Balunas, J Balz, E Banas, M Bandieramonte, A Bandyopadhyay, S Bansal, L Barak, M Barakat, E L Barberio, D Barberis, M Barbero, M Z Barel, K N Barends, T Barillari, M-S Barisits, T Barklow, P Baron, D A Baron Moreno, A Baroncelli, G Barone, A J Barr, J D Barr, L Barranco Navarro, F Barreiro, J Barreiro Guimarães da Costa, U Barron, M G Barros Teixeira, S Barsov, F Bartels, R Bartoldus, A E Barton, P Bartos, A Basan, M Baselga, A Bassalat, M J Basso, C R Basson, R L Bates, S Batlamous, J R Batley, B Batool, M Battaglia, D Battulga, M Bauce, M Bauer, P Bauer, L T Bazzano Hurrell, J B Beacham, T Beau, J Y Beaucamp, P H Beauchemin, P Bechtle, H P Beck, K Becker, A J Beddall, V A Bednyakov, C P Bee, L J Beemster, T A Beermann, M Begalli, M Begel, A Behera, J K Behr, J F Beirer, F Beisiegel, M Belfkir, G Bella, L Bellagamba, A Bellerive, P Bellos, K Beloborodov, D Benchekroun, F Bendebba, Y Benhammou, M Benoit, S Bentvelsen, L Beresford, M Beretta, E Bergeaas Kuutmann, N Berger, B Bergmann, J Beringer, G Bernardi, C Bernius, F U Bernlochner, F Bernon, A Berrocal Guardia, T Berry, P Berta, A Berthold, I A Bertram, S Bethke, A Betti, A J Bevan, N K Bhalla, M Bhamjee, S Bhatta, D S Bhattacharya, P Bhattarai, V S Bhopatkar, R Bi, R M Bianchi, G Bianco, O Biebel, R Bielski, M Biglietti, M Bindi, A Bingul, C Bini, A Biondini, C J Birch-Sykes, G A Bird, M Birman, M Biros, S Biryukov, T Bisanz, E Bisceglie, J P Biswal, D Biswas, A Bitadze, K Bjørke, I Bloch, A Blue, U Blumenschein, J Blumenthal, G J Bobbink, V S Bobrovnikov, M Boehler, B Boehm, D Bogavac, A G Bogdanchikov, C Bohm, V Boisvert, P Bokan, T Bold, M Bomben, M Bona, M Boonekamp, C D Booth, A G Borbély, I S Bordulev, H M Borecka-Bielska, G Borissov, D Bortoletto, D Boscherini, M Bosman, J D Bossio Sola, K Bouaouda, N Bouchhar, J Boudreau, E V Bouhova-Thacker, D Boumediene, R Bouquet, A Boveia, J Boyd, D Boye, I R Boyko, J Bracinik, N Brahimi, G Brandt, O Brandt, F Braren, B Brau, J E Brau, R Brener, L Brenner, R Brenner, S Bressler, D Britton, D Britzger, I Brock, G Brooijmans, W K Brooks, E Brost, L M Brown, L E Bruce, T L Bruckler, P A Bruckman de Renstrom, B Brüers, A Bruni, G Bruni, M Bruschi, N Bruscino, T Buanes, Q Buat, D Buchin, A G Buckley, O Bulekov, B A Bullard, S Burdin, C D Burgard, A M Burger, B Burghgrave, O Burlayenko, J T P Burr, C D Burton, J C Burzynski, E L Busch, V Büscher, P J Bussey, J M Butler, C M Buttar, J M Butterworth, W Buttinger, C J Buxo Vazquez, A R Buzykaev, S Cabrera Urbán, L Cadamuro, D Caforio, H Cai, Y Cai, Y Cai, V M M Cairo, O Cakir, N Calace, P Calafiura, G Calderini, P Calfayan, G Callea, L P Caloba, D Calvet, S Calvet, M Calvetti, R Camacho Toro, S Camarda, D Camarero Munoz, P Camarri, M T Camerlingo, D Cameron, C Camincher, M Campanelli, A Camplani, V Canale, A Canesse, J Cantero, Y Cao, F Capocasa, M Capua, A Carbone, R Cardarelli, J C J Cardenas, F Cardillo, G