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https://www.readbyqxmd.com/read/28817814/cardiac-computed-tomography-angiographic-findings-as-predictors-of-late-heart-failure-in-an-asymptomatic-diabetic-cohort-an-8-year-prospective-follow-up-study
#1
David A Halon, Jubran Ayman, Ronen Rubinshtein, Barak Zafrir, Mali Azencot, Basil S Lewis
OBJECTIVES: Predictive models for heart failure (HF) in heterogeneous populations have had limited success. We examined cardiac computed tomography angiography (CTA) predictors of HF or cardiovascular death (HF-CVD) in a prospective study of asymptomatic diabetics undergoing baseline assessment by CTA. METHODS: The subjects (n = 735, aged 55-74 years, 51.2% women) had no clinical history of cardiovascular disease at study entry. Coronary artery calcium (CAC) score, CTA-defined coronary atherosclerosis, cardiac chamber volumes, and clinical data were collected and late outcome events recorded over 8...
August 18, 2017: Cardiology
https://www.readbyqxmd.com/read/28817665/concentrations-of-trace-elements-in-human-milk-comparisons-among-women-in-argentina-namibia-poland-and-the-united-states
#2
Laura D Klein, Alicia A Breakey, Brooke Scelza, Claudia Valeggia, Grazyna Jasienska, Katie Hinde
Human milk contains essential micronutrients for growth and development during early life. Environmental pollutants, such as potentially toxic metals, can also be transferred to the infant through human milk. These elements have been well-studied, but changing diets and environments and advances in laboratory technology require re-examining these elements in a variety of settings. The aim of this study was to characterize the concentrations of essential and toxic metals in human milk from four diverse populations...
2017: PloS One
https://www.readbyqxmd.com/read/28815389/spine-bone-mineral-density-increases-after-6%C3%A2-months-of-exclusive-lactation-even-in-women-who-keep-breastfeeding
#3
Sandra Cooke-Hubley, Beth J Kirby, James E Valcour, Gerald Mugford, Jonathan D Adachi, Christopher S Kovacs
This pilot study enrolled 31 women who had breastfed exclusively for 6 months. Lumbar and thoracic BMD increased 4 and 5%, respectively. Femoral neck and total body BMD did not change. Return of menses and progestin-only pill use were two potential signals that predicted a greater increase in BMD. PURPOSE/INTRODUCTION: The skeleton is resorbed during lactation to provide much of the calcium content of milk. After lactation ceases, these deficits in skeletal mineral content are largely restored, such that lactation has a neutral or protective effect against the long-term risk of low bone mineral density (BMD), osteoporosis, and fragility fractures...
August 16, 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28814903/ixeris-dentata-extract-regulates-salivary-secretion-through-the-activation-of-aquaporin-5-and-prevents-diabetes-induced-xerostomia
#4
Kashi Raj Bhattarai, Sang-Won Lee, Seung Hyun Kim, Hyung-Ryong Kim, Han-Jung Chae
The aim of this study was to investigate the effects of Ixeris dentata (IXD) extract to improve the salivation rate in dry mouth induced by diabetes. Both control and diabetic rats were treated with a sublingual spray of either water or IXD extract to determine the effects of IXD on salivation. During the study, we observed that IXD extract treatment increased the salivary flow rate in diabetic rats. The expression of α-amylase was increased significantly in both saliva and glandular tissue lysates of IXD-treated diabetic rats...
2017: Journal of Experimental Pharmacology
https://www.readbyqxmd.com/read/28814603/single-nucleotide-polymorphisms-of-the-high-affinity-igg-receptor-fc%C3%AE-ri-reduce-immune-complex-binding-and-downstream-effector-functions
#5
Arianne M Brandsma, Toine Ten Broeke, Evelien van Dueren den Hollander, Thomas G Caniels, Tineke Kardol-Hoefnagel, Jürgen Kuball, Jeanette H W Leusen
Binding of IgG Abs to FcγRs on immune cells induces FcγR cross-linking that leads to cellular effector functions, such as phagocytosis, Ab-dependent cellular cytotoxicity, and cytokine release. However, polymorphisms in low affinity FcγRs have been associated with altered avidity toward IgG, thereby substantially impacting clinical outcomes of multimodular therapy when targeting cancer or autoimmune diseases with mAbs as well as the frequency and severity of autoimmune diseases. In this context, we investigated the consequences of three nonsynonymous single nucleotide polymorphisms (SNPs) for the high affinity receptor for IgG, FcγRI...
