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https://www.readbyqxmd.com/read/28132411/a-case-report-of-disappearing-pigmented-skin-lesions-associated-with-pembrolizumab-treatment-for-metastatic-melanoma
#1
Z J Wolner, A A Marghoob, M P Pulitzer, M A Postow, M A Marchetti
Pembrolizumab is an immune checkpoint inhibitor that targets the programmed cell death (PD)-1 receptor. Common cutaneous adverse side effects of PD-1 inhibitors include maculopapular rash, pruritus, vitiligo, and lichenoid skin and mucosal reactions. Here, we describe a man in his sixties with metastatic melanoma treated with pembrolizumab who subsequently developed fading or disappearance of pigmented skin lesions, lightening of the skin, and poliosis of the eyebrows, eyelashes, and scalp and body hair. Compared to baseline high-resolution three-dimensional total body photography, we observed fading or disappearing of solar lentigines, seborrheic keratoses, and melanocytic naevi, suggesting that PD-1 inhibitors may affect the evolution of these benign skin lesions...
January 28, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28075031/angiotropic-syringomatous-carcinoma
#2
Eri Katayama, Hiroshi Saruta, Aya Nanri, Takekuni Nakama, Chika Ohata
Syringomatous carcinoma (SC) is a slow-growing malignant skin tumor that usually affects the face or scalp. An 83-year-old female developed SC on the sole, a rare location. Histopathologically, numerous ducts with few keratinizing cysts were seen in the upper dermis, and cords, strands, and nests with sclerotic stroma were seen in the deep dermis and subcutis. In addition to the perineural and intraneural invasion of the tumor, the tumor cells had also invaded the vessel walls. There was no intravasation of tumor cells or interruption of the endothelium...
January 11, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28045814/recalcitrant-invasive-skin-cancer-of-the-scalp-combined-extirpation-and-microsurgical-reconstruction-without-cranioplasty
#3
Gerald J Cho, Frederick Wang, Steven M Garcia, Jennifer Viner, William Y Hoffman, Michael W McDermott, Jason H Pomerantz
BACKGROUND: Recurrent invasive skin cancer of the scalp and calvarium is a difficult problem for which universally accepted treatment protocols have not been established. The authors present their 10-year experience with treatment of this specific subset of scalp reconstruction patients and present a successful treatment algorithm that is well suited to this patient population. METHODS: The authors retrospectively reviewed all patients of microsurgical scalp reconstruction performed from 2005 to 2015 that involved invasive cutaneous malignancies of the scalp and calvarium...
December 30, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28035664/primary-cutaneous-melanoma-of-the-scalp-patterns-of-recurrence
#4
David S Sparks, Tavis Read, Michael Lonne, Andrew P Barbour, Michael Wagels, Gerard J Bayley, B Mark Smithers
INTRODUCTION: Patients with primary melanoma of the scalp have been reported to have worse disease-related outcomes compared with other anatomical regions. There are few studies in the literature specifically addressing recurrence patterns and treatment outcomes for primary scalp melanoma as a discrete anatomical sub-region. We sought to identify key features adversely influencing disease control and survival and to clarify the role of resection plane, margin, and method of reconstruction in the management of this disease process...
December 30, 2016: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27878885/beware-when-the-hair-turns-dark-again-clinical-presentation-and-management-of-melanoma-in-situ-in-a-giant-congenital-naevus-on-the-scalp
#5
LETTER
D Crisan, K Scharffetter-Kochanek, R Dummer, N Treiber, A Sindrilaru, S Kastler, L A Schneider
No abstract text is available yet for this article.
November 23, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27870726/melanocytic-nevi-of-special-sites
#6
REVIEW
Christine S Ahn, Analia Guerra, Omar P Sangüeza
Melanocytic nevi located on specific regions of the body can demonstrate unusual histopathological features such as asymmetry, irregular nesting patterns, pagetoid spread, cytologic atypia, and rarely, mitotic activity. However, despite these features that may raise concern for malignant melanoma, these lesions follow a benign clinical course and do not require intervention. Also known as nevi of special sites or nevi with site-related atypia, these melanocytic nevi were initially described on acral sites and genitalia...
