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https://www.readbyqxmd.com/read/27910985/uvb-radiation-vitamin-d-and-multiple-sclerosis
#1
H F DeLuca, L Plum
Acheson et al. (1960) observed an inverse relationship between sunlight exposure and the incidence of Multiple Sclerosis (MS). This led to the suggestion that increased levels of vitamin D caused by sunlight in some way suppresses MS. Further, super physiological doses of the metabolically active metabolite of vitamin D, i.e. 1α,25 dihydroxy vitamin D suppresses the animal model of MS i.e. experimental autoimmune encephalomyelitis (EAE). However, this response was accompanied by hypercalcemia. Hypercalcemia itself can suppress EAE...
December 2, 2016: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/27907873/excellent-storage-stability-and-sensitive-detection-of-neurotoxin-quinolinic-acid
#2
Ranjana Singh, Sunayana Kashyap, Suveen Kumar, Shiju Abraham, Tejendra K Gupta, Arvind M Kayastha, Bansi D Malhotra, Preeti Suman Saxena, Anchal Srivastava, Ranjan K Singh
Quinolinic acid (QA) is a metabolite of tryptophan degradation obtained through kynurenine pathway, produced naturally in the mammalian brain as well as in the human cerebrospinal fluid. The presence of QA ~10-40µM is a clear indicator of many neurological disorders as well as deficiency of vitamin B6 in human being. In the present work; rapid, sensitive and cost-effective bio-electrodes were prepared to detect the trace amount of endogenous neurotoxin (QA). Cyclic voltammetry (CV) and differential pulse voltammetry (DPV) studies were carried out to measure the electrochemical response of the fabricated bio-electrodes as a function of QA concentrations...
November 23, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27904620/the-relationship-between-vitamin-d-clinical-outcomes-and-mortality-rate-in-icu-patients-a-prospective-observational-study
#3
Nooshin Vosoughi, Parviz Kashefi, Behnood Abbasi, Awat Feizi, Gholamreza Askari, Leila Azadbakht
BACKGROUND: According to the high prevalence of Vitamin D deficiency, a few studies have been conducted to clarify the relationship between 25-hydroxyvitamin D (25(OH)D) and clinical outcomes in critically ill patients. The objective of this study was to determine this probable association. MATERIALS AND METHODS: Serum 25(OH)D, C-reactive protein, malnutrition measurements, and Intensive Care Unit (ICU)-acquired infection from 185 patients in ICU were assessed in the first 24 h of admission and they were followed for the other outcomes...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27904508/the-effects-of-vitamin-d-on-severity-of-coronary-artery-atherosclerosis-and-lipid-profile-of-cardiac-patients
#4
Ewelina A Dziedzic, Sebastian Przychodzeń, Marek Dąbrowski
INTRODUCTION: A deficiency of 25-hydroxyvitamin D (25(OH)D) (the standard biomarker for vitamin D status) can have multiple impacts on the cardiovascular system. The aim of the study was to assess of the influence of 25(OH)D on severity of coronary atherosclerosis and lipid profile. MATERIAL AND METHODS: The study involved prospectively 637 patients subject to coronary catheterization. The stage of coronary atherosclerosis was assessed using the Coronary Artery Surgery Study score (CASSS)...
December 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/27903815/neonatal-vitamin-d-status-and-risk-of-multiple-sclerosis-a-population-based-case-control-study
#5
Nete Munk Nielsen, Kassandra L Munger, Nils Koch-Henriksen, David M Hougaard, Melinda Magyari, Kristian T Jørgensen, Marika Lundqvist, Jacob Simonsen, Tine Jess, Arieh Cohen, Egon Stenager, Alberto Ascherio
OBJECTIVE: As previous research has suggested that exposure to vitamin D insufficiency in utero may have relevance for the risk of multiple sclerosis (MS), we aimed to examine the direct association between level of neonatal vitamin D and risk of MS. METHODS: We carried out a matched case-control study. Dried blood spots samples (DBSS) belonging to 521 patients with MS were identified in the Danish Newborn Screening Biobank. For every patient with MS, 1-2 controls with the same sex and birth date were retrieved from the Biobank (n = 972)...