August 16, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28811999/quantitative-analysis-of-epicardial-fat-volume-effects-of-scanning-protocol-and-reproducibility-of-measurements-in-non-contrast-cardiac-ct-vs-coronary-ct-angiography
#6
Luigia D'Errico, Francesco Salituri, Marco Ciardetti, Riccardo Favilla, Alessandro Mazzarisi, Giuseppe Coppini, Carlo Bartolozzi, Paoli Marraccini
BACKGROUND: Several studies have focused on the role of epicardial fat in the pathogenesis of cardiovascular disease (CVD). The main purpose of the study was to evaluate a computerized method for the quantitative analysis of epicardial fat volume (EFV) by non-contrast cardiac CT (NCT) for coronary calcium scan and coronary CT angiography (coronary CTA). METHODS: Thirty patients (61±12.5 years, 73% male, body mass index (BMI) =25.9±6.3 kg/m(2)) referred to our Institution for suspected coronary artery disease (CAD) underwent NCT and coronary CTA...
June 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28811853/effects-of-sevelamer-hydrochloride-on-uremic-toxins-serum-indoxyl-sulfate-and-p-cresyl-sulfate-in-hemodialysis-patients
#7
Cheng-Jui Lin, Chi-Feng Pan, Chih-Kuang Chuang, Hsuan-Liang Liu, Sung-Fa Huang, Han-Hsiang Chen, Chih-Jen Wu
BACKGROUND: Beside the phosphate binding effect, non-calcium non-aluminum phosphate binder, namely sevelamer hydrochloride (SH), has many other effects in dialysis patients. It can absorb many other compounds, decrease low-density lipoprotein cholesterol (LDL-C) level, and attenuate the progression of vascular calcification; it has been reported to have anti-inflammatory effect. However, it is not clear whether it has any effect on uremic toxins, i.e. serum indoxyl sulfate (IS) and p-cresyl sulfate, (PCS) in hemodialysis (HD) patients...
September 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28810916/the-catsper-channel-and-its-roles-in-male-fertility-a-systematic-review
#8
REVIEW
Xiang-Hong Sun, Ying-Ying Zhu, Lin Wang, Hong-Ling Liu, Yong Ling, Zong-Li Li, Li-Bo Sun
The Catsper channel is a sperm-specific, Ca(2+)-permeable, pH-dependent, and low voltage-dependent channel that is essential for the hyperactivity of sperm flagellum, chemotaxis towards the egg, capacitation and acrosome reaction. All of these physiological events require calcium entry into sperm cells. Remarkably, Catsper genes are exclusively expressed in the testis during spermatogenesis, and are sensitive to ion channel-induced pH change, such as NHEs, Ca(2+)ATPase, K(+) channel, Hv1 channel and HCO3(-) transporters...
August 15, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28810912/inhibition-of-trpm7-suppresses-cell-proliferation-of-colon-adenocarcinoma-in-vitro-and-induces-hypomagnesemia-in-vivo-without-affecting-azoxymethane-induced-early-colon-cancer-in-mice
#9
Junhao Huang, Hideki Furuya, Malika Faouzi, Zheng Zhang, Mahealani Monteilh-Zoller, F Kelly Galbraith Kawabata, David Horgen, Toshihiko Kawamori, Reinhold Penner, Andrea Fleig
BACKGROUND: Magnesium (Mg(2+)) is an essential cation implicated in carcinogenesis, solid tumor progression and metastatic potential. The Transient Receptor Potential Melastatin Member 7 (TRPM7) is a divalent ion channel involved in cellular and systemic Mg(2+) homeostasis. Abnormal expression of TRPM7 is found in numerous cancers, including colon, implicating TRPM7 in this process. METHODS: To establish a possible link between systemic magnesium (Mg(2+)) status, the Mg(2+) conducting channel TRPM7 in colon epithelial cells, and colon carcinogenesis, in vitro whole-cell patch clamp electrophysiology, qPCR, and pharmacological tools were used probing human colorectal adenocarcinoma HT-29 as well as normal primary mouse colon epithelial cells...
