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https://www.readbyqxmd.com/read/29150367/ileocolic-intussusception-predicting-the-probability-of-success-of-ultrasound-guided-saline-enema-from-clinical-and-sonographic-data
#1
REVIEW
A Soria, L Riaza, D Cuadras, X Tarrado, L Krauel
BACKGROUND/PURPOSE: To identify factors that dim the efficacy of ultrasound guided saline enema (USGSE) and to design a mathematical model for predicting the probability of success of USGSE. METHODS: Retrospective review of patients admitted with the diagnosis of ileocolic intussusception from 2009 to 2014. Demographics, clinical and sonographic data were reviewed. RESULTS: 116 first episodes of ileocolic intussusceptions. 109 USGSE attempts were analyzed...
November 14, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29150145/neuroimaging-biomarkers-as-predictors-of-treatment-outcome-in-major-depressive-disorder
#2
REVIEW
Trehani M Fonseka, Glenda M MacQueen, Sidney H Kennedy
BACKGROUND: Current practice for selecting pharmacological and non-pharmacological antidepressant treatments has yielded low response and remission rates in Major Depressive Disorder (MDD). Neuroimaging biomarkers of brain structure and function may be useful in guiding treatment selection by predicting response vs. non-response outcomes. METHODS: In this review, we summarize data from studies examining predictors of treatment response using structural and functional neuroimaging modalities, as they pertain to pharmacotherapy, psychotherapy, and stimulation treatment strategies...
October 31, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29149829/the-validation-path-of-hypoxia-pet-imaging-a-focus-on-brain-tumours
#3
Natale Quartuccio, Marie-Claude Asselin
Gliomas are brain tumours arising from the glia, the supportive tissue of the central nervous system (CNS) and constitute the commonest primary malignant brain tumours. Gliomas are graded from grade I to IV according to their appearance under microscope. One of the most significant adverse features of high-grade gliomas (grade III-IV) is hypoxia, a biological phenomenon that develops when the oxygen concentration becomes insufficient to guarantee the normal functions of a tissue. Since tissue hypoxia influences negatively patient outcome and targeting hypoxia has potential therapeutic implications, there is currently great interest in imaging techniques measuring hypoxia...
November 16, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29149644/assessing-the-risk-of-laparoscopic-morcellation-of-occult-uterine-sarcomas-during-hysterectomy-and-myomectomy-literature-review-and-the-isge-recommendations
#4
REVIEW
Ornella Sizzi, Lucia Manganaro, Alfonso Rossetti, Matteo Saldari, Giuseppe Florio, Alessandro Loddo, Robert Zurawin, Bruno van Herendael, Dusan Djokovic
OBJECTIVE: This project of the International Society for Gynecologic Endoscopy (ISGE) had the objective to review the literature and provide recommendations on the occult sarcoma risk assessment in patients who are candidates for minimally invasive gynecological surgery involving intra-abdominal electromechanical tissue morcellation. STUDY DESIGN: The ISGE Task Force for Estimation of the Risk in Endoscopic Morcellation initially defined key topics and clinical questions which may guide a comprehensive preoperative patient assessment...
November 7, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29148310/biventricular-repair-of-double-outlet-right-ventricle-preoperative-echocardiography-and-surgical-outcomes
#5
Hong Meng, Kun-Jing Pang, Shou-Jun Li, David Hsi, Jun Yan, Sheng-Shou Hu, Zhong-Dong Hua, Hao Wang
OBJECTIVE: To discuss the key anatomic features of double outlet right ventricle (DORV) assessed by preoperative echocardiography among patients treated with different types of biventricular repair. METHODS: Surgical and echocardiographic databases were queried to identify patients who had undergone biventricular repair for DORV and had adequate preoperative echocardiographic imaging. All patients underwent pre- and postoperative echocardiography and clinical evaluation following discharge...
