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https://www.readbyqxmd.com/read/28918394/apolipoprotein-l1-confers-ph-switchable-ion-permeability-to-phospholipid-vesicles
#1
Jonathan Bruno, Nicola Pozzi, Jonathan Oliva, John C Edwards
Apolipoprotein L1 (ApoL1) is a human serum protein conferring resistance to African trypanosomes, and certain ApoL1 variants increase susceptibility to some progressive kidney diseases. ApoL1 has been hypothesized to function like a pore-forming colicin and been reported to have permeability effects on both intracellular and plasma membranes. Here, to gain insight into how ApoL1 may function in vivo, we used vesicle-based ion-permeability, direct membrane-association, and intrinsic fluorescence to study the activities of purified recombinant ApoL1...
September 15, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28918139/comparison-of-milk-protein-composition-and-rennet-coagulation-properties-in-native-swedish-dairy-cow-breeds-and-high-yielding-swedish-red-cows
#2
Nina A Poulsen, Maria Glantz, Anette K Rosengaard, Marie Paulsson, Lotte B Larsen
Recent studies have reported a very high frequency of noncoagulating milk in Swedish Red cows. The underlying factors are not fully understood. In this study, we explored rennet-induced coagulation properties and relative protein profiles in milk from native Swedish Mountain and Swedish Red Polled cows and compared them with a subset of noncoagulating (NC) and well-coagulating (WC) milk samples from modern Swedish Red cows. The native breeds displayed a very low prevalence of NC milk and superior milk coagulation properties compared with Swedish Red cows...
September 13, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28917869/high-aspect-ratio-phospho-calcified-rock-candy-like-cellulose-nanowhiskers-of-wastepaper-applicable-in-osteogenic-differentiation-of-hmscs
#3
Mohsen Shahrousvand, Fatemeh Ahmadi Tabar, Ehsan Shahrousvand, Amir Babaei, Mohammad Mahdi Hasani-Sadrabadi, Gity Mir Mohamad Sadeghi, Hafez Jafari, Ali Salimi
The aim of this study was to prepare cellulose nanowhiskers (CNWs) from wastepaper powder (WPP), as an environmentally friendly approach for obtaining the source material, which is a highly available and low-cost precursor for cellulose nanomaterial processing. Acid hydrolysis and calcification treatments were employed for extraction of CNWs and preparation of novel phospho-calcified cellulose nanowhiskers (PCCNWs). CNWs and PCCNWs were analyzed through optical microscopy (OM), scanning electron microscopy (SEM), Fourier-transformed infrared spectra (FTIR) and X-ray diffraction analysis (XRD)...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28917674/prognostic-value-of-risk-factors-calcium%C3%A2-score-coronary-cta-myocardial%C3%A2-perfusion-imaging-and-invasive%C3%A2-coronary-angiography-in-kidney%C3%A2-transplantation-candidates
#4
Simon Winther, My Svensson, Hanne Skou Jørgensen, Laust Dupont Rasmussen, Niels Ramsing Holm, Lars Christian Gormsen, Kirsten Bouchelouche, Hans Erik Bøtker, Per Ivarsen, Morten Bøttcher
OBJECTIVES: This study sought to perform a prospective head-to-head comparison of the predictive value of clinical risk factors and a variety of cardiac imaging modalities including coronary artery calcium score (CACS), coronary computed tomography angiography (CTA), single-photon emission computed tomography (SPECT), and invasive coronary angiography (ICA) on major adverse cardiac events (MACE) and all-cause mortality in kidney transplantation candidates. BACKGROUND: Current guidelines recommend screening for coronary artery disease in kidney transplantation candidates...
September 9, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28916883/different-post-processing-conditions-for-3d-bioprinted-%C3%AE-tricalcium-phosphate-scaffolds
#5
Liciane Sabadin Bertol, Rodrigo Schabbach, Luis Alberto Loureiro Dos Santos
The development of 3D printing hardware, software and materials has enabled the production of bone substitute scaffolds for tissue engineering. Calcium phosphates cements, such as those based on α-tricalcium phosphate (α-TCP), have recognized properties of osteoinductivity, osteoconductivity and resorbability and can be used to 3D print scaffolds to support and induce tissue formation and be replaced by natural bone. At present, however, the mechanical properties found for 3D printed bone scaffolds are only satisfactory for non-load bearing applications...