August 15, 2017: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/28808885/the-association-of-epicardial-fat-volume-with-coronary-characteristics-and-clinical-outcome
#10
Kohichiro Iwasaki, Norio Urabe, Atsushi Kitagawa, Toshihiko Nagao
Recent studies have demonstrated the relationship between epicardial fat volume (EFV) and coronary atherosclerosis, but their association is modest at best. Our purpose is to elucidate the association of epicardial fat with coronary characteristics and clinical outcome. We performed coronary computed tomographic angiography in 651 patients and divided them into three groups according to tertiles of EFV; low-tertile (n = 215), 36-123 ml; middle-tertile (n = 218), 124-165 ml; high-tertile (n = 218), 166-489 ml...
August 14, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28808858/vitamin-d-and-heart-failure
#11
REVIEW
D Marshall Brinkley, Omair M Ali, Sandip K Zalawadiya, Thomas J Wang
PURPOSE: Vitamin D is principally known for its role in calcium homeostasis, but preclinical studies implicate multiple pathways through which vitamin D may affect cardiovascular function and influence risk for heart failure. Many adults with cardiovascular disease have low vitamin D status, making it a potential therapeutic target. We review the rationale and potential role of vitamin D supplementation in the prevention and treatment of chronic heart failure. RECENT FINDINGS: Substantial observational evidence has associated low vitamin D status with the risk of heart failure, ventricular remodeling, and clinical outcomes in heart failure, including mortality...
August 14, 2017: Current Heart Failure Reports
https://www.readbyqxmd.com/read/28808463/micro-push-out-bond-strength-and-bioactivity-analysis-of-a-bioceramic-root-canal-sealer
#12
Ceci Nunes Carvalho, Renata Grazziotin-Soares, George Táccio de Miranda Candeiro, Luis Gallego Martinez, Juliana Pereira de Souza, Patrícia Santos Oliveira, José Bauer, Giulio Gavini
INTRODUCTION: Bioactive endodontic sealers have been developed to improve the quality of root canal obturation. EndoSequence Bioceramic (BC) Sealer is amongst calcium silicate-based materials recently developed for permanent root canal filling. The objective of this study was to evaluate the bioactivity of BC Sealer and its micro push-out bond strength to dentin compared to AH-Plus (AH) sealer. METHODS AND MATERIALS: To perform the micro push-out test, 24 root canals of mandibular premolars were instrumented and divided into two groups (n=12)...
2017: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/28806302/surgery-for-primary-hyperparathyroidism-adherence-to-consensus-guidelines-in-an-academic-health-system
#13
Eric J Kuo, Mostafa A Al-Alusi, Lin Du, Albert Shieh, Masha J Livhits, Angela M Leung, Michael W Yeh
OBJECTIVE: To determine the extent to which consensus guidelines for surgery in patients with primary hyperparathyroidism (PHPT) are followed within an academic health system. BACKGROUND: Previous studies have shown that adherence to consensus guidelines in community practice is low. METHODS: Adults with biochemically confirmed PHPT who received primary care within an academic health system were identified from 2005 to 2015. Multivariable logistic regression was used to analyze predictors of parathyroidectomy (PTx)...
August 11, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28806048/electrolytes-calcium-disorders
#14
Craig Barstow
A normal serum calcium level is 8 to 10 mg/dL. The diagnosis of hypercalcemia (ie, levels 10.5 mg/dL or greater) should be confirmed with an albumin-adjusted or ionized calcium level. The two most common causes of hypercalcemia are hyperparathyroidism and malignancy. Drugs, notably lithium and thiazide diuretics, also can cause hypercalcemia. Patients with severe or symptomatic hypercalcemia should be treated initially with hydration to decrease calcium levels. The evaluation should include a parathyroid hormone (PTH) level...
August 2017: FP Essentials
https://www.readbyqxmd.com/read/28803421/quantitative-coronary-plaque-analysis-predicts-high-risk-plaque-morphology-on-coronary-computed-tomography-angiography-results-from-the-romicat-ii-trial
#15
Ting Liu, Pál Maurovich-Horvat, Thomas Mayrhofer, Stefan B Puchner, Michael T Lu, Khristine Ghemigian, Pieter H Kitslaar, Alexander Broersen, Amit Pursnani, Udo Hoffmann, Maros Ferencik
Semi-automated software can provide quantitative assessment of atherosclerotic plaques on coronary CT angiography (CTA). The relationship between established qualitative high-risk plaque features and quantitative plaque measurements has not been studied. We analyzed the association between quantitative plaque measurements and qualitative high-risk plaque features on coronary CTA. We included 260 patients with plaque who underwent coronary CTA in the Rule Out Myocardial Infarction/Ischemia Using Computer Assisted Tomography (ROMICAT) II trial...
