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https://www.readbyqxmd.com/read/28442806/study-of-clinical-profile-of-herpes-zoster-in-human-immunodeficiency-virus-positive-and-negative-patients-at-a-rural-based-tertiary-care-center-gujarat
#1
Rita V Vora, Gopikrishnan Anjaneyan, Rahul Krishna S Kota, Abhishek P Pilani, Nilofar G Diwan, Nidhi N Patel
BACKGROUND: Herpes zoster usually presents with typically grouped vesicles on erythematous base involving single dermatome with self-limiting nature in immunocompetent individuals while it may present in extensive form involving multiple dermatomes involvement or disseminated form in immunocompromised, especially in human immunodeficiency virus (HIV). AIMS AND OBJECTIVES: The aim of this study was to study the prevalence of HIV in patients of herpes zoster, to compare the clinical presentation of herpes zoster in HIV-infected and noninfected patient...
January 2017: Indian Journal of Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28436279/treatment-of-painful-radiculopathies-with-capsaicin-8-cutaneous-patch
#2
R Baron, R D Treede, F Birklein, T Cegla, R Freynhagen, M L Heskamp, K U Kern, C Maier, R Rolke, S Seddigh, C Sommer, S Ständer, C Maihöfner
BACKGROUND AND OBJECTIVE: The treatment of neuropathic pain due to low-back (lumbosacral) radiculopathies, a common source of neuropathic pain, is challenging and often requires a multimodal therapeutic approach. The capsaicin 8% patch is the first topical analgesic licensed for peripheral neuropathic pain. To evaluate this treatment, a subset of patients with painful radiculopathy (lumbar and cervical, including ventral and dorsal rami) enrolled into the multicenter, non-interventional QUEPP study (Qutenza™ - safety and effectiveness in peripheral neuropathic pain) was analyzed...
April 22, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28435923/bone-bridge-formation-across-the-neuroforamen-14-years-after-instrumented-fusion-for-isthmic-spondylolisthesis-a-case-report
#3
Joel Louis Lim, Kimberly-Anne Tan, Hwee Weng Dennis Hey
This case report describes the first case of a bone bridge formation across the left L5/S1 neuroforamen after instrumented posterolateral fusion for L5/S1 isthmic spondylolisthesis. Our patient was a 70-year-old lady who had grade 2, L5/S1 isthmic spondylolisthesis and bilateral S1 nerve root compression. She suffered from mechanical low back pain and neurogenic claudication, with radicular pain over both S1 dermatomes. She underwent in-situ, instrumented, posterolateral fusion and was asymptomatic for more than 13 years before developing progressive onset of left radicular pain over the L5 dermatome...
March 2017: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/28431427/total-spinal-anesthesia-failure-have-you-assessed-the-sensory-anesthesia-in-sacral-dermatomes
#4
Ronaldo Rodrigo de Sá Oliveira, Marília Pinheiro Módolo, Glênio Bitencourt Mizubuti, Anthony M H Ho, Guilherme Antonio Moreira de Barros, Leopoldo Muniz da Silva, Leandro Gobbo Braz, Norma Sueli Pinheiro Módolo, Andrew G Day, Rachel Phelan, Lais Helena Navarro E Lima, Eliana Marisa Ganem
Intrathecal local anesthetic maldistribution is a well-known cause of spinal anesthesia failure (SAF). This could potentially result in sensory blockade restricted to the sacral dermatomes. We sought to determine the overall incidence of SAF and the role of sacral dermatomes in differentiating between total and partial failures. Of the 3111 spinals prospectively examined, 194 (6.2%) were classified as failures. Of the 72 presumed total failures based on the initial assessment, evaluation of the sacral dermatomes revealed sensory blockade in 32 (44%; 95% confidence interval, 32...