September 15, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28916741/enhancement-of-water-diffusion-and-compression-performance-of-crosslinked-alginate-films-with-a-minuscule-amount-of-graphene-oxide
#6
Ángel Serrano-Aroca, Juan-Francisco Ruiz-Pividal, Mar Llorens-Gámez
A series of calcium alginate composite hydrogels with several calcium chloride contents ranging from 3 to 18 wt.% with and without 0.1 wt.% of graphene oxide (GO) was prepared in order to study the effect of crosslinking and nanofilling on water diffusion and compression performance. Thus, for high crosslinker contents, these composite hydrogels exhibited ultrafast diffusion of liquid water and excellent compression properties as compared with control (0 wt.% GO and the same crosslinking). These remarkable results are produced due to calcium cations are able to crosslink alginate and also graphene oxide nanosheets to form large crosslinked GO networks inside the calcium alginate hydrogels...
September 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28916335/troxerutin-abrogates-mitochondrial-oxidative-stress-and-myocardial-apoptosis-in-mice-fed-calorie-rich-diet
#7
Rajagopalan Geetha, Chandrasekaran Sathiya Priya, Carani Venkatraman Anuradha
Mitochondrial oxidative stress plays a major role in the pathogenesis of myocardial apoptosis in metabolic syndrome (MS) patients. In this study, we investigated the effect of troxerutin (TX), an antioxidant on mitochondrial oxidative stress and apoptotic markers in heart of mice fed fat and fructose-rich diet. Adult male Mus musculus mice were fed either control diet or high fat, high fructose diet (HFFD) for 60 days to induce MS. Mice from each dietary group were divided into two on the 16th day and were either treated or untreated with TX (150 mg/kg bw, p...
September 12, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28916241/relationship-of-echocardiographic-epicardial-fat-thickness-and-epicardial-fat-volume-by-computed-tomography-with-coronary-artery-calcification-data-from-the-caesar-study
#8
Byung Jin Kim, Jung Gyu Kang, Sung Ho Lee, Jong Young Lee, Ki Chul Sung, Bum Soo Kim, Jin Ho Kang
BACKGROUND AND AIMS: No study has assessed the association between echocardiographic epicardial fat thickness (EFT) and computed tomography (CT)-based epicardial fat volume (EFV) and coronary artery calcification. The aim of this study is to evaluate the association between EFT and EFV and coronary artery calcification. METHODS: Among the 2,299 individuals enrolled in the CArdiometabolic risk, Epicardial fat, and Subclinical Atherosclerosis Registry (CAESAR) study, 2,276 (1,851 men; mean age 45 ± 8...
September 12, 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/28915538/long-term-t3-and-t4-treatment-as-an-alternative-to-aerobic-exercise-training-in-improving-cardiac-function-post-myocardial-infarction
#9
Rayane Brinck Teixeira, Alexsandra Zimmer, Alexandre Luz de Castro, Bruna Gazzi de Lima-Seolin, Patrick Türck, Rafaela Siqueira, Adriane Belló-Klein, Pawan K Singal, Alex Sander da Rosa Araujo
Here we aimed to compare the beneficial effects of T3 and T4 hormone treatment to those provided by aerobic exercise training in Wistar rats post-myocardial infarction (MI). Rats in one group were SHAM-operated and in the other group were subjected to MI surgery. One week after surgery, the MI group animals either received T3 and T4 hormones by gavage or underwent a low intensity aerobic exercise training protocol on a treadmill, and both treatments lasted until 10 weeks after MI. Untreated SHAM-operated and MI groups were also followed for the same duration...
September 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28914773/vitamin-d-nutritional-status-and-its-related-factors-for-chinese-children-and-adolescents-in-2010-2012
#10
Yichun Hu, Jing Chen, Rui Wang, Min Li, Chunfeng Yun, Weidong Li, Yanhua Yang, Jianhua Piao, Xiaoguang Yang, Lichen Yang
Vitamin D plays a critical role in calcium and phosphate metabolism and helps maintain skeletal integrity in childhood, yet vitamin D status in Chinese children and adolescents is not well documented. The aim of this study was to assess the vitamin D status and analyze the risk factors for vitamin D deficiency in Chinese children and adolescents aged 6-17 years. Serum 25 hydroxyvitamin D (25(OH)D) was measured with a radioimmunoassay kit in 15,000 children and adolescent participants in the Chinese national nutrition and health survey (CNNHS) 2010-2012...
