keyword
https://read.qxmd.com/read/38480165/revision-of-the-afrotropical-genus-zetheumenidion-bequaert-hymenoptera-vespidae-eumeninae
#21
JOURNAL ARTICLE
Marco Selis
A taxonomic revision of the Afrotropical genus Zetheumenidion Bequaert, 1926 is presented. Four new species (Zetheumenidion abruptum sp. nov., Zetheumenidion concinnoide sp. nov., Zetheumenidion latum sp. nov. and Zetheumenidion minimum sp. nov.) are described; Zetheumenidion paeneplanum (Bequaert, 1926) stat. rev. is resurrected from synonymy with Z. pulchripenne (Cameron, 1910); Zetheumenidion femoratum flavissimum Giordani Soika, 1987 is raised to species level (Zetheumenidion flavissimum stat. nov.). A key to all known species is provided and the taxonomic placement of the genus is discussed...
February 2, 2024: Zootaxa
https://read.qxmd.com/read/38480114/morphological-phylogeny-and-revision-of-sycophila-and-ficomila-hymenoptera-chalcidoidea-eurytomidae-associated-with-afrotropical-fig-trees-moraceae-ficus
#22
JOURNAL ARTICLE
Hossein Lotfalizadeh, Grard Delvare, Astrid Cruaud, Jean-Yves Rasplus
Eurytomidae (Chalcidoidea) species associated with fig trees (Ficus) are still poorly documented. A phylogenetic analysis of 63 morphological characters was conducted to revise Afrotropical species of Sycophila Walker and Ficomila Bouek associated with fig trees. Based on our results, which also included Palaearctic species of Sycophila, three subgenera of Sycophila are proposed: Sycophila s. str., Tineomyza Rondani stat. rev. and a new subgenus, Ficorytoma subgen. n. Lotfalizadeh & Rasplus. Ficomila is maintained as a valid genus...
January 17, 2024: Zootaxa
https://read.qxmd.com/read/38479724/rho-kinase-inhibitor-alleviates-cd4-t-cell-mediated-corneal-graft-rejection-by-modulating-its-stat3-and-stat5-activation
#23
JOURNAL ARTICLE
Shang Li, Peng Zhang, Ao Li, Jiayu Bao, Zhiqiang Pan, Ying Jie
Penetrating keratoplasty remains the most common treatment to restore vision for corneal diseases. Immune rejection after corneal transplantation is one of the major causes of graft failure. In recent years, Rho-associated protein kinase (ROCK) inhibitors have been found to be associated with the activation of the STATs pathway and are widely studied in autoimmune diseases. Therefore, it may be possible that the ROCK inhibitors also participate in the local and systemic immune regulation in corneal transplantation through activation of the STATs pathway and affect the CD4+ T cell differentiation...
March 11, 2024: Experimental Eye Research
https://read.qxmd.com/read/38479567/phb2-inhibits-wssv-replication-by-promoting-the-nuclear-translocation-of-stat
#24
JOURNAL ARTICLE
Si Jia-Yu, Wu Lian-Jie, Xu Feng-Lin, Cao Xiao-Tong, Jiang-Feng Lan
Prohibitins (PHBs) are ubiquitously expressed conserved proteins in eukaryotes that are associated with apoptosis, cancer formation, aging, stress responses and cell proliferation. However, the function of the PHBs in immune regulation has largely not been determined. In the present study, we identified PHB2 in the red swamp crayfish Procambarus clarkii. PHB2 was found to be widely distributed in several tissues, and its expression was significantly upregulated by white spot syndrome virus (WSSV) challenge...
March 11, 2024: Fish & Shellfish Immunology
https://read.qxmd.com/read/38479544/homotherapy-for-heteropathy-of-bupleurum-chinense-dc-scutellaria-baicalensis-georgi-in-treating-depression-and-colorectal-cancer-a-network-pharmacology-and-animal-model-approach
#25
JOURNAL ARTICLE
Ruolan Sun, Yan Liang, Shijiao Zhu, Qihang Yin, Yong Bian, Hongyue Ma, Fan Zhao, Gang Yin, Decai Tang
ETHNOPHARMACOLOGICAL RELEVANCE: Bupleurum chinense DC.-Scutellaria baicalensis Georgi (BS) is a classic drug pair that has good clinical effects on depression and many tumors. However, the concurrent targeting mechanism of how the aforementioned drug pair is valid in the two distinct diseases, has not been clarified yet. AIM OF THE STUDY: The components of BS were detected by LC-MS, combined with network pharmacology to explore the active ingredients and common targeting mechanism of its multi-pathway regulation of BS in treating depression and CRC, and to validate the dual effects of BS using the CUMS mice model and orthotopic transplantation tumor mice model of CRC...