Carducci, T Carli, G Carlino, J I Carlotto, B T Carlson, E M Carlson, L Carminati, A Carnelli, M Carnesale, S Caron, E Carquin, S Carrá, G Carratta, F Carrio Argos, J W S Carter, T M Carter, M P Casado, M Caspar, F L Castillo, L Castillo Garcia, V Castillo Gimenez, N F Castro, A Catinaccio, J R Catmore, V Cavaliere, N Cavalli, V Cavasinni, Y C Cekmecelioglu, E Celebi, F Celli, M S Centonze, V Cepaitis, K Cerny, A S Cerqueira, A Cerri, L Cerrito, F Cerutti, B Cervato, A Cervelli, G Cesarini, S A Cetin, D Chakraborty, J Chan, W Y Chan, J D Chapman, E Chapon, B Chargeishvili, D G Charlton, M Chatterjee, C Chauhan, S Chekanov, S V Chekulaev, G A Chelkov, A Chen, B Chen, B Chen, H Chen, H Chen, J Chen, J Chen, M Chen, S Chen, S J Chen, X Chen, X Chen, Y Chen, C L Cheng, H C Cheng, S Cheong, A Cheplakov, E Cheremushkina, E Cherepanova, R Cherkaoui El Moursli, E Cheu, K Cheung, L Chevalier, V Chiarella, G Chiarelli, N Chiedde, G Chiodini, A S Chisholm, A Chitan, M Chitishvili, M V Chizhov, K Choi, A R Chomont, Y Chou, E Y S Chow, T Chowdhury, K L Chu, M C Chu, X Chu, J Chudoba, J J Chwastowski, D Cieri, K M Ciesla, V Cindro, A Ciocio, F Cirotto, Z H Citron, M Citterio, D A Ciubotaru, A Clark, P J Clark, C Clarry, J M Clavijo Columbie, S E Clawson, C Clement, J Clercx, Y Coadou, M Cobal, A Coccaro, R F Coelho Barrue, R Coelho Lopes De Sa, S Coelli, A E C Coimbra, B Cole, J Collot, P Conde Muiño, M P Connell, S H Connell, I A Connelly, E I Conroy, F Conventi, H G Cooke, A M Cooper-Sarkar, A Cordeiro Oudot Choi, L D Corpe, M Corradi, F Corriveau, A Cortes-Gonzalez, M J Costa, F Costanza, D Costanzo, B M Cote, G Cowan, K Cranmer, D Cremonini, S Crépé-Renaudin, F Crescioli, M Cristinziani, M Cristoforetti, V Croft, J E Crosby, G Crosetti, A Cueto, T Cuhadar Donszelmann, H Cui, Z Cui, W R Cunningham, F Curcio, P Czodrowski, M M Czurylo, M J Da Cunha Sargedas De Sousa, J V Da Fonseca Pinto, C Da Via, W Dabrowski, T Dado, S Dahbi, T Dai, D Dal Santo, C Dallapiccola, M Dam, G D'amen, V D'Amico, J Damp, J R Dandoy, M Danninger, V Dao, G Darbo, S Darmora, S J Das, S D'Auria, C David, T Davidek, B Davis-Purcell, I Dawson, H A Day-Hall, K De, R De Asmundis, N De Biase, S De Castro, N De Groot, P de Jong, H De la Torre, A De Maria, A De Salvo, U De Sanctis, F De Santis, A De Santo, J B De Vivie De Regie, D V Dedovich, J Degens, A M Deiana, F Del Corso, J Del Peso, F Del Rio, L Delagrange, F Deliot, C M Delitzsch, M Della Pietra, D Della Volpe, A Dell'Acqua, L Dell'Asta, M Delmastro, P A Delsart, S Demers, M Demichev, S P Denisov, L D'Eramo, D Derendarz, F Derue, P Dervan, K Desch, C Deutsch, F A Di Bello, A Di Ciaccio, L Di Ciaccio, A Di Domenico, C Di Donato, A Di Girolamo, G Di Gregorio, A Di Luca, B Di Micco, R Di Nardo, C Diaconu, M Diamantopoulou, F A Dias, T Dias Do Vale, M A Diaz, F G Diaz Capriles, M Didenko, E B Diehl, L Diehl, S Díez Cornell, C Diez