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gene-diet interaction

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https://www.readbyqxmd.com/read/28527800/from-pre-to-postweaning-transformation-of-the-young-calf-s-gastrointestinal-tract
#1
Sarah J Meale, Frederique Chaucheyras-Durand, Harma Berends, Le Luo Guan, Michael A Steele
The ruminant gastrointestinal tract (GIT) faces the challenge of protecting the host from luminal contents and pathogens, while supporting the absorption and metabolism of nutrients for growth and maintenance. The GIT of the calf in early life undergoes some of the most rapid microbial and structural changes documented in nature, and these adaptations in GIT function make the young calf susceptible to GIT diseases and disorders. Despite these challenges, the calf's GIT has a certain degree of plasticity and can sense nutrient supply and respond to bioactive ingredients...
May 17, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28521687/diet-and-contaminants-driving-the-rise-to-obesity-epidemics
#2
Agostino Di Ciaula, Piero Portincasa
The obesity epidemic is spreading worldwide without reversal trend and despite specific policies oriented to dietary habits and lifestyle, which seem to have modest effects. Genetic factors only partly explain the rise, whereas environmental factors seem to play a key role, mainly by gene-environment interactions through epigenetic mechanisms. A number of animal and human studies point to maternal diet, intestinal microbiota and chemicals introduced as contaminants with food, all factors able to increase the risk of obesity...
May 17, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28515069/mendelian-randomization-shows-sex-specific-associations-between-long-chain-pufa-related-genotypes-and-cognitive-performance-in-danish-schoolchildren
#3
Lotte Lauritzen, Louise B Sørensen, Laurine B Harsløf, Christian Ritz, Ken D Stark, Arne Astrup, Camilla B Dyssegaard, Niels Egelund, Kim F Michaelsen, Camilla T Damsgaard
Background: Dietary and endogenously formed long-chain polyunsaturated fatty acids (LCPUFAs) are hypothesized to improve cognitive development, but results are inconclusive, with suggestions of sex specificity. One study suggested that single-nucleotide polymorphisms (SNPs) rs1535 and rs174448 in the fatty acid desaturase (FADS) gene cluster have opposite effects on erythrocyte LCPUFAs at 9 mo.Objective: To explore whether SNPs in FADS and elongase (ELOVL) genes were associated with school performance in a sex-specific manner, we performed a Mendelian randomization study using data from the Optimal well-being, development and health for Danish children through a healthy New Nordic Diet (OPUS) School Meal Study with 765 Danish schoolchildren 8-11 y old...
May 17, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28510033/the-antagonistic-effect-of-selenium-on-cadmium-induced-damage-and-mrna-levels-of-selenoprotein-genes-and-inflammatory-factors-in-chicken-kidney-tissue
#4
Xinyue Wang, Rongkun Bao, Jing Fu
Selenium (Se) is a necessary trace mineral in the diet of humans and animals. Cadmium (Cd) is a toxic heavy metal that can damage animal organs, especially the kidneys. Antagonistic interactions between Se and Cd have been reported in previous studies. However, little is known about the effects of Se against Cd toxicity and on the mRNA levels of 25 selenoprotein genes and inflammatory factors in chicken kidneys. In the current study, we fed chickens with a Se-treated, Cd-treated, or Se/Cd treated diet for 90 days...
May 16, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28508477/the-novel-intracellular-protein-creg-inhibits-hepatic-steatosis-obesity-and-insulin-resistance
#5
Quan-Yu Zhang, Ling-Ping Zhao, Xiao-Xiang Tian, Cheng-Hui Yan, Yang Li, Yan-Xia Liu, Pi-Xiao Wang, Xiao-Jing Zhang, Ya-Ling Han
Cellular repressor of E1A-stimulated genes (CREG), a novel cellular glycoprotein, has been identified as a suppressor of various cardiovascular diseases (CVDs) because of its capacity to reduce hyperplasia, maintain vascular homeostasis, and promote endothelial restoration. However, the effects and mechanism of CREG in metabolic disorder and hepatic steatosis remain unknown. Here, we report that hepatocyte-specific CREG deletion dramatically exacerbates high fat diet (HFD) and leptin deficiency-induced (ob/ob) adverse effects such as obesity, hepatic steatosis and metabolic disorders, whereas a beneficial effect is conferred by CREG overexpression...
