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https://www.readbyqxmd.com/read/28735051/telavancin-activity-in-vitro-tested-against-a-worldwide-collection-of-gram-positive-clinical-isolates-2014
#1
Leonard R Duncan, Helio S Sader, Jennifer I Smart, Robert K Flamm, Rodrigo E Mendes
OBJECTIVES: Telavancin activity was measured against Gram-positive pathogens collected worldwide during 2014 using the revised broth microdilution testing method. The results were compared with previous reports. METHODS: A total of 10 552 isolates from 86 sites located in 32 countries were included as part of the Telavancin International Surveillance Program for the Americas, Europe and Asia-Pacific. RESULTS: Telavancin had MIC50 and MIC90 values of 0...
July 19, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28733868/impact-of-age-on-the-risk-of-advanced-colorectal-neoplasia-in-a-young-population-an-analysis-using-the-predicted-probability-model
#2
Yoon Suk Jung, Chan Hyuk Park, Nam Hee Kim, Mi Yeon Lee, Dong Il Park
BACKGROUND: The incidence of colorectal cancer is decreasing in adults aged ≥50 years and increasing in those aged <50 years. AIMS: We aimed to establish risk stratification model for advanced colorectal neoplasia (ACRN) in persons aged <50 years. METHODS: We reviewed the records of participants who had undergone a colonoscopy as part of a health examination at two large medical examination centers in Korea. By using logistic regression analysis, we developed predicted probability models for ACRN in a population aged 30-49 years...
July 21, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28732354/influence-of-body-mass-index-on-postoperative-complications-after-thymectomy-in-myasthenia-gravis-patients
#3
Xu-Dong Liu, Ming-Rui Shao, Lei Sun, Lin Zhang, Xin-Shan Jia, Wen-Ya Li
OBJECTIVES: It is not clear whether being overweight or obese influences postoperative complications in myasthenia gravis (MG) patients. We retrospectively investigated an association between body mass index (BMI) and postoperative complications in MG. MATERIALS AND METHODS: Fifty-nine MG patients who had undergone transsternal thymectomy were classified as low or high BMI based on the criteria for Asian-Pacific populations. An association between BMI and complications was analyzed...
July 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28732070/characterization-of-human-enterovirus71-virus-like-particles-used-for-vaccine-antigens
#4
Dandan Zhao, Bo Sun, Shiyang Sun, Bin Fu, Chuntian Liu, Dawei Liu, Yanfei Chu, Youlei Ma, Lu Bai, Yongge Wu, Yan Zhou, Weiheng Su, Ali Hou, Linjun Cai, Fei Xu, Wei Kong, Chunlai Jiang
Human enterovirus 71 (EV71) is a major causative pathogen of hand, foot and mouth disease (HFMD) and has caused outbreaks with significant mortality among young children in the Asia-Pacific region in recent years. Towards developing a vaccine for this disease, we have expressed and purified EV71 virus-like particles (VLPs), which resemble the authentic virus in appearance, capsid structure and protein sequence, from insect cells (Sf9) using a multistep chromatography process. We demonstrated intracellular localization of the VLPs in host cells by in situ immunogold detection, electron microscopy and immunofluorescence...
2017: PloS One
https://www.readbyqxmd.com/read/28730805/integrating-discovery-driven-proteomics-and-selected-reaction-monitoring-to-develop-a-non-invasive-assay-for-geoduck-reproductive-maturation
#5
Emma B Timmins-Schiffman, Grace A Crandall, Brent Vadopalas, Michael E Riffle, Brook L Nunn, Steven Roberts
Geoduck clams (Panopea generosa) are an increasingly important fishery and aquaculture product along the eastern Pacific coast from Baja California, Mexico to Alaska. These long-lived clams are highly fecund, though sustainable hatchery production of genetically diverse larvae is hindered by the lack of sexual dimorphism, resulting in asynchronous spawning of broodstock, unequal sex ratios, and low numbers of breeders. Development of assays of gonad physiology could indicate sex and maturation stage, as well as be used to assess the status of natural populations...
