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https://www.readbyqxmd.com/read/29352062/critical-role-of-angiographic-acquisition-modality-and-reconstruction-on-morphometric-and-haemodynamic-analysis-of-intracranial-aneurysms
#1
Alexandra Lauric, James E Hippelheuser, Adel M Malek
BACKGROUND: Subtracted 3-D rotational angiography (3DRA) and cone-beam computed tomography angiography (CBCT-A) are often used in assessing cerebral aneurysm shape and haemodynamic profile. We sought to evaluate the effect of imaging modality, reconstruction parameters, and kernel selection on patient-derived aneurysm morphology and computational fluid dynamic (CFD) analysis to assess its potential contribution to inter-study variability. METHODS: Four patients (five aneurysms) underwent concurrent 3DRA followed by high-resolution CBCT-A...
January 19, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29351690/the-transcondylar-approach-to-access-symptomatic-arachnoid-cysts-of-the-hypoglossal-canal
#2
Jan-Karl Burkhardt, Christina Bal, Marian Christoph Neidert, Oliver Bozinov
BACKGROUND AND IMPORTANCE: A direct transcondylar approach to treat symptomatic arachnoid cysts of the hypoglossal canal has not yet been described in the literature. CLINICAL PRESENTATION: Here, we present a skull base approach in 2 female patients (68 and 38 yr) with progressive dysphagia, dysarthria, half-sided weakness, and atrophy of the tongue due to an arachnoid cyst of the hypoglossal canal. After patient informed consent, both patients were successfully operated on without complications using a transcondylar approach, and their symptoms improved 3 mo after surgery; in both patients, resection of the cyst was confirmed using magnetic resonance imaging...
February 1, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29351635/reversibility-of-severe-mitral-valve-regurgitation-after-left-ventricular-assist-device-implantation-single-centre-observations-from-a-real-life-population-of-patients
#3
Monica Dobrovie, Ricardo A Spampinato, Elena Efimova, Jaqueline G da Rocha E Silva, Julia Fischer, Michael Kuehl, Jens-Uwe Voigt, Ann Belmans, Agnieszka Ciarka, Fernanda Bonamigo Thome, Valerie Schloma, Yaroslava Dmitrieva, Sven Lehmann, Jochen Hahn, Elfriede Strotdrees, Friedrich-Wilhelm Mohr, Jens Garbade, Anna L Meyer
OBJECTIVES: This study evaluates the impact of untreated preoperative severe mitral valve regurgitation (MR) on outcomes after left ventricular assist device (LVAD) implantation. METHODS: Of the 234 patients who received LVAD therapy in our centre during a 6-year period, we selected those who had echocardiographic images of good quality and excluded those who underwent mitral valve replacement prior to or mitral valve repair during LVAD placement. The 128 patients selected were divided into 2 groups: Group A with severe MR (n = 65) and Group B with none to moderate MR (n = 63, 28 with moderate MR)...
January 16, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29351615/18f-fluorodeoxyglucose-positron-emission-computed-tomography-and-computed-tomography-angiography-in-prosthetic-heart-valve-endocarditis-from-guidelines-to-clinical-practice
#4
Laurens E Swart, Asbjørn M Scholtens, Wilco Tanis, Koen Nieman, Ad J J C Bogers, Fred J Verzijlbergen, Gabriel P Krestin, Jolien W Roos-Hesselink, Ricardo P J Budde
The timely diagnosis of prosthetic heart valve endocarditis remains challenging yet of utmost importance. 18F-fluorodeoxyglucose (18 F-FDG) positron emission/computed tomography (PET/CT) and cardiac computed tomography angiography (CTA) were recently introduced as additional diagnostic tools in the most recent ESC guidelines on infective endocarditis. However, how to interpret PET/CT findings with regard to what is to be considered abnormal, what the potential confounders may be, as well as which patients benefit most from these additional imaging techniques and how to best perform them in these often-complex patients, remains unclear...
January 16, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29350878/perfusion-ct-in-posterior-circulation-stroke-predictors-and-prognostic-implications-of-focal-hypoperfusion
#5
Lars-Peder Pallesen, Dimitris Lambrou, Ashraf Eskandari, Jessica Barlinn, Kristian Barlinn, Heinz Reichmann, Vincent Dunet, Philippe Maeder, Volker Puetz, Patrik Michel
BACKGROUND: We aimed to determine predictors of focal hypoperfusion on CT Perfusion (CTP) in patients with acute posterior circulation stroke and its association with long-term outcome. METHODS: We selected patients with posterior circulation stroke from the Acute STroke Registry and Analysis of Lausanne (ASTRAL) who underwent CTP within 24 hours of stroke onset as part of the stroke imaging protocol. Hypoperfusion was defined as an area of visually well demarcated mean-transit-time (MTT) prolongation corresponding to an arterial territory on standard reconstruction CTP imaging maps...
