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https://www.readbyqxmd.com/read/28432932/surveillance-of-vittaforma-corneae-in-hot-springs-by-a-small-volume-procedure
#1
Jung-Sheng Chen, Tsui-Kang Hsu, Bing-Mu Hsu, Tung-Yi Huang, Yu-Li Huang, Men-Fang Shaio, Dar-Der Ji
Vittaforma corneae is an obligate intracellular fungus and can cause human ocular microsporidiosis. Although accumulating reports of V. corneae causing keratoconjunctivitis in both healthy and immunocompromised persons have been published, little is known about the organism's occurrence in aquatic environments. Limitations in detection sensitivity have meant a large sampling volume is required to detect the pathogen up to now, which is problematic. A recent study in Taiwan has shown that some individuals suffering from microsporidial keratitis (MK) were infected after exposure to the pathogen at a hot spring...
April 19, 2017: Water Research
https://www.readbyqxmd.com/read/28431509/regular-recreational-physical-activity-and-risk-of-head-and-neck-cancer
#2
Chen-Lin Lin, Wei-Ting Lee, Chun-Yen Ou, Jenn-Ren Hsiao, Cheng-Chih Huang, Jehn-Shyun Huang, Tung-Yiu Wong, Ken-Chung Chen, Sen-Tien Tsai, Sheen-Yie Fang, Tze-Ta Huang, Jiunn-Liang Wu, Yuan-Hua Wu, Wei-Ting Hsueh, Chia-Jui Yen, Yu-Hsuan Lai, Hsiao-Chen Liao, Shang-Yin Wu, Ming-Wei Yang, Forn-Chia Lin, Jang-Yang Chang, Yi-Hui Wang, Ya-Ling Weng, Han-Chien Yang, Yu-Shan Chen, Jeffrey S Chang
BACKGROUND: Although substantial evidence supports a 20-30% risk reduction of colon cancer, breast cancer, and endometrial cancer by physical activity (PA), the evidence for head and neck cancer (HNC) is limited. Three published studies on the association between PA and HNC have generated inconsistent results. The current study examined the association between recreational PA (RPA) and HNC risk with a more detailed assessment on the intensity, frequency, duration, and total years of RPA...
April 21, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28430967/associations-of-unhappiness-with-sociodemographic-factors-and-unhealthy-behaviours-in-chinese-adolescents
#3
Jianjiu Chen, Sai Yin Ho, Lok Tung Leung, Man Ping Wang, Tai Hing Lam
Evidence on the effects of lack of physical exercise, alcohol drinking and smoking on happiness is limited and inconsistent. We examined the associations of unhappiness with sociodemographic factors and these unhealthy behaviours in Chinese adolescents. In a school-based survey in 2012-13 in Hong Kong, 45 857 secondary school students (mean age 14.8 years, 54.0% boys) reported their happiness level (not happy at all/not very happy/happy/very happy), frequency of physical exercise, alcohol drinking status, smoking status and sociodemographic factors...
April 18, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28430740/low-dose-computed-tomography-scans-with-automatic-exposure-control-for-patients-of-different-ages-undergoing-cardiac-pet-ct-and-spect-ct
#4
Ching-Ching Yang, Bang-Hung Yang, Chun-Yuan Tu, Tung-Hsin Wu, Shu-Hsin Liu
PURPOSE: This study aimed to evaluate the efficacy of automatic exposure control (AEC) in order to optimize low-dose computed tomography (CT) protocols for patients of different ages undergoing cardiac PET/CT and single-photon emission computed tomography/computed tomography (SPECT/CT). METHODS: One PET/CT and one SPECT/CT were used to acquire CT images for four anthropomorphic phantoms representative of 1-year-old, 5-year-old and 10-year-old children and an adult...
April 20, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28429098/symptomatic-menopausal-transition-and-subsequent-bipolar-disorder-among-midlife-women-with-major-depression-a-nationwide-longitudinal-study
#5
Li-Chi Chen, Albert C Yang, Tung-Ping Su, Ya-Mei Bai, Cheng-Ta Li, Wen-Han Chang, Tzeng-Ji Chen, Shih-Jen Tsai, Mu-Hong Chen
Previous studies suggested that menopausal transition played an important role in the clinical course of major depression and bipolar disorder. However, the role of symptomatic menopausal transition in diagnostic conversion from major depression to bipolar disorder was still unknown. Using the Taiwan National Health Insurance Research Database, 50,273 midlife women aged between 40 and 60 years in 2002∼2008 with major depression were enrolled in our study and divided into two subgroups based on the presence (n = 21,120) or absence (n = 29,153) of symptomatic menopausal transition...