November 30, 2016: Neurology
https://www.readbyqxmd.com/read/27903519/dairy-intake-and-fecundability-in-2-preconception-cohort-studies
#6
Lauren A Wise, Amelia K Wesselink, Ellen M Mikkelsen, Heidi Cueto, Kristen A Hahn, Kenneth J Rothman, Katherine L Tucker, Henrik Toft Sørensen, Elizabeth E Hatch
BACKGROUND: Animal studies have shown that a high intake of galactose, a breakdown product of lactose, increases ovarian toxicity. Few epidemiologic studies, to our knowledge, have examined the association between dairy intake and fertility, and they have had conflicting findings. OBJECTIVE: We prospectively evaluated dairy intake in relation to fecundability among women who were planning for pregnancy. DESIGN: Data were derived from preconception cohort studies in Denmark (Snart Foraeldre) and North America [PRESTO (Pregnancy Study Online)] in which women completed a validated food-frequency questionnaire 10 d after enrollment...
November 30, 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27901247/anabolic-steroids-for-rehabilitation-after-hip-fracture-in-older-people
#7
Vaqas Farooqi, Maayken E L van den Berg, Ian D Cameron, Maria Crotty
BACKGROUND: Hip fracture occurs predominantly in older people, many of whom are frail and undernourished. After hip fracture surgery and rehabilitation, most patients experience a decline in mobility and function. Anabolic steroids, the synthetic derivatives of the male hormone testosterone, have been used in combination with exercise to improve muscle mass and strength in athletes. They may have similar effects in older people who are recovering from hip fracture. OBJECTIVES: To examine the effects (primarily in terms of functional outcome and adverse events) of anabolic steroids after surgical treatment of hip fracture in older people...
September 2016: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/27901035/homocysteine-reducing-b-vitamins-and-ischemic-heart-disease-a-separate-sample-mendelian-randomization-analysis
#8
J V Zhao, C M Schooling
BACKGROUND/OBJECTIVES: Observationally, homocysteine is positively associated with ischemic heart disease (IHD) and unhealthy lipids; folate and vitamin B12, which reduce homocysteine, are associated with lower IHD risk and healthy lipids. Randomized controlled trials have shown no benefits of folate and vitamin B12 for IHD. To clarify the role of these potential targets of intervention in IHD we assessed how genetically determined homocysteine, folate and vitamin-B12-affected IHD and lipids...
November 30, 2016: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27899528/relationship-between-outdoor-temperature-and-cardiovascular-disease-risk-factors-in-older-people
#9
Claudio Sartini, Sarah Je Barry, Peter H Whincup, S Goya Wannamethee, Gordon DO Lowe, Barbara J Jefferis, Lucy Lennon, Paul Welsh, Ian Ford, Naveed Sattar, Richard W Morris
BACKGROUND: Previous studies demonstrated that lower outdoor temperatures increase the levels of established cardiovascular disease risk factors, such as blood pressure and lipids. Whether or not low temperatures increase novel cardiovascular disease risk factors levels is not well studied. The aim was to investigate associations of outdoor temperature with a comprehensive range of established and novel cardiovascular disease risk factors in two large Northern European studies of older adults, in whom cardiovascular disease risk is increased...
November 29, 2016: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/27898998/nutritional-supplementation-for-hip-fracture-aftercare-in-older-people
#10
REVIEW
Alison Avenell, Toby O Smith, James P Curtain, Jenson Cs Mak, Phyo K Myint
BACKGROUND: Older people with hip fractures are often malnourished at the time of fracture, and subsequently have poor food intake. This is an update of a Cochrane review first published in 2000, and previously updated in 2010. OBJECTIVES: To review the effects (benefits and harms) of nutritional interventions in older people recovering from hip fracture. SEARCH METHODS: We searched the Cochrane Bone, Joint and Muscle Trauma Group Specialised Register, CENTRAL, MEDLINE, MEDLINE In-Process & Other Non-Indexed Citations, Embase, CAB Abstracts, CINAHL, trial registers and reference lists...
