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https://www.readbyqxmd.com/read/28526433/risk-of-low-birth-weight-and-micronutrient-deficiencies-in-neonates-from-mothers-after-gastric-bypass-a-case-control-study
#1
Geraldine Gascoin, Maxime Gerard, Agnès Sallé, Guillaume Becouarn, Stephanie Rouleau, Loïc Sentilhes, Régis Coutant
BACKGROUND: An increased risk of small-for-gestational-age infants after maternal bariatric surgery has been shown. The risk of micronutrients deficiencies in these neonates is unclear. OBJECTIVE: To screen for micronutrients deficiencies in newborns of mothers with gastric bypass. SETTINGS: University hospital in Angers, France. METHODS: This study compared the clinical and cord blood biological characteristics of 56 newborns of mothers with prior Roux-en-Y gastric bypass (RYGB) and 56 newborns of nonobese healthy mothers after normal pregnancy (controls), followed between January 3, 2008 and October 31, 2012...
March 27, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28514635/specialization-to-extremely-low-nutrient-soils-limits-the-nutritional-adaptability-of-plant-lineages
#2
G Anthony Verboom, William D Stock, Michael D Cramer
Specialization to extreme selective situations promotes the acquisition of traits whose coadaptive integration may compromise evolutionary flexibility and adaptability. We test this idea in the context of the foliar stoichiometry of plants native to the South African Cape. Whereas foliar concentrations of nitrogen, phosphorus (P), potassium (K), calcium, magnesium, and sodium showed strong phylogenetic signal, as did the foliar ratios of these nutrients to P, the same was not true of the corresponding soil values...
June 2017: American Naturalist
https://www.readbyqxmd.com/read/28512220/increasing-intracellular-magnesium-levels-with-the-31-amino-acid-mgts-protein
#3
Hanbo Wang, Xuefeng Yin, Mona Wu Orr, Michael Dambach, Rebecca Curtis, Gisela Storz
Synthesis of the 31-amino acid, inner membrane protein MgtS (formerly denoted YneM) is induced by very low Mg(2+) in a PhoPQ-dependent manner in Escherichia coli Here we report that MgtS acts to increase intracellular Mg(2+) levels and maintain cell integrity upon Mg(2+) depletion. Upon development of a functional tagged derivative of MgtS, we found that MgtS interacts with MgtA to increase the levels of this P-type ATPase Mg(2+) transporter under Mg(2+)-limiting conditions. Correspondingly, the effects of MgtS upon Mg(2+) limitation are lost in a ∆mgtA mutant, and MgtA overexpression can suppress the ∆mgtS phenotype...
May 16, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28508256/the-role-of-micronutrients-in-alopecia-areata-a-review
#4
REVIEW
Jordan M Thompson, Mehwish A Mirza, Min Kyung Park, Abrar A Qureshi, Eunyoung Cho
Alopecia areata (AA) is a common, non-scarring form of hair loss caused by immune-mediated attack of the hair follicle. As with other immune-mediated diseases, a complex interplay between environment and genetics is thought to lead to the development of AA. Deficiency of micronutrients such as vitamins and minerals may represent a modifiable risk factor associated with development of AA. Given the role of these micronutrients in normal hair follicle development and in immune cell function, a growing number of investigations have sought to determine whether serum levels of these nutrients might differ in AA patients, and whether supplementation of these nutrients might represent a therapeutic option for AA...
May 15, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28496346/do-we-need-to-measure-vitamin-b12-and-magnesium-in-morbidly-obese-patients-with-type-2-diabetes-mellitus
#5
Anna Wåhlén, Arvo Haenni, Hans-Erik Johansson
OBJECTIVE: We aimed to investigate the prevalence of B12 deficiency in metformin-treated, morbidly obese, type 2 diabetes mellitus (T2DM) patients, compared to morbidly obese controls, as well as to evaluate the magnesium status. DESIGN: Retrospective cross-sectional analysis of plasma vitamin B12, plasma magnesium, glucometabolic status and clinical measurements in all consecutive morbidly obese patients was conducted during 1 year. SETTING: Outpatient Clinic of Obesity Care...
