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Yu-Ming Hsu, Fang-Rong Chang, I-Wen Lo, Kuei-Hung Lai, Mohamed El-Shazly, Tung-Ying Wu, Ying-Chi Du, Tsong-Long Hwang, Yuan-Bin Cheng, Yang-Chang Wu
Zoanthus kuroshio is a colorful zoanthid with a fluorescent pink oral disc and brown tentacles, which dominates certain parts of the Taiwanese and Japanese coasts. This sea anemone is a rich source of biologically active alkaloids. In the current investigation, two novel halogenated zoanthamines [5α-iodozoanthenamine (1) and 11β-chloro-11-deoxykuroshine A (2)], along with four new zoanthamines [18-epi-kuroshine A (3), 7α-hydroxykuroshine E (4), 5α-methoxykuroshine E (5), and 18-epi-kuroshine E (6)], and six known compounds were isolated from Z...
October 19, 2016: Journal of Natural Products
Chih-Ping Chen, Chen-Yu Chen, Tung-Yao Chang, Hsiu-Yu Yang, Yen-Ni Chen, Shin-Wen Chen, Wayseen Wang
No abstract text is available yet for this article.
October 2016: Taiwanese Journal of Obstetrics & Gynecology
Sheng-Ling Tung, Ting-Ywan Chou, Hung-Shi Tseng, Chi-Ming Lee
OBJECTIVE: To report our experiences with 40 patients who were treated with magnetic resonance-guided focused ultrasound surgery (MRgFUS) for uterine fibroids and their 6-month follow-up status. MATERIALS AND METHODS: A total of 40 patients with uterine fibroids underwent MRgFUS from January 2009 to November 2011. The Uterine Fibroid Symptoms and Quality of Life Questionnaire was used to determine the patients' Symptom Severity Scores (SSS) prior to and 6 months after treatment...
October 2016: Taiwanese Journal of Obstetrics & Gynecology
Chun-Che Huang, Yu-Tung Huang, Ming-Ping Wu
OBJECTIVE: Limited information is available on health issues during pregnancy and after childbirth among nurses, especially on a nationwide level. This study thus aimed to compare antenatal and perinatal complications between nurses and nonmedical working women in Taiwan. MATERIALS AND METHODS: This nationwide population-based study was conducted using data from the Taiwan National Health Insurance Research Database. A total of 44,166 nurses and 442,107 nonmedical working women with full-time employment, aged 20-50 years, who gave birth to singletons were identified between 2007 and 2011...
October 2016: Taiwanese Journal of Obstetrics & Gynecology
Zhi Wang, Ravithree Senanayake, Christine M Aikens, Wen-Miao Chen, Chen-Ho Tung, Di Sun
Here we report the single-crystal structure, experimental and theoretical characterization of a 41-metal atom Au-Ag alloy nanocluster [Au3Ag38(SCH2Ph)24X5](2-) (1, X = Cl or Br). The nanocluster 1 is co-protected by thiolate and halogen atoms and features an all-metallic face-fused biicosahedral Au2@AuAg20 rod-like kernel enwrapped by the outermost Ag18(SCH2Ph)24X3 shell. Two sites on the surface of the biicosahedral kernel are partially occupied by Au and Ag atoms. The outer Ag18(SCH2Ph)24X3 shell is composed of two Ag6S6 cycles at the two poles and one Ag6S2X3 arc at the equator with both 2- and 3-coordinated Ag atoms, which has not been observed in gold or silver nanoclusters ever before...
October 17, 2016: Nanoscale
Claire-Anne Gutekunst, Jack K Tung, Margaret E McDougal, Robert E Gross
Regrowth inhibitory molecules prevent axon regeneration in the adult mammalian central nervous system (CNS). RhoA, a small GTPase in the Rho family, is a key intracellular switch that mediates the effects of these extracellular regrowth inhibitors. The bacterial enzyme C3-ADP ribosyltransferase (C3) selectively and irreversibly inhibits the activation of RhoA and stimulates axon outgrowth and regeneration. However, effective intracellular delivery of the C3 protein in vivo is limited by poor cell permeability and a short duration of action...
October 13, 2016: Neuroscience
Yi-An Tu, Mu-Hong Chen, Chia-Fen Tsai, Tung-Ping Su, Ya-Mei Bai, Cheng-Ta Li, Wei-Chen Lin, Mu-En Liu, Tai-Long Pan, Tzeng-Ji Chen, Shih-Jen Tsai
OBJECTIVE: It was unclear whether older people without dementia who attempted suicide were at increased risk of subsequently developing dementia. METHODS: Using the Taiwan National Health Insurance Research Database, 1,189 patients aged ≥ 65 years who attempted suicide and 4,756 age- and sex-matched control subjects were enrolled in our study and followed to the end of 2011. Those who developed dementia during the follow-up were identified. RESULTS: Cox regression analysis, after adjusting for demographic data and medical comorbidities, found that geriatric suicide attempt was associated with an increased risk of subsequent dementia (HR: 7...
