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https://www.readbyqxmd.com/read/27907905/association-of-high-microvessel-%C3%AE-v%C3%AE-3-and-low-pten-with-poor-outcome-in-stage-3-neuroblastoma-rationale-for-using-first-in-class-dual-pi3k-brd4-inhibitor-sf1126
#1
Anat Erdreich-Epstein, Alok R Singh, Shweta Joshi, Francisco M Vega, Pinzheng Guo, Jingying Xu, Susan Groshen, Wei Ye, Melissa Millard, Mihaela Campan, Guillermo Morales, Joseph R Garlich, Peter W Laird, Robert C Seeger, Hiroyuki Shimada, Donald L Durden
Neuroblastoma (NB) is the most common extracranial solid tumor in children. Our previous studies showed that the angiogenic integrin αvβ3 was increased in high-risk metastatic (stage 4) NB compared with localized neuroblastomas. Herein, we show that integrin αvβ3 was expressed on 68% of microvessels in MYCN-amplified stage 3 neuroblastomas, but only on 34% (means) in MYCN-non-amplified tumors (p < 0.001; n = 54). PTEN, a tumor suppressor involved in αvβ3 signaling, was expressed in neuroblastomas either diffusely, focally or not at all (immunohistochemistry)...
November 16, 2016: Oncotarget
https://www.readbyqxmd.com/read/27629268/bioaccumulation-and-effects-of-metals-on-oxidative-stress-and-neurotoxicity-parameters-in-the-frogs-from-the-pelophylax-esculentus-complex
#2
Marko D Prokić, Slavica S Borković-Mitić, Imre I Krizmanić, Jelena J Mutić, Jelena Đ Trifković, Jelena P Gavrić, Svetlana G Despotović, Branka R Gavrilović, Tijana B Radovanović, Slađan Z Pavlović, Zorica S Saičić
Metals are involved in the formation of reactive oxygen species and can induce oxidative stress. The aim of this study was to assess the effects of several metals on oxidative stress in the skin and muscle of the Pelophylax esculentus "complex" frogs (parental species Pelophylax ridibundus, Pelophylax lessonae, and their hybrid Pelophylax esculentus) that inhabit the wetland Obedska Bara in Serbia, and the potential use of these species as bioindicator organisms in biomonitoring studies. The biomarkers of oxidative stress (SOD, CAT, GSH-Px, GR, GST activities and GSH, SH concentrations) and cholinesterase activity were investigated...
September 15, 2016: Ecotoxicology
https://www.readbyqxmd.com/read/27466195/selective-release-of-muscle-specific-extracellular-micrornas-during-myogenic-differentiation
#3
Anna M L Coenen-Stass, Corinne A Betts, Yi F Lee, Imre Mäger, Mikko P Turunen, Samir El Andaloussi, Jennifer E Morgan, Matthew J A Wood, Thomas C Roberts
MyomiRs are muscle-specific microRNAs (miRNAs) that regulate myoblast proliferation and differentiation. Extracellular myomiRs (ex-myomiRs) are highly enriched in the serum of Duchenne Muscular Dystrophy (DMD) patients and dystrophic mouse models and consequently have potential as disease biomarkers. The biological significance of microRNAs present in the extracellular space is not currently well understood. Here we demonstrate that ex-myomiR levels are elevated in perinatal skeletal muscle, during the regenerative phase that follows exercise-induced myoinjury, and concomitant with myoblast differentiation in culture...
July 27, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/27278241/development-of-an-ultra-high-sensitive-immunoassay-with-plasma-biomarker-for-differentiating-parkinson-disease-dementia-from-parkinson-disease-using-antibody-functionalized-magnetic-nanoparticles
#4
Shieh-Yueh Yang, Ming-Jang Chiu, Chin-Hsien Lin, Herng-Er Horng, Che-Chuan Yang, Jen-Jie Chieh, Hsin-Hsien Chen, Bing-Hsien Liu
BACKGROUND: It is difficult to discriminate healthy subjects and patients with Parkinson disease (PD) or Parkinson disease dementia (PDD) by assaying plasma α-synuclein because the concentrations of circulating α-synuclein in the blood are almost the same as the low-detection limit using current immunoassays, such as enzyme-linked immunosorbent assay. In this work, an ultra-sensitive immunoassay utilizing immunomagnetic reduction (IMR) is developed. The reagent for IMR consists of magnetic nanoparticles functionalized with antibodies against α-synuclein and dispersed in pH-7...
