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https://www.readbyqxmd.com/read/28822308/the-acute-effects-of-ultraviolet-radiation-on-the-blood-transcriptome-are-independent-of-plasma-25ohd3
#1
Mariona Bustamante, Carles Hernandez-Ferrer, Yaris Sarria, Graham I Harrison, Lara Nonell, Wenjing Kang, Marc R Friedländer, Xavier Estivill, Juan R González, Mark Nieuwenhuijsen, Antony R Young
The molecular basis of many health outcomes attributed to solar ultraviolet radiation (UVR) is unknown. We tested the hypothesis that they may originate from transcriptional changes in blood cells. This was determined by assessing the effect of fluorescent solar simulated radiation (FSSR) on the transcriptional profile of peripheral blood pre- and 6h, 24h and 48h post-exposure in nine healthy volunteers. Expression of 20 genes was down-regulated and one was up-regulated at 6h after FSSR. All recovered to baseline expression at 24h or 48h...
August 16, 2017: Environmental Research
https://www.readbyqxmd.com/read/28822064/evolution-of-29-anthropometric-nutritional-and-cardiometabolic-parameters-among-morbidly-obese-adolescents-2-years-post-sleeve-gastrectomy
#2
Wahiba Elhag, Walid El Ansari, Sama Abdulrazzaq, Ali Abdullah, Mohamed Elsherif, Israa Elgenaied
BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) is a popular treatment for adolescent morbid obesity. Research on LSG outcomes among adolescents assessed a narrow range of anthropometric, nutritional, or cardiometabolic parameters, leading to an incomplete picture of these changes. We examined a wide variety of anthropometric, nutritional, and cardiometabolic parameters among adolescents before and after LSG. METHODS: We retrospectively reviewed medical charts of all obese adolescents who underwent LSG at Hamad Medical Corporation, Qatar, between January 2011 and June 2015 (N = 102)...
August 18, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28815553/osteoporosis-in-erythropoietic-protoporphyria-patients
#3
M Biewenga, R H S Matawlie, E C H Friesema, H Koole-Lesuis, M Langeveld, J H P Wilson, J G Langendonk
BACKGROUND: Erythropoietic protoporphyria is a rare metabolic disease with painful photosensitivity due to protoporphyrin IX accumulation, resulting in lifelong light avoidance behaviour. OBJECTIVES: The aim of this study was to evaluate bone mineral density and known osteoporosis risk factors in erythropoietic protoporphyria patients. METHODS: In this cross-sectional study all erythropoietic protoporphyria patients attending the Erasmus MC outpatient clinic that had undergone bone mineral density measurements were included...
August 17, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28814531/patients-with-nonalcoholic-fatty-liver-disease-have-a-low-response-rate-to-vitamin-d-supplementation
#4
Jaividhya Dasarathy, Rony Varghese, Abram Feldman, Amer Khiyami, Arthur J McCullough, Srinivasan Dasarathy
Background: Hypovitaminosis D is associated with an increased severity of nonalcoholic fatty liver disease (NAFLD), but reports on the response to cholecalciferol (vitamin D3) supplementation are conflicting.Objective: The objective of this study was to determine if standard vitamin D3 supplementation is effective in NAFLD with hypovitaminosis D.Methods: Sixty-five well-characterized adults [age (mean ± SD): 51.6 ± 12.3 y] with biopsy-proven NAFLD were screened. Forty-two patients (the ratio of men to women was 13:29) had hypovitaminosis D (plasma 25-hydroxyvitamin D [25(OH)D] <30 ng/mL)...
August 16, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28813022/impact-of-orientation-on-the-vitamin-d-weighted-exposure-of-a-human-in-an-urban-environment
#5
Michael Schrempf, Nadine Thuns, Kezia Lange, Gunther Seckmeyer
The vitamin D₃-weighted UV exposure of a human with vertical posture was calculated for urban locations to investigate the impact of orientation and obstructions on the exposure. Human exposure was calculated by using the 3D geometry of a human and integrating the radiance, i.e., the radiant energy from the direct solar beam and the diffuse sky radiation from different incident and azimuth angles. Obstructions of the sky are derived from hemispherical images, which are recorded by a digital camera with a fisheye lens...
