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https://www.readbyqxmd.com/read/28817684/correction-the-learning-curve-of-endoscopic-total-mastectomy-in-taiwan-a-multi-center-study
#1
Chin-Sheng Hung, Sheng-Wei Chang, Li-Min Liao, Cheng-Chiao Huang, Shih-Hsin Tu, Shou-Tung Chen, Dar-Ren Chen, Shou-Jen Kuo, Hung-Wen Lai, Ting-Mao Chou, Yao-Lung Kuo
[This corrects the article DOI: 10.1371/journal.pone.0178251.].
2017: PloS One
https://www.readbyqxmd.com/read/28817283/the-effects-of-a21g-mutation-on-transmembrane-amyloid-beta-11-40-trimer-an-in-silico-study
#2
Son Tung Ngo, Minh Tung Nguyen, Nguyen Thanh Nguyen, Van V Vu
Familial Alzheimer's disease (FAD) is passed down in family, which account for 2-3% of about 40 million AD cases worldwide. The Flemish (A21G) mutant of amyloid β (Aβ) exhibits unique properties among all hereditary mutants of FAD, including lowest aggregation rate. Recent studies showed that Aβ oligomers play key role in Alzheimer's disease (AD) pathogenesis. They could insert themselves in brain cell membrane, disrupting the membrane integrity and ion homeostasis. However, experimental studies of transmembrane Aβ oligomers have been limited due to their intrinsic heterogeneity...
August 17, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28813964/brain-computer-interface-combining-eye-saccade-two-electrode-eeg-signals-and-voice-cues-to-improve-the-maneuverability-of-wheelchair
#3
Ker-Jiun Wang, Lan Zhang, Bo Luan, Hsiao-Wei Tung, Quanfeng Liu, Jiacheng Wei, Mingui Sun, Zhi-Hong Mao
Brain-computer interfaces (BCIs) largely augment human capabilities by translating brain wave signals into feasible commands to operate external devices. However, many issues face the development of BCIs such as the low classification accuracy of brain signals and the tedious human-learning procedures. To solve these problems, we propose to use signals associated with eye saccades and blinks to control a BCI interface. By extracting existing physiological eye signals, the user does not need to adapt his/her brain waves to the device...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28811369/obesity-associated-gene-tmem18-has-a-role-in-the-central-control-of-appetite-and-body-weight-regulation
#4
Rachel Larder, M F Michelle Sim, Pawan Gulati, Robin Antrobus, Y C Loraine Tung, Debra Rimmington, Eduard Ayuso, Joseph Polex-Wolf, Brian Y H Lam, Cristina Dias, Darren W Logan, Sam Virtue, Fatima Bosch, Giles S H Yeo, Vladimir Saudek, Stephen O'Rahilly, Anthony P Coll
An intergenic region of human chromosome 2 (2p25.3) harbors genetic variants which are among those most strongly and reproducibly associated with obesity. The gene closest to these variants is TMEM18, although the molecular mechanisms mediating these effects remain entirely unknown. Tmem18 expression in the murine hypothalamic paraventricular nucleus (PVN) was altered by changes in nutritional state. Germline loss of Tmem18 in mice resulted in increased body weight, which was exacerbated by high fat diet and driven by increased food intake...
August 15, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28809463/dose-escalated-radiation-therapy-is-associated-with-better-overall-survival-in-patients-with-bone-metastases-from-solid-tumors-a-propensity-score-matched-study
#5
Yung-Chih Chou, Chien-Yu Lin, Ping-Ching Pai, Chen-Kan Tseng, Cheng-En Hsieh, Kai-Ping Chang, Cheng-Lung Hsu, Chun-Ta Liao, Chun-Chieh Wang, Shy-Chyi Chin, Tzu-Chen Yen, Tsung-Ying Ho, Ji-Hong Hong, Kin-Fong Lei, Joseph Tung-Chieh Chang, Ngan-Ming Tsang
We aimed to compare the overall survival (OS) of patients with bone metastases (BM) from solid tumors after standard-dose radiotherapy ([RT]; 30 Gy administered in 10 fractions; EQD2Gy  = 32.5 Gy) and dose-escalated RT (EQD2Gy  > 32.5 Gy). We retrospectively reviewed the clinical charts of 1795 patients (median age, 62.3 years; age range, 18-96 years) with BM from solid tumors who were referred for RT to our institute between 2000 and 2013. These patients were assigned to the standard-dose (n = 1125; 63%) and dose-escalated (n = 670; 37%) RT groups...
