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https://www.readbyqxmd.com/read/29449729/parotid-metastasis-of-renal-cell-carcinoma-mimicking-primary-clear-cell-oncocytoma-report-of-a-case-and-brief-review-of-the-literature
#1
B J Rocca, A Gini, C Calandra, A Ginori, F Crivelli
Malignancies of the parotid gland are relatively uncommon, accounting for only 3-6% of all head and neck cancers. Most of them are primary neoplasms, metastases are uncommon. Renal cell carcinoma (RCC) represents 3% of adult malignancies, the clear cell type comprises up to 70% of all RCC. RCC has an unpredictable behavior and the unique potential to metastasize to nearly every organ in the body. Though not as frequent, metastatic RCC to the head and neck has been identified in the thyroid, salivary glands, skull base, sinuses, pharynx, tonsils, tongue, lip and skin...
December 2017: Pathologica
https://www.readbyqxmd.com/read/29449591/familial-risks-between-urolithiasis-and-cancer
#2
Kari Hemminki, Otto Hemminki, Asta Försti, Jan Sundquist, Kristina Sundquist, Xinjun Li
Urolithiasis (UL, urinary tract stone disease) has been reported to increase subsequent cancers in the urinary tract. Recently, we showed data that surveillance bias may be an important confounder in the reported associations. In the present approach we want to address the question of possible cancer risk posed by UL mechanistically. Both UL and cancer have strong genetic components and we hypothesize that familial association between UL and cancer may be plausible. We thus assess familial risks between UL and cancer, hoping to find an explanation why UL may pose a risk of cancer...
February 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29447885/pediatric-head-and-neck-squamous-cell-carcinoma-patient-demographics-treatment-trends-and-outcomes
#3
Ankit Modh, Omar H Gayar, Mohamed A Elshaikh, Arnold C Paulino, Farzan Siddiqui
OBJECTIVES: To examine patient demographics, temporal and treatment trends, and survival outcomes of pediatric non-nasopharyngeal head and neck squamous cell carcinomas using the National Cancer Database. METHODS: The National Cancer Database was queried for pediatric patients (age 0-19 years) diagnosed with squamous cell carcinoma of the head and neck (including oral cavity, oropharynx, nasal cavity, larynx, hypopharynx, and salivary glands) from 2004 to 2013. RESULTS: Of 159 patients identified, the majority had oral cavity SCC (55%)...
March 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29445858/l-thyroxine-intake-as-a-potential-risk-factor-for-the-development-of-fatigue-in-breast-cancer-patients-undergoing-chemotherapy
#4
Martina E Schmidt, Joachim Wiskemann, Theron Johnson, Nina Habermann, Andreas Schneeweiss, Karen Steindorf
PURPOSE: L-Thyroxine is one of the most commonly prescribed drugs and accordingly used by many breast cancer patients with thyroid disorders. Hence, potential interactions of chemotherapy with L-thyroxine, possibly contributing to fatigue, would be of high clinical relevance. Therefore, we investigated fatigue and underlying pathways in L-thyroxine-using breast cancer patients during chemotherapy. METHODS: Thyroid-stimulating hormone (TSH), L-triiodothyronine (T3), and diurnal salivary cortisol patterns were analyzed in breast cancer patients in the beginning and at the end of adjuvant chemotherapy within the control group (n = 41) of a randomized exercise intervention trial...
February 14, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29443033/a-method-for-the-measurement-of-salivary-gland-function-in-mice
#5
Harini Bagavant, Marta Trzeciak, Joanna Papinska, Indranil Biswas, Micah L Dunkleberger, Anna Sosnowska, Umesh S Deshmukh
Patients with Sjögren's syndrome, an autoimmune disease affecting the exocrine glands, develop salivary gland inflammation and have reduced saliva production. Similarly, saliva production is severely compromised in patients receiving radiation treatment for head and neck cancers. Rodent models, developed to mimic these clinical conditions, facilitate an understanding of the disease pathogenesis and allow for the development of new therapeutic strategies. Therefore, the ability to accurately, reproducibly, and repeatedly measure salivary gland function in animal models is critical...
January 25, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29441100/dose-volume-analysis-of-target-volume-and-critical-structures-in-computed-tomography-image-based-multicatheter-high-dose-rate-interstitial-brachytherapy-for-head-and-neck-cancer
#6
Hironori Akiyama, Tibor Major, Csaba Polgár, Zoltán Takácsi-Nagy
Purpose: To evaluate dose-volume relationships of target volume and critical structures in computed tomography (CT) image-based brachytherapy for head and neck cancer. Material and methods: Thirty-seven patients with mobile tongue, floor of mouth, and base of tongue cancer treated with brachytherapy (post-operative alone and as a boost after external beam radiotherapy [EBRT], or definitive alone or as a boost after EBRT) were selected. Treatment plans were made using post-implant CT images...