April 20, 2017: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/28429002/assembling-metallic-1t-mos2-nanosheets-with-inorganic-ligand-stabilized-quantum-dots-for-exceptional-solar-hydrogen-evolution
#6
Xu-Bing Li, Yu-Ji Gao, Hao-Lin Wu, Yang Wang, Qing Guo, Mao-Yong Huang, Bin Chen, Chen-Ho Tung, Li-Zhu Wu
Due to their enhanced light harvesting, favored interfacial charge transfer and excellent proton reduction activity, hybrid photocatalysts of metallic 1T-MoS2 nanosheets and inorganic-ligand stabilized CdSe/ZnS QDs obtained via a self-assembly approach can produce H2 gas with a rate of ∼155 ± 3.5 μmol h(-1) mg(-1) under visible-light irradiation (λ = 410 nm), the most exceptional performance of solar H2 evolution using MoS2 as a cocatalyst known to date.
April 21, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28428147/title-high-genetic-diversities-between-isolates-of-the-fish-parasite-cryptocaryon-irritans-ciliophora-suggest-multiple-cryptic-species
#7
Hongshu Chi, Patricia Taik, Emily J Foley, Alycia C Racicot, Hilary M Gray, Katherine E Guzzetta, Hsin-Yun Lin, Yen-Ling Song, Che-Huang Tung, Kosuke Zenke, Tomoyoshi Yoshinaga, Chao-Yin Cheng, Wei-Jen Chang, Hui Gong
The ciliate protozoan Cryptocaryon irritans parasitizes marine fish and causes lethal white spot disease. Sporadic infections as well as large-scale outbreaks have been reported globally and the parasite's broad host range poses particular threat to the aquaculture and ornamental fish markets. In order to better understand C. irritans' population structure, we sequenced and compared mitochondrial cox-1, SSU rRNA, and ITS-1 sequences from 8 new isolates of C. irritans collected in China, Japan, and Taiwan. We detected two SSU rRNA haplotypes, which differ at three positions, separating the isolates into two main groups (I and II)...
April 18, 2017: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/28428099/nipple-sparing-mastectomy-and-its-application-on-brca-gene-mutation-carrier
#8
REVIEW
Michael Co, Rosemarie Chiu, Tung Milly Chiu, Yau Chun Chong, Swan Lau, Yung Ho Lee, Hoi Man To, Ava Kwong
In breast cancer 1 (BRCA) gene mutation carriers, mastectomy is still the mainstay of treatment for breast cancers due to the increased risk of local recurrence. It is performed as a therapeutic, as well as prophylactic procedure. However, mastectomy with removal of nipple areolar complex (NAC) is associated with adverse cosmetic outcome. NAC sparing mastectomy (NSM), which results in better cosmetic outcome, has been performed in non-BRCA mutation carriers. While studies have shown that NSM is a oncologically safe in sporadic breast cancers, its application in BRCA mutation carriers is still controversial...
February 14, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28427977/decompressive-craniectomy-in-spontaneous-intracerebral-hemorrhage-a-case-control-study
#9
Yu Tung Lo, Angela An Qi See, Nicolas Kon Kam King
BACKGROUND: Decompressive craniectomy is performed to relieve intracranial pressure as an emergency procedure. There is no large study to systematically evaluate the benefit of decompressive craniectomy versus best medical therapy. This study evaluates the survival and long-term functional outcomes of decompressive craniectomy for spontaneous intracranial hemorrhage. METHODS: A total of 54 eligible patients with spontaneous supratentorial hemorrhage (median age 55, IQR 47-64) who underwent decompressive craniectomy were retrospectively matched to 72 patients managed with best medical treatment (median age 58, IQR 32-74)...
April 17, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28424749/development-of-asymmetric-facial-depigmentation-in-a-patient-treated-with-dasatinib-with-new-onset-hypovitaminosis-d-case-report-and-review-of-the-literature
#10
Kirsten C Webb, Magdalena Harasimowicz, Monica Janeczek, Jodi Speiser, James Swan, Rebecca Tung
Dasatinib is a second-generation tyrosine kinase inhibitor (TKI) used to treat imatinib-resistant chronic myelogenous leukemia (CML), as well as other Philadelphia chromosome-positive lymphoproliferative disorders. While the most commonly reported cutaneous side effects with this therapy include a morbilliform eruption, skin exfoliation, and skin irritation, pigmentary abnormalities have also been observed, albeit much more rarely. We present the case of a 72-year-old South Asian male with CML who presented with new-onset hypopigmentation of his face and scalp three years after a dose increase of dasatinib therapy, in the setting of newly discovered borderline hypovitaminosis D...