2016: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/27230444/emphysema-and-airway-dominant-copd-phenotypes-defined-by-standardised-quantitative-computed-tomography
#5
Deepak R Subramanian, Sumit Gupta, Dorothe Burggraf, Suzan J Vom Silberberg, Irene Heimbeck, Marion S Heiss-Neumann, Karl Haeussinger, Chris Newby, Beverley Hargadon, Vimal Raj, Dave Singh, Umme Kolsum, Thomas P Hofer, Khaled Al-Shair, Niklas Luetzen, Antje Prasse, Joachim Müller-Quernheim, Giorgio Benea, Stefano Leprotti, Piera Boschetto, Dorota Gorecka, Adam Nowinski, Karina Oniszh, Wolfgang Zu Castell, Michael Hagen, Imre Barta, Balázs Döme, Janos Strausz, Timm Greulich, Claus Vogelmeier, Andreas R Koczulla, Ivo Gut, Jens Hohlfeld, Tobias Welte, Mahyar Lavae-Mokhtari, Loems Ziegler-Heitbrock, Christopher Brightling, David G Parr
EvA (Emphysema versus Airway disease) is a multicentre project to study mechanisms and identify biomarkers of emphysema and airway disease in chronic obstructive pulmonary disease (COPD). The objective of this study was to delineate objectively imaging-based emphysema-dominant and airway disease-dominant phenotypes using quantitative computed tomography (QCT) indices, standardised with a novel phantom-based approach.441 subjects with COPD (Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages 1-3) were assessed in terms of clinical and physiological measurements, laboratory testing and standardised QCT indices of emphysema and airway wall geometry...
July 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/27174238/extracellular-vesicles-in-neurodegenerative-disease-pathogenesis-to-biomarkers
#6
REVIEW
Alexander G Thompson, Elizabeth Gray, Sabrina M Heman-Ackah, Imre Mäger, Kevin Talbot, Samir El Andaloussi, Matthew J Wood, Martin R Turner
To develop effective disease-modifying therapies for neurodegenerative diseases, reliable markers of diagnosis, disease activity and progression are a research priority. The fact that neurodegenerative pathology is primarily associated with distinct subsets of cells in discrete areas of the CNS makes the identification of relevant biomarker molecules a challenge. The trafficking of macromolecules from the CNS to the cerebrospinal fluid and blood, mediated by extracellular vesicles (EVs), presents a promising source of CNS-specific biomarkers...
June 2016: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/26846240/biomarkers-of-oxidative-stress-and-metal-accumulation-in-marsh-frog-pelophylax-ridibundus
#7
Slavica S Borković-Mitić, Marko D Prokić, Imre I Krizmanić, Jelena Mutić, Jelena Trifković, Jelena Gavrić, Svetlana G Despotović, Branka R Gavrilović, Tijana B Radovanović, Slađan Z Pavlović, Zorica S Saičić
To understand the effect of metals on the marsh frog Pelophylax ridibundus and the possible environment-induced changes in oxidative stress enzymes, we determined the concentrations of 18 metals: Al, As, Ba, Ca, Cd, Co, Cr, Cu, Fe, Ga, Hg, In, Li, Mn, Ni, Pb, Sr, and Zn, in the tissues (liver, skin, and muscle) and water samples collected from different locations in Serbia. The activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR), glutathione S-transferase (GST), acetylcholinesterase (AChE), and changes in concentrations of reduced glutathione (GSH) and sulfhydryl groups (SH) were analyzed in the tissues of the sampled frogs...