March 11, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38478512/trend-of-estimated-participation-rate-by-regional-block-gender-and-age-group-in-the-1997-2019-national-health-and-nutrition-survey-in-japan
#26
JOURNAL ARTICLE
Midori Ishikawa, Osamu Hemmi, Hidemi Takimoto, Mai Matsumoto, Tetsuji Yokoyama
This study aimed to identify the trend of approximate participation rate in Japan's National Health and Nutrition Survey (NHNS_J). The proportion of participants among all residents of surveyed districts (estimated participation rate: EPR) was calculated by 12 regional blocks, gender, and age group, and the trend and annual percent change (APC) were clarified. Based on the 1997-2019 NHNS_J data, we created a database classified by prefecture, gender, and age group; in addition to these, the number of people per household by Population Census or population estimates were obtained from e-Stat and added to the database...
2024: PloS One
https://read.qxmd.com/read/38476907/pj%C3%A2-001-a-small%C3%A2-molecule-proteolysis%C3%A2-targeting-chimera-ameliorates-atopic-dermatitis%C3%A2-like-inflammation-in-mice-by-inhibiting-the-jak2-stat3-pathway-and-repairing-the-skin-barrier
#27
JOURNAL ARTICLE
Pei Lin, Zhendong Chen, Yinying Lu, Hongyu Shi, Jun Lin
Atopic dermatitis (AD) is a common allergic skin disease, and its pathogenesis involves genetic and environmental factors, as well as the immune response and skin barrier. PJ-001 is a small-molecule proteolysis-targeting chimera, which can degrade proteins related to the Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) pathway. In the present study, 0.5% 2,4-dinitrofluorobenzene was used to induce a mouse model of AD. Following treatment with PJ-001, the number of scratches and the severity of skin damage in the AD mice were recorded...
April 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38476894/effect-of-tofacitinib-on-the-phenotype-and-activity-of-caco%C3%A2-2-cells-in-a-model-of-inflammatory-bowel-disease
#28
JOURNAL ARTICLE
Estera Skudrzyk, Łukasz Bułdak, Grzegorz Machnik, Bogusław Okopień
Reports have indicated that autoimmune bowel disorders affect an increasing number of people on every continent; therefore, it is important to better understand inflammatory bowel disease (IBD) and to explore new treatment options for patients suffering from it. Research has indicated the important role of enterocytes in IBD. Understanding the role of the intestinal epithelium in the pathogenesis of IBD may contribute to a better understanding of the inflammatory processes and aid in the identification of potential therapeutic treatments...
April 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38474629/anti-inflammatory-effect-of-chamaecyparis-obtusa-siebold-zucc-endl-leaf-essential-oil
#29
JOURNAL ARTICLE
Sung-Hee Kim, Young-Ah Jang, Yong-Jin Kwon
Chamaecyparis obtusa (Siebold & Zucc.) Endl. ( C. obtusa ) belongs to the Cupressaceae family and is native to East Asian regions. Essential oils extracted from the leaves, bark, branches, and roots of C. obtusa have both aesthetic and medicinal properties and are thus widely used. However, detailed analyses of the active ingredients of C. obtusa extract are lacking. In this study, the sabinene content in the hydro-distillation of C. obtusa leaf essential oil (COD) was analyzed using GC-MS, and the anti-inflammatory effect of COD was compared with that of pure sabinene...
March 1, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38473879/identification-of-molecular-mechanisms-in-radiation-cystitis-insights-from-rna-sequencing
#30
JOURNAL ARTICLE
Sabrina Mota, Elijah P Ward, Sarah N Bartolone, Michael B Chancellor, Bernadette M M Zwaans
Pelvic cancer survivors who were treated with radiation therapy are at risk for developing (hemorrhagic) radiation cystitis (RC) many years after completion of radiation therapy. Patients with RC suffer from lower urinary tract symptoms, including frequency, nocturia, pelvic pain, and incontinence. In advanced stages, hematuria can occur, potentially escalating to life-threatening levels. Current therapeutic options for RC are limited, partly due to ethical concerns regarding bladder biopsy in patients with fragile bladder tissue...
