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https://www.readbyqxmd.com/read/29136296/scalp-melanoma-after-anti-hair-loss-mesotherapy
#1
M Arenbergerova, P Arenberger, S Gkalpakiotis, R A Dahmen, E Sticova, A Fialova
Scalp melanoma comprises 3-5% of all cutaneous melanomas. The median age of the patients is 53 years and males are more frequently affected. The scalp melanomas tend to have nodular histology with a higher mitotic rate (>3/mm) and poorer prognosis (1). The risk factors for development of this tumor are still not defined but UV light and baldness may play a significant role (2-4). Mesotherapy is a non-surgical procedure currently being used to combat hair loss and promote hair growth. Usually a mixture of vitamins, minerals, growth factors, DHT blockers and/or stem cells extracts is injected into the dermal layer of skin (5,6)...
November 14, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29122555/diffuse-recurrent-cutaneous-melanoma-of-the-scalp-and-neck-successfully-treated-with-volumetric-modulated-arc-therapy-and-concurrent-ipilimumab
#2
Ryan K Schmid, Amy Harker-Murray, Karen Niemczyk, Jared R Robbins
No abstract text is available yet for this article.
September 19, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29112483/clinicopathologic-factors-predictive-of-occult-lymph-node-involvement-in-cutaneous-head-and-neck-melanoma
#3
Pratyusha Yalamanchi, Jason A Brant, Jinbo Chen, Jason G Newman
Objectives Evaluate clinicopathologic factors contributing to regional lymph node (LN) metastases in cutaneous head and neck melanoma (HNM). Study Design Retrospective review of a national cancer database. Setting National Cancer Database (2004-2012). Methods National Cancer Database (NCDB) cases diagnosed between 2004 and 2012 were reviewed. Inclusion criteria were head and neck cutaneous site codes, melanoma histology codes, and clinically node-negative status. Independent, clinicopathologic factors associated with pathologic positive LN status were identified by multivariable logistic regression...
November 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29104720/dasatinib-induced-seborrheic-dermatitis-like-eruption
#4
Ryan R Riahi, Philip R Cohen
Dasatinib is an oral tyrosine kinase inhibitor approved for imatinib-resistant chronic myelogenous leukemia. It has been investigated in treating other neoplasms, including non-small-cell lung cancer and a subset of melanomas. Seborrheic dermatitis is characterized by erythematous patches or plaques with scaling typically affecting the external ear, glabella, hair-bearing areas of the face, nasolabial fold, and scalp. Antitumor agents are often associated with mucocutaneous side effects, including seborrheic dermatitis...
July 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29036257/improvement-of-actinic-keratoses-using-topical-dna-repair-enzymes-a-randomized-placebo-controlled-trial
#5
Marie Stoddard, Jennifer Herrmann, Lauren Moy, Ronald Moy
BACKGROUND: Actinic keratoses (AKs) are proliferations of abnormal keratinocytes, which may progress into non-melanoma skin cancers. Although multiple treatment modalities exist for AKs, their incidence continues to rise, making new methods of both prevention and treatment necessary. DNA repair enzymes have been shown to reverse sun-damage, resulting in reduced rates of AKs and non-melanoma skin cancer (NMSC) in specific patient populations. OBJECTIVE: We investigated the efficacy of a topical DNA repair enzyme lotion as a field therapy for AKs...
October 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29034495/melanoma-arising-from-a-plaque-type-blue-naevus-with-subcutaneous-cellular-nodules-of-the-scalp
#6
L Yan, L Tognetti, N Nami, A Lamberti, C Miracco, L Sun, M Fimiani, P Rubegni
Plaque-type blue naevus (PTBN) is a very rare variant of blue naevus (BN). The potential malignancy of subcutaneous cellular nodules (SCN) in PTBN was discovered in 2012, and there is currently no clear consensus on prognostic factors or management guidelines of such lesions. PTBN on the scalp have not been described in the literature. We report the clinical, histopathological and immunohistological features of a 50-year-old man who presented with a 30-year history of scalp PTBN, with malignant proliferation of nodular elements and fatal outcome 8 years later...
October 15, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29033813/recurrence-of-melanoma-after-starting-apremilast-for-psoriasis
#7
Thomas G Salopek
This is a report on a 32-year-old man with a history of two previous melanomas with concurrent plaque-type psoriasis. His history dates to 2009, when he was diagnosed with his first melanoma on the right occiput, Clark's level IV, tumor thickness 1.53 mm, nonulcerated, mitotic index 1/mm(2). He subsequently developed nodal recurrence after an initial negative sentinel lymph node biopsy and was treated with complete lymph node dissection. In 2012, he was diagnosed with a second primary melanoma on the right upper chest, Clark's level IV, tumor thickness 0...
