Anna Evans Phillips, Elham Afghani, Venkata Sandeep Akshintala, Panayiotis Y Benos, Rohit Das, Asbjørn Mohr Drewes, Jeffrey Easler, Mahya Faghih, Charles Gabbert, Vivek Halappa, Mouen A Khashab, Søren Schou Olesen, Jami L Saloman, Biatta Sholosh, Adam Slivka, Tianxiu Wang, Dhiraj Yadav, Vikesh K Singh
INTRODUCTION: Treatment for abdominal pain in patients with chronic pancreatitis (CP) remains challenging in the setting of central nervous system sensitisation, a phenomenon of remodelling and neuronal hyperexcitability resulting from persistent pain stimuli. This is suspected to render affected individuals less likely to respond to conventional therapies. Endotherapy or surgical decompression is offered to patients with pancreatic duct obstruction. However, the response to treatment is unpredictable...
March 21, 2024: BMJ Open