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Ghaith Altawallbeh, Laura Smith, Stephen J Lewis, Simon Authier, Kim Bujold, Benjamin Gaston, Ilya Bederman
CONTEXT: Sudaxine is a novel respiratory stimulant that increases ventilatory drive via NO+ -thiolate signaling and is under development for reversal of opioid-induced respiratory depression and other critical care indications. OBJECTIVE: This study investigates the pharmacokinetic characteristics after intravenous administration of Sudaxine by using a simple LC-MS/MS method. MATERIALS AND METHODS: A sensitive LC-MS/MS method was validated to determine the concentration of Sudaxine in beagle dog plasma after intravenous administration of Sudaxine at (3, 10, 30 and 100 mg/kg)...
September 22, 2018: Drug Testing and Analysis
Shin Hye Park, Miranda Hanchett, Chenjuan Ma
PURPOSE: To examine which characteristics of the practice environment were associated with missed nursing care in U.S. acute care hospital units. DESIGN: A descriptive, correlational study used secondary analysis of the 2015 National Database of Nursing Quality Indicators® Registered Nurse (RN) Survey data. Subscales of the Practice Environment Scale of the Nursing Work Index were used to measure practice environment characteristics. The sample included 1,583 units in 371 hospitals, containing survey responses from 31,650 RNs...
September 22, 2018: Journal of Nursing Scholarship
Jian Wu, Xin Yan, Guoqiang Jin
Sepsis is usually accompanied by pulmonary inflammations, leading to acute lung injury. During this process, endogenous factors that play a regulatory role could be exploited to therapeutically alleviate such lethal tissue injury. Here, we showed that ulinastatin (UTI) administration could reduce lung tissue necrosis and swelling during sepsis in rats. UTI treatment also decreased the levels of inflammatory mediators both in the lung and in the serum. Mechanistically, we showed that the phosphorylation levels of JAK2 and STAT3 in the lung of UTI-treated rats were lower than control rats and were correlated with the decreased levels of inflammatory mediators...
September 22, 2018: Journal of Cellular Biochemistry
Yun Luan, Chao Sun, Jue Wang, Wen Jiang, Qian Xin, Zhaohua Zhang, Yibiao Wang
BACKGROUND: Baicalin can attenuate myocardial ischemia-reperfusion (I/R) on damage. However, the mechanisms are still not fully understood. The study aimed to investigate the antiapoptosis and anti-inflammatory effects of baicalin on myocardial I/R-induced injury. METHODS: We established male rats I/R model, and baicalin was intragastric administration after ischemia onset. All experimental animals were randomly divided into five groups: group I, sham; group II, I/R; group III, 50 mg/kg; group IV, 100 mg/kg; and group V, 200 mg/kg baicalin...
September 22, 2018: Journal of Cellular Biochemistry
Xiaowen Shi, Yasuyuki Ohta, Jingwei Shang, Ryuta Morihara, Yumiko Nakano, Yusuke Fukui, Xia Liu, Tian Feng, Yong Huang, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Toru Yamashita, Eriko Suzuki, Keiji Hasumi, Koji Abe
Stachybotrys microspora triprenyl phenol (SMTP)-44D has both anti-oxidative and anti-inflammatory activities, but its efficacy has not been proved in relation to the pathological changes of neurovascular unit (NVU) and neurovascular trophic coupling (NVTC) in ischemic stroke. Here, the present study was designed to assess the efficacies of SMTP-44D, moreover, compared with the standard neuroprotective reagent edaravone in ischemic brains. ICR mice were subjected to transient middle cerebral artery occlusion (tMCAO) for 60 min, SMTP-44D (10 mg/kg) or edaravone (3 mg/kg) was intravenously administrated through subclavian vein just after the reperfusion, and these mice were examined at 1, 3, and 7 d after reperfusion...
September 22, 2018: Journal of Neuroscience Research
Domenica Roberto, Laurence H Klotz, Vasundara Venkateswaran
BACKGROUND: Cannabinoids have demonstrated anticarcinogenic properties in a variety of malignancies, including in prostate cancer. In the present study, we explored the anti-cancer effects of the synthetic cannabinoid WIN 55,212-2 (WIN) in prostate cancer. METHODS: Established prostate cancer cells (PC3, DU145, LNCaP) were treated with varying concentrations of WIN. Cell proliferation was determined by the MTS assay. The anti-migration and anti-invasive potential of WIN was examined by the wound healing assay and the matrigel invasion assay...