May 15, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28503189/eicosapentaenoic-acid-shows-anti-inflammatory-effect-via-gpr120-in-3t3-l1-adipocytes-and-attenuates-adipose-tissue-inflammation-in-diet-induced-obese-mice
#6
Hodaka Yamada, Tomio Umemoto, Masafumi Kakei, Shin-Ichi Momomura, Masanobu Kawakami, San-E Ishikawa, Kazuo Hara
BACKGROUND: Saturated fatty acids have been shown to cause insulin resistance and low-grade chronic inflammation, whereas unsaturated fatty acids suppress inflammation via G-protein coupled receptor 120 (GPR120) in macrophages. However, the anti-inflammatory effects of unsaturated fatty acids in adipocytes have yet to be elucidated. Hence, the aims of the present study were to evaluate the anti-inflammatory effects of eicosapentaenoic acid (EPA) via GPR120 in adipocytes. METHODS: We used 250 μM palmitate as a representative saturated fatty acid...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28501566/dna-methylation-regulated-gene-expression-in-organ-fibrosis
#7
REVIEW
Xiangyu Zhang, Min Hu, Xing Lyu, Chun Li, Victor J Thannickal, Yan Y Sanders
DNA methylation is a major epigenetic mechanism to regulate gene expression. Epigenetic regulation, including DNA methylation, histone modifications and RNA interference, results in heritable changes in gene expression independent of alterations in DNA sequence. Epigenetic regulation often occurs in response to aging and environment stimuli, including exposures and diet. Studies have shown that DNA methylation is critical in the pathogenesis of fibrosis involving multiple organs sytems, contributing to significant morbidity and mortality...
May 10, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28500613/functional-diets-modulate-lncrna-coding-rnas-and-gene-interactions-in-the-intestine-of-rainbow-trout-oncorhynchus-mykiss
#8
Gustavo Núñez-Acuña, Camille Détrée, Cristian Gallardo-Escárate, Ana Teresa Gonçalves
The advent of functional genomics has sparked the interest in inferring the function of non-coding regions from the transcriptome in non-model species. However, numerous biological processes remain understudied from this perspective, including intestinal immunity in farmed fish. The aim of this study was to infer long non-coding RNA (lncRNAs) expression profiles in rainbow trout (Oncorhynchus mykiss) fed for 30 days with functional diets based on pre- and probiotics. For this, whole transcriptome sequencing was conducted through Illumina technology, and lncRNAs were mined to evaluate transcriptional activity in conjunction with known protein sequences...
May 12, 2017: Marine Biotechnology
https://www.readbyqxmd.com/read/28496206/wisp1-ccn4-inhibits-adipocyte-differentiation-through-repression-of-ppar%C3%AE-activity
#9
Nathalie Ferrand, Véronique Béreziat, Marthe Moldes, Maurice Zaoui, Annette K Larsen, Michèle Sabbah
WISP1 (Wnt1-inducible signaling pathway protein-1, also known as CCN4) is a member of the CCN family able to mediate cell growth, transformation and survival in a tissue-specific manner. Here, we report that WISP1 expression was highly increased in preadipocytes and decreased during adipocyte differentiation. Moreover, we observed an increase in WISP1 gene expression in adipose tissue from both diet-induced and leptin-deficient ob/ob obese mice, suggesting that WISP1 could be involved in the pathophysiological onset of obesity...
May 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28496128/a-systems-genetics-approach-identified-gpd1l-and-its-molecular-mechanism-for-obesity-in-human-adipose-tissue
#10
Hao He, Dianjianyi Sun, Yong Zeng, Ruifeng Wang, Wei Zhu, Shaolong Cao, George A Bray, Wei Chen, Hui Shen, Frank M Sacks, Lu Qi, Hong-Wen Deng
To explore novel molecular mechanisms underlying obesity, we applied a systems genetics framework to integrate risk genetic loci from the largest body mass index (BMI) genome-wide association studies (GWAS) meta-analysis with mRNA and microRNA profiling in adipose tissue from 200 subjects. One module was identified to be most significantly associated with obesity and other metabolic traits. We identified eight hub genes which likely play important roles in obesity metabolism and identified microRNAs that significantly negatively correlated with hub genes...