August 15, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28806121/social-capital-accumulation-in-location-based-mobile-game-playing-a-multiple-process-approach
#6
Hei-Tung Sung, Leif Sigerson, Cecilia Cheng
In the summer of 2016, the widespread popularization of the game Pokémon Go brought the public's attention to the possible socialization benefits associated with location-based mobile games (LBMGs), yet no studies to date have investigated this issue. LBMGs deserve greater research attention because this type of game provides a unique gaming experience that encourages players to leave their homes and navigate around their neighborhood. This distinctive feature may promote more face-to-face interactions among LBMG players...
August 2017: Cyberpsychology, Behavior and Social Networking
https://www.readbyqxmd.com/read/28800527/quantification-of-concentrated-chinese-medicine-granules-by-quantitative-polymerase-chain-reaction
#7
Yat-Tung Lo, Pang-Chui Shaw
Determination of the amount of constituent in a multi-herb product is important for quality control. In concentrated Chinese medicine granules (CCMG), no dregs are left after dissolution of the CCMG. This study is the first to examine the feasibility of using quantitative polymerase chain reaction (qPCR) to find the amount of CCMG in solution form. DNA was extracted from Hirudo and Zaocys CCMG mixed at different ratios and amplified in qPCR using species-specific primers. The threshold cycle (CT) obtained was compared with the respective standard curves...
July 31, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28798327/assessing-cell-nanoparticle-interactions-by-high-content-imaging-of-biocompatible-iron-oxide-nanoparticles-as-potential-contrast-agents-for-magnetic-resonance-imaging
#8
Roxanne Hachani, Martin A Birchall, Mark W Lowdell, Georgios Kasparis, Le D Tung, Bella B Manshian, Stefaan J Soenen, Willy Gsell, Uwe Himmelreich, Codi A Gharagouzloo, Srinivas Sridhar, Nguyen T K Thanh
Stem cell tracking in cellular therapy and regenerative medicine is an urgent need, superparamagnetic iron oxide nanoparticles (IONPs) could be used as contrast agents in magnetic resonance imaging (MRI) that allows visualization of the implanted cells ensuring they reach the desired sites in vivo. Herein, we report the study of the interaction of 3,4-dihydroxyhydrocinnamic acid (DHCA) functionalized IONPs that have desirable properties for T2 - weighted MRI, with bone marrow-derived primary human mesenchymal stem cells (hMSCs)...
August 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28797679/multiform-premature-ventricular-contractions-a-reason-not-to-ablate
#9
EDITORIAL
Roderick Tung
No abstract text is available yet for this article.
August 7, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28796581/an-analysis-of-healthy-workplace-accreditation-and-health-promotion-efforts-based-on-employees-perspectives
#10
Chen-Yin Tung, Yun-Wen Yin, Yi-Ping Zhou, Chia-Chen Chang, Pei-Ying Lin, Chia-Yun Liu
This study was conducted to analyze the effects of health promotion efforts in relation to a workplace accreditation program and differing workplace sizes. The research population for the study consisted of 966 employees working at a total of 84 different worksites located in Taipei, Taiwan. The survey instructions used were developed by the European Network for Workplace Health Promotion (WHP). The results indicated that accredited workplaces have better WHP quality than non-accredited workplaces (p<.001) and commonly implement health promotion measures related to specific health issues...
August 10, 2017: Archives of Environmental & Occupational Health
https://www.readbyqxmd.com/read/28793932/hydroxychloroquine-inhibits-cd154-expression-in-cd4-t-lymphocytes-of-systemic-lupus-erythematosus-through-nfat-but-not-stat5-signaling
#11
Shu-Fen Wu, Chia-Bin Chang, Jui-Mei Hsu, Ming-Chi Lu, Ning-Sheng Lai, Chin Li, Chien-Hsueh Tung
BACKGROUND: Overexpression of membranous CD154 in T lymphocytes has been found previously in systemic lupus erythematosus (SLE). Because hydroxychloroquine (HCQ) has been used frequently in the treatment of lupus, we sought to identify the effects of HCQ on CD154 and a possibly regulatory mechanism. METHODS: CD4(+) T cells were isolated from the blood of lupus patients. After stimulation with ionomycin or IL-15 and various concentrations of HCQ, expression of membranous CD154 and NFAT and STAT5 signaling were assessed...
August 9, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28793756/pharmacokinetics-of-rhodamine-110-and-its-organ-distribution-in-rats
#12
Shiau-Han Jiang, Yung-Yi Cheng, Teh-Ia Huo, Tung-Hu Tsai
Rhodamine dyes have been banned as food additives due to their potential tumorigenicity. Rhodamine 110 is illegal as a food additive, although its pharmacokinetics have not been characterized, and no accurate bioanalytical methods are available to quantify rhodamine 110. The aim of this study was to develop and validate a fast, stable, sensitive method to quantify rhodamine 110 using high-performance liquid chromatography coupled to tandem mass spectrometry (HPLC-MS/MS) to assess its pharmacokinetics and organ distribution in awake rats...