December 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27810611/management-of-skin-defect-following-resection-of-stage-iv-scalp-melanoma-a-case-report
#7
Yana Puckett, Eileen Bui, Sharmila Dissanaike
INTRODUCTION: Surgical defect left following excision of a large and neglected scalp melanoma of can pose a significant challenge for the surgeon. Scalp reconstruction encompasses options such as skin flaps, grafts, and various mechanical techniques. In scalp excision that involves dissection beyond the galea, skin grafts and flaps may not take well and not enough tissue may be available for a skin flap. PRESENTATION OF CASE: We present the case of a 64 year-old male with a giant scalp melanoma...
2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27792059/vitamin-d-receptor-immunohistochemistry-variability-in-sun-exposed-and-non-sun-exposed-melanomas
#8
Giovanni Paolino, Chiara Panetta, Carlo Cota, Dario Didona, Elisa Moliterni, Cinzia Di Mattia, Gaetano De Vita, Ugo Bottoni, Pietro Donati, Stefano Calvieri
Ultraviolet rays are one of the leading factors in the development of melanoma (MM); however, ultraviolet rays seem not to play a role in non-sun-exposed MM, where systemic immunosuppression, anatomical, and physiological features may contribute toward the development of the malignancy. Our aim was to evaluate vitamin D receptor (VDR) expression in shield-site melanoma (ST-MM) and non-shield-site melanoma (NST-MM) to find features that could explain the different biological behavior of MM according to the area of onset...
February 2017: Melanoma Research
https://www.readbyqxmd.com/read/27748080/variants-in-autophagy-related-genes-and-clinical-characteristics-in-melanoma-a-population-based-study
#9
Kirsten A M White, Li Luo, Todd A Thompson, Salina Torres, Chien-An Andy Hu, Nancy E Thomas, Jenna Lilyquist, Hoda Anton-Culver, Stephen B Gruber, Lynn From, Klaus J Busam, Irene Orlow, Peter A Kanetsky, Loraine D Marrett, Richard P Gallagher, Lidia Sacchetto, Stefano Rosso, Terence Dwyer, Anne E Cust, Colin B Begg, Marianne Berwick
Autophagy has been linked with melanoma risk and survival, but no polymorphisms in autophagy-related (ATG) genes have been investigated in relation to melanoma progression. We examined five single-nucleotide polymorphisms (SNPs) in three ATG genes (ATG5; ATG10; and ATG16L) with known or suspected impact on autophagic flux in an international population-based case-control study of melanoma. DNA from 911 melanoma patients was genotyped. An association was identified between (GG) (rs2241880) and earlier stage at diagnosis (OR 0...
November 2016: Cancer Medicine
https://www.readbyqxmd.com/read/27703647/the-prognostic-value-of-age-sex-and-subsite-in-cutaneous-head-and-neck-melanoma-a-clinical-review-of-recent-literature
#10
REVIEW
Sameep Kadakia, David Chan, Moustafa Mourad, Yadranko Ducic
CONTEXT: Cutaneous head and neck melanoma is a challenging disease owing to its aggressive nature and often times advanced stage at presentation. Age, sex, and subsite are three prognostic indicators which can be determined prior to treatment or testing, and can allow the practitioner to counsel the patient before initiating therapy. EVIDENCE ACQUISITION: A PubMed search was conducted utilizing various terms relating to the subject matter. Articles over the past 25 years were analyzed and appropriately selected for review...
