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https://www.readbyqxmd.com/read/28930456/metformin-an-anthropogenic-contaminant-of-seidlitzia-rosmarinus-collected-in-a-desert-region-near-the-gulf-of-aqaba-sinai-peninsula
#1
Ahmed R Hassan, Salah M El-Kousy, Sayed A El-Toumy, Karla Frydenvang, Truong Thanh Tung, Jesper Olsen, John Nielsen, Søren Brøgger Christensen
A phytochemical investigation of Seidlitzia rosmarinus collected along the shoreline of the Gulf of Aqaba in the remote southern desert region of the Sinai peninsula has revealed the presence of the registered drug metformin (4). However, analysis of the (14)C content revealed the drug to be an anthropogenic contaminant. Consequently, natural product researchers should be aware that compounds isolated from plants might originate from environmental contamination rather than biosynthesis. The new natural product N-(4-hydroxyphenylethyl)-α-chloroferuloylamide was isolated as a mixture of the E and Z isomers along with a number of other well-established secondary metabolites...
September 20, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28929824/size-and-methylation-mosaicism-in-males-with-fragile-x-syndrome
#2
Poonnada Jiraanont, Madhur Kumar, Hiu-Tung Tang, Glenda Espinal, Paul J Hagerman, Randi J Hagerman, Nuanchan Chutabhakdikul, Flora Tassone
OBJECTIVES: Size and methylation mosaicism are a common phenomenon in Fragile X syndrome (FXS). Here, the authors report a study on twelve fragile X males with atypical mosaicism, seven of whom presented with autism spectrum disorder. METHODS: Southern Blot and PCR analysis was used for CGG allele sizing and methylation. FMR1 mRNA and FMRP expression were measured by qRT-PCR and by Homogeneous Time Resolved Fluorescence methodology respectively. RESULTS: DNA analysis showed atypical size- or methylation-mosaicism with both, full mutation and smaller (normal to premutation) alleles, as well as a combination of methylated and unmethylated alleles...
September 20, 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/28929764/decoding-the-effect-of-isobaric-substitutions-on-identifying-missing-proteins-and-variant-peptides-in-human-proteome
#3
Wai-Kok Choong, Tung-Shing Mamie Lih, Yu-Ju Chen, Ting-Yi Sung
To confirm the existence of missing proteins, we need to identify at least two unique peptides with length of 9-40 amino acids of a missing protein in bottom-up mass spectrometry-based proteomic experiments. However, an identified unique peptide of the missing protein, even identified with high level of confidence, could possibly coincide with a peptide of a commonly observed protein due to isobaric substitutions, mass modifications, alternative splice isoforms, or single amino acid variants (SAAVs). Besides unique peptides of missing proteins, identified variant peptides (SAAV-containing peptides) could also alternatively map to peptides of other proteins due to the aforementioned issues...
September 20, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28928958/exploring-vietnamese-co-authorship-patterns-in-social-sciences-with-basic-network-measures-of-2008-2017-scopus-data
#4
Tung Manh Ho, Ha Viet Nguyen, Thu-Trang Vuong, Quang-Minh Dam, Hiep-Hung Pham, Quan-Hoang Vuong
Background: Collaboration is a common occurrence among Vietnamese scientists; however, insights into Vietnamese scientific collaborations have been scarce. On the other hand, the application of social network analysis in studying science collaboration has gained much attention all over the world. The technique could be employed to explore Vietnam's scientific community. Methods: This paper employs network theory to explore characteristics of a network of 412 Vietnamese social scientists whose papers can be found indexed in the Scopus database...
2017: F1000Research
https://www.readbyqxmd.com/read/28928442/genome-wide-association-and-hla-region-fine-mapping-studies-identify-susceptibility-loci-for-multiple-common-infections
#5
Chao Tian, Bethann S Hromatka, Amy K Kiefer, Nicholas Eriksson, Suzanne M Noble, Joyce Y Tung, David A Hinds
Infectious diseases have a profound impact on our health and many studies suggest that host genetics play a major role in the pathogenesis of most of them. We perform 23 genome-wide association studies for common infections and infection-associated procedures, including chickenpox, shingles, cold sores, mononucleosis, mumps, hepatitis B, plantar warts, positive tuberculosis test results, strep throat, scarlet fever, pneumonia, bacterial meningitis, yeast infections, urinary tract infections, tonsillectomy, childhood ear infections, myringotomy, measles, hepatitis A, rheumatic fever, common colds, rubella and chronic sinus infection, in over 200,000 individuals of European ancestry...
