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https://www.readbyqxmd.com/read/28345028/self-powered-integrated-microfluidic-point-of-care-low-cost-enabling-simple-chip
#1
Erh-Chia Yeh, Chi-Cheng Fu, Lucy Hu, Rohan Thakur, Jeffrey Feng, Luke P Lee
Portable, low-cost, and quantitative nucleic acid detection is desirable for point-of-care diagnostics; however, current polymerase chain reaction testing often requires time-consuming multiple steps and costly equipment. We report an integrated microfluidic diagnostic device capable of on-site quantitative nucleic acid detection directly from the blood without separate sample preparation steps. First, we prepatterned the amplification initiator [magnesium acetate (MgOAc)] on the chip to enable digital nucleic acid amplification...
March 2017: Science Advances
https://www.readbyqxmd.com/read/28338895/photosynthesis-nutrient-accumulation-and-growth-of-two-betula-species-exposed-to-waterlogging-in-late-dormancy-and-in-the-early-growing-season
#2
Ai-Fang Wang, Marja Roitto, Tarja Lehto, Sirkka Sutinen, Jaakko Heinonen, Gang Zhang, Tapani Repo, Ram Oren
Increased risk of soil waterlogging in winter and spring at northern latitudes will potentially affect forest production in the future. We studied gas exchange, chlorophyll content index, chlorophyll fluorescence, nutrient concentration and biomass accumulation in 1-year-old silver (Betula pendula Roth) and pubescent birch (Betula pubescens Ehrh.) seedlings. We hypothesized that B. pubescens has different physiological mechanisms that make it tolerate waterlogging better than B. pendula. The treatments were: (i) no waterlogging throughout the experiment; (ii) 4-week waterlogging during dormancy (dormancy waterlogging 'DW'); (iii) 4-week waterlogging during the early growing season (growth waterlogging 'GW'); and (iv) 4-week DW followed by 4-week GW during the early growing season ('DWGW')...
March 15, 2017: Tree Physiology
https://www.readbyqxmd.com/read/28332537/mapping-vibrational-surface-and-bulk-modes-in-a-single-nanocube
#3
Maureen J Lagos, Andreas Trügler, Ulrich Hohenester, Philip E Batson
Imaging of vibrational excitations in and near nanostructures is essential for developing low-loss infrared nanophotonics, controlling heat transport in thermal nanodevices, inventing new thermoelectric materials and understanding nanoscale energy transport. Spatially resolved electron energy loss spectroscopy has previously been used to image plasmonic behaviour in nanostructures in an electron microscope, but hitherto it has not been possible to map vibrational modes directly in a single nanostructure, limiting our understanding of phonon coupling with photons and plasmons...
March 22, 2017: Nature
https://www.readbyqxmd.com/read/28330645/design-of-fixed-dose-combination-and-physicochemical-characterization-of-enteric-coated-bilayer-tablet-with-circadian-rhythmic-variations-containing-telmisartan-and-pravastatin-sodium
#4
Daoqi Luo, Joo Hee Kim, Chulhun Park, Euichaul Oh, Jun Bum Park, Jing-Hao Cui, Qing-Ri Cao, Beom-Jin Lee
The aim of this study was to investigate a fixed dose combination (FDC) of telmisartan (TEL) and pravastatin sodium (PRA) in enteric-coated bilayer tablets, which was designed for once-daily bedtime dose in order to match circadian rhythmic variations of hypertension and cholesterol synthesis and optimize the patient friendly dosing treatment. Due to the poor aqueous solubility of TEL, a ternary solid dispersions (SD) consisting of TEL, polyethylene glycol 6000 (PEG 6000) and magnesium oxide (MgO) were designed to enhance its dissolution rate in intestinal fluid...
March 18, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28319841/mesoporous-magnesium-oxide-nanoparticles-derived-via-complexation-combustion-for-enhanced-performance-in-carbon-dioxide-capture
#5
Vishwanath Hiremath, Raghavendra Shavi, Jeong Gil Seo
Magnesium oxide (MgO) is a promising candidate for carbon dioxide (CO2) capture at high temperature applicable to pre-combustion capture in an integrated gasification combined cycle (IGCC) scheme. In this work, mesoporous MgO nanoparticles were synthesized via simple complexation-combustion method by using glycine (G) and urea (U) as fuels (F). The obtained sorbents were thoroughly characterized in terms of the crystalline structure, morphology, nature of the fuel, F/O ratio, and their consequent effects on CO2 sorption...
