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Salivary cancer

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https://www.readbyqxmd.com/read/28346649/the-rising-incidence-of-major-salivary-gland-cancer-in-the-united-states
#1
Anthony G Del Signore, Uchechukwu C Megwalu
We performed a population-based historical cohort study using the Surveillance, Epidemiology, and End Results (SEER) database to determine trends in the incidence of major salivary gland cancer and to evaluate the effect of sex, tumor size, histology, primary site, and extent of disease. Participants were men and women with major salivary gland cancer, diagnosed 1973-2009. The incidence of major salivary gland cancer increased from 10.4 per 1,000,000 in 1973 to 16 per 1,000,000 in 2009 (annual percent change [APC] 0...
March 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28343305/clinicopathologic-and-genetic-features-of-primary-bronchopulmonary-mucoepidermoid-carcinoma-the-md-anderson-cancer-center-experience-and-comprehensive-review-of-the-literature
#2
Alireza Salem, Diana Bell, Boris Sepesi, Vassiliki Papadimitrakopoulou, Adel El-Naggar, Cesar A Moran, Neda Kalhor
Primary bronchopulmonary mucoepidermoid carcinoma (BPMEC) is a rare tumor. The fusion protein MECT1-MAML2 has been implicated as a causative genetic event in salivary and BPMECs. Several studies have shown the impact of MECT1-MAML2 on the diagnosis and prognosis of salivary gland mucoepidermoid carcinoma; however, few studies have been published regarding MECT1-MAML2 in the context of primary BPMEC. We describe the clinicopathologic, genetic, and outcome data of 16 patients with BPMEC. Clinicopathologic features were recorded from the electronic medical records...
March 25, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28341276/lung-metastasectomy-in-adenoid-cystic-cancer-is-it-worth-it
#3
Lara Girelli, Laura Locati, Carlotta Galeone, Paolo Scanagatta, Leonardo Duranti, Lisa Licitra, Ugo Pastorino
BACKGROUND AND PURPOSE: Adenoid cystic carcinoma (ACC) of salivary glands is characterized by long-term distant metastasis, most commonly in lungs. No agreement has been reached about the role of surgical treatment of pulmonary lesions. We evaluated the long-term results of lung metastasectomy for ACC in order to identify factors that should be taken into account in selecting patients eligible for surgery and treatment planning. PATIENTS AND METHODS: A retrospective study was conducted on 109 patients selected from our institutional experience and from the International Registry of Lung Metastases...
February 2017: Oral Oncology
https://www.readbyqxmd.com/read/28337279/agr2-promotes-the-proliferation-migration-and-regulates-epithelial-mesenchymal-transition-in-salivary-adenoid-cystic-carcinoma
#4
Si-Rui Ma, Liang Mao, Wei-Wei Deng, Yi-Cun Li, Lin-Lin Bu, Guang-Tao Yu, Wen-Feng Zhang, Zhi-Jun Sun
Salivary adenoid cystic carcinoma (AdCC) is a common head and neck cancer with the propensity for local spread and distant metastasis. In our previous study, elevated expression of Anterior gradient 2 (AGR2) was detected in head and neck squamous cell carcinoma (HNSCC), associated with epithelial-mesenchymal transition (EMT) and cancer stemness. However, to date, the expression and function of AGR2 in AdCC has yet to be elucidated. In the present study, human AdCC tissue microarrays including 18 cases of normal salivary gland (NSG), 12 cases of pleomorphic adenoma (PMA) and 72 cases of AdCC were employed for immunohistochemical staining analysis...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28336186/variation-in-head-and-neck-cancer-care-in-the-netherlands-a-retrospective-cohort-evaluation-of-incidence-treatment-and-outcome
#5
M de Ridder, A J M Balm, R J Baatenburg de Jong, C H J Terhaard, R P Takes, M Slingerland, E Dik, R J E Sedee, J G A M de Visscher, H Bouman, S M Willems, M W Wouters, L E Smeele, B A C van Dijk
BACKGROUND: To explore variation in numbers and treatment between hospitals that treat head and neck cancer (HNC) in the Netherlands. MATERIAL AND METHODS: Patient, tumor and treatment characteristics were collected from the Netherlands Cancer Registry, while histopathological features were obtained by linkage to the national pathology record register PALGA. Inter-hospital variation in volume, stage, treatment, pathologically confirmed loco-regional recurrence and overall survival rate was evaluated by tumor site...