2017: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/28489728/novel-adjunct-drugs-reverse-endothelial-glycocalyx-damage-after-hemorrhagic-shock-in-rats
#6
Ivo P Torres Filho, Luciana N Torres, Christi Salgado, Michael A Dubick
INTRODUCTION: There is interest in the small-volume therapeutic use of adjunct drugs for treating hemorrhagic shock (HS). However, critical information is only partially available on mechanisms of action of promising compounds such as adenosine-lidocaine-Magnesium (ALM), beta-hydroxybutyrate plus melatonin (BHB/M), and poloxamer 188 (P-188). Therefore, we tested the hypothesis that these adjuncts would reverse HS-induced damage to microvascular endothelial glycocalyx and hemodynamics...
May 9, 2017: Shock
https://www.readbyqxmd.com/read/28487477/a-magnesium-transporter-osmgt1-plays-a-critical-role-in-salt-tolerance-in-rice
#7
Zhi Chang Chen, Naoki Yamaji, Tomoaki Horie, Jing Che, Gynheung An, Jian Feng Ma, Jian Li
Salt stress is one of the major factors limiting rice production globally. Although several transporters involved in thesalt-tolerance have been identified in rice, the mechanisms regulating their transport activity are still poorly understood. Here, we show evidence that a rice Mg transporter OsMGT1 is required for the salt-tolerance probably by regulating transport activity of OsHKT1;5, a key transporter for the removal of Na+ from the xylem sap at the root mature zone. Knockout of OsMGT1 did not affect total Na uptake, but increased Na concentration in the shoots and xylem sap, resulting in a significant increase in salt sensitivity at low external Mg2+ concentration (20-200 μM)...
May 9, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28471366/structure-of-the-family-b-dna-polymerase-from-the-hyperthermophilic-archaeon-pyrobaculum-calidifontis
#8
Jingxu Guo, Wenling Zhang, Alun R Coker, Steve P Wood, Jonathan B Cooper, Shazeel Ahmad, Syed Ali, Naeem Rashid, Muhummad Akhtar
The family B DNA polymerase from Pyrobaculum calidifontis (Pc-polymerase) consists of 783 amino acids and is magnesium-ion dependent. It has an optimal pH of 8.5, an optimal temperature of 75°C and a half-life of 4.5 h at 95°C, giving it greater thermostability than the widely used Taq DNA polymerase. The enzyme is also capable of PCR-amplifying larger DNA fragments of up to 7.5 kb in length. It was shown to have functional, error-correcting 3'-5' exonuclease activity, as do the related high-fidelity DNA polymerases from Pyrococcus furiosus, Thermococcus kodakarensis KOD1 and Thermococcus gorgonarius, which have extensive commercial applications...
May 1, 2017: Acta Crystallographica. Section D, Structural Biology
https://www.readbyqxmd.com/read/28467043/vo2-nanoflakes-as-the-cathode-material-of-hybrid-magnesium-lithium-ion-batteries-with-high-energy-density
#9
Cunyuan Pei, Fangyu Xiong, Jinzhi Sheng, Yameng Yin, Shuangshuang Tan, Dandan Wang, Chunhua Han, Qinyou An, Liqiang Mai
The hybrid magnesium-lithium-ion batteries (MLIBs) combining the dendrite-free deposition of the Mg anode and the fast Li intercalation cathode are better alternatives to Li-ion batteries (LIBs) in large-scale power storage systems. In this article, we reported hybrid MLIBs assembled with the VO2 cathode, dendrite-free Mg anode, and the Mg-Li dual-salt electrolyte. Satisfactorily, the VO2 cathode delivered a stable plateau at about 1.75 V, and a high specific discharge capacity of 244.4 mA h g(-1). To the best of our knowledge, the VO2 cathode displays the highest energy density of 427 Wh kg(-1) among reported MLIBs in coin-type batteries...
May 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28465369/statins-time-to-rationalise-lfts
#10
(no author information available yet)
Statins: time to rationalise LFTs? ● Limited evidence for low-cost devices to improve adherence ● MHRA safety alert: hyoscine butylbromide (Buscopan) injection ● Faecal microbiota transplantation for ulcerative colitis ● Magnesium for nocturnal leg cramps ● NSAIDs and risk of out-of-hospital cardiac arrest ● Off-label antidepressant prescribing.