May 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/28988442/dramatic-response-to-nivolumab-in-xeroderma-pigmentosum-skin-tumor
#8
Fanny Chambon, Sophie Osdoit, Kelly Bagny, Anne Moro, Jacqueline Nguyen, Yves Réguerre
We report the case of a 6-year-old female with xeroderma pigmentosum (XP) who developed a nonoperable scalp tumor, treated with anti-programmed cell death protein 1 (anti-PD-1) therapy (nivolumab). She presented with a sarcomatoid carcinoma of the scalp with bone lysis as well as vascular and meningeal contact. Nivolumab was initiated because it has emerged as a promising immunotherapy. We observed a dramatic tumor response with excellent tolerance. However, while on nivolumab therapy she developed two large skin melanomas and several squamous cell carcinomas, which have been resected...
October 8, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28809777/pigmented-epithelioid-melanocytoma-pem-animal-type-melanoma-atm-quest-for-an-origin-report-of-one-unusual-case-indicating-follicular-origin-and-another-arising-in-an-intradermal-nevus
#9
Ashley Tarasen, J Andrew Carlson, M Kathryn Leonard, Glenn Merlino, David Kaetzel, Andrzej T Slominski
Pigmented epithelioid melanocytoma (PEM) is a tumor encompassing epithelioid blue nevus of Carney complex (EBN of CNC) and was previously termed animal-type melanoma. Histologically PEMs are heavily pigmented spindled and epithelioid dermal melanocytic tumors with infiltrative borders, however, their origin remains unclear. Stem cells for the epidermis and hair follicle are located in the bulge area of the hair follicle with the potential to differentiate into multiple lineages. Multiple cutaneous carcinomas, including follicular cutaneous squamous cell carcinoma (FSCC), are thought to arise from stem cells in the follicular bulge...
August 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28802002/congenital-neurocristic-cutaneous-hamartoma-with-poliosis-a-case-report
#10
Lauren M Wilson, Knox J Beasley, Timothy C Sorrells, Viviana V Johnson
Neurocristic cutaneous hamartomas (NCH) are rare, pigmented skin lesions derived from the abnormal migration of neural crest cells. We report the case of a 57-year-old female with a congenital localized area of poliosis and underlying pigmented patch on her scalp. Analysis of 2 punch biopsies yielded features consistent with NCH. Histopathology revealed schwannian-differentiated spindle cells and melanocytic components in the dermis. The spindle cells stained positively for S-100 and the stroma showed a prominent CD34 staining...
November 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28800031/risk-factors-for-development-of-melanoma-brain-metastasis-and-disease-progression-a-single-center-retrospective-analysis
#11
Laura J Gardner, Morgan Ward, Robert H I Andtbacka, Kenneth M Boucher, Glen M Bowen, Tawnya L Bowles, Adam L Cohen, Kenneth Grossmann, Ying J Hitchcock, Sheri L Holmen, John Hyngstrom, Hung Khong, Martin McMahon, Marcus M Monroe, Carolyn B Ross, Gita Suneja, David Wada, Douglas Grossman
Melanoma metastasis to the brain is associated with a poor prognosis. We sought to determine patient demographics and primary tumor factors associated with the development of brain metastasis (BM) and survival. We also investigated whether the BM detection setting (routine screening vs. symptomatic presentation) affected clinical outcomes. A database of melanoma patients seen from 1999 to 2015 at our institution was reviewed to identify patients who developed BM. Patients with BM were matched by initial stage with patients who did not develop BM as a control group...
October 2017: Melanoma Research
https://www.readbyqxmd.com/read/28794873/congenital-and-infantile-malignant-melanoma-of-the-scalp-a-systematic-review
#12
REVIEW
Sohaib Tariq, Hussain Shallwani, Muhammad Waqas, Muhammad Ehsan Bari
Congenital and infantile malignant melanomas are rare and typically carry poor prognosis. The purpose of this article was to review the data on congenital and infantile malignant melanomas of the scalp in order to understand its presentation, diagnosis, management, and outcomes of congenital melanoma of scalp. We searched PubMed, CINAHL and Cochrane databases. Ten cases of congenital and 3 cases of infantile malignant melanoma of scalp were identified. The diagnosis was confirmed by biopsy and histological analysis for confirmation...
September 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28752561/preliminary-evaluation-of-reflectance-confocal-microscopy-features-of-scalp-melanoma
#13
Elisa Benati, Caterina Longo, Simonetta Piana, Elvira Moscarella
No abstract text is available yet for this article.
