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Imaging patient selection

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https://www.readbyqxmd.com/read/28922885/patient-selection-and-clinical-efficacy-of-urgent-superficial-temporal-artery-middle-cerebral-artery-bypass-in-acute-ischemic-stroke-using-advanced-magnetic-resonance-imaging-techniques
#1
Hyun-Seok Park, Sang-Hyeon Kim, Hyun-Wook Nah, Jae-Hyung Choi, Dae-Hyun Kim, Myong-Jin Kang, Jae-Kwan Cha, Jae-Taeck Huh
BACKGROUND: Selected patients with acute ischemic stroke might benefit from superficial temporal artery-middle cerebral artery (STA-MCA) bypass, but the indications for urgent STA-MCA bypass are unknown. OBJECTIVE: To report our experiences of urgent STA-MCA bypass in patients requiring urgent reperfusion who were ineligible for other reperfusion therapies, using advanced magnetic resonance imaging (MRI) techniques. METHODS: The inclusion criteria for urgent STA-MCA bypass were as follows: acute infarct volume <70 mL with a ratio of perfusion/diffusion lesion volume ≥1...
October 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28922791/targeting-hypoxia-to-improve-non-small-cell-lung-cancer-outcome
#2
Ahmed Salem, Marie-Claude Asselin, Bart Reymen, Alan Jackson, Philippe Lambin, Catharine M L West, James P B O'Connor, Corinne Faivre-Finn
Oxygen deprivation (hypoxia) in non-small cell lung cancer (NSCLC) is an important factor in treatment resistance and poor survival. Hypoxia is an attractive therapeutic target, particularly in the context of radiotherapy, which is delivered to more than half of NSCLC patients. However, NSCLC hypoxia-targeted therapy trials have not yet translated into patient benefit. Recently, early termination of promising evofosfamide and tarloxotinib bromide studies due to futility highlighted the need for a paradigm shift in our approach to avoid disappointments in future trials...
January 1, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28922524/dynamic-contrast-enhanced-mri-in-orbital-lymphoproliferative-disorders-effects-of-region-of-interest-selection-methods-on-time-efficiency-measurement-reproducibility-and-diagnostic-ability
#3
Wen Qian, Xiao-Quan Xu, Hao Hu, Guo-Yi Su, Jiang-Fen Wu, Hai-Bin Shi, Fei-Yun Wu
BACKGROUND: Previous studies indicated that dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) could serve as a useful biomarker for differentiating malignant from benign orbital lymphoproliferative disorders (OLPDs). PURPOSE: To investigate the influence of different region of interest (ROI) selection methods on the measurements of DCE-MRI parameters, and their diagnostic ability in discriminating malignant from benign OLPDs. STUDY TYPE: Retrospective study...
September 18, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28922286/nocardia-infections-in-solid-organ-and-hematopoietic-stem-cell-transplant-recipients
#4
Julien Coussement, David Lebeaux, Claire Rouzaud, Olivier Lortholary
PURPOSE OF REVIEW: Nocardia spp. is a gram-positive bacteria that may cause infections in humans. Nocardiosis has been described since the early years of transplantation. This review aims to provide an overview of present knowledge regarding posttransplant nocardiosis, with a focus on recent findings. RECENT FINDINGS: Nocardiosis is not rare among transplant recipients, especially after thoracic transplantation and/or in case of intense immunosuppressive regimen or use of tacrolimus...
September 15, 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/28921613/voxel-based-multi-model-fitting-method-for-modelling-time-activity-curves-in-spect-images
#5
David Sarrut, Adrien Halty, Jean-Noel Badel, Ludovic Ferrer, Manuel Bardiès
PURPOSE: Estimating the biodistribution and the pharmacokinetics from timesequence SPECT images on a per-voxel basis is useful for studying activity nonuniformity or computing absorbed dose distributions by convolution of voxel kernels or Monte-Carlo radiation transport. Current approaches are either region-based, thus assuming uniform activity within the region, or voxel-based but using the same fitting model for all voxels. METHODS: We propose a voxel-based multi-model fitting method (VoMM) that estimates a fitting function for each voxel by automatically selecting the most appropriate model among a predetermined set with Akaike criteria...