June 2016: Iranian Journal of Cancer Prevention
https://www.readbyqxmd.com/read/27671185/parotid-cystic-lesion-in-amelanotic-malignant-melanoma
#11
Vitorino Modesto Dos Santos, Manoel da Costa Gondim Neto, Tereza Rodrigues de Carvalho Vieira de Melo, Iara Machado Motta
A 60-year Brazilian woman, presented with an enlarged lymph node in the neck for one year, and a superficial nonulcerated lesion was observed in the scalp. Fine needle aspiration and biopsy of the lymph node revealed amelanocytic metastasis, and immunohistochemistry study showed Melan-A/ Mart-1 antigen (clone A103 and S-100 protein). The entire suspected area of the scalp was further resected and an amelanotic melanoma without angiolymphatic invasion was diagnosed. Ultrasonography and PET-computed tomography showed hypermetabolic cystic area in the right parotid...
September 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/27607058/survival-and-surgical-outcomes-for-pediatric-head-and-neck-melanoma
#12
Morgan K Richards, Josephine Czechowicz, Adam B Goldin, Kenneth W Gow, John Doski, Melanie Goldfarb, Jed Nuchtern, Monica Langer, Elizabeth A Beierle, Sanjeev Vasudevan, Deepti Gupta, Sanjay R Parikh
Importance: Melanoma in children is rare, accounting for approximately 2% of all pediatric malignant neoplasms. However, for the past 30 years, the incidence of melanoma in those younger than 20 years has been increasing. Location of the primary tumor has been shown to be an important prognostic factor, with melanomas of the scalp and neck conferring a worse prognosis than those originating at other sites. Objective: To examine the survival, demographic, tumor, and treatment characteristics of pediatric head and neck melanoma...
January 1, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27579751/melanoma-associated-with-congenital-intermediate-common-blue-nevus-of-the-scalp-case-report
#13
Camila Sampaio Ribeiro, Sergio S Serpa, Maria Auxiliadora Jeunon Sousa, Thiago Jeunon
Melanomas can arise either de novo (70%) or from pre-existing melanocytic lesions (30%). Of the latter, most cases arise at the dermoepidermal junction from small congenital or acquired non-blue nevi while only a few arise from blue nevi, notably the cellular subtype and less commonly the common (dendritic) type. Melanomas that arise from blue nevi usually occur on the scalp with greater frequency, as in the case described. Although previous studies have discussed melanoma arising from giant congenital blue nevi, few have discussed those arising from intermediate blue nevi...
July 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/27573553/prepubertal-melanoma-arising-within-a-medium-sized-congenital-melanocytic-nevus
#14
Leah Lalor, Klaus Busam, Kara Shah
We report the case of an 8-year-old child who developed a 9.4-mm-deep melanoma within a medium-sized congenital melanocytic nevus on the scalp. Genetic analysis revealed an activating NRAS Q61R mutation within the melanoma, which is more commonly associated with large or giant congenital melanocytic nevi. This case demonstrates that even a "low-risk" congenital melanocytic nevus at a "low-risk" age must be monitored regularly for the development of malignancy.
November 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27573466/subcutaneous-melanocytoma-mimicking-a-lipoma-a-rare-presentation-of-a-rare-neoplasm-with-histological-immunohistochemical-cytogenetic-and-molecular-characterization
#15
Nitin Marwaha, Jacqueline R Batanian, Jeroen R Coppens, Matthew J Pierson, Jennifer Richards-Yutz, Jessica Ebrahimzadeh, Arupa Ganguly, Miguel A Guzman
Melanocytoma are the melanocytic tumors originating from leptomeningeal melanocytes. Melanocytomas are commonly seen in the central nervous system (CNS) and are often associated with neurocutaneous melanosis (NCM). However, simultaneous presentation of intra-axial and extracranial melanocytoma is a very rare event. Here, we report a unique case of 21-year-old male with intermediate-grade subcutaneous (SC) melanocytoma, mimicking lipoma, occurred synchronously with an intracranial melanocytoma, not associated with NCM...
