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https://www.readbyqxmd.com/read/29929196/cpg-odn-a-tlr9-agonist-aggravates-myocardial-ischemia-reperfusion-injury-by-activation-of-tlr9-p38-mapk-signaling
#1
Liang Xie, Songqing He, Na Kong, Ying Zhu, Yi Tang, Jianhua Li, Zhengbing Liu, Jing Liu, Jianbin Gong
BACKGROUND/AIMS: Toll-like receptors (TLRs) have been implicated in myocardial ischemia/ reperfusion (I/R) injury. We examined the effect of CpG-oligodeoxynucleotide (ODN) on myocardial I/R injury. METHODS: Male Sprague-Dawley rats were treated with either CpG-ODN or control ODN 1 h prior to myocardial ischemia (30 min) followed by reperfusion. Rats treated with phosphate-buffered saline (PBS) served as I/R controls (n = 8/group). Infarct size was determined by 2,3,5-triphenyltetrazolium chloride and Evans blue straining...
June 19, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29929186/increased-fatty-acid-oxidation-in-differentiated-proximal-tubular-cells-surviving-a-reversible-episode-of-acute-kidney-injury
#2
Aurélien Bataille, Pierre Galichon, Nadjim Chelghoum, Badreddine Mohand Oumoussa, Marie-Julia Ziliotis, Iman Sadia, Sophie Vandermeersch, Noémie Simon-Tillaux, David Legouis, Raphaël Cohen, Yi-Chun Xu-Dubois, Morgane Commereuc, Eric Rondeau, Stéphane Le Crom, Alexandre Hertig
BACKGROUND/AIMS: Fatty acid oxidation (FAO), the main source of energy produced by tubular epithelial cells in the kidney, was found to be defective in tubulo-interstitial samples dissected out in kidney biopsies from patients with chronic kidney disease (CKD). Experimental data indicated that this decrease was a strong determinant of renal fibrogenesis, hence a focus for therapeutic interventions. Nevertheless, whether persistently differentiated renal tubules, surviving in a pro-fibrotic environment, also suffer from a decrease in FAO, is currently unknown...
June 19, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29929185/spectral-domain-optical-coherence-tomography-allows-the-unification-of-clinical-decision-making-for-the-evaluation-of-choroidal-neovascularization-activity
#3
Cornelia Volz, Felix Grassmann, Roman Greslechner, David Arthur Märker, Patrick Peters, Horst Helbig, Maria-Andreea Gamulescu
PURPOSE: This prospective observational clinical study investigated the benefits of spectral domain optical coherence tomography for specialists and residents in the management of neovascular age-related macular degeneration (AMD). PROCEDURES: The study involved 49 eyes of 44 patients. Patients were advised to present for reevaluation 4 weeks after the administration of the loading dose of vascular endothelial growth factor (VEGF)-inhibitors (3 intravitreal injections every 4 weeks after diagnosis)...
June 21, 2018: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/29929167/a-survey-on-chimeric-ureb-229-561-hpaa-protein-targeting-helicobacter-pylori-computational-and-in-vitro-urease-activity-valuation
#4
Alireza Salimi Chirani, Mona Ghazi, Mehdi Goudarzi, Shahin Najar Peerayeh, Hoorieh Soleimanjahi, Masoud Dadashi, Bahareh Hajikhani
Helicobacter pylori (H. pylori) as microaerophilic, Gram-negative bacterium colonize the human gastric milieu, where it impetuses chronic disorders. Vaccination is a complementary plan, along with antibiotic therapy, for clearance of H. pylori. Today, Computer based tools are essential for the evaluation, design, and experiment for novel chimeric targets for immunological administration. The purpose of this experiment was immunoinformatic analysis of UreB and HpaA molecules in a fusion arrangement and also, construction and expression of recombinant protein containing chimeric sequences...
May 5, 2018: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29929141/performance-of-two-differently-designed-permeable-reactive-barriers-with-sulfate-and-zinc-solutions
#5
Norma Pérez, Alex O Schwarz, Esteban Barahona, Pamela Sanhueza, Isabel Diaz, Homero Urrutia
For the first time, this laboratory-scale study evaluates the feasibility of incorporating diffusive exchange in permeable reactive barriers. In order to do this, the performance of two permeable reactive barriers (PRB) with different internal substrate arrangements were compared during the administration of a sulfate solution without metals (for 163 days) and with metals (for 60 days), simulating groundwater contaminated with acid mine drainage (AMD). In order to simulate a traditional PRB, a homogeneous distribution was implemented in the first reactor and the other PRB reactor utilized diffusion-active technology (DAPRB)...