May 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28427688/pruritus-may-be-a-common-symptom-related-to-neuromyelitis-optica-spectrum-disorders
#5
Zhiyong He, Ming Ren, Xiaofeng Wang, Qifeng Guo, Xiaokun Qi
BACKGROUND: To evaluate pruritus in patients with neuromyelitis optica spectrum disorders (NMOSD) and to characterize the relationship between pruritus and lesions of NMOSD. METHODS: 61 patients with NMOSD were included in the study and their medical records were reviewed for pruritus, neurological symptoms and magnetic resonance imaging (MRI) images. We focused on the patients' history of pruritus, especially the severity, duration, region, and the relationship of pruritus with other symptoms of NMOSD...
April 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28416562/henry-head-herpes-zoster-and-the-graphic-development-of-his-scheme-of-the-dermatomes-in-man
#6
G D Schott
No abstract text is available yet for this article.
April 17, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28413738/high-energy-trauma-precipitating-intramedullary-cavernous-malformation-hemorrhage-a-possible-underreported-mechanism
#7
Pedro Aguilar-Salinas, Douglas Gonsales, Leonardo B Brasiliense, Eric Sauvageau, Ricardo A Hanel
Cavernous malformations are uncommon vascular lesions with an estimated prevalence of 0.5% in the general population. Intramedullary cavernous malformations (ICM) represent a rare subset of lesions, which account for approximately 5% of all cavernous malformations. The annual risk of hemorrhage in ICMs has been reported to range from 1.4 to 6.8%. Most patients are diagnosed with neurological dysfunction secondary to ICM hemorrhage and little is known about the inciting events that lead to hemorrhage. A few studies have suggested that minor and major trauma or even intense exertion may increase the risk of hemorrhage...
March 13, 2017: Curēus
https://www.readbyqxmd.com/read/28413557/c2-primary-leiomyoma-in-an-immunocompetent-woman-a-case-report-and-review-of-literature
#8
Mohana Rao Patibandla, Madhukar T Nayak, A K Purohit, Megha Uppin, Sundaram Challa, Gokul Chowdary Addagada, Manisha Nukavarapu
Clinical case report and review of the literature. This is the first case of primary leiomyoma in an immunocompetent woman without previous history of uterine leiomyoma being reported in the literature to the best of our knowledge. Leiomyoma, a type of smooth muscle cell tumor, involving the vertebra is extremely rare. There were very few primary leiomyoma in patients with AIDS or in the immune-suppressed patients. This 48-year-old female came with H/o neck pain, weakness and bladder retention. On examination, tone increased in all four limbs, power on the right side of the limbs 4/5, power on the left upper limb 0/5, lower limb 3/5, left plantar was up going, decreased sensation over the left second cervical vertebra (C2) dermatome and all modalities decreased below C2...
January 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28410481/leg-symptoms-associated-with-sacroiliac-joint-disorder-and-related-pain
#9
Eiichi Murakami, Toshimi Aizawa, Daisuke Kurosawa, Kyoko Noguchi
OBJECTIVE: The symptoms of sacroiliac joint (SIJ) disorders are usually detected in the buttock and groin, and occasionally referred to the thigh and leg. However, lumbar disorders also cause symptoms in these same body regions. The presence of a characteristic, symptomatic pattern in the legs would be useful for diagnosing SIJ disorders. This study aimed to identify specific leg symptoms in patients with SIJ pain originating from the posterior sacroiliac ligament and determine the rate of occurrence of these symptoms...
March 30, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28386739/analgesia-and-side-effects-of-the-addition-of-10-or-20%C3%A2-%C3%A2%C2%B5g-fentanyl-to-articaine-in-spinal-anesthesia-for-knee-arthroscopy-a-randomized-and-observer-blinded-study
#10
Paula Stenman, Merja Salonen, Pekka Tarkkila, Per Rosenberg
OBJECTIVES: Articaine, a popular and rapidly acting local anesthetic in dentistry, has been also found to be beneficial in ambulatory spinal anesthesia. Analgesia in the intraoperative and immediate postoperative period may be further improved by adding fentanyl to the local anesthetic solution for spinal anesthesia. The aim was to evaluate dose-dependency of analgesia and side effects associated with intrathecal fentanyl additive to articaine for spinal anesthesia in knee arthroscopy patients...
