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JOURNAL ARTICLE
Zhen Li, Yuan Du, Chen Ding, Pufan Yang, Lin Wang, Yan Zhao
The active ingredient group is a prominent feature reflecting the inherent characteristics of plant-based functional foods. Chinese hawthorn leaf (CHL), a tea substitute possessing intrinsic nutritional properties in anti-hyperlipidemia, was first found to be adulterated with Malus doumeri leaf (MDL) owing to similar commercial labels. In this context, the above-mentioned two contrasting species were explored through phytochemical profiling and activity assessment. The amelioration effect of CHL on free fatty acids-elicited lipid deposition in HepG2 cells was significantly better than that of MDL...
March 2024: Plant Foods for Human Nutrition
#22
JOURNAL ARTICLE
Qianlu Zheng, Nathaniel Hawthorne, James D Batteas, Rosa M Espinosa-Marzal
Ionic liquids (ILs) are a promising class of lubricants that allow dynamic friction control at electrified interfaces. In the real world, surfaces inevitably exhibit some degree of roughness, which can influence lubrication. In this work, we deposited single-layer graphene onto 20 nm silica nanoparticle films to investigate the effect of surface curvature and electrostatic potential on both the lubricious behavior and interfacial layering structure of 1-ethyl-3-methyl imidazolium bis(trifluoromethylsulfonyl)imide on graphene...
February 9, 2024: Langmuir: the ACS Journal of Surfaces and Colloids
#23
JOURNAL ARTICLE
Jing Yang, Jialin Gu, Ying Shen, Ling Cao, Hong Zhou, Wei Zhu
BACKGROUND: Shan Zha (Hawthorn or Crataegus) is a traditional Chinese medicine (TCM) most commonly used for the treatment of hyperlipidemia. Gastrointestinal cancer is closely correlated with blood lipid levels. This study illustrates the potential anticancer effects of Shan Zha on gastrointestinal tumors based on network pharmacology and molecular docking. METHODS: Hawthorn's bioactive ingredients and drug targets were obtained from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), Integrative Pharmacology-based Research Platform of Traditional Chinese Medicine version 2...
October 2023: Cancer Pathog Ther
#24
JOURNAL ARTICLE
Ying Yuan, Ziqi Chai, Yuxue Zheng, Yanming Ren, Xingqian Ye, Xiangli Kong, Jinhu Tian
To investigate the effect of hawthorn polyphenols on the physicochemical properties and digestibility of corn starch, different proportions (1%, 2%, 3%, and 4% [w/w]) of hawthorn polyphenol extracts (HPEs) were mixed with corn starch, and their physicochemical properties and digestive properties were characterized by X-ray diffraction, Fourier transform infrared spectroscopy, Rapid Visco Analysis, differential scanning calorimetry, and in vitro/in vivo analysis. Results indicated that small V-type crystal starch tended to be formed in the samples, and the addition of HPEs reduced the viscosity, prolonged the gelatinization temperature of corn starch, and increased the proportion of slowly digestible starch and resistant starch of the corn starch, which accounted for 36...
January 23, 2024: Journal of Food Science
#25
JOURNAL ARTICLE
Matteo De Simone, Rosario De Feo, Anis Choucha, Elena Ciaglia, Francis Fezeu
Sleep is essential for overall health, yet various sleep disorders disrupt normal sleep patterns, affecting duration, quality, and timing. This pilot study investigate the impact of a food supplement (SPINOFF® ) on both sleep quality and mental well-being in 41 participants (mean age: 45.3 years). Initial assessments revealed sleep disturbances (Pittsburgh Sleep Quality Index-PSQ-mean score: 8.2) and insomnia symptoms (Insomnia Severity Index-ISI- mean score: 12.7). Mental health assessments showed psychological distress (Dass-21 Depression mean score: 4...