August 10, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28792651/regret-about-surgical-decisions-among-early-stage-breast-cancer-patients-effects-of-the-congruence-between-patients-preferred-and-actual-decision-making-roles
#13
Ashley Wei-Ting Wang, Su-Mei Chang, Cheng-Shyong Chang, Shou-Tung Chen, Dar-Ren Chen, Fang Fan, Michael H Antoni, Wen-Yau Hsu
OBJECTIVE: Early-stage breast cancer patients generally receive either a mastectomy or a lumpectomy, either by their own choice or that of their surgeon. Sometimes there is regret about the decision afterward. To better understand regret about surgical decisions, this study examined two possibilities: The first is that women who take a dominant or collaborative role in decision- making about the surgery express less regret afterward. The second is that congruence between preferred role and actual role predicts less regret...
August 9, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28792432/a-unique-3d-nitrogen-doped-carbon-composite-as-high-performance-oxygen-reduction-catalyst
#14
Ramesh Karunagaran, Tran Thanh Tung, Cameron Shearer, Diana Tran, Campbell Coghlan, Christian Doonan, Dusan Losic
The synthesis and properties of an oxygen reduction catalyst based on a unique 3-dimensional (3D) nitrogen doped (N-doped) carbon composite are described. The composite material is synthesised via a two-step hydrothermal and pyrolysis method using bio-source low-cost materials of galactose and melamine. Firstly, the use of iron salts and galactose to hydrothermally produceiron oxide (Fe₂O₃) magnetic nanoparticle clusters embedded carbon spheres. Secondly, magnetic nanoparticles diffused out of the carbon sphere when pyrolysed in the presence of melamine as nitrogen precursor...
August 9, 2017: Materials
https://www.readbyqxmd.com/read/28791595/high-resolution-melting-analysis-for-prenatal-diagnosis-of-beta-thalassemia-in-northern-thailand
#15
Pimlak Charoenkwan, Supatra Sirichotiyakul, Arunee Phusua, Sudjai Suanta, Kanda Fanhchaksai, Rattika Sae-Tung, Torpong Sanguansermsri
High-resolution melting (HRM) analysis is a rapid mutation analysis which assesses the pattern of reduction of fluorescence signal after subjecting the amplified PCR product with saturated fluorescence dye to an increasing temperature. We used HRM analysis for prenatal diagnosis of beta-thalassemia disease in northern Thailand. Five PCR-HRM protocols were used to detect point mutations in five different segments of the beta-globin gene, and one protocol to detect the 3.4 kb beta-globin deletion. We sought to characterize the mutations in carriers and to enable prenatal diagnosis in 126 couples at risk of having a fetus with beta-thalassemia disease...
August 8, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/28791302/in-vitro-laser-treatment-platform-construction-with-dental-implant-thread-surface-on-bacterial-adhesion-for-peri-implantitis
#16
Hsien-Nan Kuo, Hsiang-I Mei, Tung-Kuan Liu, Tse-Ying Liu, Lun-Jou Lo, Chun-Li Lin
This study constructs a standard in vitro laser treatment platform with dental implant thread surface on bacterial adhesion for peri-implantitis at different tooth positions. The standard clinical adult tooth jaw model was scanned to construct the digital model with 6 mm bone loss depth on behalf of serious peri-implantitis at the incisor, first premolar, and first molar. A cylindrical suite connected to the implant and each tooth root in the jaw model was designed as one experimental unit set to allow the suite to be replaced for individual bacterial adhesion...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28790344/morbidity-pattern-of-traditional-chinese-medicine-primary-care-in-the-hong-kong-population
#17
Wendy Wong, Cindy Lo Kuen Lam, Xiang Zhao Bian, Zhang Jin Zhang, Sze Tuen Ng, Shong Tung
Primary care manages >90% of illnesses requiring medical services in Hong Kong, in which 9,513 registered Chinese medicine practitioners (CMPs) provide 8.2% of the consultations. This is the first study aimed to determine the morbidity pattern in different Traditional Chinese Medicine (TCM) primary care settings in Chinese population. 55,312 patients' encounters were classified by the International Classification of Primary Care-2 (ICPC-2) from 260 of CMPs. Mean patient age was 50.5 years, with more females than males (67...