March 8, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28327999/comprehensive-genomic-profiling-of-salivary-mucoepidermoid-carcinomas-reveals-frequent-bap1-pik3ca-and-other-actionable-genomic-alterations
#6
K Wang, J D McDermott, A B Schrock, J A Elvin, L Gay, S D Karam, D Raben, H Somerset, S M Ali, J S Ross, D W Bowles
Background: We sought to identify genomic alterations (GAs) in salivary mucoepidermoid carcinomas. Patients and methods: DNA was extracted from 48 mucoepidermoid carcinomas. Comprehensive genomic profiling (CGP) including the calculation to tumor mutational burden (TMB) was performed on hybridization-captured adaptor ligation-based libraries of 315 cancer-related genes plus introns from 28 genes frequently rearranged for cancer and evaluated for all classes of GAs...
January 16, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28325631/new-concepts-of-personalized-therapy-in-salivary-gland-carcinomas
#7
REVIEW
Gunter Keller, Diana Steinmann, Alexander Quaas, Viktor Grünwald, Stefan Janssen, Kais Hussein
Salivary gland carcinomas are rare tumours and therapy strategies are less standardized than in lung, gastric or breast cancer. Therapy is based on surgery, but not all carcinomas are completely resectable, e.g. because carcinomas often show infiltration of nerves. For further therapy decision pathology is recommended, but evaluation of potential targets for personalized therapy is not part of the routine panel. Many salivary gland carcinomas can be resistant to radio- and/or chemotherapy, which limits therapeutic options...
March 18, 2017: Oral Oncology
https://www.readbyqxmd.com/read/28323577/mitigation-of-radiation-induced-epithelial-damage-by-the-tlr5-agonist-entolimod-in-a-mouse-model-of-fractionated-head-and-neck-irradiation
#8
Ilia A Toshkov, Anatoli S Gleiberman, Vadim L Mett, Alan D Hutson, Anurag K Singh, Andrei V Gudkov, Lyudmila G Burdelya
Radiation treatment of head and neck cancer frequently causes severe collateral damage to normal tissues including mouth mucosa, salivary glands and skin. This toxicity limits the radiation dose that can be delivered and affects the patient's quality of life. Previous studies in mice and nonhuman primates showed that entolimod, a toll-like receptor 5 (TLR5) agonist derived from bacterial flagellin, effectively reduced radiation damage to hematopoietic and gastrointestinal tissues in both total-body and local irradiation scenarios, with no protection of tumors...
March 21, 2017: Radiation Research
https://www.readbyqxmd.com/read/28321773/salivary-duct-carcinoma-an-update-on-morphologic-mimics-and-diagnostic-use-of-androgen-receptor-immunohistochemistry
#9
Aaron M Udager, Simion I Chiosea
More than 15 years ago, seminal studies by Dr. E. Leon Barnes and colleagues transformed our understanding of salivary duct carcinoma (SDC) and, in doing so, paved the way for contemporary diagnostic and therapeutic approaches to this aggressive salivary adenocarcinoma. In particular, attention to the apocrine phenotype of SDC and expression of androgen receptor (AR) by immunohistochemistry has improved the diagnostic accuracy and showed how SDC can be reliably distinguished from its morphologic mimics (i.e...
March 20, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28319898/immunodetection-of-salivary-biomarkers-by-an-optical-microfluidic-biosensor-with-polyethylenimine-modified-polythiophene-c70-organic-photodetectors
#10
Tao Dong, Nuno Miguel Matos Pires
This work reports a novel optical microfluidic biosensor with highly sensitive organic photodetectors (OPDs) for absorbance-based detection of salivary protein biomarkers at the point of care. The compact and miniaturized biosensor has comprised OPDs made of polythiophene-C70 bulk heterojunction for the photoactive layer; whilst a calcium-free cathode interfacial layer, made of linear polyethylenimine, was incorporated to the photodetectors to enhance the low cost. The OPDs realized onto a glass chip were aligned to antibody-functionalized chambers of a poly(methyl methacrylate) microfluidic chip, in where immunogold-silver assays were conducted...
