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https://www.readbyqxmd.com/read/29401596/prostaglandin-e-2-suppresses-hcap18-ll-37-expression-in-human-macrophages-via-ep2-ep4-implications-for-treatment-of-mycobacterium-tuberculosis-infection
#1
Min Wan, Xiao Tang, Rokeya Sultana Rekha, S S V Jagadeeswara Rao Muvva, Susanna Brighenti, Birgitta Agerberth, Jesper Z Haeggström
Prostaglandin (PG)E2 is an arachidonic acid-derived lipid mediator that plays an important role in inflammation and immunity. In this study, we demonstrate that PGE2 suppresses basal and 1,25-dihydroxy vitamin D3 (VD3 )-induced expression of hCAP18/LL-37 via E prostanoid (EP)2 and EP4 receptors. In humans, VD3 up-regulates vitamin D receptor (VDR) expression and promotes transcription of the cathelicidin hCAP18/LL-37 gene, whereas PGE2 counteracts this effect. We find that PGE2 induces the cAMP/PKA-signaling pathway and enhances the expression of the inhibitory transcription factor cAMP-responsive modulator/inducible cAMP early repressor, which prevents VDR expression and induction of hCAP18/LL-37 in human macrophages...
May 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29289621/high-dose-of-vitamin-d-supplement-is-associated-with-reduced-susceptibility-of-monocyte-derived-macrophages-to-dengue-virus-infection-and-pro-inflammatory-cytokine-production-an-exploratory-study
#2
Diana Marcela Giraldo, Andrés Cardona, Silvio Urcuqui-Inchima
BACKGROUND: Dengue, one the most important public health problems in tropical and subtropical areas, is the most important mosquito-borne viral infection in humans. In the absence of effective treatment and vaccine against dengue, the active form of vitamin D could play a central role in protection against dengue virus (DENV), the causal agent of dengue. Recently we reported that monocyte-derived macrophages (MDMs) differentiated in the presence of vitamin D, in addition to expressing lower levels of mannose receptor, are less susceptible to DENV infection and produce low levels of pro-inflammatory cytokines, compared to MDMs differentiated in the absence of vitamin D...
March 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29150278/a-hypothetical-role-for-notch-signaling-pathway-in-immunopathogenesis-of-leprosy
#3
Héctor Serrano-Coll, Liliana Acevedo-Saenz, Nora Cardona-Castro
Leprosy is a chronic infectious disease caused by Mycobacterium leprae mainly affecting skin and peripheral nerves. Leprosy has a broad range of clinical manifestations that range from mild (tuberculoid leprosy) to severe (lepromatous leprosy) forms, and are highly dependent on the host's immune response. Among the immune response elements involved in the pathogenesis of leprosy are the Toll-like receptors (TLRs), vitamin D receptor (VDR), natural killer cells (NK), and T cells. These innate and adaptive immune response elements may be related to the Notch signaling pathway, which is involved in immune cell growth, differentiation, and proliferation...
November 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/29074824/-update-on-recent-progress-in-vitamin-d-research-vitamin-d-and-bone-mineral-metabolism
#4
REVIEW
Ritsuko Masuyama
Vitamin D endocrine system is required for bone and mineral homeostasis through the active form of vitamin D[1α,25(OH)2 D3 ]transported to the target organs, where the vitamin D receptor(VDR)is present. The biological significance of 1α,25(OH)2 D3 -VDR signalling is regarded not only in classical target of vitamin D involved in calcium and phosphate homeostasis, such as intestine, bone, kidney and parathyroid glands, but also in many other non-classical target cells of vitamin D including skin keratinocytes, pancreatic β cells, cardiomyocytes, T-lymphocytes, bone marrow macrophages, among others...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28959253/methylation-of-the-vitamin-d-receptor-vdr-gene-together-with-genetic-variation-race-and-environment-influence-the-signaling-efficacy-of-the-toll-like-receptor-2-1-vdr-pathway
#5
Vanessa Meyer, Donovan Sean Saccone, Fidele Tugizimana, Furaha Florence Asani, Tamsyn Jacki Jeffery, Liza Bornman
BACKGROUND: The disparity in prevalence of infectious diseases across the globe is common knowledge. Vitamin D receptor (VDR)-mediated toll-like receptor (TLR) 2/1 signaling produces antimicrobial peptides, which is critical as a first line of defense in innate immunity. Numerous studies disclosed the independent role of genetic polymorphisms in this pathway, vitamin D status or season and more recently epigenetics, as factors contributing to infectious disease predisposition. Few studies address the interaction between environment, genetics, and epigenetics...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28891930/vitamin-d-receptor-gene-polymorphisms-associated-with-childhood-autism
#6
Anna Cieślińska, Elżbieta Kostyra, Barbara Chwała, Małgorzata Moszyńska-Dumara, Ewa Fiedorowicz, Małgorzata Teodorowicz, Huub F J Savelkoul
BACKGROUND: Autism spectrum disorder (ASD) is a group of heterogeneous, behaviorally defined disorders whereby currently no biological markers are common to all affected individuals. A deregulated immune response may be contributing to the etiology of ASD. The active metabolite of vitamin D₃ has an immunoregulatory role mediated by binding to the vitamin D receptor (VDR) in monocyte, macrophages, and lymphocytes. The effects of vitamin D and interaction with the VDR may be influenced by polymorphism in the VDR gene...
