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https://www.readbyqxmd.com/read/29233500/tumor-budding-is-a-prognostic-factor-linked-to-epithelial-mesenchymal-transition-in-pancreatic-ductal-adenocarcinoma-study-report-and-literature-review
#1
Ezzeddine Chouat, Alia Zehani, Ines Chelly, Manel Njima, Houcine Maghrebi, Mohammed Amine Bani, Leila Njim, Abdelfatteh Zakhama, Slim Haouet, Nidhameddine Kchir
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) has a devastatingly poor prognosis. Surgical resection is undertaken in only 20% of patients. Most of well-known prognostic factors reflect tumor stage more than its biology. So it is important to identify new biological indicators related to survival in order to develop new therapies. OBJECTIVE: To determine the relation between tumor budding and Epithelial Mesenchymal Transition (EMT) and to evaluate their impact on survival for patients after resection of PDAC...
November 21, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29231050/follow-up-interval-for-probably-benign-breast-lesions-on-screening-ultrasound-in-women-at-average-risk-for-breast-cancer-with-dense-breasts
#2
Hee Jung Moon, Min Jung Kim, Jung Hyun Yoon, Eun-Kyung Kim
Background Women at high risk for breast cancer and women at average risk have different pretest probabilities. Probably benign lesions on screening ultrasound (US) should be assessed and managed differently for these two risk groups. Purpose To evaluate the effectiveness of short-term follow-up for probably benign lesions on screening US in women at average risk for breast cancer with dense breasts. Material and Methods A total of 445 women at average risk for breast cancer with probably benign lesions on screening US, dense breasts, and negative or benign mammography results were included...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/29230662/relationship-of-histologic-grade-and-histologic-subtype-with-oncotype-dx-recurrence-score-retrospective-review-of-863-breast-cancer-oncotype-dx-results
#3
Kamaljeet Singh, Xin He, Elizabeth T Kalife, Shahrzad Ehdaivand, Yihong Wang, C James Sung
PURPOSE: Oncotype Dx (ODx) is a multigene assay that is prognostic and predictive in estrogen receptor (ER) positive early breast cancer. ODx recurrence score (RS) is reported to be histologic grade dependent. Relationship of RS with breast cancer histologic subtypes is unknown. This study was designed to assess the relationship of histologic subtype with RS. Histologic grade dependence of RS was also investigated. METHODS: Results of consecutive ODx tests (1/2007-7/2016) from two institutions were reviewed...
December 11, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29230302/letrozole-induced-hepatitis-with-autoimmune-features-a-rare-adverse-drug-reaction-with-review-of-the-relevant-literature
#4
Bharatsinh Gharia, Karan Seegobin, Satish Maharaj, Noor Marji, Amie Deutch, Lara Zuberi
While aromatase inhibitors (AIs) have been known to cause minor elevations in liver enzymes, severe hepatotoxicity is rare. To the best of our knowledge, this is the first reported case of Letrozole-induced hepatitis with autoimmune features. A 70-year-old female with estrogen positive, invasive ductal carcinoma of the breast, presented with jaundice 3 months after starting letrozole. Hepatic transaminases were markedly elevated and her ANA and anti-smooth muscle antibody was positive. Liver biopsy featured drug-induced hepatitis...
November 2017: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/29230119/a-potential-additional-variable-to-consider-in-the-surgical-treatment-of-ductal-carcinoma-in-situ
#5
Katherine Chaisson, Amy Rivere, Ralph Corsetti, Tova Weiss, George M Fuhrman
Background: HER2/neu is a potentially interesting variable that has been demonstrated to have a profound impact on the management of invasive breast carcinoma, and we performed this study to evaluate the differences between HER2-positive and HER2-negative ductal carcinoma in situ. The impetus for this study was our poor recruitment to the National Surgical Adjuvant Breast and Bowel Project Protocol B-43 trial that was designed to evaluate the potential role of trastuzumab in breast conservation therapy for patients with HER2-positive ductal carcinoma in situ...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/29229290/simple-detection-of-telomere-fusions-in-pancreatic-cancer-intraductal-papillary-mucinous-neoplasm-and-pancreatic-cyst-fluid
#6
Tatsuo Hata, Marco Dal Molin, Anne McGregor-Das, Tae Jun Song, Christopher Wolfgang, James R Eshleman, Ralph H Hruban, Michael Goggins
Telomere end-to-end fusions are an important source of chromosomal instability that arise in cells with critically shortened telomeres. We developed a nested real-time quantitative PCR method for telomere fusion detection in pancreatic ductal adenocarcinomas, intraductal papillary mucinous neoplasms (IPMNs), and IPMN cyst fluids. Ninety-one pancreatic cancer cell lines and xenograft samples, 93 IPMNs, and 93 surgically aspirated IPMN cyst fluid samples were analyzed. The association between telomere shortening, telomerase activity, and telomere fusion detection was evaluated...
