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https://www.readbyqxmd.com/read/28333014/single-nucleotide-polymorphism-tgf%C3%AE-1-r25p-correlates-with-acute-toxicity-during-neoadjuvant-chemoradiotherapy-in-rectal-cancer-patients
#1
J Joshua Smith, Isaac Wasserman, Sarah A Milgrom, Oliver S Chow, Chin-Tung Chen, Sujata Patil, Karyn A Goodman, Julio Garcia-Aguilar
PURPOSE: To validate the finding of an association between single nucleotide polymorphisms (SNPs) and toxicity during chemoradiotherapy (CRT) in rectal cancer patients, in an independent population. METHODS AND MATERIALS: The cohort consisted of 165 patients who received CRT for rectal cancer from 2006 to 2012. Prospectively recorded toxicity information, graded according to the Common Terminology Criteria for Adverse Events version 3.0, was retrieved from the medical record...
April 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28332554/fucoidan-induces-toll-like-receptor-4-regulated-reactive-oxygen-species-and-promotes-endoplasmic-reticulum-stress-mediated-apoptosis-in-lung-cancer
#2
Hsien-Yeh Hsu, Tung-Yi Lin, Mei-Kuang Lu, Pei-Ju Leng, Shu-Ming Tsao, Yu-Chung Wu
Fucoidan, a sulfated polysaccharide extracted from brown algae, exhibits anti-cancer activity. However, the effects and mechanism of fucoidan-induced apoptosis via endoplasmic reticulum (ER) stress is unclear. In this study, we demonstrated that fucoidan prevents tumorigenesis and reduces tumor size in LLC1-xenograft male C57BL/6 mice. Fucoidan induces an ER stress response by activating the PERK-ATF4-CHOP pathway, resulting in apoptotic cell death in vitro and in vivo. Furthermore, ATF4 knockdown abolishes fucoidan-induced CHOP expression and rescues cell viability...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28331798/aspirin-and-risk-of-multiple-myeloma-in-adults-a-systematic-review-and-meta-analysis
#3
REVIEW
Shing Fung Lee, Ting Ying Ng, Frank Chi Sing Wong, Stewart Yuk Tung
Multiple myeloma is a relatively uncommon plasma cell malignancy. Preclinical and clinical studies have suggested that aspirin might modify the risk of multiple myeloma. We performed a systematic review and meta-analysis of studies to examine the association between regular aspirin use and risk of multiple myeloma. Five observational studies including 332,660 adults were evaluated. The pooled estimate had a hazard ratio of 0.90 (95% confidence interval =0.58-1.39; P=0.638). Odds ratios from the two case-control studies were similar...
2017: Leukemia Research Reports
https://www.readbyqxmd.com/read/28331772/an-automated-gravity-driven-csf-drainage-system-decreases-complications-and-lowers-costs
#4
Robert E Lieberson, Jan Eckermann, William Meyer, Tung Trang
BACKGROUND: FlowSafe(TM) (BeckerSmith Medical, Irvine, CA, USA) is a novel, robotic, external lumbar drainage (ELD) system, which was designed to control cerebrospinal fluid (CSF) drainage, reduce complications, and decrease treatment costs. METHODS:  Forty-seven consecutive neurosurgical patients requiring ELD were treated using the FlowSafe system. RESULTS: In 39 of 40 patients with traumatic and surgical dural openings, potential CSF leaks were avoided...
February 3, 2017: Curēus
https://www.readbyqxmd.com/read/28330586/structured-wii-protocol-for-rehabilitation-of-shoulder-impingement-syndrome-a-pilot-study
#5
John-Ross Rizzo, Peter Thai, Edward J Li, Terence Tung, Todd E Hudson, Joseph Herrera, Preeti Raghavan
OBJECTIVE: To determine the feasibility and efficacy of using a structured Nintendo Wii protocol to improve range of motion, strength, and quality of life in patients with shoulder impingement syndrome. METHODS: A total of 14 patients with shoulder pain were randomized to perform a structured Wii protocol (n=8) or conventional therapy (n=6). Pain-free shoulder range of motion, strength, shoulder pain and disability, and quality of life were assessed pre- and post-treatment...