November 30, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27898857/vitamin-e-plasma-kinetics-in-swine-show-low-bioavailability-and-short-half-life-of-%C3%AE-tocopheryl-acetate
#11
T A T G van Kempen, M H Reijersen, C de Bruijn, S De Smet, J Michiels, M G Traber, C Lauridsen
Vitamin E is important for animal production because of its effects on health and product quality, but the amount and form required remains controversial. Our objective was to quantify the absolute bioavailability of oral -α-tocopheryl acetate (α-TAc) in swine (22 ± 1 kg and 8 wk old, fitted with jugular catheters) adapted to a diet supplemented with 75 mg/kg -α-TAc; 75 mg/kg was chosen because this level represents the nonweighted average inclusion level in piglet diets across Western key swine-producing countries...
October 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27897610/effect-of-calcitriol-supplementation-on-blood-pressure-in-older-adults
#12
Jaime Alberto Bricio-Barrios, Alín Jael Palacios-Fonseca, Mario Del Toro-Equihua, Carmen Alicia Sanchez-Ramirez
Recent studies suggest that vitamin D plays an important role in the control of blood pressure. Unfortunately, because older adults are more likely to have low 25-hydroxyvitamin-D [25(OH)D] levels, this study investigated whether calcitriol supplementation reduces blood pressure in older adults with hypertension. The design was a double-blind placebo-controlled randomized clinical trial with 36 randomly assigned subjects (71.7 ± 10 years). Blood pressure and serum levels of 25(OH)D before and after calcitriol intervention (1,000 IU daily for 6 weeks; n = 22) or placebo (n = 23) for 6 weeks were analyzed...
October 2016: Journal of Nutrition in Gerontology and Geriatrics
https://www.readbyqxmd.com/read/27897409/association-of-serum-vitamin-d-with-osteosarcopenic-obesity-korea-national-health-and-nutrition-examination-survey-2008-2010
#13
Jinhee Kim, Yunhwan Lee, Seunghee Kye, Yoon-Sok Chung, Okhee Lee
BACKGROUND: Serum vitamin D levels have been reported to be associated with individual components of body composition. However, the relationship between serum vitamin D and combined indices of adverse body composition is largely unknown. This cross-sectional study examined the association between serum vitamin D and osteosarcopenic obesity in a nationally representative sample of middle-aged and older adults. METHODS: We analysed the Korea National Health and Nutrition Examination Surveys (IV and V) conducted in 2008-2010, consisting of 5908 (2485 men, 3423 women) aged ≥ 50 years...
October 5, 2016: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/27896937/effect-of-tailored-dietary-guidance-for-pregnant-women-on-nutritional-status-a-double-cohort-study
#14
Megumi Haruna, Mie Shiraishi, Masayo Matsuzaki, Yuko Yatsuki, SeonAe Yeo
This double cohort study aimed to evaluate the effect of tailored dietary guidance for pregnant women on dietary intake, nutritional status, and infant birth weight. Healthy pregnant women were recruited at an antenatal clinic during two phases over 2 years. The historical controls were analyzed a year prior to the intervention group. In both groups, data were collected at 19-26 gestational weeks (baseline) and at 34-37 gestational weeks (outcome measurement). The intervention included the following: (a) assessments of maternal dietary nutritional intake using the brief self-administered diet history questionnaire, (b) individual feedback based on the assessments of maternal nutritional status, (c) tailored guidance for a healthy diet, (d) original cooking recipes, and (e) goal sharing...
November 29, 2016: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/27895928/assessing-the-population-impact-of-low-rates-of-vitamin-d-supplementation-on-type-1-diabetes-using-a-new-statistical-method
#15
Christos S Zipitis, Zulf M Mughal, Peter E Clayton
Vitamin D supplementation for all children <5 is recommended by the UK Department of Health for its skeletal effects. Vitamin D is also linked with a number of extra-skeletal effects; one of them being protection against type 1 diabetes. With a rapid increase in the incidence of type 1 diabetes and the associated costs, measures of curtailing the rapid increase of type 1 diabetes are needed. In this review, we look at type 1 diabetes using a statistical method (PIN-ER-t) and published data in an attempt to quantify the impact on the population of babies born in 2012 of increasing vitamin D supplementation rates...