September 9, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28774952/vitamin-d-supplementation-of-initially-vitamin-d-deficient-mice-diminishes-lung-inflammation-with-limited-effects-on-pulmonary-epithelial-integrity
#7
Shelley Gorman, Alysia G Buckley, Kak-Ming Ling, Luke J Berry, Vanessa S Fear, Stephen M Stick, Alexander N Larcombe, Anthony Kicic, Prue H Hart
In disease settings, vitamin D may be important for maintaining optimal lung epithelial integrity and suppressing inflammation, but less is known of its effects prior to disease onset. Female BALB/c dams were fed a vitamin D3-supplemented (2280 IU/kg, VitD(+)) or nonsupplemented (0 IU/kg, VitD(-)) diet from 3 weeks of age, and mated at 8 weeks of age. Male offspring were fed the same diet as their mother. Some offspring initially fed the VitD(-) diet were switched to a VitD(+) diet from 8 weeks of age (VitD(-/+))...
August 2017: Physiological Reports
https://www.readbyqxmd.com/read/28710799/high-glucose-induces-o-glcnac-glycosylation-of-the-vitamin-d-receptor-vdr-in-thp1-cells-and-in-human-macrophages-derived-from-monocytes
#8
Fernando Hernández-Sánchez, Silvia Guzmán-Beltrán, María Teresa Herrera, Yolanda Gonzalez, Manuel Salgado, Guadalupe Fabian, Martha Torres
Chronic hyperglycemia increases the carbon flux through the hexosamine pathway, allowing the accumulation of UDP-GlcNAc. UDP-GlcNAc is the sugar donor for the enzyme-mediated protein glycosylation event known as OGlcNAcylation. This posttranslational modification targets several transcription factors implicated in glucose toxicity, insulin resistance, and diabetes. Vitamin D plays an important role in glucose homeostasis and insulin secretion through transcriptional mechanisms mediated by its receptor (VDR)...
July 15, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28669663/1-25-oh-2-vitamin-d-3-contributes-to-osteoclast-like-trans-differentiation-of-malignant-plasma-cells
#9
Paola Cafforio, Stella D'Oronzo, Claudia Felici, Sandra Sigala, Martina Fragni, Francesco Silvestris
1,25-dihydroxyvitamin D (1,25(OH)2 D) exerts pleiotropic effects including bone turnover and immune system regulation. It inhibits both T and B cell proliferation while decreasing the secretion of inflammatory cytokines and immunoglobulins. 1,25(OH)2 D also modulates monocyte-macrophage and osteoclast (OC) maturation. Since we have previously described that malignant plasma cells may trans-differentiate towards the myeloid lineage participating to skeletal devastation in multiple myeloma (MM), we here evaluated in vitro the role of 1,25(OH)2 D in this lineage switch...
September 15, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28662432/cathelicidin-augments-vdr-dependent-anti-leishmanial-immune-response-in-indian-post-kala-azar-dermal-leishmaniasis
#10
Sushmita Das, Abul Hasan Sardar, Kumar Abhishek, Ajay Kumar, Vidya Nand Rabidas, Pradeep Das
OBJECTIVES: Indian Post kala-azar dermal leishmaniasis (PKDL) is the cutaneous aftermath of visceral leishmaniasis (VL) caused by L. donovani. Vitamin D-regulated cationic antimicrobial peptide cathelicidin (hCAP-18/LL-37) has microbicidal and immunomodulatory role against cutaneous infections, but its role in PKDL remains elusive. METHODS: Skin snips and blood-derived monocytes of PKDL patients (n=46), before (BT) and after (AT) chemotherapy, were used for this study...