May 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/26608198/extracellular-micrornas-in-membrane-vesicles-and-non-vesicular-carriers
#8
Anna M L Coenen-Stass, Imre Mäger, Mathew J A Wood
Great excitement has surrounded the finding that small RNAs are stable in various biofluids and carry specific signatures reflecting physiological and pathological states. In this chapter, we briefly describe the impact of this revolutionary discovery and introduce different subclasses of circulating microRNAs based on their mode of transport. Subsequently, we review the current state-of-the art knowledge on microRNA selection for export, secretion and possible uptake mechanisms and their potential function in circulation...
2015: EXS
https://www.readbyqxmd.com/read/26469522/identification-of-ddx39a-as-a-potential-biomarker-for-unfavorable-neuroblastoma-using-a-proteomic-approach
#9
Kohei Otake, Keiichi Uchida, Shozo Ide, Yuhko Kobayashi, Issei Kobayashi, Masato Kusunoki
BACKGROUND: Malignant potential in unfavorable neuroblastoma (NB) is dependent on an undifferentiated status. The aim of this study was to identify a novel biomarker associated with the undifferentiated status of NB in vitro and to evaluate its prognostic implication. PROCEDURE: Shotgun proteomic analysis was performed in undifferentiated and all trans-retinoic acid induced differentiated NB cells in vitro. An identified protein was verified by multiple reaction monitoring (MRM) and evaluated by Western blot analysis...
February 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/26064421/endogenous-estrogen-mediated-heme-oxygenase-regulation-in-experimental-menopause
#10
Anikó Pósa, Renáta Szabó, Anett Csonka, Médea Veszelka, Anikó Magyariné Berkó, Zoltán Baráth, Rudolf Ménesi, Imre Pávó, Mariann Gyöngyösi, Ferenc László, Krisztina Kupai, Csaba Varga
Estrogen deficiency is one of the main causes of age-associated diseases in the cardiovascular system. Female Wistar rats were divided into four experimental groups: pharmacologically ovariectomized, surgically ovariectomized, and 24-month-old intact aging animals were compared with a control group. The activity and expression of heme oxygenases (HO) in the cardiac left ventricle, the concentrations of cardiac interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α), the myeloperoxidase (MPO) activity in the cardiac left ventricle, and the effects of heme oxygenase blockade (by 24-hour and 1-hour pretreatment with tin-protoporphyrin IX, SnPP) on the epinephrine and phentolamine-induced electrocardiogram ST segment changes in vivo were investigated...
2015: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/26022510/serum-free-culture-alters-the-quantity-and-protein-composition-of-neuroblastoma-derived-extracellular-vesicles
#11
Jinghuan Li, Yi Lee, Henrik J Johansson, Imre Mäger, Pieter Vader, Joel Z Nordin, Oscar P B Wiklander, Janne Lehtiö, Matthew J A Wood, Samir El Andaloussi
Extracellular vesicles (EVs) play a significant role in cell-cell communication in numerous physiological processes and pathological conditions, and offer promise as novel biomarkers and therapeutic agents for genetic diseases. Many recent studies have described different molecular mechanisms that contribute to EV biogenesis and release from cells. However, little is known about how external stimuli such as cell culture conditions can affect the quantity and content of EVs. While N2a neuroblastoma cells cultured in serum-free (OptiMEM) conditions did not result in EVs with significant biophysical or size differences compared with cells cultured in serum-containing (pre-spun) conditions, the quantity of isolated EVs was greatly increased...
2015: Journal of Extracellular Vesicles
https://www.readbyqxmd.com/read/25944577/serum-lipids-and-cardiac-function-correlate-with-nitrotyrosine-and-mmp-activity-in-coronary-artery-disease-patients
#12
Péter Bencsik, Viktor Sasi, Krisztina Kiss, Krisztina Kupai, Márton Kolossváry, Pál Maurovich-Horvat, Tamás Csont, Imre Ungi, Béla Merkely, Péter Ferdinandy
AIMS: Peroxynitrite-matrix metalloproteinase (MMP) signalling has been shown to contribute to myocardial ischaemia/reperfusion injury and heart failure and to be influenced by hyperlipidaemia in preclinical models. Therefore, here we investigated the correlation between the markers of peroxynitrite-MMP signalling and hyperlipidaemia in patients with significant coronary stenosis. METHODS: Five minutes before percutaneous coronary intervention (PCI), arterial blood samples were collected from 36 consecutive patients with coronary artery disease (CAD) selected for elective PCI...
