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Red cell disorders

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https://www.readbyqxmd.com/read/29026752/hwa-hypoferritinemia-without-anemia-a-hidden-hematology-disorder
#1
Hassan A Al-Jafar
INTRODUCTION: Anemia is a condition, in which the number of red blood cells (RBC) and the hemoglobin (Hb) is insufficient to meet the body's physiologic needs. Hypoferritinemia without anemia (HWA) could cause masked clinical manifestations as general weakness, easy fatigability, depressed mode, and hair loss but with normal complete blood count (CBC) parameters. HWA is deferent from iron deficiency anemia (IDA) because there is no reduction in the RBC, Hb, or any of the other parameters of the CBC...
January 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29026589/a-retrospective-analysis-of-biochemical-and-haematological-parameters-in-patients-with-eating-disorders
#2
Leanne J Barron, Robert F Barron, Jeremy C S Johnson, Ingrid Wagner, Cameron J B Ward, Shannon R B Ward, Faye M Barron, Warren K Ward
BACKGROUND: The objective of the study was to determine whether levels of biochemical and haematological parameters in patients with eating disorders (EDs) varied from the general population. Whilst dietary restrictions can lead to nutritional deficiencies, specific abnormalities may be relevant to the diagnosis, pathogenesis and treatment of EDs. METHODS: With ethics approval and informed consent, a retrospective chart audit was conducted of 113 patients with EDs at a general practice in Brisbane, Australia...
2017: Journal of Eating Disorders
https://www.readbyqxmd.com/read/29026401/the-sensitivity-of-na-k-atpase-as-an-indicator-of-blood-diseases
#3
Abulnaja Kkalid Omar, Kherd Ali Ahmed, Nawal Mohammed Helmi, Kumosani Taha Abdullah, Mohamad H Qarii, Huwait Etimad Hasan, Albukhari Ashwag, Alaama Mohammed Nabil, Al-Ghamdi Maryam Abdu, Moselhy Said Salama
BACKGROUND: Blood-related hereditary diseases are widespread in Eastern and SouthWestern regions of Saudi Arabia until recently. In this study, we used Na(+), K(+)ATPase as an enzymatic indicator for the diagnosis of the diseases. MATERIALS AND METHODS: Individuals with different blood diseases (iron deficiency (n=13), anemia (n=14), thalassemia (n=16) and sickle cell anemia (n=12) were studied for Na(+), K(+)-ATPase activity in the plasma membrane of red blood cell and compared with those of the healthy ones (n=20) of the same age and gender living in Jeddah, Saudi Arabia...
March 2017: African Health Sciences
https://www.readbyqxmd.com/read/29024480/osmotic-gradient-ektacytometry-a-valuable-screening-test-for-hereditary-spherocytosis-and-other-red-blood-cell-membrane-disorders
#4
E Llaudet-Planas, J L Vives-Corrons, V Rizzuto, P Gómez-Ramírez, J Sevilla Navarro, M T Coll Sibina, M García-Bernal, A Ruiz Llobet, I Badell, P Velasco-Puyó, J L Dapena, M M Mañú-Pereira
INTRODUCTION: New generation osmotic gradient ektacytometry has become a powerful procedure for measuring red blood cell deformability and therefore for the diagnosis of red blood cell membrane disorders. In this study, we aim to provide further support to the usefulness of osmotic gradient ektacytometry for the differential diagnosis of hereditary spherocytosis by measuring the optimal cutoff values of the parameters provided by this technique. METHODS: A total of 65 cases of hereditary spherocytosis, 7 hereditary elliptocytosis, 3 hereditary xerocytosis, and 171 normal controls were analyzed with osmotic gradient ektacytometry in addition to the routine red blood cell laboratory techniques...
October 10, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29023059/hematological-and-mineral-profiles-of-reproductive-failure-of-exotic-breed-cattle-in-payakumbuh-west-sumatra-indonesia
#5
Yuherman, Reswati, Yulianti Fitri Kurnia, Indahwati, Khalil
BACKGROUND AND OBJECTIVE: Female exotic breed cattle raised by traditional small farms are susceptible to reproductive disturbances that result in failure or delay to produce calves. The present research investigated the hematologic profiles of exotic breed cattle having reproductive troubles versus heifers and pregnant cows raised by small farms. MATERIALS AND METHODS: A survey was conducted to identify the reproduction performance of 160 female Simmental cows raised at 15 smallholders in Payakumbuh, West Sumatra, Indonesia...