June 26, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28368514/vitamin-d-receptor-dependent-signaling-protects-mice-from-dextran-sulfate-sodium-induced-colitis
#11
Fa Wang, Robert L Johnson, Marsha L DeSmet, Paul W Snyder, Keke C Fairfax, James C Fleet
Low vitamin D status potentiates experimental colitis, but the vitamin D-responsive cell in colitis has not been defined. We hypothesized that vitamin D has distinct roles in colonic epithelial cells and in nonepithelial cells during colitis. We tested this hypothesis by using mice with vitamin D receptor (VDR) deletion from colon epithelial cells (CEC-VDRKO) or nonintestinal epithelial cells (NEC-VDRKO). Eight-week-old mice were treated with 1.35% dextran sulfate sodium (DSS) for 5 days and then euthanized 2 or 10 days after removal of DSS...
June 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28054069/challenge-and-perspective-the-relevance-of-ultraviolet-uv-radiation-and-the-vitamin-d-endocrine-system-vdes-for-psoriasis-and-other-inflammatory-skin-diseases
#12
Jörg Reichrath, Roman Saternus, Thomas Vogt
During evolution, the ability of many organisms to synthesize vitamin D photochemically represented, and still represents, a major driving factor for the development of life on earth. In humans because not more than 10-20% of the requirement of vitamin D can be satisfied by the diet (under most living conditions in the US and Europe), the remaining 80-90% need to be photochemically synthesized in the skin through the action of solar or artificial ultraviolet-B (UV-B) radiation. The skin is a key organ of the human body's vitamin D endocrine system (VDES), representing both the site of vitamin D synthesis and a target tissue for biologically active vitamin D metabolites...
March 16, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/27856242/1-25-oh-2-d-3-induced-interaction-of-vitamin-d-receptor-with-p50-subunit-of-nf-%C3%AE%C2%BAb-suppresses-the-interaction-between-klf5-and-p50-contributing-to-inhibition-of-lps-induced-macrophage-proliferation
#13
Dong Ma, Ruo-Nan Zhang, Ya Wen, Wei-Na Yin, Disi Bai, Guo-Ying Zheng, Jin-Shui Li, Bin Zheng, Jin-Kun Wen
KLF5 and nuclear factor κB (NF-κB) regulate cell proliferation and inflammation. Vitamin D signaling through vitamin D receptor (VDR) exerts anti-proliferative and anti-inflammatory actions. However, an actual relationship between KLF5, NF-κB and VDR in the inflammation and proliferation of macrophages is still unclear. Here, we showed that LPS and proinflammatory cytokines stimulate KLF5 gene expression in macrophages, and that 1, 25(OH)2 D3 suppresses LPS-induced KLF5 expression and cell proliferation via upregulation of VDR expression...
January 8, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27785371/vitamin-d-receptor-expression-in-human-bone-tissue-and-dose-dependent-activation-in-resorbing-osteoclasts
#14
Allahdad Zarei, Alireza Morovat, Kassim Javaid, Cameron P Brown
The effects of vitamin D on osteoblast mineralization are well documented. Reports of the effects of vitamin D on osteoclasts, however, are conflicting, showing both inhibition and stimulation. Finding that resorbing osteoclasts in human bone express vitamin D receptor (VDR), we examined their response to different concentrations of 25-hydroxy vitamin D3 [25(OH)D3 ] (100 or 500 nmol · L-1 ) and 1,25-dihydroxy vitamin D3 [1,25(OH)2 D3 ] (0.1 or 0.5 nmol · L-1 ) metabolites in cell cultures. Specifically, CD14+ monocytes were cultured in charcoal-stripped serum in the presence of receptor activator of nuclear factor kappa-B ligand (RANKL) and macrophage colony-stimulating factor (M-CSF)...
2016: Bone Research
https://www.readbyqxmd.com/read/27779898/reflections-about-inflammatory-bowel-disease-and-vitamins-a-and-d
#15
REVIEW
Sandra Maria Barbalho, Marcelo Dib Bechara, Ricardo de Alvares Goulart, Karina Quesada, Rodrigo Galhardi Gasparini, Antonely de Cássio Alves de Carvalho, Adriana Maria Ragassi Fiorini
Ulcerative colitis and Crohn's disease are two major forms of the inflammatory bowel diseases (IBDs). Vitamin A (VA) and vitamin D (VD) may be associated with reduction in inflammation in these disorders. The aim of this review was to show the current evidence that may associate VA and VD with IBDs. Data linking VA, VD, and IBDs were studied. Both VA and VD may be related to the immune system in different manners. The active form of VA, retinoic acid, may be related to the growth factor-β and release of interleukin-10 (IL-10), thus involved with the resolution of the inflammation...