September 17, 2017: Medical Physics
https://www.readbyqxmd.com/read/28921538/a-fast-inverse-treatment-planning-strategy-facilitating-optimized-catheter-selection-in-image-guided-high-dose-rate-interstitial-gynecologic-brachytherapy
#6
Christian V Guthier, Antonio L Damato, Juergen W Hesser, Akila N Viswanathan, Robert A Cormack
PURPOSE: Interstitial high-dose-rate (HDR) brachytherapy is an important therapeutic strategy for the treatment of locally advanced gynecologic (GYN) cancers. The outcome of this therapy is determined by the quality of dose distribution achieved. This paper focuses on a novel yet simple heuristic for catheter selection for GYN HDR brachytherapy and their comparison against state of the art optimization strategies. The proposed technique is intended to act as a decision-supporting tool to select a favorable needle configuration...
September 18, 2017: Medical Physics
https://www.readbyqxmd.com/read/28920557/automated-microspect-microct-image-analysis-of-the-mouse-thyroid-gland
#7
Peng Cheng, Brynn Hollingsworth, Daniel Scarberry, Daniel Hueng-Yuan Shen, Kimerly Powell, Sean C Smart, John Beech, Xiaochao Sheng, Lawrence S Kirschner, Chia-Hsiang Menq, Sissy M Jhiang
<b>Background:</b> The ability of thyroid follicular cells to take up iodine enables the use of radioactive iodine (RAI) for imaging and targeted killing of RAI-avid thyroid cancer following thyroidectomy. To facilitate identifying novel strategies to improve <sup>131</sup>I therapeutic efficacy for patients with RAI refractory disease, it is desired to optimize image acquisition and analysis for preclinical mouse models of thyroid cancer. <b>Methods:</b> A customized mouse cradle was designed and used for microSPECT/CT image acquisition at 1 hour (t1) and 24 hours (t24) post-injection of <sup>123</sup>I, which mainly reflect RAI influx/efflux equilibrium and RAI retention in the thyroid, respectively...
September 16, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28920082/is-a-persistent-central-canal-a-risk-factor-for-neurological-injury-in-patients-undergoing-surgical-correction-of-scoliosis
#8
Steven Kyriacou, Yuen Man, Karen Plumb, Matthew Shaw, Kia Rezajooi
BACKGROUND: Scoliosis patients with associated syringomyelia are at an increased risk of neurological injury during surgical deformity correction. The syrinx is therefore often addressed surgically prior to scoliosis correction to minimize this risk. It remains unclear if the presence of a persistent central canal (PCC) within the spinal cord also poses a similar risk. The aim of this study is to determine whether there is any evidence to suggest that patients with a PCC are also at a higher risk of neurological injury during surgical scoliosis correction...
2017: Scoliosis and Spinal Disorders
https://www.readbyqxmd.com/read/28919822/uterine-sarcoma-current-perspectives
#9
REVIEW
Charlotte Benson, Aisha B Miah
Uterine sarcomas comprise a group of rare tumors with differing tumor biology, natural history and response to treatment. Diagnosis is often made following surgery for presumed benign disease. Currently, preoperative imaging does not reliably distinguish between benign leiomyomas and other malignant pathology. Uterine leiomyosarcoma is the most common sarcoma, but other subtypes include endometrial stromal sarcoma (low grade and high grade), undifferentiated uterine sarcoma and adenosarcoma. Clinical trials have shown no definite survival benefit of adjuvant radiotherapy or chemotherapy and have been hampered by the rarity and heterogeneity of these disease types...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/28919703/quality-and-learning-curve-of-handheld-versus-stand-alone-non-mydriatic-cameras
#10
Mariya Gosheva, Christian Klameth, Lars Norrenberg, Lucien Clin, Johannes Dietter, Wadood Haq, Iliya V Ivanov, Focke Ziemssen, Martin A Leitritz
PURPOSE: Nowadays, complex digital imaging systems allow detailed retinal imaging without dilating patients' pupils. These so-called non-mydriatic cameras have advantages in common circumstances (eg, for screening or emergency purposes) but present limitations in terms of image quality and field of view. We compare the usefulness of two non-mydriatic camera systems (ie, a handheld versus a stand-alone device) for fundus imaging. The primary outcome was image quality. The secondary outcomes were learning effects and quality grade-influencing factors...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28919565/treatment-of-large-or-giant-cavernous-aneurysm-associated-with-a-persistent-trigeminal-artery-a-case-report-and-review-of-literature
#11
Tatsuya Ishikawa, Koji Yamaguchi, Hidenori Anami, Masatake Sumi, Tomomi Ishikawa, Takakazu Kawamata
BACKGROUND: Primitive trigeminal artery (PTA) is the most common anomaly of primitive carotid-basilar anastomosis and is associated with cerebrovascular anomalies, such as aneurysm. Large or giant cavernous aneurysm associated with PTA is rare, and the treatment strategies differ in comparison to large or giant aneurysm without PTA. In this article, we report an unusual case of a giant cavernous aneurysm associated with PTA and review treatment strategies for large or giant cavernous aneurysm associated with PTA...
