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gene-diet interaction

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https://www.readbyqxmd.com/read/28819233/biology-physiology-and-gene-expression-of-grasshopper-oedaleus-asiaticus-exposed-to-diet-stress-from-plant-secondary-compounds
#1
Xunbing Huang, Jingchuan Ma, Xinghu Qin, Xiongbing Tu, Guangchun Cao, Guangjun Wang, Xiangqun Nong, Zehua Zhang
We studied the role of plant primary and secondary metabolites in mediating plant-insect interactions by conducting a no-choice single-plant species field experiment to compare the suitability, enzyme activities, and gene expression of Oedaleus asiaticus grasshoppers feeding on four host and non-host plants with different chemical traits. O. asiaticus growth showed a positive relationship to food nutrition content and a negative relationship to secondary compounds content. Grasshopper amylase, chymotrypsin, and lipase activities were positively related to food starch, crude protein, and lipid content, respectively...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811369/obesity-associated-gene-tmem18-has-a-role-in-the-central-control-of-appetite-and-body-weight-regulation
#2
Rachel Larder, M F Michelle Sim, Pawan Gulati, Robin Antrobus, Y C Loraine Tung, Debra Rimmington, Eduard Ayuso, Joseph Polex-Wolf, Brian Y H Lam, Cristina Dias, Darren W Logan, Sam Virtue, Fatima Bosch, Giles S H Yeo, Vladimir Saudek, Stephen O'Rahilly, Anthony P Coll
An intergenic region of human chromosome 2 (2p25.3) harbors genetic variants which are among those most strongly and reproducibly associated with obesity. The gene closest to these variants is TMEM18, although the molecular mechanisms mediating these effects remain entirely unknown. Tmem18 expression in the murine hypothalamic paraventricular nucleus (PVN) was altered by changes in nutritional state. Germline loss of Tmem18 in mice resulted in increased body weight, which was exacerbated by high fat diet and driven by increased food intake...
August 15, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28795659/role-of-mycotoxins-in-the-pathobiology-of-autism-a-first-evidence
#3
Barbara De Santis, Carlo Brera, Alessandra Mezzelani, Sabina Soricelli, Francesca Ciceri, Giorgio Moretti, Francesca Debegnach, Maria Clara Bonaglia, Laura Villa, Massimo Molteni, Maria Elisabetta Raggi
OBJECTIVES: Gene-environment interaction is an emerging hypothesis to expound not only the autism pathogenesis but also the increased incidence of neurodevelopmental disorders (such as autistic spectrum disorder, attention-deficit, hyperactivity disorder). Among xenobiotics, mycotoxins are worldwide contaminants of food that provoke toxicological effects, crucially resembling several symptoms associated with autism such as oxidative stress, intestinal permeability, and inflammation. Here, we focused on a group of mycotoxins to test their role in the manifestation of autism, try to explain their mechanism of action, and discuss possible preventive and therapeutic interventions...
August 10, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28794922/molecular-characterization-of-eccipk24-gene-of-finger-millet-eleusine-coracana-for-investigating-its-regulatory-role-in-calcium-transport
#4
Mahadev Chinchole, Rajesh Kumar Pathak, Uma M Singh, Anil Kumar
Finger millet grains contain exceptionally high levels of calcium which is much higher compared to other cereals and millets. Since calcium is an important macronutrient in human diet, it is necessary to explore the molecular basis of calcium accumulation in the seeds of finger millet. CIPK is a calcium sensor gene, having role in activating Ca(2+) exchanger protein by interaction with CBL proteins. To know the role of EcCIPK24 gene in seed Ca(2+) accumulation, sequence is retrieved from the transcriptome data of two finger millet genotypes GP1 (low Ca(2+)) and GP45 (high Ca(2+)), and the expression was determined through qRT-PCR...
August 2017: 3 Biotech
https://www.readbyqxmd.com/read/28792546/host-plant-driven-transcriptome-plasticity-in-the-salivary-glands-of-the-cabbage-looper-trichoplusia-ni
#5
Loren J Rivera-Vega, David A Galbraith, Christina M Grozinger, Gary W Felton
Generalist herbivores feed on a wide array of plants and need to adapt to varying host qualities and defenses. One of the first insect derived secretions to come in contact with the plant is the saliva. Insect saliva is potentially involved in both the pre-digestion of the host plant as well as induction/suppression of plant defenses, yet how the salivary glands respond to changes in host plant at the transcriptional level is largely unknown. The objective of this study was to determine how the labial salivary gland transcriptome varies according to the host plant on which the insect is feeding...