January 19, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29350644/talar-fractures-radiological-and-ct-evaluation-and-classification-systems
#6
Giuseppe Caracchini, Michele Pietragalla, Alioscia De Renzis, Michele Galluzzo, Mattia Carbone, Marcello Zappia, Anna Russo, Federico Greco, Vittorio Miele
INTRODUCTION: The talus is the second largest bone of the foot. It is fundamental to ensure normal ankle-foot movements as it connects the leg and the foot. Talar fractures are usually due to high energy traumas (road accidents, high level falls). They are not common as they account for 3-5% of ankle and foot fractures and 0.85% of all body fractures. However, talar fractures not correctly diagnosed and treated can lead to avascular necrosis of the astragalus, pseudoarthrosis, early osteoarthrisis and ankle instability, declining the quality of life of patients...
January 19, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29350643/calcaneal-fractures-radiological-and-ct-evaluation-and-classification-systems
#7
Michele Galluzzo, Federico Greco, Michele Pietragalla, Alioscia De Renzis, Mattia Carbone, Marcello Zappia, Nicola Maggialetti, Alfredo D'andrea, Giuseppe Caracchini, Vittorio Miele
BACKGROUND AND AIM OF THE WORK: The calcaneus, the more lower bone of the body, has the task of supporting the axial load from the weight of the body. Calcaneal fractures represent about 1-2% of all fractures and 60% of the tarsal bones fractures. The articular involvement has been associated with a poor functional outcome. The aim of this work is to describe the radiologic evaluation, the classification systems, the morphological preoperative diagnostic imaging features of calcaneal fractures, highlighting the correlation with the choice of treatment and predictive capacity for the fracture surgical outcome...
January 19, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29350191/a-prospective-gating-method-to-acquire-a-diverse-set-of-free-breathing-ct-images-for-model-based-4dct
#8
Dylan O'Connell, Dan Ruan, David H Thomas, Tai H Dou, John H Lewis, Anand P Santhanam, Percy P Lee, Daniel A Low
Breathing motion modeling requires observation of tissues at sufficiently distinct respiratory states for proper 4D characterization. This work proposes a method to improve sampling of the breathing cycle with limited imaging dose. We designed and tested a prospective free-breathing acquisition protocol with a simulation using datasets from 5 patients imaged with a model-based 4DCT technique. Each dataset contained 25 free-breathing fast helical CT scans with simultaneous breathing surrogate measurements...
January 19, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29350098/commentary-to-18f-gp1-a-novel-pet-tracer-designed-for-high-sensitivity-low-background-detection-of-thrombi-imaging-activated-platelets-in-clots-are-we-getting-there
#9
Andrew W Stephens, Norman Koglin, Ludger M Dinkelborg
Thrombus formation can lead to heart attacks, stroke and pulmonary embolism, which are major causes of mortality. Current standard diagnostic imaging methods detect anatomic abnormalities such as vascular flow impairment but have limitations. By using a targeted molecular imaging approach critical components of a pathology can be selectively visualized and exploited for an improved diagnosis and patient management. The GPIIb/IIIa receptor is abundantly and specifically exposed on activated platelets and is the key receptor in thrombus formation...
January 2018: Molecular Imaging
https://www.readbyqxmd.com/read/29350015/-application-of-finite-element-method-in-spinal-biomechanics
#10
REVIEW
Qiang Liu, Jun Zhang, Shu-Chun Sun, Fei Wang
The finite element model is one of the most important methods in study of modern spinal biomechanics, according to the needs to simulate the various states of the spine, calculate the stress force and strain distribution of the different groups in the state, and explore its principle of mechanics, mechanism of injury, and treatment effectiveness. In addition, in the study of the pathological state of the spine, the finite element is mainly used in the understanding the mechanism of lesion location, evaluating the effects of different therapeutic tool, assisting and completing the selection and improvement of therapeutic tool, in order to provide a theoretical basis for the rehabilitation of spinal lesions...