February 23, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38473222/jak-inhibitors-in-cutaneous-t-cell-lymphoma-friend-or-foe-a-systematic-review-of-the-published-literature
#31
REVIEW
Seyed Mohammad Vahabi, Saeed Bahramian, Farzad Esmaeili, Bardia Danaei, Yasamin Kalantari, Patrick Fazeli, Sara Sadeghi, Nima Hajizadeh, Chalid Assaf, Ifa Etesami
Cutaneous T-cell lymphomas (CTCLs) are a group of lymphoid neoplasms with high relapse rates and no curative treatment other than allogeneic stem cell transplantation (allo-SCT). CTCL is significantly influenced by disruption of JAK/STAT signaling. Therefore, Janus kinase (JAK) inhibitors may be promising for CTCL treatment. This study is a systematic review aiming to investigate the role of JAK inhibitors in the treatment of CTCL, including their efficacy and safety. Out of 438 initially searched articles, we present 13 eligible ones...
February 21, 2024: Cancers
https://read.qxmd.com/read/38472658/socioeconomic-influences-on-outcomes-following-congenital-heart-disease-surgery
#32
JOURNAL ARTICLE
Kristin Schneider, Sarah de Loizaga, Andrew F Beck, David L S Morales, JangDong Seo, Allison Divanovic
Associations between social determinants of health (SDOH) and adverse outcomes for children with congenital heart disease (CHD) are starting to be recognized; however, such links remain understudied. We examined the relationship between community-level material deprivation on mortality, readmission, and length of stay (LOS) for children undergoing surgery for CHD. We performed a retrospective cohort study of patients who underwent cardiac surgery at our institution from 2015 to 2018. A community-level deprivation index (DI), a marker of community material deprivation, was generated to contextualize the lived experience of children with CHD...
March 12, 2024: Pediatric Cardiology
https://read.qxmd.com/read/38471648/polyphenols-synergistic-drugs-to-ameliorate-non-alcoholic-fatty-liver-disease-via-signal-pathway-and-gut-microbiota-a-review
#33
REVIEW
Hongcai Li, Jingjing Liang, Mengzhen Han, Zhenpeng Gao
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease with an increasing incidence worldwide. Single drug therapy may have toxic side effects and disrupt gut microbiota balance. Polyphenols are widely used in disease intervention due to their distinctive nutritional properties and medicinal value, which a potential gut microbiota modulator. However, there is a lack of comprehensive review to explore the efficacy and mechanism of combined therapy with drugs and polyphenols for NAFLD...
March 10, 2024: Journal of Advanced Research
https://read.qxmd.com/read/38471258/laboratory-testing-efficiency-during-the-covid-pandemic-findings-from-the-primary-health-care-corporation-laboratories-in-the-state-of-qatar
#34
JOURNAL ARTICLE
Sara Awwad, Mohammed Al-Hamdani, Atiyeh M Abdallah, Marawan Abu-Madi
BACKGROUND: Little is known about how the COVID-19 pandemic altered laboratory testing efficiency in the State of Qatar. The aim of this study was to assess laboratory testing efficiency with respect to the total number and proportion of C-reactive protein (CRP), complete blood count (CBC), and comprehensive metabolic panel (CMP) tests completed on time in 2019-2021 in several ordinary and COVID-converted Primary Health Care Corporation (PHCC) health centers across Qatar. METHODS: Secondary data from 2019 to 2021 were accessed from the PHCC-Clinical Information System center...
March 5, 2024: Journal of Infection and Public Health
https://read.qxmd.com/read/38469681/tofacitinib-ameliorates-skin-inflammation-in-a-case-of-severe-autosomal-recessive-congenital-ichthyosis
#35
JOURNAL ARTICLE
Yu-Chen Lin, Yi-Kai Hong, Wilson Jr F Aala, Kiyotaka Hitomi, Masashi Akiyama, John A McGrath, Chao-Kai Hsu
Autosomal recessive congenital ichthyosis (ARCI) is a genetically heterogeneous disorder manifesting aberrant skin scaling and increased transepidermal water loss (TEWL). Current treatments for ARCI are limited and sub-optimal. We studied a 27-year-old man with ARCI resulting from a homozygous missense variant in TGM1 (transglutaminase 1). RNA-sequencing of lesional skin revealed aberrant JAK-STAT signalling, providing a rationale for innovative treatment with a Janus kinase inhibitor. We prescribed oral tofacitinib (11 mg daily) for 26 weeks...
