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https://www.readbyqxmd.com/read/28649694/immunohistochemical-expression-profiles-of-mucin-antigens-in-salivary-gland-mucoepidermoid-carcinoma-muc4-and-muc6-negative-expression-predicts-a-shortened-survival-in-the-early-postoperative-phase
#1
Kie Honjo, Tsubasa Hiraki, Michiyo Higashi, Hirotsugu Noguchi, Mitsuharu Nomoto, Takuya Yoshimura, Surinder K Batra, Suguru Yonezawa, Ichiro Semba, Norifumi Nakamura, Akihide Tanimoto, Sohsuke Yamada
In mucoepidermoid carcinoma (MEC), the most common salivary gland carcinoma, there is a lack of novel prognostic markers, but post-operative early recurrence strongly affects the clinical course and a poor outcome. It is critical to predict which MEC patients are prone to develop recurrence/metastases. Mucins play pivotal roles in influencing cancer biology, thus affecting cell differentiation, adhesion, carcinoma invasion, aggressiveness and/or metastatic potential. Our aim is to elucidate the significance of expression profiles for mucins, particularly MUC4 and MUC6, and their correlations with various clinicopathological features and recurrence in salivary gland MECs...
June 26, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28649589/data-supporting-the-anticancer-activity-of-posterior-salivary-gland-psg-toxin-from-the-cuttlefish-sepia-pharaonis-ehrenberg-1831
#2
Ramachandran Karthik, Venkatesan Manigandan, Kumar Ebenezar, Raghavan Vijayashree, Ramachandran Saravanan
The data presented illustrated the in vitro anti-proliferative effect of the PSG toxin from the cuttlefish, Sepia pharaonis. The cytostatic potentials of the PSG toxin were determined by the lymphocyte migration inhibition assay. The PSG toxin (50 μg/ml) exhibited commendable inhibition of the migration of lymphocytes across the agarose gel matrix under the presence of lipopolysaccharide mitogen, with a mean migration index of 0.625. The cytotoxicity of the PSG toxin against selected cancer cell lines was determined using the MTT assay...
August 2017: Data in Brief
https://www.readbyqxmd.com/read/28640094/effects-of-first-radioiodine-ablation-on-functions-of-salivary-glands-in-patients-with-differentiated-thyroid-cancer
#3
Arun Upadhyaya, Zhaowei Meng, Peng Wang, Guizhi Zhang, Qiang Jia, Jian Tan, Xue Li, Tianpeng Hu, Na Liu, Pingping Zhou, Sen Wang, Xiaoxia Liu, Huiying Wang, Chunmei Zhang, Fengxiao Zhao, Ziyu Yan
The aim of this study was to evaluate the effects of the first radioactive iodine (I) therapy on functions of salivary glands in patients with differentiated thyroid carcinoma (DTC).There were 36 consented patients with DTC enrolled in this study, who received 3.7 GBq (100mCi) I for ablation after total thyroidectomy. Salivary gland function was assessed using salivary gland scintigraphy in two phases, one 4 hours before and the other 6 months after I therapy (both under thyrotropin stimulation condition)...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28637715/tyrosine-kinase-inhibitors-protect-the-salivary-gland-from-radiation-damage-by-inhibiting-activation-of-protein-kinase-c-%C3%AE
#4
Sten M Wie, Elizabeth Wellberg, Sana D Karam, Mary E Reyland
In patients undergoing irradiation therapy, injury to non-tumor tissues can result in debilitating, and sometimes permanent, side effects. We have defined Protein Kinase C-delta (PKCδ) as a regulator of DNA damage induced apoptosis and have shown that phosphorylation of PKCδ by c-Abl and c-Src activates its pro-apoptotic function.  Here we have explored the use of tyrosine kinase inhibitors (TKIs) of c-Src and c-Abl to block activation of PKCδ for radioprotection of the salivary gland.  Dasatinib, imatinib, and bosutinib all suppressed tyrosine phosphorylation of PKCδ and inhibited IR-induced apoptosis in vitro  To determine if TKIs can provide radioprotection of salivary gland function in vivo, mice were treated with TKIs and a single or fractionated doses of irradiation...
