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https://www.readbyqxmd.com/read/27911127/immediate-and-lasting-effects-of-a-thoracic-spine-manipulation-in-a-patient-with-signs-of-cervical-radiculopathy-and-upper-extremity-hyperalgesia-a-case-report
#1
Beth K Deschenes, Jason Zafereo
Patients with cervical radiculopathy (CR) may present with accompanying symptoms of hyperalgesia, allodynia, heaviness in the arm, and non-segmental pain that do not appear to be related to a peripheral spinal nerve. These findings may suggest the presence of central or autonomic nervous system involvement, requiring a modified management approach. The purpose of this case report is to describe the treatment of a patient with signs of CR and upper extremity (UE) hyperalgesia who had a significant decrease in her UE pain and hypersensitivity after a single thoracic spine manipulation (TSM)...
December 2, 2016: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/27906061/laminin-and-matrix-metalloproteinase-11-regulate-fibronectin-levels-in-the-zebrafish-myotendinous-junction
#2
Molly H Jenkins, Sarah S Alrowaished, Michelle F Goody, Bryan D Crawford, Clarissa A Henry
BACKGROUND: Remodeling of the extracellular matrix (ECM) regulates cell adhesion as well as signaling between cells and their microenvironment. Despite the importance of tightly regulated ECM remodeling for normal muscle development and function, mechanisms underlying ECM remodeling in vivo remain elusive. One excellent paradigm in which to study ECM remodeling in vivo is morphogenesis of the myotendinous junction (MTJ) during zebrafish skeletal muscle development. During MTJ development, there are dramatic shifts in the primary components comprising the MTJ matrix...
May 2, 2016: Skeletal Muscle
https://www.readbyqxmd.com/read/27861224/neuralgic-amyotrophy-associated-with-hepatitis-e-virus-infection-first-case-in-the-united-states
#3
Jose D Avila, David Lacomis, Erek M Lam
Hepatitis E is an emerging viral infection in developed countries. It can present with multiple extra-hepatic manifestations, including neuralgic amyotrophy. We report a 52-year-old man who presented with neck and shoulder pain followed by orthopnea and left arm weakness. Electrodiagnostic testing showed left phrenic neuropathy and denervation in bilateral C5 and C6 myotomes. He also had elevated liver enzymes, which led to the diagnosis of acute hepatitis E. This is the first case of neuralgic amyotrophy associated with hepatitis E in the United States...
December 2016: Journal of Clinical Neuromuscular Disease
https://www.readbyqxmd.com/read/27834030/does-the-grass-snake-natrix-natrix-squamata-serpentes-natricinae-fit-the-amniotes-specific-model-of-myogenesis
#4
Damian Lewandowski, Magda Dubińska-Magiera, Ewelina Posyniak, Weronika Rupik, Małgorzata Daczewska
In the grass snake (Natrix natrix), the newly developed somites form vesicles that are located on both sides of the neural tube. The walls of the vesicles are composed of tightly connected epithelial cells surrounding the cavity (the somitocoel). Also, in the newly formed somites, the Pax3 protein can be observed in the somite wall cells. Subsequently, the somite splits into three compartments: the sclerotome, dermomyotome (with the dorsomedial [DM] and the ventrolateral [VL] lips) and the myotome. At this stage, the Pax3 protein is detected in both the DM and VL lips of the dermomyotome and in the mononucleated cells of the myotome, whereas the Pax7 protein is observed in the medial part of the dermomyotome and in some of the mononucleated cells of the myotome...
November 10, 2016: Protoplasma
https://www.readbyqxmd.com/read/27822248/proteomic-analysis-of-muscle-tissue-from-rainbow-trout-oncorhynchus-mykiss-fed-dietary-%C3%AE-glucan
#5
Gh Ghaedi, S Keyvanshokooh, H Mohammadi Azarm, M Akhlaghi
The aim of this study was to examine the changes in muscle proteome of the rainbow trout fed dietary β-glucan. The experimental diets contained 0 (control), 0.1% and 0.2% β-1,3/1,6 yeast glucan. First, feeding larvae were fed to apparent satiation nine times per day with their respective diets over two months. The percentage of body weight gain and feed efficiency of fish fed 0.2% diet was significantly higher than those of fish fed the control and 0.1% diets. Fish fed the control and 0.2% diets were subjected to proteomic analysis...