Pardos, C Dimitriadi, A Dimitrievska, J Dingfelder, I-M Dinu, S J Dittmeier, F Dittus, F Djama, T Djobava, C Doglioni, A Dohnalova, J Dolejsi, Z Dolezal, K M Dona, M Donadelli, B Dong, J Donini, A D'Onofrio, M D'Onofrio, J Dopke, A Doria, N Dos Santos Fernandes, P Dougan, M T Dova, A T Doyle, M A Draguet, E Dreyer, I 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E Penski, M Penzin, B S Peralva, A P Pereira Peixoto, L Pereira Sanchez, D V Perepelitsa, E Perez Codina, M Perganti, H Pernegger, O Perrin, K Peters, R F Y Peters, B A Petersen, T C Petersen, E Petit, V Petousis, C Petridou, A Petrukhin, M Pettee, N E Pettersson, A Petukhov, K Petukhova, R Pezoa, L Pezzotti, G Pezzullo, T M Pham, T Pham, P W Phillips, G Piacquadio, E Pianori, F Piazza, R Piegaia, D Pietreanu, A D Pilkington, M Pinamonti, J L Pinfold, B C Pinheiro Pereira, A E Pinto Pinoargote, L Pintucci, K M Piper, A Pirttikoski, D A Pizzi, L Pizzimento, A Pizzini, M-A Pleier, V Plesanovs, V Pleskot, E Plotnikova, G Poddar, R Poettgen, L Poggioli, I Pokharel, S Polacek, G Polesello, A Poley, R Polifka, A Polini, C S Pollard, Z B Pollock, V Polychronakos, E Pompa Pacchi, D Ponomarenko, L Pontecorvo, S Popa, G A Popeneciu, A Poreba, D M Portillo Quintero, S Pospisil, M A Postill, P Postolache, K Potamianos, P A Potepa, I N Potrap, C J Potter, H Potti, T Poulsen, J Poveda, M E Pozo 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M Rimoldi, L Rinaldi, T T Rinn, M P Rinnagel, G Ripellino, I Riu, P Rivadeneira, J C Rivera Vergara, F Rizatdinova, E Rizvi, B A Roberts, B R Roberts, S H Robertson, D Robinson, C M Robles Gajardo, M Robles Manzano, A Robson, A Rocchi, C Roda, S Rodriguez Bosca, Y Rodriguez Garcia, A Rodriguez Rodriguez, A M Rodríguez Vera, S Roe, J T Roemer, A R Roepe-Gier, J Roggel, O Røhne, R A Rojas, C P A Roland, J Roloff, A Romaniouk, E Romano, M Romano, A C Romero Hernandez, N Rompotis, L Roos, S Rosati, B J Rosser, E Rossi, E Rossi, L P Rossi, L Rossini, R Rosten, M Rotaru, B Rottler, C Rougier, D Rousseau, D Rousso, A Roy, S Roy-Garand, A Rozanov, Z M A Rozario, Y Rozen, X Ruan, A Rubio Jimenez, A J Ruby, V H Ruelas Rivera, T A Ruggeri, A Ruggiero, A Ruiz-Martinez, A Rummler, Z Rurikova, N A Rusakovich, H L Russell, G Russo, J P Rutherfoord, S Rutherford Colmenares, K Rybacki, M Rybar, E B Rye, A Ryzhov, J A Sabater Iglesias, P Sabatini, H F-W Sadrozinski, F Safai Tehrani, B Safarzadeh Samani, M Safdari, S Saha, M Sahinsoy, A Saibel, M Saimpert, M Saito, T Saito, D Salamani, A Salnikov, J Salt, A Salvador Salas, D Salvatore, F Salvatore, A Salzburger, D Sammel, D Sampsonidis, D Sampsonidou, J Sánchez, A Sanchez Pineda, V Sanchez Sebastian, H Sandaker, C O Sander, J A Sandesara, M Sandhoff, C Sandoval, D P C Sankey, T Sano, A Sansoni, L Santi, C Santoni, H Santos, A Santra, K A Saoucha, J G Saraiva, J Sardain, O Sasaki, K Sato, C Sauer, F Sauerburger, E Sauvan, P