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https://www.readbyqxmd.com/read/29148391/outbreaks-of-neuroinvasive-astrovirus-associated-with-encephalomyelitis-weakness-and-paralysis-among-weaned-pigs-hungary
#1
Ákos Boros, Mihály Albert, Péter Pankovics, Hunor Bíró, Patricia A Pesavento, Tung Gia Phan, Eric Delwart, Gábor Reuter
A large, highly prolific swine farm in Hungary had a 2-year history of neurologic disease among newly weaned (25- to 35-day-old) pigs, with clinical signs of posterior paraplegia and a high mortality rate. Affected pigs that were necropsied had encephalomyelitis and neural necrosis. Porcine astrovirus type 3 was identified by reverse transcription PCR and in situ hybridization in brain and spinal cord samples in 6 animals from this farm. Among tissues tested by quantitative RT-PCR, the highest viral loads were detected in brain stem and spinal cord...
December 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29147498/reduction-rate-as-a-quantitative-knob-for-achieving-deterministic-synthesis-of-colloidal-metal-nanocrystals
#2
Tung-Han Yang, Kyle D Gilroy, Younan Xia
Despite the incredible developments made to the synthesis of colloidal metal nanocrystals, it is still challenging to produce them in a reproducible and predictable manner. This drawback can be attributed to the fact that the protocols continue to be built upon qualitative observations and empirical laws. Because of the vast number of intricately entangled experimental parameters in a synthesis, it is almost impossible to predict and control the outcome by knowingly alternating these parameters. In this Perspective article, we discuss the recent efforts in pushing nanocrystal synthesis towards a deterministic process based upon quantitative measurements...
October 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/29147117/colistin-resistance-of-pseudomonas-aeruginosa-isolated-from-snakes-in-taiwan
#3
Po-Yu Liu, Ling-Ling Weng, Shu-Ying Tseng, Chou-Chen Huang, Ching-Chang Cheng, Yan-Chiao Mao, Kwong-Chung Tung
This study included fifty-eight isolates of P. aeruginosa from the oral cavity of snakes that were recruited from clinical cases, captive and wild snakes. The minimum inhibitory concentrations (MICs) for the determination of susceptibility were identified by the broth microdilution method. Polymerase chain reaction (PCR) was employed to detect β-lactamases genes. With regard to antipseudomonal antibiotics, the lowest nonsusceptible rates were in aztreonam (15%), piperacillin/tazobactam (12%), and amikacin (9%)...
2017: Canadian Journal of Infectious Diseases & Medical Microbiology
https://www.readbyqxmd.com/read/29146147/age-induced-and-photoinduced-changes-in-gene-expression-profiles-in-facial-skin-of-caucasian-females-across-6%C3%A2-decades-of-age
#4
Alexa B Kimball, Maria B Alora-Palli, Makio Tamura, Lisa A Mullins, Chieko Soh, Robert L Binder, Neil A Houston, Emily D Conley, Joyce Y Tung, Nikki E Annunziata, Charles C Bascom, Robert J Isfort, Bradley B Jarrold, Raghu Kainkaryam, Heather L Rocchetta, Dionne D Swift, Jay P Tiesman, Kazumi Toyama, Jun Xu, Xianghong Yan, Rosemarie Osborne
BACKGROUND: Intrinsic and extrinsic factors, including ultraviolet irradiation, lead to visible signs of skin aging. OBJECTIVE: We evaluated molecular changes occurring in photoexposed and photoprotected skin of white women 20 to 74 years of age, some of whom appeared substantially younger than their chronologic age. METHODS: Histologic and transcriptomics profiling were conducted on skin biopsy samples of photoexposed (face and dorsal forearm) or photoprotected (buttocks) body sites from 158 women...
November 14, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29145422/missense-mutation-at-cldn8-associated-with-a-high-plasma-interferon-gamma-inducible-protein-10-level-in-methadone-maintained-patients-with-urine-test-positive-for-morphine
#5
Tung-Hsia Liu, Ren-Hua Chung, Sheng-Chang Wang, Chiu-Ping Fang, Hsiao-Hui Tsou, Chia-Lung Shih, Hsiang-Wei Kuo, Yun Wang, Yu-Li Liu
We previously reported a high plasma chemokine interferon gamma-inducible protein 10 (IP-10) level and prolonged electrocardiography QT-interval in methadone maintenance treatment (MMT) patients with HIV or HCV infection. The purpose of this study was to evaluate the genetic association of high plasma IP-10 level in the MMT patients. The gene-based and pathway-based association analyses were conducted using a genome-wide association study dataset in 344 MMT patients for identifying genes and pathways associated with plasma IP-10 level...