2017: Pakistan Journal of Biological Sciences: PJBS
https://www.readbyqxmd.com/read/29020838/safety-and-efficacy-of-aav5-vectors-expressing-human-or-canine-cngb3-in-cngb3-mutant-dogs
#6
Guo-Jie Ye, Andras M Komaromy, Caroline J Zeiss, Roberto Calcedo, Christine D Harman, Kristin L Koehl, Gabriel Stewart, Simone Iwabe, Vince Chiodo, William W Hauswirth, Gustavo Aguirre, Jeffrey David Chulay
Achromatopsia is an inherited retinal disorder of cone photoreceptors characterized by markedly reduced visual acuity, extreme light sensitivity and absence of color discrimination. Approximately 50% of cases are caused by mutations in the cone photoreceptor-specific cyclic nucleotide gated channel beta subunit (CNGB3) gene. Studies in CNGB3-mutant dogs showed that subretinal injection of an AAV vector expressing human CNGB3, which has 76% amino acid identity with canine CNGB3, driven by a 2.1 kb human red cone opsin promoter (PR2...
October 12, 2017: Human Gene Therapy. Clinical Development
https://www.readbyqxmd.com/read/29018971/csf-rbc-count-in-successful-first-attempt-lumbar-puncture-the-interest-of-atraumatic-needle-use
#7
Dimitri Renard, Eric Thouvenot
The objective of this study is to analyze CSF red blood cell (RBC) count from first-attempt lumbar punctures and to analyze parameters associated with first-attempt lumbar punctures and hemorrhagic lumbar puncture. This is a prospective analysis of consecutive patients who underwent lumbar puncture for any reason other than suspected acute subarachnoid hemorrhage. Analyzed parameters were the following: age, indication for lumbar puncture, aPTT ratio, PTT, platelet count, patient's position, needle type (atraumatic/standard), needle diameter, person performing lumbar puncture (medical student/resident/attending physician), number of lumbar levels punctured, necessity of needle repositioning, CSF RBC and white blood cell count, and protein level...
October 10, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29018767/optical-coherence-tomography-features-in-a-case-of-type-i-sialidosis
#8
I-Hua Wang, Ting-Yu Lin, Shu-Ting Kao
A 15-year-old boy presented with progressive myoclonic epilepsy and unbalance gaits for 4 years. Slit lamp examination showed a punctate cataract and funduscopic examination revealed bilateral macular cherry-red spots. Macular scan of spectral domain optical coherence tomography (SD-OCT) showed hyperreflectivity of the inner retinal layer and apparent hyperreflectivity of the photoreceptor layers in the foveal region. The clinical presentations were consistent with a Type I sialidosis which led to genetic analysis and revealed NEU1 mutation in this patient...
April 2017: Taiwan Journal of Ophthalmology
https://www.readbyqxmd.com/read/28992460/lipid-chain-saturation-and-the-cholesterol-in-the-phospholipid-membrane-affect-the-spectroscopic-properties-of-lipophilic-dye-nile-red
#9
Animesh Halder, Baishakhi Saha, Pabitra Maity, Gopinatha Suresh Kumar, Deepak Kumar Sinha, Sanat Karmakar
We have studied the effect of composition and the phase state of phospholipid membranes on the emission spectrum, anisotropy and lifetime of a lipophilic fluorescence probe nile red. Fluorescence spectrum of nile red in membranes containing cholesterol has also been investigated in order to get insights into the influence of cholesterol on the phospholipid membranes. Maximum emission wavelength (λem) of nile red in the fluid phase of saturated and unsaturated phospholipids was found to differ by ~10nm. The λem was also found to be independent of chain length and charge of the membrane...