Savard, R Sawada, C Sawyer, L Sawyer, I Sayago Galvan, C Sbarra, A Sbrizzi, T Scanlon, J Schaarschmidt, U Schäfer, A C Schaffer, D Schaile, R D Schamberger, C Scharf, M M Schefer, V A Schegelsky, D Scheirich, F Schenck, M Schernau, C Scheulen, C Schiavi, E J Schioppa, M Schioppa, B Schlag, K E Schleicher, S Schlenker, J Schmeing, M A Schmidt, K Schmieden, C Schmitt, N Schmitt, S Schmitt, L Schoeffel, A Schoening, P G Scholer, E Schopf, M Schott, J Schovancova, S Schramm, F Schroeder, T Schroer, H-C Schultz-Coulon, M Schumacher, B A Schumm, Ph Schune, A J Schuy, H R Schwartz, A Schwartzman, T A Schwarz, Ph Schwemling, R Schwienhorst, A Sciandra, G Sciolla, F Scuri, C D Sebastiani, K Sedlaczek, P Seema, S C Seidel, A Seiden, B D Seidlitz, C Seitz, J M Seixas, G Sekhniaidze, L Selem, N Semprini-Cesari, D Sengupta, V Senthilkumar, L Serin, L Serkin, M Sessa, H Severini, F Sforza, A Sfyrla, E Shabalina, R Shaheen, J D Shahinian, D Shaked Renous, L Y Shan, M Shapiro, A Sharma, A S Sharma, P Sharma, S Sharma, P B Shatalov, K Shaw, S M Shaw, A Shcherbakova, Q Shen, D J Sheppard, P Sherwood, L Shi, X Shi, C O Shimmin, J D Shinner, I P J Shipsey, S Shirabe, M Shiyakova, J Shlomi, M J Shochet, J Shojaii, D R Shope, B Shrestha, S Shrestha, E M Shrif, M J Shroff, P Sicho, A M Sickles, E Sideras Haddad, A Sidoti, F Siegert, Dj Sijacki, F Sili, J M Silva, M V Silva Oliveira, S B Silverstein, S Simion, R Simoniello, E L Simpson, H Simpson, L R Simpson, N D Simpson, S Simsek, S Sindhu, P Sinervo, S Singh, S Sinha, S Sinha, M Sioli, I Siral, E Sitnikova, S Yu Sivoklokov, J Sjölin, A Skaf, E Skorda, P Skubic, M Slawinska, V Smakhtin, B H Smart, S Yu Smirnov, Y Smirnov, L N Smirnova, O Smirnova, A C Smith, E A Smith, H A Smith, J L Smith, R Smith, M Smizanska, K Smolek, A A Snesarev, S R Snider, H L Snoek, S Snyder, R Sobie, A Soffer, C A Solans Sanchez, E Yu Soldatov, U Soldevila, A A Solodkov, S Solomon, A Soloshenko, K Solovieva, O V Solovyanov, V Solovyev, P Sommer, A Sonay, W Y Song, A Sopczak, A L Sopio, F Sopkova, J D Sorenson, I R Sotarriva Alvarez, V Sothilingam, O J Soto Sandoval, S Sottocornola, R Soualah, Z Soumaimi, D South, N Soybelman, S Spagnolo, M Spalla, D Sperlich, G Spigo, S Spinali, D P Spiteri, M Spousta, E J Staats, A Stabile, R Stamen, A Stampekis, M Standke, E Stanecka, M V Stange, B Stanislaus, M M Stanitzki, B Stapf, E A Starchenko, G H Stark, J Stark, P Staroba, P Starovoitov, S Stärz, R Staszewski, G Stavropoulos, J Steentoft, P Steinberg, B Stelzer, H J Stelzer, O Stelzer-Chilton, H Stenzel, T J Stevenson, G A Stewart, J R Stewart, M C Stockton, G Stoicea, M Stolarski, S Stonjek, A Straessner, J Strandberg, S Strandberg, M Stratmann, M Strauss, T Strebler, P Strizenec, R Ströhmer, D M Strom, R Stroynowski, A Strubig, S A Stucci, B Stugu, J Stupak, N A Styles, D Su, S Su, W Su, X Su, K Sugizaki, V V Sulin, M J Sullivan, D M S Sultan, L