September 15, 2017: Nutrients
https://www.readbyqxmd.com/read/28913412/addition-of-wollastonite-fibers-to-calcium-phosphate-cement-increases-cell-viability-and-stimulates-differentiation-of-osteoblast-like-cells
#11
Juliana Almeida Domingues, Mariana Motisuke, Celso Aparecido Bertran, Moema A Hausen, Eliana Aparecida de Rezende Duek, José Angelo Camilli
Calcium phosphate cement (CPC) that is based on α-tricalcium phosphate (α-TCP) is considered desirable for bone tissue engineering because of its relatively rapid degradation properties. However, such cement is relatively weak, restricting its use to areas of low mechanical stress. Wollastonite fibers (WF) have been used to improve the mechanical strength of biomaterials. However, the biological properties of WF remain poorly understood. Here, we tested the response of osteoblast-like cells to being cultured on CPC reinforced with 5% of WF (CPC-WF)...
2017: TheScientificWorldJournal
https://www.readbyqxmd.com/read/28912972/denosumab-for-male-hemodialysis-patients-with-low-bone-mineral-density-a-case-control-study
#12
Hiroya Takami, Kazunori Washio, Hiromichi Gotoh
Denosumab increases bone mineral density (BMD) in patients not receiving hemodialysis therapy. However, limited data are available in the literature concerning the use of denosumab in hemodialysis patients. We treated male hemodialysis patients with low radius BMD with denosumab therapy for 1 year and evaluated its effect on radius BMD. Seventeen patients were treated with denosumab 60 mg every 6 months, and 20 patients were not treated with denosumab (control group). At seven days, the mean corrected calcium level decreased from 9...
2017: International Journal of Nephrology
https://www.readbyqxmd.com/read/28912545/the-cacna1h-mutation-in-the-gaers-model-of-absence-epilepsy-enhances-t-type-ca-2-currents-by-altering-calnexin-dependent-trafficking-of-cav3-2-channels
#13
Juliane Proft, Yuriy Rzhepetskyy, Joanna Lazniewska, Fang-Xiong Zhang, Stuart M Cain, Terrance P Snutch, Gerald W Zamponi, Norbert Weiss
Low-voltage-activated T-type calcium channels are essential contributors to the functioning of thalamocortical neurons by supporting burst-firing mode of action potentials. Enhanced T-type calcium conductance has been reported in the Genetic Absence Epilepsy Rat from Strasbourg (GAERS) and proposed to be causally related to the overall development of absence seizure activity. Here, we show that calnexin, an endoplasmic reticulum integral membrane protein, interacts with the III-IV linker region of the Cav3...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28912449/red-and-green-colors-emitting-spherical-shaped-calcium-molybdate-nanophosphors-for-enhanced-latent-fingerprint-detection
#14
L Krishna Bharat, G Seeta Rama Raju, Jae Su Yu
We report the synthesis of spherical-shaped rare-earth (Eu(3+) and Tb(3+)) ions doped CaMoO4 nanoparticles in double solvents (IPA and H2O) with the help of autoclave. The X-ray diffraction patterns well match with the standard values and confirm the crystallization in a tetragonal phase with an I41/a (88) space group. The luminescence spectra exhibit the strong red and green emissions from Eu(3+) and Tb(3+) ions doped samples, respectively. The X-ray photoelectron spectroscopy results show the oxidation states of all the elements present in the sample...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28910266/therapeutic-effect-and-mechanism-of-action-of-abnormal-savda-munziq-in-development-of-degenerative-atherosclerotic-aortic-valve-disease
#15
Aisikaer Shabiti, Aili Aibibula, Aikeremu Tuerxun, Halmurat Wufuer
BACKGROUND The aim of this study was to investigate the therapeutic effect of abnormal Savda Munziq (ASMq) on the development of degenerative atherosclerotic aortic valve disease and its underlying mechanisms. MATERIAL AND METHODS We randomly divided 80 rabbits into 4 groups: a normal control group (group N, n=20); a high-fat diet group (group HC, n=20); a high-fat diet and Atorvastatin calcium intervention group (group AI, n=20); and a high-fat diet and ASMq intervention group (group MI, n=20). For evaluation of blood lipid profiles, blood samples were collected at week 0 and at the end of week 8...