September 21, 2018: Prostate
Thidarat Intararuchikul, Narudol Teerapattarakan, Ratchanee Rodsiri, Mayuree Tantisira, Gert Wohlgemuth, Oliver Fiehn, Rossarin Tansawat
Centella asiatica has been used as culinary vegetable or medicinal herb. In this study, hepatoprotective effect of the standardized extract of Centella asiatica (ECa233) in rotenone-treated rats was examined using a GC-MS based metabolomic approach. ECa233 contains >80% triterpenoids with a ratio of madecassoside to asiaticoside of 1.5(±0.5):1. Rats were randomly divided into three groups (with six rats/group): sham negative control, rotenone positive control, and the ECa233 test group. Rats in the ECa233 group received 10 mg/kg ECa233 orally for 20 days, followed by 2...
September 22, 2018: Biomedical Chromatography: BMC
Brittany J Ciepluch, Heather M Wilson-Robles, Medora B Pashmakova, Christine M Budke, Gary W Ellison, Kelley M Thieman Mankin
OBJECTIVE: To determine the influence of administering allogeneic blood products (ABP) on the progression of hemangiosarcoma in dogs. STUDY DESIGN: Multi-institutional, retrospective study. SAMPLE POPULATION: One hundred four dogs with hemangiosarcoma that survived until postoperative discharge from the hospital. METHODS: Medical records of dogs that had been operated on for hemoangiosarcoma were reviewed for signalment, presence of a hemoabdomen, presence of metastatic disease, and whether the dog had received chemotherapy or Yunnan Baiyao...
September 21, 2018: Veterinary Surgery: VS
Tamara L Grubb, Danielle Kurkowski, Deborah C Sellon, Kathy K Seino, Todd Coffey, Jennifer L Davis
Buprenorphine is absorbed following sublingual administration, which would be a low-stress delivery route in foals. However, the pharmacokinetics/pharmacodynamics are not described in foals. Six healthy foals <21 days of age participated in a blinded, randomized, 3-period, 5-sequence, 3-treatment crossover prospective study. Foals received 0.01-0.02 mg/kg buprenorphine administered SL or IV with an equivalent volume of saline administered by the opposite route. Blood was collected from the cephalic vein for pharmacokinetic analysis...
September 21, 2018: Journal of Veterinary Pharmacology and Therapeutics
Sonja Axmann, Karin Hummel, Katharina Nöbauer, Ebrahim Razzazi-Fazeli, Karin Zitterl-Eglseer
Devil's claw is used for the treatment of inflammatory symptoms and degenerative disorders in horses since many years, but without the substantive pharmacokinetic data. The pharmacokinetic parameters of harpagoside, the main active constituent of Harpagophytum procumbens DC ex Meisn., were evaluated in equine plasma after administration of Harpagophytum extract FB 8858 in an open, single-dose, two-treatment, two-period, randomized cross-over design. Six horses received a single dose of Harpagophytum extract, corresponding to 5 mg/kg BM harpagoside, and after 7 days washout period, 10 mg/kg BM harpagoside via nasogastric tube...
September 22, 2018: Journal of Veterinary Pharmacology and Therapeutics
Marta Tikhomirov, Błażej Poźniak, Andrzej Smutkiewicz, Marcin Świtała
The pharmacokinetics of florfenicol (FF) and thiamphenicol (TP) after single intravenous (IV) and oral (PO) administration was investigated in Mulard ducks. Both antibiotics were administered at a dose of 30 mg/kg body weight, and their concentrations in plasma samples were assayed using high-performance liquid chromatography with ultraviolet detection. Pharmacokinetic parameters were calculated using a noncompartmental method. After IV administration, significant differences were found for the mean residence time (2...
September 21, 2018: Journal of Veterinary Pharmacology and Therapeutics
Stewart J Tepper
Objective - To briefly describe the history of and available data on anti-calcitonin gene-related peptide (CGRP) therapies for headache. Background - CGRP was proposed as a target for primary headache therapies. Translational research involved moving from delineating the relationships between CGRP and primary headaches and the clinical development of anti-CGRP treatments. The first anti-CGRP treatment, an intravenous CGRP-receptor antagonist or gepant, olcegepant, was described as effective in terminating migraines in humans in 2004...
September 22, 2018: Headache
Rebekah Davis Reed, Erik L Antonsen
Humans exploring beyond low-Earth orbit face environmental challenges coupled with isolation, remote operations, and extreme resource limitations in which personalized medicine, enabled by genetic research, might be necessary for mission success. With little opportunity to test personalized countermeasures broadly, the National Aeronautics and Space Administration (NASA) will likely need to rely instead on collection of significant amounts of genomic and environmental exposure data from individuals. This need appears at first to be in conflict with the statutes and regulations governing the collection and use of genetic data...