March 10, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28314195/treatment-of-contaminated-greywater-using-pelletised-mine-water-sludge
#6
Suhail N Abed, Suhad A Almuktar, Miklas Scholz
Precipitated sludge (ochre) obtained from a mine water treatment plant was considered as an adsorbent substance for pollutants, since ochre is relatively free from problematic levels of toxic elements, which could impair on the quality of water to be treated. Artificially created ochre pellets from mixing Portland cement with raw ochre sludge were utilised to remediate either high (HC) or low (LC) contaminated synthetic greywater (SGW) in mesocosm-scale stabilisation ponds at 2-day and 7-day contact times under real weather conditions in Salford...
March 14, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28302238/gitelman-syndrome
#7
Qurat Ul Ain Mustafa, Zujaja Hina Haroon, Aamir Ijaz, Muhammad Tanveer Sajid, Muhammad Ayyub
Gitelman syndrome (GS) is the most frequently inherited renal salt-wasting tubulointerstitial disease. It follows variable but usually asymptomatic benign course. We present a rare case of GS that remained clinical enigma. A 22-year male presented with severe episodic fatigue involving all limbs associated with episodes of sinking, palpitations, salt craving, increased thirst and frequent micturition hampering his routine daily activities. Laboratory workup revealed serum potassium, 2.7 mmol/L, serum magnesium, 0...
March 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28301493/obstetrician-s-risk-perception-on-the-prescription-of-magnesium-sulfate-in-severe-preeclampsia-and-eclampsia-a-qualitative-study-in-brazil
#8
Fátima Aparecida Lotufo, Mary Angela Parpinelli, Maria José Osis, Fernanda Garanhani Surita, Maria Laura Costa, José Guilherme Cecatti
INTRODUCTION: Magnesium sulfate (MgSO4) is the drug of choice for the prevention and control of seizures in the management of severe preeclampsia/eclampsia. Several barriers have been identified in the use of MgSO4, especially in low and middle-income settings. OBJECTIVE: To describe the obstetrician's perception on possible reasons for underutilizing magnesium sulfate to treat preeclampsia/eclampsia. METHOD: A qualitative clinical study, based on phenomenological reference by semi-structured interviews and open-ended discussions with obstetricians of the public healthcare system in primary care units (PCU) and referral maternity hospitals (RMH), in a southeastern Brazilian city...
2017: PloS One
https://www.readbyqxmd.com/read/28298783/study-of-effect-of-magnesium-sulphate-in-management-of-acute-organophosphorous-pesticide-poisoning
#9
H N Vijayakumar, Sudheesh Kannan, C Tejasvi, Devika Rani Duggappa, K M Veeranna Gowda, S S Nethra
BACKGROUND: Organophosphorus compound poisoning (OPCP) is a major public health problem in developing countries like India. Atropine and oximes remain the main-stay of management. Magnesium sulfate (MgSO4) has shown benefit in the management of OPCP. AIMS: This study was designed to assess the effect of MgSO4 on outcome in OPCP patients admitted to Intensive Care Unit (ICU). SETTINGS AND DESIGN: Double-blind prospective randomized clinical trial in an ICU of tertiary care institution...