2016: Iranian journal of veterinary research
https://www.readbyqxmd.com/read/27756225/gene-expression-profiling-of-trout-regenerating-muscle-reveals-common-transcriptional-signatures-with-hyperplastic-growth-zones-of-the-post-embryonic-myotome
#6
Jerôme Montfort, Aurelie Le Cam, Jean-Charles Gabillard, Pierre-Yves Rescan
BACKGROUND: Muscle fibre hyperplasia stops in most fish when they reach approximately 50 % of their maximum body length. However, new small-diameter muscle fibres can be produced de novo in aged fish after muscle injury. Given that virtually nothing is known regarding the transcriptional mechanisms that regulate regenerative myogenesis in adult fish, we explored the temporal changes in gene expression during trout muscle regeneration following mechanical crushing. Then, we compared the gene transcription profiles of regenerating muscle with the previously reported gene expression signature associated with muscle fibre hyperplasia...
October 18, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27709072/hirayama-s-disease-an-italian-single-center-experience-and-review-of-the-literature
#7
Valerio Vitale, Ferdinando Caranci, Chiara Pisciotta, Fiore Manganelli, Francesco Briganti, Lucio Santoro, Arturo Brunetti
BACKGROUND: Hirayama's disease (HD), is a benign, self-limited, motor neuron disease, characterized by asymmetric weakness and atrophy of one or both distal upper extremities. In the present study we report the clinical, electrophysiological and MRI features of a group of Italian patients, with review of the literature. Moreover we propose an optimized MRI protocol for patients with suspected or diagnosed HD in order to make an early diagnosis and a standardized follow up. METHODS: Eight patients with clinical suspicion of Hirayama disease underwent evaluation between January 2007 and November 2013...
August 2016: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/27632017/generation-of-a-mef2aa-egfp-transgenic-zebrafish-line-that-expresses-egfp-in-muscle-cells
#8
Feng Lv, Chenwen Zhu, Xinghong Yan, Xin Wang, Dong Liu
Transgenesis is an important tool for exploring gene expression and function. The myocyte enhancer factor 2a (mef2a) gene encodes a member of the Mef2 protein family that is involved in vertebrate skeletal, cardiac, and smooth muscle development and differentiation during myogenesis. According to studies on human and animal models, mef2a is highly expressed in the heart and somites. To explore the potential of mef2a as a tool for selective labeling of muscle cells in living zebrafish embryos, we constructed a transgene mef2aa:EGFP to induce the expression of green fluorescent protein (GFP) under the control of mef2a promoter...
September 8, 2016: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/27580767/a-resegmentation-shift-model-for-vertebral-patterning
#9
Lizzy Ward, Susan E Evans, Claudio D Stern
Segmentation of the vertebrate body axis is established in the embryo by formation of somites, which give rise to the axial muscles (myotome) and vertebrae (sclerotome). To allow a muscle to attach to two successive vertebrae, the myotome and sclerotome must be repositioned by half a segment with respect to each other. Two main models have been put forward: 'resegmentation' proposes that each half-sclerotome joins with the half-sclerotome from the next adjacent somite to form a vertebra containing cells from two successive somites on each side of the midline...
September 1, 2016: Journal of Anatomy
https://www.readbyqxmd.com/read/27571325/development-of-the-epaxial-muscles-in-the-human-embryo
#10
Hayelom K Mekonen, Jill P J M Hikspoors, Greet Mommen, S Eleonore Köhler, Wouter H Lamers
Although the intrinsic muscles of the back are defined by their embryological origin and innervation pattern, no detailed study on their development is available. Human embryos (5-10 weeks development) were studied, using Amira3D® reconstruction and Cinema4D® remodelling software for visualization. At Carnegie Stage (CS)15, the epaxial portions of the myotomes became identifiable laterally to the developing vertebrae. At CS16, these portions fused starting cranially to form a longitudinal muscle column, which became innervated by the dorsal branches of the spinal nerves...