December 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/29439690/a-systematic-review-of-the-effects-of-acupuncture-on-xerostomia-and-hyposalivation
#7
Zainab Assy, Henk S Brand
BACKGROUND: Saliva is fundamental to our oral health and our well-being. Many factors can impair saliva secretion, such as adverse effects of prescribed medication, auto-immune diseases (for example Sjögren's syndrome) and radiotherapy for head and neck cancers. Several studies have suggested a positive effect of acupuncture on oral dryness. METHODS: Pubmed and Web of Science were electronically searched. Reference lists of the included studies and relevant reviews were manually searched...
February 13, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29436307/cancers-of-the-major-salivary-gland
#8
Eugene Son, Aru Panwar, Charles H Mosher, Daniel Lydiatt
Salivary gland malignancies are rare tumors that comprise multiple histologic entities with diverse clinical behavior. Mucoepidermoid carcinoma is the most frequent primary salivary malignancy, followed by adenoid cystic and acinic cell carcinoma. Although most salivary malignancies are asymptomatic, presentation with a rapidly enlarging mass may be accompanied by pain, functional neurologic deficits, soft-tissue invasion, or nodal enlargement. Assessment of clinical behavior and physical exam greatly contributes to diagnostic workup...
February 2018: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29436304/challenges-and-opportunities-for-developing-new-therapeutics-for-salivary-gland-cancers
#9
Alan L Ho, David G Pfister
No abstract text is available yet for this article.
February 2018: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29435836/oral-and-dental-health-in-head-and-neck-cancer-patients
#10
Joel B Epstein, Andrei Barasch
A diagnosis of head and neck cancer (HNC) is typically followed by therapy that is associated with immediate and long-lasting toxic consequences. HNC patients' oral health needs may be complex and are best addressed in multidisciplinary collaborative teams including surgical, medical, and radiation oncologists, dental providers, nutrition, speech/swallow specialists, and physical therapists. Oral health maintenance also requires patient compliance and caregiver support. The role of dental providers begins prior to cancer diagnosis and continues through survivorship...
2018: Cancer Treatment and Research
https://www.readbyqxmd.com/read/29431239/significance-of-blood-and-salivary-iex-1-expression-in-diagnosis-of-epithelial-ovarian-carcinoma
#11
Yuan Li, Chaoyue Tan, Liya Liu, Liping Han
AIM: This study assesses a clinical potential of immediate early responsive gene X-1 (IEX-1), also named IER3, in the diagnosis of epithelial ovarian carcinoma using blood and salivary specimens. METHODS: Immediate early responsive gene X-1 was quantified in blood and saliva by real-time quantitative reverse transcription polymerase chain reaction in 26 cases of epithelial ovarian carcinoma, 37 cases of benign ovarian tumor and 55 cases of healthy women. The receiver operating characteristic (ROC) curve was used to evaluate the diagnostic efficacy of IEX-1...
February 12, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29425763/buccal-drug-delivery-technologies-for-patient-centred-treatment-of-radiation-induced-xerostomia-dry-mouth
#12
REVIEW
Osamah S Malallah, Cristina M Aller Garcia, Gordon B Proctor, Ben Forbes, Paul G Royall
Radiotherapy is a life-saving treatment for head and neck cancers, but almost 100% of patients develop dry mouth (xerostomia) because of radiation-induced damage to their salivary glands. Patients with xerostomia suffer symptoms that severely affect their health as well as physical, social and emotional aspects of their life. The current management of xerostomia is the application of saliva substitutes or systemic delivery of saliva-stimulating cholinergic agents, including pilocarpine, cevimeline or bethanechol tablets...
February 6, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29424489/hsp27-associates-with-epithelial-mesenchymal-transition-stemness-and-radioresistance-of-salivary-adenoid-cystic-carcinoma
#13
Wei Chen, Xiaohua Ren, Jiashun Wu, Xiaolei Gao, Xiao Cen, Shasha Wang, Surui Sheng, Qianming Chen, Ya-Jie Tang, Xin-Hua Liang, Ya-Ling Tang
Epithelial-mesenchymal transition (EMT) has been shown to associate with cancer stem cells and radioresistance. However, it is obscure whether EMT itself or specific EMT regulators play causal roles in these properties of salivary adenoid cystic carcinoma (SACC). Here, we exhibited that overexpression of HSP27 drove the migration and invasion, induced EMT, as well as mediated TGF-β1-induced EMT in SACC cells, accompanying the up-regulation of Snail1 and Prrx1. Conversely, HSP27 silencing reduced the migration and invasion and contributed to MET of SACC cells...