May 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28494548/-the-role-of-cytochrome-p450-in-nonalcoholic-fatty-liver-induced-by-high-fat-diet-a-gene-expression-profile-analysis
#11
Y Liu, F Cheng, Y X Luo, P Hu, H Ren, M L Peng
Objective: To clarify the role of cytochrome P450 in nonalcoholic fatty liver disease (NAFLD) by RNA-Seq and bioinformatics analysis. Methods: A total of 20 male C57BL/6 mice were used. Ten mice were fed with high-fat diet (D12492, 60% kcal fat) for 16 weeks to establish a mouse model of NAFLD, and the other 10 mice were fed with low-fat diet (D12450B, 10% kcal fat) as control group. At the end of the experiment, the body weight, liver weight, and hepatic triglyceride (TG) content were measured. Meanwhile, HE staining and RNA-Seq analysis were performed for the liver tissues...
April 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/28487438/the-niemann-pick-c1-gene-interacts-with-a-high-fat-diet-to-promote-weight-gain-through-differential-regulation-of-central-energy-metabolism-pathways
#12
Joseph J Castillo, David Jelinek, Hao Wei, Nicholas P Gannon, Roger A Vaughan, L John Horwood, F John Meaney, Randi Garcia-Smith, Kristina A Trujillo, Randall A Heidenreich, David Meyre, Robert A Orlando, Renee C LeBoeuf, William S Garver
A genome-wide association study (GWAS) reported that common variation in the human Niemann-Pick C1 gene (NPC1) is associated with morbid adult obesity. This study was confirmed using our BALB/cJ Npc1 mouse model, whereby heterozygous mice (Npc1(+/-)) with decreased gene dosage were susceptible to weight gain when fed a high-fat diet (HFD) compared to homozygous normal mice (Npc1(+/+)) fed the same diet. The objective for our current study was to validate this Npc1 gene-diet interaction using statistical modeling with fitted growth trajectories, conduct body weight analyses for different measures, and define the physiological basis responsible for weight gain...
May 9, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28487392/epha2-expression-regulates-inflammation-and-fibroproliferative-remodeling-in-atherosclerosis
#13
Alexandra C Finney, Steven D Funk, Jonette Green, Arif Yurdagul, Mohammad A Rana, Rebecca Pistorius, Miriam Henry, Andrew D Yurochko, Christopher B Pattillo, James G Traylor, Jin Chen, Matthew D Woolard, Christopher G Kevil, A Wayne Orr
Background -Atherosclerotic plaque formation results from chronic inflammation and fibroproliferative remodeling in the vascular wall. We previously demonstrated that both human and mouse atherosclerotic plaques show elevated expression of EphA2, a guidance molecule involved in cell-cell interactions and tumorigenesis. Methods -Here, we assessed EphA2's role in atherosclerosis by deleting EphA2 in a mouse model of atherosclerosis (Apoe(-/-)) and by assessing EphA2 function in multiple vascular cell culture models...
May 9, 2017: Circulation
https://www.readbyqxmd.com/read/28486942/habitual-coffee-consumption-and-genetic-predisposition-to-obesity-gene-diet-interaction-analyses-in-three-us-prospective-studies
#14
Tiange Wang, Tao Huang, Jae H Kang, Yan Zheng, Majken K Jensen, Janey L Wiggs, Louis R Pasquale, Charles S Fuchs, Hannia Campos, Eric B Rimm, Walter C Willett, Frank B Hu, Lu Qi
BACKGROUND: Whether habitual coffee consumption interacts with the genetic predisposition to obesity in relation to body mass index (BMI) and obesity is unknown. METHODS: We analyzed the interactions between genetic predisposition and habitual coffee consumption in relation to BMI and obesity risk in 5116 men from the Health Professionals Follow-up Study (HPFS), in 9841 women from the Nurses' Health Study (NHS), and in 5648 women from the Women's Health Initiative (WHI)...
May 9, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28481225/impact-of-environmental-factors-on-alloimmunity-and-transplant-fate
#15
Leonardo V Riella, Jessamyn Bagley, John Iacomini, Maria-Luisa Alegre
Although gene-environment interactions have been investigated for many years to understand people's susceptibility to autoimmune diseases or cancer, a role for environmental factors in modulating alloimmune responses and transplant outcomes is only now beginning to emerge. New data suggest that diet, hyperlipidemia, pollutants, commensal microbes, and pathogenic infections can all affect T cell activation, differentiation, and the kinetics of graft rejection. These observations reveal opportunities for novel therapeutic interventions to improve graft outcomes as well as for noninvasive biomarker discovery to predict or diagnose graft deterioration before it becomes irreversible...
