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https://www.readbyqxmd.com/read/28721440/selectivity-of-plasma-membrane-calcium-atpase-pmca-mediated-extrusion-of-toxic-divalent-cations-in-vitro-and-in-cultured-cells
#1
Mariela S Ferreira-Gomes, Irene C Mangialavori, Mallku Q Ontiveros, Debora E Rinaldi, Jorge Martiarena, Sandra V Verstraeten, Juan Pablo F C Rossi
In the recent years, the toxicity of certain divalent cations has been associated with the alteration of intracellular Ca(2+) homeostasis. Among other mechanisms, these cations may affect the functionality of certain Ca(2+)-binding proteins and/or Ca(2+) pumps. The plasma membrane calcium pump (PMCA) maintains Ca(2+) homeostasis in eukaryotic cells by mediating the efflux of this cation in a process coupled to ATP hydrolysis. The aim of this work was to investigate both in vitro and in cultured cells if other divalent cations (Sr(2+), Ba(2+), Co(2+), Cd(2+), Pb(2+) or Be(2+)) could be transported by PMCA...
July 18, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28720324/synthesis-and-diabetic-neuropathic-pain-alleviating-effects-of-2n-pyrazol-3-yl-methylbenzo-d-isothiazole-1-1-dioxide-derivatives
#2
Jin Ri Hong, Young Jin Choi, Gyochang Keum, Ghilsoo Nam
A novel series of fused-benzensulfonamide 2-N-(pyrazol-3-yl)methylbenzo[d]isothiazole-1,1-dioxide derivatives was designed and synthesized as metabolically stable T-type calcium channel inhibitors. Several compounds, 9, 10, and 17, displayed potent T-type channel inhibitory activity. Among them, compounds 10 and 17 showed good metabolic stability in human liver microsomes, and low hERG channel and CYP450 inhibition. Compound 10 exhibited diabetic neuropathic pain-alleviating effects in a streptozotocin-induced peripheral diabetic neuropathy (PDN) model...
July 8, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28719612/renal-osteodystrophy-in-the-obesity-era-is-metabolic-syndrome-relevant
#3
Janaina Da Silva Martins, João Henrique Castro, Nestor A Sainz Rueda, Luciene Machado Dos Reis, Vanda Jorgetti, Rosa Maria Affonso Moysés, Jacqueline Teixeira Caramori
BACKGROUND: Observational studies have shown a beneficial effect of obesity on bone health; however, most of those studies were not based on bone biopsies. Metabolic syndrome (MetS) could have an effect on bone remodeling. However, there are no data on the effects of MetS in the presence of renal osteodystrophy. OBJECTIVE: The aim of this study was to investigate associations between MetS and renal osteodystrophy using the bone histomorphometric turnover-mineralization-volume (TMV) classification...
2017: PloS One
https://www.readbyqxmd.com/read/28717990/iron-based-phosphate-binders-a-paradigm-shift-in-the-treatment-of-hyperphosphatemic-anemic-ckd-patients
#4
REVIEW
Francesco Locatelli, Lucia Del Vecchio
The partial correction of anemia and the normalization of phosphate and blood pressure are the mainstay of treatment of patients with chronic kidney disease (CKD). Available anti-hypertensive drugs, erythropoiesis stimulating agents (ESAs) and iron supplements have resolved quite satisfactorily the goal of controlling hypertension and partially correcting anemia. Unfortunately, the treatment of hyperphosphatemia is still far from resolved. Phosphate binders have poor tolerability and/or limited efficacy, leading to the prescription of many tablets that achieve only a mild-to-moderate effect...
July 17, 2017: Journal of Nephrology
https://www.readbyqxmd.com/read/28717111/usefulness-of-cardiotoxicity-assessment-using-calcium-transient-in-human-induced-pluripotent-stem-cell-derived-cardiomyocytes
#5
Hitoshi Watanabe, Yayoi Honda, Jiro Deguchi, Toru Yamada, Kiyoko Bando
Monitoring dramatic changes in intracellular calcium ion levels during cardiac contraction and relaxation, known as calcium transient, in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) would be an attractive strategy for assessing compounds on cardiac contractility. In addition, as arrhythmogenic compounds are known to induce characteristic waveform changes in hiPSC-CMs, it is expected that calcium transient would allow evaluation of not only compound-induced effects on cardiac contractility, but also compound arrhythmogenic potential...