September 14, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28919265/pretherapeutic-staging-of-locally-advanced-cervical-cancer-inframesenteric-paraaortic-lymphadenectomy-accuracy-to-detect-paraaortic-metastases-in-comparison-with-infrarenal-paraaortic-lymphadenectomy
#12
Henri Azaïs, Louise Ghesquière, Clothilde Petitnicolas, Yves Borghesi, Emmanuelle Tresch-Bruneel, Abel Cordoba, Fabrice Narducci, Lucie Bresson, Eric Leblanc
BACKGROUND: Extended-field chemoradiation therapy is usually performed in patients with locally advanced cervical cancer (LACC) and paraaortic (PA) node metastases. Considering the very low rate of skip metastases above inferior mesenteric artery, ilio-inframesenteric paraaortic lymph node dissection (IM-PALND) seems to be an adequate pattern of PALND. Our objective was to assess the accuracy of this management to determine PA nodal status in comparison with infrarenal paraaortic lymphadenectomy (IR-PALND) in case of squamous or glandular cervical cancer...
September 14, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28919003/inter-observer-agreement-in-gtv-delineation-of-bone-metastases-on-ct-and-impact-of-mr-imaging-a-multicenter-study
#13
A S Gerlich, J M van der Velden, A N T J Kotte, C L Tseng, G Fanetti, W S C Eppinga, N Kasperts, M P W Intven, F A Pameijer, M E P Philippens, H M Verkooijen, E Seravalli
BACKGROUND AND PURPOSE: The use of Stereotactic Body Radiotherapy (SBRT) for bone metastases is increasing rapidly. Therefore, knowledge of the inter-observer differences in tumor volume delineation is essential to guarantee precise dose delivery. The aim of this study is to compare inter-observer agreement in bone metastases delineated on different imaging modalities. MATERIAL AND METHODS: Twenty consecutive patients with bone metastases treated with SBRT were selected...
September 14, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28918956/healthcare-utilization-and-expenditures-for-united-states-medicare-beneficiaries-with-systemic-vasculitis
#14
Carolyn T Thorpe, Joshua M Thorpe, Tao Jiang, Dylan Atkinson, Yihuang Kang, Loren J Schleiden, Delesha M Carpenter, Julie Anne G McGregor, Susan L Hogan
OBJECTIVE: The Medicare federal insurance program is the most common United States insurer of patients with systemic vasculitis (SV). We compared healthcare utilization and expenditures for Medicare beneficiaries with versus without SV. METHODS: This national, retrospective study used 2010 claims and enrollment data for a 100% cohort of Medicare Part A and B beneficiaries with ≥1 claim including a diagnosis for a form of SV (n = 176,498), and a randomly selected group of non-SV beneficiaries (n = 46,561)...
August 10, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28918686/sensitivity-of-post-treatment-positron-emission-tomography-computed-tomography-to-detect-inter-fractional-range-variations-in-scanned-ion-beam-therapy
#15
Josefine Handrack, Thomas Tessonnier, Wenjing Chen, Jakob Liebl, Jürgen Debus, Julia Bauer, Katia Parodi
BACKGROUND: Ion therapy, especially with modern scanning beam delivery, offers very sharp dose gradients for highly conformal cancer treatment. However, it is very sensitive to uncertainties of tissue stopping properties as well as to anatomical changes and setup errors, making range verification highly desirable. To this end, positron emission tomography (PET) can be used to measure decay products of β(+)-emitters created in interactions inside the patient. This work investigates the sensitivity of post treatment PET/CT (computed tomography) to detect inter-fractional range variations...
