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https://www.readbyqxmd.com/read/29470777/pleiotropic-effects-of-heparins-does-anticoagulant-treatment-increase-survival-in-cancer-patients
#1
REVIEW
I García-Escobar, C Beato-Zambrano, J Muñoz Langa, E Brozos Vázquez, B Obispo Portero, D Gutiérrez-Abad, A J Muñoz Martín
The association between venous thromboembolism (VTE) and cancer has been recognized for more than 100 years. Numerous studies have been performed to investigate strategies to decrease VTE incidence and to establish whether treating VTE impacts cancer progression and overall survival. Accordingly, it is important to understand the role of the hemostatic system in tumorigenesis and progression, as there is abundant evidence associating it with cell survival and proliferation, tumor angiogenesis, invasion, and dissemination, and metastasis formation...
February 22, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29470364/resistance-training-is-associated-with-higher-bone-mineral-density-among-young-adult-male-distance-runners-independent-of-physiological-factors
#2
Anthony A Duplanty, Danielle E Levitt, David W Hill, Brian K McFarlin, Nancy M DiMarco, Jakob L Vingren
Low bone mineral density (BMD) in male distance runners is common and could be modulated by a host of biomarkers involved in the dynamic balance of bone tissue. In contrast, resistance training can increase BMD; however, the efficacy of resistance training in protecting BMD in distance runners has not been elucidated. OBJECTIVE: To investigate the relationship between resistance training, testosterone and bone metabolism biomarker concentrations, and BMD in young adult male distance runners...
February 20, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29469965/vitamin-d-receptor-expression-in-dogs
#3
J A Cartwright, A G Gow, E Milne, D Drummond, S Smith, I Handel, R J Mellanby
BACKGROUND: There is growing evidence linking low blood vitamin D concentration to numerous diseases in people and in dogs. Vitamin D influences cellular function by signaling through the vitamin D receptor (VDR). Little is known about which non-skeletal tissues express the VDR or how inflammation influences its expression in the dog. OBJECTIVES: To define which non-skeletal canine tissues express the VDR and to investigate expression in inflamed small intestine...
February 22, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29467039/influence-of-lifestyle-characteristics-and-vdr-polymorphisms-as-risk-factors-for-intervertebral-disc-degeneration-a-case-control-study
#4
Luiz Angelo Vieira, Aline Amaro Dos Santos, Carla Peluso, Caio Parente Barbosa, Bianca Bianco, Luciano Miller Reis Rodrigues
BACKGROUND: Intervertebral disc degeneration (DD) is an important cause of low back pain and its precise aetiology is not fully understood, being attributed to cumulative environmental, biomechanical and genetic effects. The vitamin D plays a key role in regulation of calcium homeostasis and bone mineralization, exerting its biological activities by binding to a high-affinity receptor (VDR). Polymorphisms in VDR gene were previously associated with DD process, however with conflicting results...
February 21, 2018: European Journal of Medical Research
https://www.readbyqxmd.com/read/29465575/impact-of-vitamin-d-receptor-and-binding-protein-gene-polymorphisms-in-clinical-and-laboratory-data-of-hcv-patients-cross-sectional-study
#5
Letícia de Paula Scalioni, Betânia Rodrigues Dos Santos, Poli Mara Spritzer, Cristiane Alves Villela-Nogueira, Lia Laura Lewis-Ximenez, Priscila Pollo-Flores, Eliane Bordalo Cathalá Esberard, Carlos Eduardo Brandão-Mello, Elisabeth Lampe, Livia Melo Villar
Potential relationship of vitamin D, vitamin D receptor (VDR), and vitamin D binding protein (DBP) have been suggested in the pathophysiology of hepatitis C virus (HCV) infection. The aim of this observational study is to determine vitamin D levels, and VDR and DBP genetic polymorphism according demographic and laboratory data in chronic HCV patients (CHC).A total of 148 CHC patients gave serum samples for testing 25-hydroxyvitamin D (25 (OH)D) level by immunochemiluminometric assay (<20 ng/mL defined as deficient) and donated blood samples to allelic discrimination analysis using TaqMan assays...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29465424/nutritional-approach-to-preeclampsia-prevention
#6
Najate Achamrah, Agnès Ditisheim
PURPOSE OF REVIEW: Although not fully understood, the physiopathology of preeclampsia is thought to involve abnormal placentation, diffuse endothelial cell dysfunction and increased systemic inflammation. As micronutrients play a key role in placental endothelial function, oxidative stress and expression of angiogenic factors, periconceptional micronutrient supplementation has been proposed to reduce the risk of preeclampsia. However, recent studies reported conflicting results. RECENT FINDINGS: Calcium intake (>1 g/day) may reduce the risk of preeclampsia in women with low-calcium diet...