2017: PloS One
https://www.readbyqxmd.com/read/28792482/association-and-interaction-effect-of-agtr1-and-agtr2-gene-polymorphisms-with-dietary-pattern-on-metabolic-risk-factors-of-cardiovascular-disease-in-malaysian-adults
#6
Roseline Wai Kuan Yap, Yoshihiro Shidoji, Wai Sum Yap, Motofumi Masaki
Gene-diet interaction using a multifactorial approach is preferred to study the multiple risk factors of cardiovascular disease (CVD). This study examined the association and gene-diet interaction effects of the angiotensin II type 1 receptor (AGTR1) gene (rs5186), and type 2 receptor (AGTR2) gene (rs1403543) polymorphisms on metabolic risk factors of CVD in Malaysian adults. CVD parameters (BMI, blood pressure, glycated hemoglobin, total cholesterol (TC), triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C), and TC/HDL-C ratio), and constructed dietary patterns "vegetables, fruits, and soy diet" (VFSD), and "rice, egg, and fish diet" (REFD) were obtained from previous studies...
August 9, 2017: Nutrients
https://www.readbyqxmd.com/read/28790932/the-effects-of-weaning-methods-on-gut-microbiota-composition-and-horse-physiology
#7
Núria Mach, Aline Foury, Sandra Kittelmann, Fabrice Reigner, Marco Moroldo, Maria Ballester, Diane Esquerré, Julie Rivière, Guillaume Sallé, Philippe Gérard, Marie-Pierre Moisan, Léa Lansade
Weaning has been described as one of the most stressful events in the life of horses. Given the importance of the interaction between the gut-brain axis and gut microbiota under stress, we evaluated (i) the effect of two different weaning methods on the composition of gut microbiota across time and (ii) how the shifts of gut microbiota composition after weaning affect the host. A total of 34 foals were randomly subjected to a progressive (P) or an abrupt (A) weaning method. In the P method, mares were separated from foals at progressively increasing intervals every day, starting from five min during the fourth week prior to weaning and ending with 6 h during the last week before weaning...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28790160/card9-mediates-susceptibility-to-intestinal-pathogens-through-microbiota-modulation-and-control-of-bacterial-virulence
#8
Bruno Lamas, Marie-Laure Michel, Nadine Waldschmitt, Hang-Phuong Pham, Vassiliki Zacharioudaki, Louise Dupraz, Myriam Delacre, Jane M Natividad, Gregory Da Costa, Julien Planchais, Bruno Sovran, Chantal Bridonneau, Adrien Six, Philippe Langella, Mathias L Richard, Mathias Chamaillard, Harry Sokol
OBJECTIVE: In association with innate and adaptive immunity, the microbiota controls the colonisation resistance against intestinal pathogens. Caspase recruitment domain 9 (CARD9), a key innate immunity gene, is required to shape a normal gut microbiota. Card9(-/-) mice are more susceptible to the enteric mouse pathogen Citrobacter rodentium that mimics human infections with enteropathogenic and enterohaemorrhagic Escherichia coli. Here, we examined how CARD9 controls C. rodentium infection susceptibility through microbiota-dependent and microbiota-independent mechanisms...
August 8, 2017: Gut
https://www.readbyqxmd.com/read/28789970/mitochondrial-fusion-fission-and-mitochondrial-toxicity
#9
Joel N Meyer, Tess C Leuthner, Anthony L Luz
Mitochondrial dynamics are regulated by two sets of opposed processes: mitochondrial fusion and fission, and mitochondrial biogenesis and degradation (including mitophagy), as well as processes such as intracellular transport. These processes maintain mitochondrial homeostasis, regulate mitochondrial form, volume and function, and are increasingly understood to be critical components of the cellular stress response. Mitochondrial dynamics vary based on developmental stage and age, cell type, environmental factors, and genetic background...
August 5, 2017: Toxicology
https://www.readbyqxmd.com/read/28783736/glutamate-alleviates-muscle-protein-loss-by-modulating-tlr4-nods-akt-foxo-and-mtor-signaling-pathways-in-lps-challenged-piglets
#10
Ping Kang, Xiuying Wang, Huanting Wu, Huiling Zhu, Yongqing Hou, Longmei Wang, Yulan Liu
The experiment was conducted to study the effect of the glutamate (Glu) on muscle protein loss through toll-like receptor 4 (TLR4), nucleotide-binding oligomerization domain proteins (NODs), Akt/Forkhead Box O (Akt/FOXO) and mammalian target of rapamycin (mTOR) signaling pathways in LPS-challenged piglets. Twenty-four weaned piglets were assigned into four treatments: (1) Control; (2) LPS+0% Glu; (3) LPS + 1.0% Glu; (4) LPS + 2.0% Glu. The experiment was lasted for 28 days. On d 28, the piglets in the LPS challenged groups were injected with LPS on 100 μg/kg body weight (BW), and the piglets in the control group were injected with the same volume of 0...