July 2015: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/25801701/evaluation-of-multixenobiotic-resistance-in-dreissenid-mussels-as-a-screening-tool-for-toxicity-in-freshwater-sediments
#13
A Ács, K Imre, Gy Kiss, J Csaba, J Győri, Á Vehovszky, A Farkas
The multixenobiotic defense mechanism (MXR) in aquatic organisms was recognized as a first-line defense system, and its potential use as an early biomarker of exposure to environmental stress has raised attention in the last two decades. To evaluate the relevance of this biomarker in the freshwater mussel Dreissena polymorpha, we studied its responsiveness within laboratory exposures to contaminants sequestered in freshwater sediments affected by moderate anthropogenic impact. The effectiveness of this biomarker was assessed by comparing the MXR-transporter activities determined in bivalves first with toxicity scores recorded with the D...
May 2015: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/25659648/ultrafiltration-with-size-exclusion-liquid-chromatography-for-high-yield-isolation-of-extracellular-vesicles-preserving-intact-biophysical-and-functional-properties
#14
Joel Z Nordin, Yi Lee, Pieter Vader, Imre Mäger, Henrik J Johansson, Wolf Heusermann, Oscar P B Wiklander, Mattias Hällbrink, Yiqi Seow, Jarred J Bultema, Jonathan Gilthorpe, Tim Davies, Paul J Fairchild, Susanne Gabrielsson, Nicole C Meisner-Kober, Janne Lehtiö, C I Edvard Smith, Matthew J A Wood, Samir El Andaloussi
UNLABELLED: Extracellular vesicles (EVs) are natural nanoparticles that mediate intercellular transfer of RNA and proteins and are of great medical interest; serving as novel biomarkers and potential therapeutic agents. However, there is little consensus on the most appropriate method to isolate high-yield and high-purity EVs from various biological fluids. Here, we describe a systematic comparison between two protocols for EV purification: ultrafiltration with subsequent liquid chromatography (UF-LC) and differential ultracentrifugation (UC)...
May 2015: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/25408231/mek1-is-associated-with-carboplatin-resistance-and-is-a-prognostic-biomarker-in-epithelial-ovarian-cancer
#15
Zsófia Pénzváltó, András Lánczky, Julianna Lénárt, Nóra Meggyesházi, Tibor Krenács, Norbert Szoboszlai, Carsten Denkert, Imre Pete, Balázs Győrffy
BACKGROUND: Primary systemic treatment for ovarian cancer is surgery, followed by platinum based chemotherapy. Platinum resistant cancers progress/recur in approximately 25% of cases within six months. We aimed to identify clinically useful biomarkers of platinum resistance. METHODS: A database of ovarian cancer transcriptomic datasets including treatment and response information was set up by mining the GEO and TCGA repositories. Receiver operator characteristics (ROC) analysis was performed in R for each gene and these were then ranked using their achieved area under the curve (AUC) values...
November 18, 2014: BMC Cancer
https://www.readbyqxmd.com/read/24948432/effect-of-telomere-length-on-survival-in-patients-with-idiopathic-pulmonary-fibrosis-an-observational-cohort-study-with-independent-validation
#16
Bridget D Stuart, Joyce S Lee, Julia Kozlitina, Imre Noth, Megan S Devine, Craig S Glazer, Fernando Torres, Vaidehi Kaza, Carlos E Girod, Kirk D Jones, Brett M Elicker, Shwu-Fan Ma, Rekha Vij, Harold R Collard, Paul J Wolters, Christine Kim Garcia
BACKGROUND: Short telomere lengths are found in a subset of patients with idiopathic pulmonary fibrosis, but their clinical significance is unknown. Our aim was to investigate whether patients with various blood leucocyte telomere lengths had different overall survival. METHODS: In this observational cohort study, we enrolled patients with interstitial lung disease from Dallas, TX (primary cohort), and from Chicago, IL, and San Francisco, CA (replication cohorts)...