2017: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/28423661/examining-the-association-between-anthropometric-parameters-and-telomere-length-and-mortality-risk
#11
Chen-Jung Wu, Tung-Wei Kao, Yuan-Yung Lin, Fang-Yih Liaw, Li-Wei Wu, Yaw-Wen Chang, Tao-Chun Peng, Wei-Liang Chen
A shorter telomere length is associated with several systemic disorders. Telomere length may be an informative biomarker for the maintenance of the overall health status and mortality. There are a limited number of empirical studies concerning the effect of anthropometric parameters on telomere length. The data are derived from the National Health and Nutrition Examination Survey from 1999 to 2002. The primary outcomes of this study were to examine the potential relationships between the anthropometric indices and the telomere length, while secondary outcomes of this study was to investigate the association between different anthropometric indices and mortality risk...
March 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28422650/joint-magnetic-calibration-and-localization-based-on-expectation-maximization-for-tongue-tracking
#12
Jun Lu, Zhongtao Yang, Klaus Okkelberg, Maysam Ghovanloo
BACKGROUND: Tongue tracking, which helps researchers gain valuable insights into speech mechanism, has many applications in speech therapy and language learning. The wireless localization technique, which involves tracking a small magnetic tracer within the 3-D oral space, provides a low cost and convenient approach to capture tongue kinematics. In practice, this technique requires accurate calibration of 3-axial magnetic sensors used in the tracking system. The data-driven calibration depends on the trajectories of magnetic tracer and the ambient noise, which may change across time and space...
April 12, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28422079/synthetic-fluororutaecarpine-inhibits-inflammatory-stimuli-and-activates-endothelial-transient-receptor-potential-vanilloid-type-1
#13
Chi-Ming Lee, Jiun-An Gu, Tin-Gan Rau, Chi Wang, Chiao-Han Yen, Shih-Hao Huang, Feng-Yen Lin, Chun-Mao Lin, Sheng-Tung Huang
The natural product, rutaecarpine (RUT), is the main effective component of Evodia rutaecarpa which is a widely used traditional Chinese medicine. It has vasodilation, anticoagulation, and anti-inflammatory activities. However, further therapeutic applications are limited by its cytotoxicity. Thus, a derivative of RUT, 10-fluoro-2-methoxyrutaecarpine (F-RUT), was designed and synthesized that showed no cytotoxicity toward RAW264.7 macrophages at 20 μM. In an anti-inflammation experiment, it inhibited the production of nitric oxide (NO) and tumor necrosis factor (TNF)-α in lipopolysaccharide (LPS)-stimulated RAW264...
April 19, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28419251/evaluating-genetic-variants-associated-with-breast-cancer-risk-in-high-and-moderate-penetrance-genes-in-asians
#14
Mi-Ryung Han, Wei Zheng, Qiuyin Cai, Yu-Tang Gao, Ying Zheng, Manjeet K Bolla, Kyriaki Michailidou, Joe Dennis, Qin Wang, Alison M Dunning, Paul Brennan, Shou-Tung Chen, Ji-Yeob Choi, Mikael Hartman, Hidemi Ito, Artitaya Lophatananon, Keitaro Matsuo, Hui Miao, Kenneth Muir, Suleeporn Sangrajrang, Chen-Yang Shen, Soo Hwang Teo, Chiu-Chen Tseng, Anna H Wu, Cheng Har Yip, Daehee Kang, Yong-Bing Xiang, Douglas F Easton, Xiao-Ou Shu, Jirong Long
Over the past 20 years, high-penetrance pathogenic mutations in genes BRCA1, BRCA2, TP53, PTEN, STK11, and CDH1 and moderate-penetrance mutations in genes CHEK2, ATM, BRIP1, PALB2, RAD51C, RAD50, and NBN have been identified for breast cancer. In the present study, we investigated whether there are additional variants in these 13 genes associated with breast cancer among women of Asian ancestry. We analyzed up to 654 single nucleotide polymorphisms (SNPs) from 6269 cases and 6624 controls of Asian descent included in the Breast Cancer Association Consortium (BCAC), and up to 236 SNPs from 5794 cases and 5529 controls included in the Shanghai Breast Cancer Genetics Study (SBCGS)...
April 17, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28418646/the-influence-of-nanostructure-on-the-exciton-dynamics-of-multichromophore-donor-acceptor-block-copolymers
#15
Jianlong Xia, Erik Busby, Samuel N Sanders, Clarion Tung, Angelo Cacciuto, Matthew Y Sfeir, Luis M Campos
We explore the synthesis and photophysics of nanostructured block copolymers that mimic light harvesting complexes. We find that the combination of a polar and electron rich block with a non-polar electron poor block yields a polymer which self-assembles into ordered "nanoworms". Numerical simulations are used to determine optimal compositions to achieve robust self-assembly. Photolumi-nescence spectroscopy is used to probe the rich exciton dynamics in these systems. Using controls, such as homopolymers and random copolymers we analyze the mechanisms of the photoluminescence from these polymers...