December 28, 2023: Medical Sciences: Open Access Journal
#26
JOURNAL ARTICLE
Yu Bi, Chang Lv, Juanjuan Zhu, Qiao Zhou, Xiaoxiao Xu, Shuo Yang, Dianhua Shi, Qian Zhou, Yanpeng Dai
Obesity (OB) is a prevalent metabolic disorder. With the advancement of the economy, the prevention and treatment of obesity is a big problem for the global community. The methods to lose weight include exercise, diet, medicine, and surgery. Compared with other methods, diet regulation is safer and more effective. Hawthorn fruit has the effect of reducing weight, but the mechanism of effectiveness are not clear. In this study, obesity model rats are used to conduct scientific pharmacological research on hawthorn flavonoids...
January 12, 2024: Advanced biology
#27
JOURNAL ARTICLE
Alison E Fowler, Quinn S McFrederick, Lynn S Adler
Pollinators face many stressors, including reduced floral diversity. A low-diversity diet can impair organisms' ability to cope with additional stressors, such as pathogens, by altering the gut microbiome and/or immune function, but these effects are understudied for most pollinators. We investigated the impact of pollen diet diversity on two ecologically and economically important generalist pollinators, the social bumble bee (Bombus impatiens) and the solitary alfalfa leafcutter bee (Megachile rotundata)...
January 2, 2024: Microbial Ecology
#28
REVIEW
Yuan Sun, Xianwei Meng, Mengjie Chen, Dan Li, Rui Liu, Tiedong Sun
ETHNOPHARMACOLOGIC RELEVANCE: Crataegus pinnatifida, commonly known as hawthorn, is a plant species with a long history of medicinal use in traditional Chinese medicine. Hawthorn polysaccharides (HP) have gained worldwide attention due to their decent biological activities and potential health benefits. Their excellent antioxidant activity, antitumor activity, immunomodulatory activity, hypoglycemic effect and hypolipidemic effects, intestinal microbiota modulatory activity makes them valuable in the field of ethnopharmacological research...
April 6, 2024: Journal of Ethnopharmacology
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JOURNAL ARTICLE
Gabriel Ferri, Lucía R Fernández, Guillermo Di Mario, Daniel Musikant, Jorge A Palermo, Martin M Edreira
Although the two drugs currently available for the treatment of Chagas disease, Benznidazole and Nifurtimox, have proven to be effective in the acute phase of the disease, the 60-90-day treatment leads to high toxicity and unwanted side effects, presenting, in addition, a low efficacy in the chronic phase of the disease. For this reason, new therapies that are more effective are needed. In this regard, we have recently shown that the inhibition of the Epac-Rap1b pathway suppressed the cAMP-mediated host cell invasion by Trypanosoma cruzi ...
2023: Frontiers in Microbiology
#30
JOURNAL ARTICLE
Majda Bakali, Thomas Cj Ward, Enya Daynes, Amy V Jones, Grace M Hawthorne, Lorna Latimer, Pip Divall, Matt Graham-Brown, Gerry P McCann, Thomas Yates, Michael C Steiner, Rachael Andrea Evans
RATIONALE: There is conflicting evidence whether aerobic exercise training (AET) reduces pulse wave velocity (PWV) in adults with and without long-term conditions (LTCs). OBJECTIVE: To explore whether PWV improves with AET in adults with and without LTC, to quantify the magnitude of any effect and understand the influence of the exercise prescription. DATA SOURCES: CENTRAL, MEDLINE and EMBASE were among the databases searched. ELIGIBILITY CRITERIA: We included studies with a PWV measurement before and after supervised AET of at least 3 weeks duration...