2017: PloS One
https://www.readbyqxmd.com/read/29141837/user-acceptance-of-wrist-worn-activity-trackers-among-community-dwelling-older-adults-mixed-method-study
#6
Arjun Puri, Ben Kim, Olivier Nguyen, Paul Stolee, James Tung, Joon Lee
BACKGROUND: Wearable activity trackers are newly emerging technologies with the anticipation for successfully supporting aging-in-place. Consumer-grade wearable activity trackers are increasingly ubiquitous in the market, but the attitudes toward, as well as acceptance and voluntary use of, these trackers in older population are poorly understood. OBJECTIVE: The aim of this study was to assess acceptance and usage of wearable activity trackers in Canadian community-dwelling older adults, using the potentially influential factors as identified in literature and technology acceptance model...
November 15, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29140866/one-thousand-five-hundred-fifty-nanometer-erbium-doped-nonablative-fractional-laser-for-the-treatment-of-striae-distensae-in-patients-of-skin-of-color-fitzpatrick-skin-types-iv-vi
#7
Kelly K Park, Erin Roberts, Rebecca C Tung
No abstract text is available yet for this article.
November 14, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29139202/lego-inspired-drug-design-unveiling-of-the-novel-class-of-benzo-d-thiazole-containing-a-3-4-dihydroxyphenyl-moiety-as-plasma-membrane-h-atpase-inhibitors
#8
Truong Thanh Tung, Dao Trong Tuan, Marta Grifell Junyent, Michael Palmgren, Thomas Günther-Pomorski, Anja Thoe Fuglsang, Søren Brøgger Christensen, John Nielsen
The fungal plasma membrane H+-ATPase (Pma1p) is a potential target for the discovery of new antifungal agents. Surprisingly, no structure-activity relationship studies for small molecules targeting Pma1p have been reported. Herein, we disclose a LEGO-inspired fragment assembly strategy for design, synthesis and discovery of benzo[d]thiazoles containing a 3,4-dihydroxyphenyl moiety as potential Pma1p inhibitors. A series of 2-(benzo[d]thiazol-2-ylthio)-1-(3,4-dihydroxyphenyl)ethanones was found to inhibit Pma1p with the most potent IC50 of 8 µM in an in vitro plasma membrane H+-ATPase assay...
November 15, 2017: ChemMedChem
https://www.readbyqxmd.com/read/29137150/in-vitro-fermentation-patterns-of-rice-bran-components-by-human-gut-microbiota
#9
Tung Pham, Keat Thomas Teoh, Brett J Savary, Ming-Hsuan Chen, Anna McClung, Sun-Ok Lee
Whole grain rice is a rich source of fiber, nutrients, and phytochemicals that may promote gastrointestinal health, but such beneficial components are typically removed with the bran during polishing. Soluble feruloylated arabinoxylan oligosaccharides (FAXO) and polyphenols (RBPP) isolated from rice bran are hypothesized to have positive impacts on human gut microbiota through a prebiotic function. Using an in vitro human fecal fermentation bioassay, FAXO and RBPP treatments were assessed for short-chain fatty acids (SCFA) production patterns and by evaluating their impacts on the phylogentic composition of human gut microbiota by 16S rRNA gene sequencing...
November 12, 2017: Nutrients
https://www.readbyqxmd.com/read/29136764/cardiac-apoptosis-induced-under-high-glucose-condition-involves-activation-of-igf2r-signaling-in-h9c2-cardiomyoblasts-and-streptozotocin-induced-diabetic-rat-hearts
#10
Chih-Chung Feng, Sudhir Pandey, Ching-Yuang Lin, Chia-Yao Shen, Ruey-Lin Chang, Tung-Ti Chang, Ray-Jade Chen, Vijaya Padma Viswanadha, Yueh-Min Lin, Chih-Yang Huang
The insulin-like growth factor type 2 receptor (IGF2R) overexpression has been implicated in heart disease progression. Unregulated IGF2R signaling triggers cardiac hypertrophy, apoptosis, and cardiomyopathies. The present study investigated the role of IGF2R in cardiomyocyte apoptosis under high glucose (HG) levels and in streptozotocin (STZ) induced diabetic rat hearts. We found that IGF2 and IGF2R protein expression were highly upregulated under high glucose condition in H9c2 cells as well as in STZ induced diabetic rat hearts...