December 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27550617/invasive-scalp-melanoma-role-for-enhanced-detection-through-professional-training
#16
Brendan P Lovasik, Ishna Sharma, Maria C Russell, Grant W Carlson, Keith A Delman, Monica Rizzo
BACKGROUND: Scalp and neck melanomas (SNMs) have a relatively poor prognosis compared to other sites, and represent an anatomically challenging area for detection. The aim of this study was to identify the role of the hairdresser in detection of SNMs. METHODS: A tertiary surgical oncology institutional database was retrospectively reviewed for all patients undergoing resection of a scalp, posterior neck, or retro auricular invasive primary melanoma between 2008 and 2014...
November 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27546291/cutaneous-head-and-neck-melanoma-chnm-a-population-based-study-of-the-prognostic-impact-of-tumor-location
#17
Per Helsing, Trude Eid Robsahm, Linda Vos, Syed Mohammad Husain Rizvi, Lars Andreas Akslen, Marit Bragelien Veierød
BACKGROUND: Most studies of cutaneous head and neck melanomas (CHNM) have reported poorer survival in CHNM compared with other sites, especially on the scalp/neck. OBJECTIVE: We sought to compare patient and tumor characteristics between CHNM and cutaneous trunk and extremity melanomas and between CHNM locations (face/ear vs scalp/neck, anterior vs posterior), and to study prognostic factors in patients with CHNM. METHODS: We studied all CHNM (n = 1074) from 8120 cases of cutaneous melanomas diagnosed in Norway in 2008 to 2012...
November 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27542665/male-pattern-baldness-and-risk-of-incident-skin-cancer-in-a-cohort-of-men
#18
Wen-Qing Li, Eunyoung Cho, Jiali Han, Martin A Weinstock, Abrar A Qureshi
We examined the association between male-pattern baldness and risk of incident skin cancer, including invasive melanoma, invasive squamous cell carcinoma (SCC), and basal cell carcinoma (BCC) in a prospective analysis, based on 36,032 participants from the Health Professionals' Follow-up Study. In 1992, participants reported their status of male-pattern baldness at age 45 years by choosing from five crown-view pictograms based on Norwood's classification. Diagnosis of skin cancers was reported biennially and information on melanoma and SCC was pathologically confirmed...
December 15, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27443622/-a-case-of-early-gastric-cancer-with-nodular-tumor-like-scalp-metastasis
#19
Young Wook Song, Woo Sub Kim, Gee Young Yun, Sun Wook Park, Sun Hyung Kang, Hee Seok Moon, Jae Kyu Sung, Hyun Yong Jeong
Many neoplasms, including lung cancer, breast cancer, melanoma, and gastrointestinal tract malignancy, possess potential for skin metastasis. Skin metastases can represent the first presentation of such malignancies and may be observed incidentally during routine exam. Skin metastases from gastric adenocarcinoma are uncommon, with a prevalence rate of 0.04-0.8%. Cutaneous metastases from gastric cancer are generally observed as the initial symptom of advanced gastric cancer. Early detection and treatment can increase patient survival...
July 25, 2016: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/27437239/basaloid-squamous-cell-carcinoma-of-scalp-from-a-pre-existing-cylindroma-metastasising-to-brain-a-rare-case-report
#20
Impana Bellavara Diwakar, Teerthanath Srinivas, Jayaram Shetty Kolakebail, Jayaprakash Shetty, Prachi Kukreja
Squamous cell carcinoma (SCC) is the second most common non-melanoma skin cancer and accounts for 90% of head and neck malignancies. Intracranial metastases of SCC are extremely rare. We are reporting a case of 55-year-old female with history of recurrent swelling over right side of forehead which was previously reported as cylindroma. CT scan of head revealed irregular lytic areas in right frontal bone suggestive of erosion. There were multiple small, rim enhancing lesions in bilateral parietal regions. Clinically it was diagnosed as malignant adnexal tumour...
May 2016: Journal of Clinical and Diagnostic Research: JCDR
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