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fMRI acupuncture

Chunhui Bao, Di Wang, Peng Liu, Yin Shi, Xiaoming Jin, Luyi Wu, Xiaoqing Zeng, Jianye Zhang, Huirong Liu, Huangan Wu
Acupuncture and moxibustion have been shown to be effective in treating Crohn's disease (CD), but their therapeutic mechanisms remain unclear. Here we compared brain responses to either electro-acupuncture or moxibustion treatment in CD patients experiencing remission. A total of 65 patients were randomly divided into an electro-acupuncture group (n = 32) or a moxibustion group (n = 33), and treated for 12 weeks. Eighteen patients in the electro-acupuncture group and 20 patients in the moxibustion group underwent resting-state functional magnetic resonance imaging at baseline and after treatment...
2017: Frontiers in Human Neuroscience
Wen-Ying Shi, Ping Li, Xiao-Rong Chang, Bi-Dan Lou, Jin-Xiang Li, Jie Huang, Lei Fan, Rong Luo, Ding Liu, Wei Zhang
OBJECTIVE: To observe the changes of brain rest-state functional connectivity following electroacupuncture (EA) stimulation of right Xia-Jiquan (HT 1), Shaohai (HT 3), Lingdao (HT 4) and Shenmen (HT 7) of the Heart Meridian and non-acupoints in healthy volunteers so as to provide an imaging basis for clinical treatment of some related disorders. METHODS: A total of 20 healthy volunteers who met the inclusion criteria were randomly divided into HT-acupoint group (n=10 cases) and non-acupoint group (n=10 cases) according to the visiting sequence...
June 25, 2017: Zhen Ci Yan Jiu, Acupuncture Research
Shuyong Liu, Min Li, Weijun Tang, Guangbin Wang, Yinghui Lv
Objective Functional magnetic resonance imaging (fMRI) analysis of the effects of acupuncturing the Tongli (HT5) and Tongli (HT5)-Xuanzhong (GB39) acupoints on the normal language areas with a view to providing a theoretical basis for using acupuncture to treat patients with aphasia. Methods This study enrolled healthy volunteers. The following acupoints were stimulated: right Tongli (HT5), right Tongli (HT5)-Xuanzhong (GB39), right Tongli (HT5) sham acupuncture, left Tongli (HT5), and left Tongli (HT5)-Xuanzhong (GB39) acupoints...
January 1, 2017: Journal of International Medical Research
Zhengjie Li, Fang Zeng, Tao Yin, Lei Lan, Nikos Makris, Kristen Jorgenson, Taipin Guo, Feng Wu, Yujie Gao, Mingkai Dong, Mailan Liu, Jie Yang, Ying Li, Qiyong Gong, Fanrong Liang, Jian Kong
Migraine is a common neurological disease with a high prevalence and unsatisfactory treatment options. The specific pathophysiological mechanisms of migraine remain unclear, which restricts the development of effective treatments for this prevalent disorder. The aims of this study were to 1) compare the spontaneous brain activity differences between Migraine without Aura (MwoA) patients and healthy controls (HCs), using amplitude of low-frequency fluctuations (ALFF) calculation method, and 2) explore how an effective treatment (verum acupuncture) could modulate the ALFF of MwoA patients...
2017: NeuroImage: Clinical
Yanzhe Ning, Kuangshi Li, Caihong Fu, Yi Ren, Yong Zhang, Hongwei Liu, Fangyuan Cui, Yihuai Zou
Increasing neuroimaging researches in stroke rehabilitation had revealed the neural mechanisms of rehabilitation therapy. However, little was known about the neural mechanisms of acupuncture therapy in subcortical stroke patients. The aim of this study was to investigate the changes of functional connectivity (FC) between the bilateral primary motor cortices (M1s) after acupuncture intervention in right subcortical stroke patients. Twenty right-hemispheric subcortical stroke patients and 20 healthy subjects were recruited to undergo one functional magnetic resonance imaging (fMRI) scanning...