December 6, 2017: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/29228910/the-prognosis-of-invasive-micropapillary-carcinoma-compared-with-invasive-ductal-carcinoma-in-the-breast-a-meta-analysis
#7
Yun Wu, Ning Zhang, Qifeng Yang
BACKGROUND: Invasive micropapillary carcinoma (IMPC) of the breast is a rare variant of invasive ductal carcinoma (IDC). The prognosis of IMPC compared with that of IDC remains controversial; we conducted a meta-analysis to evaluate the prognostic difference between IMPC and IDC. METHODS: We searched the PubMed, Cochrane Library, and EMBASE databases for relevant studies comparing overall survival (OS), disease-specific survival (DSS), relapse-free survival (RFS), local-regional recurrence-free survival (LRRFS) or distant metastasis-free survival (DMFS) rates between IMPC and IDC...
December 11, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29224275/-clinicopathologic-study-of-infiltrating-epitheliosis-of-the-breast
#8
X L Xu, X Y Tu, R H Shui, Y F Cheng, B H Yu, W T Yang
Objective: To evaluate the morphological and immunohistochemical features of infiltrating epitheliosis and its differential diagnosis. Methods: Nine consultation and routine cases of infiltrating epitheliosis diagnosed from January 2015 to December 2016 in Fudan University Shanghai Cancer Center were collected. All tissues were formalin-fixed paraffin-embedded and routinely HE stained. The HE slides were reviewed. Immunohistochemical staining of CKpan, CK7, CK19, CK5/6, CK14, p63, SMMHC, Calponin, ER, PR, HER2, Ki-67 and S-100 protein was performed using Ventana BenchMark automated immunostainer...
December 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29224225/down-regulation-of-15-pgdh-by-interleukin-1-beta-from-activated-macrophages-leads-to-poor-prognosis-in-pancreatic-cancer
#9
Kota Arima, Yoshihiro Komohara, Luke Bu, Masayo Tsukamoto, Rumi Itoyama, Keisuke Miyake, Tomoyuki Uchihara, Yoko Ogata, Shigeki Nakagawa, Hirohisa Okabe, Katsunori Imai, Daisuke Hashimoto, Akira Chikamoto, Yo-Ichi Yamashita, Hideo Baba, Takatsugu Ishimoto
Chronic inflammation has a crucial role in cancer development and the progression of various tumors, including pancreatic ductal adenocarcinoma (PDAC). The arachidonate cascade is a major inflammatory pathway that produces several metabolites, such as prostaglandin E2 (PGE2 ). The enzyme 15-hydroxyprostaglandin dehydrogenase (15-PGDH) degrades prostaglandin and is frequently decreased in several types of cancer; however, the molecular mechanisms of 15-PGDH suppression are unclear. The current study was conducted to elucidate the molecular mechanisms and clinical significance of 15-PGDH suppression in PDAC...
December 10, 2017: Cancer Science
https://www.readbyqxmd.com/read/29222935/risk-factors-for-positive-resection-margins-of-breast-cancer-tumorectomy-specimen-following-breast-conserving-surgery
#10
Niko Heiss, Valentin Rousson, Assia Ifticene-Treboux, Hans-Anton Lehr, Jean-François Delaloye
Background The aim of the study was to identify risk factors for positive surgical margins in breast-conserving surgery for breast cancer and to evaluate the influence of surgical experience in obtaining complete resection. Methods All lumpectomies for invasive breast carcinoma and ductal carcinoma in situ (DCIS) between April 2008 and March 2010 were selected from the database of a single institution. Re-excision rates for positive margins as well as patient and histopathologic tumor characteristics were analyzed...