Sultanaliyeva, S Sultansoy, T Sumida, S Sun, S Sun, O Sunneborn Gudnadottir, N Sur, M R Sutton, H Suzuki, M Svatos, M Swiatlowski, T Swirski, I Sykora, M Sykora, T Sykora, D Ta, K Tackmann, A Taffard, R Tafirout, J S Tafoya Vargas, E P Takeva, Y Takubo, M Talby, A A Talyshev, K C Tam, N M Tamir, A Tanaka, J Tanaka, R Tanaka, M Tanasini, Z Tao, S Tapia Araya, S Tapprogge, A Tarek Abouelfadl Mohamed, S Tarem, K Tariq, G Tarna, G F Tartarelli, P Tas, M Tasevsky, E Tassi, A C Tate, G Tateno, Y Tayalati, G N Taylor, W Taylor, A S Tee, R Teixeira De Lima, P Teixeira-Dias, J J Teoh, K Terashi, J Terron, S Terzo, M Testa, R J Teuscher, A Thaler, O Theiner, N Themistokleous, T Theveneaux-Pelzer, O Thielmann, D W Thomas, J P Thomas, E A Thompson, P D Thompson, E Thomson, Y Tian, V Tikhomirov, Yu A Tikhonov, S Timoshenko, D Timoshyn, E X L Ting, P Tipton, S H Tlou, A Tnourji, K Todome, S Todorova-Nova, S Todt, M Togawa, J Tojo, S Tokár, K Tokushuku, O Toldaiev, R Tombs, M Tomoto, L Tompkins, K W Topolnicki, E Torrence, H Torres, E Torró Pastor, M Toscani, C Tosciri, M Tost, D R Tovey, A Traeet, I S Trandafir, T Trefzger, A Tricoli, I M Trigger, S Trincaz-Duvoid, D A Trischuk, B Trocmé, C Troncon, L Truong, M Trzebinski, A Trzupek, F Tsai, M Tsai, A Tsiamis, P V Tsiareshka, S Tsigaridas, A Tsirigotis, V Tsiskaridze, E G Tskhadadze, M Tsopoulou, Y Tsujikawa, I I Tsukerman, V Tsulaia, S Tsuno, K Tsuri, D Tsybychev, Y Tu, A Tudorache, V Tudorache, A N Tuna, S Turchikhin, I Turk Cakir, R Turra, T Turtuvshin, P M Tuts, S Tzamarias, P Tzanis, E Tzovara, F Ukegawa, P A Ulloa Poblete, E N Umaka, G Unal, M Unal, A Undrus, G Unel, J Urban, P Urquijo, P Urrejola, G Usai, R Ushioda, M Usman, Z Uysal, V Vacek, B Vachon, K O H Vadla, T Vafeiadis, A Vaitkus, C Valderanis, E Valdes Santurio, M Valente, S Valentinetti, A Valero, E Valiente Moreno, A Vallier, J A Valls Ferrer, D R Van Arneman, T R Van Daalen, A Van Der Graaf, P Van Gemmeren, M Van Rijnbach, S Van Stroud, I Van Vulpen, M Vanadia, W Vandelli, M Vandenbroucke, E R Vandewall, D Vannicola, L Vannoli, R Vari, E W Varnes, C Varni, T Varol, D Varouchas, L Varriale, K E Varvell, M E Vasile, L Vaslin, G A Vasquez, A Vasyukov, F Vazeille, T Vazquez Schroeder, J Veatch, V Vecchio, M J Veen, I Veliscek, L M Veloce, F Veloso, S Veneziano, A Ventura, S Ventura Gonzalez, A Verbytskyi, M Verducci, C Vergis, M Verissimo De Araujo, W Verkerke, J C Vermeulen, C Vernieri, M Vessella, M C Vetterli, A Vgenopoulos, N Viaux Maira, T Vickey, O E Vickey Boeriu, G H A Viehhauser, L Vigani, M Villa, M Villaplana Perez, E M Villhauer, E Vilucchi, M G Vincter, G S Virdee, A Vishwakarma, A Visibile, C Vittori, I Vivarelli, E Voevodina, F Vogel, J C Voigt, P Vokac, Yu Volkotrub, J Von Ahnen, E Von Toerne, B Vormwald, V Vorobel, K Vorobev, M Vos, K Voss, J H Vossebeld, M Vozak, L Vozdecky, N Vranjes, M Vranjes Milosavljevic, M Vreeswijk, N K Vu, R