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invasive ductal

Shohei Kawashiro, Shigeru Yamada, Masahiko Okamoto, Tatsuya Ohno, Takashi Nakano, Makoto Shinoto, Yoshiyuki Shioyama, Kenji Nemoto, Yuka Isozaki, Hiroshi Tsuji, Tadashi Kamada
PURPOSE: The aim of this multi-institutional study was to evaluate the efficacy and safety of carbon-ion radiotherapy (C-ion RT) for locally advanced pancreatic cancer (LAPC). METHODS AND MATERIALS: Patients with LAPC treated with C-ion RT from April 2012 to December 2014 at 3 institutions were retrospectively analyzed. Patients with pathologically-confirmed invasive ductal adenocarcinoma of the pancreas were eligible. The prescribed dose was 52.8 Gy (relative biological effectiveness weighted absorbed dose; RBE) or 55...
May 1, 2018: International Journal of Radiation Oncology, Biology, Physics
Sodai Sakamoto, Yosuke Tsuruga, Yuki Fujii, Hiroki Shomura, Atsuo Hattori, Keizo Kazui
INTRODUCTION: The 2010 World Health Organization classification of intraductal neoplasms of the pancreas includes intraductal tubulopapillary neoplasms (ITPNs) and intraductal papillary mucinous neoplasms, the latter being a rare and new concept. ITPN sometimes cause acute pancreatitis; therefore, distinguishing ITPN from idiopathic acute pancreatitis is important but challenging. PRESENTATION OF CASE: We present the case of a 72-year-old male who had recurrent pancreatitis for the past 2 years, his diagnosis was idiopathic acute pancreatitis...
June 4, 2018: International Journal of Surgery Case Reports
Michelle L Haslinger, Michael Sosin, Alex J Bartholomew, Andrew Crocker, Aiste Gulla, Shawna C Willey, Troy A Pittman, Eleni A Tousimis
BACKGROUND: The aim of this study is to describe a less aggressive approach to management of positive nipple margin following nipple-sparing mastectomy (NSM), allowing for preservation of the nipple-areolar complex (NAC). STUDY DESIGN: A single-institution retrospective chart review was performed for patients undergoing NSM from 1989 to 2017. Positive nipple margin was defined as any residual invasive carcinoma or ductal carcinoma in situ (DCIS) within the additional nipple margin...
June 15, 2018: Annals of Surgical Oncology
Dajiang Song, Zan Li, Xiao Zhou, Yixin Zhang, Xiaowei Peng, Bo Zhou, Chunliu Lü, Wen Peng, Huangxing Mao
Objective: To explore the clinical application of combined transverse upper gracilis flap and adductor magnus perforator flap in breast reconstruction of breast cancer patients after mastectomy. Methods: Between August 2016 and February 2017, the combined transverse upper gracilis flap and adductor magnus perforator flap was used in 12 cases of breast cancer patients who received modified radical surgery for breast reconstruction. All patients were females with the age of 32 to 59 years (mean, 41...
June 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
Chengyong Dong, Ying Liu, Keqiu Jiang, Haibo Wang, Weikun Qu, Chi Zhang, Rui Liang, Zhenming Gao, Baofeng Zhao, Qing Miao, Shujuan Shao, Liming Wang
Nogo-B receptor (NgBR) is a type I receptor with a single transmembrane domain and specifically binds to ligand Nogo-B. A previous study demonstrated that NgBR was highly expressed in human breast invasive ductal carcinoma and promoted epithelial-mesenchymal transition in breast tumor cells. Our recent work found that NgBR expression was associated with a poor prognosis in human patients with hepatocellular carcinoma (HCC). Here, we elucidate that the increased expression of NgBR contributes toward the increased cell growth of human HCC cells both in vitro and in vivo...
June 15, 2018: Journal of Cellular Biochemistry
Demi S Houg, Maarten F Bijlsma
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive malignancies to date, largely because it is associated with high metastatic risk. Pancreatic tumors have a characteristic tendency to metastasize preferentially to the liver. Over the past two decades, it has become evident that the otherwise hostile milieu of the liver is selectively preconditioned at an early stage to render it more conducive to the engraftment and growth of disseminated cancer cells, a concept defined as pre-metastatic niche (PMN) formation...
June 14, 2018: Molecular Cancer
Yongquan Lin, Lihua Rong, Jingrong Zhao, Ronghui Lin, Shuhua Li
MicroRNAs (miRNAs) possess oncogenic and tumour‑suppressive roles in the carcinogenesis and progression of pancreatic ductal adenocarcinoma (PDAC) by regulating the expression of numerous cancer‑related genes. Thus, the investigation on the expression and roles of miRNAs in PDAC may facilitate the identification of novel and effective targets for the clinical diagnosis and treatment of patients with PDAC. miRNA‑539 (miR‑539) has been studied in multiple types of human cancer. However, its expression and potential biological function in PDAC remain unclear...