May 2017: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/29147766/pictorial-essay-imaging-findings-following-y90-radiation-segmentectomy-for-hepatocellular-carcinoma
#6
REVIEW
Ronald A Mora, Rehan Ali, Ahmed Gabr, Nadine Abouchaleh, Ali Al Asadi, Joseph Ralph Kallini, Frank H Miller, Vahid Yaghmai, Samdeep Mouli, Bartley Thornburg, Kush Desai, Ahsun Riaz, Robert J Lewandowski, Riad Salem
Transarterial radioembolization is a novel therapy that has gained rapid clinical acceptance for the treatment of hepatocellular carcinoma (HCC). Segmental radioembolization [also termed radiation segmentectomy (RS)] is a technique that can deliver high doses (> 190 Gy) of radiation selectively to the hepatic segment(s) containing the tumor. The aim of this comprehensive review is to provide an illustrative summary of the most relevant imaging findings encountered after radiation segmentectomy. A 62-patient cohort of Child-Pugh A patients with solitary HCC < 5 cm in size was identified...
November 17, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29147448/lessons-from-managing-the-breast-malignant-adenomyoepithelioma-and-the-discussion-on-treatment-strategy
#7
Zhu Yuan, Xiang Qu, Zhong-Tao Zhang, Wen G Jiang
This study set out to investigate the clinical diagnosis and treatment strategies for malignant breast adenomyoepithelioma (AME), thus increasing the clinical knowledge on such disease. Two patients with malignant breast AME in Beijing Friendship Hospital were selected for study. Here we report the diagnosis and treatment processes in terms of the failure experience and lessons and relate our findings to those in the literature. Malignant breast AME is inclined to affect the areola area. It is recommended to conduct simple mastectomy combined with sentinel lymph node dissection due to the low sensitivity of the preoperative imaging diagnosis and difficulty in the pathological diagnosis...
August 2017: World Journal of Oncology
https://www.readbyqxmd.com/read/29146718/deep-brain-nuclei-t1-shortening-after-gadobenate-dimeglumine-in-children-influence-of-radiation-and-chemotherapy
#8
S Kinner, T B Schubert, R J Bruce, S L Rebsamen, C A Diamond, S B Reeder, H A Rowley
BACKGROUND AND PURPOSE: Intrinsic T1-hyperintense signal has recently been reported in the deep gray nuclei on brain MR imaging after multiple doses of gadolinium-based contrast agents. Most reports have included adult patients and excluded those undergoing radiation or chemotherapy. We investigated whether T1 shortening is also observed in children and tried to determine whether radiochemotherapy is a risk factor for this phenomenon. MATERIALS AND METHODS: In this single-center retrospective study, we reviewed clinical charts and images of all patients 18 years of age or younger with ≥4 gadobenate dimeglumine-enhanced MRIs for 6 years...
November 16, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29145836/clinical-utility-of-computed-tomography-hounsfield-characterization-for-percutaneous-nephrolithotomy-a-cross-sectional-study
#9
Andrea Gallioli, Elisa De Lorenzis, Luca Boeri, Maurizio Delor, Stefano Paolo Zanetti, Fabrizio Longo, Alberto Trinchieri, Emanuele Montanari
BACKGROUND: Computed Tomography (CT) is considered the gold-standard for the pre-operative evaluation of urolithiasis. However, no Hounsfield (HU) variable capable of differentiating stone types has been clearly identified. The aim of this study is to assess the predictive value of HU parameters on CT for determining stone composition and outcomes in percutaneous nephrolithotomy (PCNL). METHODS: Seventy seven consecutive cases of PCNL between 2011 and 2016 were divided into 4 groups: 40 (52%) calcium, 26 (34%) uric acid, 5 (6%) struvite and 6 (8%) cystine stones...
November 16, 2017: BMC Urology
https://www.readbyqxmd.com/read/29145690/-visual-analysis-of-retinal-oct-data
#10
Martin Röhlig, Anselm Jünemann, Dagmar-Christiane Fischer, Ruby Kala Prakasam, Oliver Stachs, Heidrun Schumann
Optical coherence tomography (OCT) enables noninvasive high-resolution 3D imaging of the human retina, and thus plays a fundamental role in ophthalmology. Via OCT examination, even subtle retinal changes can be captured, which occur in very early stages of different diseases (e.g., glaucoma, diabetes mellitus, or age-related macular degeneration). Yet, analyzing the resulting data is challenging. Conventionally, OCT data are strongly aggregated via automated methods. While this reduces the amount of information to be analyzed, it also makes it difficult, if not impossible, to identify small and localized retinal changes...