May 2, 2017: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/28458742/composites-of-aluminum-alloy-and-magnesium-alloy-with-graphite-showing-low-thermal-expansion-and-high-specific-thermal-conductivity
#11
Valerio Oddone, Benji Boerner, Stephanie Reich
High thermal conductivity, low thermal expansion and low density are three important features in novel materials for high performance electronics, mobile applications and aerospace. Spark plasma sintering was used to produce light metal-graphite composites with an excellent combination of these three properties. By adding up to 50 vol.% of macroscopic graphite flakes, the thermal expansion coefficient of magnesium and aluminum alloys was tuned down to zero or negative values, while the specific thermal conductivity was over four times higher than in copper...
2017: Science and Technology of Advanced Materials
https://www.readbyqxmd.com/read/28458365/evaluation-of-sucrose-fatty-acid-esters-as-lubricants-in-tablet-manufacturing
#12
Shohei Nakamura, Nozomi Ishii, Naoyuki Nakashima, Takatoshi Sakamoto, Hiroshi Yuasa
Lubricants are essential additives in tablet formulations. Magnesium stearate (Mg-St) is the most commonly used lubricant in tableting. Here, we used sucrose fatty acid ester (SE) as an additive to manufacture tablets by direct compression. We evaluated the effects of hydrophile-lipophile balance (HLB) and the amount of SE on the flowability of a pharmaceutical powder using angle of repose and practical angle of internal friction measurements. In addition, we investigated the effects of SE on tablet properties...
2017: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28457398/serum-magnesium-and-related-factors-in-long-term-renal-transplant-recipients-an-observational-study
#13
N Rodrigues, A Santana, J Guerra, M Neves, C Nascimento, J Gonçalves, A G da Costa
BACKGROUND: Low serum magnesium (MgS) is a known risk factor for cardiovascular and mineral bone disease. In renal transplant recipients (RTRs), low MgS levels have been related to higher glomerular filtration rates (GFR) and with calcineurin inhibitors, particularly tacrolimus. We aimed to evaluate MgS in renal transplant recipients with over 1 year of follow-up to establish related risk factors and the impact of the use of cyclosporine versus tacrolimus. METHODS: Cross-sectional study of 94 RTRs with more than 12 months of follow-up...
May 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28452741/pressure-dependence-of-transverse-acoustic-phonon-energy-in-ferropericlase-across-the-spin-transition
#14
Hiroshi Fukui, Alfred Q R Baron, Daisuke Ishikawa, Hiroshi Uchiyama, Yasuo Ohishi, Taku Tsuchiya, Hisao Kobayashi, Takuya Matsuzaki, Takashi Yoshino, Tomoo Katsura
We investigated transverse acoustic (TA) phonons in iron-bearing magnesium oxide (ferropericlase) up to 56 GPa using inelastic x-ray scattering (IXS). The results show that the energy of the TA phonon far from the Brillouin zone center suddenly increases with increasing pressure above the spin transition pressure of ferropericlase. Ab initio calculations revealed that the TA phonon energy far from the Brillouin zone center is higher in the low-spin state than in the high spin state; that the TA phonon energy depend weakly on pressure; and that the energy gap between the TA and the lowest-energy-optic phonons is much narrower in the low-spin state than in the high-spin state...
June 21, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28452073/analyzing-the-capacity-of-the-daphnia-magna-and-pseudokirchneriella-subcapitata-bioavailability-models-to-predict-chronic-zinc-toxicity-at-high-ph-and-low-ca-concentrations-and-formulation-of-a-generalized-bioavailability-model-gbam-for-d-magna
#15
Tina Van Regenmortel, Olivier Berteloot, Colin R Janssen, Karel A C De Schamphelaere
Risk assessment in the European Union implements Zn bioavailability models to derive predicted no effect concentrations (PNEC) for Zn. These models are validated within certain 'boundaries', i.e. pH≤8 and Ca concentrations ≥ 5mg/L, but a substantial fraction of the European surface waters falls outside these boundaries. Therefore, we evaluated if the chronic Zn Biotic Ligand Model (BLM) for Daphnia magna and the chronic bioavailability model for Pseudokirchneriella subcapitata, can be extrapolated to pH above 8 and Ca concentrations below 5mg/L...