August 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28782456/a-naturally-transmitted-epitheliotropic-polyomavirus-pathogenic-in-immunodeficient-rats-characterization-transmission-and-preliminary-epidemiologic-studies
#18
Cynthia Besch-Williford, Patricia Pesavento, Shari Hamilton, Beth Bauer, Beatrix Kapusinszky, Tung Phan, Eric Delwart, Robert Livingston, Susan Cushing, Rie Watanabe, Stephen Levin, Diana Berger, Matthew Myles
We report the identification, pathogenesis, and transmission of a novel polyomavirus in severe combined immunodeficient F344 rats with null Prkdc and interleukin 2 receptor gamma genes. Infected rats experienced weight loss, decreased fecundity, and mortality. Large basophilic intranuclear inclusions were observed in epithelium of the respiratory tract, salivary and lacrimal glands, uterus, and prostate gland. Unbiased viral metagenomic sequencing of lesioned tissues identified a novel polyomavirus, provisionally named Rattus norvegicus polyomavirus 2 (RatPyV2), which clustered with Washington University (WU) polyomavirus in the Wuki clade of the Betapolyomavirus genus...
January 1, 2017: Toxicologic Pathology
https://www.readbyqxmd.com/read/28777836/measurement-of-tissue-radiation-dosage-using-a-thermal-steady-state-elastic-shear-wave
#19
Sheng-Yi Chang, Tung-Sheng Hsieh, Wei-Ru Chen, Jin-Chung Chen, Chien Chou
No abstract text is available yet for this article.
August 1, 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28777143/assessing-tumor-infiltrating-lymphocytes-in-solid-tumors-a-practical-review-for-pathologists-and-proposal-for-a-standardized-method-from-the-international-immuno-oncology-biomarkers-working-group-part-2-tils-in-melanoma-gastrointestinal-tract-carcinomas-non
#20
Shona Hendry, Roberto Salgado, Thomas Gevaert, Prudence A Russell, Tom John, Bibhusal Thapa, Michael Christie, Koen van de Vijver, M V Estrada, Paula I Gonzalez-Ericsson, Melinda Sanders, Benjamin Solomon, Cinzia Solinas, Gert G G M Van den Eynden, Yves Allory, Matthias Preusser, Johannes Hainfellner, Giancarlo Pruneri, Andrea Vingiani, Sandra Demaria, Fraser Symmans, Paolo Nuciforo, Laura Comerma, E A Thompson, Sunil Lakhani, Seong-Rim Kim, Stuart Schnitt, Cecile Colpaert, Christos Sotiriou, Stefan J Scherer, Michail Ignatiadis, Sunil Badve, Robert H Pierce, Giuseppe Viale, Nicolas Sirtaine, Frederique Penault-Llorca, Tomohagu Sugie, Susan Fineberg, Soonmyung Paik, Ashok Srinivasan, Andrea Richardson, Yihong Wang, Ewa Chmielik, Jane Brock, Douglas B Johnson, Justin Balko, Stephan Wienert, Veerle Bossuyt, Stefan Michiels, Nils Ternes, Nicole Burchardi, Stephen J Luen, Peter Savas, Frederick Klauschen, Peter H Watson, Brad H Nelson, Carmen Criscitiello, Sandra O'Toole, Denis Larsimont, Roland de Wind, Giuseppe Curigliano, Fabrice André, Magali Lacroix-Triki, Mark van de Vijver, Federico Rojo, Giuseppe Floris, Shahinaz Bedri, Joseph Sparano, David Rimm, Torsten Nielsen, Zuzana Kos, Stephen Hewitt, Baljit Singh, Gelareh Farshid, Sibylle Loibl, Kimberly H Allison, Nadine Tung, Sylvia Adams, Karen Willard-Gallo, Hugo M Horlings, Leena Gandhi, Andre Moreira, Fred Hirsch, Maria V Dieci, Maria Urbanowicz, Iva Brcic, Konstanty Korski, Fabien Gaire, Hartmut Koeppen, Amy Lo, Jennifer Giltnane, Marlon C Rebelatto, Keith E Steele, Jiping Zha, Kenneth Emancipator, Jonathan W Juco, Carsten Denkert, Jorge Reis-Filho, Sherene Loi, Stephen B Fox
Assessment of the immune response to tumors is growing in importance as the prognostic implications of this response are increasingly recognized, and as immunotherapies are evaluated and implemented in different tumor types. However, many different approaches can be used to assess and describe the immune response, which limits efforts at implementation as a routine clinical biomarker. In part 1 of this review, we have proposed a standardized methodology to assess tumor-infiltrating lymphocytes (TILs) in solid tumors, based on the International Immuno-Oncology Biomarkers Working Group guidelines for invasive breast carcinoma...
August 2, 2017: Advances in Anatomic Pathology
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