March 6, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28318170/-application-of-saliva-in-disease-diagnosis
#11
Cheng Xingqun, Zhou Xuedong, Xu Xin
Saliva is secreted by salivary glands and performs a variety of functions, including mouth cleaning and protection, antibacterial activity, and digestion. With the rapid progress in salivaomics, saliva became recognized as a potential pool of biological markers. Being a non-invasive and safe source, saliva is a potential substitute for blood in diagnosis and prognosis of diseases. This review summarizes the latest advancement in saliva-related studies and presents the potential value of saliva in early diagnosis of oral diseases, such as dental caries, periodontal disease, cancer, diabetes, and other systemic disorders...
December 1, 2016: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28315910/effect-of-selenium-supplementation-for-protection-of-salivary-glands-from-iodine-131-radiation-damage-in-patients-with-differentiated-thyroid-cancer
#12
Haiyoung Son, Sang Mi Lee, Ra Gyoung Yoon, Hakmin Lee, Ilkyun Lee, Soon Kim, Woong Youn Chung, Jeong Won Lee
OBJECTIVE: In the current study, we examined whether selenium supplementation during iodine-131 ((131)I) treatment had a radio-protective effect on salivary glands. SUBJECTS AND METHODS: Sixteen patients with differentiated thyroid cancer were prospectively enrolled in the study. Patients after total thyroidectomy, before (131)I treatment, were divided into two groups; 8 patients in the selenium group and 8 patients in the control group. Patients in the selenium group received 300νg of selenium orally for 10 days, from 3 days before to 6 days after (131)I treatment...
March 20, 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28300573/concomitant-expression-of-ezrin-and-her2-predicts-distant-metastasis-and-poor-prognosis-of-patients-with-salivary-gland-carcinomas
#13
Kazuki Hashimoto, Ryuichi Hayashi, Takashi Mukaigawa, Manabu Yamazaki, Satoshi Fujii
Salivary gland carcinomas (SGCs) exhibit heterogeneous biological behaviors, including the formation of distant metastases, which is a critical event associated with poor prognosis. Ezrin, which is a member of the ezrin-radixin-moesin family of plasma membrane-cytoskeleton linker proteins, may provide a marker for metastasis and poor survival of patients with cancer. The aim of the present study was to investigate the relationship between ezrin expression and the expression of HER2, p53, and Ki-67 as well as clinicopathological factors in SGCs...
March 11, 2017: Human Pathology
https://www.readbyqxmd.com/read/28283209/predicting-novel-salivary-biomarkers-for-the-detection-of-pancreatic-cancer-using-biological-feature-based-classification
#14
Huan-Jun Liu, Yuan-Ying Guo, Du-Jun Li
AIM: The use of saliva as a diagnostic fluid enables non-invasive sampling and thus is a prospective sample for disease tests. This study fully utilized the information from the salivary transcriptome to characterize pancreatic cancer related genes and predict novel salivary biomarkers. METHODS: We calculated the enrichment scores of gene ontology (GO) and pathways annotated in Kyoto Encyclopedia of Genes and Genomes database (KEGG) for pancreatic cancer-related genes...
September 22, 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28272002/the-possible-role-of-diabetes-in-the-etiology-of-laryngeal-cancer
#15
Roberto Menicagli, Gianni Bolla, Laura Menigcali, Anastassia Esseridou
BACKGROUND: Laryngeal cancer and oral cancer are not always correlated with genetic mutations, HPV infection, smoking, and alcohol abuse. In the absence of these risk factors, there is an increase on these cancers with a parallel increase of diabetes. The aim of this study is to verify if diabetes could be a risk factor for the laryngeal cancer. METHODS: A questionnaire was given to a group of ninety laryngectomees to verify if these patients have presented diabetes and xerostomia before surgery...
