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https://www.readbyqxmd.com/read/28703045/the-role-of-human-host-genetics-in-tuberculosis-resistance
#1
Craig Kinnear, Eileen G Hoal, Haiko Schurz, Paul D van Helden, Marlo Möller
Tuberculosis (TB) remains a public health problem: the latest estimate of new incident cases per year is a staggering 10.4 million. Despite this overwhelming number, the majority of the immunocompetent population can control infection with Mycobacterium tuberculosis. The human genome underlies the immune response and contributes to the outcome of TB infection. Areas covered: Investigations of TB resistance in the general population have closely mirrored those of other infectious diseases and initially involved epidemiological observations...
July 20, 2017: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/28700743/polymorphisms-in-the-vitamin-d-receptor-gene-are-associated-with-reduced-rate-of-sputum-culture-conversion-in-multidrug-resistant-tuberculosis-patients-in-south-africa
#2
Matthew J Magee, Yan V Sun, James C M Brust, N Sarita Shah, Yuming Ning, Salim Allana, Angela Campbell, Qin Hui, Koleka Mlisana, Pravi Moodley, Neel R Gandhi
BACKGROUND: Vitamin D modulates the inflammatory and immune response to tuberculosis (TB) and also mediates the induction of the antimicrobial peptide cathelicidin. Deficiency of 25-hydroxyvitamin D and single nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR) gene may increase the risk of TB disease and decrease culture conversion rates in drug susceptible TB. Whether these VDR SNPs are found in African populations or impact multidrug-resistant (MDR) TB treatment has not been established...
2017: PloS One
https://www.readbyqxmd.com/read/28692301/high-dose-vitamin-d3-during-tuberculosis-treatment-in-mongolia-a-randomized-controlled-trial
#3
RANDOMIZED CONTROLLED TRIAL
Davaasambuu Ganmaa, Baatar Munkhzul, Wafaie Fawzi, Donna Spiegelman, Walter C Willett, Purev Bayasgalan, Erkhembayar Baasansuren, Burneebaatar Buyankhishig, Sereeter Oyun-Erdene, David A Jolliffe, Theodoros Xenakis, Sabri Bromage, Barry R Bloom, Adrian R Martineau
RATIONALE: Existing trials of adjunctive vitamin D in the treatment of pulmonary tuberculosis (PTB) are variously limited by small sample sizes, inadequate dosing regimens, and high baseline vitamin D status among participants. Comprehensive analyses of the effects of genetic variation in the vitamin D pathway on response to vitamin D supplementation are lacking. OBJECTIVES: To determine the effect of high-dose vitamin D3 on response to antimicrobial therapy for PTB and to evaluate the influence of single-nucleotide polymorphisms (SNPs) in vitamin D pathway genes on response to adjunctive vitamin D3...
September 1, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28583097/nramp1-and-vdr-gene-polymorphisms-in-susceptibility-to-pulmonary-tuberculosis-among-andhra-pradesh-population-in-india-a-case-control-study
#4
Rooth Vasantha Medapati, Sridevi Suvvari, Sudhakar Godi, Paddaiah Gangisetti
BACKGROUND: The aim of the present study was to evaluate the association of NRAMP1 -3'UTR, 274-CT,VDR- Fok1 VDR-Taq1 Polymorphisms with the risk of pulmonary tuberculosis. METHOD: A case -control study was conducted on Andhra Pradesh Population of India. Analysis of gene polymorphisms of NRAMP1 gene (3'UTR, 274CT) and VDR gene (Fok1 and Taq1) was done by using Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in Tuberculosis (TB) patients and healthy controls...
June 5, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28539299/-association-of-vitamin-d-receptor-gene-polymorphisms-with-susceptibility-to-bone-and-joint-tuberculosis-in-chinese-han-population
#5
Jia-Wei Zhang, Qiang Zhang, Dong-Bin Qu, Zhen Lin, Xue-Ming Ma, Xin Zhong, Chao-Hui Sang, Xu-Shi Chen, Zu-Kun Song, Piao Huang, Jian-Ming Jiang
OBJECTIVE: To investigate the association between vitamin D receptor (VDR) gene Apa I polymorphism and the susceptibility to bone and joint tuberculosis in Chinese Han population. METHODS: Between May, 2015 and June, 2016, 100 patients with bone and joint tuberculosis and 100 healthy volunteers were recruited concomitantly in Heyuan Hospital of Traditional Chinese Medicine. Vitamin D receptor gene Apa I polymorphisms in these subjects were analyzed using SNaPshot...