September 1, 2018: AMA Journal of Ethics
M H Abaspour Aporvari, M Mamoei, S Tabatabaei Vakili, M Zareei, Navid Dadashpour Davachi
Zinc is an essential mineral and accepted as a trace element in the animal nutrition and for its role in biological enzymatic pathways. This study aimed to investigate the effect of oral administration of zinc oxide nanoparticles (ZnONPs) on some of the antioxidant parameters of semen plasma, quantitative and qualitative properties of Arabic ram sperm in the non-breeding season. Twelve adult Arabic rams (about 3-5 years old, 70 &plusmn;2.1 kg) were randomly assigned to receive one of the three levels of dietary ZnONPs (control; 0, group 1; 40 ppm and group 2; 80 ppm)...
June 2018: Archives of Razi Institute
Haijuan Zhi, Zhenwei Li, Yanping Deng, Peng Qi, Jinjun Hou, Wen Deng, Jinle Cheng, Wanying Wu, Dean Guo
Salvia miltiorrhiza, one of the most famous herbal medicines, is commonly used for the treatment of coronary heart diseases in China. Besides traditional decoction pieces, another relatively new product of S. miltiorrhiza, Ultrafine Granular Powder (D90 < 45 μm), is also increasingly used nowadays. In this paper, a UHPLC-LTQ-Orbitrap MS technique was developed for metabolite profile study after oral administration of Ultrafine Granular Powder (UGP) and Traditional Decoction Slices (TDS) of S. miltiorrhiza...
September 21, 2018: Biomedical Chromatography: BMC
Doha Yahia, Yasmin O El-Amir, Doaa S Abd El-Maguid, Eman E Elsharkawy
This study aimed to investigate the toxic impact prompted in the testes of adult mice exposed to 2,3,7,8-tetrachlorodibenzofuran (TCDF). Four groups of 12 mice each were used in the present study. Group 1 mice were kept as control and administered corn oil only. Group 2 animals were given glutathione (GSH) in a dose of 100 mg/kg body weight by oral gavage twice a week. Group 3 was given TCDF orally twice per week, in a dose of 0.5 μg/kg body weight for 8 weeks. Group 4 was administered GSH orally in a dosage of 100 mg/kg body weight plus TCDF twice a week for 8 weeks...
September 21, 2018: Environmental Science and Pollution Research International
Chenia Caldeira Martinez, Tássia Tonon, Tatiéle Nalin, Lilia Farret Refosco, Carolina Fischinger Moura de Souza, Ida Vanessa Doederlein Schwartz
Hepatic glycogen storage diseases (GSDs) are inborn errors of metabolism whose dietary treatment involves uncooked cornstarch administration and restriction of simple carbohydrate intake. The prevalence of feeding difficulties (FDs) and orofacial myofunctional disorders (OMDs) in these patients is unknown. OBJECTIVE: To ascertain the prevalence of FDs and OMDs in GSD. METHODS: This was a cross-sectional, prospective study of 36 patients (19 males; median age, 12...
September 22, 2018: JIMD Reports
Emran Habibi, Mohammad Shokrzadeh, Amirhossein Ahmadi, Aroona Chabra, Farshad Naghshvar, Hamed Haghi-Aminjan, Fatemeh Salehi
OBJECTIVE: To evaluate the protective effect of Zataria multiflora extract, an antioxidative medicinal plant, against cyclophosphamide (CP)-induced oxidative lung damage in mice. METHODS: Mice were intraperitoneally pre-treated with various doses of Zataria multiflora extract (50, 100, 200, and 400 mg/kg) once daily for 7 consecutive days. Animals were then injected with a single 200 mg/kg intraperitoneal dose of CP 1 h after the last administration of O. vulgare...
September 22, 2018: Chinese Journal of Integrative Medicine
Marius Marc-Daniel Mader, Patrick Czorlich, Christina König, Valentin Fuhrmann, Stefan Kluge, Manfred Westphal, Jörn Grensemann
BACKGROUND: Vancomycin and meropenem are frequently used as empiric treatment for ventriculitis. Penetration into the cerebrospinal fluid (CSF) depends on various factors with a high inter-individual variability. Because attaining and maintaining adequate concentrations of meropenem and vancomycin in the CSF is crucial for their bactericidal effect, we introduced a routine therapeutic drug monitoring (TDM) from CSF and serum for both antibiotics. We studied the antibiotic penetration into the CSF...
September 21, 2018: Acta Neurochirurgica
Keisuke Jimbo, Yutaka Itsuji, Erika Kubo, Masamichi Kumagai, Kuniharu Masui, Yoshiro Yamamura
PURPOSE: Intravenous administration of the brand formulation of rocuronium bromide, currently used as a muscle relaxant, has been associated with vascular pain accompanied by withdrawal movements of the arm and wrist. The purpose of this study was to identify the cause of vascular pain induced by the brand formulation and to develop a new rocuronium formulation, not causing vascular pain, using a vascular pain-evoked flexor reflex response model of anesthetized rats. METHODS: A rat flexor reflex model, monitored by electromyography, was used to evaluate a flexor reflex response as the index of vascular pain...
September 21, 2018: Journal of Anesthesia
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