September 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/28928402/core-shell-heterostructured-multiwalled-carbon-nanotubes-reduced-graphene-oxide-nanoribbons-chitosan-a-robust-nanobiocomposite-for-enzymatic-biosensing-of-hydrogen-peroxide-and-nitrite
#6
Veerappan Mani, Mani Govindasamy, Shen-Ming Chen, Tse-Wei Chen, Annamalai Senthil Kumar, Sheng-Tung Huang
A robust nanobiocomposite based on core-shell heterostructured multiwalled carbon nanotubes@reduced graphene oxide nanoribbons (MWCNTs@rGONRs)/chitosan (CHIT) was described for the fabrication of sensitive, selective, reproducible and durable biosensor for hydrogen peroxide (H2O2) and nitrite (NO2(-)). The excellent physicochemical properties of MWCNTs@rGONRs such as, presence of abundant oxygen functionalities, higher area-normalized edge-plane structures and chemically active sites in combination with excellent biocompatibility of CHIT resulting in the versatile immobilization matrix for myoglobin (Mb)...
September 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28925691/core-shell-mn7%C3%A2-mn-cd-12-assembled-from-core-mn7-disc
#7
Ling-Yu Guo, Hai-Feng Su, Mohamedally Kurmoo, Chen-Ho Tung, Di Sun, Lan-Sun Zheng
Post-synthetic decoration of the Mn7, {MnIII⊆MnII6}, core with CdII in the outer shell to form the next generation Mn13Cd6, {MnIII⊆MnIII3MnII3⊆ MnII6CdII6}, core-shell disc was achieved and confirmed by single-crystal X-ray diffraction. The formation of Mn13Cd6 has only been successful with Cd2+ and if the Cd salt is added within the first half hour window when the inner Mn7 has formed. EDX and ICP-AES gave the accurate content and confirm the average found by X-ray diffraction. HR-ESI-MS was even more precise by revealing three prominent molecular species, Mn13Cd6, Mn14Cd5 and Mn15Cd4, having a distribution of metals...
September 19, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28924370/kaempferol-inhibits-the-invasion-and-migration-of-renal-cancer-cells-through-the-downregulation-of-akt-and-fak-pathways
#8
Tung-Wei Hung, Pei-Ni Chen, Hsu-Chen Wu, Sheng-Wen Wu, Pao-Yu Tsai, Yih-Shou Hsieh, Horng-Rong Chang
Kaempferol, which is isolated from several natural plants, is a polyphenol belonging to the subgroup of flavonoids. Kaempferol exhibits various pharmacological activities, including anti-inflammatory, antioxidant, antimicrobial, and anticancer activities. In this study, kaempferol can significantly inhibit the invasion and migration of 786-O renal cell carcinoma (RCC) without cytotoxicity. We examined the potential mechanisms underlying its anti-invasive activities on 786-O RCC cells. Western blot was performed, and the results showed that kaempferol attenuates the manifestation of metalloproteinase-2 (MMP-2) protein and activity...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28924237/structural-transformation-of-biochar-black-carbon-by-c60-superstructure-environmental-implications
#9
Minori Uchimiya, Joseph J Pignatello, Jason C White, Szu-Tung Hu, Paulo J Ferreira
Pyrogenic carbon is widespread in soil due to wildfires, soot deposition, and intentional amendment of pyrolyzed waste biomass (biochar). Interactions between engineered carbon nanoparticles and natural pyrogenic carbon (char) are unknown. This study first employed transmission electron microscopy (TEM) and X-ray diffraction (XRD) to interpret the superstructure composing aqueous fullerene C60 nanoparticles prepared by prolonged stirring of commercial fullerite in water (nC60-stir). The nC60-stir was a superstructure composed of face-centered cubic (fcc) close-packing of near-spherical C60 superatoms...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28923596/chemically-activated-luminopsins-allow-optogenetic-inhibition-of-distributed-nodes-in-an-epileptic-network-for-non-invasive-and-multi-site-suppression-of-seizure-activity
#10
Jack K Tung, Fu Hung Shiu, Kevin Ding, Robert E Gross
Although optogenetic techniques have proven to be invaluable for manipulating and understanding complex neural dynamics over the past decade, they still face practical and translational challenges in targeting networks involving multiple, large, or difficult-to-illuminate areas of the brain. We utilized inhibitory luminopsins to simultaneously inhibit multiple limbic structures of the rat brain in a hardware-independent and cell-type specific manner to suppress seizure activity in a rat model of epilepsy. In addition to elucidating mechanisms of seizure suppression never directly demonstrated before, this work also illustrates how precise multi-focal control of pathological circuits can be advantageous for the treatment of epilepsy, which may also be applicable to the treatment and understanding of other neurological disorders involving broad neural circuits...