April 18, 2017: ACS Nano
https://www.readbyqxmd.com/read/28418500/risk-of-uveitis-among-people-with-psoriasis-a-nationwide-cohort-study
#16
Ching-Chi Chi, Tao-Hsin Tung, Jui Wang, Yu-Sheng Lin, Yu-Fen Chen, Tsui-Kan Hsu, Shu-Hui Wang
Importance: Uveitis has been associated with psoriatic arthritis, but to our knowledge, the relationship between uveitis and psoriasis is unsettled among researchers. Objective: To evaluate the risk of incident uveitis among people with psoriasis. Design, Setting, and Participants: This nationwide, retrospective cohort study conducted in Taiwan from January 1, 2000, to December 31, 2012 included 147 954 people with psoriasis (including 10 107 with concomitant psoriatic arthritis and 137 847 without psoriatic arthritis) and 147 954 nonpsoriatic controls...
April 13, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28417351/detrimental-effect-of-maternal-and-post-weaning-high-fat-diet-on-the-reproductive-function-in-the-adult-female-offspring-rat-roles-of-insulin-like-growth-factor-2-and-the-ovarian-circadian-clock
#17
Yu-Ju Lin, Ching-Chou Tsai, Li-Tung Huang, Jiunn-Ming Sheen, Mao-Meng Tiao, Hong-Ren Yu, Chih-Cheng Chen, You-Lin Tain
PURPOSE: We evaluate the impact of maternal and post-weaning high-fat (HF) diet on ovarian follicular population, steroidogenesis, and gene expression with a focus on the circadian clock system and insulin-like growth factor 2 (Igf2) in adult offspring ovaries, and to elucidate whether a maternal and post-weaning diet confers similar risks. METHODS: Virgin Sprague-Dawley rats were fed with normal chow (C) diet or HF diet for 5 weeks before mating, during gestation, and lactation...
April 17, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28417089/demographic-and-medication-characteristics-of-traditional-chinese-medicine-users-among-colorectal-cancer-survivors-a-nationwide-database-study-in-taiwan
#18
Chien-Tung Wu, Yueh-Ting Tsai, Jung-Nien Lai
Chinese herbal product (CHP) is the major type of traditional Chinese medicine (TCM) and widely used to relief the symptom of colorectal cancer. The aim of the study was to analyze the utilization of CHP for treating patients with colorectal cancer in Taiwan. The usage of CHP, frequency of services, and prescription pattern for colorectal cancer were analyzed from a randomly sampled cohort of 1 million beneficiaries from the National Health Insurance Research Database. The odds ratios for utilization of CHP were estimated with logistic regression model...
April 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/28416268/post-traumatic-stress-disorder-and-risk-of-parkinson-disease-a-nationwide-longitudinal-study
#19
Yee-Lam E Chan, Ya-Mei Bai, Ju-Wei Hsu, Kai-Lin Huang, Tung-Ping Su, Cheng-Ta Li, Wei-Chen Lin, Tai-Long Pan, Tzeng-Ji Chen, Shih-Jen Tsai, Mu-Hong Chen
OBJECTIVE: Increasing evidence has suggested a relationship between post-traumatic stress disorder (PTSD) and neurodegenerative disorder, such as Alzheimer disease. The association between PTSD and Parkinson disease (PD), however, remains unclear. METHOD: Using the Taiwan National Health Insurance Research Database, 7,280 subjects (1,456 patients aged ≥45 years with PTSD and 5,824 age-/sex-matched individuals without PTSD) were enrolled between 2002 and 2009 and followed to the end of 2011...
March 23, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28416132/discovery-of-indazole-aldosterone-synthase-cyp11b2-inhibitors-as-potential-treatments-for-hypertension
#20
Scott B Hoyt, Jerry Taylor, Clare London, Amjad Ali, Feroze Ujjainwalla, Jim Tata, Mary Struthers, Doris Cully, Tom Wisniewski, Ning Ren, Charlene Bopp, Andrea Sok, Andreas Verras, Daniel McMasters, Qing Chen, Elaine Tung, Wei Tang, Gino Salituro, Joe Clemas, Gaochao Zhou, Douglas MacNeil, Ruth Duffy, Yusheng Xiong
We report the discovery and hit-to-lead optimization of a structurally novel indazole series of CYP11B2 inhibitors. Benchmark compound 34 from this series displays potent inhibition of CYP11B2, high selectivity versus related steroidal and hepatic CYP targets, and lead-like physical and pharmacokinetic properties. On the basis of these and other data, the indazole series was progressed to lead optimization for further refinement.
April 8, 2017: Bioorganic & Medicinal Chemistry Letters
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