December 14, 2023: Open Heart
#31
JOURNAL ARTICLE
Leo Marcoff, Konstantinos Koulogiannis, Lilian Aldaia, Anuj Mediratta, Scott M Chadderdon, Moody M Makar, Tobias Friedrich Ruf, Theresa Gößler, Jonathan G Zaroff, Gordon K Leung, Ivy A Ku, Michael Nabauer, Paul A Grayburn, Zuyue Wang, Katie M Hawthorne, Dale E Fowler, Jacob P Dal-Bianco, Mani A Vannan, Carmine Bevilacqua, Massimiliano Meineri, Joerg Ender, Anna Flo Forner, Jyothy J Puthumana, Atizazul Hassan Mansoor, Dustin J Lloyd, Steven J Voskanian, Andrew Ghobrial, Rebecca T Hahn, Feroze Mahmood, Christiane Haeffele, Geraldine Ong, Leonhard Moritz Schneider, Dee Dee Wang, Nishant K Sekaran, Elana Koss, Priti Mehla, Serge Harb, Rhonda Miyasaka, Maria Ivannikova, Terri Stewart-Dehner, Lucas Mitchel, Sasan R Raissi, Daniel Kalbacher, Santanu Biswas, Edwin C Ho, Ythan Goldberg, Robert L Smith, Jörg Hausleiter, D Scott Lim, Linda D Gillam
BACKGROUND: The CLASP IID randomized trial (Edwards PASCAL TrAnScatheter Valve RePair System Pivotal Clinical Trial; NCT03706833) demonstrated the safety and effectiveness of the PASCAL system for mitral transcatheter edge-to-edge repair (M-TEER) in patients at prohibitive surgical risk with significant symptomatic degenerative mitral regurgitation (DMR). OBJECTIVES: This study describes the echocardiographic methods and outcomes from the CLASP IID trial and analyzes baseline variables associated with residual mitral regurgitation (MR) ≤1+...
December 1, 2023: JACC. Cardiovascular Imaging
#32
RANDOMIZED CONTROLLED TRIAL
L E J Peeters, T van Gelder, L van Dijk, B C P Koch, J Versmissen
PURPOSE: Hypertension significantly contributes to cardiovascular diseases and premature deaths. Effective treatment is crucial to reduce cardiovascular risks, but poor adherence to antihypertensive drugs is a major issue. Numerous studies attempted to investigate interventions for identifying non-adherence, but often failed to address the issue effectively. The RHYME-RCT trial sought to bridge this gap by measuring non-adherence by determining antihypertensive drug concentrations in blood through a dried blood spot (DBS) method in patients with resistant hypertension...
December 2023: Blood Pressure
#33
James Espinosa, Robert Bassett, Alan Lucerna, Darren Finn
Here we present the case of a patient who purchased a Hawthorne root (Crataegus mexicana) product, Raiz de Tejocote, for weight loss purposes. She presented with diffuse myalgias, dizziness and a heart rate of 52 beats per minute. At triage and at initial evaluation, the patient denied taking any medications, but on iterative questioning concerning over-the-counter, over-the-internet and herbal medications, she reported taking Hawthorne root tablets in the three days prior to the emergency department (ED) visit for the purpose of weight loss...
November 3, 2023: American Journal of Emergency Medicine
#34
JOURNAL ARTICLE
Evelyn J Salvaris, Nella Fisicaro, Stephen McIlfatrick, Adwin Thomas, Erin Fuller, Andrew M Lew, Mark B Nottle, Wayne J Hawthorne, Peter J Cowan
BACKGROUND: Pig islet xenotransplantation is a potential treatment for type 1 diabetes. We have shown that maintenance immunosuppression is required to protect genetically modified (GM) porcine islet xenografts from T cell-mediated rejection in baboons. Local expression of a depleting anti-CD2 monoclonal antibody (mAb) by the xenograft may provide an alternative solution. We have previously reported the generation of GGTA1 knock-in transgenic pigs expressing the chimeric anti-CD2 mAb diliximab under an MHC class I promoter (MHCIP)...
November 13, 2023: Xenotransplantation
#35
JOURNAL ARTICLE
Brendan P Stewart, Benjamin C Hawthorne, Caitlin G Dorsey, Ian J Wellington, Mark Cote, Augustus Mazzocca
INTRODUCTION: The incidence of reverse shoulder arthroplasty (RTSA) in the United States has increased. Patients under 60 years old with failed rotator cuff repairs or degenerative joint disease with glenoid deformity may be candidates for RTSA and contribute to this increase. The single assessment numeric evaluation (SANE) score is a reliable post-operative scoring technique when compared with other post-operative measures. This study aimed to compare the effect of age on the likelihood of reaching clinically significant SANE scores following RTSA...