May 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28533426/a-reappraised-meta-analysis-of-the-genetic-association-between-vitamin-d-receptor-bsmi-rs1544410-polymorphism-and-pulmonary-tuberculosis-risk
#6
Mohammed Y Areeshi, Raju K Mandal, Sajad A Dar, Abdulrahman M Alshahrani, Aqeel Ahmad, Arshad Jawed, Mohd Wahid, Mohtashim Lohani, Aditya K Panda, Shafiul Haque
BsmI (rs1544410) polymorphism located in intron 8 at the 3'-end of the vitamin D receptor (VDR) gene is known to be involved in the regulation of mRNA stability. Many studies evaluated the possible correlation between VDR BsmI polymorphism and the risk of pulmonary tuberculosis (PTB), and reported conflicting results. In the present study, an updated meta-analysis was performed to evaluate the above-said association. PubMed, Embase, and Google Scholar web-databases were searched for the relevant studies and a meta-analysis was performed by calculating pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) for all the genetic models...
June 30, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28376475/osteopontin-bone-morphogenetic-protein-4-and-vitamin-d-receptor-gene-polymorphisms-in-the-susceptibility-and-clinical-severity-of-spinal-tuberculosis
#7
Guohua Wang, Liangyi Xie, Jianzhong Hu, Hongbin Lu, Xiangyang Liu, Yong Cao, Bin Liu, Yi Zhang, Xiongjie Shen
BACKGROUND/AIMS: Spinal tuberculosis (TB) is a common and dangerous form of extrapulmonary TB with unclear mechanisms in its occurrence and progression. This study investigated the clinical significances of bone morphogenetic protein-4 (BMP-4), osteopontin (OPN), and vitamin D receptor (VDR) gene polymorphism, mRNA and protein expression in spinal TB patients. METHODS: BMP-4 and OPN gene polymorphisms were detected by direct DNA sequencing, while VDR-FokI polymorphisms were analyzed using PCR-RFLP...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27785354/the-frequency-distribution-of-vitamin-d-receptor-fok-i-gene-polymorphism-among-ugandan-pulmonary-tb-patients
#8
Ester L Acen, William Worodria, Peter Mulamba, Andrew Kambugu, Joseph Erume
Background:Mycobacterium tuberculosis (TB) is still a major problem globally and especially in Africa. Vitamin D deficiency has been linked to TB in the past and studies have found vitamin D deficiency to be common among Ugandan TB patients. The functional activity of vitamin D is dependent on the genotype of the vitamin D receptor (VDR) polymorphic genes. Recent findings have indicated that VDR polymorphisms may cause increased resistance or susceptibility to TB. The vitamin D ligand and its receptor play a pivotal role in innate immunity by eliciting antimicrobial activity, which is important in prevention of TB...
2016: F1000Research
https://www.readbyqxmd.com/read/27695504/vitamin-d-receptor-gene-foki-polymorphisms-and-tuberculosis-susceptibility-a-meta-analysis
#9
REVIEW
Yan Cao, Xinjing Wang, Zhihong Cao, Xiaoxing Cheng
INTRODUCTION: The association between FokI polymorphism of vitamin D receptor (VDR) and tuberculosis (TB) susceptibility has been investigated previously; however, the results were inconsistent and conflicting. In the present study, a meta-analysis was performed to assess the relationship between VDR FokI gene polymorphism and the risk of TB. MATERIAL AND METHODS: Databases including PubMed and Embase were searched for genetic association studies of FokI polymorphism of vitamin D receptor (VDR) and TB...
October 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/27595605/vitamin-d-receptor-gene-associations-with-pulmonary-tuberculosis-in-a-tibetan-chinese-population
#10
Qunying Hu, Zhengshuai Chen, Guinian Liang, Fangping Mo, Hengxun Zhang, Shilin Xu, Yuhe Wang, Longli Kang, Tianbo Jin
BACKGROUND: The vitamin D receptor (VDR) mediates the immunological function of vitamin D3, which activates macrophages, and vitamin D deficiency has been linked to tuberculosis risk. Single nucleotide polymorphisms (SNPs) in VDR may influence the function of vitamin D and susceptibility to tuberculosis. METHODS: This study included 217 patients with pulmonary tuberculosis (PTB) and 383 healthy subjects in a Tibetan Chinese population living in and near Xi'an. Association analyses of SNPs in VDR were performed with the SPSS 17...