January 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/28296769/oral-magnesium-supplementation-improves-glycemic-control-and-lipid-profile-in-children-with-type-1-diabetes-and-hypomagnesaemia
#10
Doaaa Shahbah, Tamer Hassan, Saeed Morsy, Hosam El Saadany, Manar Fathy, Ashgan Al-Ghobashy, Nahla Elsamad, Ahmed Emam, Ahmed Elhewala, Boshra Ibrahim, Sherief El Gebaly, Hany El Sayed, Hanan Ahmed
Dietary supplementation with magnesium (Mg) in addition to classical therapies for diabetes may help in prevention or delaying of diabetic complications.We aimed to evaluate the status of serum Mg in children with type 1 diabetes and assessing its relationship to glycemic control and lipid profile. Then evaluating the effect of oral Mg supplementation on glycemic control and lipid parameters.We included 71 children at Pediatric Endocrinology Outpatient Clinic, Zagazig University, Egypt with type 1 diabetes and assessed HBA1c, lipid profile, and serum Mg at the start of study...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28294445/the-challenge-of-nutritional-profiling-of-a-protein-free-feed-module-for-children-on-low-protein-tube-feeds-with-organic-acidaemias
#11
A Daly, S Evans, C Ashmore, S Chahal, S Santra, A MacDonald
BACKGROUND: Enteral tube feeding for children with organic acidaemias (OA) is recommended. Protein restriction, providing minimum safe levels of protein intake, is advocated. Standard paediatric tube feeding formulae provide more than the minimum safe protein requirements and are unsuitable in OA without modification. Modified paediatric enteral feeds consist of several modular ingredients. The aim of this prospective longitudinal interventional study was to assess the efficacy of a premeasured novel protein-free module developed for children aged over 12 months compared to conventional practice...
March 10, 2017: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/28292990/-nephropathy-in-patients-undergoing-cancer-drug-therapy-platinum-derivatives-cisplatin-and-carboplatin
#12
Ayumu Matsuoka, Yuichi Ando
Cisplatin, a first-generation platinum derivative, is one of the most widely used anticancer agents and can treat a broad spectrum of malignancies. Cisplatin-induced nephrotoxicity is a major dose-limiting side effect resulting from damage to the proximal tubules of the kidney. This nephrotoxicity can be prevented by lowering the concentration of cisplatin and shortening the period of cisplatin exposure to the proximal tubules. In clinical practice, high-volume hydration(>3 L intravenous isotonic saline), forced diuresis(mannitol and/or furosemide), and magnesium supplementation have been generally used to lower the risk of cisplatin-induced nephrotoxicity...
March 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28280316/the-impact-of-hypomagnesemia-on-erectile-dysfunction-in-elderly-non-diabetic-stage-3-and-4-chronic-kidney-disease-patients-a-prospective-cross-sectional-study
#13
Omer Toprak, Yasin Sarı, Akif Koç, Erhan Sarı, Ali Kırık
BACKGROUND: Erectile dysfunction (ED) is common in older men with chronic kidney disease. Magnesium is essential for metabolism of nitric oxide which helps in penile erection. There is little information available about the influence of serum magnesium on ED. The aim of the study was to assess the influence of hypomagnesemia on ED in elderly chronic kidney disease patients. SUBJECTS AND METHODS: A total of 372 patients aged 65-85 years, with an estimated glomerular filtration rate of 60-15 mL/min/1...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28276070/a-retrospective-evaluation-of-furosemide-and-mannitol-for-prevention-of-cisplatin-induced-nephrotoxicity
#14
C M Mach, C Kha, D Nguyen, J Shumway, K M Meaders, M Ludwig, M Y Williams-Brown, M L Anderson
WHAT IS KNOWN AND OBJECTIVE: Nephrotoxicity is a recognized side effect of cisplatin chemotherapy. However, the optimal strategy for preventing cisplatin-induced nephrotoxicity, if any, remains unclear. The primary objective for this study was to determine whether mannitol or furosemide provides better nephroprotection when administered with hydration prior to weekly, low-dose cisplatin concurrently with whole pelvic radiotherapy. METHODS: Clinical data were abstracted from all women who underwent chemoradiation for FIGO IB2-IVA cervical cancer at a regional safety net health system between January 2009 and December 2014...
March 9, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28273891/effects-of-long-term-magnesium-supplementation-on-endothelial-function-and-cardiometabolic-risk-markers-a-randomized-controlled-trial-in-overweight-obese-adults
#15
Peter J Joris, Jogchum Plat, Stephan J L Bakker, Ronald P Mensink
Long-term magnesium supplementation improves arterial stiffness, a cardiovascular disease risk marker. Effects on endothelial function may be another mechanism whereby increased magnesium intakes affect cardiovascular risk. Therefore, a 24-week, randomized, double-blind, placebo-controlled trial was performed to examine effects of magnesium supplementation on endothelial function and cardiometabolic risk markers. Fifty-two overweight and obese subjects (30 men and 22 women, age 62 ± 6 years) were randomized to receive either three times daily magnesium (total dose: 350 mg) or placebo capsules...