July 21, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28729854/microbiome-of-trichodesmium-colonies-from-the-north-pacific-subtropical-gyre
#6
Mary R Gradoville, Byron C Crump, Ricardo M Letelier, Matthew J Church, Angelicque E White
Filamentous diazotrophic Cyanobacteria of the genus Trichodesmium, often found in colonial form, provide an important source of new nitrogen to tropical and subtropical marine ecosystems. Colonies are composed of several clades of Trichodesmium in association with a diverse community of bacterial and eukaryotic epibionts. We used high-throughput 16S rRNA and nifH gene sequencing, carbon (C) and dinitrogen (N2) fixation assays, and metagenomics to describe the diversity and functional potential of the microbiome associated with Trichodesmium colonies collected from the North Pacific Subtropical Gyre (NPSG)...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28729681/multiomics-analysis-of-the-giant-triton-snail-salivary-gland-a-crown-of-thorns-starfish-predator
#7
U Bose, T Wang, M Zhao, C A Motti, M R Hall, S F Cummins
The giant triton snail (Charonia tritonis) is one of the few natural predators of the adult Crown-of-Thorns starfish (COTS), a corallivore that has been damaging to many reefs in the Indo-Pacific. Charonia species have large salivary glands (SGs) that are suspected to produce either a venom and/or sulphuric acid which can immobilize their prey and neutralize the intrinsic toxic properties of COTS. To date, there is little information on the types of toxins produced by tritons. In this paper, the predatory behaviour of the C...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28729611/cryptic-speciation-in-pan-tropical-sea-urchins-a-case-study-of-an-edge-of-range-population-of-tripneustes-from-the-kermadec-islands
#8
Omri Bronstein, Andreas Kroh, Barbara Tautscher, Libby Liggins, Elisabeth Haring
Tripneustes is one of the most abundant and ecologically significant tropical echinoids. Highly valued for its gonads, wild populations of Tripneustes are commercially exploited and cultivated stocks are a prime target for the fisheries and aquaculture industry. Here we examine Tripneustes from the Kermadec Islands, a remote chain of volcanic islands in the southwest Pacific Ocean that mark the boundary of the genus' range, by combining morphological and genetic analyses, using two mitochondrial (COI and the Control Region), and one nuclear (bindin) marker...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28729610/mean-bias-in-seasonal-forecast-model-and-enso-prediction-error
#9
Seon Tae Kim, Hye-In Jeong, Fei-Fei Jin
This study uses retrospective forecasts made using an APEC Climate Center seasonal forecast model to investigate the cause of errors in predicting the amplitude of El Niño Southern Oscillation (ENSO)-driven sea surface temperature variability. When utilizing Bjerknes coupled stability (BJ) index analysis, enhanced errors in ENSO amplitude with forecast lead times are found to be well represented by those in the growth rate estimated by the BJ index. ENSO amplitude forecast errors are most strongly associated with the errors in both the thermocline slope response and surface wind response to forcing over the tropical Pacific, leading to errors in thermocline feedback...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28729520/challenges-and-emerging-opportunities-for-the-hiv-prevention-treatment-and-care-cascade-in-men-who-have-sex-with-men-in-asia-pacific
#10
REVIEW
Frits van Griensven, Thomas E Guadamuz, Jan Willem de Lind van Wijngaarden, Nittaya Phanuphak, Sunil Suhas Solomon, Ying-Ru Lo
In Asia Pacific, most countries have expanded HIV treatment guidelines to include all those with HIV infection and adopted antiretroviral treatment for prevention (TFP) as a blanket strategy for HIV control. Although the overall epidemic development associated with this focus is positive, the HIV epidemic in men who have sex with men (MSM) is continuing unperturbed without any signs of decline or reversal. This raises doubt about whether TFP as a blanket HIV prevention policy is the right approach. This paper reviews currently available biomedical HIV prevention strategies, national HIV prevention policies and guidelines from selected countries and published data on the HIV cascade in MSM...