November 6, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29136293/efficacy-and-safety-of-tofacitinib-for-moderate-to-severe-plaque-psoriasis-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#11
REVIEW
C-M Kuo, T-H Tung, S-H Wang, C-C Chi
The effects of tofacitinib in treating moderate-to-severe plaque psoriasis were unclear. We aimed to assess the effects of tofacitinib in treating moderate-to-severe plaque psoriasis. We searched PubMed, Cochrane Central Register of Controlled Trials, and EMBASE for relevant randomised controlled trials (RCTs), and conducted a systematic review and meta-analysis. Four RCTs with 2,724 participants were included. Compared to placebo, tofacitinib significantly improved psoriasis (≥ 75% reduction in the Psoriasis Area and Severity Index score: 5 mg BID: risk difference (RD) 0...
November 14, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29135813/pendular-seesaw-nystagmus-in-a-patient-with-a-giant-pituitary-macroadenoma-pathophysiology-and-the-role-of-the-accessory-optic-system
#12
Peter Yat-Ming Woo, Saori Takemura, Allen Ming-Yan Cheong, Alberto Chi-Ho Chu, Yung Chan, Hoi-Tung Wong, Kwong-Yau Chan
Seesaw nystagmus is characterized by cyclic eye movements with a conjugate torsional component and a dissociated vertical component. In the first half of the cycle, one eye elevates and intorts, whereas the other eye depresses and extorts. The pattern is reversed in the remaining half of the cycle. We describe a patient with a giant pituitary adenoma who developed pendular seesaw nystagmus. Disturbance in the visuovestibular system is postulated to contribute to this form of seesaw nystagmus. Lesions compressing the optic chiasm and the accessory optic system could interrupt the transmission of retinal error signals to the inferior olivary nucleus and the interstitial nucleus of Cajal, thus interfering with the adaptive mechanism of the vestibulo-ocular reflex and leading to pendular seesaw nystagmus...
November 9, 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/29134325/spatial-context-and-health-inequity-reconfiguring-race-place-and-poverty
#13
Elizabeth L Tung, Kathleen A Cagney, Monica E Peek, Marshall H Chin
Intimate connections among race, place, and poverty are increasingly featured in the health disparities literature. However, few models exist that can guide our understanding of these interconnections. We build on the Chicago School of Sociology's contributions in urban research and one of its contemporary elaborations, often described as the "neighborhood effects approach," to propose a three-axis model of health inequity. This model, in alignment with Chicago School theory, postulates a dynamic and adaptive relationship between spatial context and health inequity...
November 13, 2017: Journal of Urban Health: Bulletin of the New York Academy of Medicine
https://www.readbyqxmd.com/read/29129006/preferences-for-depression-help-seeking-among-vietnamese-american-adults
#14
Jin E Kim-Mozeleski, Janice Y Tsoh, Ginny Gildengorin, Lien H Cao, Tiffany Ho, Sarita Kohli, Hy Lam, Ching Wong, Susan Stewart, Stephen J McPhee, Tung T Nguyen
Culture impacts help-seeking preferences. We examined Vietnamese Americans' help-seeking preferences for depressive symptoms, through a telephone survey (N = 1666). A vignette describing an age- and gender-matched individual with depression was presented, and respondents chose from a list of options and provided open-ended responses about their help-seeking preferences. Results showed that 78.3% would seek professional help, either from a family doctor, a mental health provider, or both; 54.4% preferred to seek help from a family doctor but not from a mental health provider...
November 11, 2017: Community Mental Health Journal
https://www.readbyqxmd.com/read/29128846/tissue-adhesive-fk506-loaded-polymeric-nanoparticles-for-multi-layered-nano-shielding-of-pancreatic-islets-to-enhance-xenograft-survival-in-a-diabetic-mouse-model
#15
Tung Thanh Pham, Tiep Tien Nguyen, Shiva Pathak, Shobha Regmi, Hanh Thuy Nguyen, Tuan Hiep Tran, Chul Soon Yong, Jong Oh Kim, Pil-Hoon Park, Min Hui Park, Young Kyung Bae, Jeong Uk Choi, Youngro Byun, Cheol-Hee Ahn, Simmyung Yook, Jee-Heon Jeong
This study aims to develop a novel surface modification technology to prolong the survival time of pancreatic islets in a xenogenic transplantation model, using 3,4-dihydroxyphenethylamine (DOPA) conjugated poly(lactide-co-glycolide)-poly(ethylene glycol) (PLGA-PEG) nanoparticles (DOPA-NPs) carrying immunosuppressant FK506 (FK506/DOPA-NPs). The functionalized DOPA-NPs formed a versatile coating layer for antigen camouflage without interfering the viability and functionality of islets. The coating layer effectively preserved the morphology and viability of islets in a co-culture condition with xenogenic lymphocytes for 7 days...