2017: PloS One
https://www.readbyqxmd.com/read/28783600/selenium-antagonizes-cadmium-induced-apoptosis-in-chicken-spleen-but-not-involving-nrf2-regulated-antioxidant-response
#11
Menghao Chen, Xiaojing Li, Ruifeng Fan, Changyu Cao, Haidong Yao, Shiwen Xu
The nuclear transcription factor NF-E2-related factor 2 (Nrf2) binds to antioxidant response elements (AREs) and is involved in the regulation of genes participated in defending cells against oxidative damage, which have been confirmed in animal models. Selenium (Se), known as an important element in the regulation of antioxidant activity, can antagonize Cadmium (Cd) toxicity in birds. However, the role of Nrf2 in selenium-cadmium interaction has not been reported in birds. To further explore the mechanism of selenium attenuating spleen toxicity induced by cadmium in chickens, cadmium chloride (CdCl2, 150mg/kg) and sodium selenite (Na2SeO3, 2mg/kg) were co-administrated or individually administered in the diet of chickens for 90 days...
August 4, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28774683/dietary-linoleic-acid-interacts-with-fads1-genetic-variability-to-modulate-hdl-cholesterol-and-obesity-related-traits
#12
Julie Dumont, Louisa Goumidi, Benjamin Grenier-Boley, Dominique Cottel, Nadine Marécaux, Michèle Montaye, Aline Wagner, Dominique Arveiler, Chantal Simon, Jean Ferrières, Jean-Bernard Ruidavets, Philippe Amouyel, Jean Dallongeville, Aline Meirhaeghe
BACKGROUND & AIMS: Blood levels of polyunsaturated fatty acids (PUFAs) are under control of endogenous synthesis via Δ5- and Δ6-desaturases, encoded by the FADS1 and FADS2 genes, respectively and of diet. Genome-wide associations studies (GWAS) reported associations between polymorphisms in FADS1-FADS2 and variations in plasma concentrations of PUFAs, HDL- and LDL-cholesterol and triglycerides. However, it is not established whether dietary PUFAs intake modulates these associations...
July 20, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28768654/effect-of-the-interaction-between-diet-composition-and-the-ppm1k-genetic-variant-on-insulin-resistance-and-%C3%AE-cell-function-markers-during-weight-loss-results-from-the-nutrient-gene-interactions-in-human-obesity-implications-for-dietary-guidelines-nugenob-randomized
#13
Leticia Goni, Lu Qi, Marta Cuervo, Fermín I Milagro, Wim H Saris, Ian A MacDonald, Dominique Langin, Arne Astrup, Peter Arner, Jean-Michel Oppert, Mathilde Svendstrup, Ellen E Blaak, Thorkild Ia Sørensen, Torben Hansen, J Alfredo Martínez
Background: Circulating branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs) have been shown to be associated with insulin resistance and diabetes risk. The common rs1440581 T allele in the protein phosphatase Mg2+/Mn2+ dependent 1K (PPM1K) gene has been related to elevated BCAA concentrations and risk of type 2 diabetes.Objective: In the present study, we tested whether dietary fat and carbohydrate intakes influenced the association between the rs1440581 PPM1K genetic variant and glucose-metabolism traits during weight loss...
August 2, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28768569/tissue-cell-stress-response-to-obesity-and-its-interaction-with-late-gestation-diet
#14
Vivek Saroha, Neele S Dellschaft, Duane H Keisler, David S Gardner, Helen Budge, Sylvain P Sebert, Michael E Symonds
Intrauterine growth restriction in late pregnancy can contribute to adverse long-term metabolic health in the offspring. In the present study we used an animal (sheep) model of maternal dietary manipulation in late pregnancy, combined with exposure of the offspring to a low-activity, obesogenic environment after weaning, to characterise the effects on glucose homeostasis. Dizygotic twin-pregnant sheep were either fed to 60% of requirements (nutrient restriction (R)) or fed ad libitum (~140% of requirements (A)) from 110 days gestation until term (~147 days)...
August 3, 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/28762001/high-grain-diets-altered-rumen-fermentation-and-epithelial-bacterial-community-and-resulted-in-rumen-epithelial-injuries-of-goats
#15
Ruiyang Zhang, Huimin Ye, Junhua Liu, Shengyong Mao
This study evaluated the effects of high-grain diets on the rumen fermentation, epithelial bacterial community, morphology of rumen epithelium, and local inflammation of goats during high-grain feeding. Twelve 8-month-old goats were randomly assigned to two different diets, a hay diet or a high-grain diet (65% grain, HG). At the end of 7 weeks of treatment, samples of rumen content and rumen epithelium were collected. Rumen pH was lower (P < 0.05), but the levels of volatile fatty acids and lipopolysaccharides were higher (P < 0...