August 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28728956/ataluren-in-patients-with-nonsense-mutation-duchenne-muscular-dystrophy-act-dmd-a-multicentre-randomised-double-blind-placebo-controlled-phase-3-trial
#11
Craig M McDonald, Craig Campbell, Ricardo Erazo Torricelli, Richard S Finkel, Kevin M Flanigan, Nathalie Goemans, Peter Heydemann, Anna Kaminska, Janbernd Kirschner, Francesco Muntoni, Andrés Nascimento Osorio, Ulrike Schara, Thomas Sejersen, Perry B Shieh, H Lee Sweeney, Haluk Topaloglu, Már Tulinius, Juan J Vilchez, Thomas Voit, Brenda Wong, Gary Elfring, Hans Kroger, Xiaohui Luo, Joseph McIntosh, Tuyen Ong, Peter Riebling, Marcio Souza, Robert J Spiegel, Stuart W Peltz, Eugenio Mercuri
BACKGROUND: Duchenne muscular dystrophy (DMD) is a severe, progressive, and rare neuromuscular, X-linked recessive disease. Dystrophin deficiency is the underlying cause of disease; therefore, mutation-specific therapies aimed at restoring dystrophin protein production are being explored. We aimed to assess the efficacy and safety of ataluren in ambulatory boys with nonsense mutation DMD. METHODS: We did this multicentre, randomised, double-blind, placebo-controlled, phase 3 trial at 54 sites in 18 countries located in North America, Europe, the Asia-Pacific region, and Latin America...
July 17, 2017: Lancet
https://www.readbyqxmd.com/read/28728634/prospective-effects-of-parenting-on-substance-use-and-problems-across-asian-pacific-islander-and-european-american-youth-tests-of-moderated-mediation
#12
Jeremy W Luk, Kevin M King, Carolyn A McCarty, Elizabeth McCauley, Ann Vander Stoep
OBJECTIVE: Parental warmth and knowledge are protective factors against substance use, whereas parental psychological control is a risk factor. However, the interpretation of parenting and its effects on developmental outcomes may vary cross-culturally. This study examined direct and indirect effects of three parenting dimensions on substance use across Asian/Pacific Islander (API) and European Americans. METHOD: A community sample of 97 API and 255 European Americans were followed from Grades 6 to 12...
July 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/28727726/a-cross-sectional-seroepidemiological-survey-of-typhoid-fever-in-fiji
#13
Conall H Watson, Stephen Baker, Colleen L Lau, Kitione Rawalai, Mere Taufa, Jerimaia Coriakula, Nga Tran Vu Thieu, Tan Trinh Van, Dung Tran Thi Ngoc, Niel Hens, John Lowry, Ruklanthi de Alwis, Jorge Cano, Kylie Jenkins, E Kim Mulholland, Eric J Nilles, Mike Kama, W John Edmunds
Fiji, an upper-middle income state in the Pacific Ocean, has experienced an increase in confirmed case notifications of enteric fever caused by Salmonella enterica serovar Typhi (S. Typhi). To characterize the epidemiology of typhoid exposure, we conducted a cross-sectional sero-epidemiological survey measuring IgG against the Vi antigen of S. Typhi to estimate the effect of age, ethnicity, and other variables on seroprevalence. Epidemiologically relevant cut-off titres were established using a mixed model analysis of data from recovering culture-confirmed typhoid cases...
July 20, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28727690/demographic-and-psychological-correlates-of-satisfaction-with-healthcare-access-in-new-zealand
#14
Carol Hj Lee, Chris G Sibley
AIMS: To explore the distribution of New Zealanders' satisfaction with their healthcare access and identify various demographic and psychological factors associated with this satisfaction. METHODS: 15,822 participants responded to the 2014/15 New Zealand Attitudes and Values Study (NZAVS) survey. This survey included questions on participants' demographic and psychological characteristics, and an item asking for their level of satisfaction with "your access to healthcare when you need it"...
July 21, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28726397/potential-releases-of-129-i-236-u-and-pu-isotopes-from-the-fukushima-dai-ichi-nuclear-power-plants-to-the-ocean-during-2013-to-2015
#15
Núria Casacuberta, Marcus Christl, Ken O Buesseler, YikSze Lau, Christof Vockenhuber, Maxi Castrillejo, Hans-Arno Synal, Pere Masque
After the Fukushima Dai-ichi Nuclear accident, many efforts were put into the determination of the presence of (137)Cs, (134)Cs, (131)I and other gamma-emitting radionuclides in the ocean, but minor work was done regarding the monitoring of less volatile radionuclides, pure beta-ray emitters or simply radionuclides with very long half-lives. In this study we document the temporal evolution of (129)I, (236)U and Pu isotopes ((239)Pu and (240)Pu) in seawater sampled during four different cruises performed 2, 3 and 4 years after the accident, and compare the results to (137)Cs collected at the same stations and depths...