June 18, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29929117/psychiatric-comorbidity-increases-mortality-in-immune-mediated-inflammatory-diseases
#6
Ruth Ann Marrie, Randy Walld, James M Bolton, Jitender Sareen, Scott B Patten, Alexander Singer, Lisa M Lix, Carol A Hitchon, Renée El-Gabalawy, Alan Katz, John D Fisk, Charles N Bernstein
OBJECTIVE: We determined the association between any common mental disorder (CMD: depression, anxiety disorder, bipolar disorder) and mortality and suicide in three immune-mediated inflammatory diseases (IMID), inflammatory bowel disease (IBD), multiple sclerosis (MS) and rheumatoid arthritis (RA), versus age-, sex- and geographically-matched controls. METHODS: Using administrative data, we identified 28,384 IMID cases (IBD: 8695; MS: 5496; RA: 14,503) and 141,672 matched controls...
June 7, 2018: General Hospital Psychiatry
https://www.readbyqxmd.com/read/29929036/evaluation-of-common-housekeeping-proteins-under-ischemic-conditions-and-or-rt-pa-treatment-in-bend-3-cells
#7
Pau Comajoan, Carme Gubern, Gemma Huguet, Joaquín Serena, Elisabet Kádár, Mar Castellanos
Thrombolysis with recombinant tissue plasminogen activator (rt-PA) is the only pharmacological approved treatment for ischemic stroke, despite its associated increasing risk of hemorrhagic transformation. Since many of rt-PA effects in blood-brain barrier (BBB) are not well characterized, the study of protein changes in BBB cells after rt-PA administration may help to understand its adverse effects. Our aim was to analyze protein levels of four commonly used housekeeping proteins: β-Actin, α-Tubulin, GAPDH and HPRT in bEnd...
June 18, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29928956/comparison-of-right-and-left-ventricular-enhancement-times-using-a-microbubble-contrast-agent-between-proximal-humeral-intraosseous-access-and-brachial-intravenous-access-during-cardiopulmonary-resuscitation-in-adults
#8
Yongchul Cho, Yeonho You, Jung Soo Park, Jin Hong Min, Insool Yoo, Wonjoon Jeong, Seung Ryu, Jinwoong Lee, Seungwhan Kim, Sung Uk Cho, Se Kwang Oh, Junwan Lee, Hong Joon Ahn
AIM: The present study aimed to compare the ventricular enhancement time between humeral intraosseous access (HIO) and brachial intravenous access (BIV) during cardiopulmonary resuscitation (CPR) in adult humans. To our knowledge, this is the first such study during CPR in adult humans. METHODS: This prospective single-centre observational cohort study assessed the medical records of patients who underwent CPR between January 2018 and March 2018. The primary endpoints were the left and right ventricular enhancement (LVE and RVE, respectively) times after administration of a microbubble contrast agent via HIO or BIV...
June 18, 2018: Resuscitation
https://www.readbyqxmd.com/read/29928944/protective-effects-of-apigenin-on-lps-induced-endometritis-via-activating-nrf2-signaling-pathway
#9
Pei-Yue Jiang, Xiao-Jun Zhu, Yi-Na Zhang, Fei-Fei Zhou, Xiao-Fu Yang
Endometritis is a puzzling disease that often associates with severe pelvic pain. In this study, we aimed to detect whether apigenin had protective effect against LPS-induced endometritis, if so, the underlying mechanism was further investigated. Apigenin was administrated 1 h before LPS treatment. The levels of inflammatory cytokines were measured by ELISA. The expression of NF-κB and Nrf2 were detected by Western blot analysis. The results showed that LPS treatment induced severe histological alteration of uterus and this change was attenuated by the treatment of apigenin...
June 18, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29928896/an-fxr-agonist-reduces-bile-acid-synthesis-independently-of-increases-in-fgf19-in-healthy-volunteers
#10
Amani Al-Khaifi, Mats Rudling, Bo Angelin
Bile acid (BA) synthesis is regulated through suppression of hepatic cholesterol 7α-hydroxylase via FXR activation in hepatocytes and/or enterocytes; in enterocytes, this process requires FGF19 signaling. To study these pathways, we quantified markers of BA synthesis (7α-hydroxy-4-cholesten-3-one;C4) and cholesterol production (lathosterol), FGF19, and BAs in serum from healthy male volunteers given 1 oral dose of the nonsteroidal FXR agonist Px-102 (0.15mg/kg, 0.3mg/kg, 0.6mg/kg, 1.12mg/kg, 2.25mg/kg, 3...