June 21, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28636292/-head-and-neck-cancer-promising-results-of-immunotherapy
#5
Aurélie Sivade, Djamila Bensaid, Yan Monnier, Keyvan Shabafrouz, Hanan Bouchaab, Valérie Cristina
Immunotherapy, especially checkpoint inhibitors such as anti-PD1 and anti-PDL1 antibodies, has changed the standard of care and the prognosis of melanoma, but also more recently of lung cancer, renal cancer and Hodgkin lymphoma. Results of preliminary studies in head and neck squamous cell carcinoma (HNSCC) as well as in less frequent tumors of the region, such as nasopharyngeal carcinoma and high grade salivary gland carcinoma, are also promising. Indeed, in a recent phase 3 study, the PD1 inhibitor nivolumab has recently demonstrated a significant improvement in overall survival for platin-resistant recurrent and/or metastatic HNSCC...
May 17, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28631560/mithramycin-inhibits-epithelial-to-mesenchymal-transition-and-invasion-by-downregulating-sp1-and-snai1-in-salivary-adenoid-cystic-carcinoma
#6
Jiasu Li, Hongmei Gao, Lingxu Meng, Lin Yin
Mithramycin exhibits certain anticancer effects in glioma, metastatic cerebral carcinoma, malignant lymphoma, chorionic carcinoma and breast cancer. However, its effects on salivary adenoid cystic carcinoma remain unclear. Here, we report that mithramycin significantly inhibited epithelial-to-mesenchymal transition and invasion in human salivary adenoid cystic carcinoma cell lines. The underlying mechanism for this activity was further demonstrated to involve decreasing the expression of the transcription factors specificity protein 1 and SNAI1...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28628803/mucoepidermoid-carcinoma-associated-expression-of-muc5ac-muc5b-and-mucin-type-carbohydrate-antigen-sialyl-tn-in-the-parotid-gland
#7
Johannes H Matse, Wiresh K Bharos, Enno C I Veerman, Elisabeth Bloemena, Jan G M Bolscher
OBJECTIVES: The aberrant expression of mucins and mucin-type carbohydrates has been described in many types of cancer, including mucoepidermoid carcinoma (MEC), a malignant salivary gland tumor. In this study, we examined the aberrant expression patterns of mucins (MUC1, MUC4, MUC5AC and MUC5B), simple mucin-type carbohydrate antigens (Tn, sialyl-Tn and T) and mature carbohydrate antigens (Lewis(a) and sulfo-Lewis(a) antigens) in MEC originating from the parotid gland, which normally does not secrete mucins...
June 13, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28625410/sialadenoma-papilliferum-in-the-buccal-mucosa-detected-on-18-f-fluorodeoxyglucose-positron-emission-tomography
#8
S Miyamoto, T Ogawa, D Chikazu
An incidental discovery of an accumulation of (18)F-fluorodeoxyglucose (FDG) in the oral cavity of patients with malignant tumours on FDG positron emission tomography (PET) can pose a problem regarding the differential diagnosis of metastatic lesions. Large accumulations can often be found even when tumours in the salivary or thyroid gland are benign, so FDG-PET is limited in its ability to differentiate between benign and malignant disease. This report describes a rare case of sialadenoma papilliferum in the buccal mucosa that was discovered incidentally on FDG-PET in a patient with multiple metastases to bone after an operation for rectal cancer...
June 15, 2017: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/28623401/biomarkers-in-the-assessment-of-oral-mucositis-in-head-and-neck-cancer-patients-a-systematic-review-and-meta-analysis
#9
REVIEW
Ana Gabriela Costa Normando, Camila Lopes Rocha, Isabela Porto de Toledo, Paulo Tadeu de Souza Figueiredo, Paula Elaine Diniz Dos Reis, Graziela De Luca Canto, Eliete Neves Silva Guerra
PURPOSE: The aim of this study was to evaluate the capability of biomarkers to predict the risk of oral mucositis in head and neck cancer patients, as well as to assess the correlation between these biomarkers and the severity of mucositis. METHODS: The search was performed at LILACS, PubMed, Science Direct, Scopus, and Web of Science. A search of the gray literature was performed on Google Scholar, OpenGrey, and ProQuest. The methodological quality of the included studies was assessed using the Meta-Analysis of Statistics Assessment and Review Instrument (MAStARI) tool, and the evidence quality was assessed by the Grading of Recommendation, Assessment, Development, and Evaluation (GRADE) system...