May 31, 2018: Molecular Medicine Reports
Ji Hyung Hong, Yoon Ho Ko, Keunsoo Kang
Invasive ductal carcinoma is the most common type of breast cancer. Here, we provide a whole transcriptome shotgun sequencing (called RNA-seq) dataset conducted with ten samples of invasive ductal carcinoma tissue and three samples of adjacent normal tissue from a single Korean breast cancer patient (luminal B subtype). Differentially expressed genes (DEGs) were identified with a false discovery rate (FDR)-adjusted p -value of 0.05. Gene ontology analysis identified several key pathways, including lymphocyte activation...
June 2018: Data in Brief
Babak Ehteshami Bejnordi, Maeve Mullooly, Ruth M Pfeiffer, Shaoqi Fan, Pamela M Vacek, Donald L Weaver, Sally Herschorn, Louise A Brinton, Bram van Ginneken, Nico Karssemeijer, Andrew H Beck, Gretchen L Gierach, Jeroen A W M van der Laak, Mark E Sherman
The breast stromal microenvironment is a pivotal factor in breast cancer development, growth and metastases. Although pathologists often detect morphologic changes in stroma by light microscopy, visual classification of such changes is subjective and non-quantitative, limiting its diagnostic utility. To gain insights into stromal changes associated with breast cancer, we applied automated machine learning techniques to digital images of 2387 hematoxylin and eosin stained tissue sections of benign and malignant image-guided breast biopsies performed to investigate mammographic abnormalities among 882 patients, ages 40-65 years, that were enrolled in the Breast Radiology Evaluation and Study of Tissues (BREAST) Stamp Project...
June 13, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
Aude Thouvenot, Yasmine Bizet, Laurent S Baccar, Michele Lamuraglia
Metastasis of non-gynaecological tumours to the cervix is a rare event, and metastasis from breast cancer is even rarer, with only a limited number of such cases reported in the literature to date. We herein report the case of an 86-year-old female patient who had undergone mastectomy and axillary lymphadenectomy for invasive ductal cell breast carcinoma 2 years prior, followed by adjuvant hormonal therapy with letrozole. During hospitalization for anemia associated with an inflammatory syndrome and abdominal pain with menorrhagia, an abdominal ultrasound examination revealed a suspicious uterine mass with irregular contours and abnormal vascularization with associated increase of the blood level of cancer antigen 15-3 to 34 kU/l...
July 2018: Molecular and Clinical Oncology
Chumei Huang, Yaqing Li, Yubo Guo, Zuoquan Zhang, Guoda Lian, Yinting Chen, Jian Li, Yonghui Su, Jiajia Li, Kege Yang, Shaojie Chen, Hong Su, Kaihong Huang, Linjuan Zeng
The molecular mechanism of perineural invasion (PNI) is unclear, and insufficient detection during early-stage PNI in vivo hampers its investigation. We aimed to identify a cytokine paracrine loop between pancreatic ductal adenocarcinoma (PDAC) cells and nerves and established a noninvasive method to monitor PNI in vivo . Methods: A Matrigel/ dorsal root ganglia (DRG) system was used to observe PNI in vitro , and a murine sciatic nerve invasion model was established to examine PNI in vivo . PNI was assessed by MRI with iron oxide nanoparticle labeling ...
2018: Theranostics
Y Liu, M Wang, R Ji, L Cang, F Gao, Y Shi
AIM: To examine whether incorporating magnetic resonance elastography (MRE) with contrast-enhanced computed tomography (CE-CT) or dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) can provide a benefit in differentiating pancreatic ductal adenocarcinoma (PDAC) from inflammatory mass (IM). MATERIALS AND METHODS: Thirty patients with IM and 56 patients with PDAC confirmed by histopathology were identified retrospectively via a prospectively maintained database...
June 9, 2018: Clinical Radiology
Julia L Savage, Deborah O Jeffries, Mitra Noroozian, Michael S Sabel, Julie M Jorns, Mark A Helvie
OBJECTIVE: Pleomorphic lobular carcinoma in situ (PLCIS) is an aggressive subtype of lobular carcinoma in situ treated similarly to ductal carcinoma in situ. The purpose of this study was to determine the imaging findings, upgrade rate of PLCIS at core needle biopsy (CNB), and the treatment and outcomes of these patients. MATERIALS AND METHODS: This retrospective single-institution study included women with PLCIS at CNB or excisional biopsy without concomitant DCIS or invasive carcinoma between January 1, 1999, and July 20, 2016...