June 18, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29928895/hdl-apoa-i-induces-the-expression-of-angiopoietin-like-4-angptl4-in-endothelial-cells-via-a-pi3k-akt-foxo1-signaling-pathway
#11
Dimitris Theofilatos, Panagiotis Fotakis, Efi Valanti, Despina Sanoudou, Vassilis Zannis, Dimitris Kardassis
BACKGROUND: High Density Lipoprotein (HDL) and its main protein component, apolipoprotein A-I (apoA-I) have numerous atheroprotective functions on various tissues including the endothelium. Therapies based on reconstituted HDL containing apoA-I (rHDL-apoA-I) have been used successfully in patients with acute coronary syndrome, peripheral vascular disease or diabetes but very little is known about the genomic effects of rHDL-apoA-I and how they could contribute to atheroprotection. OBJECTIVE: The present study aimed to understand the endothelial signaling pathways and the genes that may contribute to rHDL-apoA-I-mediated atheroprotection...
June 18, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29928887/lipopolysaccharide-mediated-inflammatory-priming-potentiates-painful-post-traumatic-trigeminal-neuropathy
#12
Yves Boucher, Nathan Moreau, Annie Mauborgne, Wisam Dieb
We explored the molecular and behavioral effects of a perineural Lipopolysaccharide (LPS)-mediated inflammatory priming on the development and maintenance of painful post-traumatic trigeminal neuropathy (PPTTN) following infra-orbital nerve chronic constriction injury (CCI-IoN) in rats. Rats were pretreated with repetitive perineural injections in the vicinity of the IoN of either LPS or vehicle (Vhcl) before being submitted to CCI-IoN. Orofacial pain-like behaviors (response to Von Frey Filament testing and spontaneous isolated face grooming) were measured during the period of LPS injections (three weeks) and following CCI-IoN surgery (two weeks)...
June 18, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29928776/lower-blood-alcohol-concentration-among-hiv-positive-versus-hiv-negative-individuals-following-controlled-alcohol-administration
#13
Paul A Shuper, Narges Joharchi, Jürgen Rehm
BACKGROUND: Although it has been purported that HIV-positive individuals may experience a greater degree of intoxication than HIV-negative individuals following acute alcohol consumption, no research to date has empirically tested this supposition. The present investigation entailed a randomized controlled experiment to identify whether the administration of a weight-specified dose of alcohol would lead to differential blood alcohol concentrations (BACs) among HIV-positive versus HIV-negative men...
June 21, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29928764/inhomogeneous-down-regulation-of-i-na-underlies-piceatannol-pro-arrhythmic-mechanism-in-regional-ischemia-reperfusion
#14
Po-Cheng Chang, Yu-Chang Huang, Hui-Ling Lee, Gwo-Jyh Chang, Yen Chu, Ming-Shien Wen, Chung-Chuan Chou
BACKGROUND: Piceatannol, a grape-derived polyphenol, has been linked to pro-arrhythmic properties by aggravating inhomogeneous conduction delay in the ischemia-reperfusion (IR) zone to enhance arrhythmogenic alternans in heart failure (HF) rabbits. The underlying molecular mechanisms of piceatannol-induced conduction disturbance were unclear in this model. METHODS: HF was induced by 4-weeks rapid ventricular pacing. IR injury was induced in vivo using a protocol of left coronary artery ligation and release...
June 21, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29928702/phase-i-and-ii-trial-on-infusional-5-fluorouracil-and-gefitinib-in-combination-with-preoperative-radiotherapy-in-rectal-cancer-10-years-median-follow-up
#15
Maria Antonietta Gambacorta, Antonino De Paoli, Marco Lupattelli, Giuditta Chiloiro, Angela Pia Solazzo, Brunella Barbaro, Sergio Alfieri, Fabio Maria Vecchio, Jacopo Lenkowicz, Francesco Navarria, Elisa Palazzari, Giulio Bertola, Alessandro Frattegiani, Bruce Minsky, Vincenzo Valentini
Purpose: The aim of this study is to evaluate the long term survival of the addition of gefitinib to chemoradiotherapy (CRT) in locally advanced rectal cancer (LARC). Methods and materials: This previously published multicentre, open-label, phase I-II study, enrolled patients (pts) with LARC to receive CRT with concurrent 5-fluorouracil continuous intravenous infusion and a dose escalation of orally administered gefitinib, followed 6-8 weeks later by surgery. An intra-operative radiotherapy boost of 10 Gy was planned...
