keyword
https://read.qxmd.com/read/38533265/gut-microbiota-potential-therapeutic-target-for-sickle-cell-disease-pain-and-complications
#1
REVIEW
Tarimoboere Agbalalah, Doofan Bur, Ezinne JaneFrances Nwonu, Adekunle Babajide Rowaiye
AIM: Sickle cell disease has witnessed a 41.4% surge from 2000 to 2021, significantly affecting morbidity and mortality rates, particularly in children from regions with elevated under-5 mortality rates. Gut microbiota dysbiosis is increasingly recognised in SCD, exacerbating complications, particularly chronic pain, marked by significant alterations of proinflammatory bacteria abundance. This review explores the therapeutic potential of Akkermansia muciniphila and Roseburia spp. in alleviating SCD-related complications, emphasising their roles in maintaining gut barrier integrity, reducing inflammation, and modulating immune responses...
2024: Anemia
https://read.qxmd.com/read/38523830/a-saudi-woman-with-ceftriaxone-induced-fixed-drug-eruption
#2
Rehab Y Al-Ansari, Leena Abdulrahman Almuhaish, Khaled Abdullah Hassan, Tawasoul Fadoul, Alexander Woodman
BACKGROUND: A fixed drug eruption (FDE) is an immunological cutaneous adverse reaction, classified as a cutaneous adverse drug reaction (CADR) and characterized by well-defined lichenoid lesions that occur at the same site each time. Ceftriaxone is a third-generation antibiotic of cephalosporin antibiotics of the beta-lactam antibiotic family, which has typical in vitro activity against many Gram-negative aerobic bacteria. This is the first clinical case from Saudi Arabia and the fifth in the world to document a woman's experience with recurrent FDE after repeated ceftriaxone use...
2024: Case Reports in Dermatological Medicine
https://read.qxmd.com/read/38499723/the-associations-between-opioid-use-disorder-and-healthcare-related-outcomes-in-vaso-occlusive-crisis
#3
JOURNAL ARTICLE
Abdulsabur Sanni, Spencer Goble, David T Gilbertson, Dawn Johnson, Mark Linzer
BACKGROUND: In patients who experience frequent vaso-occlusive crises (VOC), opioid dependence may be due to a need for pain control as opposed to addiction; the implications of opioid use disorder (OUD) in this population are unclear. OBJECTIVE: To compare outcomes in hospitalizations for VOC in those with a history of OUD to those without a history of OUD. DESIGN: A retrospective assessment of hospitalizations for adults in the USA with a primary discharge diagnosis of VOC using the National Inpatient Sample database from 2016 to 2019...
March 18, 2024: Journal of General Internal Medicine
https://read.qxmd.com/read/38494406/sickle-cell-disease-and-increased-adverse-maternal-and-perinatal-outcomes-in-different-genotypes
#4
JOURNAL ARTICLE
Camilla Olivares Figueira, José Paulo S Guida, Fernanda G Surita, Arthur Antolini-Tavares, Sara T Saad, Fernando F Costa, Kleber Y Fertrin, Maria Laura Costa
BACKGROUND: Sickle cell disease (SCD) comprises a heterogeneous group of inherited hemolytic disorders that increases the risk of maternal and perinatal complications due to chronic systemic inflammatory response, endothelial damage and vaso-occlusion. The contribution of genotypes to the severity of outcomes during pregnancy is not completely established. METHODS: A retrospective study of medical charts was performed to compare maternal and perinatal outcomes in Hb SS, Hb SC disease and sickle-beta thalassemia (Hb Sβ) pregnancies followed at a high-risk antenatal care unit over a 6-year period...
March 14, 2024: Hematology, Transfusion and Cell Therapy
https://read.qxmd.com/read/38491141/aerobic-physical-capacity-and-health-related-quality-of-life-in-children-with-sickle-cell-disease
#5
JOURNAL ARTICLE
Corentin Laurent-Lacroix, Marie Vincenti, Stefan Matecki, Perrine Mahé, Lionel Moulis, Gregoire De La Villeon, Sophie Guillaumont, Anne Requirand, Johan Moreau, Muriel Lalande, Marie-Christine Picot, Pascal Amedro, Arthur Gavotto
BACKGROUND: Aerobic fitness is a predictor of cardiovascular health which correlates with health-related quality of life in the general population. The aim is to evaluate the aerobic capacity by cardiopulmonary exercise test (CPET) in children with sickle cell disease in comparison with healthy matched controls. METHODS: Controlled cross-sectional study. RESULTS: A total of 72 children (24 with sickle cell disease and 48 healthy controls), aged 6-17 years old were enrolled...