March 12, 2024: Clinical and Experimental Dermatology
https://read.qxmd.com/read/38466007/estragole-ameliorates-cfa-induced-rheumatoid-arthritis-symptoms-in-wistar-rats-by-inhibiting-jak-2-stat-3-pathway
#36
JOURNAL ARTICLE
J Zhang, D Wang, X Hu
The present study was conducted to scrutinize the pharmacological effect of Estragole (ESG) against CFA-induced arthritis in rats. The rats underwent induction of arthritis using the administration of CFA and after that, the rats were randomly divided into five different groups, where three groups correspond to diverse dosages of ESG, and the other two were control and CFA-arthritic control. Results of the study suggested that ESG in a dose-dependent manner, improves body weight and arthritis score of rats as evidenced by reduction of hind-paw volume...
March 11, 2024: Physiological Research
https://read.qxmd.com/read/38464736/role-of-stat3-in-pancreatic-cancer
#37
REVIEW
Zachary Hamel, Sierra Sanchez, David Standing, Shrikant Anant
Pancreatic cancer remains a serious and deadly disease, impacting people globally. There remain prominent gaps in the current understanding of the disease, specifically regarding the role of the signal transducer and activator of transcription (STAT) family of proteins in pancreatic tumors. STAT proteins, particularly STAT3, play important roles in pancreatic cancer, especially pancreatic ductal adenocarcinoma (PDAC), which is the most prevalent histotype. The role of STAT3 across a continuum of molecular processes, such as PDAC tumorigenesis and progression, immune escape, drug resistance and stemness, and modulation of the tumor microenvironment (TME), are only a tip of the iceberg...
2024: Exploration of targeted anti-tumor therapy
https://read.qxmd.com/read/38464510/pain-in-axial-spondyloarthritis-role-of-the-jak-stat-pathway
#38
REVIEW
Carlo Selmi, Maria Sole Chimenti, Lucia Novelli, Bhumik K Parikh, Francesca Morello, Kurt de Vlam, Francesco Ciccia
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease that is characterized by new bone formation in the axial musculoskeletal system, with X-ray discriminating between radiographic and non-radiographic forms. Current therapeutic options include non-steroidal anti-inflammatory drugs in addition to biological disease-modifying anti-rheumatic drugs that specifically target tumor necrosis factor-alpha (TNFα) or interleukin (IL)-17. Pain is the most critical symptom for axSpA patients, significantly contributing to the burden of disease and impacting daily life...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38462549/a-specific-inflammatory-suppression-fibroblast-subpopulation-characterized-by-mhcii-expression-in-human-dilated-cardiomyopathy
#39
JOURNAL ARTICLE
Xi Fan, Kai Huang, Yuming Wu, Sheng Jin, Liewen Pang, Yiqing Wang, Bo Jin, Xiaotian Sun
Dilated cardiomyopathy (DCM) is a significant cause of heart failure that requires heart transplantation. Fibroblasts play a central role in the fibro-inflammatory microenvironment of DCM. However, their cellular heterogeneity and interaction with immune cells have not been well identified. An integrative analysis was conducted on single-cell RNA sequencing (ScRNA-Seq) data from human left ventricle tissues, which comprised 4 hearts from healthy donors and 6 hearts with DCM. The specific antigen-presenting fibroblast (apFB) was explored as a subtype of fibroblasts characterized by expressing MHCII genes, the existence of which was confirmed by immunofluorescence staining of 3 cardiac tissues from DCM patients with severe heart failure...
March 10, 2024: Molecular and Cellular Biochemistry
https://read.qxmd.com/read/38461288/characterizing-neuroinflammation-and-identifying-prenatal-diagnostic-markers-for-neural-tube-defects-through-integrated-multi-omics-analysis
#40
JOURNAL ARTICLE
Wenshuang Wang, Yanhong Ji, Zhexu Dong, Zheran Liu, Shuang Chen, Lei Dai, Xiaolan Su, Qingyuan Jiang, Hongxin Deng
BACKGROUND: Neural Tube Defects (NTDs) are congenital malformations of the central nervous system resulting from the incomplete closure of the neural tube during early embryonic development. Neuroinflammation refers to the inflammatory response in the nervous system, typically resulting from damage to neural tissue. Immune-related processes have been identified in NTDs, however, the detailed relationship and underlying mechanisms between neuroinflammation and NTDs remain largely unclear...
March 9, 2024: Journal of Translational Medicine
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