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https://www.readbyqxmd.com/read/28225374/characterizing-the-toxicity-and-dose-effect-profile-of-tramadol-ingestions-in-children
#1
Gina L Stassinos, Lawrence Gonzales, Wendy Klein-Schwartz
OBJECTIVES: Tramadol can cause life-threatening toxicity in overdose; however, data on its toxicity in children are lacking. This study investigates toxicity associated with tramadol ingestions in children. The hypothesis is that children will experience dose-related central nervous system and respiratory depression and seizures. METHODS: A retrospective evaluation of cases from the National Poison Center Data System between January 1, 2000, and December 31, 2013, was performed...
February 21, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28223406/sex-drives-dimorphic-immune-responses-to-viral-infections
#2
REVIEW
Soumitra Ghosh, Robyn S Klein
New attention to sexual dimorphism in normal mammalian physiology and disease has uncovered a previously unappreciated breadth of mechanisms by which females and males differentially exhibit quantitative phenotypes. Thus, in addition to the established modifying effects of hormones, which prenatally and postpubertally pattern cells and tissues in a sexually dimorphic fashion, sex differences are caused by extragonadal and dosage effects of genes encoded on sex chromosomes. Sex differences in immune responses, especially during autoimmunity, have been studied predominantly within the context of sex hormone effects...
March 1, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28223187/deepnat-deep-convolutional-neural-network-for-segmenting-neuroanatomy
#3
Christian Wachinger, Martin Reuter, Tassilo Klein
We introduce DeepNAT, a 3D Deep convolutional neural network for the automatic segmentation of NeuroAnaTomy in T1-weighted magnetic resonance images. DeepNAT is an end-to-end learning-based approach to brain segmentation that jointly learns an abstract feature representation and a multi-class classification. We propose a 3D patch-based approach, where we do not only predict the center voxel of the patch but also neighbors, which is formulated as multi-task learning. To address a class imbalance problem, we arrange two networks hierarchically, where the first one separates foreground from background, and the second one identifies 25 brain structures on the foreground...
February 18, 2017: NeuroImage
https://www.readbyqxmd.com/read/28223050/tricuspid-regurgitation-associated-with%C3%A2-ischemic-mitral-regurgitation-characterization-evolution-after-mitral-surgery-and-value-of-tricuspid-repair
#4
José L Navia, Haytham Elgharably, Hoda Javadikasgari, Ahmed Ibrahim, Marijan Koprivanac, Ashley M Lowry, Eugene H Blackstone, Allan L Klein, A Marc Gillinov, Eric E Roselli, Lars G Svensson
BACKGROUND: Tricuspid regurgitation (TR) often accompanies ischemic mitral regurgitation and is generally assumed to be a secondary consequence of altered hemodynamics of the left-sided regurgitation. We hypothesized that it may also be a direct consequence of right-sided ischemic disease. Therefore, our objectives were to (1) characterize the nature of this TR and (2) describe its time course after mitral valve surgery for ischemic mitral regurgitation, with or without concomitant tricuspid valve repair...
February 18, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28221871/determination-of-the-relative-effectiveness-of-four-food-additives-in-degrading-aflatoxin-in-distillers-wet-grains-and-condensed-distillers-solubles
#5
H U Shi, Richard L Stroshine, Klein Ileleji
The food additives sodium bisulfite, sodium hypochlorite, citric acid, and ammonium persulfate were evaluated for their effectiveness in degrading aflatoxin in samples of distillers wet grains (DWG) and condensed distillers solubles (CDS) obtained from an industrial ethanol plant. Aqueous food additive solutions, 0.5% by weight, were added to DWG or CDS at the level of 0.5 ml/g of sample, and the materials were heated at 90°C for 1 h. Sodium bisulfite was not effective in degrading aflatoxin in either DWG or CDS...
January 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28221791/adiabatic-variational-theory-for-cold-atom-molecule-collisions-application-to-metastable-helium-atom-colliding-with-ortho-and-para-hydrogen-molecule
#6
Mariusz Pawlak, Yuval Shagam, Ayelet Klein, Edvardas Narevicius, Nimrod Moiseyev
We recently developed an adiabatic theory for cold molecular collision experiments. In our previous application of this theory, we assumed that during the experiment the collision of an atom with a diatom takes place when the diatom is in the ground rotational state and is located in a plane. In this paper, we present how the variational approach of the adiabatic theory for low-temperature collision experiments can be used for the study a 5D collision between the atom and the diatomic molecule with no limitations on its rotational quantum states and no plane restrictions...
February 21, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28221376/cell-biology-zipping-the-casparian-strip
#7
Silvia Melina Velasquez, Jürgen Kleine-Vehn
No abstract text is available yet for this article.