February 19, 2018: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/29462926/do-current-fortification-and-supplementation-programs-assure-adequate-intake-of-fat-soluble-vitamins-in-belgian-infants-toddlers-pregnant-women-and-lactating-women
#7
Isabelle Moyersoen, Carl Lachat, Koenraad Cuypers, Karin De Ridder, Brecht Devleesschauwer, Jean Tafforeau, Stefanie Vandevijvere, Margot Vansteenland, Bruno De Meulenaer, John Van Camp, Herman Van Oyen
Abstracts: Adequate intakes of fat-soluble vitamins are essential to support the growth and development of the foetus, the neonate, and the young child. By means of an online self-administered frequency questionnaire, this study aimed to evaluate the intake of vitamins A, D, E, and K in Belgian infants ( n = 455), toddlers ( n = 265), pregnant women ( n = 161), and lactating women ( n = 165). The contribution of foods, fortified foods, and supplements on the total intake was quantified. 5% of toddlers, 16% of pregnant women, and 35% of lactating women had an inadequate vitamin A intake...
February 16, 2018: Nutrients
https://www.readbyqxmd.com/read/29462382/prediagnostic-serum-vitamin-d-levels-and-the-risk-of-crohn-s-disease-and-ulcerative-colitis-in-european-populations-a-nested-case-control-study
#8
Jorrit L Opstelten, Simon S M Chan, Andrew R Hart, Fiona D M van Schaik, Peter D Siersema, Eef G W M Lentjes, Kay-Tee Khaw, Robert Luben, Timothy J Key, Heiner Boeing, Manuela M Bergmann, Kim Overvad, Domenico Palli, Giovanna Masala, Antoine Racine, Franck Carbonnel, Marie-Christine Boutron-Ruault, Anne Tjønneland, Anja Olsen, Vibeke Andersen, Rudolf Kaaks, Tilman Kühn, Rosario Tumino, Antonia Trichopoulou, Petra H M Peeters, W M Monique Verschuren, Ben J M Witteman, Bas Oldenburg
Background: A low vitamin D status has been put forward as a potential risk factor for the development of inflammatory bowel disease (IBD). This study investigated the association between prediagnostic circulating vitamin D concentrations and dietary intakes of vitamin D, and the risk of Crohn's disease (CD) and ulcerative colitis (UC). Methods: Among 359,728 participants of the European Prospective Investigation into Cancer and Nutrition cohort, individuals who developed CD or UC after enrollment were identified...
February 15, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29460820/association-between-mental-disorders-cognitive-disturbances-and-vitamin-d-serum-level-current-state
#9
Paul P Lerner, Laura Sharony, Chanoch Miodownik
BACKGROUND & AIMS: Vitamin D deficiency has been identified as a global problem. Approximately 14% of the world population has inadequate vitamin D levels. This vitamin has been usually associated with bone disorders such as rickets, osteomalacia, and osteoporosis. However, these disorders present only a small part of all the disturbances which can be induced by its deficiency. Low serum vitamin D is associated with development of cardiovascular diseases, hypertension, neurodegenerative diseases, diabetes mellitus, metabolic syndrome and even cancer...