March 15, 2017: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28327658/miniaturization-for-ultrathin-metamaterial-perfect-absorber-in-the-vhf-band
#6
Bui Xuan Khuyen, Bui Son Tung, Young Joon Yoo, Young Ju Kim, Ki Won Kim, Liang-Yao Chen, Vu Dinh Lam, YoungPak Lee
An efficient resolution for ultrathin metamaterial perfect absorber (MPA) is proposed and demonstrated in the VHF radio band (30-300 MHz). By adjusting the lumped capacitors and the through vertical interconnects, the absorber is miniaturized to be only λ/816 and λ/84 for its thickness and periodicity with respect to the operating wavelength (at 102 MHz), respectively. The detailed simulation and calculation show that the MPA can maintain an absorption rate over 90% in a certain range of incident angle and with a wide variation of capacitance...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28326629/solvent-controlled-phase-transition-of-a-co-ii-organic-framework-from-achiral-to-chiral-and-two-to-three-dimen-sion
#7
Xing-Po Wang, Wen-Miao Chen, Xiao-Yu Li, Cyril Rajnák, Zhen-Yu Feng, Mohamedally Kurmoo, Roman Boča, Chunjiang Jia, Chen-Ho Tung, Di Sun
We report an unprecedented reversible dynamic transformation in a metal-organic framework involving bond formation that is accompanied by two important structural changes, achiral to chiral and two- to three-dimension. Using two bent organic lig-ands (diimpym = 4,6-di(1H-imidazol-1-yl)pyrimidine; H2npta = 5-nitroisophthalic acid) and CoII(NO3)2*6H2O the coordination pol-ymer Co(diimpym)(npta)*CH3OH, 1*CH3OH, was obtained sol-vothermally. Its structure consisting of knitted pairs of square layers (44-sql) of five-coordinated Co, disordered methanol and crystallizing in achiral Pbca space group at room temperature undergoes a single-crystal to single-crystal (SC-SC) transfor-mation to a 3D interpenetrated framework (pcu) of six-coordinated Co and ordered methanol in chiral P212121 space group below 220 K...
March 21, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28323854/the-unfinished-health-agenda-neonatal-mortality-in-cambodia
#8
Rathmony Hong, Pauline Yongeun Ahn, Frank Wieringa, Tung Rathavy, Ludovic Gauthier, Rathavuth Hong, Arnaud Laillou, Judit Van Geystelen, Jacques Berger, Etienne Poirot
BACKGROUND: Reduction of neonatal and under-five mortality rates remains a primary target in the achievement of universal health goals, as evident in renewed investments of Sustainable Development Goals. Various studies attribute declines in mortality to the combined effects of improvements in health care practices and changes in socio-economic factors. Since the early nineties, Cambodia has managed to evolve from a country devastated by war to a nation soon to enter the group of middle income countries...
2017: PloS One
https://www.readbyqxmd.com/read/28323416/one-pot-two-nanoprobe-assay-uncovers-targeted-glycoprotein-biosignature
#9
Mira Anne C Dela Rosa, Wei-Chun Chen, Yi-Ju Chen, Rofeamor P Obena, Chih-Hsiang Chang, Rey Y Capangpangan, Tung-Hung Su, Chi-Ling Chen, Pei-Jer Chen, Yu-Ju Chen
We report a one-pot two-nanoprobe approach coupled to mass spectrometry for simultaneous quantification and post-translational modification (PTM) profiling of targeted protein in biofluid. Using N-glycoprotein as model, the assay employs two nanoprobes, antibody-conjugated SiO2 nanoparticles and lectin-conjugated magnetic Fe3O4 nanoparticles, to achieve target glycoprotein isolation from biofluid and subsequent glycopeptide enrichment in a single tube. As demonstrated on α-fetoprotein (AFP), a serum biomarker for hepatocellular carcinoma (HCC), the assay has high purification specificity (20 glycopeptides) with 2-fold and 10-fold superior total glycopeptide intensity compared to non-one-pot method (9 glycopeptides) or without enrichment (6 glycopeptides), respectively...
March 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28322295/alterations-in-gastric-microbiota-after-h-pylori-eradication-and-in-different-histological-stages-of-gastric-carcinogenesis
#10
Tung Hiu Li, Youwen Qin, Pak Chung Sham, K S Lau, Kent-Man Chu, Wai K Leung
The role of bacteria other than Helicobacter pylori (HP) in the stomach remains elusive. We characterized the gastric microbiota in individuals with different histological stages of gastric carcinogenesis and after receiving HP eradication therapy. Endoscopic gastric biopsies were obtained from subjects with HP gastritis, gastric intestinal metaplasia (IM), gastric cancer (GC) and HP negative controls. Gastric microbiota was characterized by Illumina MiSeq platform targeting the 16 S rDNA. Apart from dominant H...