October 2023: Curēus
#36
JOURNAL ARTICLE
Yunxia Cheng, Zhenying Liu, Bo Xu, Pingping Song, Zhimao Chao
Hawthorn, the sliced and dried ripe fruits of Crataegus pinnatifida Bge. Var. Major N. E. Br. (Rosaceae), is an edible and medicinal substance with a variety of health-promoting benefits. Hawthorn needs to be stored in warehouses after harvesting to meet people's perennial demand. However, it is easily infested by insects of Plodia interpunctella and Tribolium castaneum during storage, which inevitably leads to poor quality and causes adverse effects on people's health. So far, there has been no report on insect-infested hawthorn...
2023: Current research in food science
#37
JOURNAL ARTICLE
David M Poché, Donald Wagner, Noah Hawthorne, Batchimeg Tseveenjav, Richard M Poché
Lyme disease is the most prevalent vector-borne disease in the U.S., and acaricidal feeds administered to white-tailed deer ( Odocoileus virginianus ) have potential to disrupt blood feeding by the blacklegged tick, Ixodes scapularis . Two studies were conducted with the aim of determining an ideal formulation to deliver oral acaricides to white-tailed deer and finding the lowest fipronil dose level to effectively control I. scapularis . During formulation screening, various commercial attractants (baits) were presented to deer in large paddocks under semi-field conditions and motion-sensitive cameras were used to monitor consumption by deer and non-target species...
December 2023: Journal of Vector Ecology
#38
JOURNAL ARTICLE
Kubra Unal, Ali Samet Babaoğlu, Mustafa Karakaya
This study was designed to investigate the effects of vinegar-based marinades on pH, technological properties, color, microstructure, texture, and sensory characteristics of 9-year-old Holstein meat which had tough texture. To marinate the Longissimus lumborum steaks, three different marinades were prepared depending on the different additions of vinegar: black chokeberry (BV), grape (GV), and hawthorn vinegars (HV). The group with water (without vinegar) was prepared as a control sample (C). The steak samples were dipped into the vinegar-based marinades and stored at 4°C for 24 h...
October 2023: Food Science & Nutrition
#39
JOURNAL ARTICLE
Wael M Khamis, Said I Behiry, Samy A Marey, Abdulaziz A Al-Askar, Ghoname Amer, Ahmed A Heflish, Yiming Su, Ahmed Abdelkhalek, Mohamed K Gaber
Fungicides or insecticides are popular means of controlling a variety of pathogens and insect pests; however, they can cause harmful effects on both human health and the environment. Different researchers have suggested using plant extracts, which have shown promise in managing fungi and insects. The purpose of this investigation was to explore the antifungal activities of an acetone extract made from the leaves of Indian Hawthorn (HAL) against phytopathogens that are known to harm maize crops, Fusarium verticillioides (OQ820154) and Rhizoctonia solani (OQ820155), and to evaluate the insecticidal property against Aphis gossypii Glover aphid...
October 11, 2023: Scientific Reports
#40
JOURNAL ARTICLE
Mahsa Taghiakbari, Diana Elena Coman, Mark Takla, Alan Barkun, Mickael Bouin, Simon Bouchard, Eric Deslandres, Sacha Sidani, Daniel von Renteln
Background and study aims An independent observer can improve procedural quality. We evaluated the impact of the observer (Hawthorne effect) on important quality metrics during colonoscopies. Patients and Methods In a single-center comparative study, consecutive patients undergoing routine screening or diagnostic colonoscopy were prospectively enrolled. In the index group, all procedural steps and quality metrics were observed and documented, and the procedure was video recorded by an independent research assistant...
September 2023: Endoscopy International Open
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