September 5, 2016: American Journal of Geriatric Psychiatry
Hsuan-Lun Lu, Tung-Wu Lu, Hsiu-Chen Lin, Hong-Jung Hsieh, Wing P Chan
Treadmills are often used in clinical settings to improve walking balance control in patients with gait impairments. However, knowledge of the effects of belt speed on balance control remains incomplete. The current study determined such effects in terms of inclination angles (IA) and the rate of change (RCIA) of the center of mass (COM) motion relative to the center of pressure (COP) in twelve healthy adults at five belt speeds, including the subjects' preferred walking speed (PWS), as measured using a motion capture system and an instrumented treadmill...
September 29, 2016: Gait & Posture
Renaud Massart, Matthew J Suderman, Zsofia Nemoda, Sheila Sutti, Angela M Ruggiero, Amanda M Dettmer, Stephen J Suomi, Moshe Szyf
The effects of social status on human health can be modeled in captive cohorts of nonhuman primates. This study shows that maternal social rank is associated with broad changes in DNA methylation in placentae of rhesus monkeys (N = 10). Differentially methylated genes between social ranks are enriched in signaling pathways playing major roles in placenta physiology. Moreover, the authors found significant overlaps with genes whose expression was previously associated with social rank in adult rhesus monkeys (Tung et al...
October 14, 2016: Child Development
Guo Jincun, Zhou Faguang, Huang Weibin, Wang Yan, Dong Kang, Roderick Tung
No abstract text is available yet for this article.
October 2016: Circulation. Arrhythmia and Electrophysiology
Alvin Ho-Kwan Cheung, Colin Siu-Chi Lam, Henry Shiu-Cheung Tam, Tan-To Cheung, Roberta Pang, Ronnie Tung-Ping Poon
BACKGROUND: Chemoembolization with doxorubucin-eluting beads (DEB) has been used to treat hepatocellular carcinoma (HCC) since 2007. This study compared the efficacy and survival between transarterial chemoembolization (TACE) with DEB and conventional approach (cTACE) in HCC treatment. METHODS: This retrospective case-control study compared the overall survival and tumor response of HCC patients to cTACE (n=190) and DEB (n=143) by the reassessment of computed tomography and serum alpha-fetoprotein (AFP)...
October 2016: Hepatobiliary & Pancreatic Diseases International: HBPD INT
Hong-Yan Zhuo, Hai-Feng Su, Zhao-Zhen Cao, Wei Liu, Shu-Ao Wang, Lei Feng, Gui-Lin Zhuang, Shui-Chao Lin, Mohamedally Kurmoo, Chen-Ho Tung, Di Sun, Lan-Sun Zheng
Cu(CF3 COO)2 reacts with tert-butylacetylene (tBuC≡CH) in methanol in the presence of metallic copper powder to give two air-stable clusters, [Cu(I)15 (tBuC≡C)10 (CF3 COO)5 ]⋅tBuC≡CH (1) and [Cu(I)16 (tBuC≡C)12 (CF3 COO)4 (CH3 OH)2 ] (2). The assembly process involves in situ comproportionation reaction between Cu(2+) and Cu(0) and the formation of two different clusters is controlled by reactants concentration. The clusters consist of Cu15 and Cu16 cores co-stabilized by strong by σ- and π-bonded tert-butylethynide and CF3 COO(-) (together with methanol molecule in 2)...
October 12, 2016: Chemistry: a European Journal
Yutong Shi, Chengqian Pan, Bibi Nazia Auckloo, Xuegang Chen, Chen-Tung Arthur Chen, Kuiwu Wang, Xiaodan Wu, Ying Ye, Bin Wu
Marine hydrothermal microorganisms respond rapidly to the changes in the concentrations and availability of metals within hydrothermal vent microbial habitats which are strongly influenced by elevated levels of heavy metals. Most hydrothermal vent actinomycetes possess a remarkable capability for the synthesis of a broad variety of biologically active secondary metabolites. Major challenges in the screening of these microorganisms are to activate the expression of cryptic biosynthetic gene clusters and the development of technologies for efficient dereplication of known compounds...
October 11, 2016: Applied Microbiology and Biotechnology
Van Trung Chu, Robin Graf, Tristan Wirtz, Timm Weber, Jeremy Favret, Xun Li, Kerstin Petsch, Ngoc Tung Tran, Michael H Sieweke, Claudia Berek, Ralf Kühn, Klaus Rajewsky
Applying clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR associated protein 9 (Cas9)-mediated mutagenesis to primary mouse immune cells, we used high-fidelity single guide RNAs (sgRNAs) designed with an sgRNA design tool (CrispRGold) to target genes in primary B cells, T cells, and macrophages isolated from a Cas9 transgenic mouse line. Using this system, we achieved an average knockout efficiency of 80% in B cells. On this basis, we established a robust small-scale CRISPR-mediated screen in these cells and identified genes essential for B-cell activation and plasma cell differentiation...