April 6, 2017: Journal of Anesthesia
https://www.readbyqxmd.com/read/28365432/long-term-outcome-of-brachial-plexus-re-implantation-after-complete-brachial-plexus-avulsion-injury
#11
C Kachramanoglou, T Carlstedt, M Koltzenburg, D Choi
BACKGROUND: Complete brachial plexus avulsion injury is a severe disabling injury due to traction to the brachial plexus. Brachial plexus re-implantation is an emerging surgical technique for the management of complete brachial plexus avulsion injury. OBJECTIVE: We assessed the functional recovery in 15 patients who have undergone brachial plexus re-implantation surgery after complete brachial plexus avulsion injury with clinical examination and electrophysiological testing METHODS: We included all patients that underwent brachial plexus re-implantation in our institution between 1997 and 2010...
March 29, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28357109/atypical-breast-adenosquamous-carcinoma-following-acute-myeloid-leukemia-in-a-middle-aged-woman-a-case-report
#12
Seyed Mehdi Hashemi, Shokoufeh Mahmoudi Shan, Mahdi Jahantigh, Abolghasem Allahyari
Adenosquamous carcinoma of the breast is a rare cancer that develops as glands and tubules admixed with solid nests of squamous cells in a spindle cell background. Furthermore, its occurrence following AML is also rare. To the best of our knowledge, based on a review of the relevant literature, thus far there have not been any welldocumented cases. In the present case report, we report on a middle-aged woman with a 2year history of acute myeloid leukemia (AML) who was admitted to hospital due to a mass in the right breast, with concurrent cutaneous lesions on the breast...
February 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28343991/ftransdermal-iontophoretic-delivery-of-lysine-proline-valine-kpv-peptide-across-microporated-human-skin
#13
Kasturi Pawar, Chandra S Kolli, Vijaya K Rangari, R Jayachandra Babu
Lysine-Proline-Valine (KPV) is a C-terminal peptide fragment of α-MSH with potent anti-inflammatory properties. Current study investigates various transdermal enhancement strategies such as iontophoresis (ITP), microneedles (MN) and their combination (ITP+MN) on KPV delivery across dermatomed human skin. KPV attains a positive charge at pH below 7.0, thus anodal ITP was employed. The influence of current strength, KPV concentration, and duration of current application on the KPV delivery was investigated. At defined ITP parameters, the influence of MN on KPV delivery (ITP+MN) across skin was also determined...
March 23, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28337957/transplantation-of-cultured-olfactory-bulb-cells-prevents-abnormal-sensory-responses-during-recovery-from-dorsal-root-avulsion-in-the-rat
#14
Andrew Collins, Daqing Li, Stephen B McMahon, Geoffrey Raisman, Ying Li
The central branches of the C7 and C8 dorsal roots were avulsed close to their entry point into the spinal cord in adult rats. The forepaw responses to heat and cold stimuli were tested at 1, 2 and 3 weeks after injury. Over this period the paws were sensitive to both stimuli at 1-2 weeks and returned towards normal at 3 weeks. Immunohistology showed no evidence of axonal regeneration into the spinal cord in a control group of rats with avulsion only, implying that adjacent dorsal roots and their corresponding dermatomes were involved in the recovery...
March 23, 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28337820/selective-radiofrequency-stimulation-of-the-dorsal-root-ganglion-drg-as-a-method-for-predicting-targets-for-neuromodulation-in-patients-with-post-amputation-pain-a-case-series
#15
Corey W Hunter, Ajax Yang, Tim Davis
OBJECTIVE: While spinal cord stimulation (SCS) has established itself as an accepted and validated treatment for neuropathic pain, there are a number of conditions where it has experienced less, long-term success: post amputee pain (PAP) being one of them. Dorsal root ganglion (DRG) stimulation has shown great promise, particularly in conditions where traditional SCS has fallen short. One major difference between DRG stimulation and traditional SCS is the ability to provide focal stimulation over targeted areas...