March 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28306623/risk-of-epilepsy-in-individuals-with-posttraumatic-stress-disorder-a-nationwide-longitudinal-study
#11
Yu-Hsiung Chen, Han-Ting Wei, Ya-Mei Bai, Ju-Wei Hsu, Kai-Lin Huang, Tung-Ping Su, Cheng-Ta Li, Wei-Chen Lin, Yi-Hui Wu, Tai-Long Pan, Tzeng-Ji Chen, Shih-Jen Tsai, Mu-Hong Chen
OBJECTIVE: Several cross-sectional studies reported a relationship between post-traumatic stress disorder (PTSD) and epilepsy. However, the temporal association between PTSD and epilepsy has rarely been investigated. We hypothesized that the risk of developing epilepsy later in life would be higher in patients with PTSD than in those without PTSD. METHODS: Using the Taiwan National Health Insurance Research Database, 6425 individuals with PTSD and 24,980 age-/sex-matched controls were enrolled between 2002 and 2009 in our study, and followed up to the end of 2011...
March 17, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28303931/the-development-of-novel-lta4h-modulators-to-selectively-target-ltb4-generation
#12
Caroline M Low, Samia Akthar, Dhiren F Patel, Stephan Löser, Chi-Tung Wong, Patricia L Jackson, J Edwin Blalock, Stephen A Hare, Clare M Lloyd, Robert J Snelgrove
The pro-inflammatory mediator leukotriene B4 (LTB4) is implicated in the pathologies of an array of diseases and thus represents an attractive therapeutic target. The enzyme leukotriene A4 hydrolase (LTA4H) catalyses the distal step in LTB4 synthesis and hence inhibitors of this enzyme have been actively pursued. Despite potent LTA4H inhibitors entering clinical trials all have failed to show efficacy. We recently identified a secondary anti-inflammatory role for LTA4H in degrading the neutrophil chemoattractant Pro-Gly-Pro (PGP) and rationalized that the failure of conventional LTA4H inhibitors may be that they inadvertently prevented PGP degradation...
March 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28302478/molecular-mechanisms-of-discrotophos-induced-toxicity-in-hepg2-cells-the-role-of-csa-in-oxidative-stress
#13
You-Cheng Hseu, Tung-Wei Hsu, Heng-Dao Lin, Chin Hui Chen, Ssu Ching Chen
Dicrotophos (Dic), an insecticide and acaricide, is used against a variety of sucking, boring and chewing pests. It was proven that Dic induced oxidative DNA damage in HepG2 cells. However, the molecular mechanisms of this compound were still unclear. First of all, the cytotoxicity and oxidative DNA damage were confirmed. Next, using RNA-seq for detecting differential expressed genes (DEGs) in cells treated with 50 μM Dic for 24 h, we showed that the dysregulation of these genes, irrespective of up (1298 genes) or down (2125 genes) regulation, could be attributed to some diverse pathways/metabolisms using KEGG analysis, particularly in DNA damage responses (DDRs) such as oxidative phosphorylation, nucleotide excision repair and cell cycle arrest...
March 14, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28301136/broadband-omnidirectional-light-trapping-in-gold-decorated-zno-nanopillar-arrays
#14
Yuan-Ming Chang, Man-Ling Lin, Tung-Yen Lai, Chang-Hung Chen, Hsin-Yi Lee, Chih-Ming Lin, YewChung Sermon Wu, Yen-Fu Lin, Jenh-Yih Juang
The Photoluminescence (PL) and reflectivity characteristics of zinc oxide nanopillars (ZnO-NPs) grown on indium-tin-oxide (ITO)-coated glasses were investigated. The room temperature PL showed bright white-light emission for the undoped ZnO-NPs grown at 600 °C, suggesting the close relation between the optical characteristic and the growth conditions being carried out for obtaining the present ZnO-NPs. The reflectivity of the as-grown ZnO-NPs array was about ~29 % with the wavelength of the incident light ranging from 200-1800 nm...
March 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28300660/mechanistic-understanding-of-the-cysteine-capping-modifications-of-antibodies-enables-selective-chemical-engineering-in-live-mammalian-cells
#15
Xiaotian Zhong, Tao He, Amar S Prashad, Wenge Wang, Justin Cohen, Darren Ferguson, Amy S Tam, Eric Sousa, Laura Lin, Lioudmila Tchistiakova, Scott Gatto, Aaron D'Antona, Yen-Tung Luan, Weijun Ma, Richard Zollner, Jing Zhou, Bo Arve, Will Somers, Ronald Kriz
Protein modifications by intricate cellular machineries often redesign the structure and function of existing proteins to impact biological networks. Disulfide bond formation between cysteine (Cys) pairs is one of the most common modifications found in extracellularly-destined proteins, key to maintaining protein structure. Unpaired surface cysteines on secreted mammalian proteins are also frequently found disulfide-bonded with free Cys or glutathione (GSH) in circulation or culture, the mechanism for which remains unknown...