September 15, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28923540/the-contribution-of-admixture-to-primate-evolution
#11
REVIEW
Jenny Tung, Luis B Barreiro
Genome-wide data on genetic variation are now available for multiple primate species and populations, facilitating analyses of evolutionary history within and across taxa. One emerging theme from these studies involves the central role of admixture. Genomic data sets indicate that both ancient gene flow following initial taxonomic divergence and ongoing gene flow at current species boundaries are common. These findings are of particular interest given evidence for a complex history of admixture in our own lineage, including examples of ecologically driven adaptive introgression...
September 15, 2017: Current Opinion in Genetics & Development
https://www.readbyqxmd.com/read/28923309/altered-penile-caveolin-expression-in-diabetes-potential-role-in-erectile-dysfunction
#12
Jay Parikh, Alice Zemljic-Harpf, Johnny Fu, Dimosthenis Giamouridis, Tung-Chin Hsieh, Adam Kassan, Karnam S Murthy, Valmik Bhargava, Hemal H Patel, M Raj Rajasekaran
BACKGROUND: The pathophysiology of increased severity of erectile dysfunction in men with diabetes and their poor response to oral pharmacotherapy are unclear. Defective vascular endothelium and consequent impairment in the formation and action of nitric oxide (NO) are implicated as potential mechanisms. Endothelial NO synthase, critical for NO generation, is localized to caveolae, plasma membrane lipid rafts enriched in structural proteins, and caveolins. Type 2 diabetes mellitus (T2DM)-induced changes in caveolin expression are recognized to play a role in cardiovascular dysfunction...
September 8, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28922734/persistent-antidepressant-effect-of-low-dose-ketamine-and-activation-in-the-supplementary-motor-area-and-anterior-cingulate-cortex-in-treatment-resistant-depression-a-randomized-control-study
#13
Mu-Hong Chen, Cheng-Ta Li, Wei-Chen Lin, Chen-Jee Hong, Pei-Chi Tu, Ya-Mei Bai, Chih-Ming Cheng, Tung-Ping Su
A single low-dose ketamine infusion exhibited a rapid antidepressant effect within 1h. Despite its short biological half-life (approximately 3h), the antidepressant effect of ketamine has been demonstrated to persist for several days. However, changes in brain function responsible for the persistent antidepressant effect of a single low-dose ketamine infusion remain unclear METHODS: Twenty-four patients with treatment-resistant depression (TRD) were randomized into three groups according to the treatment received: 0...
September 9, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28922251/shank3-regulates-intestinal-barrier-function-through-modulating-zo-1-expression-through-the-pkc%C3%AE%C2%B5-dependent-pathway
#14
Shu-Chen Wei, Hsin-Fang Yang-Yen, Po-Nien Tsao, Meng-Tzu Weng, Chien-Chih Tung, Linda C H Yu, Liang-Chuan Lai, Jen-Hao Hsiao, Eric Y Chuang, Chia-Tung Shun, Yen-Hsuan Ni, Ramnik J Xavier, Daniel K Podolsky, Jeffery J Y Yen, Jau-Min Wong
BACKGROUND: The integrity of the gut barrier in patients with inflammatory bowel disease is known to be impaired but the exact mechanisms remain mostly unknown. SHANK3 mutations are associated with autism, and patients with autism are known to have higher proportions of inflammatory bowel disease. Here, we explore the role of SHANK3 in inflammatory bowel disease, both in vivo and in vitro. METHODS: Dextran sulfate sodium colitis was induced in SHANK3 knockout mice...
August 23, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28922124/improving-the-capacity-of-molecular-communication-using-enzymatic-reaction-cycles
#15
Hamdan Awan, Chun Tung Chou
This paper considers the capacity of a diffusion-based molecular communication link assuming the receiver uses chemical reactions. The key contribution is we show that enzymatic reaction cycles, which is a class of chemical reactions commonly found in cells consisting of a forward and a backward enzymatic reaction, can improve the capacity of the communication link. The technical difficulty in analysing enzymatic reaction cycles is that their reaction rates are nonlinear. We deal with this by assuming that the amount of certain chemicals in the enzymatic reaction cycle is large...