March 23, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28321983/chloroprocaine-for-epidural-anesthesia-in-infants-and-children
#16
REVIEW
Giorgio Veneziano, Joseph D Tobias
Continuous epidural infusions are an effective and safe method of providing anesthesia and postoperative analgesia in infants and children with multiple advantages over systemic medications, including earlier tracheal extubation, decreased perioperative stress response, earlier return of bowel function, and decreased exposure to volatile anesthetic agents with uncertain long-term neurocognitive effects. Despite these benefits, local anesthetic toxicity remains a concern in neonates and infants because of their decreased metabolic capacity for amide local anesthetics...
March 21, 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/28321676/transdermal-delivery-of-human-growth-hormone-via-laser-generated-micropores
#17
Yang Song, Karishma Hemmady, Ashana Puri, Ajay K Banga
The epidermal skin barrier plays an important role in protecting underlying structures. It allows the passage of low molecular weight lipophilic molecules, but restricts the passage of hydrophilic molecules and macromolecules. The objective of this study was to investigate the feasibility of transdermal delivery of human growth hormone (hGH) through laser-microporated dermatomed porcine ear skin. The permeation of hGH was evaluated at different laser fluences and micropore densities. In vitro permeation studies were performed on vertical Franz diffusion cells using dermatomed porcine ear skin treated with ablative laser (2940 nm; P...
March 20, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28319552/evaluation-of-lung-function-and-clinical-features-of-the-ultrasound-guided-stellate-ganglion-block-with-2-different-concentrations-of-a-local-anesthetic-a-randomized-controlled-trial
#18
Won-Joong Kim, Hahck Soo Park, Myung Sub Yi, Gill-Hoi Koo, Hwa-Yong Shin
BACKGROUND: One possible complication of stellate ganglion block (SGB) is respiratory compromise. No study has yet addressed the comparison of its effect on lung function and clinical features, including Horner's syndrome, changes in temperature, sensory and motor functions, and adverse events of lower versus higher concentrations (LC and HC, respectively) of local anesthetics in an ultrasound-guided SGB. METHODS: Fifty patients were randomized into 1 of 2 groups: the LC group (5 mL of 0...
April 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28317524/segmental-vitiligo
#19
REVIEW
Nanja van Geel, Reinhart Speeckaert
Segmental vitiligo is characterized by its early onset, rapid stabilization, and unilateral distribution. Recent evidence suggests that segmental and nonsegmental vitiligo could represent variants of the same disease spectrum. Observational studies with respect to its distribution pattern point to a possible role of cutaneous mosaicism, whereas the original stated dermatomal distribution seems to be a misnomer. Although the exact pathogenic mechanism behind the melanocyte destruction is still unknown, increasing evidence has been published on the autoimmune/inflammatory theory of segmental vitiligo...
April 2017: Dermatologic Clinics
https://www.readbyqxmd.com/read/28315385/a-study-on-the-in-vitro-percutaneous-absorption-of-silver-nanoparticles-in-combination-with-aluminum-chloride-methyl-paraben-or-di-n-butyl-phthalate
#20
Katarzyna Domeradzka-Gajda, Marek Nocuń, Joanna Roszak, Beata Janasik, C Derrick Quarles, Wojciech Wąsowicz, Jarosław Grobelny, Emilia Tomaszewska, Grzegorz Celichowski, Katarzyna Ranoszek-Soliwoda, Małgorzata Cieślak, Dorota Puchowicz, Jhanis J Gonzalez, Richard E Russo, Maciej Stępnik
Some reports indicate that the silver released from dermally applied products containing silver nanoparticles (AgNP) (e.g. wound dressings or cosmetics) can penetrate the skin, particularly if damaged. AgNP were also shown to have cytotoxic and genotoxic activity. In the present study percutaneous absorption of AgNP of two different nominal sizes (Ag15nm or Ag45nm by STEM) and surface modification, i.e. citrate or PEG stabilized nanoparticles, in combination with cosmetic ingredients, i.e. aluminum chloride (AlCl3), methyl paraben (MPB), or di-n-butyl phthalate (DBPH) was assessed using in vitro model based on dermatomed pig skin...
March 14, 2017: Toxicology Letters
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