September 14, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28905546/-hypertension-in-people-of-african-descent
#16
Fabien Cane, Sofia Zisimopoulou, Antoinette Pechère-Bertschi
Hypertension in people of African descent presents an increased prevalence, an earlier and more severe target organ damage and is harder to control compared to other ethnicities. Preeclampsia and gestational hypertension are more frequent in black women. The physiological phenomenon of night time blood pressure dipping is often blunted. The low renin hypertension phenotype seems to be caused by an increase in sodium retention at renal level. The treatment of choice is calcium channel blockers and thiazide diuretics along with a renin-angiotensin-aldosterone blocker for kidney protection...
September 13, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28904862/t-darpp-is-an-elongated-monomer-that-binds-calcium-and-is-phosphorylated-by-cyclin-dependent-kinases-1-and-5
#17
Jamil Momand, Patrycja Magdziarz, You Feng, Dianlu Jiang, Elizabeth Parga, Arianna Celis, Erin Denny, Xiaoying Wang, Martin L Phillips, Estuardo Monterroso, Susan E Kane, Feimeng Zhou
t-Darpp (truncated isoform of dopamine- and cAMP-regulated phosphoprotein) is a protein encoded by the PPP1R1B gene and is expressed in breast, colon, esophageal, gastric, and prostate cancers, as well as in normal adult brain striatal cells. Overexpression of t-Darpp in cultured cells leads to increased protein kinase A activity and increased phosphorylation of AKT (protein kinase B). In HER2+ breast cancer cells, t-Darpp confers resistance to the chemotherapeutic agent trastuzumab. To shed light on t-Darpp function, we studied its secondary structure, oligomerization status, metal-binding properties, and phosphorylation by cyclin-dependent kinases 1 and 5...
September 2017: FEBS Open Bio
https://www.readbyqxmd.com/read/28904570/bone-mineral-status-in-children-with-epilepsy-biochemical-and-radiologic-markers
#18
Bothina Hasaneen, Riad Moustafa Elsayed, Nanees Salem, Ashraf Elsharkawy, Noha Tharwat, Khaled Fathy, Amany El-Hawary, Hadil M Aboelenin
OBJECTIVE: The aim of this study is to assess bone mineral status in children with epilepsy, on different antiepileptic drugs (AEDs) regimen, using dual-energy X-ray absorptiometry (DXA) and routine biochemical bone markers. PATIENTS AND METHODS: This is observational prospective controlled cohort study, conducted at Mansoura University Children Hospital, from January 2014 to June 2015. In this study, we had 152 participants with ages 3-13 years, 70 children diagnosed with epilepsy and 82 were controls...
April 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/28904232/effects-of-high-versus-moderate-intensity-training-on-neuroplasticity-and-functional-recovery-after-focal-ischemia
#19
Caroline Pin-Barre, Annabelle Constans, Jeanick Brisswalter, Christophe Pellegrino, Jérôme Laurin
BACKGROUND AND PURPOSE: This study was designed to compare the effects of high-intensity interval training (HIT) and moderate-intensity aerobic training (MOD) on functional recovery and cerebral plasticity during the first 2 weeks after cerebral ischemia. METHODS: Rats were randomized as follows: control (n=15), SHAM (n=9), middle cerebral artery occlusion (n=13), middle cerebral artery occlusion at day 1 (n=7), MOD (n=13), and HIT (n=13). Incremental tests were performed at day 1 (D1) and 14 (D14) to identify the running speed associated with the lactate threshold (SLT) and the maximal speed (Smax)...
September 13, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28904112/modeling-the-impact-of-nutrition-interventions-on-birth-outcomes-in-the-lives-saved-tool-list
#20
REVIEW
Rebecca Heidkamp, Adrienne Clermont, Erica Phillips
Background: Negative birth outcomes [small-for-gestational age (SGA) and preterm birth (PTB)] are common in low- and middle-income countries and have important subsequent health and developmental impacts on children. There are numerous nutritional and non-nutritional interventions that can decrease the risk of negative birth outcomes and reduce subsequent risk of mortality and growth faltering.Objective: The objective of this article was to review the current evidence for the impact of nutritional interventions in pregnancy [calcium supplementation, iron and folic acid supplementation, multiple micronutrient (MMN) supplementation, and balanced energy supplementation (BES)] and risk factors (maternal anemia) on birth outcomes, with the specific goal of determining which intervention-outcome linkages should be included in the Lives Saved Tool (LiST) software...
September 13, 2017: Journal of Nutrition
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