March 15, 2024: Pediatric Research
https://read.qxmd.com/read/38487039/exploring-factors-associated-with-quality-of-life-in-caregivers-of-children-and-adolescents-with-sickle-cell-disease-and-hiv-a-comparative-analysis
#6
JOURNAL ARTICLE
Charlotte Eposse Ekoube, Dora Mbonjo Bitsie, Erero F Njiengwe, Edgar Mandeng Ma Linwa, Christian Eyoum, Ritha Mbono Betoko, Jeannette Disso Massako, Emmanuel Heles Nsang, Abba Soumaiyatou, Callixte Tegueu Kuate
INTRODUCTION: Paediatric HIV and sickle cell disease (SCD) are two stigmatising and potentially fatal illnesses that place a significant burden on families. HIV patients benefit from a longstanding free-service national programme in Cameroon, and this could considerably alleviate burden of care on HIV caregivers, possibly leading to better quality of life (QoL) in HIV caregivers compared to SCD caregivers. Our study aimed to compare the QoL between caregivers of children and adolescents with SCD and HIV and explore factors associated with this QoL in Cameroon...
2024: Anemia
https://read.qxmd.com/read/38485550/influence-of-hydroxyurea-on-tubular-phosphate-handling-in-sickle-cell-nephropathy
#7
JOURNAL ARTICLE
Gabriela Araujo de Abreu, Duaran Lopes de Sousa, Suzzy Maria Carvalho Dantas, Alice Maria Costa Martins, Tiago Lima Sampaio, Romélia Pinheiro Gonçalves Lemes
OBJECTIVE: This study aims to evaluate the markers of tubular phosphate handling in adults with sickle cell anemia (SCA) and the influence of hydroxyurea (HU), the degree of anemia and Hb F concentration on these markers. METHODS: Eighty-eight steady state SCA patients in outpatient follow-up in Fortaleza, Ceara, Brazil and 31 healthy individuals were included in this study. Vitamin D (25OHD) was measured by enzyme-bound fluorescence assay, intact parathyroid hormone (iPTH) by electrochemiluminescence, and serum and urinary phosphate and creatinine by colorimetric methods...
February 14, 2024: Hematology, Transfusion and Cell Therapy
https://read.qxmd.com/read/38482309/how-healthy-is-the-health-budget-of-amrit-kaal-2023-24
#8
JOURNAL ARTICLE
Madan M Majhi, Anshita Mishra, Suneela Garg, Raman Kumar
Political will is the key to public health policy-making and a major driving force for the attainment of Universal Health Coverage (UHC) in any nation. To achieve UHC, the Indian government laid down National Health Policy in 1983 and updated it in 2002 and recently in 2017. This recent policy emphasized increasing healthcare spending and economic growth. In the current budget, there is an increment in the share of GDP of 0.34% from the previous year's allocation, but still staggering for the envisaged 2.5% to achieve UHC...
January 2024: Journal of Family Medicine and Primary Care
https://read.qxmd.com/read/38482084/a-rare-case-of-brodie-s-abscess-in-the-tibial-diaphysis-masquerading-as-a-vaso-occlusive-sickle-crisis
#9
Shefali Amin, Manish Shrestha, Sahil Amin, Suril Amin, Katherine DiPastina
We present the case of a 19-year-old male with a history of sickle cell anemia who presented to the hospital with worsening lower extremity pain. Given his acute presentation and history of recurrent pain crises, he was admitted to the hospital for management of a suspected acute pain crisis. However, due to continued pain, imaging was obtained which revealed a different diagnosis for the cause of his symptoms. MRI of the left lower leg revealed heterogenous T1 and T2 hyperintense signals within the proximal tibial diaphysis measuring 6...
2024: Journal of Community Hospital Internal Medicine Perspectives
https://read.qxmd.com/read/38472301/risk-factors-for-acute-chest-syndrome-among-children-with-sickle-cell-anemia-hospitalized-for-vaso-occlusive-crises
#10
JOURNAL ARTICLE
Faisal A Alghamdi, Fawaz Al-Kasim, Forat Alshhada, Eatedal Ghareeb, Fauzia R Azmet, Adel Almudaibigh, Lobna Baitalmal, Bedah Alnawfal, Rehab Alluqmani
Sickle cell anemia (SCA) is a globally prevalent inherited condition, with acute chest syndrome (ACS) being one of its most severe complications. ACS frequently leads to hospitalization, requires intensive care unit (ICU) admission, and can even result in death. This study aimed to discern the early indicators of impending ACS in children with SCA who were initially hospitalized due to painful vaso-occlusive crises (VOC). This was a retrospective, case‒control investigation of 120 patients aged 1-14 years seen at the King Saud Medical City in Riyadh, Saudi Arabia from January 2021 to December 2022...
