Min Xiao, Song Yang, An Zhou, Tongxin Li, Jingjing Liu, Yang Chen, Ya Luo, Chunfang Qian, Fuping Yang, Bo Tang, Chunhua Li, Na Su, Jing Li, Mingying Jiang, Shiming Yang, Hui Lin
Background: MicroRNAs (miRNAs) play a vital role in tuberculosis (TB). Vitamin D receptor (VDR), an miRNA target gene, and its ligand, vitamin D3 (VitD3 ), have been reported to exert protective effects against TB. However, whether miRNAs can affect the progression of TB by targeting VDR has not been reported. Materials and methods: Research subjects were selected according to defined inclusion criteria. A clinical database of 360 samples was established, including the subjects' demographic information, miRNA expression profiles and cellular experimental results...
2022: Frontiers in Microbiology