August 16, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28812446/higher-dietary-intake-of-vitamin-d-may-influence-total-cholesterol-and-carbohydrate-profile-independent-of-body-composition-in-men-with-chronic-spinal-cord-injury
#6
Christopher Beal, Ashraf Gorgey, Pamela Moore, Nathan Wong, Robert A Adler, David Gater
STUDY DESIGN: A case-control design. OBJECTIVES: To determine the effects of dietary vitamin D intake on insulin sensitivity (Si), glucose effectiveness (Sg), and lipid profile in individuals with spinal cord injury (SCI). METHODS: 20 male, paraplegic (T3-L1) with chronic (> one year) motor complete SCI (AIS A or B) were recruited. Three-day dietary records were analyzed for dietary vitamin D (calciferol), and participants were assigned to one of two groups, a high vitamin D intake group and a low vitamin D intake group based on the mid-point of vitamin D frequency distribution...
August 16, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28811787/association-between-vitamin-d-deficiency-and-breast-cancer
#7
Noureen Shaukat, Farhat Jaleel, Foad Ali Moosa, Naeem Akhter Qureshi
OBJECTIVE: To determine the association between vitamin D deficiency and breast cancer. METHODS: This case control study included 94 female patients aged 20-75 years of any marital status and parity. Newly diagnosed 42 breast cancer patients who presented to surgical OPD of Dow University Hospital from Jan 2016 to June 2016 were included into the study as "cases" after informed consent. Age-matched 52 females who presented to OPD for complain other than breast pathology were included as the "control group"...
May 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28809744/effect-of-vitamin-d-serum-levels-and-gc-gene-polymorphisms-in-liver-fibrosis-due-to-chronic-hepatitis-c
#8
Laura A Azevedo, Ursula Matte, Themis R Silveira, Jacqueline W Bonfanti, Juliana P Bruch, Mário R Álvares-da-Silva
INTRODUCTION AND AIM: Vitamin D has been associated with chronic liver diseases and low vitamin levels may contribute to progression of chronic hepatitis C. The aim of this study was to evaluate the influence of vitamin D serum levels and GC gene polymorphisms in the severity of liver fibrosis in patients with chronic hepatitis C genotype 1. MATERIAL AND METHODS: Cross-sectional study that enrolled 132 adult patients with chronic hepatitis C genotype 1 attended at the outpatient Clinic of Gastroenterology Division at Hospital de Clínicas de Porto Alegre...
August 8, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28808858/vitamin-d-and-heart-failure
#9
REVIEW
D Marshall Brinkley, Omair M Ali, Sandip K Zalawadiya, Thomas J Wang
PURPOSE: Vitamin D is principally known for its role in calcium homeostasis, but preclinical studies implicate multiple pathways through which vitamin D may affect cardiovascular function and influence risk for heart failure. Many adults with cardiovascular disease have low vitamin D status, making it a potential therapeutic target. We review the rationale and potential role of vitamin D supplementation in the prevention and treatment of chronic heart failure. RECENT FINDINGS: Substantial observational evidence has associated low vitamin D status with the risk of heart failure, ventricular remodeling, and clinical outcomes in heart failure, including mortality...
August 14, 2017: Current Heart Failure Reports
https://www.readbyqxmd.com/read/28808057/a-kidney-specific-genetic-control-module-in-mice-governs-endocrine-regulation-of-the-cytochrome-p450-gene-cyp27b1-essential-for-vitamin-d3-activation
#10
Mark B Meyer, Nancy A Benkusky, Martin Kaufmann, Seong Min Lee, Melda Onal, Glenville Jones, J Wesley Pike
The vitamin D endocrine system regulates mineral homeostasis through its activities in the intestine, kidney, and bone. Terminal activation of vitamin D3 to its hormonal form, 1,25(OH)2D3, occurs in the kidney via the cytochrome P450 enzyme CYP27B1. Despite its importance in vitamin D metabolism, the molecular mechanisms underlying the regulation of the gene for this enzyme, Cyp27b1, are unknown. Here, we identified a kidney-specific control module governed by a renal cell-specific chromatin structure located distal to Cyp27b1 that mediates unique basal and parathyroid hormone (PTH)-, fibroblast growth factor 23 (FGF23)-, and 1,25(OH)2D3-mediated regulation of Cyp27b1 expression...