December 9, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29221896/correlative-imaging-reveals-physiochemical-heterogeneity-of-microcalcifications-in-human-breast-carcinomas
#11
Jennie A M R Kunitake, Siyoung Choi, Kayla X Nguyen, Meredith M Lee, Frank He, Daniel Sudilovsky, Patrick G Morris, Maxine S Jochelson, Clifford A Hudis, David A Muller, Peter Fratzl, Claudia Fischbach, Admir Masic, Lara A Estroff
Microcalcifications (MCs) are routinely used to detect breast cancer in mammography. Little is known, however, about their materials properties and associated organic matrix, or their correlation to breast cancer prognosis. We combine histopathology, Raman microscopy, and electron microscopy to image MCs within snap-frozen human breast tissue and generate micron-scale resolution correlative maps of crystalline phase, trace metals, particle morphology, and organic matrix chemical signatures within high grade ductal carcinoma in situ (DCIS) and invasive cancer...
December 5, 2017: Journal of Structural Biology
https://www.readbyqxmd.com/read/29221789/pretherapy-neutrophil-to-lymphocyte-ratio-and-platelet-to-lymphocyte-ratio-do-not-predict-survival-in-resectable-pancreatic-cancer
#12
Akhil Chawla, Tiffany L Huang, Andrew M Ibrahim, Jeffrey M Hardacre, Christopher Siegel, John B Ammori
BACKGROUND: Pretherapy serum neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) have both been identified as prognostic in pancreatic ductal adenocarcinoma (PDAC). The aim of this study was to identify the prognostic implication of pretherapy NLR and PLR in patients with resectable PDAC. METHODS: Data were collected retrospectively on patients operated at our institution between 2004 and 2014. A Cox proportional hazards model was used to investigate the relationship between clinical and pathological parameters, NLR and PLR to overall survival (OS)...
December 5, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29221719/integration-of-different-criteria-for-borderline-resectable-pancreatic-cancer-using-classification-tree-analysis-the-use-of-radiological-tumour-vascular-interface-in-correlation-with-surgical-and-pathological-outcomes
#13
J A Hwang, K M Jang, S H Kim, T W Kang, K D Song, D I Cha, S Ahn
AIM: To integrate various criteria for borderline resectable pancreatic cancer (BRPC) based on radiological parameters using classification tree analysis. MATERIALS AND METHODS: The institutional review board approved this retrospective study and waived the requirement for informed consent. Two hundred and thirty-five tumour-vein interfaces and 67 tumour-artery interfaces in 245 patients with surgically confirmed pancreatic ductal adenocarcinoma who underwent both preoperative computed tomography (CT) and magnetic resonance imaging (MRI) were assessed by two independent readers...
December 5, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/29221133/endogenous-glutamine-decrease-is-associated-with-pancreatic-cancer-progression
#14
Cecilia Roux, Chiara Riganti, Sammy Ferri Borgogno, Roberta Curto, Claudia Curcio, Valeria Catanzaro, Giuseppe Digilio, Sergio Padovan, Maria Paola Puccinelli, Monica Isabello, Silvio Aime, Paola Cappello, Francesco Novelli
Pancreatic ductal adenocarcinoma (PDAC) is becoming the second leading cause of cancer-related death in the Western world. The mortality is very high, which emphasizes the need to identify biomarkers for early detection. As glutamine metabolism alteration is a feature of PDAC, its in vivo evaluation may provide a useful tool for biomarker identification. Our aim was to identify a handy method to evaluate blood glutamine consumption in mouse models of PDAC. We quantified the in vitro glutamine uptake by Mass Spectrometry (MS) in tumor cell supernatants and showed that it was higher in PDAC compared to non-PDAC tumor and pancreatic control human cells...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29215790/inhibition-of-fucosylation-in-human-invasive-ductal-carcinoma-reduces-e-selectin-ligand-expression-cell-proliferation-and-erk1-2-and-p38-mapk-activation
#15
M A Carrascal, M Silva, J S Ramalho, C Pen, M Martins, C Pascoal, C Amaral, I Serrano, M J Oliveira, R Sackstein, P A Videira
Breast cancer tissue overexpresses fucosylated glycans, such as sialyl-Lewis X/A (sLeX/A ), and α-1,3/4-fucosyltransferases in relation to increased disease progression and metastasis. These glycans in tumor circulating cells mediate binding to vascular E-selectin, initiating tumor extravasation. However, their role(s) in breast carcinogenesis is still unknown. Here, we aimed to define the contribution of the fucosylated structures, including sLeX/A , to cell adhesion, cell signaling and proliferation in invasive ductal carcinomas (IDC), the most frequent type of breast cancer...