July 2014: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/24714447/sputum-eicosanoid-profiling-in-exacerbations-of-chronic-obstructive-pulmonary-disease
#17
Orsolya Drozdovszky, Imre Barta, Balazs Antus
BACKGROUND: Eicosanoids are small lipid molecules with diverse biological functions in the airways. OBJECTIVES: The aim of this study was to investigate changes in leukotriene B4 (LTB4), 8-isoprostane, prostaglandin E2 (PGE2) and cysteinyl-leukotriene (cys-LT) levels in the sputum of patients with chronic obstructive pulmonary disease (COPD) at the onset of a severe exacerbation and during the course of recovery. METHODS: Thirty-seven ex-smoker COPD patients suffering an episode of acute exacerbation were enrolled...
2014: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/24089408/peripheral-blood-mononuclear-cell-gene-expression-profiles-predict-poor-outcome-in-idiopathic-pulmonary-fibrosis
#18
Jose D Herazo-Maya, Imre Noth, Steven R Duncan, Sunghwan Kim, Shwu-Fan Ma, George C Tseng, Eleanor Feingold, Brenda M Juan-Guardela, Thomas J Richards, Yves Lussier, Yong Huang, Rekha Vij, Kathleen O Lindell, Jianmin Xue, Kevin F Gibson, Steven D Shapiro, Joe G N Garcia, Naftali Kaminski
We aimed to identify peripheral blood mononuclear cell (PBMC) gene expression profiles predictive of poor outcomes in idiopathic pulmonary fibrosis (IPF) by performing microarray experiments of PBMCs in discovery and replication cohorts of IPF patients. Microarray analyses identified 52 genes associated with transplant-free survival (TFS) in the discovery cohort. Clustering the microarray samples of the replication cohort using the 52-gene outcome-predictive signature distinguished two patient groups with significant differences in TFS...
October 2, 2013: Science Translational Medicine
https://www.readbyqxmd.com/read/23911438/functional-promoter-variants-in-sphingosine-1-phosphate-receptor-3-associate-with-susceptibility-to-sepsis-associated-acute-respiratory-distress-syndrome
#19
Xiaoguang Sun, Shwu-Fan Ma, Michael S Wade, Marialbert Acosta-Herrera, Jesús Villar, Maria Pino-Yanes, Tong Zhou, Bin Liu, Patrick Belvitch, Jaideep Moitra, Yoo-Jeong Han, Roberto Machado, Imre Noth, Viswanathan Natarajan, Steven M Dudek, Jeffrey R Jacobson, Carlos Flores, Joe G N Garcia
The genetic mechanisms underlying the susceptibility to acute respiratory distress syndrome (ARDS) are poorly understood. We previously demonstrated that sphingosine 1-phosphate (S1P) and the S1P receptor S1PR3 are intimately involved in lung inflammatory responses and vascular barrier regulation. Furthermore, plasma S1PR3 protein levels were shown to serve as a biomarker of severity in critically ill ARDS patients. This study explores the contribution of single nucleotide polymorphisms (SNPs) of the S1PR3 gene to sepsis-associated ARDS...
October 1, 2013: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/23711497/effects-of-glucose-restriction-on-replicative-senescence-of-human-diploid-fibroblasts-imr-90
#20
Junhua Jin, Tiemei Zhang
Background/Aims:. The aim of this study was to elucidate the effects of glucose restriction (GR) on cell replicative senescence in vitro by human diploid fibroblasts IMR-90. Methods: IMR-90 cells were cultured under 40, 60% GR or high glucose medium and biomarkers of cell senescence were compared with cells cultured in normal glucose medium (5.5 mM glucose). The impact of different concentrations of glucose and initial passages on cell replicative senescence were assessed by cell survival days, cumulative population doublings (PD), cell proliferation rate (CPR) and SA-β-gal site-stain...
2013: Cellular Physiology and Biochemistry
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