August 14, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28807865/novel-compound-heterozygous-mutations-identified-by-whole-exome-sequencing-in-a-japanese-patient-with-geroderma-osteodysplastica
#11
Ryojun Takeda, Masaki Takagi, Hiroyuki Shinohara, Hiroshi Futagawa, Satoshi Narumi, Tomonobu Hasegawa, Gen Nishimura, Hiroshi Yoshihashi
Geroderma osteodysplastica (GO) is a subtype of cutis laxa syndrome characterized by congenital wrinkly skin, a prematurely aged face, extremely short stature, and osteoporosis leading to recurrent fractures. GO exhibits an autosomal recessive inheritance pattern and is caused by loss-of-function mutations in GORAB, which encodes a protein important for Golgi-related transport. Using whole exome sequencing, we identified novel compound heterozygous nonsense mutations in the GORAB in a GO patient. The patient was a 14-year-old Japanese boy...
August 11, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/28806178/vitamin-d-and-osteosarcopenia-an-update-from-epidemiological-studies
#12
Olivier Bruyère, Etienne Cavalier, Jean-Yves Reginster
PURPOSE OF REVIEW: The review summarizes recent epidemiological studies that examined the relationship between osteoporosis and sarcopenia to assess the impact of vitamin D status or supplementation on health outcomes related to these two medical conditions. RECENT FINDINGS: Osteoporosis and sarcopenia are major public health problems, but whether these two diseases should be considered alone or combined into a single condition is not clear. No consensual definition of osteosarcopenia is largely accepted...
August 12, 2017: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/28806113/-hungarian-diet-and-nutritional-status-survey-the-otap2014-study-v-vitamin-intake-of-the-hungarian-population
#13
Erzsébet Schreiberné Molnár, Zsuzsanna Nagy-Lőrincz, Barbara Nagy, Márta Bakacs, Orsolya Kis, Eszter Sarkadi Nagy, Éva Martos
INTRODUCTION AND AIM: The Hungarian Diet and Nutritional Status Survey was implemented on a sub-sample of the European Health Interview Survey. In this paper, the authors present the data on the vitamin intake of the Hungarian population. METHOD: The survey represents the vitamin intake of the Hungarian non-institutionalised adult population of 18 years and older. There are significant differences between men's and women's vitamin intake. RESULTS: The intake of all water-soluble vitamins except for vitamin C is higher in men than in women, and the difference between the genders regarding the intake of vitamin E and D is significant...
August 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28806048/electrolytes-calcium-disorders
#14
Craig Barstow
A normal serum calcium level is 8 to 10 mg/dL. The diagnosis of hypercalcemia (ie, levels 10.5 mg/dL or greater) should be confirmed with an albumin-adjusted or ionized calcium level. The two most common causes of hypercalcemia are hyperparathyroidism and malignancy. Drugs, notably lithium and thiazide diuretics, also can cause hypercalcemia. Patients with severe or symptomatic hypercalcemia should be treated initially with hydration to decrease calcium levels. The evaluation should include a parathyroid hormone (PTH) level...
August 2017: FP Essentials
https://www.readbyqxmd.com/read/28805887/characterizing-ammonia-emissions-from-horses-fed-different-crude-protein-concentrations
#15
J Weir, H Li, L K Warren, E Macon, C Wickens
Evaluating impact of animal agriculture on air quality has been the focus of recent research. Ammonia (NH) volatilization occurs when undigested protein in feces and urea in urine is broken down by bacteria and enzymes. Information regarding NH emission from equine facilities is limited, and effects of CP intake on NH emissions have not been investigated. Nine mature geldings were used in a 3 × 3 replicated Latin square design study to determine effects of dietary CP on potential NH losses from feces and urine...