2017: Frontiers in Human Neuroscience
Chae Ha Yang, Seong Hun Choi, Ju Sang Kim, Yeon Hee Ryu, Young Jin Lim, Moon Seup Kim, Jeong Woo Sohn, Sung Suk Oh, Cheongtag Kim, Mi Young Lee
We attempted to investigate whether acupuncture stimulation at HT7 can have an effect on brain activation patterns and alcohol abstinence self-efficacy. Thirty-four right-handed healthy subjects were recruited for this study. They were randomly assigned into two groups: the HT7 (Shenmen) group and the LI5 (Yangxi) group. Acupuncture stimulation was performed using a block paradigm during fMRI scanning. Additionally, the Korean version of Alcohol Abstinence Self-Efficacy Scale (AASES) was used to determine the effect of acupuncture stimulation on self-efficacy to abstain from alcohol use...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
Yanjie Wang, Yu Zheng, Shanshan Qu, Jiping Zhang, Zheng Zhong, Jialing Zhang, Huanlin Huang, Miaokeng Li, Yiwen Xu, Junqi Chen, Lei Wang, Genevieve Zara Steiner, Chunzhi Tang, Yong Huang
The study attempted to explore that the synergistic effect of acupoints combination is not a simple superposition of single acupoint's effect by comparing and analyzing the changes of blood pressure (BP), SF-36, and brain regions after acupuncture treatment. 47 patients were randomly divided into LR3+KI3 group, LR3 group, and KI3 group. Subjects received Rs-fMRI scan, BP measurement, and SF-36 questionnaires before and after treatment and short-term acupuncture treatment. After treatment, there were no significant differences in BP and SF-36 among 3 groups, compared to the case before treatment, SBP of 3 groups decreased, and DBP significantly decreased while vitality and mental health significantly increased in LR3+KI3 group...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
Xiaoyun Wang, Zengjian Wang, Jian Liu, Jun Chen, Xian Liu, Guangning Nie, Joon-Seok Byun, Yilin Liang, Joel Park, Ruiwang Huang, Ming Liu, Bo Liu, Jian Kong
As a widely-applied alternative therapy, acupuncture is gaining popularity in Western society. One challenge that remains, however, is incorporating it into mainstream medicine. One solution is to combine acupuncture with other conventional, mainstream treatments. In this study, we investigated the combination effect of acupuncture and the antidepressant fluoxetine, as well as its underlying mechanism using resting state functional connectivity (rsFC) in patients with major depressive disorders. Forty-six female depressed patients were randomized into a verum acupuncture plus fluoxetine or a sham acupuncture plus fluoxetine group for eight weeks...
2016: NeuroImage: Clinical
Zengjian Wang, Xiaoyun Wang, Jian Liu, Jun Chen, Xian Liu, Guangning Nie, Kristen Jorgenson, Ki Cheul Sohn, Ruiwang Huang, Ming Liu, Bo Liu, Jian Kong
Major depressive disorder (MDD) is a common disorder with a high prevalence and significant social and economic impacts. Nevertheless, the treatment of MDD is far from satisfactory. Acupuncture treatment has emerged as a promising method for treating MDD. However, the neural mechanism by which acupuncture reduces depressive symptoms is not fully understood. Studies have shown that the corticostriatal reward circuitry is associated with the pathophysiology of MDD; thus, we investigated the corticostriatal resting-state functional connectivity (rsFC) before and after real and sham acupuncture treatments combined with the antidepressant fluoxetine...