February 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29460819/effect-of-high-dose-vitamin-d3-therapy-on-serum-vitamin-d3-levels-in-vitamin-d-insufficient-adults-with-cystic-fibrosis
#10
Rhiza Regalado Lam Chew Tun, Nancy Porhownik, Shayne Taback, Curtis Oleschuk
BACKGROUND: The effect of a high dose oral cholecalciferol repletion strategy in Vitamin D insufficient adults with CF is still unknown. Therefore, we assessed the effectiveness of our current approach, giving oral vitamin D3 supplementation at a dose of 10,000 IU from Monday to Friday for a total of 50,000 IU D3 weekly in vitamin D insufficient adult with CF. METHODS: We performed a retrospective chart review of all 59 adult CF patients between the ages of 17 and 64 years routinely followed at the CF Adult Program of Winnipeg Health Sciences Centre...
February 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29460803/vitamin-d-status-in-children-with-headache-a-case-control-study
#11
A Donmez, E Orun, F M Sonmez
BACKGROUND: Vitamin D is a fat soluble vitamin with hormonal properties, plays crucial functions in bone and mineral metabolism and has important regulatory functions in brain development, cell differentiation and apoptosis. Some studies have shown a link between vitamin D deficiency and headache. MATERIAL AND METHODS: In this study, 147 patients with headache (migraine or either tension-type headache (TTH)) and 69 healthy controls, aged 5 to 16 years, were evaluated...
February 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29458928/adjunctive-vitamin-d-in-the-treatment-of-non-remitted-depression-lessons-from-a-failed-clinical-trial
#12
Monique Aucoin, Kieran Cooley, Leena Anand, Melissa Furtado, Alex Canzonieri, Alexa Fine, Kathryn Fotinos, Ranjith Chandrasena, Larry J Klassen, Irvin Epstein, Wende Wood, Martin A Katzman
BACKGROUND: Many patients with depression fail to achieve remission after several consecutive treatments. Vitamin D deficiency is prevalent and new research suggests that it may have an impact on mood, primarily through an effect on neurotransmitters. Numerous observational studies suggest a relationship between low levels of vitamin D and increased incidence and severity of mood disorders. A small number of pilot studies have been undertaken but lack rigorous methodology required to draw conclusions about a clinical role for this nutrient in treatment resistant depression...
February 2018: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/29458876/bone-densitometry-status-and-its-associated-factors-in-peri-and-post-menopausal-females-a-cross-sectional-study-from-a-tertiary-care-centre-in-india
#13
Jaya Chawla, Neena Sharma, Devendra Arora, Manisha Arora, Lovely Shukla
OBJECTIVE: Osteoporosis is a skeletal disorder characterized by diminished bone strength that increases the risk of fracture at instances of trivial trauma. Asians have a lower bone mass than the west. The present study was designed to add data from India on women above the age of 40 years with respect to low bone mineral density (BMD) and its associated high risk factors. MATERIALS AND METHODS: After a written informed consent, a detailed history was taken. Basal metabolic index was recorded, and biochemical and endocrine tests were done, followed by dual X ray absorptiometry scan...
February 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29457224/factors-associated-with-nutritional-status-and-dietary-practices-of-bangladeshi-adolescents-in-early-pregnancy
#14
Malay K Mridha, Susana L Matias, Charles D Arnold, Kathryn G Dewey
Bangladesh has a high prevalence of adolescent pregnancy, but little is known about the nutritional status and dietary practices of Bangladeshi adolescents in early pregnancy or associated factors. We used the baseline data of 1552 pregnant adolescents from a longitudinal, cluster-randomized effectiveness trial conducted in northwest Bangladesh. Forty-four percent of the adolescents were short for their age, 36% had low body mass index, 28% were anemic, 10% had iron deficiency, and 32% had vitamin A deficiency...