September 5, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27588937/vitamin-d-mediated-hypercalcemia-mechanisms-diagnosis-and-treatment
#11
REVIEW
Peter J Tebben, Ravinder J Singh, Rajiv Kumar
Hypercalcemia occurs in up to 4% of the population in association with malignancy, primary hyperparathyroidism, ingestion of excessive calcium and/or vitamin D, ectopic production of 1,25-dihydroxyvitamin D [1,25(OH)2D], and impaired degradation of 1,25(OH)2D. The ingestion of excessive amounts of vitamin D3 (or vitamin D2) results in hypercalcemia and hypercalciuria due to the formation of supraphysiological amounts of 25-hydroxyvitamin D [25(OH)D] that bind to the vitamin D receptor, albeit with lower affinity than the active form of the vitamin, 1,25(OH)2D, and the formation of 5,6-trans 25(OH)D, which binds to the vitamin D receptor more tightly than 25(OH)D...
October 2016: Endocrine Reviews
https://www.readbyqxmd.com/read/27207494/vitamin-d-status-vitamin-d-receptor-and-toll-like-receptor-2-polymorphisms-in-tuberculous-meningitis-a-case-control-study
#12
Imran Rizvi, Ravindra Kumar Garg, Amita Jain, Hardeep Singh Malhotra, Arvind Kumar Singh, Shantanu Prakash, Neeraj Kumar, Rajeev Garg, Rajesh Verma, Abbas Ali Mahdi, Praveen Kumar Sharma
INTRODUCTION: Vitamin D levels and genetic factors, vitamin D receptor (VDR) and Toll like receptor- 2 (TLR-2) gene single nucleotide polymorphisms (SNPs), determine susceptibility to pulmonary tuberculosis. We aimed to evaluate vitamin D deficiency, VDR and TLR-2 gene SNPs in tuberculous meningitis (TBM). METHODS: This case-control study included 130 subjects each in three arms (TBM, pulmonary tuberculosis and healthy control). This study was performed in a large tertiary care institution of North India...
October 2016: Infection
https://www.readbyqxmd.com/read/27160686/vitamin-d-deficiency-associates-with-susceptibility-to-tuberculosis-in-pakistan-but-polymorphisms-in-vdr-dbp-and-cyp2r1-do-not
#13
Kashaf Junaid, Abdul Rehman, David A Jolliffe, Tahir Saeed, Kristie Wood, Adrian R Martineau
BACKGROUND: Single nucleotide polymorphisms (SNPs) in the genes encoding the vitamin D receptor (VDR) and the vitamin D binding protein (DBP) have been reported to modify the influence of vitamin D deficiency on susceptibility to active tuberculosis (TB) in the UK, but this phenomenon has not been investigated in settings with a high TB burden. SNPs in CYP2R1, which encodes a vitamin D 25-hydroxylase enzyme, are known to influence vitamin D status, but their potential role in determining susceptibility to TB has not previously been investigated in any setting...
May 10, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27124026/25-hydroxy-vitamin-d-vitamin-d-receptor-and-toll-like-receptor-2-polymorphisms-in-spinal-tuberculosis-a-case-control-study
#14
Ajay Panwar, Ravindra Kumar Garg, Hardeep Singh Malhotra, Amita Jain, Arvind Kumar Singh, Shantanu Prakash, Neeraj Kumar, Rajiv Garg, Abbas Ali Mahdi, Rajesh Verma, Praveen Kumar Sharma
Vitamin D deficiency and vitamin D receptor (VDR) gene abnormalities confer susceptibility to tuberculosis. Toll-like receptors (TLRs), such asTLR-2, are also important mediators of inflammatory response against Mycobacterium tuberculosis. We evaluated serum vitamin D, and VDR and TLR-2 gene polymorphisms in patients with spinal tuberculosis.This study comprised of 3 groups: spinal tuberculosis, pulmonary tuberculosis, and controls (each with 106 subjects). Enzyme-linked immunosorbent assay was used to measure vitamin D levels, and polymerase chain reaction-sequencing method was used to analyze VDR and TLR-2 gene polymorphisms...
April 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27067904/regulatory-role-of-cdx-2-and-taq-i-polymorphism-of-vitamin-d-receptor-gene-on-chemokine-expression-in-pulmonary-tuberculosis
#15
M Harishankar, P Selvaraj
Vitamin D receptor (VDR) gene variants have been shown to be regulating the immune response in tuberculosis. We studied the regulatory role of VDR promoter Cdx-2 and 3'UTR TaqI gene variants on chemokine levels from culture filtrate antigen (CFA) stimulated with or without 1,25(OH)2D3 treated peripheral blood mononuclear cells of 50 pulmonary tuberculosis patients (PTB) and 51 normal healthy controls (HCs). In CFA with 1,25(OH)2D3 treated cultures, the MIP-1α, MIP-1β, RANTES levels were significantly decreased in Cdx-2 AA genotype compared to GG genotype, while a significantly increased MIG level was observed in Cdx-2 AA genotype (p<0...