2017: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/28715881/comparison-of-bone-metabolism-based-on-the-different-ages-and-competition-levels-of-junior-and-high-school-female-rhythmic-gymnasts
#6
Taewoong Oh, Tatsuki Naka
PURPOSE: This study was to clarify the effect of age and competition level by measuring bone metabolism markers and bone mineral density measurements of junior high school and high school female rhythmic gymnasts, who restrict their diets to maintain a low body weight, while routinely undertaking long hours of high-intensity exercise, comparing the gymnasts based on their elite/non-elite. METHODS: The study investigated 7 junior high school and 12 high school female rhythmic gymnasts...
June 30, 2017: Journal of Exercise Nutrition & Biochemistry
https://www.readbyqxmd.com/read/28715463/potassium-citrate-prevents-increased-osteoclastogenesis-resulting-from-acidic-conditions-implication-for-the-treatment-of-postmenopausal-bone-loss
#7
Donatella Granchi, Elena Torreggiani, Annamaria Massa, Renata Caudarella, Gemma Di Pompo, Nicola Baldini
The extracellular acidic milieu in bones results in activation of osteoclasts (OC) and inhibition of osteoblasts (OB) causing a net loss of calcium from the skeleton and the deterioration of bone microarchitecture. Alkalinization through supplementation with potassium citrate (K citrate) has been proposed to limit the osteopenia progression, even though its pharmacological activity in bone microenvironment is not well defined. We evaluated if K citrate was able to prevent the adverse effects that acidic milieu induces on bone cells...
2017: PloS One
https://www.readbyqxmd.com/read/28714404/current-and-emerging-strategies-in-osteoporosis-management
#8
Stefka Ivanova, Liliya Vasileva
The abnormal loss of bone tissue is defined as osteoporosis. Increased risk of fractures, low bone mineral density (BMD) and loss of the structural and biomechanical properties of the bone tissue characterize this pathological condition. Physiologically bone undergoes a continuous remodeling process involving balance between the activity of osteoblast and osteoclast. Disruption in this balanced condition increases the risk of osteoporosis. Both sexes are affected, but with higher prevalence in women after menopause...
July 14, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28714191/disordered-conformation-with-low-pii-helix-in-phosphoproteins-orchestrates-biomimetic-apatite-formation
#9
Melika Sarem, Steffen Lüdeke, Ralf Thomann, Pavel Salavei, Zhaoyong Zou, Wouter Habraken, Admir Masic, V Prasad Shastri
The interplay between noncollagenous proteins and biomineralization is widely accepted, yet the contribution of their secondary structure in mineral formation remains to be clarified. This study demonstrates a role for phosvitin, an intrinsically disordered phosphoprotein, in chick embryo skeletal development, and using circular dichroism and matrix least-squares Henderson-Hasselbalch global fitting, unravels three distinct pH-dependent secondary structures in phosvitin. By sequestering phosvitin on a biomimetic 3D insoluble cationic framework at defined pHs, access is gained to phosvitin in various conformational states...
July 17, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28711685/misunderstandings-and-controversies-about-the-insulin-secreting-properties-of-antidiabetic-sulfonylureas
#10
REVIEW
Jean-Claude Henquin
After 60 years of use in the treatment of type 2 diabetes, hypoglycemic sulfonylureas remain a recommended option in current therapeutic charts. Their binding to sulfonylurea receptor-1, the regulatory subunit of ATP-sensitive potassium channels in the plasma membrane of pancreatic β-cells, leads to closure of the channels, membrane depolarization and influx of Ca(2+) through voltage-gated calcium channels. The resulting increase in cytosolic Ca(2+) triggers exocytosis of insulin granules. Sulfonylureas and glucose thus produce the same triggering signal but, unlike sulfonylureas, glucose does so via acceleration of β-cell metabolism...
