Ahmed AlBadri, Janet Wei, Odayme Quesada, Puja K Mehta, Yi Xiao, Yi-An Ko, R David Anderson, John Petersen, Babak Azarbal, Bruce Samuels, Timothy D Henry, Galen Cook-Wiens, Eileen M Handberg, Jennifer Van Eyk, Carl J Pepine, C Noel Bairey Merz
OBJECTIVE: Women with symptoms or signs of myocardial ischemia but no obstructive coronary artery disease (INOCA) often have coronary vascular dysfunction and elevated risk for adverse cardiovascular events. We hypothesized that u-hscTnI (ultra-high-sensitivity cardiac troponin I), a sensitive indicator of ischemic cardiomyocyte injury, is associated with coronary vascular dysfunction in women with INOCA. Approach and Results: Women (N=263) with INOCA enrolled in the WISE-CVD study (Women's Ischemic Syndrome Evaluation-Coronary Vascular Dysfunction) underwent invasive coronary vascular function testing and u-hscTnI measurements (Simoa HD-1 Analyzer; Quanterix Corporation, Lexington, MA)...
October 8, 2020: Arteriosclerosis, Thrombosis, and Vascular Biology