April 27, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28451437/an-assessment-of-agricultural-pesticide-use-in-iran-2012-2014
#16
Zaim Morteza, Seyed Behzad Mousavi, Mohammad Ali Baghestani, Antero Aitio
BACKGROUND: This is the first published assessment on agricultural pesticide use in Iran with the aim to identify pesticide products with a potential of causing acute or chronic hazard to human health. It also establishes a baseline for future comparisons and for trend assessments. METHODS: The amounts of imported technical materials for formulation by local manufacturers as well as imported final product formulations were extracted from the registration data of the Plant Protection Organization of Iran in 2012-2014...
2017: Journal of Environmental Health Science & Engineering
https://www.readbyqxmd.com/read/28440405/copy-number-variation-analysis-in-familial-nonsyndromic-congenital-anomalies-of-the-kidney-and-urinary-tract-evidence-for-the-causative-role-of-a-transposable-element-associated-genomic-rearrangement
#17
Ekaterini Siomou, Artemis G Mitsioni, Vasileios Giapros, Ioanna Bouba, Dimitrios Noutsopoulos, Ioannis Georgiou
Most congenital anomalies of the kidney and urinary tract (CAKUT) are sporadic, but familial occurrence has been described, suggesting a genetic contribution. Copy‑number variations (CNVs) were detected in patients with CAKUT to identify possible novel genomic regions associated with CAKUT. CNVs were investigated in 7 children with CAKUT from three unrelated families using array comparative genomic hybridization: female monozygotic twins with bilateral duplex collecting system/vesicoureteral reflux (VUR)/unilateral renal hypodyspasia (URHD); two male siblings with VUR/URHD; 3 male second cousins, one with bilateral VUR/URHD, one with bilateral VUR and one with ureterovesical junction obstruction (UVJO)...
June 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28438887/a-systematic-review-of-strategies-to-prevent-cisplatin-induced-nephrotoxicity
#18
Daniel J Crona, Aimee Faso, Tomohiro F Nishijima, Kathleen A McGraw, Matthew D Galsky, Matthew I Milowsky
INTRODUCTION: Cisplatin, a platinum-based antineoplastic agent, is the cornerstone for the treatment of many malignancies. Nephrotoxicity is the primary dose-limiting toxicity, and various hydration regimens and supplementation strategies are used to prevent cisplatin-induced kidney injury. However, evidence-based recommendations on specific hydration regimens are limited. A systematic review was performed to evaluate clinical studies that have examined hydration and supplementation strategies to prevent cisplatin-induced nephrotoxicity...
May 2017: Oncologist
https://www.readbyqxmd.com/read/28438429/association-of-serum-magnesium-level-with-poor-glycemic-control-and-renal-functions-in-nepalese-patients-with-type-2-diabetes-mellitus
#19
Daya Ram Pokharel, Dipendra Khadka, Manoj Sigdel, Naval Kishor Yadav, Ramchandra Kafle, Ravindra Mohan Sapkota, Sanjay Kumar Jha
BACKGROUND: Hypomagnesaemia has been shown to be associated with type 2 diabetes mellitus (T2DM) and its complications. The present study investigated the association of hypomagnesaemia with T2DM and its complications in patients hailed mostly from the western hilly region of Nepal. METHODS: This study was conducted among 150 type 2 diabetic patients and 150 of non-diabetic controls between May to September 2016. Relevant demographic, anthropometric, physiological and biochemical variables were measured using standard protocols...
April 6, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28433931/alkaline-earth-elements-of-scalp-hair-and-presence-of-hypertension-in-housewives-a-perspective-of-chronic-effect
#20
Bin Wang, Lailai Yan, Ying Sun, Jingjing Yan, Qun Lu, Jingxu Zhang, Zhiwen Li
The relationship between population intakes of alkaline-earth elements (AEEs) and hypertension risk remains under discussion. Hair AEE concentrations can indicate their intake levels into human body. Thus, we aimed to investigate an association of hair AEE concentrations with hypertension risk, and the potential effect of dietary habit on this association. We recruited 398 housewives [163 subjects with hypertension (case group) and 235 subjects without hypertension (control group)] in Shanxi Province of north China...
April 6, 2017: Chemosphere
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