November 1, 2017: Biomaterials
https://www.readbyqxmd.com/read/29127929/effective-degradation-of-primary-color-direct-azo-dyes-using-fe-0-aggregates-activated-persulfate-process
#16
Na Liu, Feng Ding, Chih-Huang Weng, Chi-Chin Hwang, Yao-Tung Lin
The present study examined the oxidation power of a Fe(0) aggregates/persulfate (PS/Fe(0)) system for the degradation of the wastewater containing mixed primary direct dyes (i.e., Sirius(®) Gelb S-2G, Sirius(®) Red F3B, and Sirius(®) Turkis GL01). Results indicated that decolorization efficiency was determined by operating parameters of the PS/Fe(0) system and the structural complexity of dye molecules. System efficiency increased with increasing persulfate and Fe(0) dosages. Faster decolorization was observed in experiments conducted at pH < 10...
November 8, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/29127743/three-dimensional-graphene-networks-with-abundant-sharp-edge-sites-for-efficient-electrocatalytic-hydrogen-evolution
#17
Gui Yu, Huping Wang, Xu-Bing Li, Lei Gao, Hao-Lin Wu, Jie Yang, Le Cai, Tian-Bao Ma, Chen-Ho Tung, Li-Zhu Wu
To achieve sustainable production of hydrogen (H2) through water splitting, establishing efficient and earth-abundant electrocatalysts is of great necessity. Here, we firstly reveal that morphology engineering of graphene can modulate the electronic structure of carbon skeleton and in turn endow it with excellent ability of proton reduction. Three-dimensional (3D) graphene networks with the high density of sharp edge sites are synthesized. Electrocatalytic measurements indicate that the obtained 3D graphene networks can electrocatalyze H2 evolution with an extremely low onset potential of ~18 mV in 0...
November 11, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29122956/characterization-of-age-related-penile-microvascular-hemodynamic-impairment-using-laser-speckle-contrast-imaging-possible-role-of-increased-fibrogenesis
#18
Seung-Ryeol Lee, Ki-Ho Kim, Ho-Song You, Johnny Fu, Tung-Chin Mike Hsieh, Valmik Bhargava, M Raj Rajasekaran
Current technology for penile hemodynamic evaluations in small animals is invasive and has limitations. We evaluated a novel laser speckle contrast imaging (LSCI) technique to determine age-related changes in penile microvascular perfusion (PMP) and tested the role of cavernosal muscle (CC) fibrosis mediated by Wnt-TGF β1 signaling pathways in a mouse model. Ten young (2-3 months) and old (24-28 months) wild-type C57BL6 male mice were subjected to PMP measured using a LSCI system. Penile blood flow (PBF, peak systolic velocity, PSV) was also measured using a color Doppler ultrasound for comparison...
November 2017: Physiological Reports
https://www.readbyqxmd.com/read/29122349/impact-of-brominated-amines-on-monochloramine-stability-during-in-line-and-pre-formed-chloramination-assessed-by-kinetic-modelling
#19
Sébastien Allard, Keith Cadee, Rachel Tung, Jean-Philippe Croué
In this study, a comprehensive kinetic model was developed and validated to predict the stability of monochloramine (NH2Cl) in presence of iodide and bromide for both pre-formed and in-line chloramination application in absence of organic matter. pH had the greatest influence on the stability of NH2Cl in waters containing bromide. For in-line chloramination, the NH2Cl decay over 3days was only 10% for pH9 and 58% for pH7 (400μgBr(-)/L and 3 mgCl2/L). Bromide also greatly affected the stability of NH2Cl by influencing the formation and speciation of the halamines produced during chloramination...
November 6, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29122248/effects-of-qigong-on-symptom-management-in-cancer-patients-a-systematic-review
#20
REVIEW
Dau Van Vu, Alex Molassiotis, Shirley Siu Yin Ching, Tung Thanh Le
PURPOSE: Qigong as a complementary and alternative therapy is often used by cancer patients for symptom management. The aim of this systematic review is to critically evaluate the effectiveness of Qigong on symptom management among cancer patients. METHODS: A systematic search was conducted in the following databases from their inception through May 2016: Cochrane Library, PubMed/MEDLINE, CINAHL, PsycINFO, PEDRO. All controlled clinical trials of Qigong among cancer patients were included...
November 2017: Complementary Therapies in Clinical Practice
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