Vuillermet, O Vujinovic, I Vukotic, S Wada, C Wagner, J M Wagner, W Wagner, S Wahdan, H Wahlberg, M Wakida, J Walder, R Walker, W Walkowiak, A Wall, T Wamorkar, A Z Wang, C Wang, C Wang, H Wang, J Wang, R-J Wang, R Wang, R Wang, S M Wang, S Wang, T Wang, W T Wang, W Wang, X Wang, X Wang, X Wang, Y Wang, Y Wang, Z Wang, Z Wang, Z Wang, A Warburton, R J Ward, N Warrack, S Waterhouse, A T Watson, H Watson, M F Watson, E Watton, G Watts, B M Waugh, C Weber, H A Weber, M S Weber, S M Weber, C Wei, Y Wei, A R Weidberg, E J Weik, J Weingarten, M Weirich, C Weiser, C J Wells, T Wenaus, B Wendland, T Wengler, N S Wenke, N Wermes, M Wessels, A M Wharton, A S White, A White, M J White, D Whiteson, L Wickremasinghe, W Wiedenmann, M Wielers, C Wiglesworth, D J Wilbern, H G Wilkens, D M Williams, H H Williams, S Williams, S Willocq, B J Wilson, P J Windischhofer, F I Winkel, F Winklmeier, B T Winter, J K Winter, M Wittgen, M Wobisch, Z Wolffs, J Wollrath, M W Wolter, H Wolters, A F Wongel, E L Woodward, S D Worm, B K Wosiek, K W Woźniak, S Wozniewski, K Wraight, C Wu, J Wu, M Wu, M Wu, S L Wu, X Wu, Y Wu, Z Wu, J Wuerzinger, T R Wyatt, B M Wynne, S Xella, L Xia, M Xia, J Xiang, M Xie, X Xie, S Xin, A Xiong, J Xiong, D Xu, H Xu, L Xu, R Xu, T Xu, Y Xu, Z Xu, Z Xu, B Yabsley, S Yacoob, Y Yamaguchi, E Yamashita, H Yamauchi, T Yamazaki, Y Yamazaki, J Yan, S Yan, Z Yan, H J Yang, H T Yang, S Yang, T Yang, X Yang, X Yang, Y Yang, Y Yang, Z Yang, W-M Yao, Y C Yap, H Ye, H Ye, J Ye, S Ye, X Ye, Y Yeh, I Yeletskikh, B K Yeo, M R Yexley, P Yin, K Yorita, S Younas, C J S Young, C Young, C Yu, Y Yu, M Yuan, R Yuan, L Yue, M Zaazoua, B Zabinski, E Zaid, Z K Zak, T Zakareishvili, N Zakharchuk, S Zambito, J A Zamora Saa, J Zang, D Zanzi, O Zaplatilek, C Zeitnitz, H Zeng, J C Zeng, D T Zenger, O Zenin, T Ženiš, S Zenz, S Zerradi, D Zerwas, M Zhai, B Zhang, D F Zhang, J Zhang, J Zhang, K Zhang, L Zhang, P Zhang, R Zhang, S Zhang, S Zhang, T Zhang, X Zhang, X Zhang, Y Zhang, Y Zhang, Y Zhang, Z Zhang, Z Zhang, H Zhao, T Zhao, Y Zhao, Z Zhao, A Zhemchugov, J Zheng, K Zheng, X Zheng, Z Zheng, D Zhong, B Zhou, H Zhou, N Zhou, Y Zhou, Y Zhou, C G Zhu, J Zhu, Y Zhu, Y Zhu, X Zhuang, K Zhukov, V Zhulanov, N I Zimine, J Zinsser, M Ziolkowski, L Živković, A Zoccoli, K Zoch, T G Zorbas, O Zormpa, W Zou, L Zwalinski
This Letter presents the first study of Higgs boson production in association with a vector boson (V=W or Z) in the fully hadronic qqbb final state using data recorded by the ATLAS detector at the LHC in proton-proton collisions at sqrt[s]=13  TeV and corresponding to an integrated luminosity of 137  fb^{-1}. The vector bosons and Higgs bosons are each reconstructed as large-radius jets and tagged using jet substructure techniques. Dedicated tagging algorithms exploiting b-tagging properties are used to identify jets consistent with Higgs bosons decaying into bb[over ¯]...