December 7, 2017: Molecular Oncology
https://www.readbyqxmd.com/read/29214365/profiling-differential-microrna-expression-between-in-situ-infiltrative-and-lympho-vascular-space-invasive-breast-cancer-a-pilot-study
#16
Patsy S Soon, Pamela J Provan, Edward Kim, Nirmala Pathmanathan, Dinny Graham, Christine L Clarke, Rosemary L Balleine
Ductal carcinoma in situ (DCIS), invasive breast cancer (IBC) and lympho-vascular invasion (LVI) represent distinct stages in breast cancer progression with different clinical implications. Altered microRNA (miRNA) expression may play a role in mediating the progression of DCIS to IBC and LVI. The aim of this pilot study was to investigate whether differential miRNA expression could play a role in breast cancer progression. Cancer cells from DCIS, IBC and LVI were microdissected from formalin fixed paraffin embedded (FFPE) tissue of five breast cancer samples...
December 6, 2017: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/29214316/association-between-hospital-financial-distress-and-immediate-breast-reconstruction-surgery-after-mastectomy-among-women-with-ductal-carcinoma-in-situ
#17
Catherine A Richards, Andrew G Rundle, Jason D Wright, Dawn L Hershman
Importance: Hospital financial distress (HFD) is a state in which a hospital is at risk of closure because of its financial condition. Hospital financial distress may reduce the services a hospital can offer, particularly unprofitable ones. Few studies have assessed the association of HFD with quality of care. Objective: To examine the association between HFD and receipt of immediate breast reconstruction surgery after mastectomy among women diagnosed with ductal carcinoma in situ (DCIS)...
December 6, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/29213099/apparent-diffusion-coefficient-adc-predicts-therapy-response-in-pancreatic-ductal-adenocarcinoma
#18
M Trajkovic-Arsic, I Heid, K Steiger, A Gupta, A Fingerle, C Wörner, N Teichmann, S Sengkwawoh-Lueong, P Wenzel, A J Beer, I Esposito, R Braren, J T Siveke
Recent advances in molecular subtyping of Pancreatic Ductal Adenocarcinoma (PDAC) support individualization of therapeutic strategies in this most aggressive disease. With the emergence of various novel therapeutic strategies and neoadjuvant approaches in this quickly deteriorating disease, robust approaches for fast evaluation of therapy response are urgently needed. To this aim, we designed a preclinical imaging-guided therapy trial where genetically engineered mice harboring endogenous aggressive PDAC were treated with the MEK targeting drug refametinib, which induces rapid and profound tumor regression in this model system...
December 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29212252/c-c-motif-chemokine-receptor-1-ccr1-is-a-target-of-the-egf-akt-mtor-stat3-signaling-axis-in-breast-cancer-cells
#19
Soon Young Shin, Da Hyun Lee, Jishin Lee, Chan Choi, Ji-Young Kim, Jeong-Seok Nam, Yoongho Lim, Young Han Lee
The CC motif chemokine receptor 1 (CCR1) has been implicated in tumor invasion and metastasis in numerous cancers. However, the detailed mechanism of CCR1 upregulation in metastatic tumor cells is poorly understood. The aim of this study was to clarify the regulatory mechanism underlying transcriptional activation of the CCR1 gene in response to epidermal growth factor (EGF) stimulation in breast cancer cells. CCR1 was highly expressed in human breast invasive ductal carcinoma (IDC) compared to adjacent normal tissues...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29209551/synchronous-occurrence-of-primary-breast-carcinoma-and-primary-colon-adenocarcinoma
#20
Gurkan Yetkin, Fevzi Celayir, Ismail Ethem Akgun, Ramazan Ucak
A 65-year-old female patient presented to the emergency clinic with abdominal pain, meteorism, and intermittent rectal bleeding. Colonoscopy was performed, and a hepatic flexure tumor was detected. Histopathological examination of biopsy revealed adenocarcinoma. Thoracoabdominal CT was performed for staging, and a spiculated contour mass was found incidentally on the left breast. Mammography and ultrasonography were performed for the cause of these findings, and suspicious lesions of malignancy were seen in the left breast...
2017: Case Reports in Surgery
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