July 20, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28726124/diversity-of-culturable-filamentous-ascomycetes-in-the-eastern-south-pacific-ocean-off-chile
#16
Jeanett Vera, Marcelo H Gutiérrez, Götz Palfner, Silvio Pantoja
Our study reports the diversity of culturable mycoplankton in the eastern South Pacific Ocean off Chile to contribute with novel knowledge on taxonomy of filamentous fungi isolated from distinct physicochemical and biological marine environments. We characterized spatial distribution of isolates, evaluated their viability and assessed the influence of organic substrate availability on fungal development. Thirty-nine Operational Taxonomic Units were identified from 99 fungal strains isolated from coastal and oceanic waters by using Automatic Barcode Gap Discovery...
August 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28725397/genetic-diversity-and-phylogeography-of-siberian-roe-deer-caproulus-pygargus-in-central-and-peripheral-populations
#17
Yun Sun Lee, Nickolay Markov, Alexander Argunov, Inna Voloshina, Damdingiin Bayarlkhagva, Baek-Jun Kim, Mi-Sook Min, Hang Lee, Kyung Seok Kim
Current understanding of phylogeographical structure and genetic diversity of Siberian roe deer remains limited mainly due to small sample size and/or low geographical coverage in previous studies. Published data suggest at least two phylogroups: western (Ural Mountains and Western Siberia) and eastern (east from lake Baikal, including the Korean peninsula), but their phylogenetic relationship remains unclear. Combined sequences of cytochrome b (1140 bp) and the mtDNA control region (963 bp) were analyzed from 219 Siberian roe deer from 12 locations in Russia, Mongolia, and South Korea, which cover a large part of its range, to assess genetic diversity and phylogeographical status...
October 2016: Ecology and Evolution
https://www.readbyqxmd.com/read/28725011/observed-trends-in-the-magnitude-and-persistence-of-monthly-temperature-variability
#18
Timothy M Lenton, Vasilis Dakos, Sebastian Bathiany, Marten Scheffer
Climate variability is critically important for nature and society, especially if it increases in amplitude and/or fluctuations become more persistent. However, the issues of whether climate variability is changing, and if so, whether this is due to anthropogenic forcing, are subjects of ongoing debate. Increases in the amplitude and persistence of temperature fluctuations have been detected in some regions, e.g. the North Pacific, but there is no agreed global signal. Here we systematically scan monthly surface temperature indices and spatial datasets to look for trends in variance and autocorrelation (persistence)...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28724896/unprecedented-drought-over-tropical-south-america-in-2016-significantly-under-predicted-by-tropical-sst
#19
Amir Erfanian, Guiling Wang, Lori Fomenko
Tropical and sub-tropical South America are highly susceptible to extreme droughts. Recent events include two droughts (2005 and 2010) exceeding the 100-year return value in the Amazon and recurrent extreme droughts in the Nordeste region, with profound eco-hydrological and socioeconomic impacts. In 2015-2016, both regions were hit by another drought. Here, we show that the severity of the 2015-2016 drought ("2016 drought" hereafter) is unprecedented based on multiple precipitation products (since 1900), satellite-derived data on terrestrial water storage (since 2002) and two vegetation indices (since 2004)...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28724734/hydrothermal-vent-fields-discovered-in-the-southern-gulf-of-california-clarify-role-of-habitat-in-augmenting-regional-diversity
#20
Shana K Goffredi, Shannon Johnson, Verena Tunnicliffe, David Caress, David Clague, Elva Escobar, Lonny Lundsten, Jennifer B Paduan, Greg Rouse, Diana L Salcedo, Luis A Soto, Ronald Spelz-Madero, Robert Zierenberg, Robert Vrijenhoek
Hydrothermal vent communities are distributed along mid-ocean spreading ridges as isolated patches. While distance is a key factor influencing connectivity among sites, habitat characteristics are also critical. The Pescadero Basin (PB) and Alarcón Rise (AR) vent fields, recently discovered in the southern Gulf of California, are bounded by previously known vent localities (e.g. Guaymas Basin and 21° N East Pacific Rise); yet, the newly discovered vents differ markedly in substrata and vent fluid attributes...
July 26, 2017: Proceedings. Biological Sciences
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