September 18, 2017: IEEE Transactions on Nanobioscience
https://www.readbyqxmd.com/read/28920414/metagenomic-analysis-of-bacterial-community-structure-and-diversity-of-lignocellulolytic-bacteria-in-vietnamese-native-goat-rumen
#16
Huyen Thi Do, Khoa Trong Dao, Viet Khanh Hoang Nguyen, Giang Ngoc Le, Phuong Thi Mai Nguyen, Lam Tung Le, Nguyet Thu Phung, Nico van Straalen, Dick Roelofs, Hai Nam Truong
Objective: In a previous study, analysis of Illumina sequenced metagenomic DNA data of bacteria in Vietnamese goats' rumen showed a high diversity of putative lignocellulolytic genes. In this study, taxonomy speculation of microbial community and lignocellulolytic bacteria population in the rumen was conducted to elucidate a role of bacterial structure for effective degradation of plant materials. Methods: The metagenomic data had been subjected into Basic Local Alignment Search Tool (BLASTX) algorithm and the National Center for Biotechnology Information (NCBI) non-redundant (NR) sequence database...
September 18, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28918909/progesterone-analogues-reduce-plasma-epstein-barr-virus-dna-load-and-improve-pain-control-in-recurrent-metastatic-nasopharyngeal-carcinoma-patients-under-supportive-care
#17
Chia-Yen Hung, Tung-Liang Lin, Yung-Chia Kuo, Chia-Hsun Hsieh, Hung-Ming Wang, Cheng-Lung Hsu
BACKGROUND: Progesterone analogues, such as megestrol acetate (MA) and medroxyprogesterone (MPA), have been used for the palliative care of cancer cachexia for decades and have proven to increase body weight and improve quality of life and performance status. The objective of this study was to determine the effect of progesterone analogue use on quality of life in terms of pain control, performance status, body weight gain, and Epstein-Barr virus (EBV) DNA load in recurrent/metastatic nasopharyngeal carcinoma (NPC) patients...
August 2017: Biomedical Journal
https://www.readbyqxmd.com/read/28916962/effects-of-cholecystectomy-on-recurrent-biliary-complications-after-endoscopic-treatment-of-common-bile-duct-stone-a-population-based-cohort-study
#18
Chi-Tung Cheng, Chun-Nan Yeh, Kun-Chun Chiang, Ta-Sen Yeh, Kuan-Fu Chen, Shao-Wei Chen
BACKGROUND: The aim of this study was to evaluate the benefits of cholecystectomy on mitigating recurrent biliary complications following endoscopic treatment of common bile duct stone. METHODS: We used the data from the Taiwan National Health Insurance Research Database to conduct a population-based cohort study. Among 925 patients who received endoscopic treatment for choledocholithiasis at the first admission from 2005 to 2012, 422 received subsequent cholecystectomy and 503 had gallbladder (GB) left in situ...
September 15, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28915165/employee-organizational-commitment-and-hospital-performance
#19
Kevin M Baird, Amy Tung, Yanjie Yu
BACKGROUND: There is widespread evidence of the purported benefits of employee organizational commitment (EOC) and its impact on both individual and organizational performance. This study contributes to this literature by providing a unique insight into this relationship, focusing on the interrelationship between EOC with hospital performance and the role of the provision of adequate facilities in eliciting EOC. PURPOSE: The aim of this study was to introduce and empirically examine a new theoretical model in which it is argued that the performance of hospitals with regard to the provision of adequate facilities (medical facilities, support facilities, and staff resources) influences the level of EOC, which in turn influences hospital performance with regard to patient care and operational effectiveness...
September 15, 2017: Health Care Management Review
https://www.readbyqxmd.com/read/28912553/polarization-independent-wide-incident-angle-and-dual-band-perfect-absorption-based-on-near-field-coupling-in-a-symmetric-metamaterial
#20
Bui Son Tung, Bui Xuan Khuyen, Young Ju Kim, Vu Dinh Lam, Ki Won Kim, YoungPak Lee
We numerically and experimentally investigated a dual-band metamaterial perfect absorber (MPA), utilizing the near-field coupling of double split-ring resonators (DSRRs). Owing to the near-field coupling between resonators, two arms in each DSRR resonate in different phases, leading to a dual-band perfect absorption. The proposed MPA also exhibits polarization-insensitive behavior and maintains the high absorption above 90% up to a wide range of incident angle more than 45°. Finally, to further consolidate our approach, a multi-band absorption is also studied by exploiting the near-field coupling among a larger number of DSRRs...
September 14, 2017: Scientific Reports
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