November 16, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29145584/critical-lessons-from-high-value-oncology-practices
#11
Douglas W Blayney, Melora K Simon, Beatrice Podtschaske, Scott Ramsey, Margaret Shyu, Craig Lindquist, Arnold Milstein
Importance: Cancer care is expensive. Cancer care provided by practice organizations varies in total spending incurred by patients and payers during treatment episodes and in quality of care, and this unnecessary variation contributes to the high cost. Objective: To use the variation in total spending and quality of care to assess oncology practice attributes distinguishing "high value" that may be tested and adopted by others to produce similar results. Design, Setting, and Participants: "Positive deviance" was used in this exploratory mixed-methods (quantitative and qualitative) analysis of interview results...
November 16, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/29144166/imaging-assessment-of-acute-ischaemic-stroke-a-review-of-radiological-methods
#12
Aubrey Smith, Chris Rowland Hill
Acute ischaemic stroke is the second largest cause of death worldwide and a cause of major physical and psychological morbidity. Current evidence based treatment includes intravenous thrombolysis (IVT) and mechanical thrombectomy (MT), both requiring careful patient selection and to be administered as quickly as possible within a limited time window from symptom onset. Imaging plays a crucial role identifying patients who may benefit from MT or IVT whilst excluding those that maybe harmed. For IVT, imaging must as a minimum exclude haemorrhage, stroke mimics and provide an estimate of non-viable brain...
November 16, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29143901/combined-vertebral-augmentation-and-radiofrequency-ablation-in-the-management-of-spinal-metastases-an-update
#13
REVIEW
Ning Mao Kam, Julian Maingard, Hong Kuan Kok, Dinesh Ranatunga, Duncan Brooks, William C Torreggiani, Peter L Munk, Michael J Lee, Ronil V Chandra, Hamed Asadi
Spinal metastases are the most commonly encountered tumour of the spine, occurring in up to 40% of patients with cancer. Each year, approximately 5% of cancer patients will develop spinal metastases. This number is expected to increase as the life expectancy of cancer patients increases. Patients with spinal metastases experience severe and frequently debilitating pain, which often decreases their remaining quality of life. With a median survival of less than 1 year, the goals of treatment in spinal metastases are reducing pain, improving or maintaining level of function and providing mechanical stability...
November 16, 2017: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/29143481/decisional-regret-and-choice-of-breast-reconstruction-following-mastectomy-for-breast-cancer-a-systematic-review
#14
REVIEW
Kathy Flitcroft, Meagan Brennan, Andrew Spillane
OBJECTIVE: Women facing mastectomy for breast cancer should have the option of considering whether they would like breast reconstruction (BR), and if so, what type and when. Previous research has demonstrated some women will come to regret their decision about BR. We aim to summarise the evidence about the prevalence of decisional regret (DR) associated with BR choices and identify factors influencing vulnerability to DR. METHODS: A systematic review of the literature reporting BR-related DR published between January 1994 and February 2017 identified 254 initial search results...
November 16, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/29142971/total-kidney-volume-is-a-prognostic-biomarker-of-renal-function-decline-and-progression-to-end-stage-renal-disease-in%C3%A2-patients-with-autosomal-dominant-polycystic-kidney-disease
#15
Ronald D Perrone, Mohamad-Samer Mouksassi, Klaus Romero, Frank S Czerwiec, Arlene B Chapman, Berenice Y Gitomer, Vicente E Torres, Dana C Miskulin, Steve Broadbent, Jean F Marier
Introduction: Autosomal dominant polycystic kidney disease is the most common hereditary kidney disease. TKV is a promising imaging biomarker for tracking and predicting the natural history of autosomal dominant polycystic kidney disease. The prognostic value of TKV was evaluated, in combination with age and eGFR, for the outcomes of 30% decline in eGFR and progression to ESRD. Observational data including 2355 patients with TKV measurements were available. Methods: Multivariable Cox models were developed to assess the prognostic value of age, TKV, height-adjusted TKV, eGFR, sex, race, and genotype for the probability of a 30% decline in eGFR or ESRD...