February 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29350011/-treatment-of-ossification-of-ligamentum-flavum-complicated-with-lumbar-spinal-stenosis
#11
Xu Lan, Jie Gao, Jian-Zhong Xu, Xue-Mei Liu
OBJECTIVE: To investigate the imaging characteristic and operation outcome of ossification of ligamentum flavum with lumbar spinal stenosis. METHODS: January 2013 to January 2016, 9 patients with ossification of ligamentum flavum with lumbar spinal stenosis were treated, included 5 males and 4 females, aged from 51 to 63 years old with an average of 57 years old. All patients complained intermittent claudication and radiating pain at lower limb. The pathologic change regions examined by CT or MRI were as follows:2 cases in L₄,₅ and L₅S₁, 5 in L̀,̀, and 2 in L₅S₁...
February 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29349617/use-of-venovenous-ecmo-for-neonatal-and-pediatric-ecmo-a-decade-of-experience-at-a-tertiary-children-s-hospital
#12
Jennifer L Carpenter, Yangyang R Yu, Darrell L Cass, Oluyinka O Olutoye, James A Thomas, Cole Burgman, Caraciolo J Fernandes, Timothy C Lee
BACKGROUND: Advances in extracorporeal membrane oxygenation (ECMO) have led to increased use of venovenous (VV) ECMO in the pediatric population. We present the evolution and experience of pediatric VV ECMO at a tertiary care institution. METHODS: A retrospective cohort study from 01/2005 to 07/2016 was performed, comparing by cannulation mode. Survival to discharge, complications, and decannulation analyses were performed. RESULTS: In total, 160 patients (105 NICU, 55 PICU) required 13 ± 11 days of ECMO...
January 18, 2018: Pediatric Surgery International
https://www.readbyqxmd.com/read/29349601/prospective-feasibility-analysis-of-a%C3%A2-novel-off-line-approach-for-mr-guided-radiotherapy
#13
Tilman Bostel, Asja Pfaffenberger, Stefan Delorme, Constantin Dreher, Gernot Echner, Peter Haering, Clemens Lang, Mona Splinter, Frederik Laun, Marco Müller, Oliver Jäkel, Jürgen Debus, Peter E Huber, Florian Sterzing, Nils H Nicolay
BACKGROUND: The present work aimed to analyze the feasibility of a shuttle-based MRI-guided radiation therapy (MRgRT) in the treatment of pelvic malignancies. PATIENTS AND METHODS: 20 patients with pelvic malignancies were included in this prospective feasibility analysis. Patients underwent daily MRI in treatment position prior to radiotherapy at the German Cancer Research Center. Positional inaccuracies, time and patient compliance were assessed for the application of off-line MRgRT...
January 18, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29348825/a-novel-anti-cd146-antibody-specifically-targets-cancer-cells-by-internalizing-the-molecule
#14
Marie Nollet, Jimmy Stalin, Anaïs Moyon, Waël Traboulsi, Amel Essaadi, Stéphane Robert, Nausicaa Malissen, Richard Bachelier, Laurent Daniel, Alexandrine Foucault-Bertaud, Caroline Gaudy-Marqueste, Romaric Lacroix, Aurélie S Leroyer, Benjamin Guillet, Nathalie Bardin, Françoise Dignat-George, Marcel Blot-Chabaud
CD146 is an adhesion molecule present on many tumors (melanoma, kidney, pancreas, breast, ...). In addition, it has been shown to be expressed on vascular endothelial and smooth muscle cells. Generating an antibody able to specifically recognize CD146 in cancer cells (designated as tumor CD146), but not in normal cells, would thus be of major interest for targeting tumor CD146 without affecting the vascular system. We thus generated antibodies against the extracellular domain of the molecule produced in cancer cells and selected an antibody that specifically recognizes tumor CD146...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29348824/kca3-1-channel-inhibition-leads-to-an-icam-1-dependent-increase-of-cell-cell-adhesion-between-a549-lung-cancer-and-hmec-1-endothelial-cells
#15
Etmar Bulk, Nadzeya Kramko, Ivan Liashkovich, Felix Glaser, Hermann Schillers, Hans-Joachim Schnittler, Hans Oberleithner, Albrecht Schwab
Early metastasis leads to poor prognosis of lung cancer patients, whose 5-year survival rate is only 15%. We could recently show that the Ca2+ sensitive K+ channel KCa3.1 promotes aggressive behavior of non-small cell lung cancer (NSCLC) cells and that it can serve as a prognostic marker in NSCLC. Since NSCLC patients die of metastases, we investigated whether KCa3.1 channels contribute to poor patient prognosis by regulating distinct steps of the metastatic cascade. We investigated the extravasation of NSCLC cells and focused on their adhesion to endothelial cells and on transendothelial migration...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29348537/radionuclides-transform-chemotherapeutics-into-phototherapeutics-for-precise-treatment-of-disseminated-cancer
#16
Nalinikanth Kotagiri, Matthew L Cooper, Michael Rettig, Christopher Egbulefu, Julie Prior, Grace Cui, Partha Karmakar, Mingzhou Zhou, Xiaoxia Yang, Gail Sudlow, Lynne Marsala, Chantiya Chanswangphuwana, Lan Lu, LeMoyne Habimana-Griffin, Monica Shokeen, Xinming Xu, Katherine Weilbaecher, Michael Tomasson, Gregory Lanza, John F DiPersio, Samuel Achilefu
Most cancer patients succumb to disseminated disease because conventional systemic therapies lack spatiotemporal control of their toxic effects in vivo, particularly in a complicated milieu such as bone marrow where progenitor stem cells reside. Here, we demonstrate the treatment of disseminated cancer by photoactivatable drugs using radiopharmaceuticals. An orthogonal-targeting strategy and a contact-facilitated nanomicelle technology enabled highly selective delivery and co-localization of titanocene and radiolabelled fluorodeoxyglucose in disseminated multiple myeloma cells...