March 2018: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29928700/identification-of-the-active-portion-of-the-ccl3-derivative-reported-to-induce-antitumor-abscopal-effect
#16
Tomoko Tsuchiya, Kenshiro Shiraishi, Keiichi Nakagawa, Jae-Ryong Kim, Shiro Kanegasaki
Background and purpose: Intravenous administration of a single amino acid-substituted chemokine CCL3 derivative named eMIP elicits the abscopal effect (an effect distal to the target), after local irradiation at a tumor-bearing site. To distinguish the active portion of eMIP, we tested the antitumor activity of chemically synthesized partial peptides of eMIP. Synthetic peptide has various advantages in its clinical application. Material and methods: Colon26 adenocarcinoma cells were implanted subcutaneously in the right and left flanks of mice...
March 2018: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29928668/mesenteric-adipose-derived-stromal-cells-from-crohn-s-disease-patients-induce-protective-effects-in-colonic-epithelial-cells-and-mice-with-colitis
#17
Jill M Hoffman, Aristea Sideri, Jonathan J Ruiz, Dimitris Stavrakis, David Q Shih, Jerrold R Turner, Charalabos Pothoulakis, Iordanes Karagiannides
Mesenteric adipose tissue hyperplasia is a hallmark of Crohn's disease (CD). Recently, we showed that mesenteric adipose-derived stromal cells (ADSCs) from CD, ulcerative colitis, and control patients synthesize and release adipokines in a disease-dependent manner. Here we examined the expression profiles of CD and control patient-derived mesenteric ADSCs and studied the effects of their extracellular mediators on colonocyte signaling in vitro and experimental colitis in vivo. ADSCs were isolated from mesenteric fat of control and CD patients...
2018: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29928660/rho-kinase-inhibitors-do-not-expand-hematoma-volume-in-acute-experimental-intracerebral-hemorrhage
#18
Murtaza Akhter, Tom Qin, Paul Fischer, Homa Sadeghian, Hyung Hwan Kim, Michael J Whalen, Joshua N Goldstein, Cenk Ayata
Rho-associated kinase (ROCK) is an emerging target in acute ischemic stroke. Early pre-hospital treatment with ROCK inhibitors may improve their efficacy, but their antithrombotic effects raise safety concerns in hemorrhagic stroke, precluding use prior to neuroimaging. Therefore, we tested whether ROCK inhibition affects the bleeding times, and worsens hematoma volume in a model of intracerebral hemorrhage (ICH) induced by intrastriatal collagenase injection in mice. Tail bleeding time was measured 1 h after treatment with isoform-nonselective inhibitor fasudil, or ROCK2-selective inhibitor KD025, or their vehicles...
June 2018: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29928620/the-future-of-male-contraception-a-fertile-ground
#19
REVIEW
Iyad Khourdaji, Jacqueline Zillioux, Kevin Eisenfrats, Daniel Foley, Ryan Smith
The continued and rapid expansion of the Earth's population mandates the need for safe and effective measures of contraception. While a plethora of options exist for women, methods of contraception for the male partner are limited to condoms and vasectomy. The sequela of this discrepancy has led to the family planning burden falling disproportionately on the female partner. For the past several decades, extensive research has been undertaken exploring the feasibility of hormonal male contraception. This proposed method of contraception has focused on suppressing spermatogenesis by exploiting the hypothalamic-pituitary-gonadal (HPG) axis...
May 2018: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29928506/acute-pneumonitis-following-breast-silicone-liquid-injection
#20
Noni Novisari Soeroso, Ella Rhinsilva, Luhur Soeroso
Silicone injections, although well known for their adverse effect, are still widely used around the world. Pneumonitis after an injection of silicone liquid has been reported in several patients. Silicone liquid injection is frequently administered to transgender individuals into the buttocks area but is rarely used for the breasts. We report a case of presumed pneumonitis following breast silicone liquid injection. A 36-year-old woman was admitted due to shortness of breath three days after silicone liquid injection...
August 2018: Respirology Case Reports
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