December 2016: Journal of Medicinal Food
https://www.readbyqxmd.com/read/27595605/vitamin-d-receptor-gene-associations-with-pulmonary-tuberculosis-in-a-tibetan-chinese-population
#16
Qunying Hu, Zhengshuai Chen, Guinian Liang, Fangping Mo, Hengxun Zhang, Shilin Xu, Yuhe Wang, Longli Kang, Tianbo Jin
BACKGROUND: The vitamin D receptor (VDR) mediates the immunological function of vitamin D3, which activates macrophages, and vitamin D deficiency has been linked to tuberculosis risk. Single nucleotide polymorphisms (SNPs) in VDR may influence the function of vitamin D and susceptibility to tuberculosis. METHODS: This study included 217 patients with pulmonary tuberculosis (PTB) and 383 healthy subjects in a Tibetan Chinese population living in and near Xi'an. Association analyses of SNPs in VDR were performed with the SPSS 17...
September 5, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27588937/vitamin-d-mediated-hypercalcemia-mechanisms-diagnosis-and-treatment
#17
REVIEW
Peter J Tebben, Ravinder J Singh, Rajiv Kumar
Hypercalcemia occurs in up to 4% of the population in association with malignancy, primary hyperparathyroidism, ingestion of excessive calcium and/or vitamin D, ectopic production of 1,25-dihydroxyvitamin D [1,25(OH)2 D], and impaired degradation of 1,25(OH)2 D. The ingestion of excessive amounts of vitamin D3 (or vitamin D2 ) results in hypercalcemia and hypercalciuria due to the formation of supraphysiological amounts of 25-hydroxyvitamin D [25(OH)D] that bind to the vitamin D receptor, albeit with lower affinity than the active form of the vitamin, 1,25(OH)2 D, and the formation of 5,6-trans 25(OH)D, which binds to the vitamin D receptor more tightly than 25(OH)D...
October 2016: Endocrine Reviews
https://www.readbyqxmd.com/read/27561793/1-25-oh-2-d-3-improves-cardiac-dysfunction-hypertrophy-and-fibrosis-through-parp1-sirt1-mtor-related-mechanisms-in-type-1-diabetes
#18
Hua Qu, Ke Lin, Hang Wang, Huili Wei, Baolan Ji, Zengsong Yang, Chuan Peng, Xiaoqiu Xiao, Huacong Deng
SCOPE: Diabetic cardiomyopathy is one of the most important cardiac complications associated with diabetes. However, the mechanisms underlying diabetic cardiomyopathy remain unclear. The PARP1, SIRT1, and mTOR pathways have been implicated in cardiac diseases, and they are also associated with diabetes. 1,25(OH)2 D3 was recently recognized as a potential PARP1inhibitor in a macrophage cell line. The aim of our study was to investigate whether 1,25(OH)2 D3 can improve diabetic cardiomyopathy through a vitamin D receptor (VDR)-dependent mechanism associated with the PARP1/SIRT1/mTOR pathway...
May 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27555526/vitamin-d-receptor-is-expressed-within-human-carotid-plaques-and-correlates-with-pro-inflammatory-m1-macrophages
#19
Federico Carbone, Nathalie Satta, Fabienne Burger, Aline Roth, Sébastien Lenglet, Sabrina Pagano, Pierre Lescuyer, Maria Bertolotto, Giovanni Spinella, Bianca Pane, Domenico Palombo, Aldo Pende, Franco Dallegri, François Mach, Nicolas Vuilleumier, Fabrizio Montecucco
The role of Vitamin D system in cardiovascular diseases remains controversial. Here, we investigated whether intraplaque levels of vitamin D receptor (VDR) predicted major adverse cardiovascular events (MACEs) at 18month-follow-up and correlated with macrophage subsets in 164 patients undergoing endarterectomy for carotid stenosis. In human carotid plaque portions upstream and downstream the blood flow, VDR, lipid, collagen, as well as macrophage subsets were determined. Human primary monocytes were then differentiated in vitro to M1 and M2 macrophages and treated with 1,25(OH)2D3...
October 2016: Vascular Pharmacology
https://www.readbyqxmd.com/read/27530414/vitamin-d-machinery-and-metabolism-in-porcine-adipose-derived-mesenchymal-stem-cells
#20
Yovani Llamas Valle, Sami G Almalki, Devendra K Agrawal
BACKGROUND: Vitamin D, a hormone once thought to have a role limited to calcium homeostasis and bone mineralization, has pleiotropic effects on different types of cells. Vitamin D receptors are reported in vascular smooth muscle cells, endothelial cells, and cardiomyocytes. Adipose-derived MSCs (ADMSCs) are multipotent cells with the capacity to differentiate into cells of different lineages. To our knowledge, the presence of vitamin D machinery on porcine ADMSCs has not yet been examined...
August 17, 2016: Stem Cell Research & Therapy
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