January 2017: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28270226/first-in-man-mesenchymal-stem-cells-for-radiation-induced-xerostomia-mesrix-study-protocol-for-a-randomized-controlled-trial
#16
Christian Grønhøj, David H Jensen, Peter V Glovinski, Siri Beier Jensen, Allan Bardow, Roberto S Oliveri, Lena Specht, Carsten Thomsen, Sune Darkner, Katalin Kiss, Anne Fischer-Nielsen, Christian von Buchwald
BACKGROUND: Salivary gland hypofunction and xerostomia are major complications following radiotherapy for head and neck cancer and may lead to debilitating oral disorders and impaired quality of life. Currently, only symptomatic treatment is available. However, mesenchymal stem cell (MSC) therapy has shown promising results in preclinical studies. Objectives are to assess safety and efficacy in a first-in-man trial on adipose-derived MSC therapy (ASC) for radiation-induced xerostomia...
March 7, 2017: Trials
https://www.readbyqxmd.com/read/28262804/prognostic-factors-of-palatal-mucoepidermoid-carcinoma-a-retrospective-analysis-based-on-a-double-center-study
#17
Wenguang Xu, Yufeng Wang, Xiaofeng Qi, Junqi Xie, Zheng Wei, Xiteng Yin, Zhiyong Wang, Jian Meng, Wei Han
Mucoepidermoid carcinoma (MEC) of the palate is a common malignancy of minor salivary glands. This study was designed to identify the prognostic factors for MEC of the palate. The medical records of patients diagnosed with MEC of the palate who visited the Department of Oral and Maxillofacial Surgery at Nanjing Stomatological Hospital and the Department of Stomatology at Central Hospital of Xuzhou were retrospectively studied. The prognostic factors were determined using a Cox proportional hazards model. Furthermore, the expression of cancer stem cell (CSC) markers CD44, CD133, Nanog and Sox2 were detected in neoplastic samples of these patients by immunohistochemistry...
March 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28258315/impact-of-low-level-laser-therapy-on-hyposalivation-salivary-ph-and-quality-of-life-in-head-and-neck-cancer-patients-post-radiotherapy
#18
Luiz Felipe Palma, Fernanda Aurora Stabile Gonnelli, Marcelo Marcucci, Rodrigo Souza Dias, Adelmo José Giordani, Roberto Araújo Segreto, Helena Regina Comodo Segreto
Late effects of radiotherapy for head and neck cancer treatment have been increasingly investigated due to its impact on patients' quality of life. The purpose of this study was to evaluate the effect of low-level laser therapy on hyposalivation, low salivary pH, and quality of life in head and neck cancer patients post-radiotherapy. Twenty-nine patients with radiation-induced xerostomia received laser sessions twice a week, during 3 months (24 sessions). For this, a continuous wave Indium-Gallium-Aluminium-Phosphorus diode laser device was used punctually on the major salivary glands (808 nm, 0...
March 3, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28252237/neurobiological-and-psychological-evidence-of-chronic-stress-in-prostate-cancer-patients
#19
C F Sharpley, D R H Christie, V Bitsika, L L Agnew, N M Andronicos, M E McMillan, T M Richards
To measure the prevalence and severity of Generalised Anxiety Disorder (GAD), hypo- and hypercortisolaemia, and their association in a sample of prostate cancer (PCa) patients, 97 Australian PCa patients completed a background questionnaire and the GAD-7, and provided a sample of saliva collected 30-45 min after waking. The mean GAD7 score was 9.67 (SD = 3.09), and prevalence rates for current anxiety were higher than those reported for non-PCa males of a similar age. Mean salivary cortisol concentrations (30...
March 2, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28249655/salivary-gland-pleomorphic-adenoma-in-the-netherlands-a-nationwide-observational-study-of-primary-tumor-incidence-malignant-transformation-recurrence-and-risk-factors-for-recurrence
#20
M H Valstar, M de Ridder, E C van den Broek, M M Stuiver, B A C van Dijk, M L F van Velthuysen, A J M Balm, L E Smeele
INTRODUCTION: Whereas salivary gland pleomorphic adenoma (SGPA) is the most common type of salivary gland tumor, little is known about its epidemiology because national cancer registries do not register this disease. OBJECTIVES: To establish SGPA incidence trends, rates of secondary malignant transformation and recurrence and associated factors in the Netherlands. MATERIALS AND METHODS: Data on incidence, epidemiology, secondary malignant transformation and recurrence were retrieved from the Dutch pathology registry (PALGA) for the years 1992, 1997, 2002, 2007, and 2012...
March 2017: Oral Oncology
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