August 2, 2016: Nature Plants
https://www.readbyqxmd.com/read/28221196/fdg-brain-pet-ct-revealing-bilateral-thalamostriatal-activation-during-a-symptomatic-episode-in-a-patient-with-kleine-levin-syndrome
#8
Clément Drouet, Olivier Morel, Antoine Verger, Eric Guedj, Hatem Boulahdour
We report the case of a 14-year-old girl with clinically diagnosed Kleine-Levin syndrome. Electroencephalogram and brain MRI were unremarkable. An FDG PET/CT scan was acquired during a symptomatic episode, while she was asleep, and another PET scan was obtained when she was asymptomatic, awake, and quiet. Comparison of both examinations demonstrated a bilateral activation of thalami, caudate nuclei, and lenticular nuclei. These findings may be linked to the implication of thalamostriatal structures in the regulation of sleep and wakefulness...
February 17, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28220786/intrauterine-zika-virus-infection-of-pregnant-immunocompetent-mice-models-transplacental-transmission-and-adverse-perinatal-outcomes
#9
Meghan S Vermillion, Jun Lei, Yahya Shabi, Victoria K Baxter, Nathan P Crilly, Michael McLane, Diane E Griffin, Andrew Pekosz, Sabra L Klein, Irina Burd
Zika virus (ZIKV) crosses the placenta and causes congenital disease. Here we develop an animal model utilizing direct ZIKV inoculation into the uterine wall of pregnant, immunocompetent mice to evaluate transplacental transmission. Intrauterine inoculation at embryonic day (E) 10, but not E14, with African, Asian or American strains of ZIKV reduces fetal viability and increases infection of placental and fetal tissues. ZIKV inoculation at E10 causes placental inflammation, placental dysfunction and reduces neonatal brain cortical thickness, which is associated with increased activation of microglia...
February 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/28219491/predictors-and-outcomes-of-childhood-primary-enuresis
#10
Ellen M Kessel, Anna E S Allmann, Brandon L Goldstein, Megan Finsaas, Lea R Dougherty, Sara J Bufferd, Gabrielle A Carlson, Daniel N Klein
OBJECTIVE: Although enuresis is relatively common in early childhood, research exploring its antecedents and implications is surprisingly limited, perhaps because the condition typically remits in middle childhood. METHOD: We examined the prevalence, predictors, prognostic factors, and outcomes of primary enuresis in a large (N = 559) multi-method, multi-informant prospective study with a community-based sample of children followed from age 3 years to age 9 years...
March 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28218415/reduced-penetrance-of-leucine-rich-repeat-kinase-2-mutations-discovering-genetic-factors-of-endogenous-disease-protection
#11
Alexander Balck, Christine Klein
No abstract text is available yet for this article.
February 20, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28218274/trapping-of-ivermectin-by-a-pentameric-ligand-gated-ion-channel-upon-open-to-closed-isomerization
#12
Nurit Degani-Katzav, Moshe Klein, Moran Har-Even, Revital Gortler, Ruthi Tobi, Yoav Paas
Ivermectin (IVM) is a broad-spectrum anthelmintic drug used to treat human parasitic diseases like river blindness and lymphatic filariasis. By activating invertebrate pentameric glutamate-gated chloride channels (GluCl receptors; GluClRs), IVM induces sustained chloride influx and long-lasting membrane hyperpolarization that inhibit neural excitation in nematodes. Although IVM activates the C. elegans heteromeric GluClα/β receptor, it cannot activate a homomeric receptor composed of the C. elegans GluClβ subunits...
February 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28217330/crystal-structure-of-tris-4-7-13-16-21-24-hexa-oxa-1-10-di-aza-bicyclo-8-8-8-hexa-cosane-%C3%AE%C2%BA-8-n2-o6-rubidium-rubidium-nona-stannide
#13
Wilhelm Klein, Haiyan He, Thomas F Fässler
The crystal structure of the title compound, [Rb(C18H36N2O6)]3RbSn9, consists of deltahedral [Sn9](4-) cluster anions, Rb(+) cations and cryptand mol-ecules, which partially sequester the cations. Those cations, which are not coordinated by cryptand mol-ecules, are neighboured directly to the [Sn9](4-) clusters and inter-connect them to form ∞(1)[RbSn9](3-) chains. These chains extend parallel to [001] and are arranged in a pseudo-hexa-gonal rod packing, separated by the Rb-cryptand complex cations.
February 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28216256/kleine-levin-syndrome
#14
REVIEW
Olufunke Afolabi-Brown, Thornton B A Mason
Kleine-Levin syndrome (KLS) is a rare disorder characterized by discrete episodes of hypersomnia associated with cognitive and behavioural abnormalities, as well as normal alertness and function between episodes. The prevalence of KLS may be underestimated as it is often misdiagnosed and managed as another sleep disorder, neurological disorder or psychiatric condition. KLS is more typically seen in adolescence than at other ages, and is more common in males than in females. There are currently neither standard biomarkers nor specific imaging study findings, making the diagnosis of KLS a challenge...