January 2017: Journal of Psychiatric Research
Yu Zheng, Jiping Zhang, Yanjie Wang, Yuying Wang, Yujun Lan, Shanshan Qu, Chunzhi Tang, Yong Huang
The therapeutic effects of acupuncture in decreasing blood pressure are ambiguous and underlying acupuncture in hypertension treatment has not been investigated. Our objective was to observe the change of quality of life and compare the differences in brain functional connectivity by investigating instantaneous and short-term acupuncture treatment in essential hypertension patients. A total of 30 patients were randomly divided into the LR3 group and sham acupoint group. Subjects received resting-state fMRI among preacupuncture, postinstantaneous, and short-term acupuncture treatment in two groups...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
Jian Lv, Changzheng Shi, Yanjia Deng, Wutao Lou, Jing Hu, Lin Shi, Liangping Luo, Defeng Wang
Acupuncture at thirteen ghost acupoints (TGA) was an effective treatment of neuropsychological disorders. However, the underlying neurological mechanisms of acupuncture at the TGA have not been revealed by modern scientific technologies. As laser acupuncture emerges with the painless and noninvasive advantages and the functional magnetic resonance imaging (fMRI) allows us to investigate the activation of the brain in vivo, we performed the preliminary study to investigate the relation to brain effects of acupuncture at TGA based on resting-state fMRI (rs-fMRI)...
December 2016: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
Till Nierhaus, Daniel Pach, Wenjing Huang, Xiangyu Long, Vitaly Napadow, Stephanie Roll, Fanrong Liang, Burkhard Pleger, Arno Villringer, Claudia M Witt
No abstract text is available yet for this article.
2016: Frontiers in Human Neuroscience
María Villarreal Santiago, Steve Tumilty, Aleksandra Mącznik, Ramakrishnan Mani
Acupuncture has been studied for several decades to establish evidence-based clinical practice. This systematic review aims to evaluate evidence for the effectiveness of acupuncture in influencing the functional connectivity of the central nervous system in patients with musculoskeletal pain. A systematic search of the literature was conducted to identify studies in which the central response of acupuncture in patients with musculoskeletal pain was evaluated by neuroimaging techniques. Databases searched were AMED, CINAHL, Cochrane Library, EMBASE, MEDLINE, PEDro, Pubmed, SCOPUS, SPORTDiscuss, and Web of Science...
August 2016: Journal of Acupuncture and Meridian Studies
Demao Deng, Gaoxiong Duan, Hai Liao, Yanfei Liu, Geliang Wang, Huimei Liu, Lijun Tang, Yong Pang, Jien Tao, Xin He, Wenzhao Yuan, Peng Liu
INTRODUCTION: According to the Traditional Chinese Medicine theory of acupuncture, Baihui (GV20) is applied to treat neurological and psychiatric disorders. However, the relationships between neural responses and GV20 remain unknown. Thus, the main aim of this study was to examine the brain responses induced by electro-acupuncture stimulation (EAS) at GV20. MATERIALS AND METHODS: Functional magnetic resonance imaging (fMRI) was performed in 33 healthy subjects. Based on the non-repeated event-related (NRER) paradigm, group differences were examined between GV20 and a sham acupoint using the regional homogeneity (ReHo) method...
October 2016: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
You-long Zhou, Cheng-guo Su, Shou-fang Liu, Xiang-yu Jin, Yan-li Duan, Xiao-yan Chen, Shu-hua Zhao, Quan-liang Wang, Chang-lin Dang
OBJECTIVE: To observe amplitude changes of low frequency fluctuation in brain spontaneous nervous activities induced by needling at Hand Taiyin Lung Channel, and to preliminarily explore the possible brain function network of Hand Taiyin Lung Channel. METHODS: By using functional magnetic resonance imaging (fMRI), 16 healthy volunteers underwent resting-state scanning (R1) and scanning with retained acupuncture at Hand Taiyin Lung Channel (acupuncture, AP). Data of fMRI collected were statistically calculated using amplitude of low frequency fluctuations (ALFF)...