August 1, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28761824/the-effect-of-dried-glycyrrhiza-glabra-l-extract-on-obesity-management-with-regard-to-ppar-%C3%AE-2-pro12ala-gene-polymorphism-in-obese-subjects-following-an-energy-restricted-diet
#16
Nazli Namazi, Mohammad Alizadeh, Elham Mirtaheri, Safar Farajnia
Purpose: Obesity is a multi-factorial health problem which results from the interaction of environmental and genetic factors. The aim of the present study was to determine the effects of dried licorice extract with a calorie restricted diet on anthropometric indices and insulin resistance with nutrigenetic approach. Methods: For this pilot, double-blind, placebo-controlled randomized clinical trial, 72 eligible subjects were randomly allocated to Licorice or placebo group. They received a low-calorie diet either with a 1...
June 2017: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28761062/t2diacod-a-gene-atlas-of-type-2-diabetes-mellitus-associated-complex-disorders
#17
Jyoti Rani, Inna Mittal, Atreyi Pramanik, Namita Singh, Namita Dube, Smriti Sharma, Bhanwar Lal Puniya, Muthukurussi Varieth Raghunandanan, Ahmed Mobeen, Srinivasan Ramachandran
We performed integrative analysis of genes associated with type 2 Diabetes Mellitus (T2DM) associated complications by automated text mining with manual curation and also gene expression analysis from Gene Expression Omnibus. They were analysed for pathogenic or protective role, trends, interaction with risk factors, Gene Ontology enrichment and tissue wise differential expression. The database T2DiACoD houses 650 genes, and 34 microRNAs associated with T2DM complications. Seven genes AGER, TNFRSF11B, CRK, PON1, ADIPOQ, CRP and NOS3 are associated with all 5 complications...
July 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28757641/education-as-a-moderator-of-genetic-risk-for-higher-body-mass-index-prospective-cohort-study-from-childhood-to-adulthood
#18
K Komulainen, L Pulkki-Råback, M Jokela, L-P Lyytikäinen, N Pitkänen, T Laitinen, M Hintsanen, M Elovainio, T Hintsa, A Jula, M Juonala, K Pahkala, J Viikari, T Lehtimäki, O Raitakari, L Keltikangas-Järvinen
OBJECTIVES: The life-course development of body mass index (BMI) may be driven by interactions between genes and obesity-inducing social environments. We examined whether lower parental or own education accentuates the genetic risk for higher BMI over the life course, and whether diet and physical activity account for the educational differences in genetic associations with BMI. SUBJECTS/METHODS: The study comprised 2441 participants (1319 women, 3-18 years at baseline) from the prospective, population-based Cardiovascular Risk in Young Finns Study...
July 31, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28757615/ror%C3%AE-controls-hepatic-lipid-homeostasis-via-negative-regulation-of-ppar%C3%AE-transcriptional-network
#19
Kyeongkyu Kim, Kyungjin Boo, Young Suk Yu, Se Kyu Oh, Hyunkyung Kim, Yoon Jeon, Jinhyuk Bhin, Daehee Hwang, Keun Il Kim, Jun-Su Lee, Seung-Soon Im, Seul Gi Yoon, Il Yong Kim, Je Kyung Seong, Ho Lee, Sungsoon Fang, Sung Hee Baek
The retinoic acid receptor-related orphan receptor-α (RORα) is an important regulator of various biological processes, including cerebellum development, circadian rhythm and cancer. Here, we show that hepatic RORα controls lipid homeostasis by negatively regulating transcriptional activity of peroxisome proliferators-activated receptor-γ (PPARγ) that mediates hepatic lipid metabolism. Liver-specific Rorα-deficient mice develop hepatic steatosis, obesity and insulin resistance when challenged with a high-fat diet (HFD)...
July 31, 2017: Nature Communications
https://www.readbyqxmd.com/read/28750406/a-high-fat-diet-during-pregnancy-and-lactation-induces-cardiac-and-renal-abnormalities-in-glut4-male-mice
#20
Michael Kruse, Ariana Fiallo, Jianling Tao, Katalin Susztak, Kerstin Amann, Ellen B Katz, Maureen J Charron
BACKGROUND/AIMS: Altered nutrients during the in utero (IU) and/or lactation (L) period predispose offspring to cardio-renal diseases in adulthood. This study investigates the effect of a high fat diet (HFD) fed to female mice during IU/L on gene expression patterns associated with heart and kidney failure and hypertension in male offspring. METHODS: Female wild type (WT) mice were fed either a HFD or control chow (C) prior to mating with males with a genetic heterozygous deletion of GLUT4 (G4+/-, a model of peripheral insulin resistance and hypertension) and throughout IU/L...
July 27, 2017: Kidney & Blood Pressure Research
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