July 28, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28751990/dermal-substitutes-use-in-reconstructive-surgery-for-skin-tumors-a-single-center-experience
#14
Mariane Campagnari, Andrea S Jafelicci, Helio A Carneiro, Eduard R Brechtbühl, Eduardo Bertolli, João P Duprat Neto
Reconstructive surgery following skin tumor resection can be challenging. Treatment options after removing the tumor are skin grafting, local pedicled and axial flaps, or microsurgery for complex and extensive wounds correction. Recently, the use of dermal substitutes has been extended to reconstructive surgery in cutaneous oncology. Objectives. To report both a single-center experience using dermal substitutes in reconstructive surgery for skin malignancies and reconstructive surgery's outcomes. Methods and Results...
2017: International Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28748684/prognostic-factors-in-head-and-neck-melanoma-according-to-facial-aesthetic-units
#15
Giovanni Paolino, Michele Cardone, Dario Didona, Elisa Moliterni, Luigi Losco, Paola Corsetti, Giusy Schipani, Teresa Lopez, Stefano Calvieri, Ugo Bottoni
BACKGROUND: Head and neck melanoma is a clinical challenge. Indeed, cutaneous head and neck melanoma shows a worse prognosis in comparison to melanomas of other body sites. Although the emphasis on facial cosmetic preservation plays a pivotal role in comparison to other body areas, specific facial aesthetic units could also play a key role in the prognostic evaluation of the malignancy. METHODS: The aim of the current study was to evaluate the general outcome and clinicopathological features of head and neck melanoma and to detect prognostic differences according to each facial aesthetic unit...
July 26, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28675691/pd-1-inhibition-in-congenital-pigment-synthesizing-metastatic-melanoma
#16
Angela C Weyand, Rajen J Mody, Raja M Rabah, Valerie P Opipari
A newborn female child was born with a congenital pigment synthesizing melanoma of the scalp. Further workup revealed metastatic disease within the liver, lungs, and left tibia. Whole exome sequencing was performed on multiple samples that revealed one somatic mutation, lysine methyltransferase 2C (KMT2C), at low allelic frequency but no v-Raf murine sarcoma viral oncogene homolog B (BRAF), NF-1 mutation. Programmed death ligand 1 was moderately expressed. Treatment was initiated with the programmed cell death protein 1 inhibitor nivolumab...
July 4, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28670070/two-cancers-in-one-breast-carcinoma-with-underlying-melanoma
#17
Nicholas A Douville, Elizabeth A Sakach, Elizabeth A Wiewiorowski, William Herlihy, John E Pippen
A 61-year-old woman presented with a diagnosis of metastatic invasive lobular carcinoma of the right breast, and after treatment it had regressed or was stable except for a scalp nodule. When biopsied, the outer edges of the scalp lesion had findings consistent with breast carcinoma; however, the bulk of the tumor's pathology was consistent with melanoma. It appeared that most of the tumor was a highly vascularized melanoma with lobular breast carcinoma noted at its edges.
July 2017: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/28635084/primary-tumor-sites-in-relation-to-ultraviolet-radiation-exposure-and-skin-visibility-correlate-with-survival-in-cutaneous-melanoma
#18
Daniela Gordon, Johan Hansson, Sandra Eloranta, Max Gordon, Peter Gillgren, Karin E Smedby
The prognostic value of detailed anatomic site and ultraviolet radiation (UVR) exposure patterns has not been fully determined in cutaneous melanoma. Thus, we reviewed medical records for detailed site in a population-based retrospective Swedish patient cohort diagnosed with primary invasive melanoma 1976-2003 (n = 5,973). We followed the patients from date of diagnosis until death, emigration or December 31(st) 2013, and evaluated melanoma-specific survival by subsite in a multivariable regression model adjusting for established prognostic factors...
October 1, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28602049/baldness-and-scalp-melanoma
#19
E Benati, C Longo, C Bombonato, E Moscarella, R Alfano, G Argenziano
Nearly 20% of melanomas occur on the head and neck area(1) but only 2-5% arise on the scalp.(2) Several studies reported a worse prognosis of scalp melanoma compared to other body sites, being unclear the reason for this phenomenon.(3) Melanoma and non-melanoma skin cancer of the scalp are most frequent in bald men older than 65 years. This article is protected by copyright. All rights reserved.
June 11, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28543136/the-prognostic-importance-of-scalp-location-in-primary-head-and-neck-melanoma
#20
Junko Ozao-Choy, Daniel W Nelson, Jason Hiles, Stacey Stern, Jeong Lim Yoon, Myung Shin Sim, Mark B Faries
BACKGROUND AND OBJECTIVES: For patients with cutaneous melanoma, primary tumors located in the head and neck is associated with poor outcomes. The reason for this difference and whether it is applicable to all locations within the head and neck remains unclear. We hypothesized that scalp melanoma is uniquely distinguished from other anatomic sites and is independently responsible for the poor prognosis of head and neck melanoma. METHODS: Query and analysis of a prospectively maintained melanoma database of all patients treated for primary cutaneous melanoma from 1971 to 2010...
September 2017: Journal of Surgical Oncology
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