October 5, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28991281/trombosis-venosa-espl%C3%A3-cnica-como-manifestaci%C3%A3-n-inicial-de-mielofibrosis-primaria
#10
Gregorio Campos-Cabrera, Virginia Campos-Cabrera, Salvador Campos-Cabrera, José-Luis Campos-Villagómez, Alejandra Romero-González
other: Las neoplasias mieloproliferativas (NMP) son alteraciones crónicas de las células madre hematopoyéticas clonales caracterizadas por una mayor producción de granulocitos, glóbulos rojos o plaquetas. Una de las principales complicaciones de las NMP es la aparición de problemas trombóticos venosos y arteriales causados por un aumento en la agregación plaquetaria y la generación de trombina. Se evaluaron 11 casos de mielofibrosis primaria (MP), de los cuales dos debutaron con trombosis venosa esplácnica (TVE)...
2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/28990532/a-novel-scn9a-mutation-f826y-in-primary-erythromelalgia-alters-the-excitability-of-nav1-7
#11
B Wu, Y Zhang, H Tang, Mei Yang, Hai Long, Gaoxing Shi, Jianguang Tang, Xiaoliu Shi
Primary erythromelalgia (PE) is a dominant inherited disorder characterized by recurrent pain, redness, and warmth of the extremities that is caused by gain-of-function mutations in the voltage-gated sodium channel Nav1.7. We investigated a three-generation Chinese Han family with PE. The proband is a 15-year old girl presented with skin ulcers, recurrent burning pain, warmth, and redness of the lower extremities that are refractory to all kinds of reported medications. The other two patients presented with similar symptoms but with far less severity that naturally remitted near their forties...
October 9, 2017: Current Molecular Medicine
https://www.readbyqxmd.com/read/28989807/red-blood-cell-distribution-width-and-ischaemic-stroke
#12
REVIEW
Gang-Hua Feng, Hai-Peng Li, Qiu-Li Li, Ying Fu, Ren-Bin Huang
The red blood cell distribution width (RDW) is a measure of red blood cell (RBC) size heterogeneity, which is easily calculated by dividing the SD of erythrocyte volumes for the mean corpuscular volume. Recent reporter suggested that, besides haematological diseases and anaemia, many human disorders may be closely associated with the elevated RDW. A literature review has revealed the RDW may be closely related to the development of ischaemic stroke, carotid artery atherosclerosis and cerebral embolism. Higher RDW could independently predict adverse outcomes in patients in these conditions...
September 2017: Stroke and Vascular Neurology
https://www.readbyqxmd.com/read/28988373/lithium-treatment-aggregates-the-adverse-effects-on-erythrocytes-subjected-to-arsenic-exposure
#13
Priti Bhardwaj, Kinnri Jain, Devinder Kumar Dhawan
The present study was designed to investigate the effects of lithium treatment on red blood cells which were given arsenic exposure. Long-term lithium therapy is being extensively used for the treatment of bipolar disorders. Arsenic is a group I carcinogen and a major toxic pollutant in drinking water that affects millions of people worldwide. Male SD rats were segregated into four groups, viz. normal control, lithium treated, arsenic treated, and lithium + arsenic treated. Lithium was supplemented as lithium carbonate at a dose level of 1...
October 7, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28983775/deficiency-of-adenosine-deaminase-2-dada2-an-inherited-cause-of-polyarteritis-nodosa-and-a-mimic-of-other-systemic-rheumatologic-disorders
#14
REVIEW
Hasan Hashem, Susan J Kelly, Nancy J Ganson, Michael S Hershfield
PURPOSE OF REVIEW: A new autoinflammatory disease, deficiency of adenosine deaminase 2 (DADA2), caused by mutations in the CECR1 gene, was first reported in 2014. This review aims to update progress in defining, treating, and understanding this multi-faceted disorder. RECENT FINDINGS: DADA2 was first described in patients with systemic inflammation, mild immune deficiency, and vasculopathy manifested as recurrent stroke or polyarteritis nodosa (PAN). More than 125 patients have now been reported, and the phenotype has expanded to include children and adults presenting primarily with pure red cell aplasia (PRCA), or with antibody deficiency...