February 9, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29419479/the-effect-of-total-tumor-volume-on-the-biologically-effective-dose-of-tumor-and-kidneys-for-177lu-labelled-psma-peptides
#14
Nusrat Begum, Anne Thieme, Nina Eberhardt, Robert Tauber, Ambros J Beer, Gerhard Glatting, Matthias Eiber, Peter Kletting
Aim: To simulate the effect of PSMA positive total tumor volume (TTV) on the tumor and organs at risk (OARs) biologically effective doses (BEDs) in patients with metastatic castration resistant prostate cancer (mCRPC) in 177Lu-PSMA radioligand therapy. Methods: A physiologically-based pharmacokinetic model was fitted to data of 13 patients treated with 177Lu-PSMA I&T. The tumor, kidneys and salivary glands BEDs were simulated for TTVs of 0.1-10 l. The activity and peptide amounts leading to an optimal tumor-to-kidneys BED ratio were also investigated...
February 1, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29419396/expanding-primary-cells-from-mucoepidermoid-and-other-salivary-gland-neoplasms-for-genetic-and-chemosensitivity-testing
#15
Ahmad M Alamri, Xuefeng Liu, Jan K Blancato, Bassem R Haddad, Weisheng Wang, Xiaogang Zhong, Sujata Choudhary, Ewa Krawczyk, Bhaskar V Kallakury, Bruce J Davidson, Priscilla A Furth
Restricted availability of cell and animal models is a rate-limiting step for investigation of salivary gland neoplasm pathophysiology and therapeutic response. Conditionally reprogrammed cell (CRC) technology enables establishment of primary epithelial cell cultures from patient material. This study tested a translational workflow for acquisition, expansion and testing of CRC-derived primary cultures of salivary gland neoplasms from patients presenting to an academic surgical practice. Results showed that cultured cells were sufficient for epithelial cell-specific transcriptome characterization to detect candidate therapeutic pathways and fusion genes, and for screening for cancer risk-associated single nucleotide polymorphisms (SNPs) and driver gene mutations through exome sequencing...
January 29, 2018: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29415170/developing-androgen-receptor-targeting-for-salivary-gland-cancers
#16
A L Ho
No abstract text is available yet for this article.
February 5, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29412371/trend-of-oral-and-pharyngeal-cancer-mortality-in-brazil-in-the-period-of-2002-to-2013
#17
Lillia Magali Estrada Perea, Marco Aurélio Peres, Antonio Fernando Boing, José Leopoldo Ferreira Antunes
OBJECTIVE: To analyze the trend of oral and pharyngeal cancer mortality rates in the period of 2002 to 2013 in Brazil according to sex, anatomical site, and macroregion of the country. METHODS: The mortality data were obtained from the Mortality Information System and the population data were obtained from the Brazilian Institute of Geography and Statistics. The trend of the rates standardized by sex and age was calculated using the Prais-Winsten estimation, and we obtained the annual percentage change and the respective 95% confidence intervals, analyzed according to sex, macroregion, and anatomical site...
February 5, 2018: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29409471/pd-l1-expression-in-malignant-salivary-gland-tumors
#18
Koji Harada, Tarannum Ferdous, Yoshiya Ueyama
BACKGROUND: Programmed death-1 ligand-1 (PD-L1) an important cancer biomarker that can suppress the immune system and its high expression is often reported to be related with increased tumor aggressiveness in some cancers. Here, we examined and evaluated PD-L1 expression in patients with malignant salivary gland tumor. Moreover, the relationship between PD-L1 immunolocalization and clinical pathological features, as well as the prognosis of malignant salivary gland tumors was investigated...
February 6, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29406257/high-expression-of-prospero-related-homeobox-1-prox1-is-associated-with-poor-prognosis-in-patients-with-salivary-adenoid-cystic-carcinoma
#19
Tao Gao, Chao Ma, Yun Li, Jun Ju, Xiangfeng Kang, Yuanlin Cai, Moyi Sun
PURPOSE: Prospero-related homeobox-1 (PROX1) plays an important role in the invasion and metastasis of many human cancers. However, the expression pattern of PROX1 in salivary adenoid cystic carcinoma (SACC) remains unclear. The aim of this study was to investigate PROX1 expression and its prognostic value in SACC. MATERIALS AND METHODS: PROX1 expression was determined by immunohistochemistry (IHC) in SACC tissue specimens. Correlations between PROX1 expression and clinicopathologic features were investigated...
January 11, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29402727/salivary-glycopatterns-as-potential-biomarkers-for-screening-of-early-stage-breast-cancer
#20
Xiawei Liu, Hanjie Yu, Yan Qiao, Jiajun Yang, Jian Shu, Jiaxu Zhang, Zhiwei Zhang, Jianjun He, Zheng Li
OBJECTIVE: We systematically investigated and assessed the alterations of salivary glycopatterns and possibility as biomarkers for diagnosis of early-stage breast cancer. DESIGN: Alterations of salivary glycopatterns were probed using lectin microarrays and blotting analysis from 337 patients with breast benign cyst or tumor (BB) or breast cancer (I/II stage) and 110 healthy humans. Their diagnostic models were constructed by a logistic stepwise regression in the retrospective cohort...
February 2, 2018: EBioMedicine
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