June 12, 2018: AJR. American Journal of Roentgenology
Esra Arslan, Tevfik F Çermik, Fadime D C Trabulus, Esra C K Talu, Şerife Başaran
OBJECTIVE: In this study, primary tumors' fluorine-18-fluorodeoxyglucose (F-FDG) uptake in luminal A, luminal B, triple-negative, and human epidermal growth factor receptor type-2 subtypes of breast cancer was evaluated. In addition, the relationship between the primary tumor maximum standardized uptake value (SUVmax) value and the presence of distant metastasis and axillary involvement was evaluated. PATIENTS AND METHODS: Whole-body F-FDG PET/computed tomography (CT) imaging of 493 patients (mean age; 54...
July 2018: Nuclear Medicine Communications
Jun Ni, Yun Peng, Fu-Lan Yang, Xun Xi, Xing-Wei Huang, Chun He
Introduction: The aim of this study was to evaluate the expression of C-type lectin domain family 3 member A (CLEC3A) and its clinical significance in breast invasive ductal cancer (IDC) as well as its effect on breast cancer (BC) cell proliferation and metastasis. In this study, the level of CLEC3A expression in The Cancer Genome Atlas (TCGA) datasets was analyzed. Materials and methods: Clinical collected samples and BC cells were measured using quantitative reverse transcription polymerase chain reaction...
2018: OncoTargets and Therapy
Kelly Kuo, Aaron B Caughey
A 34-year-old primigravid woman presents for a routine prenatal visit at 18 weeks of gestation with a breast lump. On examination, she has a painless, firm breast mass measuring 3-4 cm in diameter with overlying skin dimpling. A diagnostic mammogram shows findings suspicious for malignancy (Breast Imaging Reporting and Data System [BI-RADS] 4), and core biopsy demonstrates an invasive ductal carcinoma with both estrogen and progesterone receptor-positive staining. The patient asks: "How will this affect my pregnancy, and what is the safest course of action?"...
June 6, 2018: Obstetrics and Gynecology
Mengzhe Wang, He Zhang, Hui Wang, Huijuan Feng, Huaifu Deng, Zhanhong Wu, Hongjian Lu, Zi-Bo Li
Several studies have suggested that neurotensin receptors (NTRs) and neurotensin (NT) greatly affect the growth and survival of pancreatic ductal adenocarcinoma (PDAC). Developing NTR targeted PET probes could therefore be important for the management of pancreatic cancer patient by providing key information on NTR expression profile non-invasively. Despite the initial success on the synthesis of 18F labeled NT PET probes, the labeling procedure generally requires lengthy steps include azeotropic drying of 18F...
June 11, 2018: Molecular Pharmaceutics
J Y Liu, L P Zou, H J Wu, Z H Zhao, Z G Zhang
Objective: To investigate the expression and significance of ubiquitin-specific proteases 2-69(USP2-69) in invasive ductal carcinoma of breast. Methods: Twenty-four cases of human breast tissue with invasive ductal carcinoma diagnosed at Huanshan Hospital, Fudan University from 2013 to 2015 were collected, and the expression of USP2-69 mRNA and protein was detected by molecular hybridization, Western blot and immunohistochemistry. USP2-69 was over-expressed in cultured human breast cancer cell line MCF-7 by USP2-69 plasmid transfection...
June 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
Sang Hyun Shin, Song Cheol Kim, Ki-Byung Song, Dae Wook Hwang, Jae Hoon Lee, Kwang-Min Park, Young-Joo Lee
BACKGROUND: To identify chronologic changes in clinical and survival features of pancreatic ductal adenocarcinoma based on diagnosis and treatment strategy development since 2000. METHODS: Among 2,029 patients enrolled in this study, 746 and 1,283 were treated between 2000 and 2009 (group 1) and between 2010 and 2016 (group 2), respectively. We used patient clinicopathologic, biologic, and molecular factors to assess the prognostic factors. RESULTS: Group 2 had a better survival outcome than group 1 (median survival time: 24...
June 5, 2018: Surgery
Rüdiger Schulz-Wendtland, Caroline Preuss, Peter A Fasching, Christian R Loehberg, Michael P Lux, Julius Emons, Matthias W Beckmann, Michael Uder, Markus Mueller-Schimpfle
Introduction: For decades, conventional galactography was the only imaging technique capable of showing the mammary ducts. Today, diagnosis is based on a multimodal concept which combines high-resolution ultrasound with magnetic resonance (MR) mammography and ductoscopy/galactoscopy and has a sensitivity and specificity of up to 95%. This study used tomosynthesis in galactography for the first time and compared the synthetic digital 2D full-field mammograms generated with this technique with the images created using the established method of ductal sonography...
May 2018: Geburtshilfe und Frauenheilkunde
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