August 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28803880/vitamin-d-and-symptoms-of-depression-in-overweight-or-obese-adults-a-cross-sectional-study-and-randomized-placebo-controlled-trial
#16
Aya Mousa, Negar Naderpoor, Maximilian P J de Courten, Barbora de Courten
Recent evidence suggests that vitamin D deficiency may contribute to increased risk of depression. However, previous studies are limited by variability in participant characteristics including vitamin D deficiency status and presence of existing diseases, use of low doses of vitamin D supplementation for short durations, and use of co-interventions or psychotropic drugs. We examined whether 25-hydroxyvitamin D (25(OH)D) concentrations were associated with symptoms of depression, as well as whether vitamin D supplementation reduced symptoms of depression in overweight or obese and vitamin D-deficient, but otherwise healthy adults...
August 10, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28803689/sun-exposure-influences-the-prognostic-power-of-components-of-mineral-metabolism-in-patients-with-coronary-artery-disease
#17
A Aceña, J A Franco-Peláez, C Gutierrez-Landaluce, A M Pello, C Cristóbal, N Tarín, A Huelmos, R Carda, M L Martín-Mariscal, J Alonso, E González-Parra, M L González-Casaus, Ó Lorenzo, L López Bescos, J Egido, J Tuñón
BACKGROUND AND AIM: Calcidiol (vitamin D metabolite) plasma levels vary with sun exposure (SE). However, it is not known if SE influences its prognostic ability. We have studied the effect of SE on plasma levels of the components of mineral metabolism (calcidiol, fibroblast growth factor-23 [FGF-23], parathormone [PTH], and phosphate [P]) and on their prognostic value in patients with coronary artery disease (CAD). METHODS AND RESULTS: We studied prospectively 704 patients with stable CAD...
June 15, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28803664/should-patients-take-vitamin-d-before-mandibular-operations
#18
N Syed, G A Chiu, P Korczak
Vitamin D deficiency is endemic in the United Kingdom (UK), particularly in high-risk groups. We report the outcomes of patients with low concentrations of the vitamin who had complications after reduction of mandibular fractures or osteotomy, and those who were screened preoperatively. A deficiency can be diagnosed with a simple and inexpensive blood test, and in the UK the cost of a vitamin D tablet is about £0.04/tablet/day. Patients at risk of a deficiency should be screened before mandibular operations, and those listed for orthognathic surgery or replacement of the temporomandibular joint should be asked to take a supplement before operation...
August 10, 2017: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/28803336/transgenic-mice-overexpressing-vitamin-d-receptor-vdr-show-anti-inflammatory-effects-in-lung-tissues
#19
Masaki Ishii, Yasuhiro Yamaguchi, Kyoko Isumi, Sumito Ogawa, Masahiro Akishita
Vitamin D insufficiency is increasingly recognized as a prevalent problem worldwide, especially in patients with a chronic lung disease. Chronic obstructive pulmonary disease (COPD) is a type of chronic inflammatory lung disease. Previous clinical studies have shown that COPD leads to low vitamin D levels, which further increase the severity of COPD. Vitamin D homeostasis represents one of the most important factors that potentially determine the severity of COPD. Nonetheless, the mechanisms underlying the anti-inflammatory effects of vitamin D receptor (VDR) in lung tissues are still unclear...
August 12, 2017: Inflammation
https://www.readbyqxmd.com/read/28802294/serum-25-hydroxyvitamin-d-and-elderly-skeletal-muscle-mass-and-function-in-urban-north-china
#20
Liping Meng, Qingqing Man, Linhong Yuan, Lingxia Shen, Weimin Li, Guiyuan Guo, Lixiang Li, Shanshan Jia, Yixiong Gao, Pengkun Song, Jian Zhang
BACKGROUND AND OBJECTIVES: To investigate the association of serum 25-hydroxyvitamin D (25(OH)D) with skeletal muscle mass (SMM) and function among the elderly in an urban area in northern China. METHODS AND STUDY DESIGN: A total of 912 participants (316 men, 596 women) aged more than 60 years from 4 communities in Beijing were enrolled. Serum concentrations of 25(OH)D were measured through radioimmunoassay. SMM was assessed through bioelectrical impendence analysis, whereas skeletal muscle function was assessed through grip strength and 4-m regular gait speed measurements...
2017: Asia Pacific Journal of Clinical Nutrition
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