March 12, 2024: Scientific Reports
https://read.qxmd.com/read/38469996/description-of-a-national-multi-center-registry-of-patients-with-sickle-cell-disease-and-sars-cov-2-infection-data-from-the-pediatric-covid-19-united-states-registry
#11
JOURNAL ARTICLE
Aleksandra S Dain, Caroline Diorio, Brian T Fisher, Jane S Hankins, Char M Witmer, Mickael Boustany, Madeline Burton, Jose Ferrolino, Salma Sadaf, Hailey S Ross, Gabriela Maron
Children with sickle cell disease (SCD) are at risk of complications from viral infections, including SARS-CoV-2. We present the clinical characteristics and outcomes of pediatric patients with SCD from the Pediatric COVID-19 United States Registry who developed acute COVID-19 due to SARS-CoV-2 infection (n = 259) or multisystem inflammatory syndrome in children (MIS-C; n = 4). Nearly half of hospitalized children with SCD and SARS-CoV-2 infection required supplemental oxygen, though children with SCD had fewer intensive care (ICU) admissions compared to the general pediatric and immunocompromised populations...
March 12, 2024: Pediatric Blood & Cancer
https://read.qxmd.com/read/38468842/impact-of-hydroxyurea-on-clinical-and-biological-parameters-of-sickle-cell-anemia-in-children-in-abidjan
#12
JOURNAL ARTICLE
Mireille Yayo-Aye, Adia Eusèbe Adjambri, Boidy Kouakou, Rebecca N'guessan-Blao, Louis Missa Adjé, Tairatou Kamagaté, Vincent Yapo, Duni Sawadogo
No abstract text is available yet for this article.
2024: Mediterranean Journal of Hematology and Infectious Diseases
https://read.qxmd.com/read/38465108/migrant-pathology-screening-in-the-pediatric-population-a-five-year-retrospective-study-from-a-level-ii-hospital
#13
JOURNAL ARTICLE
Luísa Castello-Branco Ribeiro, Filipa Paixão, Francisca Costa, Paula Correia
INTRODUCTION: The migrant population residing in Portugal has been growing. In 2015, the pediatrics department at Professor Doutor Fernando Fonseca Hospital, a level II hospital, implemented a screening for endemic pathologies in asymptomatic migrant children to enable their timely diagnosis and treatment. This study aimed to identify and characterize the main findings in the migrant pathology screening. METHODS: This was a retrospective and descriptive study of asymptomatic children and adolescents who underwent opportunistic screening for migrant pathology in a hospital setting between January 2016 and April 2021...
February 2024: Curēus
https://read.qxmd.com/read/38462769/prevalence-of-duffy-null-and-its-impact-on-hydroxyurea-in-young-children-with-sickle-cell-disease-in-the-united-states
#14
JOURNAL ARTICLE
Fathia Oladipupo, Joseph Stanek, Joseph Walden, Jennifer Young, Melissa J Rose, Kathleen Nicol, Anthony Villella, Susan Creary
Consistent with studies showing a high prevalence of the Duffy null phenotype among healthy Black Americans, this retrospective study found that Duffy null was present in >75% of a young and contemporary cohort of children with sickle cell disease (SCD) in the United States. Despite the potential for this phenotype to impact absolute neutrophil counts, hydroxyurea (HU) dosing, and outcomes, it was not associated with being prescribed a lower HU dose or having increased acute SCD visits early in the HU treatment course...
March 10, 2024: Pediatric Blood & Cancer
https://read.qxmd.com/read/38455804/compare-the-efficacy-and-safety-of-deferoxamine-deferasirox-and-deferiprone-in-patients-with-sickle-cell-disease-or-transfusion-dependent-anemia-a-network-meta-analysis-of-randomized-control-trials
#15
REVIEW
Divine Besong Arrey Agbor, Abhimanyu Karumanchi, Santoshini Adivi, Mohammed A Mohammed, Wajeeh Ur Rehman, Sandipkumar S Chaudhari, Thin M Soe, Neelum Ali
This network meta-analysis was conducted with the aim of comparing the efficacy and safety of deferiprone (DFP), deferasirox (DFX), and deferoxamine (DFO) in individuals with sickle cell disease (SCD) or transfusion-dependent anemia. This systematic review and meta-analysis adhered to the "Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)" guidelines. The search was conducted on electronic databases, including PubMed, CINAHIL, and EMBASE, from the inception of databases to January 10, 2024...