June 2016: Human Immunology
https://www.readbyqxmd.com/read/26980499/canonical-pathways-networks-and-transcriptional-factor-regulation-by-clinical-strains-of-mycobacterium-tuberculosis-in-pulmonary-alveolar-epithelial-cells
#16
Nontobeko E Mvubu, Balakrishna Pillay, Junaid Gamieldien, William Bishai, Manormoney Pillay
Limited knowledge exists on pathways, networks and transcriptional factors regulated within epithelial cells by diverse Mycobacterium tuberculosis genotypes. This study aimed to elucidate these mechanisms induced in A549 epithelial cells by dominant clinical strains in KwaZulu-Natal, South Africa. RNA for sequencing was extracted from epithelial cells at 48 h post-infection with 5 strains at a multiplicity of infection of approximately 10:1. Bioinformatics analysis performed with the RNA-Seq Tuxedo pipeline identified differentially expressed genes...
March 2016: Tuberculosis
https://www.readbyqxmd.com/read/26872154/low-vitamin-d-levels-combined-with-pkp3-sigirr-tmem16j-host-variants-is-associated-with-tuberculosis-and-death-in-hiv-infected-and-exposed-infants
#17
Amita Gupta, Grace Montepiedra, Akshay Gupte, Bret Zeldow, Jennifer Jubulis, Barbara Detrick, Avy Violari, Shabir Madhi, Raziya Bobat, Mark Cotton, Charles Mitchell, Stephen Spector
BACKGROUND: This study examined the associations of 25-hydroxyvitamin D and specific host genetic variants that affect vitamin D levels or its effects on immune function, with the risk of TB or mortality in children. METHODS: A case-cohort sample of 466 South African infants enrolled in P1041 trial (NCT00080119) underwent 25-hydroxyvitamin D testing by chemiluminescent immunoassay. Single nucleotide polymorphisms (SNPs) that alter the effect of vitamin D [e.g. vitamin D receptor (VDR)], vitamin D levels [e...
2016: PloS One
https://www.readbyqxmd.com/read/26869016/vdr-and-vdbp-genes-polymorphisms-associated-with-susceptibility-to-tuberculosis-in-a-han-taiwanese-population
#18
Shih-Wei Lee, Tzu-Yi Chuang, Hsiu-Han Huang, Chi-Wei Liu, Yung-Hsi Kao, Lawrence Shih-Hsin Wu
BACKGROUND: The active metabolite (1, 25-dihydroxycholecalciferol) of vitamin D (25-hydroxycholecalciferol) leads to the activation of macrophages and the deficiency of vitamin D seems to be involved in the risk of tuberculosis (TB). The effects of vitamin D are exerted by interaction with the vitamin D receptor (VDR) and vitamin D receptor binding protein (VDBP) may be influenced by polymorphisms in the VDR and VDBP genes. In this study, variation in the VDR and VDBP genes was investigated in a Taiwanese population with TB...
October 2016: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/26774366/the-nramp1-vdr-tnf-%C3%AE-icam1-tlr2-and-tlr4-gene-polymorphisms-in-iranian-patients-with-pulmonary-tuberculosis-a-case-control-study
#19
Mohammad Jafari, Mohammad Reza Nasiri, Roozbeh Sanaei, Saber Anoosheh, Parisa Farnia, Adel Sepanjnia, Nader Tajik
The innate immune response drives early events in Mycobacterium tuberculosis infection. Since human genetic variation is an important determinant in the outcome of infection with M. tuberculosis, we typed polymorphisms in the innate immune molecules, such as natural-resistance-associated macrophage protein 1 (NRAMP1), Vitamin D receptor (VDR), Tumor necrosis factor alpha (TNF-α), intercellular adhesion molecule1 (ICAM-1), Toll-like receptor 2 (TLR2) and Toll-like receptor 4 (TLR4) in a case-control study of pulmonary tuberculosis in Iranian population...
April 2016: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/26729807/dietary-vitamin-d3-suppresses-pulmonary-immunopathology-associated-with-late-stage-tuberculosis-in-c3heb-fej-mice
#20
Allison E Reeme, Richard T Robinson
Tuberculosis (TB) is a significant human disease caused by inhalation of Mycobacterium tuberculosis. Left untreated, TB mortality is associated with a failure to resolve pulmonary immunopathology. There is currently widespread interest in using vitamin D3 (VitD3) as an adjunct therapy for TB because numerous in vitro studies have shown that VitD3 has direct and indirect mycobactericidal activities. However, to date, there have been no in vivo studies addressing whether VitD3 affects experimental TB outcome...
February 1, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
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