August 12, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28803343/sediment-lipid-biomarkers-record-phytoplankton-dynamics-of-lake-heihai-yunnan-province-sw-china-driven-by-climate-warming-since-the-1980s
#16
Yongdong Zhang, Yaling Su, Zhengwen Liu, Jinlei Yu, Miao Jin
Increased phosphorus (P) export from sediments to the overlying water column is a significant factor driving the variation of phytoplankton in productivity and community structure in lakes. However, the lack of long-term instrumental data often impeded analyses attempting to associate dynamics of phytoplankton with variation of internal P loading. Here, elements and lipid biomarkers were analyzed in a sediment core from Lake Heihai, a small, deep, and ultraoligotrophic alpine lake in Haba Mountain, Yunnan Province, SW China...
August 12, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28803191/enhancing-recovery-of-magnesium-as-struvite-from-landfill-leachate-by-pretreatment-of-calcium-with-simultaneous-reduction-of-liquid-volume-via-forward-osmosis
#17
Simiao Wu, Shiqiang Zou, Guannan Liang, Guangren Qian, Zhen He
Landfill leachate contains substances that can be potentially recovered as valuable resources. In this study, magnesium in a landfill leachate was recovered as struvite with calcium pretreatment; meanwhile, the leachate volume was reduced by using a submerged forward osmosis (FO) process, thereby enabling significant reduction of further treatment footprint and cost. Without pretreatment, calcium exhibited strong competition for phosphate with magnesium. The pretreatment with a Ca(2+): CO3(2-) molar ratio of 1:1...
August 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28803188/remediation-of-internal-phosphorus-loads-with-modified-clays-influence-of-fluvial-suspended-particulate-matter-and-response-of-the-benthic-macroinvertebrate-community
#18
Hongbin Yin, Grant B Douglas, Yongjiu Cai, Cheng Liu, Diego Copetti
Clay-based phosphorus (P) sorbents have been increasingly used as geoengineering materials for the management sediment-derived internal P loading in eutrophic lakes. However, the long-term behavior of these sorbents has remained elusive along with their response to burial under suspended particulate matter (SPM), and their effect on macroinvertebrate communities occupying dynamic regions at the sediment-water interface of shallow and turbid lakes. In this study, field mesocosm experiments were undertaken in Lake Chaohu, China, to study the effects of the application of lanthanum-modified bentonite (LMB) and thermally-modified calcium-rich attapulgite (TCAP) on sediment internal P loading and to assess their influence on macroinvertebrate community structure...
August 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28801997/prevalence-of-low-bone-mass-among-adolescents-with-nontransfusion-dependent-hemoglobin-e-%C3%AE-thalassemia-and-its-relationship-with-anemia-severity
#19
Pairunyar Nakavachara, Jaturat Petchkul, Krittha Jeerawongpanich, Pornpimol Kiattisakthavee, Teerarat Manpayak, Parichat Netsakulnee, Katharee Chaichanwattanakul, Julaporn Pooliam, Somdet Srichairatanakool, Vip Viprakasit
BACKGROUND: Low bone mass is common among adolescents with transfusion-dependent β-thalassemia despite adequate transfusion and iron chelation. However, there are few reports regarding bone mineral density (BMD) among adolescents with nontransfusion-dependent thalassemia (NTDT). Indeed, only BMD data in patients with nontransfusion-dependent (NTD) β-thalassemia intermedia have been reported. No previous study has investigated BMD among adolescents with NTD hemoglobin (Hb) E/β-thalassemia...
August 12, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28801918/motion-compensation-in-the-region-of-the-coronary-arteries-based-on-partial-angle-reconstructions-from-short-scan-ct-data
#20
Juliane Hahn, Herbert Bruder, Christopher Rohkohl, Thomas Allmendinger, Karl Stierstorfer, Thomas Flohr, Marc Kachelrieß
PURPOSE: In order to mitigate motion-induced artifacts, several motion compensation (MoCo) methods have been developed, which are either able to a) compensate for severe artifacts, but utilize the data for the reconstruction of several cardiac phases, or b) improve image quality of a single reconstruction with only moderate motion artifacts. We propose a method combining both benefits: dose efficiency by utilizing only the data needed for a single short-scan reconstruction while still being able to compensate for severe artifacts...
August 12, 2017: Medical Physics
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