June 16, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28614209/newly-described-entities-in-salivary-gland-pathology
#10
Alena Skálová, Douglas R Gnepp, James S Lewis, Jennifer L Hunt, Justin A Bishop, Henrik Hellquist, Alessandra Rinaldo, Vincent Vander Poorten, Alfio Ferlito
Salivary glands may give rise to a wide spectrum of different tumors. This review concentrates on 4 salivary gland tumors that have been accepted in the recent literature as new neoplastic entities: mammary analog secretory carcinoma, cribriform adenocarcinoma of minor salivary glands (CASG), sclerosing polycystic adenosis/adenoma (SPA), and the mucinous/secretory variant of myoepithelioma. Mammary analog secretory carcinoma is a distinctive low-grade malignant salivary cancer that harbors a characteristic chromosomal translocation, t(12;15) (p13;q25), resulting in an ETV6-NTRK3 fusion...
June 13, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28610404/effects-of-tobacco-on-salivary-antioxidative-and-immunologic-systems
#11
Fateme Arbabi-Kalati, Saeede Salimi, Saeede Nabavi, Sahebdad Rigi, Masoud Miri-Moghaddam
Background: Tobacco use is a harmful habit that causes adverse effects on oral health and plays a most important role in cancer development. Saliva is the first fluid that is exposed to tobacco and its antioxidant system plays an important role in anti-cancer potential; therefore, this study was designed to compare the antioxidant activity and immunologic system of saliva in tobacco users (smokers and smokeless tobacco users) and non-users. Materials and Methods: In this cross-sectional study, unstimulated saliva samples of 75 healthy individuals from three equal groups were investigated...
May 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28596498/somatic-mutations-in-salivary-duct-carcinoma-and-potential-therapeutic-targets
#12
Timothy K Khoo, Bing Yu, Joel A Smith, Angus J Clarke, Peter P Luk, Christina I Selinger, Kate L Mahon, Spiridoula Kraitsek, Carsten Palme, Michael J Boyer, Marcel E Dinger, Mark J Cowley, Sandra A O'Toole, Jonathan R Clark, Ruta Gupta
BACKGROUND: Salivary duct carcinomas (SDCa) are rare highly aggressive malignancies. Most patients die from distant metastatic disease within three years of diagnosis. There are limited therapeutic options for disseminated disease. RESULTS: 11 cases showed androgen receptor expression and 6 cases showed HER2 amplification. 6 Somatic mutations with additional available targeted therapies were identified: EGFR (p.G721A: Gefitinib), PDGFRA (p.H845Y: Imatinib and Crenolanib), PIK3CA (p...
May 25, 2017: Oncotarget
https://www.readbyqxmd.com/read/28596256/nccn-guidelines-insights-head-and-neck-cancers-version-2-2017
#13
David Adelstein, Maura L Gillison, David G Pfister, Sharon Spencer, Douglas Adkins, David M Brizel, Barbara Burtness, Paul M Busse, Jimmy J Caudell, Anthony J Cmelak, A Dimitrios Colevas, David W Eisele, Moon Fenton, Robert L Foote, Jill Gilbert, Robert I Haddad, Wesley L Hicks, Ying J Hitchcock, Antonio Jimeno, Debra Leizman, William M Lydiatt, Ellie Maghami, Loren K Mell, Bharat B Mittal, Harlan A Pinto, John A Ridge, James Rocco, Cristina P Rodriguez, Jatin P Shah, Randal S Weber, Matthew Witek, Frank Worden, Sue S Yom, Weining Zhen, Jennifer L Burns, Susan D Darlow
The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Head and Neck Cancers provide treatment recommendations for cancers of the lip, oral cavity, pharynx, larynx, ethmoid and maxillary sinuses, and salivary glands. Recommendations are also provided for occult primary of the head and neck (H&N), and separate algorithms have been developed by the panel for very advanced H&N cancers. These NCCN Guidelines Insights summarize the panel's discussion and most recent recommendations regarding the increase in human papillomavirus-associated oropharyngeal cancer and the availability of immunotherapy agents for treatment of patients with recurrent or metastatic H&N cancer...
June 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/28589107/head-and-neck-cancers-in-north-east-iran-a-25-year-survey
#14
Maryam Emadzadeh, Soodabeh Shahidsales, Amirhossein Mohammadian Bajgiran, Mahta Salehi, Toktam Massoudi, Zahra Nikfarjam, Maryam Salehi
INTRODUCTION: Cancers are among the worst noncommunicable diseases around the world. Head and neck cancers are ranked as the fifth most common cancers worldwide. As there are different distributions of risk factors around the world, the incidence of these cancers varies from one place to another. MATERIALS AND METHODS: We conducted a descriptive analytic cross-sectional study, based on census-based records from the private oncology clinic in Mashhad, Iran. Data from 1,075 patients with head and neck cancers were analyzed from 1986 to 2010...