March 29, 2024: Physical Review Letters
https://read.qxmd.com/read/38612795/identification-of-serum-interleukin-22-as-novel-biomarker-in-pulmonary-hypertension-a-translational-study
#37
JOURNAL ARTICLE
Friederike Klein, Sandesh Dinesh, Desiree Fiedler, Katja Grün, Andrea Schrepper, Jürgen Bogoviku, Laura Bäz, Alexander Pfeil, Daniel Kretzschmar, P Christian Schulze, Sven Möbius-Winkler, Marcus Franz
Growing evidence suggests the crucial involvement of inflammation in the pathogenesis of pulmonary hypertension (PH). The current study analyzed the expression of interleukin (IL)-17a and IL-22 as potential biomarkers for PH in a preclinical rat model of PH as well as the serum levels in a PH patient collective. PH was induced by monocrotalin (60 mg/kg body weight s.c.) in 10 Sprague Dawley rats (PH) and compared to 6 sham-treated controls (CON) as well as 10 monocrotalin-induced, macitentan-treated rats (PH_MAC)...
April 3, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38610884/comparative-analysis-of-therapeutic-strategies-in-post-cardiotomy-cardiogenic-shock-insight-into-a-high-volume-cardiac-surgery-center
#38
JOURNAL ARTICLE
B Ufuk Baldan, Romy R M J J Hegeman, Nelleke M J P Bos, Hans G Smeenk, Robert J M Klautz, Patrick Klein
Background : Post-cardiotomy cardiogenic shock (PCCS), which is defined as severe low cardiac output syndrome after cardiac surgery, has a mortality rate of up to 90%. No study has yet been performed to compare patients with PCCS treated by conservative means to patients receiving additional mechanical circulatory support with veno-arterial extracorporeal membrane oxygenation (ECMO). Methods : A single-center retrospective analysis from January 2018 to June 2022 was performed. Results : Out of 7028 patients who underwent cardiac surgery during this time period, 220 patients (3%) developed PCCS...
April 5, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38609521/understanding-familial-risk-of-pancreatic-ductal-adenocarcinoma
#39
REVIEW
Raymond M Paranal, Laura D Wood, Alison P Klein, Nicholas J Roberts
Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease that is the result of an accumulation of sequential genetic alterations. These genetic alterations can either be inherited, such as pathogenic germline variants that are associated with an increased risk of cancer, or acquired, such as somatic mutations that occur during the lifetime of an individual. Understanding the genetic basis of inherited risk of PDAC is essential to advancing patient care and outcomes through improved clinical surveillance, early detection initiatives, and targeted therapies...
April 12, 2024: Familial Cancer
https://read.qxmd.com/read/38608668/-demstepcare-risk-stratified-support-for-primary-care-based-dementia-care-evaluation-from-general-practitioner-s-view
#40
JOURNAL ARTICLE
Katharina Geschke, Julian Wangler, Fabian Klein, Alexandra Wuttke-Linnemann, Erik Farin-Glattacker, Michael Löhr, Michael Jansky, Andreas Fellgiebel
OBJECTIVE: The innovation fund project DemStepCare aimed to optimize multi-professional care through case management, risk stratification, and crisis outpatient clinic. Here, the evaluation results from the perspective of the general practitioners are presented. METHODS: A quantitative survey was carried out at three time points regarding acceptance, benefit assessment and sensitivity to dementia of the general practitioners. In addition, qualitative interviews were conducted...
April 12, 2024: Psychiatrische Praxis
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