December 23, 2016: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/28212369/prognostic-biomarkers-in-early-stage-prostate-cancer
#15
Eric Klein
No abstract text is available yet for this article.
January 2017: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/28211727/analytic-gravitational-waveforms-for-generic-precessing-binary-inspirals
#16
Katerina Chatziioannou, Antoine Klein, Neil Cornish, Nicolás Yunes
Binary systems of two compact objects circularize and spiral toward each other via the emission of gravitational waves. The coupling of the spins of each object with the orbital angular momentum causes the orbital plane to precess, which leads to modulation of the gravitational wave signal. Until now, generating frequency-domain waveforms for fully precessing systems for use in gravitational wave data analysis meant numerically integrating the equations of motion, then Fourier transforming the result, which is very computationally intensive for systems that complete hundreds or thousands of cycles in the sensitive band of a detector...
February 3, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28211093/gsskat-rapid-gene-set-analysis-and-multiple-testing-correction-for-rare-variant-association-studies-using-weighted-linear-kernels
#17
Nicholas B Larson, Shannon McDonnell, Lisa Cannon Albright, Craig Teerlink, Janet Stanford, Elaine A Ostrander, William B Isaacs, Jianfeng Xu, Kathleen A Cooney, Ethan Lange, Johanna Schleutker, John D Carpten, Isaac Powell, Joan E Bailey-Wilson, Olivier Cussenot, Geraldine Cancel-Tassin, Graham G Giles, Robert J MacInnis, Christiane Maier, Alice S Whittemore, Chih-Lin Hsieh, Fredrik Wiklund, William J Catolona, William Foulkes, Diptasri Mandal, Rosalind Eeles, Zsofia Kote-Jarai, Michael J Ackerman, Timothy M Olson, Christopher J Klein, Stephen N Thibodeau, Daniel J Schaid
Next-generation sequencing technologies have afforded unprecedented characterization of low-frequency and rare genetic variation. Due to low power for single-variant testing, aggregative methods are commonly used to combine observed rare variation within a single gene. Causal variation may also aggregate across multiple genes within relevant biomolecular pathways. Kernel-machine regression and adaptive testing methods for aggregative rare-variant association testing have been demonstrated to be powerful approaches for pathway-level analysis, although these methods tend to be computationally intensive at high-variant dimensionality and require access to complete data...
February 16, 2017: Genetic Epidemiology
https://www.readbyqxmd.com/read/28211036/unconscious-phantasy-as-a-structural-principle-and-organizer-of-mental-life-the-evolution-of-a-concept-from-freud-to-klein-and-some-of-her-successors
#18
Heinz Weiss
Starting with Freud's discovery of unconscious phantasy as a means of accessing his patients' internal world, the author discusses the evolution of the concept in the work of Melanie Klein and some of her successors. Whereas Freud sees phantasy as a wish fulfilling imagination, dominated by primary process functioning and kept apart from reality testing, Klein understands phantasies as a structural function and organizer of mental life. From their very beginnings they involve object relations and gradually evolve from primitive body-near experiences to images and symbolic representations...
February 17, 2017: International Journal of Psycho-analysis
https://www.readbyqxmd.com/read/28210359/intentional-recreational-abuse-of-quetiapine-compared-to-other-second-generation-antipsychotics
#19
Lauren Klein, Stacey Bangh, Jon B Cole
INTRODUCTION: Case reports and poison center data have demonstrated that the second-generation antipsychotic quetiapine is being obtained and used for recreational abuse. The purpose of this study was to describe the relative rates of single-substance abuse for different atypical antipsychotics and compare their demographic and clinical features. METHODS: We conducted a 10-year retrospective analysis of the National Poison Data System (NPDS) database (2003 - 2013)...
February 2017: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28209968/activating-akt1-mutations-alter-dna-double-strand-break-repair-and-radiosensitivity
#20
S Oeck, K Al-Refae, H Riffkin, G Wiel, R Handrick, D Klein, G Iliakis, V Jendrossek
The survival kinase Akt has clinical relevance to radioresistance. However, its contributions to the DNA damage response, DNA double strand break (DSB) repair and apoptosis remain poorly defined and often contradictory. We used a genetic approach to explore the consequences of genetic alterations of Akt1 for the cellular radiation response. While two activation-associated mutants with prominent nuclear access, the phospho-mimicking Akt1-TDSD and the clinically relevant PH-domain mutation Akt1-E17K, accelerated DSB repair and improved survival of irradiated Tramp-C1 murine prostate cancer cells and Akt1-knockout murine embryonic fibroblasts in vitro, the classical constitutively active membrane-targeted myrAkt1 mutant had the opposite effects...
February 17, 2017: Scientific Reports
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