May 2016: Chinese Journal of Integrated Traditional and Western Medicine
Demao Deng, Hai Liao, Gaoxiong Duan, Yanfei Liu, Qianchao He, Huimei Liu, Lijun Tang, Yong Pang, Jien Tao
BACKGROUND: Previous neuroimaging studies have revealed that acupuncture modulates the default mode network (DMN) in healthy subjects and patients with certain disorder. However, few studies have been performed to investigate whether or not acupuncture might modulate the DMN in patients with major depressive disorder (MDD). Thereby, the aim of the present study was to assess alterations of the DMN induced by acupuncture stimulation in patients with first-episode, drug-naïve MDD. MATERIALS AND METHODS: Twenty nine patients with first-episode, drug-naïve MDD and 29 healthy subjects were enrolled in this study...
2016: Frontiers in Human Neuroscience
Sujung Yeo, Bruce Rosen, Peggy Bosch, Maurits van den Noort, Sabina Lim
OBJECTIVE: To examine gender differences and similarities in the psychophysical and brain responses to acupuncture at GB34, a point that is frequently used to treat motor function issues in Traditional Chinese Medicine. METHODS: Functional MRI (fMRI) was used to measure brain activation in response to acupuncture at GB34 (on the right) in 19 healthy participants (9 male, 10 female). De qi sensations were rated to measure their psychophysical responses. RESULTS: Overall de qi scores did not differ by gender, although females reported greater intensity of aching (p=0...
October 2016: Acupuncture in Medicine: Journal of the British Medical Acupuncture Society
Yu Shi, Shanshan Zhang, Qiang Li, Ziping Liu, Shigui Guo, Jiangming Yang, Wen Wu
OBJECTIVE: Acupuncture is a therapeutic treatment defined as the insertion of needles into the body at specific points (i.e., acupoints). The acupuncture sensation of Deqi is an important component of acupuncture, but the functional brain responses of Deqi have not been entirely supported by the results of functional magnetic resonance imaging (fMRI) studies. The aims of this study were to test the conditions that would generate a Deqi sensation and to investigate the effect of Deqi and the response of acupuncture at different depths and intensities on brain fMRI blood oxygen level-dependent (BOLD) signals...
April 2016: Complementary Therapies in Medicine
Seok-Jae Ko, Kyungmo Park, Jieun Kim, Minji Kim, Joo-Hee Kim, Jeungchan Lee, Abdalla Z Mohamed, Inkwon Yeo, Jinsung Kim, Sun-Mi Choi, Honggeol Kim, Jae-Woo Park, Jun-Hwan Lee
BACKGROUND: Functional dyspepsia (FD) is a prevalent gastric disorder that is difficult to manage due to lack of satisfactory treatments. Acupuncture has been studied with regard to the rising need for treating FD, but the mechanism verifying its efficacy has not yet been fully revealed. The aim of this study is to explore the efficacy and mechanism of acupuncture for FD compared with a sham group. METHODS/DESIGN: We describe a proposal for a randomized, assessor-blind, sham-controlled trial with 70 eligible participants who will be randomly allocated either into an acupuncture or a sham group...
April 2, 2016: Trials
Liansheng Liu, Yuefeng Wu, Jiayi Zheng, Xinsheng Lai, Daohui Zeng, Hengguo Li, Changzheng Shi, Minjie Yang, Changhong Liang
OBJECTIVE: This study aimed to observe the cerebral activation effects of acupuncturing the Zusanli (ST36) plusYanglingquan (GB34) points in young healthy volunteers based on Regional Homogeneity (ReHo) indices. METHODS: Ten healthy volunteers were enrolled, including 4 males and 6 females between the ages 20 and 34 years with a median age of 23 years. Magnetic resonance imaging (GE Signa HDxt 3.0T) was performed in four groups: Before acupuncture (Control Group), after acupuncture at Zusanli (ST36 Group), after acupuncture at Yanglingquan (GB34 Group) and after acupuncture at both Zusanli and Yanglingquan (Compatibility Group)...
2016: Journal of X-ray Science and Technology
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