August 29, 2016: Clinical Anatomy
https://www.readbyqxmd.com/read/27531414/microxrf-tomographic-visualization-of-zinc-and-iron-in-the-zebrafish-embryo-at-the-onset-of-the-hatching-period
#11
Daisy Bourassa, Sophie-Charlotte Gleber, Stefan Vogt, Chong Hyun Shin, Christoph J Fahrni
Transition metals such as zinc, copper, and iron play key roles in cellular proliferation, cell differentiation, growth, and development. Over the past decade, advances in synchrotron X-ray fluorescence instrumentation presented new opportunities for the three-dimensional mapping of trace metal distributions within intact specimens. Taking advantage of microXRF tomography, we visualized the 3D distribution of zinc and iron in a zebrafish embryo at the onset of the hatching period. The reconstructed volumetric data revealed distinct differences in the elemental distributions, with zinc predominantly localized to the yolk and yolk extension, and iron to various regions of the brain as well as the myotome extending along the dorsal side of the embryo...
October 1, 2016: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/27468275/distinguishing-radiculopathies-from-mononeuropathies
#12
Jennifer Robblee, Hans Katzberg
Identifying "where is the lesion" is particularly important in the approach to the patient with focal dysfunction where a peripheral localization is suspected. This article outlines a methodical approach to the neuromuscular patient in distinguishing focal neuropathies versus radiculopathies, both of which are common presentations to the neurology clinic. This approach begins with evaluation of the sensory examination to determine whether there are irritative or negative sensory signs in a peripheral nerve or dermatomal distribution...
2016: Frontiers in Neurology
https://www.readbyqxmd.com/read/27463683/transcriptome-analysis-and-postprandial-expression-of-amino-acid-transporter-genes-in-the-fast-muscles-and-gut-of-chinese-perch-siniperca-chuatsi
#13
Ping Wu, Yulong Li, Jia Cheng, Lin Chen, Ming Zeng, Yuanan Wu, Jianhua Wang, Jianshe Zhang, Wuying Chu
The characterization of the expression and regulation of growth-related genes in the muscles of Chinese perch is of great interest to aquaculturists because of the commercial value of the species. The transcriptome annotation of the skeletal muscles is a crucial step in muscle growth-related gene analysis. In this study, we generated 52 504 230 reads of mRNA sequence data from the fast muscles of the Chinese perch by using Solexa/Illumina RNA-seq. Twenty-one amino acid transporter genes were annotated by searching protein and gene ontology databases, and postprandial changes in their transcript abundance were assayed after administering a single satiating meal to Chinese perch juveniles (body mass, approximately 100 g), following fasting for 1 week...
2016: PloS One
https://www.readbyqxmd.com/read/27430450/imaging-of-progressive-weakness-or-numbness-of-central-or-peripheral-origin
#14
Joshua P Klein
Weakness and numbness occur in a variety of patterns that reflect injury to different parts of the central and peripheral nervous system. Progressive symptoms most often signify an underlying structural or degenerative problem. Familiarity with the major descending motor and ascending sensory tracts of the central nervous system, as well as radicular (dermatome and myotome) and peripheral nerve anatomy, is essential. Damage to these tracts and nerve fibers produces characteristic clinical symptoms and signs...
2016: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/27380812/developmental-dynamics-of-occipital-and-cervical-somites
#15
Anja Maschner, Stefanie Krück, Margarethe Draga, Felicitas Pröls, Martin Scaal
Development of somites leading to somite compartments, sclerotome, dermomyotome and myotome, has been intensely investigated. Most knowledge on somite development, including the commonly used somite maturation stages, is based on data from somites at thoracic and lumbar levels. Potential regional differences in somite maturation dynamics have been indicated by a number of studies, but have not yet been comprehensively examined. Here, we present an overview on the developmental dynamics of somites at occipital and cervical levels in the chicken embryo...