May 2017: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28588084/highlight-understanding-radiation-sialadenitis
#15
Michael B Yaffe
A nonapoptotic function of caspase-3 underlies the salivary gland complications of radiation therapy of head and neck cancers.
June 6, 2017: Science Signaling
https://www.readbyqxmd.com/read/28588083/science-signaling-podcast-for-6-june-2017-calcium-signaling-and-dry-mouth
#16
Indu Ambudkar, Annalisa M VanHook
This Podcast features a conversation with Indu Ambudkar, senior author of a Research Resource that appears in the 6 June 2017 issue of Science Signaling, about how activation of the cation channel TRPM2 is involved in radiation-induced dry mouth. Patients who receive radiation therapy for head and neck cancers often develop dry mouth as a side effect, and this condition is frequently permanent. Radiation does not kill cells in the salivary gland, yet it causes the acinar cells of the gland to reduce the amount of saliva they secrete...
June 6, 2017: Science Signaling
https://www.readbyqxmd.com/read/28579265/importance-of-chewing-saliva-and-swallowing-function-in-patients-with-advanced-oral-cancer-undergoing-preoperative-chemoradiotherapy-a-prospective-study-of-quality-of-life
#17
D Nemeth, L Zaleczna, A Huremovic, J Engelmann, P W Poeschl, M Strasz, S Holawe, G Kornek, A Laskus, C Sacher, B M Erovic, C Perisanidis
The primary objective of this study was to investigate the quality of life (QOL) of patients with oral squamous cell carcinoma (OSCC) undergoing curative neoadjuvant chemoradiotherapy followed by radical tumour resection and simultaneous oral cavity reconstruction, using two validated questionnaires. A secondary objective was to assess clinical variables predicting post-treatment dysfunction in chewing, saliva, and swallowing. Thirty-five patients with locally advanced OSCC who underwent preoperative chemoradiotherapy were recruited prospectively...
June 1, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28575794/-99m-tc-labeled-psma-inhibitor-biokinetics-and-radiation-dosimetry-in-healthy-subjects-and-imaging-of-prostate-cancer-tumors-in-patients
#18
Clara Santos-Cuevas, Jenny Davanzo, Guillermina Ferro-Flores, Francisco O García-Pérez, Blanca Ocampo-García, Eleazar Ignacio-Alvarez, Edgar Gómez-Argumosa, Martha Pedraza-López
The prostate-specific membrane antigen (PSMA) is expressed in epithelial cells of the prostate and highly overexpressed in 95% of advanced prostate cancers. The aims of this study was to estimate the biokinetics and dosimetry of (99m)Tc-EDDA/HYNIC-iPSMA ((99m)Tc-labeled PSMA inhibitor) in eight healthy subjects and evaluate its usefulness as a tumor-imaging agent in eight prostate cancer patients. METHODS: (99m)Tc-EDDA/HYNIC-iPSMA was obtained from a lyophilized formulation with radiochemical purities >98%, determined by reversed-phase HPLC and ITLC-SG analyses...
May 25, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28557276/evolving-trends-in-head-and-neck-cancer-epidemiology-ontario-canada-1993-2010
#19
Matthew Mifsud, Antoine Eskander, Jonathan Irish, Patrick Gullane, Ralph Gilbert, Dale Brown, John R de Almeida, David R Urbach, David P Goldstein
BACKGROUND: Given the dramatic changes in global head and neck cancer epidemiology, the purpose of this study was to present the findings of our investigation on patterns of head and neck cancer incidence/survival within the province of Ontario, Canada. METHODS: Temporal variations in age/sex adjusted incidence and survival were analyzed for all incident head and neck cancer cases (n = 20 781) managed within Ontario from 1993-2010. RESULTS: From 1993-2010, the incidence of oropharyngeal (average annual percentage change [AAPC] 4...
May 30, 2017: Head & Neck
https://www.readbyqxmd.com/read/28551337/margin-analysis-malignant-salivary-gland-neoplasms-of-the-head-and-neck
#20
REVIEW
Robert A Ord, Naseem Ghazali
There are no established protocols for the optimum surgical margin required for salivary gland malignancies. Factors including histologic diagnosis and TNM stage have been shown to be important in prognosis and survival outcome and mandate special consideration of margin size. Salivary cancers are treated differently at different anatomic sites and different histologic types show a propensity for major or minor glands. Low-grade malignancies are treated with soft tissue margins of 1 cm or less. The facial nerve is preserved unless infiltrated and encased...
May 24, 2017: Oral and Maxillofacial Surgery Clinics of North America
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