October 11, 2016: Proceedings of the National Academy of Sciences of the United States of America
Wei-Te Wu, Su-Shan Tsai, Yu-Jen Lin, Ming-Hsiu Lin, Trong-Neng Wu, Tung-Sheng Shih, Saou-Hsing Liou
BACKGROUND: Professional drivers' work under conditions predisposes them for development of sleep-disordered breathing (SDB) and cardiovascular disease (CVD). However, the effect of SDB on CVD risk among professional drivers has never been investigated. A cohort study was used to evaluate the effectiveness of overnight pulse oximeter as a sleep apnea screening tool to assess the 8-year risk of CVD events. METHODS: The Taiwan Bus Driver Cohort Study (TBDCS) recruited 1014 professional drivers in Taiwan since 2005...
September 29, 2016: International Journal of Cardiology
Rong-Peng Peng, Ling-Bao Xing, Xiao-Jun Wang, Cheng-Juan Wu, Bin Chen, Hai-Feng Ji, Li-Zhu Wu, Chen-Ho Tung
We developed a novel Pb(2+)-sensor based on a microcantilever that was modified with a specific Pb(2+)-dependent DNAzyme molecule. This microcantilever sensor could detect Pb(2+) sensitively and selectively in an aqueous solution. Upon complexation with Pb(2+), the DNAzyme duplex unwinded and formed a G-quadruplex conformation, which led to an increase of repulsion between the DNAzyme molecules and a subsequent bending of the microcantilever. This microcantilever sensor could be regenerated, flowing through a strong Pb(2+) chelator, 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid...
2016: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
Nobuhiro Takemae, Yugo Shobugawa, Phuong Thanh Nguyen, Tung Nguyen, Tien Ngoc Nguyen, Thanh Long To, Phuong Duy Thai, Tho Dang Nguyen, Duy Thanh Nguyen, Dung Kim Nguyen, Hoa Thi Do, Thi Quynh Anh Le, Phan Truong Hua, Hung Van Vo, Diep Thi Nguyen, Dang Hoang Nguyen, Yuko Uchida, Reiko Saito, Takehiko Saito
BACKGROUND: Influenza A viruses of swine (IAV-S) cause acute and subclinical respiratory disease. To increase our understanding of the etiology of the subclinical form and thus help prevent the persistence of IAV-S in pig populations, we conducted active virologic surveillance in Vietnam, the second-largest pig-producing country in Asia, from February 2010 to December 2013. RESULTS: From a total of 7034 nasal swabs collected from clinically healthy pigs at 250 farms and 10 slaughterhouses, we isolated 172 IAV-S from swine at the weaning and early-fattening stages...
October 10, 2016: BMC Veterinary Research
Sameer Agnihotri, Shahrzad Jalali, Mark R Wilson, Arnavaz Danesh, Mira Li, George Klironomos, Jonathan R Krieger, Alireza Mansouri, Osaama Khan, Yasin Mamatjan, Natalie Landon-Brace, Takyee Tung, Mark Dowar, Tiantian Li, Jeffrey P Bruce, Kelly E Burrell, Peter D Tonge, Amir Alamsahebpour, Boris Krischek, Pankaj Kumar Agarwalla, Wenya Linda Bi, Ian F Dunn, Rameen Beroukhim, Michael G Fehlings, Vera Bril, Stefano M Pagnotta, Antonio Iavarone, Trevor J Pugh, Kenneth D Aldape, Gelareh Zadeh
Schwannomas are common peripheral nerve sheath tumors that can cause debilitating morbidities. We performed an integrative analysis to determine genomic aberrations common to sporadic schwannomas. Exome sequence analysis with validation by targeted DNA sequencing of 125 samples uncovered, in addition to expected NF2 disruption, recurrent mutations in ARID1A, ARID1B and DDR1. RNA sequencing identified a recurrent in-frame SH3PXD2A-HTRA1 fusion in 12/125 (10%) cases, and genomic analysis demonstrated the mechanism as resulting from a balanced 19-Mb chromosomal inversion on chromosome 10q...
October 10, 2016: Nature Genetics
Min-Hsiung Pan, Yen-Chen Tung, Guliang Yang, Shiming Li, Chi-Tang Ho
Obesity is a serious health problem in adults and children worldwide. However, the basic strategies for the management of obesity (diet, exercise, drugs and surgery) have limitations and side effects. Therefore, many researchers have sought to identify bioactive components in food. Tea and coffee are the most frequently consumed beverages in the whole world. Their health benefits have been studied for decades, especially those of green tea. The anti-obesity effect of tea and coffee has been studied for at least ten years...
October 10, 2016: Food & Function
Olujimi A Ajijola, Jorge Romero, Gabriel Vorobiof, William M Suh, Kalyanam Shivkumar, Roderick Tung
No abstract text is available yet for this article.
November 2015: HeartRhythm Case Reports
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