October 5, 2017: Current Rheumatology Reports
https://www.readbyqxmd.com/read/28982592/human-amyloid-%C3%AE-peptide-and-tau-co-expression-impairs-behavior-and-causes-specific-gene-expression-changes-in-caenorhabditis-elegans
#15
Chenyin Wang, Valeria Saar, Ka Lai Leung, Liang Chen, Garry Wong
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the presence of extracellular amyloid plaques consisting of Amyloid-β peptide (Aβ) aggregates and neurofibrillary tangles formed by aggregation of hyperphosphorylated microtubule-associated protein tau. We generated a novel invertebrate model of AD by crossing Aβ1-42 (strain CL2355) with either pro-aggregating tau (strain BR5270) or anti-aggregating tau (strain BR5271) pan-neuronal expressing transgenic Caenorhabditis elegans...
October 2, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28981210/proteome-and-structural-organization-of-the-knob-complex-on-the-surface-of-the-plasmodium-infected-red-blood-cell
#16
ShubaVarshini Alampalli, Manish Grover, Syama Chandran, Utpal Tatu, Pragyan Achary
PURPOSE: The cell membrane of the erythrocytes infected with the malaria parasite Plasmodium falciparum undergoes several changes during the course of parasite life cycle and forms protrusions known as 'knobs' on its surface during the mature trophozoite and schizont stages. The structural organization of knob components especially PfEMP1 on the iRBC surface is the main determinant for the cytoadhesive and rosetting capacity of the iRBC by binding to various host receptors as well as for the variable antigenicity, which is crucial for immunoevasion...
October 5, 2017: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/28979628/determination-in-vivo-viability-of-a-transfused-platelet-product-by-corrected-count-increment-and-percentage-platelet-response
#17
Nancy Wanjiru Thuku, Kibet Shikuku, Amos Mbugua
INTRODUCTION: For many years, platelet concentrates have been used for the prevention as well as treatment of bleeding disorders, especially in those patients with haematological problems involving platelet disorders as well as refractoriness, In addition, platelet concentrates (PCs) have been widely used to support patients undergoing bone marrow transplantation or who are receiving myelotoxic treatments. The aim of this study was to determine the quality of platelet concentrates by assessing platelet counts, volume, pH changes, swirling, residue of the red blood cells and white blood cell counts...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28977053/large-accumulation-of-collagen-and-increased-activation-of-mast-cells-in-hearts-of-mice-with-hyperlipidemia
#18
Yunpeng Cheng, Yanqiu Zhu, Jiashu Zhang, Xingping Duan, Ying Zhang
BACKGROUND: Hyperlipidemia, which is characterized by an elevation of lipids in the bloodstream, is a major risk factor for cardiac disease. OBJECTIVES: The present study investigated the role of fibrosis in the progression of hyperlipidemia in the mice heart, and whether mast cell activation was associated with the fibrosis process. METHODS: Hyperlipidemia was produced in C57BL / 6 mice by feeding them on a high-fat diet for 8 weeks.To assess tissue fibrosis, picrosirius red staining was performed...
September 28, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28974772/piezos-thrive-under-pressure-mechanically-activated-ion-channels-in-health-and-disease
#19
REVIEW
Swetha E Murthy, Adrienne E Dubin, Ardem Patapoutian
Cellular mechanotransduction, the process of translating mechanical forces into biological signals, is crucial for a wide range of physiological processes. A role for ion channels in sensing mechanical forces has been proposed for decades, but their identity in mammals remained largely elusive until the discovery of Piezos. Recent research on Piezos has underscored their importance in somatosensation (touch perception, proprioception and pulmonary respiration), red blood cell volume regulation, vascular physiology and various human genetic disorders...
October 4, 2017: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/28974032/dietary-anthocyanins-against-obesity-and-inflammation
#20
REVIEW
Yoon-Mi Lee, Young Yoon, Haelim Yoon, Hyun-Min Park, Sooji Song, Kyung-Jin Yeum
Chronic low-grade inflammation plays a pivotal role in the pathogenesis of obesity, due to its associated chronic diseases such as type II diabetes, cardiovascular diseases, pulmonary diseases and cancer. Thus, targeting inflammation is an attractive strategy to counter the burden of obesity-induced health problems. Recently, food-derived bioactive compounds have been spotlighted as a regulator against various chronic diseases due to their low toxicity, as opposed to drugs that induce severe side effects. Here we describe the beneficial effects of dietary anthocyanins on obesity-induced metabolic disorders and inflammation...
October 1, 2017: Nutrients
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