May 2017: KI Reports
https://www.readbyqxmd.com/read/29142539/values-of-magnetic-resonance-imaging-and-cerebrospinal-fluid-analysis-in-the-diagnosis-of-central-nervous-system-associated-infectious-diseases
#16
Dongfeng Zhang
Objective: To discuss the roles of magnetic resonance imaging (MRI) and cerebrospinal fluid analysis in the identification of central nervous system associated infection and provide a reference for the diagnosis and treatment of central nervous system associated infectious diseases. Methods: Seventy-six patients who developed central nervous system infection and were admitted into the Henan People's Hospital between June 2014 and October 2015 were randomly selected as an observation group...
September 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29142240/robust-segmentation-of-the-full-cerebral-vasculature-in-4d-ct-of-suspected-stroke-patients
#17
Midas Meijs, Ajay Patel, Sil C van de Leemput, Mathias Prokop, Ewoud J van Dijk, Frank-Erik de Leeuw, Frederick J A Meijer, Bram van Ginneken, Rashindra Manniesing
A robust method is presented for the segmentation of the full cerebral vasculature in 4-dimensional (4D) computed tomography (CT). The method consists of candidate vessel selection, feature extraction, random forest classification and postprocessing. Image features include among others the weighted temporal variance image and parameters, including entropy, of an intensity histogram in a local region at different scales. These histogram parameters revealed to be a strong feature in the detection of vessels regardless of shape and size...
November 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29142019/molecular-imaging-of-glut1-and-glut5-in-breast-cancer-a-multitracer-pet-imaging-study-in-mice
#18
Melinda Wuest, Ingrit Hamann, Vincent Bouvet, Darryl Glubrecht, Alison Marshall, Brendan Trayner, Olivier Soueidan, Daniel Krys, Michael Wagner, Chris Cheeseman, Frederick West, Frank Wuest
Use of [18F]FDG-PET in clinical breast cancer (BC) imaging is limited mainly due to insufficient expression levels of GLUT1 in up to 50% of all patients. Fructose-specific facilitative hexose transporter GLUT5 represents an alternative biomarker for PET imaging of hexose metabolism in BC. The goal of the present study was to compare uptake characteristics of selected hexose-based PET radiotracers in murine BC model EMT6. Uptake of 1-deoxy-1-[18F]fluoro-D-fructose (1-[18F]FDF), 6-deoxy-6-[18F]fluoro-D-fructose (6-[18F]FDF), 1-deoxy-1-[18F]fluoro-2,5-anhydro-mannitol (1-[18F]FDAM), 2-deoxy-2-[18F]fluoro-D-glucose (2-[18F]FDG) and 6-deoxy-6-[18F]fluoro-D-glucose (6-[18F]FDG) was studied in EMT6 cells, tumors and muscle and correlated to GLUT1 and GLUT5 expression levels...
November 15, 2017: Molecular Pharmacology
https://www.readbyqxmd.com/read/29141564/a-review-on-the-management-of-small-renal-masses-active-surveillance-versus-surgery
#19
Giancarlo Marra, Marco Oderda, Marco Allasia, Stefania Munegato, Steven Joniau, Paolo Gontero
Despite the rise of small renal tumour (SRMs) diagnosis and related surgeries, death rate of kidney cancer is increasing, suggesting a non-optimal management of SRMs. Active Surveillance (AS) for kidney cancer was introduced to face this paradox. However, incertitude remains on whether and when AS can replace surgery in selected patients. We performed a literature search, reviewed and discussed the evidence in favour of AS or surgery for SRMs. Histopathology and natural history of SRMs, including the percentage of benign tumours amongst SRMs, tumour growth rate, life expectancy of SRMs patients being generally older, and current results of AS series seem to support its use in selected groups...
November 13, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29141559/new-histopathological-genetic-features-to-improve-active-surveillance-selection-for-low-risk-prostate-cancer
#20
Lih-Ming Wong, Kevin Chu, Niall Corcoran, Sam Norden
BACKGROUND: A recent surge in biomarkers to aid management of men with prostate cancer has occurred. Their applications are varied and not all tests are applicable to the active surveillance setting. OBJECTIVE: To review primary evidence on genetic and immunohistochemical biomarkers, and their role on patient selection and risk stratification for men on active surveillance for prostate cancer. EVIDENCE ACQUISITION: A PubMed electronic search using the terms (biomarker or genetic or histopathological) AND ("prostate cancer" AND "active surveillance") was performed from inception to April 2015...
November 13, 2017: Anti-cancer Agents in Medicinal Chemistry
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