February 2024: Curēus
https://read.qxmd.com/read/38451648/dental-caries-in-the-permanent-dentition-and-health-related-quality-of-life-among-children-and-adolescents-with-sickle-cell-disease
#16
JOURNAL ARTICLE
Vera Lúcia Duarte da Costa Mendes, Patrícia A Risso, Marcia Pereira Alves Dos Santos
The aim was to associate living, health and oral health conditions with the quality of life (QL) of children and adolescents (CA) with sickle cell disease (SCD). Of the 120 eligible users of a public hematological service, 106 CA with SCD from 6 to 18 years of age, and their caregivers, answered semi-structured questions about socio-demographic, health and oral health conditions. For QL, we used the validated instrument PedsQLSCD™. The oral clinical examination occurred according to the guidelines of WHO and SB Brazil 2010...
March 2024: Ciência & Saúde Coletiva
https://read.qxmd.com/read/38444351/assessing-the-quality-of-care-for-children-with-sickle-cell-anemia-we-are-still-failing
#17
JOURNAL ARTICLE
Susan Creary, Sarah Reeves
No abstract text is available yet for this article.
March 6, 2024: Pediatrics
https://read.qxmd.com/read/38444343/national-quality-indicators-in-pediatric-sickle-cell-anemia
#18
JOURNAL ARTICLE
Ashaunta T Anderson, Wendy J Mack, Sophia S Horiuchi, Susan Paulukonis, Mei Zhou, Angela B Snyder, Jason N Doctor, Michele Kipke, Thomas Coates, Gary Freed
OBJECTIVE: To assess nationally endorsed claims-based quality measures in pediatric sickle cell anemia (SCA). METHODS: Using data from the Sickle Cell Data Collection programs in California and Georgia from 2010 to 2019, we evaluated 2 quality measures in individuals with hemoglobin S/S or S/β-zero thalassemia: (1) the proportion of patients aged 3 months to 5 years who were dispensed antibiotic prophylaxis for at least 300 days within each measurement year and (2) the proportion of patients aged 2 to 15 years who received at least 1 transcranial Doppler ultrasound (TCD) within each measurement year...
March 6, 2024: Pediatrics
https://read.qxmd.com/read/38443706/harmonizing-definitions-for-hematopoietic-recovery-graft-rejection-graft-failure-poor-graft-function-and-donor-chimerism-in-allogeneic-hematopoietic-cell-transplantation-a-report-on-behalf-of-the-ebmt-astct-cibmtr-and-apbmt
#19
JOURNAL ARTICLE
Anna Sureda, Paul A Carpenter, Andrea Bacigalupo, Vijaya Raj Bhatt, Josu de la Fuente, Aloysius Ho, Leslie Kean, Jong Wook Lee, Isabel Sánchez-Ortega, Bipin N Savani, Johannes Schetelig, Edward A Stadtmauer, Yoshiyuki Takahashi, Yoshiko Atsuta, John Koreth, Nicolaus Kröger, Per Ljungman, Shinichiro Okamoto, Uday Popat, Robert Soiffer, Heather E Stefanski, Mohamed A Kharfan-Dabaja
Despite emergence of novel therapies to treat hematologic malignancies, allogeneic hematopoietic cell transplantation (allo-HCT) remains an essential treatment modality capable of curing these diseases. Allo-HCT has been also shown to be curative in benign hematologic disorders such as aplastic anemia, sickle cell disease, and thalassemia, among others. Recently, the American Society for Transplantation and Cellular Therapy (ASTCT) published standardized definitions for hematopoietic recovery, graft rejection, graft failure, poor graft function, and donor chimerism...
March 5, 2024: Bone Marrow Transplantation
https://read.qxmd.com/read/38434462/predictors-of-developing-a-complex-course-of-osteomyelitis-in-patients-with-sickle-cell-anaemia
#20
JOURNAL ARTICLE
Al Zahra Al Hashmi, Ethar Al Fazari, Mustafa Al Ward, Reema Al Masruri, Shahad Al Balushi, Mohammed Al Mutani, Ahmed Al Ghaithi, Wafa Al Baluki
OBJECTIVES: Despite the numerous advances in management strategies, treating osteomyelitis in individuals with sickle cell disease (SCD) remains a significant challenge, leading to severe long-term consequences. This study aimed to assess the key factors potentially linked to a complex progression of osteomyelitis in patients diagnosed with SCD. METHODS: A cohort of 34 patients was identified and their progress was monitored over a span of 12 months during a 10-year period (2010-2020)...
February 2024: Sultan Qaboos University Medical Journal
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