Herath Mudiyanselage Udari Lakmini Herath, Mei Jing Piao, Kyoung Ah Kang, Pincha Devage Sameera Madushan Fernando, Jin Won Hyun
Particulate matter 2.5 (PM2.5 ) poses a serious threat to human health and is responsible for respiratory disorders, cardiovascular diseases, and skin disorders. 3-Bromo-4,5- dihydroxybenzaldehyde (3-BDB), abundant in marine red algae, exhibits anti-inflammatory, antioxidant, and anti-diabetic activities. In this study, we investigated the protective mechanisms of 3-BDB against PM2.5 -induced cell cycle arrest and autophagy in human keratinocytes. Intracellular reactive oxygen species (ROS) generation, DNA damage, cell cycle arrest, intracellular Ca2+ level, and autophagy activation were tested...
April 26, 2024: Molecules and Cells