January 18, 2018: Nature Communications
https://www.readbyqxmd.com/read/29348411/in-vivo-microscopic-photoacoustic-spectroscopy-for-non-invasive-glucose-monitoring-invulnerable-to-skin-secretion-products
#17
Joo Yong Sim, Chang-Geun Ahn, Eun-Ju Jeong, Bong Kyu Kim
Photoacoustic spectroscopy has been shown to be a promising tool for non-invasive blood glucose monitoring. However, the repeatability of such a method is susceptible to changes in skin condition, which is dependent on hand washing and drying due to the high absorption of infrared excitation light to the skin secretion products or water. In this paper, we present a method to meet the challenges of mid-infrared photoacoustic spectroscopy for non-invasive glucose monitoring. By obtaining the microscopic spatial information of skin during the spectroscopy measurement, the skin region where the infrared spectra is insensitive to skin condition can be locally selected, which enables reliable prediction of the blood glucose level from the photoacoustic spectroscopy signals...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29348262/dawn-of-a-new-era-for-stroke-treatment-implications-of-the-dawn-study-for-acute-stroke-care-and-stroke-systems-of-care
#18
Mark J Alberts, Martin D Ollenschleger, Amre Nouh
Until recently, the selection of patients with large artery occlusion and ischemic stroke for reperfusion therapy was based on time criteria (typically within 6 hours) and basic imaging protocols (head CT, CT angiogram, ASPECTS score). The recently published DAWN (DWI or CTP Assessment with Clinical Mismatch in the Triage of Wake-Up and Late Presenting Strokes Undergoing Neurointervention with Trevo) study has changed this paradigm by using a tissue-based selection criteria and a greatly expanded treatment time window (up to 24 hours)...
January 18, 2018: Circulation
https://www.readbyqxmd.com/read/29348132/t2-relaxometry-mri-predicts-cerebral-palsy-in-preterm-infants
#19
L-W Chen, S-T Wang, C-C Huang, Y-F Tu, Y-S Tsai
BACKGROUND AND PURPOSE: T2-relaxometry brain MR imaging enables objective measurement of brain maturation based on the water-macromolecule ratio in white matter, but the outcome correlation is not established in preterm infants. Our study aimed to predict neurodevelopment with T2-relaxation values of brain MR imaging among preterm infants. MATERIALS AND METHODS: From January 1, 2012, to May 31, 2015, preterm infants who underwent both T2-relaxometry brain MR imaging and neurodevelopmental follow-up were retrospectively reviewed...
January 18, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29346832/diagnosis-of-lumbar-spinal-stenosis-with-functional-myelography
#20
Matthias Morgalla, Sandra Frantz, Roberto Alexandre Dezena, Carlos Umberto Pereira, Marcos Tatagiba
BACKGROUND AND STUDY AIMS:  The diagnosis of a lumbar spinal stenosis demands advanced diagnostic radiologic techniques. In recent decades magnetic resonance imaging (MRI) has replaced myelography, now considered an old-fashioned technique. It was our hypothesis that functional myelography still plays an important role in selected cases. We investigated how our surgical strategy was influenced by the results of MRI, functional myelography, and postmyelography computed tomography (CT) in patients with a lumbar spinal stenosis...
January 18, 2018: Journal of Neurological Surgery. Part A, Central European Neurosurgery
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