July 6, 2016: Journal of Anatomy
https://www.readbyqxmd.com/read/27301061/international-standards-for-neurological-classification-of-spinal-cord-injury-impact-of-the-revised-worksheet-revision-02-13-on-classification-performance
#16
Christian Schuld, Steffen Franz, Karin Brüggemann, Laura Heutehaus, Norbert Weidner, Steven C Kirshblum, Rüdiger Rupp
STUDY DESIGN: Prospective cohort study. OBJECTIVES: Comparison of the classification performance between the worksheet revisions of 2011 and 2013 of the International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI). SETTINGS: Ongoing ISNCSCI instructional courses of the European Multicenter Study on Human Spinal Cord Injury (EMSCI). For quality control all participants were requested to classify five ISNCSCI cases directly before (pre-test) and after (post-test) the workshop...
September 2016: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/27141287/laminin-and-matrix-metalloproteinase-11-regulate-fibronectin-levels-in-the-zebrafish-myotendinous-junction
#17
Molly H Jenkins, Sarah S Alrowaished, Michelle F Goody, Bryan D Crawford, Clarissa A Henry
BACKGROUND: Remodeling of the extracellular matrix (ECM) regulates cell adhesion as well as signaling between cells and their microenvironment. Despite the importance of tightly regulated ECM remodeling for normal muscle development and function, mechanisms underlying ECM remodeling in vivo remain elusive. One excellent paradigm in which to study ECM remodeling in vivo is morphogenesis of the myotendinous junction (MTJ) during zebrafish skeletal muscle development. During MTJ development, there are dramatic shifts in the primary components comprising the MTJ matrix...
2016: Skeletal Muscle
https://www.readbyqxmd.com/read/27103876/cobitis-takenoi-sp-n-cypriniformes-cobitidae-a-new-spined-loach-from-honshu-island-japan
#18
Jun Nakajima
A new species of spined loach, Cobitis takenoi sp. n., is described based on the holotype and ten paratypes collected from Tango District, Honshu Island, Japan. The new species is distinguished by a combination of the following character states: 1) the lamina circularis at the base of the pectoral fin in adult male having a simple roundish plate form; 2) a narrowing of the upper segments of the first branched ray of the pectoral fin; 3) a short maxillary barbel whose length equals diameter of the eye; 4) 14 prepelvic myotomes, and 5) L3 and L5 well developed, forming longitudinal obvious stripes in males during the spawning season...
2016: ZooKeys
https://www.readbyqxmd.com/read/27068707/secondary-hyperalgesia-occurs-regardless-of-unilateral-or-bilateral-knee-osteoarthritis-involvement-in-individuals-with-mild-or-moderate-level
#19
Vanessa Martins Pereira Silva Moreira, Saulo Delfino Barboza, Juliana Borges Oliveira, Janser Moura Pereira, Valdeci Carlos Dionisio
BACKGROUND: Secondary hyperalgesia in individuals with less severe levels of knee osteoarthritis remains unclear. The objective of this study was to measure the pressure pain threshold (PPT) of individuals with mild or moderate knee osteoarthritis (KOA) and compare with no osteoarthritis. METHODS: Ten healthy controls and 30 individuals with mild or moderate KOA divided into two groups (unilateral and bilateral involvement) were included. Dermatomes (L1, L2, L3, L4, L5, S1, and S2), myotomes (vastus medialis, vastus lateralis, rectus femoris, adductor longus, tibialis anterior, peroneus longus, iliacus, quadratus lumborum, and popliteus muscles), and sclerotomes (L1-L2, L2-L3, L3-L4, L4-L5 supraspinous ligaments), over the L5-S1 and S1-S2 sacral areas, pes anserinus bursae, and at the patellar tendon) PPT were assessed and compared between individuals with and without KOA...
March 24, 2016: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/27054454/diagnosis-and-treatment-of-c4-radiculopathy
#20
Donald A Ross, Miner N Ross
STUDY DESIGN: Clinical case series. OBJECTIVE: This study sought to clarify symptoms, diagnostic criteria, and treatment of C4 radiculopathy, and the role of diagnostic C4 root block in this entity. SUMMARY OF BACKGROUND DATA: Although well understood cervical dermatomal/myotomal syndromes have been described for symptoms originating from impingement on the C2, C3, C5, C6, C7, and C8 roots, less has been written about the syndrome(s) associated with the C4 root...
December 1, 2016: Spine
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