May 8, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28480144/transcriptome-assembly-and-candidate-genes-involved-in-nutritional-programming-in-the-swordtail-fish-xiphophorus-multilineatus
#16
Yuan Lu, Charlotte M Klimovich, Kalen Z Robeson, William Boswell, Oscar Ríos-Cardenas, Ronald B Walter, Molly R Morris
BACKGROUND: Nutritional programming takes place in early development. Variation in the quality and/or quantity of nutrients in early development can influence long-term health and viability. However, little is known about the mechanisms of nutritional programming. The live-bearing fish Xiphophorus multilineatus has the potential to be a new model for understanding these mechanisms, given prior evidence of nutritional programming influencing behavior and juvenile growth rate. We tested the hypotheses that nutritional programming would influence behaviors involved in energy homeostasis as well gene expression in X...
2017: PeerJ
https://www.readbyqxmd.com/read/28472596/reciprocal-regulation-between-mir-148a-152-and-dna-methyltransferase-1-is-associated-with-hyperhomocysteinemia-accelerated-atherosclerosis
#17
Anning Yang, Yue Sun, Yuan Gao, Songhao Yang, Caiyan Mao, Ning Ding, Mei Deng, Yanhua Wang, Xiaoling Yang, Yuexia Jia, Huiping Zhang, Yideng Jiang
DNA methyltransferase 1 (DNMT1) and miRNAs are both important regulators of gene expression that have been implicated in the pathogenesis of atherosclerosis. This study was designed to elucidate the potential interaction between DNMT1 and miRNAs in the context of hyperhomocysteinemia (HHcy)-related atherosclerosis. In the aorta of ApoE(-/-) mice fed a high methionine diet, increased expression of miR-148a/152, with decreased DNMT1 mRNA and protein levels, was detected. Similar changes were observed in cultured foam cells stimulated with homocysteine...
May 4, 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28465440/high-density-lipoprotein-receptor-scarb1-is-required-for-carotenoid-coloration-in-birds
#18
Matthew B Toomey, Ricardo J Lopes, Pedro M Araújo, James D Johnson, Małgorzata A Gazda, Sandra Afonso, Paulo G Mota, Rebecca E Koch, Geoffrey E Hill, Joseph C Corbo, Miguel Carneiro
Yellow, orange, and red coloration is a fundamental aspect of avian diversity and serves as an important signal in mate choice and aggressive interactions. This coloration is often produced through the deposition of diet-derived carotenoid pigments, yet the mechanisms of carotenoid uptake and transport are not well-understood. The white recessive breed of the common canary (Serinus canaria), which carries an autosomal recessive mutation that renders its plumage pure white, provides a unique opportunity to investigate mechanisms of carotenoid coloration...
May 2, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28464483/occurrence-of-antibiotic-resistance-genes-in-the-faecal-dna-of-healthy-omnivores-ovo-lacto-vegetarians-and-vegans
#19
Vesna Milanović, Andrea Osimani, Lucia Aquilanti, Stefano Tavoletti, Cristiana Garofalo, Serena Polverigiani, Alice Litta-Mulondo, Luca Cocolin, Ilario Ferrocino, Raffaella Di Cagno, Silvia Turroni, Camilla Lazzi, Nicoletta Pellegrini, Francesca Clementi
SCOPE: The effects of long-term omnivore, ovo-lacto vegetarian and vegan diets on the occurrence of 12 antibiotic resistance (AR) genes in the human gut was studied. METHODS AND RESULTS: The faeces of 144 healthy volunteers recruited from Turin, Bari, Bologna and Parma were screened for the occurrence of genes conferring resistance to tetracyclines, macrolide-lincosamide-streptogramin B, vancomycin and β-lactams. Overall, erm(B), tet(W) and tet(M) were detected at the highest frequency...
May 2, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28457653/study-of-the-relationship-between-apoa-ii%C3%A2-265t-c-polymorphism-and-hdl-function-in-response-to-weight-loss-in-overweight-and-obese-type-2-diabetic-patients
#20
Masoumeh Moradi, Maryam Mahmoudi, Ahmad Saedisomeolia, Mohammad Ali Mansournia, Roxana Zahirihashemi, Fariba Koohdani
BACKGROUND: It has been reported that people may respond differently to the same environmental changes because of genome variations. OBJECTIVE: The main purpose of the present study is to determine gene-diet interactions between -265T>C apolipoprotein A-II polymorphisms and evaluate the effect of weight loss on parameters related to HDL function. METHODS: In the present study, 56 overweight and obese type 2 diabetic patients were chosen from 697 genotype-specified subjects...
April 9, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
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