July 12, 2017: Biochimie
https://www.readbyqxmd.com/read/28711490/long-term-response-to-sunitinib-treatment-in-metastatic-renal-cell-carcinoma-a-pooled-analysis-of-clinical-trials
#11
Nizar M Tannir, Robert A Figlin, Martin E Gore, M Dror Michaelson, Robert J Motzer, Camillo Porta, Brian I Rini, Caroline Hoang, Xun Lin, Bernard Escudier
BACKGROUND: We characterized clinical outcomes of patients with metastatic renal cell carcinoma (mRCC) treated with sunitinib who were long-term responders (LTRs), defined as patients having progression-free survival (PFS) > 18 months. PATIENTS AND METHODS: A retrospective analysis of data from 5714 patients with mRCC treated with sunitinib in 8 phase II/III clinical trials and the expanded access program. Duration on-study and objective response rate (ORR) were compared between LTRs and patients with PFS ≤ 18 months ("others")...
June 20, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28711248/the-effect-of-source-of-supplemental-dietary-calcium-and-magnesium-in-the-peripartum-period-and-level-of-dietary-magnesium-postpartum-on-mineral-status-performance-and-energy-metabolites-in-multiparous-holstein-cows
#12
B M Leno, S E LaCount, C M Ryan, D Briggs, M Crombie, T R Overton
The objective of this study was to determine the effects of feeding different supplemental sources of Ca and Mg in the peripartum period, and different dietary levels of Mg postpartum, on plasma mineral status, performance, and aspects of energy metabolism in transition dairy cows. Multiparous Holstein cows (n = 41) were used in a completely randomized design with a 2 × 2 factorial arrangement of treatments starting at 28 d before expected parturition. Main effects were source assignments (CS = common sources of supplemental Ca and Mg, or MA = a blend of common and commercial mineral sources with supplemental minerals primarily from a commercial Ca-Mg dolomite source; MIN-AD, Papillon Agricultural Company Inc...
July 12, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28710984/aggregation-behavior-of-tio2-nanoparticles-in-municipal-effluent-influence-of-ionic-strengthen-and-organic-compounds
#13
Meijie Ren, Harald Horn, Fritz H Frimmel
The influence of ionic strengthen and dissolved organic matter (DOM) on the aggregation of TiO2 nanoparticles (NPs) in municipal effluent was investigated. The results demonstrated that DOM promoted the mobility of NPs in aquatic system by synergism between static repulsion and steric effect, while electrolytes were opposite by charge-neutralization. The physical-chemical characteristics of DOM played the major role on the mobility of NPs. Bovine serum albumin (BSA) showed the strongest enhancement on the mobility of TiO2 NPs...
July 11, 2017: Water Research
https://www.readbyqxmd.com/read/28710871/detection-and-quantification-of-coronary-calcium-from-dual-energy-chest-x-rays-phantom-feasibility-study
#14
Bo Zhou, Di Wen, Katelyn Nye, Robert C Gilkeson, Brendan Eck, David Jordan, David L Wilson
PURPOSE: We have demonstrated the ability to identify coronary calcium, a reliable biomarker of coronary artery disease, using non-gated, 2-shot, dual energy (DE) chest x-ray imaging. Here we will use digital simulations, backed up by measurements, to characterize DE calcium signals and the role of potential confounds such as beam hardening, x-ray scatter, cardiac motion, and pulmonary artery pulsation. For the DE calcium signal, we will consider quantification, as compared to CT calcium score, and visualization...
July 15, 2017: Medical Physics
https://www.readbyqxmd.com/read/28709293/fluorescence-correlation-spectroscopy-experiments-to-quantify-free-diffusion-coefficients-in-reaction-diffusion-systems-the-case-of-ca-2-and-its-dyes
#15
Lorena Sigaut, Cecilia Villarruel, María Laura Ponce, Silvina Ponce Dawson
Many cell signaling pathways involve the diffusion of messengers that bind and unbind to and from intracellular components. Quantifying their net transport rate under different conditions then requires having separate estimates of their free diffusion coefficient and binding or unbinding rates. In this paper, we show how performing sets of fluorescence correlation spectroscopy (FCS) experiments under different conditions, it is possible to quantify free diffusion coefficients and on and off rates of reaction-diffusion systems...