December 2017: Scientific Reports
https://www.readbyqxmd.com/read/28270819/effects-of-low-ph-on-photosynthesis-related-physiological-parameters-and-nutrient-profiles-of-citrus
#16
An Long, Jiang Zhang, Lin-Tong Yang, Xin Ye, Ning-Wei Lai, Ling-Ling Tan, Dan Lin, Li-Song Chen
Seedlings of "Xuegan" (Citrus sinensis) and "Sour pummelo" (Citrus grandis) were irrigated daily with a nutrient solution at a pH of 2.5, 3, 4, 5, or 6 for 9 months. Thereafter, the following responses were investigated: seedling growth; root, stem, and leaf concentrations of nutrient elements; leaf gas exchange, pigment concentration, ribulose-1,5-bisphosphate carboxylase/oxygenase activity and chlorophyll a fluorescence; relative water content, total soluble protein level, H2O2 production and electrolyte leakage in roots and leaves...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28265965/hypophosphatemia-nutritional-status-body-composition-and-mortality-in-hemodialysis-patients
#17
Cristina Garagarza, Ana Valente, Cristina Caetano, Telma Oliveira, Pedro Ponce, Ana Paula Silva
PURPOSE: The aim of the present study was to investigate the relationship between serum phosphate levels, clinical parameters, body composition, and mortality. METHODS: Multicenter longitudinal observational study of a cohort of 3552 patients in hemodialysis (HD) from 34 Nephrocare dialysis units in Portugal with 24 months of follow-up. Patients were divided into three groups depending on their serum phosphorus (<3.5; 3.5-5.5; >5.5 mg/dL). Statistical tests were performed with SPSS, version 20...
March 6, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28265411/outcomes-of-an-inpatient-medical-nutritional-rehabilitation-protocol-in-children-and-adolescents-with-eating-disorders
#18
Rebecka Peebles, Andrew Lesser, Courtney Cheek Park, Kerri Heckert, C Alix Timko, Eleni Lantzouni, Ronald Liebman, Laurel Weaver
BACKGROUND: Medical stabilization through inpatient nutritional rehabilitation is often necessary for patients with eating disorders (EDs) but includes the inherent risk of refeeding syndrome. Here we describe our experience of implementing and sustaining an inpatient nutritional rehabilitation protocol designed to strategically prepare patients with EDs and their families for discharge to a home setting in an efficient and effective manner from a general adolescent medicine unit. We report outcomes at admission, discharge, and 4-weeks follow-up...
2017: Journal of Eating Disorders
https://www.readbyqxmd.com/read/28262623/second-generation-magnesium-scaffold-magmaris-device-design-and-preclinical-evaluation-in-a-porcine-coronary-artery-model
#19
Ron Waksman, Philine Zumstein, Martin Pritsch, Eric Wittchow, Michael Haude, Capucine Lapointe-Corriveau, Guy Leclerc, Michael Joner
AIMS: The second-generation drug-eluting absorbable magnesium scaffold Magmaris, recently introduced for treatment of obstructive coronary atherosclerotic lesions, suggests a good safety profile, but preclinical assessment is important for predicting clinical performance. METHODS AND RESULTS: Ninety Magmaris scaffolds were implanted into non-diseased porcine and rabbit models. A bioresorbable vascular scaffold (Absorb) and the permanent drugeluting stent (Xience Xpedition) served as controls...
March 7, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28258078/a-short-term-low-magnesium-diet-reduces-autoimmune-arthritis-severity-and-synovial-tissue-gene-expression
#20
Max Brenner, Teresina Laragione, Percio S Gulko
Magnesium has been suggested to have anti-inflammatory properties in short-term mostly in vitro studies. To examined the effect of dietary magnesium modifications in arthritis severity and joint damage DA rats were placed on one of three diet regimens before the induction of autoimmune pristane-induced arthritis (PIA): a four-week low-magnesium diet, normal diet and a magnesium-supplemented diet. The diets were switched to a normal diet fourteen days after the induction of PIA (typical time of disease onset)...
March 3, 2017: Physiological Genomics
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