February 18, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29456691/different-doses-of-folic-acid-and-vitamin-b12-to-treat-rabbits-with-deep-venous-thrombosis-and-hyperhomocysteinemia
#15
Xiao-Jun Shu, Zheng-Fei Li, Yao-Wen Chang, Sheng-Ye Liu, Wen-Hui Wang, Xiaoqiang Li
The effects of different doses of folic acid and vitamin B12 on rabbits with deep vein thrombosis (DVT) and hyperhomocysteinemia were investigated. In total, 60 New Zealand rabbits were divided into untreated control, low-dose and high-dose groups. After inducing DVT, hemorheology and coagulation indexes were measured 3 and 10 days later. We found that both treatment groups performed better than the control group, and the high-dose performed better than the low-dose. Ten days after thrombosis, the levels of Hcy and D-dimer were lower in the high-dose group...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29456394/assessment-of-vitamin-d-in-rheumatoid-arthritis-and-its-correlation-with-disease-activity
#16
Narendra Meena, Sumit Pal Singh Chawla, Ravinder Garg, Anil Batta, Sarabjot Kaur
Background: Vitamin D is believed to have an immunomodulatory and anti-inflammatory action, and its deficiency has been linked with several autoimmune disorders, including rheumatoid arthritis (RA). The relationship between the severity of RA and serum levels of Vitamin D is a subject of immense interest and therapeutic implications. Materials and Methods: This was a prospective, comparative study conducted on 100 participants, 50 cases of RA and 50 healthy controls, all in the age group of 18-75 years...
January 2018: Journal of Natural Science, Biology, and Medicine
https://www.readbyqxmd.com/read/29453514/prevalence-and-determinants-of-vitamin-d-deficiency-among-the-overweight-and-obese-singaporeans-seeking-weight-management-including-bariatric-surgery-a-relationship-with-bone-health
#17
Marc Weijie Ong, Chun Hai Tan, Anton Kui Sing Cheng
PURPOSE: Low vitamin D status is prevalent worldwide and has been linked to a variety of pathologies including obesity in adults. The severity of vitamin D deficiency amongst the overweight and obese Singaporeans is not well documented. The purpose of this prospective observational study was to assess the prevalence and determinants of vitamin D deficiency in a multi-ethnic Asian population referred for weight management, including those seeking bariatric surgery. MATERIALS AND METHODS: This was a cross-sectional study conducted among 111 consecutive subjects referred to a single institution weight management service in Singapore...
February 16, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29449827/sun-exposure-across-the-life-course-significantly-modulates-early-multiple-sclerosis-clinical-course
#18
Steve Simpson, Ingrid van der Mei, Robyn M Lucas, Anne-Louise Ponsonby, Simon Broadley, Leigh Blizzard, Bruce Taylor
Background: Low vitamin D and/or sun exposure have been associated with increased risk of multiple sclerosis (MS) onset. However, comparatively, few studies have prospectively examined associations between these factors and clinical course. Objectives: To evaluate the association of sun exposure parameters and vitamin D levels with conversion to MS and relapse risk in a prospectively monitored cohort of 145 participants followed after a first demyelinating event up to 5-year review (AusLong Study)...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29448922/a-randomised-control-crossover-trial-of-a-theory-based-intervention-to-improve-sun-safe-and-healthy-behaviours-in-construction-workers-study-protocol
#19
Amanda Nioi, Charlotte Wendelboe-Nelson, Sue Cowan, Hilary Cowie, Shahzad Rashid, Peter Ritchie, Mark Cherrie, Terry C Lansdown, John W Cherrie
BACKGROUND: Exposure to sunlight can have both positive and negative health impacts. Excessive exposure to ultra-violet (UV) radiation from the sun can cause skin cancer, however insufficient exposure to sunlight has a detrimental effect on production of Vitamin D. In the construction industry there are onsite proactive behaviours for safety, but sun-safety remains a low priority. There is limited research on understanding the barriers to adopting sun-safe behaviours and the association this may have with Vitamin D production...
February 15, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29447929/a-complex-systems-approach-to-cancer-prevention
#20
P W Jupp
Cancer incidence continues to be a major health problem possibly because cancer is a complex system comprising many agents that interact in a non-linear manner resulting in many possible outcomes. The degree of complexity of a cancer system could be vast involving multiple endogenous and exogenous agents interacting with the over 10 trillion cells comprising the body. It is hypothesized that the practical management of this complexity may be a key to cancer prevention and possibly treatment. But the management and resolution of such an immensely complex system is difficult and may require a multidisciplinary approach including physics, biology, biochemistry and medical science...
March 2018: Medical Hypotheses
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