November 2016: JRSM Open
https://www.readbyqxmd.com/read/27895486/factors-associated-with-vitamin-d-status-of-low-income-hospitalized-psychiatric-patients-results-of-a-retrospective-study
#16
Alessandra N Bazzano, Lisa Littrell, Stephen Lambert, Cody Roi
BACKGROUND: Recent evidence has indicated a potential role of vitamin D3 in a range of neuropsychiatric outcomes, as well as on cognitive function, but conflicting data have left that role uncertain. Understanding potential associations of vitamin D status with psychiatric illness will allow clinicians to better assess therapeutic options. Few studies have examined vitamin D status among a racially diverse group of psychiatric patients who have been hospitalized, and none has done so in the southern US where socioeconomic inequality is high...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27895321/is-nasal-polyposis-related-to-levels-of-serum-vitamin-d-and-vitamin-d-receptor-gene-expression
#17
Omer Erdag, Mahfuz Turan, Rıfkı Ucler, Mehmet Berkoz, Mehmet Fatih Garca, Nazım Bozan, Ahmet Faruk Kıroglu, Hakan Cankaya
BACKGROUND Nasal polyposis (NP) is the most frequent cause of nasal masses. Despite considerable research on the subject, its etiology has not been fully elucidated, and effective treatment methods have not been developed. Some etiological factors causing low or high expression of genes in genetically predisposed individuals may play a role in the pathogenesis of the disease. The purpose of this study was to assess the relation between levels of vitamin D receptor (VDR) gene expression and serum vitamin D with NP...
November 29, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27893995/combined-effects-of-cadmium-temperature-and-hypoxia-reoxygenation-on-mitochondrial-function-in-rainbow-trout-oncorhynchus-mykiss
#18
John O Onukwufor, Don Stevens, Collins Kamunde
Although aquatic organisms face multiple environmental stressors that may interact to alter adverse outcomes, our knowledge of stressor-stressor interaction on cellular function is limited. We investigated the combined effects of cadmium (Cd), hypoxia-reoxygenation (H-R) and temperature on mitochondrial function. Liver mitochondria from juvenile rainbow trout were exposed to Cd (0-20μM) and H-R (0 and 5min) at 5, 13 and 25°C followed by measurements of mitochondrial Cd load, volume, complex І active (A)↔deactive (D) transition, membrane potential, ROS release and ultrastructural changes...
November 18, 2016: Aquatic Toxicology
https://www.readbyqxmd.com/read/27893751/25-hydroxy-and-1%C3%AE-25-dihydroxycholecalciferol-have-greater-potencies-than-25-hydroxy-and-1%C3%AE-25-dihydroxyergocalciferol-in-modulating-cultured-human-and-mouse-osteoblast-activities
#19
Allahdad Zarei, Philippa A Hulley, Afsie Sabokbar, M Kassim Javaid, Alireza Morovat
Despite differences in the phamacokinetics of 25-hydroxycholecalciferol (25(OH)D3) and 25-hydroxyergocalciferol (25(OH)D2) in man, the effects of these and their 1α-hydroxylated forms (1,25(OH)2D3 and 1,25(OH)2D2) on cellular activity of vitamin D-responsive cells have hardly been compared. We studied differences in the effects of these metabolites on cell number, gene transcription, protein expression and mineralisation of cultured human bone marrow-derived stromal cells (hBMSC) and rapidly mineralising mouse 2T3 osteoblasts...
2016: PloS One
https://www.readbyqxmd.com/read/27891186/relationship-between-vitamin-d-status-glycemic-control-and-cardiovascular-risk-factors-in-brazilians-with-type-2-diabetes-mellitus
#20
Maria Creusa Rolim, Bárbara Mendes Santos, Gildasio Conceição, Paulo Novis Rocha
OBJECTIVES: Determine the prevalence and identify predictors of hypovitaminosis D in patients with type 2 diabetes mellitus (T2DM); 2) correlate vitamin D levels with variables indicative of glycemic control and cardiovascular risk. RESEARCH DESIGN AND METHODS: We conducted a cross-sectional study with consecutive patients treated at a University Hospital's Endocrinology outpatient clinic located at 12°58'S latitude, between October 2012 and November 2013. Hypovitaminosis D was defined as 25-hydroxyvitamin D < 30 ng/mL (chemiluminescence)...
2016: Diabetology & Metabolic Syndrome
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