September 18, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28917684/role-of-low-endothelial-shear-stress-and-plaque-characteristics-in-the-prediction-of-nonculprit-major-adverse-cardiac-events-the-prospect-study
#16
Peter H Stone, Akiko Maehara, Ahmet Umit Coskun, Charles C Maynard, Marina Zaromitydou, Gerasimos Siasos, Ioannis Andreou, Dimitris Fotiadis, Kostas Stefanou, Michail Papafaklis, Lampros Michalis, Alexandra J Lansky, Gary S Mintz, Patrick W Serruys, Charles L Feldman, Gregg W Stone
OBJECTIVES: This study sought to determine whether low endothelial shear stress (ESS) adds independent prognostication for future major adverse cardiac events (MACE) in coronary lesions in patients with high-risk acute coronary syndrome (ACS) from the United States and Europe. BACKGROUND: Low ESS is a proinflammatory, proatherogenic stimulus associated with coronary plaque development, progression, and destabilization in human-like animal models and in humans. Previous natural history studies including baseline ESS characterization investigated low-risk patients...
September 9, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28917403/cataract-surgery-in-patients-with-late-onset-retinal-degeneration
#17
Vasileios T Papastavrou, Shyamanga Borooah, Jill M O'Brien, Neeta Ray-Chaudhuri, Baljean Dhillon, Rute V Vieira, Andrew C Browning
PURPOSE: To review the outcomes in a series of patients with long anterior lens zonular fibers associated with late-onset retinal degeneration who had phacoemulsification cataract surgery. SETTING: Newcastle Eye Centre, Newcastle upon Tyne, United Kingdom. DESIGN: Retrospective case series. METHODS: Inclusion criteria were patients with genetically confirmed late-onset retinal degeneration requiring cataract surgery...
August 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28917282/interventional-mri-guided-deep-brain-stimulation-lead-implantation
#18
REVIEW
Philip S Lee, Robert Mark Richardson
Current knowledge of the functional anatomy of the subthalamic nucleus and globus pallidus, discovered through microelectrode recording and postoperative imaging, justifies purely anatomic targeting for deep brain stimulation (DBS). Interventional MRI (iMRI)-DBS is more anatomically accurate than traditional awake procedures and has similar clinical outcomes without increased risk or increased operative times. iMRI lead implantation allows patients to receive DBS therapy who cannot tolerate or do not agree to undergo an awake procedure...
October 2017: Neurosurgery Clinics of North America
https://www.readbyqxmd.com/read/28917277/intraoperative-mri-and-maximizing-extent-of-resection
#19
REVIEW
Ganesh Rao
Intraoperative MRI (iMRI) is a neurosurgical adjunct used to maximize the removal of glioma, the most common primary brain tumor. Increased extent of resection of gliomas has been shown to correlate with longer survival times. iMRI units are variable in design and magnet strength, which can affect patient selection and image quality. Multiple studies have shown that surgical resection of gliomas using iMRI results in increased extent of resection and survival time. Level II evidence supports the use of iMRI in the surgical treatment of glioma...
October 2017: Neurosurgery Clinics of North America
https://www.readbyqxmd.com/read/28917256/postoperative-stereotactic-body-radiotherapy-for-spinal-metastases
#20
Majed Alghamdi, Chia-Lin Tseng, Sten Myrehaug, Pejman Maralani, Chris Heyn, Hany Soliman, Young Lee, Mark Ruschin, Leodante Da Costa, Victor Yang, Mikki Campbell, Arjun Sahgal
Spine is a common site of metastases in cancer patients. Spine surgery is indicated for select patients, typically those with mechanical instability and/or malignant epidural spinal cord (or cauda equina) compression. Although post-operative conventional palliative external beam radiation therapy has been the standard of care, technical improvements in radiation planning and image-guided radiotherapy have allowed for the application of stereotactic body radiotherapy (SBRT) to the spine. Spine SBRT is intended to ablate residual tumor and optimize local control by delivering several fold greater biologically effective doses...
September 2017: Chinese Clinical Oncology
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