June 2017: Physical Review. E
https://www.readbyqxmd.com/read/28708907/local-application-of-growth-hormone-to-enhance-osseointegration-in-osteoporotic-bones-a-morphometric-and-densitometric-study
#16
Elena Martin-Monge, Isabel F Tresguerres, Celia Clemente, Jesús Af Tresguerres
PURPOSE: The aim of this study was to assess the effect of local application of growth hormone on osseointegration of dental implants inserted in osteoporotic bones. MATERIALS AND METHODS: Twenty female New Zealand rabbits were used in this study. Ten were ovariectomized and fed a low-calcium diet for 6 weeks, and the others remained intact. A titanium implant was inserted into each tibia, in both groups. In half of the rabbits, 2 IU of growth hormone was placed into the ostectomy prior to the implant insertion...
July 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28708858/oscngc13-promotes-seed-setting-rate-by-facilitating-pollen-tube-growth-in-stylar-tissues
#17
Yang Xu, Jie Yang, Yihua Wang, Jiachang Wang, Yang Yu, Yu Long, Yunlong Wang, Huan Zhang, Yulong Ren, Jun Chen, Ying Wang, Xin Zhang, Xiuping Guo, Fuqing Wu, Shanshan Zhu, Qibing Lin, Ling Jiang, Chuanyin Wu, Haiyang Wang, Jianmin Wan
Seed-setting rate is a critical determinant of grain yield in rice (Oryza sativa L.). Rapid and healthy pollen tube growth in the style is required for high seed-setting rate. The molecular mechanisms governing this process remain largely unknown. In this study, we isolate a dominant low seed-setting rate rice mutant, sss1-D. Cellular examination results show that pollen tube growth is blocked in about half of the mutant styles. Molecular cloning and functional assays reveals that SSS1-D encodes OsCNGC13, a member of the cyclic nucleotide-gated channel family...
July 14, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28705682/increased-bone-matrix-mineralization-in-treatment-na%C3%A3-ve-children-with-inflammatory-bowel-disease
#18
Barbara M Misof, Paul Roschger, Klaus Klaushofer, Frank Rauch, Jinhui Ma, David R Mack, Leanne M Ward
Inflammatory bowel disease (IBD) affects many organ systems including the skeleton. In children with IBD, bone mineral density (BMD) and bone turnover are frequently low. Disturbances in bone mineralization density distribution (BMDD) are linked to alterations in bone material strength; however, BMDD has not previously been reported in children with chronic inflammatory disorders. The aim of this study was to characterize BMDD based on quantitative backscatter electron imaging in cancellous (Cn.) and cortical (Ct...
July 10, 2017: Bone
https://www.readbyqxmd.com/read/28704427/the-influence-of-human-exploration-on-the-microbial-community-structure-and-ammonia-oxidizing-potential-of-the-su-bentu-limestone-cave-in-sardinia-italy
#19
Stefan Leuko, Kaisa Koskinen, Laura Sanna, Ilenia M D'Angeli, Jo De Waele, Paolo Marcia, Christine Moissl-Eichinger, Petra Rettberg
The bacterial diversity in the Su Bentu Cave in Sardinia was investigated by means of 16S rRNA gene-based analysis. This 15 km long cave, carved in Jurassic limestone, hosts a variety of calcite speleothems, and a long succession of subterranean lakes with mixed granite and carbonate sands. The lower level is occasionally flooded by a rising groundwater level, but with only scarce input of organic remains (leaves and charcoal fragments). On the quiet cave pools there are visible calcite rafts, whereas walls are locally coated with manganese deposits...
2017: PloS One
https://www.readbyqxmd.com/read/28703639/physicochemical-regulation-of-tgf-and-vegf-delivery-from-mesoporous-calcium-phosphate-bone-substitutes
#20
Janina Möller-Siegert, Julien Parmentier, Patrice Laquerrière, Ali Ouadi, Olivier Raisslé, Edouard Jallot, Jean-Marie Nedelec, Cathie Vix-Guterl, Karine Anselme
AIM: Determination of the physicochemical parameters governing growth factors (GFs) adsorption and release from mesoporous calcium phosphate ceramics. MATERIALS & METHODS: Six mesoporous calcium phosphate ceramics prepared by soft and hard templating were loaded with two different physiological concentrations of TGF-β1 or VEGF165 and their in vitro kinetics of adsorption/release were studied. RESULTS: This low GF loading promotes adsorption on the highest binding sites...
July 13, 2017: Nanomedicine
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