March 11, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28298628/the-size-of-spontaneous-pneumothorax-is-a-predictor-of-unsuccessful-catheter-drainage
#16
Tung-Ming Tsai, Mong-Wei Lin, Yao-Jen Li, Chin-Hao Chang, Hsien-Chi Liao, Chao-Yu Liu, Hsao-Hsun Hsu, Jin-Shing Chen
Small-bore thoracic catheter drainage is recommended for a first large or symptomatic episode of primary spontaneous pneumothorax (PSP). However, one-third of these patients require a second procedure because of treatment failure. We investigated the factors associated with unsuccessful pigtail catheter drainage in the management of PSP. In this retrospective study, using a prospectively collected database, we enrolled 253 consecutive patients with PSP who underwent pigtail catheter drainage as initial treatment, from December 2006 to June 2011...
March 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28297938/extracting-trajectory-equations-of-classical-periodic-orbits-from-the-quantum-eigenmodes-in-two-dimensional-integrable-billiards
#17
Y H Hsieh, Y T Yu, P H Tuan, J C Tung, K F Huang, Y F Chen
The trajectory equations for classical periodic orbits in the equilateral-triangular and circular billiards are systematically extracted from quantum stationary coherent states. The relationship between the phase factors of quantum stationary coherent states and the initial positions of classical periodic orbits is analytically derived. In addition, the stationary coherent states with noncoprime parametric numbers are shown to correspond to the multiple periodic orbits, which cannot be explicable in the one-particle picture...
February 2017: Physical Review. E
https://www.readbyqxmd.com/read/28297660/progesterone-prevents-high-grade-serous-ovarian-cancer-by-inducing-necroptosis-of-p53-defective-fallopian-tube-epithelial-cells
#18
Na-Yiyuan Wu, Hsuan-Shun Huang, Tung Hui Chao, Hsien Ming Chou, Chao Fang, Chong-Zhen Qin, Chueh-Yu Lin, Tang-Yuan Chu, Hong Hao Zhou
High-grade serous ovarian carcinoma (HGSOC) originates mainly from the fallopian tube (FT) epithelium and always carries early TP53 mutations. We previously reported that tumors initiate in the FT fimbria epithelium because of apoptotic failure and the expansion of cells with DNA double-strand breaks (DSB) caused by bathing of the FT epithelial cells in reactive oxygen species (ROSs) and hemoglobin-rich follicular fluid (FF) after ovulation. Because ovulation is frequent and HGSOC is rare, we hypothesized that luteal-phase progesterone (P4) could eliminate p53-defective FT cells...
March 14, 2017: Cell Reports
https://www.readbyqxmd.com/read/28297352/improved-setup-and-positioning-accuracy-using-a-three-point-customized-cushion-mask-bite-block-immobilization-system-for-stereotactic-reirradiation-of-head-and-neck-cancer
#19
He Wang, Congjun Wang, Samuel Tung, Andrew Wilson Dimmitt, Pei Fong Wong, Mark A Edson, Adam S Garden, David I Rosenthal, Clifton D Fuller, Gary B Gunn, Vinita Takiar, Xin A Wang, Dershan Luo, James N Yang, Jennifer Wong, Jack Phan
The purpose of this study was to investigate the setup and positioning uncertainty of a custom cushion/mask/bite-block (CMB) immobilization system and determine PTV margin for image-guided head and neck stereotactic ablative radiotherapy (HN-SABR). We analyzed 105 treatment sessions among 21 patients treated with HN-SABR for recurrent head and neck cancers using a custom CMB immobilization system. Initial patient setup was performed using the ExacTrac infrared (IR) tracking system and initial setup errors were based on comparison of ExacTrac IR tracking system to corrected online ExacTrac X-rays images registered to treatment plans...
May 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28295752/synthesis-of-an-%C3%AE-2%C3%A2-8-s-linked-gd3-antigen-and-evaluation-of-the-immunogenicity-of-its-glycoconjugate
#20
Chun-Cheng Lin, Ting-Chun Kuan, Hsin-Ru Wu, Avijit K Adak, Ben-Yuan Li, Chien-Fu Liang, Shih-Pin Chiou, Jung-Tung Hung Hung, Alice L Yu Yu, Jih Ru Hwu
Replacing the interglycosidic oxygen atom with a nonhydrolyzable sulfur atom has attracted significant interest because it provides opportunities for developing new glycoconjugate vaccines. Herein, a stereocontrolled and highly convergent method for synthesizing a non-reducing end, inter-S-glycosidic variant of the GD3 (α(2→8)-S-linked GD3) antigen, capable of being resistant to enzymatic hydrolysis was reported. The key steps in the synthesis involved a regio- and stereoselective α(2→3) sialylation of a lactoside acceptor with a C8-iodide-derivatized sialyl donor, followed by an anomeric S-alkylation, which enabled the construction of a terminal S-linked α(2→8) disialyl residue in a stereoselective manner...
March 12, 2017: Chemistry: a European Journal
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